Search

Your search keyword '"Lederle, Frank A."' showing total 546 results
Start Over Author "Lederle, Frank A."
546 results on '"Lederle, Frank A."'

1. Alcohol Consumption and Risk of Coronary Artery Disease (from the Million Veteran Program)

Author

Song, Rebecca J, Nguyen, Xuan-Mai T, Quaden, Rachel, Ho, Yuk-Lam, Justice, Amy C, Gagnon, David R, Cho, Kelly, O'Donnell, Christopher J, Concato, John, Gaziano, J Michael, Djoussé, Luc, Program, VA Million Veteran, Halasz, Ildiko, Federman, Daniel, Beckham, Jean, Sherman, Scott E, Sriram, Peruvemba, Tsao, Philip S, Boyko, Edward J, Xu, Junzhe, Lederle, Frank, Dellitalia, Louis J, McArdle, Rachel, Kaminsky, Laurence, Swann, Alan C, Hamner, Mark B, Florez, Hermes J, Pandya, Prashant, Villarreal, Gerardo, Wilson, Peter, Morgan, Timothy R, Davis, Lori, Hurley, Robin A, Meyer, Laurence, Ahuja, Sunil K, Konicki, Eric P, Cohen, David, Lichy, Jack, Whittle, Jeffrey, Haddock, Kathlyn Sue, Straub, Karl D, Callaghan, John T, Aguayo, Samuel M, Gupta, Samir, Washburn, Ronald G, Oehlert, Mary E, Hung, Adriana M, Wallbom, Agnes, Keith, Robert, Sonel, Elif, Schifman, Ronald B, Childress, Richard D, Godschalk, Michael F, Shuldiner, Alan R, Rastogi, Padmashri, Gutierrez, Salvador, Fernando, Ronald, Iruvanti, Pran R, Jhala, Darshana, Rosado-Rodriguez, Carlos, Mastorides, Stephen M, Harley, John B, Mattocks, Kristin, Robey, Brooks, Striker, Robert T, Rauchman, Michael, Wells, John, Ballas, Zuhair K, Woods, Susan S, Yeh, Shing Shing, Ratcliffe, Nora R, Klein, Jon B, Golden, Adam G, Ginzburg, Harold M, Sharma, Satish, Oursler, Kris Ann K, Whooley, Mary A, Gibson, Gretchen, and Heinz

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Substance Misuse, Brain Disorders, Heart Disease - Coronary Heart Disease, Alcoholism, Alcohol Use and Health, Heart Disease, Cardiovascular, Clinical Research, Atherosclerosis, Stroke, Oral and gastrointestinal, Good Health and Well Being, Aged, Alcohol Drinking, Alcoholic Beverages, Alcoholism, Coronary Artery Disease, Female, Humans, Male, Middle Aged, Proportional Hazards Models, Protective Factors, Risk Factors, Self Report, United States, Veterans, VA Million Veteran Program, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

Moderate alcohol consumption has been associated with a lower risk of coronary artery disease (CAD) in the general population but has not been well studied in US veterans. We obtained self-reported alcohol consumption from Million Veteran Program participants. Using electronic health records, CAD events were defined as 1 inpatient or 2 outpatient diagnosis codes for CAD, or 1 code for a coronary procedure. We excluded participants with prevalent CAD (n = 69,995) or incomplete alcohol information (n = 8,449). We used a Cox proportional hazards model to estimate hazard ratios and 95% confidence intervals for CAD, adjusting for age, gender, body mass index, race, smoking, education, and exercise. Among 156,728 participants, the mean age was 65.3 years (standard deviation = 12.1) and 91% were men. There were 6,153 CAD events during a mean follow-up of 2.9 years. Adjusted hazard ratios (95% confidence intervals) for CAD were 1.00 (reference), 1.02 (0.92 to 1.13), 0.83 (0.74 to 0.93), 0.77 (0.67 to 0.87), 0.71 (0.62 to 0.81), 0.62 (0.51 to 0.76), 0.58 (0.46 to 0.74), and 0.95 (0.85 to 1.06) for categories of never drinker; former drinker; current drinkers of ≤0.5 drink/day, >0.5 to 1 drink/day, >1 to 2 drinks/day, >2 to 3 drinks/day, and >3 to 4 drinks/day; and heavy drinkers (>4 drinks/day) or alcohol use disorder, respectively. For a fixed amount of ethanol, intake at ≥3 days/week was associated with lower CAD risk compared with ≤1 day/week. Beverage preference (beer, wine, or liquor) did not influence the alcohol-CAD relation. Our data show a lower risk of CAD with light-to-moderate alcohol consumption among US veterans, and drinking frequency may provide a further reduction in risk.

