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842 results on '"Lee, Chih-Hao"'

1. Discovery and validation of plasma, saliva and multi-fluid plasma–saliva metabolomic scores predicting insulin resistance and diabetes progression or regression among Puerto Rican adults

Author

Haslam, Danielle E., Liang, Liming, Guo, Kai, Martínez-Lozano, Marijulie, Pérez, Cynthia M., Lee, Chih-Hao, Morou-Bermudez, Evangelia, Clish, Clary, Wong, David T. W., Manson, JoAnn E., Hu, Frank B., Stampfer, Meir J., Joshipura, Kaumudi, and Bhupathiraju, Shilpa N.

Published
2024
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2. Correction: Discovery and validation of plasma, saliva and multi-fluid plasma–saliva metabolomic scores predicting insulin resistance and diabetes progression or regression among Puerto Rican adults

Author

Haslam, Danielle E., Liang, Liming, Guo, Kai, Martínez-Lozano, Marijulie, Pérez, Cynthia M., Lee, Chih-Hao, Morou-Bermudez, Evangelia, Clish, Clary, Wong, David T. W., Manson, JoAnn E., Hu, Frank B., Stampfer, Meir J., Joshipura, Kaumudi, and Bhupathiraju, Shilpa N.

Published
2024
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8. Idealism, Professionalism and the Origins of the Workers' Educational Association: Revisiting the 'Oxford Report' of 1908

Author

Lee, Chih-Hao

Abstract

This paper uses the 1908 "Oxford Report," a founding document for the Workers' Educational Association, as a window onto the internal contradictions of the university adult education movement, an issue that has been neglected by historians of education. Examining the early history of the WEA shows that while the movement was inspired by Oxford Idealism and set itself the aim of democratising higher education, it also drew support from people who intended to professionalise the university by introducing the principles of trained expertise and selection by merit. The confluence of Idealism and professionalism resulted in a ground-breaking but inconsistent educational programme outlined in the "Oxford Report." This paper suggests that the attempt to simultaneously democratise and professionalise higher education was untenable and foreshadowed later tensions within the WEA movement.

Published
2021
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10. Exerkines in health, resilience and disease

Author

Chow, Lisa S., Gerszten, Robert E., Taylor, Joan M., Pedersen, Bente K., van Praag, Henriette, Trappe, Scott, Febbraio, Mark A., Galis, Zorina S., Gao, Yunling, Haus, Jacob M., Lanza, Ian R., Lavie, Carl J., Lee, Chih-Hao, Lucia, Alejandro, Moro, Cedric, Pandey, Ambarish, Robbins, Jeremy M., Stanford, Kristin I., Thackray, Alice E., Villeda, Saul, Watt, Matthew J., Xia, Ashley, Zierath, Juleen R., Goodpaster, Bret H., and Snyder, Michael P.

Published
2022
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11. The Workers' Educational Association and the pursuit of Oxford idealism, 1909-1949

Author

Lee, Chih-Hao and Biagini, Eugenio F.

Subjects
374, Idealism, Professionalism, Adult Education, Workers' Educational Association, Citizenship, Participatory Democracy, Education Reform
Abstract

This study examines the practical application of Oxford Idealism to education reform and the adult education movement. According to Idealist philosophy, enlightened and active citizenship was the cornerstone of a participatory democracy. This thesis thus explores how Oxford Idealists used the Workers' Educational Association (WEA) to pursue the aim of cultivating good citizenship and forming a common purpose for the future society they wished to see emerging. The WEA, founded in 1903, embodied the Idealist vision by promoting its two-fold practices: first, it organised university tutorial classes to foster mutual learning and fellowship between intellectuals and workers; second, it campaigned for a state-funded 'educational highway', from nursery to university, so that every citizen would have the opportunity to receive the kind of liberal education which had hitherto been limited to upper and middle classes. By exploring the development of the dual initiative, this thesis examines the achievement and limitations of the Idealist project. In particular, it investigates whether and how this pursuit, in the long run, contributed to the rise of professionalism, a trend which has been ascribed to the efforts of Idealists but which in many ways contradicted the ideal of participatory democracy. In so doing, this thesis explains why the influence of Oxford Idealism-this highly moralistic philosophy which inspired a generation of intellectuals and politicians and lent a distinctive flavour to British public policy at the beginning of the twentieth century-gradually ebbed in the public domain.

