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4. Admission and Care Practices in United States Well Newborn Nurseries.

Author

Joshi, Neha S, Flaherman, Valerie J, Halpern-Felsher, Bonnie, Chung, Esther K, Congdon, Jayme L, and Lee, Henry C

Subjects
Health Services and Systems, Health Sciences, Pediatric, Infant Mortality, Clinical Research, Preterm, Low Birth Weight and Health of the Newborn, Perinatal Period - Conditions Originating in Perinatal Period, Prevention, Reproductive health and childbirth, Good Health and Well Being, Infant, Infant, Newborn, Humans, United States, Nurseries, Infant, Birth Weight, Hospitalization, Gestational Age, Surveys and Questionnaires, Intensive Care Units, Neonatal, Clinical Sciences, Public Health and Health Services, Health services and systems
Abstract

ObjectivesLate preterm and term infants comprise 97.3% of annual births in the United States. Admission criteria and the availability of medical interventions in well newborn nurseries are key determinants of these infants remaining within a mother-infant dyad or requiring a NICU admission and resultant separation of the dyad. The objective of this study was to identify national patterns for well newborn nursery care practices.MethodsWe surveyed a physician representative from each nursery in the Better Outcomes through Research for Newborns Network. We described the admission criteria and clinical management of common newborn morbidities and analyzed associations with nursery demographics.ResultsOf 96 eligible nursery representatives, 69 (72%) completed surveys. Among respondents, 59 (86%) used a minimal birth weight criterion for admission to their well newborn nursery. The most commonly used criteria were 2000 g (n = 29, 49%) and 1800 g (n = 19, 32%), with a range between 1750 and 2500 g. All nurseries used a minimal gestational age criterion for admission; the most commonly used criterion was 35 weeks (n = 55, 80%). Eleven percent of sites required transfer to the NICU for phototherapy. Common interventions in the mother's room included dextrose gel (n = 56, 81%), intravenous antibiotics (n = 35, 51%), opiates for neonatal abstinence syndrome (n = 15, 22%), and an incubator for thermoregulation (n = 14, 20%).ConclusionsWide variation in admission criteria and medical interventions exists in well newborn nurseries. Further studies may help identify evidence-based optimal admission criteria to maximize care within the mother-infant dyad.

Published
2023

7. Addressing bias and knowledge gaps regarding race and ethnicity in neonatology manuscript review

Author

Karvonen, Kayla L, Bonachea, Elizabeth M, Burris, Heather H, Fraiman, Yarden S, Lee, Henry C, Proaño, Alvaro, Walker, Valencia P, and Parker, Margaret G

Subjects
Generic health relevance, Good Health and Well Being, Infant, Newborn, Humans, Ethnicity, Neonatology, Racism, Health Equity, Clinical Sciences, Paediatrics and Reproductive Medicine, Pediatrics
Abstract

A recent shift in public attention to racism, racial disparities, and health equity have resulted in an abundance of calls for relevant papers and publications in academic journals. Peer-review for such articles may be susceptible to bias, as subject matter expertise in the evaluation of social constructs, like race, is variable. From the perspective of researchers focused on neonatal health equity, we share our positive and negative experiences in peer-review, provide relevant publicly available data regarding addressing bias in peer-review from 12 neonatology-focused journals, and give recommendations to address bias and knowledge gaps in the peer review process of health equity research.

Published
2022

14. Risk Factors for Dual Burden of Severe Maternal Morbidity and Preterm Birth by Insurance Type in California

Author

El Ayadi, Alison M, Baer, Rebecca J, Gay, Caryl, Lee, Henry C, Obedin-Maliver, Juno, Jelliffe-Pawlowski, Laura, and Lyndon, Audrey

Subjects
Reproductive Medicine, Midwifery, Biomedical and Clinical Sciences, Health Sciences, Pediatric, Infant Mortality, Perinatal Period - Conditions Originating in Perinatal Period, Cardiovascular, Behavioral and Social Science, Preterm, Low Birth Weight and Health of the Newborn, Prevention, Clinical Research, Reproductive health and childbirth, Good Health and Well Being, Cesarean Section, Female, Humans, Infant, Infant, Newborn, Insurance Coverage, Parity, Pregnancy, Premature Birth, Risk Factors, Severe maternal morbidity, Preterm birth, Health disparities, Insurance coverage, Medical and Health Sciences, Studies in Human Society, Public Health, Biomedical and clinical sciences, Health sciences, Human society
Abstract

ObjectivesAmong childbearing women, insurance coverage determines degree of access to preventive and emergency care for maternal and infant health. Maternal-infant dyads with dual burden of severe maternal morbidity and preterm birth experience high physical and psychological morbidity, and the risk of dual burden varies by insurance type. We examined whether sociodemographic and perinatal risk factors of dual burden differed by insurance type.MethodsWe estimated relative risks of dual burden by maternal sociodemographic and perinatal characteristics in the 2007-2012 California birth cohort dataset stratified by insurance type and compared effects across insurance types using Wald Z-statistics.ResultsDual burden ranged from 0.36% of privately insured births to 0.41% of uninsured births. Obstetric comorbidities, multiple gestation, parity, and birth mode conferred the largest risks across all insurance types, but effect magnitude differed. The adjusted relative risk of dual burden associated with preeclampsia superimposed on preexisting hypertension ranged from 9.1 (95% CI 7.6-10.9) for privately insured to 15.9 (95% CI 9.1-27.6) among uninsured. The adjusted relative risk of dual burden associated with cesarean birth ranged from 3.1 (95% CI 2.7-3.5) for women with Medi-Cal to 5.4 (95% CI 3.5-8.2) for women with other insurance among primiparas, and 7.0 (95% CI 6.0-8.3) to 19.4 (95% CI 10.3-36.3), respectively, among multiparas.ConclusionsRisk factors of dual burden differed by insurance type across sociodemographic and perinatal factors, suggesting that care quality may differ by insurance type. Attention to peripartum care access and care quality provided by insurance type is needed to improve maternal and neonatal health.

