47 results on '"Leco, P A"'
Search Results
2. Plasma rich in growth factors (PRGF) and leukocyte-platelet rich fibrin (L-PRF): comparative release of growth factors and biological effect on osteoblasts
- Author
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Baca-Gonzalez, Laura, Serrano Zamora, Rebeca, Rancan, Lisa, González Fernández-Tresguerres, Francisco, Fernández-Tresguerres, Isabel, López-Pintor, Rosa M., López-Quiles, Juan, Leco, Isabel, and Torres, Jesús
- Published
- 2022
- Full Text
- View/download PDF
3. Management of Schneiderian membrane perforations during maxillary sinus floor augmentation with lateral approach in relation to subsequent implant survival rates: a systematic review and meta-analysis
- Author
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Díaz-Olivares, Luis Alfredo, Cortés-Bretón Brinkmann, Jorge, Martínez-Rodríguez, Natalia, Martínez-González, José María, López-Quiles, Juan, Leco-Berrocal, Isabel, and Meniz-García, Cristina
- Published
- 2021
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4. GPT-4 in a Cancer Center -- Institute-Wide Deployment Challenges and Lessons Learned.
- Author
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Umeton, Renato, Kwok, Anne, Maurya, Rahul, Leco, Domenic, Lenane, Naomi, Willcox, Jennifer, Abel, Gregory A., Tolikas, Mary, and Johnson, Jason M.
- Subjects
ARTIFICIAL intelligence ,LANGUAGE models ,MEDICAL records ,MEDICAL care ,CANCER - Abstract
The enormous potential for generative pretrained transformers (GPTs) and other artificial intelligence (AI) large language models (LLMs) to improve health care has become increasingly clear. Software tools based on LLMs have been shown to perform as well as or better than humans on many health care-related tasks, including generation of clinical documentation, extraction of structured data from medical records, performance on a growing number of medical board examination benchmarks, and writing accurate and empathetic responses to patients' medical questions. However, health care and cancer care settings pose unique ethical, legal, regulatory, and technical challenges for largescale deployment and adoption of LLMs. Such challenges include the essentiality of patient data privacy and security, the direct negative consequences of errors and biases, the need for model interpretability and supporting evidence, the necessity of safeguarding intellectual property and proprietary data, and the difficulty of modifying clinical and operational workflows. Consequently, few LLMs are in use in hospitals outside of controlled research studies or small pilot programs, and none to our knowledge is yet broadly deployed in a dedicated cancer center. In this case study, we report the challenges and lessons learned in the evaluation and deployment of LLMs at the Dana-Farber Cancer Institute for use in all business areas, including basic research, clinical research, and operations, but not in direct clinical care. In early discussions about whether and how to proceed, we realized that although some risks could be mitigated by clear policy guardrails and a secure technical environment, others would remain, including those regarding compliance with rapidly evolving regulations. We also recognized that substantial, ongoing work would be required to ensure appropriate ethical consideration of each use case and to ensure patient- and human-centric decision-making. After engaging in discussions over many months and employing a process framework for ethical implementation of AI in our cancer center, we believed it would be better to tackle these challenges as a community, rather than prohibit the use of LLMs altogether. Here, we detail aspects of sponsorship, governance, technical implementation, program launch, socialization, user feedback, and ongoing support and user training in preparation to make generative AI LLMs broadly available to our 12,500-member workforce in a compliant, auditable, and secure manner. We hope other institutions can benefit from our experience as they consider the deployment of these software tools to further their medical and research missions. [ABSTRACT FROM AUTHOR]
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- 2024
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- View/download PDF
5. An Evaluation of the Horizontal Research Elective at The University of Calgary
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Mandin, H., Woloschuk, W., Leco, P., Scherpbier, A. J. J. A., editor, van der Vleuten, C. P. M., editor, Rethans, J. J., editor, and van der Steeg, A. F. W., editor
- Published
- 1997
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- View/download PDF
6. Effectiveness of low-level diode laser in the management of complications after third-molar surgical extraction
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González, Fernanda Ferreira, Caponio, Vito Carlo Alberto, López Pintor, Rosa, Kemcha, Nardjesse, García-Denche, Jesús Torres, and Leco Berrocal, Isabel
- Abstract
The aim of this study was to evaluate the effects of low-level laser therapy (LLLT) in reducing postoperative pain, swelling, and trismus after extraction of third molars.
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- 2025
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- View/download PDF
7. Protocol for assessing mortality reduction with the early use of noninvasive ventilation in prehospital emergency services: A multicentre, observational cohort study in Madrid, Spain.
- Author
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Horrillo García, C., Cintora Sanz, A.M., Gutierrez Misis, A., Gómez-Morán Quintana, M., Torres Poza, A., Carrillo Fernández, O., Rendo Murillo, J.A., Perez Alonso, A.M., Pastor Cabanillas, L., Carrillo Fernández, A., Chaya Romero, C., García Oliva, R.C., Mazuecos Muñoz, D., Mir Montero, M., Leco Gil, N., Parejo García, L., Rubio Riballo, A.B., Canales Corcho, I., Barreiro Martínez, C., and Ibañez Concejo, A.T.
