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The authors provide an overview of past and present trends in career guidance, career education, and vocational training in Hong Kong. Particular attention is given to evaluating career education policies and how these have evolved and affected practices in secondary schools over the past few decades. Topics also covered within the paper include students who drop out, mentor systems, teacher training, vocational training vs. university education, and parent involvement. Two representative case studies are used to illustrate successful programmes. The future development of career education and vocational training in Hong Kong is anticipated, and implications for school-based career counselling practices are considered.

We previously investigated the intracellular trafficking properties of our novel poly(l-glutamate)60-b-poly(l-leucine)20 (E60L20) vesicles (EL vesicles) conjugated to transferrin (Tf). In this study, we expand upon our previous work by investigating the drug encapsulation, release, and efficacy properties of our novel EL vesicles for the first time. After polyethylene glycol (PEG) was conjugated to the vesicles for steric stability, doxorubicin (DOX) was successfully encapsulated in the vesicles using a modified pH-ammonium sulfate gradient method. Tf was subsequently conjugated to the vesicles to provide active targeting to cancer cells and a mode of internalization into the cells. These Tf-conjugated, DOX-loaded, PEGylated EL (Tf-DPEL) vesicles exhibited colloidal stability and were within the allowable size range for passive and active targeting. A mathematical model was then derived to predict drug release from the Tf-DPEL vesicles by considering diffusive and convective mass transfer of DOX. Our mathematical model reasonably predicted our experimentally measured release profile with no fitted parameters, suggesting that the model could be used in the future to manipulate drug carrier properties to alter drug release profiles. Finally, an in vitro cytotoxicity assay was used to demonstrate that the Tf-DPEL vesicles exhibited enhanced drug carrier efficacy in comparison to its non-targeted counterpart.

The article presents a case study of a patient with schizophrenia who developed severe dysphagia as a result of antipsychotic medication. Topics include the patient's medical history, diagnostic evaluations, and the management of antipsychotic-induced dysphagia, including the switch to a different antipsychotic and dietary modifications.

What is shocking about the rape which precipitates the events of The Wife of Bath's Tale is the fact that it is apparently not expected to shock. It shocks not [...]

High-performance integrated electro-optic modulators operating at low temperature are critical for optical interconnects in cryogenic applications. Existing integrated modulators, however, suffer from reduced modulation efficiency or bandwidth at low temperatures because they rely on tuning mechanisms that degrade with decreasing temperature. Graphene modulators are a promising alternative because graphene's intrinsic carrier mobility increases at low temperature. Here, we demonstrate an integrated graphene-based electro-optic modulator whose 14.7 GHz bandwidth at 4.9 K exceeds the room temperature bandwidth of 12.6 GHz. The bandwidth of the modulator is limited only by high contact resistance, and its intrinsic RC-limited bandwidth is 200 GHz at 4.9 K. [ABSTRACT FROM AUTHOR]

This article provides a description of the current status of guidance and counseling in secondary schools in Hong Kong, and identifies some of the strengths and weaknesses in existing provisions. Brief attention is given to the way in which services and programs evolved and factors that have influenced their development. Particular attention is given to the concept of the "whole-school approach to guidance," and to the more recent "comprehensive guidance and counseling programs" in schools. Future directions in school counseling in Hong Kong are also considered. [ABSTRACT FROM AUTHOR]