Published
2022

16. 2023 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations: Summary From the Basic Life Support; Advanced Life Support; Pediatric Life Support; Neonatal Life Support; Education, Implementation, and Teams; and First Aid Task Forces

Author

Barcala-Furelos, Roberto, Beerman, Stephen B., Bruckner, Marlies, Castrén, Maaret, Chong, ShuLing, Claesson, Andreas, Dunne, Cody L., Finan, Emer, Fukuda, Tatsuma, Lalgudi Ganesan, Saptharishi, Gately, Callum, Gois, Aecio, Gray, Seth, Halamek, Louis P., Hoover, Amber V., Hurst, Cameron, Josephsen, Justin, Kollander, Louise, Omar Kamlin, C., Kool, Mirjam, Li, Lei, Mecrow, Thomas S., Montgomery, William, Ristau, Patrick, Jayashree, Muralidharan, Schmidt, Andrew, Scquizzato, Tommaso, Seesink, Jeroen, Sempsrott, Justin, Lee Solevåg, Anne, Strand, Marya L., Szpilman, David, Szyld, Edgardo, Thom, Ogilvie, Tobin, Joshua M., Trang, Jacinta, Webber, Jonathon, Webster, Hannah K., Wellsford, Michelle, Berg, Katherine M., Bray, Janet E., Ng, Kee-Chong, Liley, Helen G., Greif, Robert, Carlson, Jestin N., Morley, Peter T., Drennan, Ian R., Smyth, Michael, Scholefield, Barnaby R., Weiner, Gary M., Cheng, Adam, Djärv, Therese, Abelairas-Gómez, Cristian, Acworth, Jason, Andersen, Lars W., Atkins, Dianne L., Berry, David C., Bhanji, Farhan, Bierens, Joost, Bittencourt Couto, Thomaz, Borra, Vere, Böttiger, Bernd W., Bradley, Richard N., Breckwoldt, Jan, Cassan, Pascal, Chang, Wei-Tien, Charlton, Nathan P., Chung, Sung Phil, Considine, Julie, Costa-Nobre, Daniela T., Couper, Keith, Dainty, Katie N., Dassanayake, Vihara, Davis, Peter G., Dawson, Jennifer A., Fernanda de Almeida, Maria, De Caen, Allan R., Deakin, Charles D., Dicker, Bridget, Douma, Matthew J., Eastwood, Kathryn, El-Naggar, Walid, Fabres, Jorge G., Fawke, Joe, Fijacko, Nino, Finn, Judith C., Flores, Gustavo E., Foglia, Elizabeth E., Folke, Fredrik, Gilfoyle, Elaine, Goolsby, Craig A., Granfeldt, Asger, Guerguerian, Anne-Marie, Guinsburg, Ruth, Hatanaka, Tetsuo, Hirsch, Karen G., Holmberg, Mathias J., Hosono, Shigeharu, Hsieh, Ming-Ju, Hsu, Cindy H., Ikeyama, Takanari, Isayama, Tetsuya, Johnson, Nicholas J., Kapadia, Vishal S., Daripa Kawakami, Mandira, Kim, Han-Suk, Kleinman, Monica E., Kloeck, David A., Kudenchuk, Peter, Kule, Amy, Kurosawa, Hiroshi, Lagina, Anthony T., Lauridsen, Kasper G., Lavonas, Eric J., Lee, Henry C., Lin, Yiqun, Lockey, Andrew S., Macneil, Finlay, Maconochie, Ian K., John Madar, R., Malta Hansen, Carolina, Masterson, Siobhan, Matsuyama, Tasuku, McKinlay, Christopher J.D., Meyran, Daniel, Monnelly, Vix, Nadkarni, Vinay, Nakwa, Firdose L., Nation, Kevin J., Nehme, Ziad, Nemeth, Michael, Neumar, Robert W., Nicholson, Tonia, Nikolaou, Nikolaos, Nishiyama, Chika, Norii, Tatsuya, Nuthall, Gabrielle A., Ohshimo, Shinchiro, Olasveengen, Theresa M., Gene Ong, Yong-Kwang, Orkin, Aaron M., Parr, Michael J., Patocka, Catherine, Perkins, Gavin D., Perlman, Jeffrey M., Rabi, Yacov, Raitt, James, Ramachandran, Shalini, Ramaswamy, Viraraghavan V., Raymond, Tia T., Reis, Amelia G., Reynolds, Joshua C., Ristagno, Giuseppe, Rodriguez-Nunez, Antonio, Roehr, Charles C., Rüdiger, Mario, Sakamoto, Tetsuya, Sandroni, Claudio, Sawyer, Taylor L., Schexnayder, Steve M., Schmölzer, Georg M., Schnaubelt, Sebastian, Semeraro, Federico, Singletary, Eunice M., Skrifvars, Markus B., Smith, Christopher M., Soar, Jasmeet, Stassen, Willem, Sugiura, Takahiro, Tijssen, Janice A., Topjian, Alexis A., Trevisanuto, Daniele, Vaillancourt, Christian, Wyckoff, Myra H., Wyllie, Jonathan P., Yang, Chih-Wei, Yeung, Joyce, Zelop, Carolyn M., Zideman, David A., and Nolan, Jerry P.

Published
2024
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17. 2024 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations: Summary From the Basic Life Support; Advanced Life Support; Pediatric Life Support; Neonatal Life Support; Education, Implementation, and Teams; and First Aid Task Forces

