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215 results on '"Lee, Ing-Kit"'

10. Relationship between the Number of Repeats in the Neck Regions of L-SIGN and Augmented Virus Replication and Immune Responses in Dengue Hemorrhagic Fever.

Author

Liu, Keh-Sen, Chen, Po-Ming, Wang, Lin, Lee, Ing-Kit, Yang, Kuender D., and Chen, Rong-Fu

Subjects
DENGUE hemorrhagic fever, DENGUE, DENGUE viruses, IMMUNE response, VIRAL replication, VIRUS diseases, TANDEM repeats
Abstract

C-type lectins play a crucial role as pathogen-recognition receptors for the dengue virus, which is responsible for causing both dengue fever (DF) and dengue hemorrhagic fever (DHF). DHF is a serious illness caused by the dengue virus, which exists in four different serotypes: DEN-1, DEN-2, DEN-3, and DEN-4. We conducted a genetic association study, during a significant DEN-2 outbreak in southern Taiwan, to explore how variations in the neck-region length of L-SIGN (also known as CD209L, CD299, or CLEC4M) impact the severity of dengue infection. PCR genotyping was utilized to identify polymorphisms in variable-number tandem repeats. We constructed L-SIGN variants containing either 7- or 9-tandem repeats and transfected these constructs into K562 and U937 cells, and cytokine and chemokine levels were evaluated using enzyme-linked immunosorbent assays (ELISAs) following DEN-2 virus infection. The L-SIGN allele 9 was observed to correlate with a heightened risk of developing DHF. Subsequent results revealed that the 9-tandem repeat was linked to elevated viral load alongside predominant T-helper 2 (Th2) cell responses (IL-4 and IL-10) in K562 and U937 cells. Transfecting K562 cells in vitro with L-SIGN variants containing 7- and 9-tandem repeats confirmed that the 9-tandem repeat transfectants facilitated a higher dengue viral load accompanied by increased cytokine production (MCP-1, IL-6, and IL-8). Considering the higher prevalence of DHF and an increased frequency of the L-SIGN neck's 9-tandem repeat in the Taiwanese population, individuals with the 9-tandem repeat may necessitate more stringent protection against mosquito bites during dengue outbreaks in Taiwan. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Prognostic factors for critically ill surgical patients with unplanned intensive care unit readmission: Developing a novel predictive scoring model for predicting readmission

Author

Lin, Ting-Lung, primary, Chen, I-Ling, additional, Lai, Wei-Hung, additional, Chen, Ying-Ju, additional, Chang, Po-Hsun, additional, Wu, Kuan-Han, additional, Wang, Yu-Chen, additional, Li, Wei-Feng, additional, Liu, Yueh-Wei, additional, Wang, Chih-Chi, additional, and Lee, Ing-Kit, additional

Published
2023
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13. Risk factors for pre‐transplantation bacteremia in adults with end‐stage liver disease: Effects on outcomes of liver transplantation

Author

Lee, Ing‐Kit, primary, Chang, Po‐Hsun, additional, Li, Wei‐Feng, additional, Yeh, Cheng‐His, additional, Yin, Shih‐Min, additional, Lin, Yu‐Cheng, additional, Tzeng, Wei‐Juo, additional, Liu, Yu‐Ling, additional, Wang, Chih‐Chi, additional, Chen, Chao‐Long, additional, Lin, Chih‐Che, additional, and Chen, Yi‐Chun, additional

Published
2023
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14. Perception and Mental Health Status Regarding COVID-19 Vaccination Among Taiwanese Adolescents and Their Caregivers

Author

Hwang, Jade Winjei, primary, Chien, Shao Ju, additional, Wang, Chih-Chi, additional, Kuo, Kuang-Che, additional, Tang, Kuo-Shu, additional, Lee, Yu, additional, Chen, Yi-Chun, additional, Lo, Mao-Hung, additional, Lee, Ing-Kit, additional, Chuah, Seng-Kee, additional, Lee, Chien-Te, additional, Kung, Chia-Te, additional, and Wang, Liang-Jen, additional

Published
2023
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17. Risk factors for pre‐transplantation bacteremia in adults with end‐stage liver disease: Effects on outcomes of liver transplantation.