Published
2018

2. DASH Score and Subsequent Risk of Coronary Artery Disease: The Findings From Million Veteran Program

Author

Djoussé, Luc, Ho, Yuk‐Lam, Nguyen, Xuan‐Mai T, Gagnon, David R, Wilson, Peter WF, Cho, Kelly, Gaziano, J Michael, Program, the VA Million Veteran, Halasz, Ildiko, Federman, Daniel, Beckham, Jean, Sherman, Scott E, Sriram, Peruvemba, Tsao, Philip S, Boyko, Edward J, Xu, Junzhe, Lederle, Frank, Dellitalia, Louis J, McArdle, Rachel, Kaminsky, Laurence, Swann, Alan C, Hamner, Mark B, Florez, Hermes J, Pandya, Prashant, Villarreal, Gerardo, Wilson, Peter, Morgan, Timothy R, Davis, Lori, Hurley, Robin A, Meyer, Laurence, Ahuja, Sunil K, Konicki, Eric P, Cohen, David, Lichy, Jack, Whittle, Jeffrey, Haddock, Kathlyn Sue, Straub, Karl D, Callaghan, John T, Aguayo, Samuel M, Gupta, Samir, Washburn, Ronald G, Oehlert, Mary E, Hung, Adriana M, Wallbom, Agnes, Keith, Robert, Sonel, Elif, Schifman, Ronald B, Childress, Richard D, Godschalk, Michael F, Shuldiner, Alan R, Rastogi, Padmashri, Gutierrez, Salvador, Fernando, Ronald, Iruvanti, Pran R, Jhala, Darshana, Rosado‐Rodriguez, Carlos, Mastorides, Stephen M, Harley, John B, Mattocks, Kristin, Striker, Robert T, Rauchman, Michael, Wells, John, Ballas, Zuhair K, Woods, Susan S, Yeh, Shing, Ratcliffe, Nora R, Klein, Jon B, Golden, Adam G, Ginzburg, Harold M, Sharma, Satish, Oursler, Kris Ann K, Whooley, Mary A, and Gibson, Gretchen

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Nutrition, Hypertension, Atherosclerosis, Clinical Research, Cardiovascular, Prevention, Good Health and Well Being, Aged, Coronary Artery Disease, Diet, Healthy, Dietary Approaches To Stop Hypertension, Female, Humans, Incidence, Male, Middle Aged, Patient Compliance, Prognosis, Prospective Studies, Protective Factors, Risk Assessment, Risk Factors, Risk Reduction Behavior, Time Factors, United States, Veterans Health, VA Million Veteran Program, coronary artery disease, epidemiology, nutrition, Cardiorespiratory Medicine and Haematology, Cardiovascular medicine and haematology
Abstract

While adherence to healthful dietary patterns has been associated with a lower risk of coronary artery disease (CAD) in the general population, limited data are available among US veterans. We tested the hypothesis that adherence to Dietary Approach to Stop Hypertension (DASH) food pattern is associated with a lower risk of developing CAD among veterans. We analyzed data on 153 802 participants of the Million Veteran Program enrolled between 2011 and 2016. Information on dietary habits was obtained using a food frequency questionnaire at enrollment. We used electronic health records to assess the development of CAD during follow-up. Of the 153 802 veterans who provided information on diet and were free of CAD at baseline, the mean age was 64.0 (SD=11.8) years and 90.4% were men. During a mean follow-up of 2.8 years, 5451 CAD cases occurred. The crude incidence rate of CAD was 14.0, 13.1, 12.6, 12.3, and 11.1 cases per 1000 person-years across consecutive quintiles of Dietary Approach to Stop Hypertension score. Hazard ratios (95% confidence interval) for CAD were 1.0 (ref), 0.91 (0.84-0.99), 0.87 (0.80-0.95), 0.86 (0.79-0.94), and 0.80 (0.73-0.87) from the lowest to highest quintile of Dietary Approach to Stop Hypertension score controlling for age, sex, body mass index, race, smoking, exercise, alcohol intake, and statin use (P linear trend,