Author

Greif, Robert, Bray, Janet E., Djärv, Therese, Drennan, Ian R., Liley, Helen G., Ng, Kee-Chong, Cheng, Adam, Douma, Matthew J., Scholefield, Barnaby R., Smyth, Michael, Weiner, Gary, Abelairas-Gómez, Cristian, Acworth, Jason, Anderson, Natalie, Atkins, Dianne L., Berry, David C., Bhanji, Farhan, Böttiger, Bernd W., Bradley, Richard N., Breckwoldt, Jan, Carlson, Jestin N., Cassan, Pascal, Chang, Wei-Tien, Charlton, Nathan P., Phil Chung, Sung, Considine, Julie, Cortegiani, Andrea, Costa-Nobre, Daniela T., Couper, Keith, Bittencourt Couto, Thomaz, Dainty, Katie N., Dassanayake, Vihara, Davis, Peter G., Dawson, Jennifer A., de Caen, Allan R., Deakin, Charles D., Debaty, Guillaume, del Castillo, Jimena, Dewan, Maya, Dicker, Bridget, Djakow, Jana, Donoghue, Aaron J., Eastwood, Kathryn, El-Naggar, Walid, Escalante-Kanashiro, Raffo, Fabres, Jorge, Farquharson, Barbara, Fawke, Joe, Fernanda de Almeida, Maria, Fernando, Shannon M., Finan, Emer, Finn, Judith, Flores, Gustavo E., Foglia, Elizabeth E., Folke, Fredrik, Goolsby, Craig A., Granfeldt, Asger, Guerguerian, Anne-Marie, Guinsburg, Ruth, Malta Hansen, Carolina, Hatanaka, Tetsuo, Hirsch, Karen G., Holmberg, Mathias J., Hooper, Stuart, Hoover, Amber V., Hsieh, Ming-Ju, Ikeyama, Takanari, Isayama, Tetsuya, Johnson, Nicholas J., Josephsen, Justin, Katheria, Anup, Kawakami, Mandira D., Kleinman, Monica, Kloeck, David, Ko, Ying-Chih, Kudenchuk, Peter, Kule, Amy, Kurosawa, Hiroshi, Laermans, Jorien, Lagina, Anthony, Lauridsen, Kasper G., Lavonas, Eric J., Lee, Henry C., Han Lim, Swee, Lin, Yiqun, Lockey, Andrew S., Lopez-Herce, Jesus, Lukas, George, Macneil, Finlay, Maconochie, Ian K., Madar, John, Martinez-Mejas, Abel, Masterson, Siobhan, Matsuyama, Tasuku, Mausling, Richard, McKinlay, Christopher J.D., Meyran, Daniel, Montgomery, William, Morley, Peter T., Morrison, Laurie J., Moskowitz, Ari L., Myburgh, Michelle, Nabecker, Sabine, Nadkarni, Vinay, Nakwa, Firdose, Nation, Kevin J., Nehme, Ziad, Nicholson, Tonia, Nikolaou, Nikolaos, Nishiyama, Chika, Norii, Tatsuya, Nuthall, Gabrielle, Ohshimo, Shinichiro, Olasveengen, Theresa, Olaussen, Alexander, Ong, Gene, Orkin, Aaron, Parr, Michael J., Perkins, Gavin D., Pocock, Helen, Rabi, Yacov, Raffay, Violetta, Raitt, James, Raymond, Tia, Ristagno, Giuseppe, Rodriguez-Nunez, Antonio, Rossano, Joseph, Rüdiger, Mario, Sandroni, Claudio, Sawyer, Taylor L., Schexnayder, Stephen M., Schmölzer, Georg, Schnaubelt, Sebastian, Lene Seidler, Anna, Semeraro, Federico, Singletary, Eunice M., Skrifvars, Markus B., Smith, Christopher M., Soar, Jasmeet, Lee Solevåg, Anne, Soll, Roger, Stassen, Willem, Sugiura, Takahiro, Thilakasiri, Kaushila, Tijssen, Janice, Kumar Tiwari, Lokesh, Topjian, Alexis, Trevisanuto, Daniele, Vaillancourt, Christian, Welsford, Michelle, Wyckoff, Myra H., Yang, Chih-Wei, Yeung, Joyce, Zelop, Carolyn M., Zideman, David A., Nolan, Jerry P., and Berg, Katherine M.

Published
2024
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22. 2023 American Heart Association and American Academy of Pediatrics Focused Update on Neonatal Resuscitation: An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care

Author

Yamada, Nicole K., Szyld, Edgardo, Strand, Marya L., Finan, Emer, Illuzzi, Jessica L., Kamath-Rayne, Beena D., Kapadia, Vishal S., Niermeyer, Susan, Schmölzer, Georg M., Williams, Amanda, Weiner, Gary M., Wyckoff, Myra H., and Lee, Henry C.

Published
2024
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24. 2023 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations: Summary From the Basic Life Support; Advanced Life Support; Pediatric Life Support; Neonatal Life Support; Education, Implementation, and Teams; and First Aid Task Forces