Published
2018
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15. Adsorption and dynamics of Si atoms at the monolayer Pb/Si(111) surface

Author

Kumar, Rakesh, Fang, Chuang-Kai, Lee, Chih-Hao, and Hwang, Ing-Shouh

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

In this work, we studied the adsorption behavior of deposited Si atoms along with their diffusion and other dynamic processes on a Pb monolayer-covered Si(111) surface from 125-230 K using a variable-temperature scanning tunneling microscope (STM). The Pb-covered Si(111) surface form a low-symmetry row-like structure in this temperature range and the Si atoms bind favorably to two specific on-top sites (T1A and T1B) on the trimer row after deposition at the sample temperature of 125 K. The Si atoms were immobile at low temperatures and started to switch between the two neighboring T1A and T1B sites within the same trimer when the temperature was raised to 150 K. When the temperature was raised above 160 K, the adsorbed Si atoms could hop to other trimers along the same trimer row. Below 170 K, short hops to adjacent trimers dominated, but long hops dominated at temperatures above 170 K. The activation energy and prefactor for the Si atoms diffusion were derived through analysis of continuous-time imaging at temperatures from 160-174 K. In addition, irreversible aggregation of single Si atoms into Si clusters started to occur at the phase boundaries or defective sites at temperatures above 170 K. This study provides crucial information for understanding the very initial stage of nucleation and growth behavior of epitaxial Si layers on a Pb-covered Si(111) surface. In addition, our study provides strong evidence for breaking in the mirror symmetry in the Pb-covered structure, which has implication for the atomic model of this controversial structure.

Published
2017
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17. Tricarboxylic acid cycle related-metabolites and risk of atrial fibrillation and heart failure

Author

Bulló, Mònica, Papandreou, Christopher, García-Gavilán, Jesus, Ruiz-Canela, Miguel, Li, Jun, Guasch-Ferré, Marta, Toledo, Estefanía, Clish, Clary, Corella, Dolores, Estruch, Ramon, Ros, Emilio, Fitó, Montserrat, Lee, Chih-Hao, Pierce, Kerry, Razquin, Cristina, Arós, Fernando, Serra-Majem, Lluís, Liang, Liming, Martínez-González, Miguel A., Hu, Frank B., and Salas-Salvadó, Jordi

Published
2021
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23. Reply to ‘Lactate as a major myokine and exerkine’

Author

Chow, Lisa S., Gerszten, Robert E., Taylor, Joan M., Pedersen, Bente K., van Praag, Henriette, Trappe, Scott, Febbraio, Mark A., Galis, Zorina S., Gao, Yunling, Haus, Jacob M., Lanza, Ian R., Lavie, Carl J., Lee, Chih-Hao, Lucia, Alejandro, Moro, Cedric, Pandey, Ambarish, Robbins, Jeremy M., Stanford, Kristin I., Thackray, Alice E., Villeda, Saul, Watt, Matthew J., Xia, Ashley, Zierath, Juleen R., Goodpaster, Bret H., and Snyder, Michael

Published
2022
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36. Nuclear receptor ERRα and coactivator PGC-1β are effectors of IFN-γ-induced host defense

Author

Sonoda, Junichiro, Laganière, Josée, Mehl, Isaac R, Barish, Grant D, Chong, Ling-Wa, Li, Xiangli, Scheffler, Immo E, Mock, Dennis C, Bataille, Alain R, Robert, François, Lee, Chih-Hao, Giguère, Vincent, and Evans, Ronald M

Subjects
Biochemistry and Cell Biology, Biological Sciences, Emerging Infectious Diseases, Genetics, Vaccine Related, Foodborne Illness, Infectious Diseases, Aetiology, 2.1 Biological and endogenous factors, Animals, Base Sequence, Carrier Proteins, DNA, Female, Gene Expression, In Vitro Techniques, Interferon-gamma, Listeria monocytogenes, Macrophage Activation, Macrophages, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Mitochondria, Models, Biological, RNA-Binding Proteins, Reactive Oxygen Species, Receptors, Estrogen, Recombinant Proteins, Signal Transduction, mitochondria, macrophages, oxidative metabolism, reactive oxygen species, Medical and Health Sciences, Psychology and Cognitive Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences, Psychology
Abstract

Macrophage activation by the proinflammatory cytokine interferon-gamma (IFN-gamma) is a critical component of the host innate response to bacterial pathogenesis. However, the precise nature of the IFN-gamma-induced activation pathway is not known. Here we show using genome-wide expression and chromatin-binding profiling that IFN-gamma induces the expression of many nuclear genes encoding mitochondrial respiratory chain machinery via activation of the nuclear receptor ERR alpha (estrogen-related receptor alpha, NR3B1). Studies with macrophages lacking ERR alpha demonstrate that it is required for induction of mitochondrial reactive oxygen species (ROS) production and efficient clearance of Listeria monocytogenes (LM) in response to IFN-gamma. As a result, mice lacking ERR alpha are susceptible to LM infection, a phenotype that is localized to bone marrow-derived cells. Furthermore, we found that IFN-gamma-induced activation of ERR alpha depends on coactivator PGC-1 beta (peroxisome proliferator-activated receptor gamma coactivator-1 beta), which appears to be a direct target for the IFN-gamma/STAT-1 signaling cascade. Thus, ERR alpha and PGC-1 beta act together as a key effector of IFN-gamma-induced mitochondrial ROS production and host defense.

