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2. Heart rate – a novel target for treatment of peripartum cardiomyopathy?

Author

Imamdin, Aqeela, Lecour, Sandrine, Opie, Lionel H., Sliwa, Karen, and Azibani, Feriel

Subjects
Heart rate, Peripartum cardiomyopathy, Pregnancy, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

During pregnancy, heart rate (HR) is physiologically elevated but recovery occurs within 4 weeks of delivery. Peripartum cardiomyopathy (PPCM) is an acute condition which manifests with symptoms of heart failure late during pregnancy, or within 6 months of delivery. One of its main symptoms is elevated HR. Current standard therapy for PPCM makes use of diuretics, ACE inhibitors and beta-blockers. This approach does not satisfactorily improve HR in patients, even after 6 months of treatment. Strong evidence from both experimental and clinical studies suggests that modulation of the sino-atrial node with drugs such as ivabradine may benefi t patients suffering from PPCM. The activity of ivabradine is likely two-fold – direct with regards to heart rate and indirect with long-term structural changes affecting the heart itself, as well as the vascular and endogenous physiological systems. Large clinical trials are needed to validate this concept and further exploration of this hypothesis in an established rodent model of PPCM is required to investigate the outcome on both HR and its effects on other observable systems affected by PPCM.

Published
2017
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4. Effect of Remote Ischaemic Conditioning on the Inflammatory Cytokine Cascade of COVID-19 (RIC in COVID-19): a Randomized Controlled Trial

Author

Lukhna, Kishal, do Carmo, Helison R. P., Castillo, Alejandro Rossell, Davidson, Sean M., Geffen, Hayli, Giesz, Sara, Golforoush, Pelin, Bovi, Ticiane Gonçalez, Gorag, Diana, Salama, Alan, Imamdin, Aqeela, Kalkhoran, Siavash, Lecour, Sandrine, Perroud Jr., Mauricio W., Ntsekhe, Mpiko, Sposito, Andrei C., and Yellon, Derek M.

Published
2024
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7. RIC in COVID-19—a Clinical Trial to Investigate Whether Remote Ischemic Conditioning (RIC) Can Prevent Deterioration to Critical Care in Patients with COVID-19

Author

Davidson, Sean M., Lukhna, Kishal, Gorog, Diana A., Salama, Alan D., Castillo, Alejandro Rosell, Giesz, Sara, Golforoush, Pelin, Kalkhoran, Siavash Beikoghli, Lecour, Sandrine, Imamdin, Aqeela, do Carmo, Helison R. P., Bovi, Ticiane Gonçalez, Perroud, Jr, Mauricio W., Ntsekhe, Mpiko, Sposito, Andrei C., and Yellon, Derek M.

Published
2022
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9. People living with HIV display increased anti-apolipoprotein A1 auto-antibodies, inflammation, and kynurenine metabolites: a case–control study

Author

Frias, Miguel A., primary, Pagano, Sabrina, additional, Bararpour, Nasim, additional, Sidibé, Jonathan, additional, Kamau, Festus, additional, Fétaud-Lapierre, Vanessa, additional, Hudson, Peter, additional, Thomas, Aurélien, additional, Lecour, Sandrine, additional, Strijdom, Hans, additional, and Vuilleumier, Nicolas, additional

Published
2024
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10. Correction to: RIC in COVID-19—a Clinical Trial to Investigate Whether Remote Ischemic Conditioning (RIC) Can Prevent Deterioration to Critical Care in Patients with COVID-19

Author

Davidson, Sean M., Lukhna, Kishal, Gorog, Diana A., Salama, Alan D., Castillo, Alejandro Rosell, Giesz, Sara, Golforoush, Pelin, Kalkhoran, Siavash Beikoghli, Lecour, Sandrine, Imamdin, Aqeela, do Carmo, Helison R. P., Bovi, Ticiane Gonçalez, Perroud, Jr, Mauricio W., Ntsekhe, Mpiko, Sposito, Andrei C., and Yellon, Derek M.