- Published
- 2022
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8. Cellular turnover and extracellular matrix remodeling in female reproductive tissues: functions of metalloproteinases and their inhibitors
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Fata, J. E., Ho, A. T.-V., Leco, K. J., Moorehead, R. A., and Khokha*, R.
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- 2000
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9. OsteoMac: A new player on the bone biology scene.
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Iglesias-Velazquez, Oscar, GF Tresguerres, Francisco, F. Tresguerres, Isabel, Leco-Berrocal, Isabel, Lopez-Pintor, Rosa, Baca, Laura, and Torres, Jesus
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BIOLOGY ,RHEUMATOID arthritis ,CLINICAL medicine ,PERIODONTAL disease ,DRUG target ,SYNTHETIC biology ,HOMEOSTASIS - Abstract
The knowledge of bone biology has undergone major advances in recent decades. In bone, resorbing osteoclasts have classically been described as tissue-resident macrophages, however, it is currently known that a new subtype of macrophages, called OsteoMacs, are specialised bone-resident macrophages, which, depending on certain conditions, may play an important role not only in bone homeostasis, but also in promoting pro-anabolic functions or in creating an inflammatory environment. There is growing evidence that these osteal macrophages may influence the development of bone-loss diseases. It is essential to understand the biological bases underlying bone physiological processes to search for new therapeutic targets for bone-loss diseases, such as osteoporosis, rheumatoid arthritis, or even periodontal disease. This narrative review provides an update on the origin, characterisation, and possible roles of osteoMacs in bone biology. Finally, the potential clinical applications of this new cell in bone-loss disorders are discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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- View/download PDF
10. The Relationship between the Migratory Experience in the United States and Criminal Activity in Mexico: A Qualitative Study.
- Author
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Ochoa, Jerjes Aguirre and Tomas, Casimiro Leco
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CRIME ,LAW enforcement ,DRUG traffic ,LAW enforcement agencies ,SOCIAL interaction - Abstract
Crime in Mexico is seen as the result of complex social processes in which migration -especially return migration-carries greater weight than it has traditionally been assigned. The dynamics of organized crime in the case of Michoacán, Mexico and, other parts of the country, have been significantly influenced by the migratory experience of criminal leaders in the USA, including the formation of social networks, the construction of transnational criminal nuclei, the visualization of market opportunities, the knowledge of the basic operation of justice and law enforcement systems in the United States, and understanding of the logistics of transporting goods to that country. This paper analyzes the migratory experience in the United States as a substantial social learning process of the formation of numerous criminal leaders in Mexico. [ABSTRACT FROM AUTHOR]
- Published
- 2018
11. Jaripeos Purépechas en Wendell, Carolina del Norte, Estados Unidos.
- Author
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Leco Tomás, Casimiro
- Published
- 2017
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12. Implant survival and complications in cases of inferior alveolar nerve lateralization and atrophied mandibles with 5-year follow-up.
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Martínez-Rodríguez, N., Barona-Dorado, C., Cortes-Breton Brinkmann, J., Martín-Ares, M., Leco-Berrocal, M.I., Prados-Frutos, J.C., Peñarrocha-Diago, M., and Martínez-González, J.M.
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ALVEOLAR nerve ,CORONECTOMY ,THERAPEUTICS ,MEDICAL care ,ATROPHIC gastritis - Abstract
The objectives of this study were to evaluate the survival after 5 years of implants placed using inferior alveolar nerve (IAN) lateralization in cases of mandibular atrophy and to determine the incidence of complications. Twenty-seven patients received 74 implants by means of the IAN lateralization technique. Implant survival after 5 years of loading was 98.6%. Eighteen months after surgery, the recovery of sensitivity was complete in 26 cases. Implant placement with IAN lateralization was seen to be a satisfactory and predictable technique. IAN lateralization requires a high level of technical skill, and strict criteria should be applied when prescribing this treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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- View/download PDF
13. P1.99. Outcomes from the implementation of daily jaw exercises to maintain jaw mobility for patients receiving head and neck radiotherapy
- Author
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Rose, T., primary, Leco, P., additional, and Wilson, J., additional
- Published
- 2009
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14. Periosteal Pocket Flap technique for lateral ridge augmentation. A comparative pilot study versus guide bone regeneration.