Published
2018

3. Alcohol Consumption and Risk of Coronary Artery Disease (from the Million Veteran Program)

Author

Halasz, Ildiko, Federman, Daniel, Beckham, Jean, Sherman, Scott E., Sriram, Peruvemba, Tsao, Philip S., Boyko, Edward J., Xu, Junzhe, Lederle, Frank, Dellitalia, Louis J., McArdle, Rachel, Kaminsky, Laurence, Swann, Alan C., Hamner, Mark B., Florez, Hermes J., Pandya, Prashant, Villarreal, Gerardo, Wilson, Peter, Morgan, Timothy R., Davis, Lori, Hurley, Robin A., Meyer, Laurence, Ahuja, Sunil K., Konicki, Eric P., Cohen, David, Lichy, Jack, Whittle, Jeffrey, Haddock, Kathlyn Sue, Straub, Karl D., Callaghan, John T., Aguayo, Samuel M., Gupta, Samir, Washburn, Ronald G., Oehlert, Mary E., Hung, Adriana M., Wallbom, Agnes, Keith, Robert, Sonel, Elif, Schifman, Ronald B., Childress, Richard D., Godschalk, Michael F., Shuldiner, Alan R., Rastogi, Padmashri, Gutierrez, Salvador, Fernando, Ronald, Iruvanti, Pran R., Jhala, Darshana, Rosado-Rodriguez, Carlos, Mastorides, Stephen M., Harley, John B., Mattocks, Kristin, Robey, Brooks, Striker, Robert T., Rauchman, Michael, Wells, John, Ballas, Zuhair K., Woods, Susan S., Yeh, Shing Shing, Ratcliffe, Nora R., Klein, Jon B., Golden, Adam G., Ginzburg, Harold M., Sharma, Satish, Oursler, Kris Ann K., Whooley, Mary A., Gibson, Gretchen, Heinz, Song, Rebecca J., Nguyen, Xuan-Mai T., Quaden, Rachel, Ho, Yuk-Lam, Justice, Amy C., Gagnon, David R., Cho, Kelly, O'Donnell, Christopher J., Concato, John, Gaziano, J. Michael, and Djoussé, Luc

Published
2018
Full Text
View/download PDF

18. Accuracy of teledermatology for pigmented neoplasms

Author

Warshaw, Erin M., Lederle, Frank A., Grill, Joseph P., Gravely, Amy A., Bangerter, Ann K., Fortier, Lawrence A., Bohjanen, Kimberly A., Chen, Karen, Lee, Peter K., Rabinovitz, Harold S., Johr, Robert H., Kaye, Valda N., Bowers, Sacharitha, Wenner, Rachel, Askari, Sharone K., Kedrowski, Deborah A., and Nelson, David B.

Published
2009
Full Text
View/download PDF

19. Accuracy of teledermatology for nonpigmented neoplasms

Author

Warshaw, Erin M., Lederle, Frank A., Grill, Joseph P., Gravely, Amy A., Bangerter, Ann K., Fortier, Lawrence A., Bohjanen, Kimberly A., Chen, Karen, Lee, Peter K., Rabinovitz, Harold S., Johr, Robert H., Kaye, Valda N., Bowers, Sacharitha, Wenner, Rachel, Askari, Sharone K., Kedrowski, Deborah A., and Nelson, David B.

Published
2009
Full Text
View/download PDF

24. Outcomes following endovascular vs open repair of abdominal aortic aneurysm

Author

Lederle, Frank A., Freischlag, Julie A., Kyriakides, Tassos C., Padberg, Frank T. Jr., Matsumura, Jon S., Kohler, Ted R., Lin, Peter H., Jean-Claude, Jessie M., Cikrit, Dolores F., Swanson, Kathleen M., and Peduzzi, Peter N.