Published
2022
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20. Animal models and animal-free innovations for cardiovascular research

Author

van der Velden, Jolanda, Asselbergs, Folkert W, Bakkers, Jeroen, Batkai, Sandor, Bertrand, Luc, Bezzina, Connie R, Bot, Ilze, Brundel, Bianca, Carrier, Lucie, Chamuleau, Steven, Ciccarelli, Michele, Dawson, Dana, Davidson, Sean M, Dendorfer, Andreas, Duncker, Dirk J, Eschenhagen, Thomas, Fabritz, Larissa, Falcão-Pires, Ines, Ferdinandy, Péter, Giacca, Mauro, Girao, Henrique, Gollmann-Tepeköylü, Can, Gyongyosi, Mariann, Guzik, Tomasz J, Hamdani, Nazha, Heymans, Stephane, Hilfiker, Andres, Hilfiker-Kleiner, Denise, Hoekstra, Alfons G, Hulot, Jean-Sébastien, Kuster, Diederik W D, van Laake, Linda W, Lecour, Sandrine, Leiner, Tim, Linke, Wolfgang A, Lumens, Joost, Lutgens, Esther, Madonna, Rosalinda, Maegdefessel, Lars, Mayr, Manuel, van der Meer, Peter, Passier, Robert, Perbellini, Filippo, Perrino, Cinzia, Pesce, Maurizio, Priori, Silvia, Remme, Carol Ann, Rosenhahn, Bodo, Schotten, Ulrich, Sipido, Karin, Schulz, Rainer, Sluijter, Joost P G, van Steenbeek, Frank, Steffens, Sabine, Terracciano, Cesare M, Tocchetti, Carlo Gabriele, Vlasman, Patricia, Yeung, Kak Khee, Zacchigna, Serena, Zwaagman, Dayenne, Thum, Thomas, Interne geneeskunde GD, dCSCA AVR, CS_Genetics, Hubrecht Institute for Developmental Biology and Stem Cell Research, van der Velden, Jolanda, Asselbergs, Folkert W, Bakkers, Jeroen, Batkai, Sandor, Bertrand, Luc, Bezzina, Connie R, Bot, Ilze, Brundel, Bianca, Carrier, Lucie, Chamuleau, Steven, Ciccarelli, Michele, Dawson, Dana, Davidson, Sean M, Dendorfer, Andrea, Duncker, Dirk J, Eschenhagen, Thoma, Fabritz, Larissa, Falcão-Pires, Ine, Ferdinandy, Péter, Giacca, Mauro, Girao, Henrique, Gollmann-Tepeköylü, Can, Gyongyosi, Mariann, Guzik, Tomasz J, Hamdani, Nazha, Heymans, Stephane, Hilfiker, Andre, Hilfiker-Kleiner, Denise, Hoekstra, Alfons G, Hulot, Jean-Sébastien, Kuster, Diederik W D, van Laake, Linda W, Lecour, Sandrine, Leiner, Tim, Linke, Wolfgang A, Lumens, Joost, Lutgens, Esther, Madonna, Rosalinda, Maegdefessel, Lar, Mayr, Manuel, van der Meer, Peter, Passier, Robert, Perbellini, Filippo, Perrino, Cinzia, Pesce, Maurizio, Priori, Silvia, Remme, Carol Ann, Rosenhahn, Bodo, Schotten, Ulrich, Schulz, Rainer, Sipido, Karin, Sluijter, Joost P G, van Steenbeek, Frank, Steffens, Sabine, Terracciano, Cesare M, Tocchetti, Carlo Gabriele, Vlasman, Patricia, Yeung, Kak Khee, Zacchigna, Serena, Zwaagman, Dayenne, Thum, Thomas, Publica, Interne geneeskunde GD, dCSCA AVR, and CS_Genetics

Subjects
big data, bioinformatics, cardiovascular disease, co-morbidities, iPSC, multiomics, network medicine, tissue engineering, Physiology, Bioinformatics, multiomic, Review, Comorbidities, co-morbiditie, Big data, SDG 3 - Good Health and Well-being, Models, Physiology (medical), Humans, Animals, Tissue engineering, Cardiovascular Diseases/diagnosis, bioinformatic, Animal, Cardiovascular disease, Multiomics, Cardiovascular Diseases, Research Design, 2023 OA procedure, Models, Animal, Network medicine, Cardiology and Cardiovascular Medicine
Abstract

Cardiovascular diseases represent a major cause of morbidity and mortality, necessitating research to improve diagnostics, and to discover and test novel preventive and curative therapies. All of which warrant experimental models that recapitulate human disease. The translation of basic science results to clinical practice is a challenging task. In particular for complex conditions such as cardiovascular diseases, which often result from multiple risk factors and co-morbidities. This difficulty might lead some individuals to question the value of animal research, citing the translational 'valley of death', which largely reflects the fact that studies in rodents are difficult to translate to humans. This is also influenced by the fact that new, human-derived in vitro models can recapitulate aspects of disease processes. However, it would be a mistake to think that animal models cannot provide a vital step in the translational pathway as they do provide important pathophysiological insights into disease mechanisms particularly on a organ and systemic level. While stem cell-derived human models have the potential to become key in testing toxicity and effectiveness of new drugs, we need to be realistic, and carefully validate all new human-like disease models. In this position paper, we highlight recent advances in trying to reduce the number of animals for cardiovascular research ranging from stem cell-derived models to in situ modelling of heart properties, bioinformatic models based on large datasets, and improved current animal models, which show clinically relevant characteristics observed in patients with a cardiovascular disease. We aim to provide a guide to help researchers in their experimental design to translate bench findings to clinical routine taking the replacement, reduction and refinement (3R) as a guiding concept. [Abstract copyright: Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2022. For permissions please email: journals.permissions@oup.com.]