- Author
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Iglesias-Velázquez, Óscar, Zamora, Rebeca Serrano, López-Pintor, Rosa María, Tresguerres, Francisco G.F., Berrocal, Isabel Leco, García, Cristina Meniz, Tresguerres, Isabel Fernández, and García-Denche, Jesús Torres
- Subjects
GUIDED bone regeneration ,BONE regeneration ,ALVEOLAR process ,PLATELET-rich plasma ,PILOT projects ,BONE grafting ,POSTOPERATIVE pain - Abstract
Implant rehabilitation of posterior mandibular defects is frequently associated to a horizontal bone loss. There exist several regenerative techniques to supply this bone deficiency, one of which is the Periosteal Pocket Flap Technique (PPF) proposed by Steigmann et al. to treat small horizontal bone defects. The present study proposes a modification of this technique based on the concurrent use of PPF with the use of xenogeneic and autologous bone and Plasma Rich in Growth Factors (PRGF). The aim of this study is to evaluate clinical and radiographic outcomes of the PPF with the use of xenogeneic and autologous bone and PRGF in comparison with conventional Guided Bone Regeneration (GBR) procedures. Nine patients were enroled in the study (7 women and 2 men, mean age: 53 ± 2.74 years) and allocated to PPF or GBR. In both groups implant placement was performed simultaneously to bone regeneration. Preoperative CBCT scans were performed for each patient. Surgical time and postoperative pain were recorded, as well as tissue healing. Moreover, horizontal bone gain (mm), graft surface area (mm2) and graft volume (mm3) were evaluated. Nine surgeries were performed: 6 PPF and 3 GBR. Regarding clinical outcomes, operative time was significative greater in GBR group than in PPF group (51.67 ± 3.51 min vs. 37 ± 5.69 min; p = 0.008). Postoperative pain was higher in GBR compared to PPF (p = 0.011). Regarding radiographical results, there were not significant differences in horizontal bone gain (PPF: 9.43 ± 1.8 mm; GBR: 9.28 ± 0.42 mm), surface area (PPF: 693.33 ± 118.73 mm
2 ; GBR: 655.61 ± 102.43 mm2 ), and volume (PPF: 394.97 ± 178.72 mm3 ; GBR: 261.66 ± 118 mm3 ) between groups. This prospective study demonstrates that the combination of autograft/xenograft and PRGF in PPF technique is a simpler, cheaper, and faster technique than GBR technique for achieving moderate lateral bone augmentation in implant treatment. Future randomised clinical studies are needed to confirm the results. [ABSTRACT FROM AUTHOR]- Published
- 2022
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- View/download PDF
15. Expression of MMPs andTIMPs in Mammalian Cells.
- Author
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Walker, John M., Clark, Ian M., Yeow, Karen M.-L., Phillips, Blaine W., Beaudry, P. Paul, Leco, Kevin J., Murphy, Gillian, and Edwards, Dylan R.
- Abstract
Expression of recombinant matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in mammalian cells is an important step in their functional characterization. Also, transient transfection analysis of promoter constructs driving CAT or luciferase reporter genes is a mainstay of gene regulation studies. One of the critical advantages of mammalian expression over bacterial systems for production of functional proteins is that problems of refolding, which are particularly significant for the MMPs and TIMPs, are generally not encountered. Transient expression in COS cells is very rapid and can be useful in many situations, for instance to demonstrate activity or to compare the characteristics of mutant proteins. It can also generate sufficient quantities of protein for biochemical and cell biological studies, but most often bulk production will require stable expression. In this chapter we will discuss our experiences with transient expression in COS-1 and C3H 10T1/2 mouse fibroblasts, and describe two systems that we have used for constitutive stable expression, namely BHK (Baby Hamster Kidney) and the NS0 myeloma cell line. This chapter complements the information in Chapter 11 by Butler, d'Ortho, and Atkinson who have described stable, tetracycline-regulated expression of MT1-MMP in CHOL cells. Also, the reader should note that many expression vector systems are now available commercially, and we have not attempted here to provide comparisons. [ABSTRACT FROM AUTHOR]
- Published
- 2001
- Full Text
- View/download PDF
16. Relation between diagnosis of atheromatous plaque from orthopantomographs and cardiovascular risk factors. A study of cases and control subjects.
- Author
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Barona-Dorado, Cristina, Gutierrez-Bonet, Carmen, Leco-Berrocal, Isabel, Fernández-Cáliz, Fernando, and Martínez-González, José-María
- Subjects
ATHEROSCLEROTIC plaque ,PANORAMIC radiography ,CARDIOVASCULAR diseases risk factors ,DISEASE incidence ,MEDICAL radiography ,DIAGNOSIS - Abstract
Background: In recent years the use of orthopantomography has been proposed as a low-cost, reliable and noninvasive diagnostic medium for detecting atheromatous plaque. The purpose of this study was to correlate the presence of carotid calcifications (atheroma) in orthopantomographs with specific risk factors for cerebrovascular accidents (previous cerebrovascular accidents, arterial hypertension, and diabetes). Patient and Methods: The methods used in this observational study of cases and control subjects followed STROBE (Strengthening the Reporting of Observational studies in Epidemiology) recommendations. The study analyzed a total of 1,602 panoramic radiographs taken for dental diagnostic purposes between January 2010 and February 2014. The main variables analyzed were the incidence of atheromatous plaque and other cardiovascular risk factors. Epidat 3.1 statistical software was used to determine minimum sample sizes and the results were analyzed using PASW (Predictive Analytics Software) Statistics 10.0.0. Results: For all the variables analyzed, the correlation between radiographic detection of atheromatous plaque and the presence of cardiovascular disease risk factors was found to be statistically significant (RR>1.5). Conclusions: The presence of cardiovascular risk factors is related to the incidence of radiopaque lesions at the carotid artery bifurcation, indicating the presence of atheromatous plaque. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
17. La diáspora transnacional purépecha en Estados Unidos.
- Author
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Leco Tomás, Casimiro
- Subjects
DIASPORA ,INDIGENOUS peoples of Mexico ,HUMAN migrations ,COMMUNICATION ,ETHNICITY - Abstract
Copyright of Acta Universitaria is the property of Universidad de Guanajuato/Acta Universitaria and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2013
- Full Text
- View/download PDF
18. Rural Tourists and Their Attitudes and Motivations Towards the Practice of Environmental Activities such as Agrotourism.
