Search

Your search keyword '"Lee, Cha-Ze"' showing total 148 results
Start Over Author "Lee, Cha-Ze"
148 results on '"Lee, Cha-Ze"'

8. Characterization of integrative and conjugative element ICEKp1-associated genomic heterogeneity in a Klebsiella pneumoniae strain isolated from a primary liver abscess

Author

Lin, Tzu-Lung, Lee, Cha-Ze, Hsieh, Pei-Fang, Tsai, Shih-Feng, and Wang, Jin-Town

Subjects
Liver diseases -- Development and progression, Klebsiella -- Genetic aspects, Klebsiella -- Health aspects, Biological sciences
Abstract

Genomic heterogeneity has been shown to be associated with Klebsiella pneumoniae strains causing pyogenic liver abscesses (PLA) and metastatic infections. In order to explore the mechanism responsible for genomic heterogeneity in K. pneumoniae, we compared the complete genomic sequences of strains NTUH-K2044 and MGH78578. An -76-kbp DNA fragment located adjacent to an asparagine (asn) tRNA gene was present in NTUH-K2044 but not in MGH78578. This fragment could be divided into three regions with different functions, and structurally it resembled a functional integrative and conjugative element (ICE), ICEEc1, in Escherichia coli. The 5' region of this fragment contained genes similar to a high-pathogenicity island (HPI) of Yersinia pestis and Yersinia pseudotuberculosis. The middle region was similar to part of a large plasmid in K. pneumoniae, and the 3' region contained genes responsible for DNA conjugative transfer. Therefore, this DNA fragment was designated ICEKp1. Precise excision and extrachromosomal circularization of ICEKp1 were detected in K. pneumoniae wild-type strain NTUH-K2044. ICEKp1 could integrate into the asn tRNA loci of the chromosome of another K. pneumoniae isolate. The prevalence of ICEKp1 was higher in PLA strains (38 of 42 strains) than in non-tissue-invasive strains (5 of 32 strains). Therefore, ICEKp1 may contribute to the transmission of the HPI and result in K. pneumoniae PLA infection-associated genomic heterogeneity.

Published
2008

11. Virologic causes for DAA treatment failure of chronic hepatitis C

Author

Hong, Chun-Ming, primary, Liu, Chun-Jen, additional, Lin, You-Yu, additional, Yeh, Shiou-Hwei, additional, Yang, Hung-Chih, additional, Kao, Jia-Horng, additional, Liang, Ja-Der, additional, Chen, Chien-Hung, additional, Chen, Chieh-Chang, additional, Tsai, Feng-Chiao, additional, Huang, Guan-Tarn, additional, Hsu, Shih-Jer, additional, Yang, Pei-Ming, additional, Sheu, Jin-Chuan, additional, Hung, Chien-Ching, additional, Sun, Hsin-Yun, additional, Lee, Cha-Ze, additional, Liao, Sih-Han, additional, Huang, Yi-Hsiang, additional, Yang, Sheng-Shun, additional, Yu, Ming-Lung, additional, and Chen, Pei-Jer, additional

Published
2020
Full Text
View/download PDF

17. SAT391 - Virologic causes for DAA treatment failure of chronic hepatitis C

Author

Hong, Chun-Ming, Liu, Chun-Jen, Lin, You-Yu, Yeh, Shiou-Hwei, Yang, Hung-Chih, Kao, Jia-Horng, Liang, Ja-Der, Chen, Chien-Hung, Chen, Chieh-Chang, Tsai, Feng-Chiao, Huang, Guan-Tarn, Hsu, Shih-Jer, Yang, Pei-Ming, Sheu, Jin-Chuan, Hung, Chien-Ching, Sun, Hsin-Yun, Lee, Cha-Ze, Liao, Sih-Han, Huang, Yi-Hsiang, Yang, Sheng-Shun, Yu, Ming-Lung, and Chen, Pei-Jer

Published
2020
Full Text
View/download PDF

21. Negative Association of Proton Pump Inhibitors With Subsequent Development of Breast Cancer: A Nationwide Population‐Based Study.