Author

Berg, Katherine M., Bray, Janet E., Ng, Kee-Chong, Liley, Helen G., Greif, Robert, Carlson, Jestin N., Morley, Peter T., Drennan, Ian R., Smyth, Michael, Scholefield, Barnaby R., Weiner, Gary M., Cheng, Adam, Djärv, Therese, Abelairas-Gómez, Cristian, Acworth, Jason, Andersen, Lars W., Atkins, Dianne L., Berry, David C., Bhanji, Farhan, Bierens, Joost, Bittencourt Couto, Thomaz, Borra, Vere, Böttiger, Bernd W., Bradley, Richard N., Breckwoldt, Jan, Cassan, Pascal, Chang, Wei-Tien, Charlton, Nathan P., Chung, Sung Phil, Considine, Julie, Costa-Nobre, Daniela T., Couper, Keith, Dainty, Katie N., Dassanayake, Vihara, Davis, Peter G., Dawson, Jennifer A., de Almeida, Maria Fernanda, De Caen, Allan R., Deakin, Charles D., Dicker, Bridget, Douma, Matthew J., Eastwood, Kathryn, El-Naggar, Walid, Fabres, Jorge G., Fawke, Joe, Fijacko, Nino, Finn, Judith C., Flores, Gustavo E., Foglia, Elizabeth E., Folke, Fredrik, Gilfoyle, Elaine, Goolsby, Craig A., Granfeldt, Asger, Guerguerian, Anne-Marie, Guinsburg, Ruth, Hatanaka, Tetsuo, Hirsch, Karen G., Holmberg, Mathias J., Hosono, Shigeharu, Hsieh, Ming-Ju, Hsu, Cindy H., Ikeyama, Takanari, Isayama, Tetsuya, Johnson, Nicholas J., Kapadia, Vishal S., Kawakami, Mandira Daripa, Kim, Han-Suk, Kleinman, Monica E., Kloeck, David A., Ko, Ying-Chih, Kudenchuk, Peter, Kule, Amy, Kurosawa, Hiroshi, Lagina, Anthony T., Lauridsen, Kasper G., Lavonas, Eric J., Lee, Henry C., Lin, Yiqun, Lockey, Andrew S., Macneil, Finlay, Maconochie, Ian K., Madar, R. John, Malta Hansen, Carolina, Masterson, Siobhan, Matsuyama, Tasuku, McKinlay, Christopher J.D., Meyran, Daniel, Monnelly, Vix, Morrison, Laurie J., Nadkarni, Vinay, Nakwa, Firdose L., Nation, Kevin J., Nehme, Ziad, Nemeth, Michael, Neumar, Robert W., Nicholson, Tonia, Nikolaou, Nikolaos, Nishiyama, Chika, Norii, Tatsuya, Nuthall, Gabrielle A., Ohshimo, Shinchiro, Olasveengen, Theresa M., Ong, Yong-Kwang Gene, Orkin, Aaron M., Parr, Michael J., Patocka, Catherine, Perkins, Gavin D., Perlman, Jeffrey M., Rabi, Yacov, Raitt, James, Ramachandran, Shalini, Ramaswamy, Viraraghavan V., Raymond, Tia T., Reis, Amelia G., Reynolds, Joshua C., Ristagno, Giuseppe, Rodriguez-Nunez, Antonio, Roehr, Charles C., Rüdiger, Mario, Sakamoto, Tetsuya, Sandroni, Claudio, Sawyer, Taylor L., Schexnayder, Steve M., Schmölzer, Georg M., Schnaubelt, Sebastian, Semeraro, Federico, Singletary, Eunice M., Skrifvars, Markus B., Smith, Christopher M., Soar, Jasmeet, Stassen, Willem, Sugiura, Takahiro, Tijssen, Janice A., Topjian, Alexis A., Trevisanuto, Daniele, Vaillancourt, Christian, Wyckoff, Myra H., Wyllie, Jonathan P., Yang, Chih-Wei, Yeung, Joyce, Zelop, Carolyn M., Zideman, David A., Nolan, Jerry P., Barcala-Furelos, Roberto, Beerman, Stephen B., Castrén, Maaret, Chong, ShuLing, Claesson, Andreas, Dunne, Cody L., Ersdal, Hege L., Finan, Emer, Fuerch, Janene, Fukuda, Tatsuma, Ganesan, Saptharishi Lalgudi, Gately, Callum, Gray, Seth, Halamek, Louis P., Hoover, Amber V., Kollander, Louise, Kamlin, C. Omar, Koo, Mirjam, Li, Lei, Leone, Tina A., Mecrow, s, Montgomery, William, Ristau, Patrick, Jayashree, Muralidharan, Quek, Bin Huey, Schmidt, Andrew, Scquizzato, Tommaso, Seesink, Jeroen, Sempsrott, Justin, Shah, Birju A., Strand, Marya L., Szpilman, David, Szyld, Edgardo, Thio, Marta, Thom, Ogilvie, Tobin, Joshua M., Udaeta, Enrique, Webber, Jonathon, Webster, Hannah K., Wellsford, Michelle, and Yamada, Nicole K.

Published
2023
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25. 2023 American Heart Association and American Academy of Pediatrics Focused Update on Neonatal Resuscitation: An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care

Author

Yamada, Nicole K., Szyld, Edgardo, Strand, Marya L., Finan, Emer, Illuzzi, Jessica L., Kamath-Rayne, Beena D., Kapadia, Vishal S., Niermeyer, Susan, Schmölzer, Georg M., Williams, Amanda, Weiner, Gary M., Wyckoff, Myra H., and Lee, Henry C.

Published
2023
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27. Medical Device Design Education: Identifying Problems through Observation and Hands-On Training

Author

Sherman, Jules, Lee, Henry C., Weiss, Madeleine Eva, and Kristensen-Cabrera, Alexandria

Abstract

Experiential learning, which may include hands-on learning paired with observation and reflection, has been applied in several industries; however, the impact of experiential learning in design education is not well known. We investigated how the type of simulation-based learning could affect the acquisition of knowledge and the ability to synthesize that understanding into insights for medical design innovation. One workshop included observational learning and the other experiential learning with hands-on training. Each course included 14-16 multidisciplinary undergraduate and graduate students. During both workshops, we measured student comprehension of two procedures--infant resuscitation and management of maternal hemorrhage. We focused on the first two phases of design thinking: "Understanding" and "Defining the Problems". Although the course focused on "medical device design", we encouraged students to look beyond the tool to imagine how their design change could impact the entire system. We did not find a significant difference between the scores given to students in the two courses by industry experts. Although the quality of the ideas and execution were similar between both workshops, the instructors noticed that the integration of hands-on training into the second workshop created a higher level of excitement in the class. The methodology and the approach adopted may be relevant to many design problems. In order to better understand the impact of observational learning versus hands-on training, both workshops could be expanded into full quarter classes that allow students to expand their design thinking skills to prototype and test their ideas in the real world.

Published
2018

28. Stillbirths and live births in the periviable period

Author

Elser, Holly, Gemmill, Alison, Casey, Joan A, Karasek, Deborah, Bruckner, Tim, Mayo, Jonathan A, Lee, Henry C, Stevenson, David K, Shaw, Gary M, and Catalano, Ralph

Subjects
Paediatrics, Biomedical and Clinical Sciences, Pediatric, Good Health and Well Being, Adult, California, Cohort Studies, Female, Gestational Age, Humans, Infant, Newborn, Live Birth, Pregnancy, Pregnancy Trimester, Second, Stillbirth, United States, Periviable, Evidence-based medicine, Medical and Health Sciences, Epidemiology, Biomedical and clinical sciences, Health sciences
Abstract

PurposeWe use data from California, where 13% of US births occur, to address two questions arising from efforts in the first decade of this century to avoid stillbirths before 25 6/7 weeks of gestation (i.e., in the periviable period). First, did stillbirths decline in the first decade of this century? Second, if stillbirths did decline, did periviable live births increase simultaneously? Answering these questions is important given that periviable infants represent less than 1% of live births but account for roughly 40% of infant mortality and 20% of hospital-based obstetric costs in the United States.MethodsWe constructed 240 monthly conception cohorts, starting with that conceived in January 1991, from 9,880,536 singleton pregnancies that reached the 20 0/7 week of gestation. We used time-series design and Box-Jenkins methods that address confounding by autocorrelation, including secular trends and seasonality to answer our questions.ResultsWe detected a downward shift in stillbirths in April 2007 that coincided with an upward shift in periviable live births.ConclusionsOur findings imply that, since 2007, fewer Californians than expected from history and from the size of conception cohorts reaching 20 0/7 weeks of gestation have had to contend with the sequelae of stillbirths, but more than expected likely have had to contend with those of periviable births.