- Author
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F., Leco, A., Pérez, J. M., Hernández, and A. M., Campón
- Abstract
Within the broader category of rural tourism, agrotourism is a type of tourism carried out in a very specific environment, mixed livestock and tillage farms. Its importance resides in the fact that it offers the possibility of complementing the income generated by the fami with income generated from tourism while at the same time carrying out an activity that promotes the conservation of nature. Although rural tourism has enjoyed strong growth in European countries such as Spain, the same has not occurred with agrotourism, in spite of the great potential that exists for it. The aim of this paper is to study the attitudes and motivations of tourists to the practice of agrotourism, an activity which has a strong environmental component. [ABSTRACT FROM AUTHOR]
- Published
- 2013
19. AGRICULTURAL DIVERSIFICATION AND THE SUSTAINABILITY OF AGRICULTURAL SYSTEMS: POSSIBILITIES FOR THE DEVELOPMENT OF AGROTOURISM??
- Author
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Hernández-Mogollón?, José-Manuel, Campón-Cerro, Ana-María, Leco-Berrocal, Felipe, and Pérez-Díaz, Antonio
- Abstract
Agrotourism, a form of tourism that falls within the framework of rural tourism, is based on the tourism taking place on farms with the possibility of doing work with the owners of the farm with this being seen as a leisure activity, educational in nature and of interest to members of many groups. The importance of this kind of tourism resides in the possibility of complementing the income generated from the farm with income produced by the tourism, as well as assuring the conservation of the environment and the agricultural system in which it takes place. The objective of this paper is to highlight the possibilities for the development of agrotourism in areas where it has had little impact, from the perspective of agricultural entrepreneurs and their willingness to diversify their traditional activities and make them compatible with tourism. A survey of 494 entrepreneurs carried out in Extremadura (Spain) shows the existence of a positive attitude to the development of tourism (80%), though these same entrepreneurs also show some reluctance to actually participate in it themselves. From this survey it can be seen that although this kind of tourism has great potential in the area with interesting benefits related to increasing the income and quality of life of the agricultural entrepreneur (74%), as well as the preservation of the landscape and rural heritage (71%), it still faces many challenges. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
20. The Development of Simple Daily Jaw Exercises for Patients Receiving Radical Head and Neck Radiotherapy.
- Author
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Rose, Tracey, Leco, Pamela, and Wilson, Jane
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EXERCISE ,HEALTH behavior ,JAWS ,FACIAL bones - Abstract
Copyright of Journal of Medical Imaging & Radiation Sciences is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2009
- Full Text
- View/download PDF
21. Nucleotide sequence of Escherichia coli katE, which encodes catalase HPII
- Author
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von Ossowski, I, primary, Mulvey, M R, additional, Leco, P A, additional, Borys, A, additional, and Loewen, P C, additional
- Published
- 1991
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- View/download PDF
22. Belt Damage Aspect to Impact Loading
- Author
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Ambriško, Ľubomír, Taraba, Vladimír, Szabo, Stanislav, and Leco, Martin
- Abstract
This paper presents the results of rubber products testing (rubber conveyor belt type P 2000/4, 8+4) with regard to their quality in order to establish the limit value of impact load, i.e. establish the maximum breakdown resistance. Outputs of measurements are in addition to the impact load also duration of impact, size of tension load and determination the effect of the support system for conveyor belts breakdown resistance. Using Design of Experiments method are identified factors that significantly affect the value of the impact load.
- Published
- 2014
- Full Text
- View/download PDF
23. Meta-análisis sobre la epidemiología y clínica de los odontomas.
- Author
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Hidalgo Sánchez, Olga, Isabel Leco Berrocal, Ma., and Ma. Martínez Gonzalez, José
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ODONTOGENIC tumors ,JAW tumors ,EPIDEMIOLOGY ,MAXILLA ,INCISORS ,X-rays - Abstract
Copyright of Medicina Oral, Patologia Oral y Cirugia Bucal is the property of Medicina Oral SL and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2008
24. Meta-análisis sobre materiales de obturación en cirugía periapical.
- Author
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Sanchez, Ángela Fernández Yáñez, Berrocal, M. Isabel Leco, and González, José M. Martínez
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META-analysis ,DENTAL fillings ,DENTAL amalgams ,GUIDED tissue regeneration ,BONES - Abstract
Copyright of Medicina Oral, Patologia Oral y Cirugia Bucal is the property of Medicina Oral SL and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2008
25. Demanda social en cirugía bucal ambulatoria. Casuística en el máster de Cirugía Bucal de la Universidad Complutense de Madrid.