Published
2022
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23. Interaction of Cardiovascular Nonmodifiable Risk Factors, Comorbidities and Comedications With Ischemia/Reperfusion Injury and Cardioprotection by Pharmacological Treatments and Ischemic Conditioning

Author

Ferdinandy, Péter, primary, Andreadou, Ioanna, additional, Baxter, Gary F., additional, Bøtker, Hans Erik, additional, Davidson, Sean M., additional, Dobrev, Dobromir, additional, Gersh, Bernard J., additional, Heusch, Gerd, additional, Lecour, Sandrine, additional, Ruiz-Meana, Marisol, additional, Zuurbier, Coert J., additional, Hausenloy, Derek J., additional, and Schulz, Rainer, additional

Published
2022
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25. Effect of Remote Ischaemic Conditioning on the Inflammatory Cytokine Cascade of COVID-19 (RIC in COVID-19): a Randomized Controlled Trial

Author

Lukhna, Kishal, primary, do Carmo, Helison R. P., additional, Castillo, Alejandro Rossell, additional, Davidson, Sean M., additional, Geffen, Hayli, additional, Giesz, Sara, additional, Golforoush, Pelin, additional, Bovi, Ticiane Gonçalez, additional, Gorag, Diana, additional, Salama, Alan, additional, Imamdin, Aqeela, additional, Kalkhoran, Siavash, additional, Lecour, Sandrine, additional, Perroud, Mauricio W., additional, Ntsekhe, Mpiko, additional, Sposito, Andrei C., additional, and Yellon, Derek M., additional

Published
2022
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28. Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European Society of Cardiology

Author

Sluijter, Joost Petrus Gerardus, Davidson, Sean Michael, Boulanger, Chantal M, Buzás, Edit Iren, de Kleijn, Dominique Paschalis Victor, Engel, Felix Benedikt, Giricz, Zoltán, Hausenloy, Derek J, Kishore, Raj, Lecour, Sandrine, Leor, Jonathan, Madonna, Rosalinda, Perrino, Cinzia, Prunier, Fabrice, Sahoo, Susmita, Schiffelers, Ray Michel, Schulz, Rainer, Van Laake, Linda Wilhelmina, Ytrehus, Kirsti, and Ferdinandy, Péter

Published
2018
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30. The 10th Biennial Hatter Cardiovascular Institute workshop: cellular protection—evaluating new directions in the setting of myocardial infarction, ischaemic stroke, and cardio-oncology

Author

Davidson, Sean M., Arjun, Sapna, Basalay, Maryna V., Bell, Robert M., Bromage, Daniel I., Bøtker, Hans Erik, Carr, Richard D., Cunningham, John, Ghosh, Arjun K., Heusch, Gerd, Ibanez, Borja, Kleinbongard, Petra, Lecour, Sandrine, Maddock, Helen, Ovize, Michel, Walker, Malcolm, Wiart, Marlene, and Yellon, Derek M.

Published
2018
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37. Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC working group on myocardial function and the ESC Working Group on Cellular Biology of the Heart