Published
2020

29. Maternal and infant predictors of infant mortality in California, 2007–2015

Author

Ratnasiri, Anura WG, Lakshminrusimha, Satyan, Dieckmann, Ronald A, Lee, Henry C, Gould, Jeffrey B, Parry, Steven S, Arief, Vivi N, DeLacy, Ian H, DiLibero, Ralph J, and Basford, Kaye E

Subjects
Biomedical and Clinical Sciences, Midwifery, Public Health, Health Sciences, Paediatrics, Reproductive Medicine, Preterm, Low Birth Weight and Health of the Newborn, Perinatal Period - Conditions Originating in Perinatal Period, Pediatric, Clinical Research, Prevention, Infant Mortality, Reproductive health and childbirth, Good Health and Well Being, Adult, Analysis of Variance, California, Cohort Studies, Educational Status, Ethnicity, Female, Humans, Infant, Male, Middle Aged, Mothers, Obesity, Racial Groups, Retrospective Studies, Smoking, Socioeconomic Factors, Young Adult, General Science & Technology
Abstract

ObjectiveTo identify current maternal and infant predictors of infant mortality, including maternal sociodemographic and economic status, maternal perinatal smoking and obesity, mode of delivery, and infant birthweight and gestational age.MethodsThis retrospective study analyzed data from the linked birth and infant death files (birth cohort) and live births from the Birth Statistical Master files (BSMF) in California compiled by the California Department of Public Health for 2007-2015. The birth cohort study comprised 4,503,197 singleton births including 19,301 infant deaths during the nine-year study period. A subpopulation to study fetal growth consisted of 4,448,300 birth cohort records including 13,891 infant deaths.ResultsThe infant mortality rate (IMR) for singleton births decreased linearly (p

Published
2020

35. Corrigendum to “2022 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations: Summary From the Basic Life Support; Advanced Life Support; Pediatric Life Support; Neonatal Life Support; Education, Implementation, and Teams; and First Aid Task Forces” [Resuscitation 181 (2022) 208–288]

Author

Wyckoff, Myra H., primary, Greif, Robert, additional, Morley, Peter T., additional, Ng, Kee-Chong, additional, Olasveengen, Theresa M., additional, Singletary, Eunice M., additional, Soar, Jasmeet, additional, Cheng, Adam, additional, Drennan, Ian R., additional, Liley, Helen G., additional, Scholefield, Barnaby R., additional, Smyth, Michael A., additional, Welsford, Michelle, additional, Zideman, David A., additional, Acworth, Jason, additional, Aickin, Richard, additional, Andersen, Lars W., additional, Atkins, Diane, additional, Berry, David C., additional, Bhanji, Farhan, additional, Bierens, Joost, additional, Borra, Vere, additional, Böttiger, Bernd W., additional, Bradley, Richard N., additional, Bray, Janet E., additional, Breckwoldt, Jan, additional, Callaway, Clifton W., additional, Carlson, Jestin N., additional, Cassan, Pascal, additional, Castrén, Maaret, additional, Chang, Wei-Tien, additional, Charlton, Nathan P., additional, Chung, Sung Phil, additional, Considine, Julie, additional, Costa-Nobre, Daniela T., additional, Couper, Keith, additional, Couto, Thomaz Bittencourt, additional, Dainty, Katie N., additional, Davis, Peter G., additional, de Almeida, Maria Fernanda, additional, de Caen, Allan R., additional, Deakin, Charles D., additional, Djärv, Therese, additional, Donnino, Michael W., additional, Douma, Matthew J., additional, Duff, Jonathan P., additional, Dunne, Cody L., additional, Eastwood, Kathryn, additional, El-Naggar, Walid, additional, Fabres, Jorge G., additional, Fawke, Joe, additional, Finn, Judith, additional, Foglia, Elizabeth E., additional, Folke, Fredrik, additional, Gilfoyle, Elaine, additional, Goolsby, Craig A., additional, Granfeldt, Asger, additional, Guerguerian, Anne-Marie, additional, Guinsburg, Ruth, additional, Hirsch, Karen G., additional, Holmberg, Mathias J., additional, Hosono, Shigeharu, additional, Hsieh, Ming-Ju, additional, Hsu, Cindy H., additional, Ikeyama, Takanari, additional, Isayama, Tetsuya, additional, Johnson, Nicholas J., additional, Kapadia, Vishal S., additional, Daripa Kawakami, Mandira, additional, Kim, Han-Suk, additional, Kleinman, Monica, additional, Kloeck, David A., additional, Kudenchuk, Peter J., additional, Lagina, Anthony T., additional, Lauridsen, Kasper G., additional, Lavonas, Eric J., additional, Lee, Henry C., additional, (Jeffrey) Lin, Yiqun, additional, Lockey, Andrew S., additional, Maconochie, Ian K., additional, John Madar, R., additional, Hansen, Carolina Malta, additional, Masterson, Siobhan, additional, Matsuyama, Tasuku, additional, McKinlay, Christopher J.D., additional, Meyran, Daniel, additional, Morgan, Patrick, additional, Morrison, Laurie J., additional, Nadkarni, Vinay, additional, Nakwa, Firdose L., additional, Nation, Kevin J., additional, Nehme, Ziad, additional, Nemeth, Michael, additional, Neumar, Robert W., additional, Nicholson, Tonia, additional, Nikolaou, Nikolaos, additional, Nishiyama, Chika, additional, Norii, Tatsuya, additional, Nuthall, Gabrielle A., additional, O'Neill, Brian J., additional, Gene Ong, Yong-Kwang, additional, Orkin, Aaron M., additional, Paiva, Edison F., additional, Parr, Michael J., additional, Patocka, Catherine, additional, Pellegrino, Jeffrey L., additional, Perkins, Gavin D., additional, Perlman, Jeffrey M., additional, Rabi, Yacov, additional, Reis, Amelia G., additional, Reynolds, Joshua C., additional, Ristagno, Giuseppe, additional, Rodriguez-Nunez, Antonio, additional, Roehr, Charles C., additional, Rüdiger, Mario, additional, Sakamoto, Tetsuya, additional, Sandroni, Claudio, additional, Sawyer, Taylor L., additional, Schexnayder, Steve M., additional, Schmölzer, Georg M., additional, Schnaubelt, Sebastian, additional, Semeraro, Federico, additional, Skrifvars, Markus B., additional, Smith, Christopher M., additional, Sugiura, Takahiro, additional, Tijssen, Janice A., additional, Trevisanuto, Daniele, additional, Van de Voorde, Patrick, additional, Wang, Tzong-Luen, additional, Weiner, Gary M., additional, Wyllie, Jonathan P., additional, Yang, Chih-Wei, additional, Yeung, Joyce, additional, Nolan, Jerry P., additional, Berg, Katherine M., additional, Burdick, Madeline C., additional, Cartledge, Susie, additional, Dawson, Jennifer A., additional, Elgohary, Moustafa M., additional, Ersdal, Hege L., additional, Finan, Emer, additional, Flaatten, Hilde I., additional, Flores, Gustavo E., additional, Fuerch, Janene, additional, Garg, Rakesh, additional, Gately, Callum, additional, Goh, Mark, additional, Halamek, Louis P., additional, Handley, Anthony J., additional, Hatanaka, Tetsuo, additional, Hoover, Amber, additional, Issa, Mohmoud, additional, Johnson, Samantha, additional, Kamlin, C. Omar, additional, Ko, Ying-Chih, additional, Kule, Amy, additional, Leone, Tina A., additional, MacKenzie, Ella, additional, Macneil, Finlay, additional, Montgomery, William, additional, O'Dochartaigh, Domhnall, additional, Ohshimo, Shinichiro, additional, Palazzo, Francesco Stefano, additional, Picard, Christopher, additional, Quek, Bin Huey, additional, Raitt, James, additional, Ramaswamy, Viraraghavan V., additional, Scapigliati, Andrea, additional, Shah, Birju A., additional, Stewart, Craig, additional, Strand, Marya L., additional, Szyld, Edgardo, additional, Thio, Marta, additional, Topjian, Alexis A., additional, Udaeta, Enrique, additional, Vaillancourt, Christian, additional, Wetsch, Wolfgang A., additional, Wigginton, Jane, additional, Yamada, Nicole K., additional, Yao, Sarah, additional, Zace, Drieda, additional, and Zelop, Carolyn M., additional