- Author
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Isabel Leco Berrocal, María, María Martínez González, José, and Donado Rodríguez, Manuel
- Subjects
ORAL surgery ,QUANTITATIVE research ,MOLARS ,FEMALES ,ORAL surgeons - Abstract
Copyright of Medicina Oral, Patologia Oral y Cirugia Bucal is the property of Medicina Oral SL and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2008
26. Estudio observacional sobre la frecuencia de dientes supernumerarios en una población de 2000 pacientes.
- Author
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Isabel Leco Berrocal, Ma, F. Martín Morales, José, and M. Martínez González, José
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SUPERNUMERARY teeth ,DISEASE prevalence ,SCIENTIFIC observation ,DISEASE complications ,CYSTS (Pathology) - Abstract
Copyright of Medicina Oral, Patologia Oral y Cirugia Bucal is the property of Medicina Oral SL and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2007
27. Evolución clínica y radiográfica en apicectomías con láser de Erbium:YAG.
- Author
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Berrocal, Ma Isabel Leco, González, José Ma Martínez, and Rodríguez, Manuel Donado
- Subjects
APICOECTOMY ,ERBIUM ,OSSIFICATION ,IRRADIATION ,BICUSPIDS ,ENDODONTICS - Abstract
Copyright of Medicina Oral, Patologia Oral y Cirugia Bucal is the property of Medicina Oral SL and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2007
28. Efectos esterilizantes del láser Erbium:Yag sobre las estructuras dentarias: Estudio in vitro.
- Author
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Isabel Leco Berrocal, Ma., Ma. Martinez Gonzalez, José, Donado Rodriguez, Manuel, and Lopez Carriches, Carmen
- Subjects
STERILIZATION (Disinfection) ,BACTERIOLOGY technique ,ANAEROBIOSIS ,ECOLOGY ,METABOLISM - Abstract
Copyright of Medicina Oral, Patologia Oral y Cirugia Bucal is the property of Medicina Oral SL and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2006
29. Identification of an initiator-like element essential for the expression of the tissue inhibitor of metalloproteinases-4 (Timp-4) gene
- Author
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YOUNG, David A., PHILLIPS, Blaine W., LUNDY, Caroline, NUTTALL, Robert K., HOGAN, Aileen, SCHULTZ, Gilbert A., LECO, Kevin J., CLARK, Ian M., and EDWARDS, Dylan R.
- Abstract
We have used real-time quantitative reverse transcriptase PCR (TaqMan®) to quantify the expression of the four tissue inhibitor of metalloproteinases (Timp) genes in mouse tissues during development and in the adult. Among the four Timp genes, Timp-4 shows the most restricted pattern of expression, with highest RNA levels in brain, heart and testes. These data indicate that in the brain, Timp-4 transcripts are temporally regulated during development, becoming more abundant than those of the other Timps after birth. Cloning of the Timp-4 gene confirmed a five-exon organization resembling that of Timp-2 and Timp-3, and like all Timps, Timp-4 is located within an intron of a synapsin gene. Ribonuclease protection analysis and 5′-rapid amplification of cDNA ends PCR identified multiple transcription starts for Timp-4 from brain and heart mRNA. The promoter region of Timp-4 was functional in transient transfection analysis in mouse C3H10T1/2 fibroblasts, where it directed basal expression that was non-inducible by serum. The TATA-less promoter contains consensus motifs for Sp1 and an inverted CCAAT box upstream of an initiator-like element that is in close proximity to a transcription start site. Mutation of the CCAAT box caused a 2-fold increase in reporter expression. More significantly, mutation of the Sp1 motif or initiator-like element almost completely abolished reporter expression. This first functional characterization of the Timp-4 promoter shows it to be distinct from other members of the Timp family and provides insights into potential mechanisms controlling the tight spatio-temporal expression pattern of the gene.