Author

van der Velden, Jolanda, Asselbergs, Folkert W, Bakkers, Jeroen, Batkai, Sandor, Bertrand, Luc, Bezzina, Connie R, Bot, Ilze, Brundel, Bianca, Carrier, Lucie, Chamuleau, Steven, Ciccarelli, Michele, Dawson, Dana, Davidson, Sean M, Dendorfer, Andreas, Duncker, Dirk J, Eschenhagen, Thomas, Fabritz, Larissa, Falcão-Pires, Ines, Ferdinandy, Péter, Giacca, Mauro, Girao, Henrique, Gollmann-Tepeköylü, Can, Gyongyosi, Mariann, Guzik, Tomasz J, Hamdani, Nazha, Heymans, Stephane, Hilfiker, Andres, Hilfiker-Kleiner, Denise, Hoekstra, Alfons G, Hulot, Jean-Sébastien, Kuster, Diederik W D, van Laake, Linda W, Lecour, Sandrine, Leiner, Tim, Linke, Wolfgang A, Lumens, Joost, Lutgens, Esther, Madonna, Rosalinda, Maegdefessel, Lars, Mayr, Manuel, van der Meer, Peter, Passier, Robert, Perbellini, Filippo, Perrino, Cinzia, Pesce, Maurizio, Priori, Silvia, Remme, Carol Ann, Rosenhahn, Bodo, Schotten, Ulrich, Sipido, Karin, Schulz, Rainer, Sluijter, Joost P G, van Steenbeek, Frank, Steffens, Sabine, Terracciano, Cesare M, Tocchetti, Carlo Gabriele, Vlasman, Patricia, Yeung, Kak Khee, Zacchigna, Serena, Zwaagman, Dayenne, Thum, Thomas, van der Velden, Jolanda, Asselbergs, Folkert W, Bakkers, Jeroen, Batkai, Sandor, Bertrand, Luc, Bezzina, Connie R, Bot, Ilze, Brundel, Bianca, Carrier, Lucie, Chamuleau, Steven, Ciccarelli, Michele, Dawson, Dana, Davidson, Sean M, Dendorfer, Andreas, Duncker, Dirk J, Eschenhagen, Thomas, Fabritz, Larissa, Falcão-Pires, Ines, Ferdinandy, Péter, Giacca, Mauro, Girao, Henrique, Gollmann-Tepeköylü, Can, Gyongyosi, Mariann, Guzik, Tomasz J, Hamdani, Nazha, Heymans, Stephane, Hilfiker, Andres, Hilfiker-Kleiner, Denise, Hoekstra, Alfons G, Hulot, Jean-Sébastien, Kuster, Diederik W D, van Laake, Linda W, Lecour, Sandrine, Leiner, Tim, Linke, Wolfgang A, Lumens, Joost, Lutgens, Esther, Madonna, Rosalinda, Maegdefessel, Lars, Mayr, Manuel, van der Meer, Peter, Passier, Robert, Perbellini, Filippo, Perrino, Cinzia, Pesce, Maurizio, Priori, Silvia, Remme, Carol Ann, Rosenhahn, Bodo, Schotten, Ulrich, Sipido, Karin, Schulz, Rainer, Sluijter, Joost P G, van Steenbeek, Frank, Steffens, Sabine, Terracciano, Cesare M, Tocchetti, Carlo Gabriele, Vlasman, Patricia, Yeung, Kak Khee, Zacchigna, Serena, Zwaagman, Dayenne, and Thum, Thomas

Abstract

Cardiovascular diseases represent a major cause of morbidity and mortality, necessitating research to improve diagnostics, and to discover and test novel preventive and curative therapies, all of which warrant experimental models that recapitulate human disease. The translation of basic science results to clinical practice is a challenging task, in particular for complex conditions such as cardiovascular diseases, which often result from multiple risk factors and comorbidities. This difficulty might lead some individuals to question the value of animal research, citing the translational 'valley of death', which largely reflects the fact that studies in rodents are difficult to translate to humans. This is also influenced by the fact that new, human-derived in vitro models can recapitulate aspects of disease processes. However, it would be a mistake to think that animal models do not represent a vital step in the translational pathway as they do provide important pathophysiological insights into disease mechanisms particularly on an organ and systemic level. While stem cell-derived human models have the potential to become key in testing toxicity and effectiveness of new drugs, we need to be realistic, and carefully validate all new human-like disease models. In this position paper, we highlight recent advances in trying to reduce the number of animals for cardiovascular research ranging from stem cell-derived models to in situ modelling of heart properties, bioinformatic models based on large datasets, and state-of-the-art animal models, which show clinically relevant characteristics observed in patients with a cardiovascular disease. We aim to provide a guide to help researchers in their experimental design to translate bench findings to clinical routine taking the replacement, reduction, and refinement (3R) as a guiding concept.

Published
2022

38. Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC working group on myocardial function and the ESC Working Group on Cellular Biology of the Heart.