Published
2024
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40. 2022 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations: Summary From the Basic Life Support; Advanced Life Support; Pediatric Life Support; Neonatal Life Support; Education, Implementation, and Teams; and First Aid Task Forces

Author

Burdick, Madeline C., Cartledge, Susie, Dawson, Jennifer A., Elgohary, Moustafa M., Ersdal, Hege L., Finan, Emer, Flaatten, Hilde I., Flores, Gustavo E., Fuerch, Janene, Garg, Rakesh, Gately, Callum, Goh, Mark, Halamek, Louis P., Handley, Anthony J., Hatanaka, Tetsuo, Hoover, Amber, Issa, Mohmoud, Johnson, Samantha, Kamlin, C. Omar, Ko, Ying-Chih, Kule, Amy, Leone, Tina A., MacKenzie, Ella, Macneil, Finlay, Montgomery, William, O’Dochartaigh, Domhnall, Ohshimo, Shinichiro, Stefano Palazzo, Francesco, Picard, Christopher, Quek, Bin Huey, Raitt, James, Ramaswamy, Viraraghavan V., Scapigliati, Andrea, Shah, Birju A., Stewart, Craig, Strand, Marya L., Szyld, Edgardo, Thio, Marta, Topjian, Alexis A., Udaeta, Enrique, Vaillancourt, Christian, Wetsch, Wolfgang A., Wigginton, Jane, Yamada, Nicole K., Yao, Sarah, Zace, Drieda, Zelop, Carolyn M., Wyckoff, Myra H., Greif, Robert, Morley, Peter T., Ng, Kee-Chong, Olasveengen, Theresa M., Singletary, Eunice M., Soar, Jasmeet, Cheng, Adam, Drennan, Ian R., Liley, Helen G., Scholefield, Barnaby R., Smyth, Michael A., Welsford, Michelle, Zideman, David A., Acworth, Jason, Aickin, Richard, Andersen, Lars W., Atkins, Diane, Berry, David C., Bhanji, Farhan, Bierens, Joost, Borra, Vere, Böttiger, Bernd W., Bradley, Richard N., Bray, Janet E., Breckwoldt, Jan, Callaway, Clifton W., Carlson, Jestin N., Cassan, Pascal, Castrén, Maaret, Chang, Wei-Tien, Charlton, Nathan P., Phil Chung, Sung, Considine, Julie, Costa-Nobre, Daniela T., Couper, Keith, Couto, Thomaz Bittencourt, Dainty, Katie N., Davis, Peter G., de Almeida, Maria Fernanda, de Caen, Allan R., Deakin, Charles D., Djärv, Therese, Donnino, Michael W., Douma, Matthew J., Duff, Jonathan P., Dunne, Cody L., Eastwood, Kathryn, El-Naggar, Walid, Fabres, Jorge G., Fawke, Joe, Finn, Judith, Foglia, Elizabeth E., Folke, Fredrik, Gilfoyle, Elaine, Goolsby, Craig A., Granfeldt, Asger, Guerguerian, Anne-Marie, Guinsburg, Ruth, Hirsch, Karen G., Holmberg, Mathias J., Hosono, Shigeharu, Hsieh, Ming-Ju, Hsu, Cindy H., Ikeyama, Takanari, Isayama, Tetsuya, Johnson, Nicholas J., Kapadia, Vishal S., Kawakami, Mandira Daripa, Kim, Han-Suk, Kleinman, Monica, Kloeck, David A., Kudenchuk, Peter J., Lagina, Anthony T., Lauridsen, Kasper G., Lavonas, Eric J., Lee, Henry C., Lin, Yiqun (Jeffrey), Lockey, Andrew S., Maconochie, Ian K., Madar, R. John, Malta Hansen, Carolina, Masterson, Siobhan, Matsuyama, Tasuku, McKinlay, Christopher J.D., Meyran, Daniel, Morgan, Patrick, Morrison, Laurie J., Nadkarni, Vinay, Nakwa, Firdose L., Nation, Kevin J., Nehme, Ziad, Nemeth, Michael, Neumar, Robert W., Nicholson, Tonia, Nikolaou, Nikolaos, Nishiyama, Chika, Norii, Tatsuya, Nuthall, Gabrielle A., O’Neill, Brian J., Gene Ong, Yong-Kwang, Orkin, Aaron M., Paiva, Edison F., Parr, Michael J., Patocka, Catherine, Pellegrino, Jeffrey L., Perkins, Gavin D., Perlman, Jeffrey M., Rabi, Yacov, Reis, Amelia G., Reynolds, Joshua C., Ristagno, Giuseppe, Rodriguez-Nunez, Antonio, Roehr, Charles C., Rüdiger, Mario, Sakamoto, Tetsuya, Sandroni, Claudio, Sawyer, Taylor L., Schexnayder, Steve M., Schmölzer, Georg M., Schnaubelt, Sebastian, Semeraro, Federico, Skrifvars, Markus B., Smith, Christopher M., Sugiura, Takahiro, Tijssen, Janice A., Trevisanuto, Daniele, Van de Voorde, Patrick, Wang, Tzong-Luen, Weiner, Gary M., Wyllie, Jonathan P., Yang, Chih-Wei, Yeung, Joyce, Nolan, Jerry P., and Berg, Katherine M.

