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14. Textbook outcome was associated with better survival in oral cancer surgery in southern Taiwan.

Author

Chiou, Ling‐Jan and Lee, Ching‐Chih

Subjects
*MOUTH tumors, *BODY mass index, *RESEARCH funding, *PATIENT readmissions, *HEMOGLOBINS, *TEXTBOOKS, *CANCER patients, *TREATMENT effectiveness, *MULTIVARIATE analysis, *DESCRIPTIVE statistics, *PLASTIC surgery, *LENGTH of stay in hospitals, *ALBUMINS, *CONFIDENCE intervals, *NECK surgery, *OVERALL survival
Abstract

Objective: To explore the impact of textbook outcome (TO) on long‐term survival in oral cancer surgery. Subjects and Methods: In total, 386 patients with tumor resection, neck dissection (ND), and reconstruction between 2011 and 2020 were included. TO was defined as negative margin; adequate ND; no 3‐day emergency room revisit; no 30‐day readmission; and length of stay ≤22 days. Multivariate Cox regression was used to evaluate the impact of TO and 5‐year overall survival (OS). Results: The TO rate was 35%. Younger age, subsite in buccal area, Charlson Comorbidity Index Score of 0, higher body mass index, higher hemoglobin, higher albumin, and unilateral ND were associated with TO. 5‐year OS was 70.5% in overall TO patients and 49.0% in non‐TO patients (HR, 0.47; 95% CI, 0.31–0.70; p < 0.001). Non‐TO was associated with an increased mortality rate (aHR, 1.73; 95% CI, 1.14–2.63) after adjusting other factors and the result remained robust with inverse probability of treatment weighting analysis. The impact of TO on OS was more significant in age <60, advanced stage, and diagnosis year before 2018. Conclusion: Not achieving TO in oral cancer surgery was associated with worse long‐term outcome. TO could be used as a proxy for surgical quality improvement. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Additional file 2 of Chemotherapy dose per kilogram lean body mass increased dose-limiting toxicity event in male head and neck cancer with taxane and platinum-based induction therapy

Author

Hung, Chuan-Jen, Kang, Bor-Hwang, Chang, Keng-Ming, Kang, Ying-Ying, Yin, Chun-Hao, and Lee, Ching-Chih

Abstract

Additional file 2: Supplementary Figure 1. Example of skeletal muscle measurements at the third cervical vertebral (C3) level on axial neck CT (A) and MRI (B) images. The paravertebral muscles are shown in green. The left sternocleidomastoid muscle is delineated in red, and the right sternocleidomastoid muscle in yellow.

Published
2022
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37. Additional file 1 of Chemotherapy dose per kilogram lean body mass increased dose-limiting toxicity event in male head and neck cancer with taxane and platinum-based induction therapy

Author

Hung, Chuan-Jen, Kang, Bor-Hwang, Chang, Keng-Ming, Kang, Ying-Ying, Yin, Chun-Hao, and Lee, Ching-Chih

Abstract

Additional file 1: Supplementary table 1. Intra-class correlation for different images at initial recruitment. Supplementary table 2. Variation of body composition factors and chemotherapy dose. Supplementary table 3. Cutoff points of chemotherapy per kilogram lean body mass for male and female head and neck patients. Supplementary table 4. Beta coefficient of independent predictors for DLT events in male head and neck cancer patients. Supplementary table 5. Demographic data of the validation cohort (n = 34). Supplementary table 6. Frequency of toxicity events after the first cycle of induction chemotherapy in the validation cohort (n = 34). Supplementary table 7. Toxicity event during the 1st cycle and response rate (n=125).

Published
2022
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