Published
2007

37. Nuclear receptor ERR alpha and coactivator PGC-1 beta are effectors of IFN-gamma-induced host defense.

Author

Sonoda, Junichiro, Laganière, Josée, Mehl, Isaac R, Barish, Grant D, Chong, Ling-Wa, Li, Xiangli, Scheffler, Immo E, Mock, Dennis C, Bataille, Alain R, Robert, Francois, Lee, Chih-Hao, Giguère, Vincent, and Evans, Ronald M

Subjects
Mitochondria, Macrophages, Animals, Mice, Inbred C57BL, Mice, Knockout, Mice, Listeria monocytogenes, Reactive Oxygen Species, Carrier Proteins, Receptors, Estrogen, Recombinant Proteins, DNA, Signal Transduction, Macrophage Activation, Gene Expression, Base Sequence, Models, Biological, Female, Male, Interferon-gamma, In Vitro Techniques, RNA-Binding Proteins, mitochondria, macrophages, oxidative metabolism, reactive oxygen species, Inbred C57BL, Knockout, Receptors, Estrogen, Models, Biological, Developmental Biology, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences
Abstract

Macrophage activation by the proinflammatory cytokine interferon-gamma (IFN-gamma) is a critical component of the host innate response to bacterial pathogenesis. However, the precise nature of the IFN-gamma-induced activation pathway is not known. Here we show using genome-wide expression and chromatin-binding profiling that IFN-gamma induces the expression of many nuclear genes encoding mitochondrial respiratory chain machinery via activation of the nuclear receptor ERR alpha (estrogen-related receptor alpha, NR3B1). Studies with macrophages lacking ERR alpha demonstrate that it is required for induction of mitochondrial reactive oxygen species (ROS) production and efficient clearance of Listeria monocytogenes (LM) in response to IFN-gamma. As a result, mice lacking ERR alpha are susceptible to LM infection, a phenotype that is localized to bone marrow-derived cells. Furthermore, we found that IFN-gamma-induced activation of ERR alpha depends on coactivator PGC-1 beta (peroxisome proliferator-activated receptor gamma coactivator-1 beta), which appears to be a direct target for the IFN-gamma/STAT-1 signaling cascade. Thus, ERR alpha and PGC-1 beta act together as a key effector of IFN-gamma-induced mitochondrial ROS production and host defense.

Published
2007

41. Gamma-Ray Irradiation Induced Ultrahigh Room-Temperature Ferromagnetism in MoS2 Sputtered Few-Layered Thin Films

Author

Anbalagan, Aswin kumar, primary, Hu, Fang-Chi, additional, Chan, Weng Kent, additional, Gandhi, Ashish Chhaganlal, additional, Gupta, Shivam, additional, Chaudhary, Mayur, additional, Chuang, Kai-Wei, additional, Ramesh, Akhil K., additional, Billo, Tadesse, additional, Sabbah, Amr, additional, Chiang, Ching-Yu, additional, Tseng, Yuan-Chieh, additional, Chueh, Yu-Lun, additional, Wu, Sheng Yun, additional, Tai, Nyan-Hwa, additional, Chen, Hsin-Yi Tiffany, additional, and Lee, Chih-Hao, additional

Published
2023
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45. Emulating Neuromorphic and In‐Memory Computing Utilizing Defect Engineering in 2D‐Layered WSeOx and WSe2 Thin Films by Plasma‐Assisted Selenization Process.

Author

Chaudhary, Mayur, Yang, Tzu‐Yi, Chen, Chieh‐Ting, Lai, Po‐Chien, Hsu, Yu‐Chieh, Peng, Yu‐Ren, Kumar, Ashish, Lee, Chih‐Hao, and Chueh, Yu‐Lun

Subjects
CONVOLUTIONAL neural networks, THIN films, METAL fibers, IMAGE recognition (Computer vision), ENGINEERING
Abstract

The neuromorphic and in‐memory computing using memristors are promising for the building of the next generation computing systems. However, the diffusion dynamics of metal ions/atoms inside the switching medium impose variability in conducting filament (CF) formation, thus limiting their use in von‐Neumann architecture. The precise modulation on the diffusion of metal ions/atoms and their reduction/oxidation probability holds promise to overcome the speed, size, and energy issues of present‐day computers. Here, this study shows that the diffusion of metal ions can be modulated by defects inside the switching medium and confines metal filaments in a precise 1D channel. This filament confinement by the defect engineering leads to an anomalous switching mechanism with two interchangeable modes: unipolar threshold and bipolar modes. The variation between two modes can be modulated by controlling defects in the structures, leading to a uniform switching with low SET/RESET voltage variations of 17.3% and −17.6%, respectively. Moreover, the convolutional neural network is implemented to emulate synaptic plasticity and image recognition to achieve recognition accuracy of 87% due to a highly linear weight update, demonstrating its potential for in‐memory computing. [ABSTRACT FROM AUTHOR]

Published
2023
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