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Radiofrequency ablation (RFA) is a widely used minimally invasive technique for ablating solid tumors. Achieving precise personalized treatment necessitates feedback information on in situ thermal effects induced by the RFA procedure. While computer simulation facilitates the prediction of electrical and thermal phenomena associated with RFA, its practical implementation in clinical settings is hindered by high computational demands. In this paper, we propose a physics-guided neural network model, named PhysRFANet, to enable real-time prediction of thermal effect during RFA treatment. The networks, designed for predicting temperature distribution and the corresponding ablation lesion, were trained using biophysical computational models that integrated electrostatics, bio-heat transfer, and cell necrosis, alongside magnetic resonance (MR) images of breast cancer patients. Validation of the computational model was performed through experiments on ex vivo bovine liver tissue. Our model demonstrated a 96% Dice score in predicting the lesion volume and an RMSE of 0.4854 for temperature distribution when tested with foreseen tumor images. Notably, even with unforeseen images, it achieved a 93% Dice score for the ablation lesion and an RMSE of 0.6783 for temperature distribution. All networks were capable of inferring results within 10 ms. The presented technique, applied to optimize the placement of the electrode for a specific target region, holds significant promise in enhancing the safety and efficacy of RFA treatments.

There has been a significant increase from 2010 to 2016 in the number of people suffering from spine problems. The automatic image segmentation of the spine obtained from a computed tomography (CT) image is important for diagnosing spine conditions and for performing surgery with computer-assisted surgery systems. The spine has a complex anatomy that consists of 33 vertebrae, 23 intervertebral disks, the spinal cord, and connecting ribs. As a result, the spinal surgeon is faced with the challenge of needing a robust algorithm to segment and create a model of the spine. In this study, we developed an automatic segmentation method to segment the spine, and we compared our segmentation results with reference segmentations obtained by experts. We developed a fully automatic approach for spine segmentation from CT based on a hybrid method. This method combines the convolutional neural network (CNN) and fully convolutional network (FCN), and utilizes class redundancy as a soft constraint to greatly improve the segmentation results. The proposed method was found to significantly enhance the accuracy of the segmentation results and the system processing time. Our comparison was based on 12 measurements: the Dice coefficient (94%), Jaccard index (93%), volumetric similarity (96%), sensitivity (97%), specificity (99%), precision (over segmentation; 8.3 and under segmentation 2.6), accuracy (99%), Matthews correlation coefficient (0.93), mean surface distance (0.16 mm), Hausdorff distance (7.4 mm), and global consistency error (0.02). We experimented with CT images from 32 patients, and the experimental results demonstrated the efficiency of the proposed method., Comment: 18 pages, 5 figures, 3 tables