Author

UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, van der Velden, Jolanda, Asselbergs, Folkert W, Bakkers, Jeroen, Batkai, Sandor, Bertrand, Luc, Bezzina, Connie R, Bot, Ilze, Brundel, Bianca, Carrier, Lucie, Chamuleau, Steven, Ciccarelli, Michele, Dawson, Dana, Davidson, Sean M, Dendorfer, Andreas, Duncker, Dirk J, Eschenhagen, Thomas, Fabritz, Larissa, Falcão-Pires, Ines, Ferdinandy, Péter, Giacca, Mauro, Girao, Henrique, Gollmann-Tepeköylü, Can, Gyongyosi, Mariann, Guzik, Tomasz J, Hamdani, Nazha, Heymans, Stephane, Hilfiker, Andres, Hilfiker-Kleiner, Denise, Hoekstra, Alfons G, Hulot, Jean-Sébastien, Kuster, Diederik W D, van Laake, Linda W, Lecour, Sandrine, Leiner, Tim, Linke, Wolfgang A, Lumens, Joost, Lutgens, Esther, Madonna, Rosalinda, Maegdefessel, Lars, Mayr, Manuel, van der Meer, Peter, Passier, Robert, Perbellini, Filippo, Perrino, Cinzia, Pesce, Maurizio, Priori, Silvia, Remme, Carol Ann, Rosenhahn, Bodo, Schotten, Ulrich, Schulz, Rainer, Sipido, Karin, Sluijter, Joost P G, van Steenbeek, Frank, Steffens, Sabine, Terracciano, Cesare M, Tocchetti, Carlo Gabriele, Vlasman, Patricia, Yeung, Kak Khee, Zacchigna, Serena, Zwaagman, Dayenne, Thum, Thomas, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, van der Velden, Jolanda, Asselbergs, Folkert W, Bakkers, Jeroen, Batkai, Sandor, Bertrand, Luc, Bezzina, Connie R, Bot, Ilze, Brundel, Bianca, Carrier, Lucie, Chamuleau, Steven, Ciccarelli, Michele, Dawson, Dana, Davidson, Sean M, Dendorfer, Andreas, Duncker, Dirk J, Eschenhagen, Thomas, Fabritz, Larissa, Falcão-Pires, Ines, Ferdinandy, Péter, Giacca, Mauro, Girao, Henrique, Gollmann-Tepeköylü, Can, Gyongyosi, Mariann, Guzik, Tomasz J, Hamdani, Nazha, Heymans, Stephane, Hilfiker, Andres, Hilfiker-Kleiner, Denise, Hoekstra, Alfons G, Hulot, Jean-Sébastien, Kuster, Diederik W D, van Laake, Linda W, Lecour, Sandrine, Leiner, Tim, Linke, Wolfgang A, Lumens, Joost, Lutgens, Esther, Madonna, Rosalinda, Maegdefessel, Lars, Mayr, Manuel, van der Meer, Peter, Passier, Robert, Perbellini, Filippo, Perrino, Cinzia, Pesce, Maurizio, Priori, Silvia, Remme, Carol Ann, Rosenhahn, Bodo, Schotten, Ulrich, Schulz, Rainer, Sipido, Karin, Sluijter, Joost P G, van Steenbeek, Frank, Steffens, Sabine, Terracciano, Cesare M, Tocchetti, Carlo Gabriele, Vlasman, Patricia, Yeung, Kak Khee, Zacchigna, Serena, Zwaagman, Dayenne, and Thum, Thomas

Abstract

Cardiovascular diseases represent a major cause of morbidity and mortality, necessitating research to improve diagnostics, and to discover and test novel preventive and curative therapies. All of which warrant experimental models that recapitulate human disease. The translation of basic science results to clinical practice is a challenging task. In particular for complex conditions such as cardiovascular diseases, which often result from multiple risk factors and co-morbidities. This difficulty might lead some individuals to question the value of animal research, citing the translational 'valley of death', which largely reflects the fact that studies in rodents are difficult to translate to humans. This is also influenced by the fact that new, human-derived in vitro models can recapitulate aspects of disease processes. However, it would be a mistake to think that animal models cannot provide a vital step in the translational pathway as they do provide important pathophysiological insights into disease mechanisms particularly on a organ and systemic level. While stem cell-derived human models have the potential to become key in testing toxicity and effectiveness of new drugs, we need to be realistic, and carefully validate all new human-like disease models. In this position paper, we highlight recent advances in trying to reduce the number of animals for cardiovascular research ranging from stem cell-derived models to in situ modelling of heart properties, bioinformatic models based on large datasets, and improved current animal models, which show clinically relevant characteristics observed in patients with a cardiovascular disease. We aim to provide a guide to help researchers in their experimental design to translate bench findings to clinical routine taking the replacement, reduction and refinement (3R) as a guiding concept.