Subjects
Abdominal aneurysm -- Care and treatment, Minimally invasive surgery -- Patient outcomes, Perioperative care -- Evaluation, Medical care -- Needs assessment, Needs assessment
Abstract

A study was conducted to evaluate and compare the outcomes in patients following endovascular or open repair of abdominal aortic aneurysm (AAA). Results indicated that perioperative mortality was found to be lower in the case of endovascular as compared to open repair of AAA.

Published
2009

26. The effect of ticagrelor on growth of small abdominal aortic aneurysms : a randomized controlled trial

Author

Wanhainen, Anders, Mani, Kevin, Kullberg, Joel, Svensjö, Sverker, Bersztel, Adam, Karlsson, Lars, Holst, Jan, Gottsäter, Anders, Linné, Anneli, Gillgren, Peter, Langenskiöld, Marcus, Hultgren, Rebecka, Roy, Joy, Gilgen, Nils-Peter, Ahlström, Håkan, Lederle, Frank A, Björck, Martin, Wanhainen, Anders, Mani, Kevin, Kullberg, Joel, Svensjö, Sverker, Bersztel, Adam, Karlsson, Lars, Holst, Jan, Gottsäter, Anders, Linné, Anneli, Gillgren, Peter, Langenskiöld, Marcus, Hultgren, Rebecka, Roy, Joy, Gilgen, Nils-Peter, Ahlström, Håkan, Lederle, Frank A, and Björck, Martin

Abstract

AIM: To evaluate if ticagrelor, an effective platelet inhibitor without known non-responders, could inhibit growth of small AAAs. METHODS AND RESULTS: In this multi-center randomized controlled trial, double-blinded for ticagrelor and placebo, acetylic salicylic acid naïve patients with AAA and with a maximum aortic diameter 35-49 mm were included. The primary outcome was mean reduction in log-transformed AAA volume growth rate (%) measured with magnetic resonance imaging (MRI) at 12 months compared with baseline. Secondary outcomes include AAA-diameter growth rate and ILT volume enlargement rate. 144 patients from eight Swedish centers were randomized (72 in each group). MRI AAA volume increase was 9.1% for the ticagrelor-group and 7.5% for the placebo-group (p = 0.205) based on intention-to-treat analysis, and 8.5% vs 7.4% in a per-protocol-analysis (p = 0.372). MRI diameter change was 2.5 mm vs 1.8 mm (p = 0.113), US diameter change 2.3 mm vs 2.2 mm (p = 0.778), and ILT volume change 12.9% vs 10.4% (p = 0.590). CONCLUSION: In this RCT platelet inhibition with ticagrelor did not reduce growth of small AAAs. Whether the ILT has an important pathophysiological role for AAA growth cannot be determined based on this study due to the observed lack of thrombus modulating effect of ticagrelor.

