Search

Objective To summarize our experience in the diagnosis and treatment of malignant pancreatic endocrine tumour. Methods We retrospectively reviewed 36 cases of malignant pancreatic endocrine tumours in our hospital from July 1987 to April 2002, and summarized its clinical features. Results Liver metastasis was the main malignant manifestation of malignant pancreatic endocrine turnouts (incidence rate 72.2%). Removals of primary lesion and isolated hepatic metastatic lesion were means of curative therapy. Interventional chemotherapy was an important adjuvant treatment. Conclusion Comprehensive therapy plays an important role in improving the prognosis of malignant pancreatic endocrine tumour. [ABSTRACT FROM AUTHOR]

Here, we show that dBCAS2 (CG4980, human Breast Carcinoma Amplified Sequence 2 ortholog) is essential for the viability of Drosophila melanogaster. We find that ubiquitous or tissue-specific depletion of dBCAS2 leads to larval lethality, wing deformities, impaired splicing, and apoptosis. More importantly, overexpression of hBCAS2 rescues these defects. Furthermore, the C-terminal coiled-coil domain of hBCAS2 binds directly to CDC5L and recruits hPrp19/PLRG1 to form a core complex for splicing in mammalian cells and can partially restore wing damage induced by knocking down dBCAS2 in flies. In summary, Drosophila and human BCAS2 share a similar function in RNA splicing, which affects cell viability.

Objective: To evaluate the orthopedic effects of internal fixation of cervical pedicle screw on cervical spondylotic myelopathy with cervical kyphosis., Methods: Seventeen patients with cervical spondylotic myelopathy with cervical kyphosis with the Cobb's angle >10 degrees underwent internal fixation of cervical pedicle screw. The patients were followed up for 13. 8 months. The Cobb's angle of cervical kyphosis was measured before operation, one week after-operation, and upon the final follow up. The neural function and cervical spine stability were evaluated using Japanese Orthopedic Association (JOA) scoring system., Results: The average preoperative Cobb's angle of cervical kyphosis was -16.1 degrees before operation, was -3.3 degrees one week after operation, and was -3.8 degrees at the final follow-up. Follow-up 6 months after operation and at the final follow up showed that the fused segments were stable. The JOA score improved by 5.2 +/- 1.6 (P < 0.05) with a mean JOA score improvement rate of 64. 3%. No neurovascular and instrumentation-related complications occurred., Conclusion: Internal fixation of cervical pedicle screw is effective and safe in treatment of cervical spondylotic myelopathy with cervical kyphosis.