Published
2022
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41. Racial/Ethnic Disparities in Neonatal Intensive Care: A Systematic Review

Author

Sigurdson, Krista, Mitchell, Briana, Liu, Jessica, Morton, Christine, Gould, Jeffrey B, Lee, Henry C, Capdarest-Arest, Nicole, and Profit, Jochen

Subjects
Paediatrics, Biomedical and Clinical Sciences, Health Sciences, Health Services, Infant Mortality, Perinatal Period - Conditions Originating in Perinatal Period, Clinical Research, Pediatric, Good Health and Well Being, Ethnicity, Healthcare Disparities, Humans, Infant, Newborn, Intensive Care Units, Neonatal, Intensive Care, Neonatal, Quality of Health Care, Racial Groups, Medical and Health Sciences, Psychology and Cognitive Sciences, Pediatrics, Biomedical and clinical sciences, Health sciences, Psychology
Abstract

Racial and ethnic disparities in health outcomes of newborns requiring care in the NICU setting have been reported. The contribution of NICU care to disparities in outcomes is unclear. To conduct a systematic review of the literature documenting racial/ethnic disparities in quality of care for infants in the NICU setting. Medline/PubMed, Scopus, Cumulative Index of Nursing and Allied Health, and Web of Science were searched until March 6, 2018, by using search queries organized around the following key concepts: "neonatal intensive care units," "racial or ethnic disparities," and "quality of care." English language articles up to March 6, 2018, that were focused on racial and/or ethnic differences in the quality of NICU care were selected. Two authors independently assessed eligibility, extracted data, and cross-checked results, with disagreements resolved by consensus. Information extracted focused on racial and/or ethnic disparities in quality of care and potential mechanism(s) for disparities. Initial search yielded 566 records, 470 of which were unique citations. Title and abstract review resulted in 382 records. Appraisal of the full text of the remaining 88 records, along with the addition of 5 citations from expert consult or review of bibliographies, resulted in 41 articles being included. Quantitative meta-analysis was not possible because of study heterogeneity. Overall, this systematic review revealed complex racial and/or ethnic disparities in structure, process, and outcome measures, most often disadvantaging infants of color, especially African American infants. There are some exceptions to this pattern and each area merits its own analysis and discussion.

Published
2019

43. Trends in maternal prepregnancy body mass index (BMI) and its association with birth and maternal outcomes in California, 2007-2016: A retrospective cohort study.

Author

Ratnasiri, Anura WG, Lee, Henry C, Lakshminrusimha, Satyan, Parry, Steven S, Arief, Vivi N, DeLacy, Ian H, Yang, Jo-Shing, DiLibero, Ralph J, Logan, Julia, and Basford, Kaye E

Subjects
Humans, Body Mass Index, Pregnancy Outcome, Prevalence, Retrospective Studies, Pregnancy, Adult, California, Female, Overweight, Obesity, Maternal, Obesity, Maternal, General Science & Technology
Abstract

ObjectiveTo determine recent trends in maternal prepregnancy body mass index (BMI) and to quantify its association with birth and maternal outcomes.MethodsA population-based retrospective cohort study included resident women with singleton births in the California Birth Statistical Master Files (BSMF) database from 2007 to 2016. There were 4,621,082 women included out of 5,054,968 women registered in the database. 433,886 (8.6%) women were excluded due to invalid or missing information for BMI. Exposures were underweight (BMI < 18.5 kg/m2), normal weight (18.5-24.9 kg/m2), overweight (25.0-29.9 kg/m2), and obese (≥ 30 kg/m2) at the onset of pregnancy. Obesity was subcategorized into class I (30.0-34.9 kg/m2), class II (35.0-39.9 kg/m2), and class III (≥ 40 kg/m2), while adverse outcomes examined were low birth weight (LBW), very low birth weight (VLBW), macrosomic births, preterm birth (PTB), very preterm birth (VPTB), small-for-gestational-age birth (SGA), large-for-gestational-age birth (LGA), and cesarean delivery (CD). Descriptive analysis, simple linear regression, and multivariate logistic regression were performed, and adjusted odds ratios (AORs) with 95% confidence intervals (CIs) for associations were estimated.ResultsOver the ten-year study period, the prevalence of underweight and normal weight women at time of birth declined by 10.6% and 9.7%, respectively, while the prevalence of overweight and obese increased by 4.3% and 22.9%, respectively. VLBW increased significantly with increasing BMI, by 24% in overweight women and by 76% in women with class III obesity from 2007 to 2016. Women with class III obesity also had a significant increase in macrosomic birth (170%) and were more likely to deliver PTB (33%), VPTB (66%), LGA (231%), and CD (208%) than women with a normal BMI. However, obese women were less likely to have SGA infants; underweight women were 51% more likely to have SGA infants than women with a normal BMI.ConclusionsIn California from 2007 to 2016, there was a declining trend in women with prepregnancy normal weight, and a rising trend in overweight and obese women, particularly obesity class III. Both extremes of prepregnancy BMI were associated with an increased incidence of adverse neonatal outcomes; however, the worse outcomes were prominent in those women classified as obese.