Published
2020
Full Text
View/download PDF

27. Costs of repair of abdominal aortic aneurysm with different devices in a multicenter randomized trial

Author

Matsumura, Jon S., Stroupe, Kevin T., Lederle, Frank A., Kyriakides, Tassos C., Ge, Ling, Freischlag, Julie A., Ketteler, Erika R., Kingsley, Darra D., Marek, John M., Massen, Richard J., Matteson, Brian D., Pitcher, David J., Langsfeld, Mark, Corson, John D., Goff, James M., Jr., Kasirajan, Karthnik, Paap, Christina, Robertson, Diane C., Salam, Atef, Veeraswamy, Ravi, Milner, Ross, Kasirajan, Karthikeshwar, Guidot, Jane, Lal, Brajesh K., Busuttil, Steven J., Lilly, Michael P., Braganza, Melita, Ellis, Kea, Patterson, Mark A., Jordan, William D., Whitley, David, Taylor, Steve, Passman, Marc, Kerns, Donna, Inman, Cindy, Poirier, Jennifer, Ebaugh, James, Raffetto, Joseph, Chew, David, Lathi, Subhash, Owens, Christopher, Hickson, Kathleen, Dosluoglu, Hasan H., Eschberger, Karen, Kibbe, Melina R., Baraniewski, Henry M., Matsumura, Jon, Endo, Michelle, Busman, Anna, Meadows, Wendy, Evans, Mary, Giglia, Joseph S., El Sayed, Hosam, Reed, Amy B., Ruf, Madeline, Ross, Stephanie, Jean-Claude, Jessie M., Pinault, Gilles, Kang, Preet, White, Nadine, Eiseman, Matthew, Jones, Reba, Timaran, Carlos H., Modrall, Gregory J., Welborn, Burress M., III, Lopez, Jorge, Nguyen, Tammy, Chacko, John K.Y., Granke, Kenneth, Vouyouka, Angela G., Olgren, Erin, Chand, Prakash, Allende, Brenda, Ranella, Michael, Yales, Claudia, Whitehill, Thomas A., Krupski, William C., Nehler, Mark R., Johnson, Stephen P., Jones, Darrell N., Strecker, Pamela, Bhola, Michelle A., Shortell, Cynthia K., Gray, John L., Lawson, Jeffrey H., McCann, Richard, Sebastian, Mark W., Tetterton, Jean Kistler, Blackwell, Carla, Prinzo, Patricia A., Lee, Nina, Padberg, Frank T., Jr., Cerveira, Joaquim J., Zickler, Robert W., Hauck, Karen A., Berceli, Scott A., Lee, Anthony W., Ozaki, Keith C., Nelson, Peter R., Irwin, Anne S., Baum, Randy, Aulivola, Bernadette, Rodriguez, Heron, Littooy, Fred N., Greisler, Howard, OʼSullivan, Mary T., Kougias, Panagiotis, Lin, Peter H., Bush, Ruth L., Guinn, Gene, Cagiannos, Catherine, Pillack, Sherilyn, Guillory, Barbara, Cikrit, Dolores, Lalka, Stephen G., Lemmon, Gary, Nachreiner, Ryan, Rusomaroff, Mitzi, OʼBrien, Elaine, Cullen, Joseph J., Hoballah, Jamal, Sharp, John W., McCandless, Jeanne L., Beach, Vickie, Minion, David, Schwarcz, Thomas H., Kimbrough, Joy, Ashe, Laura, Rockich, Anna, Warner-Carpenter, Jill, Moursi, Mohammed, Eidt, John F., Brock, Sandra, Bianchi, Christian, Bishop, Vicki, Gordon, Ian L., Fujitani, Roy, Kubaska, Stephen M., III, Behdad, Mina, Azadegan, Reza, Agas, Christine Ma, Zalecki, Kathy, Hoch, John R., Carr, Sandra C., Acher, Charles, Schwarze, Margaret, Tefera, Girma, Mell, Matthew, Dunlap, Beth, Rieder, Janice, Stuart, John M., Weiman, Darryl S., Abul-Khoudoud, Omran, Garrett, Edward H., Walsh, Sandra M., Wilson, Karen L., Seabrook, Gary R., Cambria, Robert A., Brown, Kellie R., Lewis, Brian D., Framberg, Susan, Kallio, Christa, Barke, Roderick A., Santilli, Steven M., dʼAudiffret, Alexandre C., Oberle, Nancy, Proebstle, Catherine, Lee Johnson, Lauri, Jacobowitz, Glenn R., Cayne, Neal, Rockman, Caron, Adelman, Mark, Gagne, Paul, Nalbandian, Matthew, Caropolo, Leah J., Pipinos, Iraklis I., Johanning, Jason, Lynch, Thomas, DeSpiegelaere, Holly, Purviance, Georgia, Zhou, Wei, Dalman, Ronald, Lee, Jason T., Safadi, Bassem, Coogan, Sheila M., Wren, Sherry M., Bahmani, Doghdoo D., Maples, Deanna, Thunen, Shawna, Golden, Michael A., Mitchell, Marc E., Fairman, Ronald, Reinhardt, Sally, Wilson, Mark A., Tzeng, Edith, Muluk, Satish, Peterson, Nina M., Foster, Maria, Edwards, James, Moneta, Gregory L., Landry, Gregory, Taylor, Lloyd, Yeager, Richard, Cannady, Eleanor, Treiman, Gerald, Hatton-Ward, Stephanie, Salabsky, Barbara, Owens, Erik, Forbes, Beth A., Rapp, Joseph H., Reilly, Linda M., Perez, Sandra L., Yan, Kimberly, Sarkar, Rajaabrata, Dwyer, Shelley S., Kohler, Ted R., Hatsukami, Thomas S., Glickerman, David G., Sobel, Michael, Burdick, Thomas S., Pedersen, Kimberly, Cleary, Patricia, Kansal, Nikhil, Estes, Melanie, Sobotta, Cinda, Back, Martin, Bandyk, Dennis, Johnson, Brad, Shames, Murray, Reinhard, Rebecca L., Thomas, Sandra C., Hunter, Glenn C., Leon, Luis R., Jr., Westerband, Alex, Guerra, Robert J., Riveros, Macario, Mills, John L., Sr., Hughes, John D., Escalante, Andrea M., Psalms, Shemuel B., Day, Nancy N., Macsata, Robyn, Sidawy, Anton, Weiswasser, Jonathan, Arora, Subodh, Jasper, Brenda J., Dardik, Alan, Gahtan, Vivian, Muhs, Bart E., Sumpio, Bauer E., Gusberg, Richard J., Spector, Marcelo, Pollak, Jeffrey, Aruny, John, Kelly, Lynne E., Wong, James, Vasilas, Penny, Joncas, Carmelene, Gelabert, Hugh A., DeVirgillio, Christian, Rigberg, David A., and Cole, Loretta