Author

Lee, Ing‐Kit, Chang, Po‐Hsun, Li, Wei‐Feng, Yeh, Cheng‐His, Yin, Shih‐Min, Lin, Yu‐Cheng, Tzeng, Wei‐Juo, Liu, Yu‐Ling, Wang, Chih‐Chi, Chen, Chao‐Long, Lin, Chih‐Che, and Chen, Yi‐Chun

Subjects
*BACTEREMIA, *LIVER transplantation, *LIVER diseases, *TREATMENT effectiveness, *URINARY tract infections, *INTERNATIONAL normalized ratio
Abstract

Background and aim: Limited data are available regarding pre‐liver transplantation (LT) bacteremia in adults with end‐stage liver disease. In this study, we investigated the risk factors independently associated with pre‐LT bacteremia and their effects on clinical outcomes of LT. Methods: This retrospective study performed between 2010 and 2021 included 1287 LT recipients. The study population was categorized into patients with pre‐LT bacteremia and those without pre‐LT infection. Pre‐LT bacteremia was defined as bacteremia detected within 90 days before LT. Results: Among 1287 LT recipients, 92 (7.1%) developed pre‐LT bacteremia. The mean interval between bacteremia and LT was 28.3 ± 19.5 days. Of these 92 patients, seven (7.6%) patients died after LT. Of the 99 microorganisms isolated in this study, gram‐negative bacteria were the most common microbes (72.7%). Bacteremia was mainly attributed to spontaneous bacterial peritonitis. The most common pathogen isolated was Escherichia coli (25.2%), followed by Klebsiella pneumoniae (18.2%), and Staphylococcus aureus (15.1%). Multivariate analysis showed that massive ascites (adjusted odds ratio [OR] 1.67, 95% confidence Interval [CI] 1.048–2.687) and a prolonged international normalized ratio for prothrombin time (adjusted OR 1.13, 95% CI 1.074–1.257) were independent risk factors for pre‐LT bacteremia in patients with end‐stage liver disease. Intensive care unit and in‐hospital stay were significantly longer, and in‐hospital mortality was significantly higher among LT recipients with pre‐LT bacteremia than among those without pre‐LT infection. Conclusions: This study highlights predictors of pre‐LT bacteremia in patients with end‐stage liver disease. Pre‐LT bacteremia increases the post‐transplantation mortality risk. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Parental Attitudes, Intentions, Decisions, and Psychological Wellbeing Regarding COVID-19 Vaccination: Preschool, School-Age, and Adolescent Caregivers

Author

Wang, Liang-Jen, primary, Kou, Kuang-Che, additional, Tang, Kuo-Shu, additional, Lee, Yu, additional, Chen, Yi-Chun, additional, Lo, Mao-Hung, additional, Lee, Ing-Kit, additional, Chuah, Seng-Kee, additional, Lee, Chien-Te, additional, Kung, Chia-Te, additional, Wang, Chih-Chi, additional, and Chien, Shao-Ju, additional

Published
2022
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24. Psychological Reactions of Hospital Workers to a Pandemic: A Comparison of SARS-CoV-2 in 2020 and SARS in 2003

Author

Lee, Yu, primary, Wang, Liang-Jen, additional, Chou, Wen-Jiun, additional, Chiang, Ming-Chu, additional, Huang, Shan, additional, Lin, Yi-Chun, additional, Lin, Jie-Yi, additional, Chiu, Nien-Mu, additional, Chen, Chih-Hung, additional, Lee, Ing-Kit, additional, Kung, Chia-Te, additional, Wang, Chih-Chi, additional, and Chong, Mian-Yoon, additional

Published
2022
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27. Correlation of pandemic (H1N1) 2009 viral load with disease severity and prolonged viral shedding in children

Author

Li, Chung-Chen, Wang, Lin, Eng, Hock-Liew, You, Huey-Ling, Chang, Ling-Sai, Tang, Kuo- Shu, Lin, Ying-Jui, Kuo, Hsuan-Chang, Lee, Ing-Kit, Liu, Jien-Wei, Huang, Eng-Yen, and Yang, Kuender D.

Subjects
Swine influenza -- Diagnosis -- Care and treatment -- Research -- Usage -- Health aspects, Viremia -- Measurement, Health
Abstract

The influenza A pandemic (H1N1) 2009 virus, initially identified in Mexico and the United States in April 2009, has been reported in >213 countries (1). Severe illness and death can [...]

Published
2010
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34. Demographic differences in people living with HIV according to recruitment sources: comparison between health-care systems and social media networks

Author

Hsiao, Yu-Hsiang, primary, Lee, Ing-Kit, additional, Lin, Te-Yu, additional, Liao, Chia-Hung, additional, Lee, Chen-Hsiang, additional, Ku, Wen-Wei, additional, Huang, Shie-Shian, additional, Yu, Chia-Hui, additional, Liu, Zhuo-Hao, additional, Chiu, Yi-Chi, additional, Lin, Yi-Hui, additional, and Chen, Nan-Yu, additional

Published
2019
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36. Diabetic patients suffering dengue are at risk for development of dengue shock syndrome/severe dengue: Emphasizing the impacts of co-existing comorbidity(ies) and glycemic control on dengue severity

Author

Lee, Ing-Kit, Hsieh, Ching-Jung, Lee, Chien-Te, and Liu, Jien-Wei

Abstract

The impact of type 2 diabetes mellitus (DM2) on clinical severity of dengue has not been fully understood. We aimed to assess risk factors for dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS) and severe dengue (SD) (defined based on the World Health Organization 1997 and 2009 dengue classifications), and additionally identify, among DM2 patients, who are at risk for developing DHF/DSS and severe dengue.