- Published
- 2002
- Full Text
- View/download PDF
30. Matrix metalloproteinases mediate the dismantling of mesenchymal structures in the tadpole tail during thyroid hormone-induced tail resorption
- Author
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Jung, Jae-Chang, Leco, Kevin J., Edwards, Dylan R., and Fini, M. Elizabeth
- Abstract
It has been suggested that a family of tissue remodelling enzymes called matrix metalloproteinases (MMPs) play a causal role in the process of tail resorption during thyroid hormone-induced metamorphosis of the anuran tadpole; however, this hypothesis has never been directly substantiated. We cloned two new Xenopus MMPs, gelatinase A (MMP-2) and MT3-MMP (MMP-16), and the MMP inhibitor TIMP-2. These clones were used along with several others to perform a comprehensive expression study. We show that all MMPs and TIMP-2 are dramatically induced in the resorbing tail during spontaneous metamorphosis and are spatially coexpressed, primarily in the remodelling mesenchymal tissues. By Northern blotting, we show that all the examined MMPs/TIMP-2 are also induced by treatment of organ-cultured tails with thyroid hormone (T
3 ). Using the organ culture model, we provide the first direct evidence that MMPs are required for T3 -induced tail resorption by showing that a synthetic inhibitor of MMP activity/expression can specifically retard the resorption process. By gelatin zymography, we also show T3 induction of a fifth MMP, preliminarily identified as gelatinase B (GelB; MMP-9). Moreover, T3 not only induces MMP/TIMP expression but also MMP activation, and we provide evidence that TIMP-2 participates in the latter process. These findings suggest that MMPs and TIMPs act in concert to effect the dismantling of mesenchymal structures during T3 -induced metamorphic tadpole tail resorption. © 2002 Wiley-Liss, Inc.- Published
- 2002
- Full Text
- View/download PDF
31. Timp-1Is Important for Epithelial Proliferation and Branching Morphogenesis during Mouse Mammary Development
- Author
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Fata, Jimmie E., Leco, Kevin J., Moorehead, Roger A., Martin, David C., and Khokha, Rama
- Abstract
The dynamic process of mammary ductal morphogenesis depends on regulated epithelial proliferation and extracellular matrix (ECM) turnover. Epithelial cell–matrix contact closely dictates epithelial proliferation, differentiation, and survival. Despite the fact that tissue inhibitors of metalloproteinases (Timps) regulate ECM turnover, their function in mammary morphogenesis is unknown. We have delineated the spatiotemporal expression of all Timps(Timp-1to Timp-4) during discrete phases of murine mammary development. TimpmRNAs were abundant in mammary tissue, each displaying differential expression patterns with predominant localization in luminal epithelial cells. Timp-1mRNA was unique in that its expression was limited to the stage at which epithelial proliferation was high. To assess whether Timp-1 promotes or inhibits epithelial cell proliferation we manipulated mammary Timp-1 levels, genetically and biochemically. Down-regulation of epithelial-derived Timp-1in transgenic mice, by mouse mammary tumor virus promoter-directed Timp-1antisense RNA expression, led to augmented ductal expansion and increased number of ducts (P< 0.004). In these transgenics the integrity of basement membrane surrounding epithelial ducts, as visualized by laminin-specific immunostaining, was breached. In contrast to these mice, ductal expansion was markedly attenuated in the proximity of implanted recombinant Timp-1-releasing pellets (rTIMP-1), without an increase in basement membrane deposition around migrating terminal end buds. Epithelial proliferation and apoptosis were measured to determine the basis of altered ductal expansion. Luminal epithelial proliferation was increased by 55% (P< 0.02) in Timp-1-reduced transgenic mammary tissue and, conversely, decreased by 38% (P< 0.02) in terminal end buds by implanted rTIMP-1. Epithelial apoptosis was minimal and remained unaffected by Timp-1 manipulations. We conclude that Timps have an integral function in mammary morphogenesis and that Timp-1 regulates mammary epithelial proliferation in vivo,at least in part by maintaining basement membrane integrity.
- Published
- 1999
- Full Text
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32. A sequence-selective single-strand DNA-binding protein regulates basal transcription of the murine tissue inhibitor of metalloproteinases-1 (Timp-1) gene.
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Phillips, B W, Sharma, R, Leco, P A, and Edwards, D R
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Tissue inhibitor of metalloproteinases-1 (TIMP-1) is important in maintaining the extracellular proteolytic balance during tissue remodeling processes. To allow homeostatic tissue turnover, the murine Timp-1 gene is expressed by most cells at a low basal level, and during acute remodeling its transcription is activated by a variety of stimuli. A non-consensus AP-1-binding site (5'-TGAGTAA-3') that is conserved in mammalian timp-1 genes is a critical element in basal and serum-stimulated transcription. We show here that each strand of this unusual AP-1 site binds a distinct single-stranded DNA-binding protein, although neither strand from a perfect consensus AP-1 site from the human collagenase gene shows similar binding. One of the single-strand binding factors, which we term ssT1, binds to a second upstream Timp-1 region between nucleotides -115 and -100. Deletion analysis demonstrated that this region is important in basal but not serum-inducible transcription. The ssT1 factor was 52-54 kDa by UV cross-linking of electrophoretic mobility shift assays and Southwestern blot analysis. Its binding to DNA shows sequence selectivity rather than specificity, with 5'-CT/ATTN((4-6))ATC-3' as a favored motif. Multiple ssT1-like activities were found in nuclear extracts from mouse fibroblasts and rat liver and testis, suggesting that these factors may regulate basal Timp-1 transcription in a tissue-specific fashion.
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- 1999
33. Differential regulation of TIMP-1and TIMP-2mRNA expression in normal and Ha-ras-transformed murine fibroblasts
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Leco, Kevin J., Hayden, Lawrence J., Sharma, Renu R., Rocheleau, Hélène, Greenberg, Arnold H., and Edwards, Dylan R.