Published
2015
Full Text
View/download PDF

29. Response to Annweiler and Beauchet

Author

Rossom, Rebecca C., Espeland, Mark A., Manson, JoAnn E., Dysken, Maurice W., Johnson, Karen C., Lane, Dorothy S., LeBlanc, Erin S., Lederle, Frank A., Masaki, Kamal H., and Margolis, Karen L.

Published
2013
Full Text
View/download PDF

33. Contributors

Author

Baril, Donald T., primary, Barthel, Ginger, additional, Timothy Baxter, B., additional, Beard, Jonathan D., additional, Becquemin, Jean-Pierre, additional, Belkin, Michael, additional, Bower, Thomas C., additional, Burnand, Kevin G., additional, Buth, Jaap, additional, Byrne, John, additional, Cambria, Richard P., additional, Carsten, Christopher G., additional, Cherry, Kenneth J., additional, Clouse, W. Darrin, additional, Coggia, Marc, additional, Corriere, Matthew A., additional, Cull, David L., additional, Cuypers, Philippe, additional, Dake, Michael D., additional, Davies, Alun H., additional, Donaldson, Magruder C., additional, Dubois, Josée, additional, Durán, Walter N, additional, Earnshaw, Jonothan J., additional, Edwards, James M., additional, Edwards, Matthew S., additional, Freischlag, Julie, additional, Giswold, Mary E., additional, Gloviczki, Peter, additional, GoËau-Brissonnière, Olivier, additional, Gohel, Manj S., additional, Gray, Bruce H., additional, Guimaraes, Marcelo, additional, Hamish, Maher, additional, Hansen, Kimberley J., additional, Harden, Paul N., additional, Hendriks, Johanna M., additional, Hertzer, Norman R., additional, Huda, Walter, additional, Hunter, Glenn C., additional, Ihnat, Daniel M., additional, Kalish, Jeffrey A., additional, Kalra, Manju, additional, Kieffer, Edouard, additional, Kyriakides, Constantinos, additional, Lederle, Frank A., additional, Leon, Luis R., additional, Lindsey, Benjamin, additional, London, Nick J.M., additional, Mackey, William C., additional, MacTaggart, Jason, additional, Markovic, Jovan N., additional, McGuinness, Catharine L., additional, Meissner, Mark H., additional, Menard, Matthew T., additional, Miller, Virginia M., additional, Mills, Joseph L., additional, Moneta, Gregory L., additional, Moss, Jonathan G., additional, Naoum, Joseph J., additional, Naylor, A. Ross, additional, Oderich, Gustavo S., additional, O'Hara, Patrick J., additional, Oliva, Vincent L., additional, Padberg, Frank, additional, Pascarella, Luigi, additional, Pomposelli, Frank B., additional, Quinn, Brendon, additional, Rasmussen, Todd E., additional, Rectenwald, John E., additional, Reed, Amy B., additional, Reilly, Linda M., additional, Rhee, Robert Y., additional, Rhodes, Jeffrey M., additional, Ricotta, Joseph J., additional, Rigberg, David, additional, Schönholz, Claudio, additional, Sharma, Paritosh, additional, Shepherd, Amanda, additional, Shortell, Cynthia, additional, Smith, Frank C.T., additional, Soulez, Gilles, additional, Stanley, James C., additional, Tan, Kong Teng, additional, Teso, Desarom, additional, Textor, Stephen C., additional, Thompson, Brad H., additional, Uflacker, Renan, additional, Upchurch, Gilbert R., additional, van Beek, Edwin J.R., additional, van Sambeek, Marc R.H.M., additional, Vandy, Frank C., additional, Vorwerk, Dierk, additional, Wakefield, Thomas W., additional, Wheeler, Nicole, additional, White, John V., additional, Wixon, Christopher L., additional, Woodburn, Kenneth R., additional, and Woodside, Kenneth J., additional

