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Molecular chirality is represented as broken mirror symmetry in the structural orientation of constituent atoms and plays a pivotal role at every scale of nature. Since the discovery of the chiroptic property of chiral molecules, the characterization of molecular chirality is important in the fields of biology, physics, and chemistry. Over the centuries, the field of optical chiral sensing was based on chiral light–matter interactions between chiral molecules and polarized light. Starting from simple optics-based sensing, the utilization of plasmonic materials that could control local chiral light–matter interactions by squeezing light into molecules successfully facilitated chiral sensing into noninvasive, ultrasensitive, and accurate detection. In this Review, the importance of plasmonic materials and their engineering in chiral sensing are discussed based on the principle of chiral light–matter interactions and the theory of optical chirality and chiral perturbation; thus, this Review can serve as a milestone for the proper design and utilization of plasmonic nanostructures for improved chiral sensing. [ABSTRACT FROM AUTHOR]

To develop functional varieties of Capsicum spp. leaves, 40 genetic resources were collected and extracted with 30% aqueous-fermented ethanol. We investigated the protective effects of extracts from 40 genetic resources of Capsicum spp. on glutamate-induced HT22 and LPS-induced BV2 cells. The results showed that the five extracts exhibited cell-protective activities. We also investigated the anti-inflammatory effects of these five extracts on LPS-induced BV2 cell neuroinflammation and found that 23OM18 exhibited superior anti-inflammatory effects. We further investigated the protective activity and anti-inflammatory mechanisms of 23OM18 in these two cell models. In addition, the profiles of 16 metabolites were compared between the representative accessions and among the five genetic resources using ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS). The results showed that 23OM18 protected HT22 cells by inhibiting reactive oxygen species generation and regulating the MAPK-JNK signaling pathway, thereby reducing LPS-induced BV2 cell neuroinflammation by regulating the NF-κB and MAPK signaling pathways. Based on these results, 23OM18 has the potential to be developed as a functional food for the treatment of neurodegenerative diseases. [ABSTRACT FROM AUTHOR]

Watermelon (Citrullus spp.) is an economically important crop globally, but it is susceptible to various diseases, including powdery mildew. Previous studies have identified genetic factors associated with powdery mildew resistance. However, further research using diverse genetic approaches is necessary to elucidate the underlying genetic mechanisms of this resistance. In this study, the germplasm collection comprising highly homozygous inbred lines was employed, which enabled the accumulation of consistent data and improved the reliability of the genome-wide association study (GWAS) findings. Our investigation identified two significant single-nucleotide polymorphisms (SNPs), pm2.1 and pm3.1, which were strongly associated with disease resistance. Moreover, several candidate genes were revealed within the linkage disequilibrium (LD) blocks surrounding the significant SNPs. In conclusion, the identification of significant SNPs and their additive effects, combined with the discovery of relevant candidate genes, expanded our understanding of the genetic basis of disease resistance and can pave the way for the development of more resilient watermelon cultivars through marker-assisted selection. [ABSTRACT FROM AUTHOR]

AbstractWhile South Koreans tend to quickly adopt new technologies, such as mobile apps, without facing technological difficulties, this population uses dating apps at a relatively low rate compared with Western countries. The current study employes the Theory of Planned Behavior (TPB) to examine psychological factors, as opposed to technological factors, to explain why South Koreans—particularly female young adults—rarely use dating apps to find potential romantic partners. Participants were 309 women who completed an online survey assessing their attitudes toward dating apps, subjective norms regarding dating apps, and perceived risks. As for behavioral control, factors of the original TPB were collected, and the relationships among these factors were analyzed. The results indicated that the initially suggested model did not show an acceptable fit of the data. Among the three factors, attitude towards dating apps was the most important in predicting intention, while actual usage of the apps negatively affected future intentions. Implications and future research directions are discussed. [ABSTRACT FROM AUTHOR]

Understanding chirality, or handedness, in molecules is important because of the enantioselectivity that is observed in many biochemical reactions.sup.1, and because of the recent development of chiral metamaterials with exceptional light-manipulating capabilities, such as polarization control.sup.2-4, a negative refractive index.sup.5 and chiral sensing.sup.6. Chiral nanostructures have been produced using nanofabrication techniques such as lithography.sup.7 and molecular self-assembly.sup.8-11, but large-scale and simple fabrication methods for three-dimensional chiral structures remain a challenge. In this regard, chirality transfer represents a simpler and more efficient method for controlling chiral morphology.sup.12-18. Although a few studies.sup.18,19 have described the transfer of molecular chirality into micrometre-sized helical ceramic crystals, this technique has yet to be implemented for metal nanoparticles with sizes of hundreds of nanometres. Here we develop a strategy for synthesizing chiral gold nanoparticles that involves using amino acids and peptides to control the optical activity, handedness and chiral plasmonic resonance of the nanoparticles. The key requirement for achieving such chiral structures is the formation of high-Miller-index surfaces ({hkl}, h [not equal to] k [not equal to] l [not equal to] 0) that are intrinsically chiral, owing to the presence of 'kink' sites.sup.20-22 in the nanoparticles during growth. The presence of chiral components at the inorganic surface of the nanoparticles and in the amino acids and peptides results in enantioselective interactions at the interface between these elements; these interactions lead to asymmetric evolution of the nanoparticles and the formation of helicoid morphologies that consist of highly twisted chiral elements. The gold nanoparticles that we grow display strong chiral plasmonic optical activity (a dis-symmetry factor of 0.2), even when dispersed randomly in solution; this observation is supported by theoretical calculations and direct visualizations of macroscopic colour transformations. We anticipate that our strategy will aid in the rational design and fabrication of three-dimensional chiral nanostructures for use in plasmonic metamaterial applications. Chirality can be 'encoded' into gold nanoparticles by introducing chiral amino acids or peptides during the growth process, leading to the formation of helicoid morphologies., Author(s): Hye-Eun Lee [sup.1] , Hyo-Yong Ahn [sup.1] , Jungho Mun [sup.2] , Yoon Young Lee [sup.1] , Minkyung Kim [sup.3] , Nam Heon Cho [sup.1] , Kiseok Chang [sup.4] [...]