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A cDNA containing the complete coding region of the murine tissue inhibitor of metalloproteinases-2 (TIMP-2) was isolated using reverse transcription-polymerase chain reaction amplification . The predicted murine TIMP-2 amino acid sequence shows 96% identity with human TIMP-2, but only 42% identity with murine TIMP-1. This high degree of evolutionary conservation between the human and mouse proteins suggests that TIMP-2 performs an essential biological function. The expression of the TIMP-1and TIMP-2mRNAs was examined in normal and ras-transformed murine fibroblasts. While TIMP-1transcription was highly serum-inducible in normal murine C3H10T1/2 fibroblasts, TIMP-2mRNA expression was largely constitutive. A series of ras-transformed derivatives of C3H10T1/2 fibroblasts showed great variability in TIMP-1expression: some lines retained serum indicibility, others displayed constitutive expression at either high or low levels. In contrast, TIMP-2expression was insensitive to transformation. Neither TIMP-1nor TIMP-2expression at the RNA level, or total TIMP activity in conditioned media could be correlated with the metastatic potential of the ras-transformed lines. Our data demonstrate that the mechanisms that regulate murine TIMP-1and TIMP-2expression are distinct arguing for different physiological roles for the two TIMPs.
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- 1992
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34. The apolipoprotein E4 allele is not associated with an abnormal lipid profile in a Native American population following its traditional lifestyle
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Aguilar, C. A., Talavera, G., Ordovas, J. M., Barriguete, J. A., Guillen, L. E., Leco, M. E., Pedro-Botet, J., Gonzalez-Barranco, J., Gomez-Perez, F. J., and Rull, J. A.
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- 1999
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35. Roles of growth factors during peri-implantation development.
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Harvey, M B, Leco, K J, Arcellana-Panlilio, M Y, Zhang, X, Edwards, D R, and Schultz, G A
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Several growth factor ligand and receptor gene products have been shown to play roles during preimplantation mammalian development. Genes for insulin-like growth factors (IGFs), transforming growth factors (TGFs), fibroblast growth factor (FGF), platelet-derived growth factor (PDGF) and receptors for insulin, IGF, PDGF, TGF alpha and epidermal growth factor (EGF) are expressed by early embryos of several species including mouse, rat, cow and sheep. Roles of growth factors during early development have been demonstrated by addition of purified growth factors to culture medium or by molecular genetic techniques that interfere with gene expression. In this way, it has been shown that successful development of the blastocyst is dependent on the action of epidermal growth factor (EGF) and leukaemia inhibitory factor (LIF). Recent experiments show that both LIF and EGF stimulate secretion of urokinase-type plasminogen activator (uPA) and gelatinase B/matrix metalloproteinase-9 (MMP-9) in day 7 mouse blastocyst outgrowths. At the same time, tissue inhibitors of MMPs (TIMPs) are also expressed by embryonic, decidual and uterine tissues during the implantation process. It appears that LIF may act directly or indirectly, by inducing the expression of other cytokines, to regulate the temporal and spatial production and activity of proteases and protease inhibitors to create a favourable environment for implantation.
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- 1995
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36. Cloning of the Human Tissue Inhibitor of Metalloproteinase-4 Gene (TIMP4) and Localization of the TIMP4 andTimp4Genes to Human Chromosome 3p25 and Mouse Chromosome 6, Respectively
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Olson, Timothy M., Hirohata, Satoshi, Ye, Jean, Leco, Kevin, Seldin, Michael F., and Apte, Suneel S.
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We have isolated genomic DNA containing the human tissue inhibitor of metalloproteinases-4 gene (TIMP4) and determined the structure of the exons comprising the gene. Like other members of the TIMP family, the TIMP-4 protein is encoded by five exons. These span 6 kb of genomic DNA, so that TIMP4 is similar in size toTimp1but considerably smaller than TIMP2 and TIMP3. The exon–intron boundaries of TIMP4 are at locations very similar to those of the other TIMP genes, demonstrating the high degree of conservation of gene structure in this family. The human and mouse TIMP-4 genes map to comparable locations in the respective genomes, localizing to human chromosome 3p25 and mouse chromosome 6.
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- 1998
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37. Expression of metalloproteinases and their inhibitors in primary pulmonary carcinomas
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Urbanski, SJ, Edwards, DR, Maitland, A, Leco, KJ, Watson, A, and Kossakowska, AE
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Nine primary pulmonary carcinomas, one metastatic carcinoma, and two malignant pleural mesotheliomas have been analysed for the expression at the mRNA level of metalloproteinases (MPs) and tissue inhibitors of MPs (TIMPs). In situ hybridisation showed TIMP-1 and TIMP-2 transcripts predominantly over tumour stroma and gelatinases evenly distributed over both stromal and tumour cells. While both TIMP-1 and TIMP-2 were expressed in non-neoplastic lungs (NNL) as well as in carcinomas, stromelysin 3 (ST3), 92 kDa gelatinase and interstitial collagenase were expressed only by carcinomas. Expression of these MPs by carcinomas was independent of histologic type and such tumour features as fibrosis or necrosis. The consistent expression of ST3 by all of the carcinomas examined and absence of its expression in NNL indicates that ST3 production is likely associated with the malignant phenotype. However, since 92 kDa gelatinase and interstitial collagenase transcripts were found in some but not all tumour samples, their expression is not a uniform feature of pulmonary carcinomas. The possible prognostic significance of the expression of the latter two enzymes by carcinomas remains to be established.
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- 1992
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38. Murine tissue inhibitor of metalloproteinases—4 (Timp—4): cDNA isolation and expression in adult mouse tissues 1
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Leco, Kevin J., Apte, Suneel S., Taniguchi, Gary T., Hawkes, Susan P., Khokha, Rama, Schultz, Gilbert A., and Edwards, Dylan R.