Published
2019

49. 2022 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations: Summary From the Basic Life Support; Advanced Life Support; Pediatric Life Support; Neonatal Life Support; Education, Implementation, and Teams; and First Aid Task Forces

Author

Wyckoff, Myra H., Greif, Robert, Morley, Peter T., Ng, Kee-Chong, Olasveengen, Theresa M., Singletary, Eunice M., Soar, Jasmeet, Cheng, Adam, Drennan, Ian R., Liley, Helen G., Scholefield, Barnaby R., Smyth, Michael A., Welsford, Michelle, Zideman, David A., Acworth, Jason, Aickin, Richard, Andersen, Lars W., Atkins, Diane, Berry, David C., Bhanji, Farhan, Bierens, Joost, Borra, Vere, Böttiger, Bernd W., Bradley, Richard N., Bray, Janet E., Breckwoldt, Jan, Callaway, Clifton W., Carlson, Jestin N., Cassan, Pascal, Castrén, Maaret, Chang, Wei-Tien, Charlton, Nathan P., Chung, Sung Phil, Considine, Julie, Costa-Nobre, Daniela T., Couper, Keith, Couto, Thomaz Bittencourt, Dainty, Katie N., Davis, Peter G., de Almeida, Maria Fernanda, de Caen, Allan R., Deakin, Charles D., Djärv, Therese, Donnino, Michael W., Douma, Matthew J., Duff, Jonathan P., Dunne, Cody L., Eastwood, Kathryn, El-Naggar, Walid, Fabres, Jorge G., Fawke, Joe, Finn, Judith, Foglia, Elizabeth E., Folke, Fredrik, Gilfoyle, Elaine, Goolsby, Craig A., Granfeldt, Asger, Guerguerian, Anne-Marie, Guinsburg, Ruth, Hirsch, Karen G., Holmberg, Mathias J., Hosono, Shigeharu, Hsieh, Ming-Ju, Hsu, Cindy H., Ikeyama, Takanari, Isayama, Tetsuya, Johnson, Nicholas J., Kapadia, Vishal S., Kawakami, Mandira Daripa, Kim, Han-Suk, Kleinman, Monica, Kloeck, David A., Kudenchuk, Peter J., Lagina, Anthony T., Lauridsen, Kasper G., Lavonas, Eric J., Lee, Henry C., Lin, Yiqun (Jeffrey), Lockey, Andrew S., Maconochie, Ian K., Madar, R. John, Malta Hansen, Carolina, Masterson, Siobhan, Matsuyama, Tasuku, McKinlay, Christopher J.D., Meyran, Daniel, Morgan, Patrick, Morrison, Laurie J., Nadkarni, Vinay, Nakwa, Firdose L., Nation, Kevin J., Nehme, Ziad, Nemeth, Michael, Neumar, Robert W., Nicholson, Tonia, Nikolaou, Nikolaos, Nishiyama, Chika, Norii, Tatsuya, Nuthall, Gabrielle A., O’Neill, Brian J., Ong, Yong-Kwang Gene, Orkin, Aaron M., Paiva, Edison F., Parr, Michael J., Patocka, Catherine, Pellegrino, Jeffrey L., Perkins, Gavin D., Perlman, Jeffrey M., Rabi, Yacov, Reis, Amelia G., Reynolds, Joshua C., Ristagno, Giuseppe, Rodriguez-Nunez, Antonio, Roehr, Charles C., Rüdiger, Mario, Sakamoto, Tetsuya, Sandroni, Claudio, Sawyer, Taylor L., Schexnayder, Steve M., Schmölzer, Georg M., Schnaubelt, Sebastian, Semeraro, Federico, Skrifvars, Markus B., Smith, Christopher M., Sugiura, Takahiro, Tijssen, Janice A., Trevisanuto, Daniele, Van de Voorde, Patrick, Wang, Tzong-Luen, Weiner, Gary M., Wyllie, Jonathan P., Yang, Chih-Wei, Yeung, Joyce, Nolan, Jerry P., Berg, Katherine M., Burdick, Madeline C., Cartledge, Susie, Dawson, Jennifer A., Elgohary, Moustafa M., Ersdal, Hege L., Finan, Emer, Flaatten, Hilde I., Flores, Gustavo E., Fuerch, Janene, Garg, Rakesh, Gately, Callum, Goh, Mark, Halamek, Louis P., Handley, Anthony J., Hatanaka, Tetsuo, Hoover, Amber, Issa, Mohmoud, Johnson, Samantha, Kamlin, C. Omar, Ko, Ying-Chih, Kule, Amy, Leone, Tina A., MacKenzie, Ella, Macneil, Finlay, Montgomery, William, O’Dochartaigh, Domhnall, Ohshimo, Shinichiro, Palazzo, Francesco Stefano, Picard, Christopher, Quek, Bin Huey, Raitt, James, Ramaswamy, Viraraghavan V., Scapigliati, Andrea, Shah, Birju A., Stewart, Craig, Strand, Marya L., Szyld, Edgardo, Thio, Marta, Topjian, Alexis A., Udaeta, Enrique, Vaillancourt, Christian, Wetsch, Wolfgang A., Wigginton, Jane, Yamada, Nicole K., Yao, Sarah, Zace, Drieda, and Zelop, Carolyn M.

Published
2022
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50. Neonatal Health Care.

Author

Lee, Henry C. and Lee, Henry C.

Subjects
Humanities, Social interaction, California, NCPAP, NICU, biomedical technology, body temperature, clinical alarms, collaborative, collaborative quality improvement, debriefing, disaster preparedness, evacuation, health care costs, health service research, hyperthermia, hypothermia, in-situ simulation, infant, infants, intermittent hypoxia, nasal respiratory support, near-infrared spectroscopy, neonatal intensive care, neonatal intensive care unit, neonatal monitoring, neonatal resuscitation, neonatal simulation, neonates, neonatology, oxygenation, patient safety, perinatal care, perinatal healthcare, postnatal transition, preterm, quality, quality improvement, respiratory rate, s-NIPPV, simulation, statistics, study interpretation, term, tissue oxygenation, value, very low birthweight infant, video recording, wildfire
Abstract

Summary: This issue of Children concerns healthcare delivery and research in neonatology. Several articles concern the work of the California Perinatal Quality Care Collaborative, including a history by founder Dr. Jeffrey Gould, and recent quality improvement work. Other articles concern methodological issues in neonatal research and findings of recent clinical studies.

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