Published
2022

39. Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC working group on myocardial function and the ESC Working Group on Cellular Biology of the Heart

Author

Interne geneeskunde GD, dCSCA AVR, CS_Genetics, van der Velden, Jolanda, Asselbergs, Folkert W, Bakkers, Jeroen, Batkai, Sandor, Bertrand, Luc, Bezzina, Connie R, Bot, Ilze, Brundel, Bianca, Carrier, Lucie, Chamuleau, Steven, Ciccarelli, Michele, Dawson, Dana, Davidson, Sean M, Dendorfer, Andreas, Duncker, Dirk J, Eschenhagen, Thomas, Fabritz, Larissa, Falcão-Pires, Ines, Ferdinandy, Péter, Giacca, Mauro, Girao, Henrique, Gollmann-Tepeköylü, Can, Gyongyosi, Mariann, Guzik, Tomasz J, Hamdani, Nazha, Heymans, Stephane, Hilfiker, Andres, Hilfiker-Kleiner, Denise, Hoekstra, Alfons G, Hulot, Jean-Sébastien, Kuster, Diederik W D, van Laake, Linda W, Lecour, Sandrine, Leiner, Tim, Linke, Wolfgang A, Lumens, Joost, Lutgens, Esther, Madonna, Rosalinda, Maegdefessel, Lars, Mayr, Manuel, van der Meer, Peter, Passier, Robert, Perbellini, Filippo, Perrino, Cinzia, Pesce, Maurizio, Priori, Silvia, Remme, Carol Ann, Rosenhahn, Bodo, Schotten, Ulrich, Sipido, Karin, Schulz, Rainer, Sluijter, Joost P G, van Steenbeek, Frank, Steffens, Sabine, Terracciano, Cesare M, Tocchetti, Carlo Gabriele, Vlasman, Patricia, Yeung, Kak Khee, Zacchigna, Serena, Zwaagman, Dayenne, Thum, Thomas, Interne geneeskunde GD, dCSCA AVR, CS_Genetics, van der Velden, Jolanda, Asselbergs, Folkert W, Bakkers, Jeroen, Batkai, Sandor, Bertrand, Luc, Bezzina, Connie R, Bot, Ilze, Brundel, Bianca, Carrier, Lucie, Chamuleau, Steven, Ciccarelli, Michele, Dawson, Dana, Davidson, Sean M, Dendorfer, Andreas, Duncker, Dirk J, Eschenhagen, Thomas, Fabritz, Larissa, Falcão-Pires, Ines, Ferdinandy, Péter, Giacca, Mauro, Girao, Henrique, Gollmann-Tepeköylü, Can, Gyongyosi, Mariann, Guzik, Tomasz J, Hamdani, Nazha, Heymans, Stephane, Hilfiker, Andres, Hilfiker-Kleiner, Denise, Hoekstra, Alfons G, Hulot, Jean-Sébastien, Kuster, Diederik W D, van Laake, Linda W, Lecour, Sandrine, Leiner, Tim, Linke, Wolfgang A, Lumens, Joost, Lutgens, Esther, Madonna, Rosalinda, Maegdefessel, Lars, Mayr, Manuel, van der Meer, Peter, Passier, Robert, Perbellini, Filippo, Perrino, Cinzia, Pesce, Maurizio, Priori, Silvia, Remme, Carol Ann, Rosenhahn, Bodo, Schotten, Ulrich, Sipido, Karin, Schulz, Rainer, Sluijter, Joost P G, van Steenbeek, Frank, Steffens, Sabine, Terracciano, Cesare M, Tocchetti, Carlo Gabriele, Vlasman, Patricia, Yeung, Kak Khee, Zacchigna, Serena, Zwaagman, Dayenne, and Thum, Thomas

Published
2022

40. Redox Regulatory Changes of Circadian Rhythm by the Environmental Risk Factors Traffic Noise and Air Pollution

Author

Experimentele Afd. Cardiologie 2, Regenerative Medicine and Stem Cells, Team Medisch, Circulatory Health, Daiber, Andreas, Frenis, Katie, Kuntic, Marin, Li, Huige, Wolf, Eva, Kilgallen, Aoife B, Lecour, Sandrine, Van Laake, Linda W, Schulz, Rainer, Hahad, Omar, Münzel, Thomas, Experimentele Afd. Cardiologie 2, Regenerative Medicine and Stem Cells, Team Medisch, Circulatory Health, Daiber, Andreas, Frenis, Katie, Kuntic, Marin, Li, Huige, Wolf, Eva, Kilgallen, Aoife B, Lecour, Sandrine, Van Laake, Linda W, Schulz, Rainer, Hahad, Omar, and Münzel, Thomas