Author

Chen, Chao‐Hung, Lee, Cha‐Ze, Lin, Yi‐Chun, Kao, Li‐Ting, and Lin, Herng‐Ching

Subjects
*BREAST tumor diagnosis, *BREAST tumor risk factors, *AGE distribution, *CONFIDENCE intervals, *DOSE-effect relationship in pharmacology, *MEDICAL prescriptions, *SCIENTIFIC observation, *COMORBIDITY, *PROTON pump inhibitors, *LOGISTIC regression analysis, *HEALTH insurance reimbursement, *SOCIOECONOMIC factors, *CASE-control method
Abstract

Although current evidence suggests potential antitumor activity of proton pump inhibitors (PPIs), there is no population‐based evidence of an association between PPI use and subsequent breast cancer risks. We used an observational case‐control study to examine the association between prior PPI use and breast cancer occurrence. Additional analysis examined dose‐response and age‐stratified associations of PPIs with breast cancer. This study used data from the Taiwan National Health Insurance Research Dataset. A total of 64,234 women diagnosed with breast cancer between 2004 and in 2013 were selected as cases. Controls were 64,234 women without cancer who were selected by matching them with cases on the basis of sociodemographic characteristics and widely prevalent comorbidities. Each study subject's claims data were tracked back for 5 years to determine precancer prescriptions of PPIs. Logistic regression modeling was used for the analysis. A total of 11,871 (9.24%) women had used PPIs within the prior 5 years, 8.06% and 10.42% among cases and controls, respectively. Breast cancer patients were 25% less likely to have had prior PPI exposure after adjustment for comorbidities that predispose to PPI exposure (95%CI 0.72‐0.78) in the risk of breast cancer occurrence. A dose‐response effect was also detected, with the highest effect, 35% lower PPI odds (95%CI 0.61‐0.70) among patients in the highest exposure category. Our findings may suggest that women at a higher‐than‐average risk of breast cancer may benefit from PPI prescriptions if they have medical conditions that could benefit from PPIs. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

50. Changes in Ploidy Distributions in Human Liver Carcinogenesis2.

Author

Saeter, Gunnar, Lee, Cha-Ze, Schwarze, Per K, Ous, Sigurd, Chen, Ding-Shinn, Sung, Juei-Low, and Seglen, Per O.

Abstract

Cellular and nuclear DNA content was measured by flow cytometry and the fraction of binudeated ceDs by fluorescence microscopy in normal adult human livers, bepatoceflular carcinomas, cirrbotic livers surrounding tumors, and in some benign liver conditions. In five normal livers about one-half of the hepatocytes were polyploid; the majority of these were binudeated te-traploids containing two diploid nuclei. Thus, potyploidiza-tion in human liver does not progress as far as, for example, in the rat, where 80%-90% of adult hepatocytes are polyploid, mostly with tetraploid or octoploid nuclei. In five human euplold hepatocellular carcinomas and one investigated case of focal nodular hyperplasia, the percentage of polyplold cells was significantly reduced.. Four other carcinomas exhibited a prominent aneuplold (hypotetraplold) peak in addition to the diplold peak. An abnormally low fraction of binucleated cells was also indicated in these tumors. Liver tissue surrounding the tumors had a ploldy distribution similar to that of normal liver. The results suggest that, like In several models of experimental hepatocardnogenesis, human bepatocellular tumor growth Is associated with a decreased polyploldization tendency and a corresponding increase in diploid, divisional growth, which may give the tumors a growth advantage relative to the surrounding liver. U Nati Cancer Inst 1988;8O.148O—1485] [ABSTRACT FROM PUBLISHER]

Published
1988

Catalog

Books, media, physical & digital resources
See catalog results