Published
2024
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37. Analyses of clinical and laboratory characteristics of dengue adults at their hospital presentations based on the World Health Organization clinical-phase framework: Emphasizing risk of severe dengue in the elderly

Author

Kuo, Hong-Jie, Lee, Ing-Kit, and Liu, Jien-Wei

Abstract

Dengue clinically dynamically changes over time; the World Health Organization (WHO) dengue classification framework proposed 3 dengue clinical phases—febrile (days 1–3), critical (days 4–6) and recovery (days ≥7) phases. This study aimed to better understand clinical and laboratory characteristics in adults (≥18 years) suffering dengue in different clinical phases at their hospital presentations.

Published
2024
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38. Demographic differences in people living with HIV according to recruitment sources: comparison between health-care systems and social media networks.

Author

Hsiao, Yu-Hsiang, Lee, Ing-Kit, Lin, Te-Yu, Liao, Chia-Hung, Lee, Chen-Hsiang, Ku, Wen-Wei, Huang, Shie-Shian, Yu, Chia-Hui, Liu, Zhuo-Hao, Chiu, Yi-Chi, Lin, Yi-Hui, and Chen, Nan-Yu

Subjects
*AGE distribution, *CENSUS, *DISABILITY evaluation, *DISCRIMINATION (Sociology), *HEALTH facilities, *HIV infections, *HIV-positive persons, *QUESTIONNAIRES, *HUMAN sexuality, *SOCIAL stigma, *SURVEYS, *SOCIOECONOMIC factors, *EDUCATIONAL attainment, *SOCIAL media, *DISEASE prevalence, *HUMAN research subjects, *CROSS-sectional method, *PATIENT selection, *HEALTH literacy, *DISEASE duration
Abstract

With the improvement of internet technology in health applications, the utilization of internet and social media as new survey methodologies and recruitment source for research participants have been encouraged, yet evidence of the feasibility in people living with HIV (PLHIV) study is still lacking. We conducted a cross-sectional survey to determine whether there are differences among PLHIV recruited from social media networks and health-care systems using an HIV stigma and discrimination questionnaire. The result revealed that PLHIV recruited from social media networks were younger, more sexually active, and had higher educational status and awareness of the country's HIV rights protection laws than those recruited from hospitals. By contrast, participants recruited from hospitals were more diverse regarding key population compositions, had lived with HIV for a longer duration, had a higher prevalence of concomitant physical disabilities than those recruited from social media networks, and fit Taiwan PLHIV characteristics described by 2016 census from Taiwan Centres for Disease Control. We conclude that sampling bias exists when utilizing social media networks for PLHIV studies. [ABSTRACT FROM AUTHOR]

Published
2020
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41. Differences in Mortality and Clinical Manifestations of Dengue Hemorrhagic Fever in Taiwan in Different Years: A Comparison for Cases in 2014 and 2015 Epidemics

Author

Chang, Ko, primary, Lee, Ing-Kit, additional, Chin, Yi-Ying, additional, Lu, Po-Liang, additional, Huang, Chun-Chi, additional, Hung, Chih-Hsing, additional, Huang, Chung-Hao, additional, Wu, Meng-Chieh, additional, Lai, Ping-Chang, additional, Lin, Chun-Yu, additional, Wu, Deng-Chyang, additional, Hsieh, Hsiao-Cheng, additional, Chen, Tun-Chieh, additional, Chen, Yen-Hsu, additional, and Yu, Hsin-Liang, additional

Published
2017
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42. Is asthma a protective factor for dengue fever? In vitroexperiment and nationwide population-based cohort analysis

Author

Yu, Hong-Ren, Tsai, Jui-Hsiu, Richard Lin, Chun-Hung, Wang, Jiu-Yao, Wen, Yen-Hsia, Wu, Shihn-Sheng, Hou, Yuan, Lee, Ing-Kit, Tu, Hung-Pin, and Lee, Yi-Chen

Abstract

Dengue fever (DF) is the most rapidly spreading mosquito-borne viral disease. Practical vaccines or specific therapeutics are still expected. Environmental factors and genetic factors affect the susceptibility of Dengue virus (DV) infection. Asthma is a common allergic disease, with house dust mites (HDMs) being the most important allergens. Asthmatic patients are susceptible to several microorganism infections.

Published
2019
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