Published
2009
Full Text
View/download PDF

35. Rupture rate of large abdominal aortic aneurysms in patients refusing or unfit for elective repair. (Original Contribution)

Author

Lederle, Frank A., Johnson, Gary R., Wilson, Samuel E., Ballard, David J., Jordan, William D., Jr., Blebea, John, Littooy, Fred N., Freischlag, Julie A., Bandyk, Dennis, Rapp, Joseph H., and Salam, Atef A.

Subjects
Aortic aneurysms -- Rupture, Dissecting aneurysm -- Risk factors
Abstract

About one-fourth of all abdominal aortic aneurysms that are larger than three inches in diameter will rupture within six months, according to a study of 198 patients. In this study, the larger the aneurysm was, the greater the risk of rupture. Aneurysms occur when an artery begins to expand because of an injury inside the artery., Context: Among patients with abdominal aortic aneurysm (AAA) who have high operative risk, repair is usually deferred until the AAA reaches a diameter at which rupture risk is thought to outweigh operative risk, but few data exist on rupture risk of large AAA. Objective: To determine the incidence of rupture in patients with large AAA. Design and Setting: Prospective cohort study in 47 Veterans Affairs medical centers. Patients: Veterans (n = 198) with AAA of at least 5.5 cm for whom elective AAA repair was not planned because of medical contraindication or patient refusal. Patients were enrolled between April 1995 and April 2000 and followed up through July 2000 (mean, 1.52 years). Main Outcome Measure: Incidence of AAA rupture by strata of initial and attained diameter. Results: Outcome ascertainment was complete for all patients. There were 112 deaths (57%) and the autopsy rate was 46%. Forty-five patients had probable AAA rupture. The 1-year incidence of probable rupture by initial AAA diameter was 9.4% for AAA of 5.5 to 5.9 cm, 10.2% for AAA of 6.0 to 6.9 cm (19.1 % for the subgroup of 6.5-6.9 cm), and 32.5% for AAA of 7.0 cm or more. Much of the increased risk of rupture associated with initial AAA diameters of 6.5-7.9 cm was related to the likelihood that the AAA diameter would reach 8.0 cm during follow-up, after which 25.7% ruptured within 6 months. Conclusion: The rupture rate is substantial in high-operative-risk patients with AAA of at least 5.5 cm in diameter and increases with larger diameter.

Published
2002

36. Immediate repair compared with surveillance of small abdominal aortic aneurysms

Author

Lederle, Frank A., Wilson, Samuel E., Johnson, Gary R., Reinke, Donovan B., Littooy, Fred N., Acher, Charles W., Ballard, David J., Messina, Louis M., Gordon, Ian L., Chute, Edmund P., Krupski, William C., and Bandyk, Dennis

Subjects
Aortic aneurysms, Abdominal aneurysm -- Prognosis
Abstract

People who have an abdominal aortic aneurysm that is less than two inches in diameter probably do not need surgery. An aneurysm is a weakness in an artery that makes it become wider. There is a chance that it will rupture, so surgery is done to prevent that. However, a study of over 1,000 patients found that most aneurysms that small will not rupture.

Published
2002

Catalog

Books, media, physical & digital resources
See catalog results