Published
2022

41. Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart

Author

Arts-assistenten Radiotherapie, Team Medisch, Circulatory Health, Cardiologie onderzoek 2, Onderzoek, Child Health, Regenerative Medicine and Stem Cells, MS Radiologie, Experimental Cardiology Laboratory, Onderzoek Cardiovasculair Reg. Med., Onderzoek Precision medicine, van der Velden, Jolanda, Asselbergs, Folkert W., Bakkers, Jeroen, Batkai, Sandor, Bertrand, Luc, Bezzina, Connie R., Bot, Ilze, Brundel, Bianca J.J.M., Carrier, Lucie, Chamuleau, Steven, Ciccarelli, Michele, Dawson, Dana, Davidson, Sean M., Dendorfer, Andreas, Duncker, Dirk J., Eschenhagen, Thomas, Fabritz, Larissa, Falcão-Pires, Ines, Ferdinandy, Péter, Giacca, Mauro, Girao, Henrique, Gollmann-Tepeköylü, Can, Gyongyosi, Mariann, Guzik, Tomasz J., Hamdani, Nazha, Heymans, Stephane, Hilfiker, Andres, Hilfiker-Kleiner, Denise, Hoekstra, Alfons G., Hulot, Jean Sébastien, Kuster, Diederik W.D., van Laake, Linda W., Lecour, Sandrine, Leiner, Tim, Linke, Wolfgang A., Lumens, Joost, Lutgens, Esther, Madonna, Rosalinda, Maegdefessel, Lars, Mayr, Manuel, van der Meer, Peter, Passier, Robert, Perbellini, Filippo, Perrino, Cinzia, Pesce, Maurizio, Priori, Silvia, Remme, Carol Ann, Rosenhahn, Bodo, Schotten, Ulrich, Schulz, Rainer, Sipido, Karin R., Sluijter, Joost P.G., van Steenbeek, Frank, Steffens, Sabine, Terracciano, Cesare M., Tocchetti, Carlo Gabriele, Vlasman, Patricia, Yeung, Kak Khee, Zacchigna, Serena, Zwaagman, Dayenne, Thum, Thomas, Arts-assistenten Radiotherapie, Team Medisch, Circulatory Health, Cardiologie onderzoek 2, Onderzoek, Child Health, Regenerative Medicine and Stem Cells, MS Radiologie, Experimental Cardiology Laboratory, Onderzoek Cardiovasculair Reg. Med., Onderzoek Precision medicine, van der Velden, Jolanda, Asselbergs, Folkert W., Bakkers, Jeroen, Batkai, Sandor, Bertrand, Luc, Bezzina, Connie R., Bot, Ilze, Brundel, Bianca J.J.M., Carrier, Lucie, Chamuleau, Steven, Ciccarelli, Michele, Dawson, Dana, Davidson, Sean M., Dendorfer, Andreas, Duncker, Dirk J., Eschenhagen, Thomas, Fabritz, Larissa, Falcão-Pires, Ines, Ferdinandy, Péter, Giacca, Mauro, Girao, Henrique, Gollmann-Tepeköylü, Can, Gyongyosi, Mariann, Guzik, Tomasz J., Hamdani, Nazha, Heymans, Stephane, Hilfiker, Andres, Hilfiker-Kleiner, Denise, Hoekstra, Alfons G., Hulot, Jean Sébastien, Kuster, Diederik W.D., van Laake, Linda W., Lecour, Sandrine, Leiner, Tim, Linke, Wolfgang A., Lumens, Joost, Lutgens, Esther, Madonna, Rosalinda, Maegdefessel, Lars, Mayr, Manuel, van der Meer, Peter, Passier, Robert, Perbellini, Filippo, Perrino, Cinzia, Pesce, Maurizio, Priori, Silvia, Remme, Carol Ann, Rosenhahn, Bodo, Schotten, Ulrich, Schulz, Rainer, Sipido, Karin R., Sluijter, Joost P.G., van Steenbeek, Frank, Steffens, Sabine, Terracciano, Cesare M., Tocchetti, Carlo Gabriele, Vlasman, Patricia, Yeung, Kak Khee, Zacchigna, Serena, Zwaagman, Dayenne, and Thum, Thomas

Published
2022

42. Circadian rhythms in ischaemic heart disease: key aspects for preclinical and translational research: position paper of the ESC working group on cellular biology of the heart

Author

Cardiologie, Onderzoek Cardiovasculair Reg. Med., Circulatory Health, Regenerative Medicine and Stem Cells, Team Medisch, Lecour, Sandrine, Du PrCrossed D Sign©, Bastiaan C., Bøtker, Hans Erik, Brundel, Bianca J.J.M., Daiber, Andreas, Davidson, Sean M., Ferdinandy, Peter, Girao, Henrique, Gollmann-Tepeköylü, Can, Gyöngyösi, Mariann, Hausenloy, Derek J., Madonna, Rosalinda, Marber, Michael, Perrino, Cinzia, Pesce, Maurizio, Schulz, Rainer, Sluijter, Joost P.G., Steffens, Sabine, Van Linthout, Sophie, Young, Martin E., Van Laake, Linda W., Cardiologie, Onderzoek Cardiovasculair Reg. Med., Circulatory Health, Regenerative Medicine and Stem Cells, Team Medisch, Lecour, Sandrine, Du PrCrossed D Sign©, Bastiaan C., Bøtker, Hans Erik, Brundel, Bianca J.J.M., Daiber, Andreas, Davidson, Sean M., Ferdinandy, Peter, Girao, Henrique, Gollmann-Tepeköylü, Can, Gyöngyösi, Mariann, Hausenloy, Derek J., Madonna, Rosalinda, Marber, Michael, Perrino, Cinzia, Pesce, Maurizio, Schulz, Rainer, Sluijter, Joost P.G., Steffens, Sabine, Van Linthout, Sophie, Young, Martin E., and Van Laake, Linda W.

Published
2022

43. Melatonin as a cardioprotective therapy following ST-segment elevation myocardial infarction: is it really promising? Reply

Author

Hausenloy, Derek J., Garcia-Dorado, David, Erik Bøtker, Hans, Davidson, Sean M., Downey, James, Engel, Felix B., Jennings, Robert, Lecour, Sandrine, Leor, Jonathan, Madonna, Rosalinda, Ovize, Michel, Perrino, Cinzia, Prunier, Fabrice, Schulz, Rainer, Sluijter, Joost P. G., Van Laake, Linda W., Vinten-Johansen, Jakob, Yellon, Derek M., Ytrehus, Kirsti, Heusch, Gerd, and Ferdinandy, Péter

Published
2017
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44. Epigenomic and transcriptomic approaches in the post-genomic era: path to novel targets for diagnosis and therapy of the ischaemic heart? Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart

Author

Perrino, Cinzia, Barabási, Albert-Laszló, Condorelli, Gianluigi, Davidson, Sean Michael, De Windt, Leon, Dimmeler, Stefanie, Engel, Felix Benedikt, Hausenloy, Derek John, Hill, Joseph Addison, Van Laake, Linda Wilhelmina, Lecour, Sandrine, Leor, Jonathan, Madonna, Rosalinda, Mayr, Manuel, Prunier, Fabrice, Sluijter, Joost Petrus Geradus, Schulz, Rainer, Thum, Thomas, Ytrehus, Kirsti, and Ferdinandy, Péter

Published
2017
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45. Novel targets and future strategies for acute cardioprotection: Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart

Author

Hausenloy, Derek J., Garcia-Dorado, David, Bøtker, Hans Erik, Davidson, Sean M., Downey, James, Engel, Felix B., Jennings, Robert, Lecour, Sandrine, Leor, Jonathan, Madonna, Rosalinda, Ovize, Michel, Perrino, Cinzia, Prunier, Fabrice, Schulz, Rainer, Sluijter, Joost P.G., Van Laake, Linda W., Vinten-Johansen, Jakob, Yellon, Derek M., Ytrehus, Kirsti, Heusch, Gerd, and Ferdinandy, Péter

Published
2017
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47. Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure

Author

Madonna, Rosalinda, Van Laake, Linda W., Davidson, Sean M., Engel, Felix B., Hausenloy, Derek J., Lecour, Sandrine, Leor, Jonathan, Perrino, Cinzia, Schulz, Rainer, Ytrehus, Kirsti, Landmesser, Ulf, Mummery, Christine L., Janssens, Stefan, Willerson, James, Eschenhagen, Thomas, Ferdinandy, Péter, and Sluijter, Joost P.G.

Published
2016
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50. Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery

Author

Hausenloy, Derek J., Barrabes, Jose A., Bøtker, Hans Erik, Davidson, Sean M., Di Lisa, Fabio, Downey, James, Engstrom, Thomas, Ferdinandy, Péter, Carbrera-Fuentes, Hector A., Heusch, Gerd, Ibanez, Borja, Iliodromitis, Efstathios K., Inserte, Javier, Jennings, Robert, Kalia, Neena, Kharbanda, Rajesh, Lecour, Sandrine, Marber, Michael, Miura, Tetsuji, Ovize, Michel, Perez-Pinzon, Miguel A., Piper, Hans Michael, Przyklenk, Karin, Schmidt, Michael Rahbek, Redington, Andrew, Ruiz-Meana, Marisol, Vilahur, Gemma, Vinten-Johansen, Jakob, Yellon, Derek M., and Garcia-Dorado, David

Published
2016
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