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We have isolated cDNA clones corresponding to a new member of the murine tissue inhibitor of metalloproteinase (TIMP) family, designated Timp‐4. The nucleotide sequence predicts a protein of 22 609 Da that contains the characteristic 12 cysteine TIMP signature. TIMP‐4 is more closely related to TIMP‐2 and TIMP‐3 than to TIMP‐1 (48%, 45% and 38% identity, respectively). Analysis of Timp‐4 mRNA expression in adult mouse tissues indicated a 1.2 kb transcript in brain, heart, ovary and skeletal muscle. This pattern of expression distinguishes Timp‐4 from other Timps, suggesting that the TIMP‐4 protein may be an important tissue‐specific regulator of extracellular matrix remodelling.
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- 1997
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39. Proteinase expression in early mouse embryos is regulated by leukaemia inhibitory factor and epidermal growth factor.
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Harvey, M B, Leco, K J, Arcellana-Panlilio, M Y, Zhang, X, Edwards, D R, and Schultz, G A
- Abstract
Several proteinases from different multigene families have been implicated in the uterine invasion required for establishment of pregnancy in some mammals. In this study, the expression of matrix metalloproteinase gelatinase B (MMP-9), urokinase-type plasminogen activator (uPA) and their inhibitors was investigated during early mouse embryo development. Transcripts for tissue inhibitors of metalloproteinases (TIMP-1,-2,-3) and uPA receptor were detected throughout pre- and peri-implantation development whilst MMP-9 and uPA mRNAs were first detected in peri-implantation blastocysts associated with the invasive phase of implantation. Through use of in situ hybridization, it was shown that MMP-9 transcripts were strongly expressed in the network of trophoblast giant cells at the periphery of implanting 7.5 day embryos and TIMP-3 transcripts were strongly expressed in the decidua immediately adjacent to the implanting embryo. uPA transcripts were preferentially expressed in the ectoplacental cone and its derivatives. Because these proteinases are regulated by growth factors and cytokines in other tissues, the effect of leukaemia inhibitory factor (LIF) and epidermal growth factor (EGF) on their activity was investigated. Both LIF and EGF, like the proteinases, have been implicated in peri-implantation development. Blastocysts collected on day 4 of pregnancy were cultured 2 days in TCM 199 + 10% fetal bovine serum to allow outgrowth followed by 24 hour culture in defined media containing either LIF or EGF. Conditioned media were assayed for uPA activity by a chromogenic assay and MMP activity by gelatin zymography. Both LIF and EGF stimulated uPA and MMP-9 activity in blastocyst outgrowths after 3 days of culture (day 7). Proteinase activity was assayed again at the 5th to 6th day of culture (day 9 to 10). EGF was found to have no effect whereas LIF decreased production of both proteinases. These results demonstrate that proteinase activity in early embryos can be regulated by growth factors and cytokines during the implantation process and, in particular, they demonstrate the possible involvement of LIF in establishment of the correct temporal programme of proteinase expression.
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- 1995
40. Differential effects of transforming growth factor- 1 on the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in young and old human fibroblasts
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Edwards, D. R., Leco, K. J., Beaudry, P. P., Atadja, P. W., Veillette, C., and Riabowol, K. T.
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- 1996
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41. Expression and Activity of Ovarian Tissue Inhibitors of Metalloproteinases during Pseudopregnancy in the Rat1
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Nothnick, Warren B., Edwards, Dylan R., Leco, Kevin J., and Curry, Thomas E.
- Abstract
The present study examined the role of tissue inhibitors of metalloproteinases ITIMPs) in tissue remodeling that occurs during luteal development and regression throughout pseudopregnancy in the rat. Pseudopregnancy was induced in immature female rats by eCG/ hCG priming. Animals (n = 4 per time point) were killed on Days 1, 2, 4, 8, 12, 14, and 16 of pseudopregnancy (post hCG administration), and ovaries were removed and analyzed for metalloproteinase inhibitor activity or TIMP-1, TIMP-2, and TIMP-3 mRNA expression. Inhibitory activity was highest in Day-1 samples (41.35 ± 6.50 inhibitory units), and inhibitor activity significantly decreased ( p< 0.05) thereafter to minimal values at Day 12 (8.14 ± 2.71 inhibitory units). Methylamine hydrochloride treatment, which inactivates macroglobulin-type inhibitors, revealed that the majority of the inhibitor activity in the Day-1 samples (82.6%) and the Day-16 samples (77.3%) could be attributed to TIMPs. To further distinguish the contribution of each TIMP to this activity, Northern analysis for TIMP-1, −2, and −3 was performed. Analysis of TIMP mRNA expression revealed that TIMP-1 transcript expression was highest (p= 0.00009) at Day 1, decreased approximately 3- to 20-fold from Days 2 to 12, respectively, and again increased at Days 14–16. However, TIMP-2 expression did not change (p> 0.05) over any of the time points studied. In contrast to TIMP-1 and TIMP-2 expression, TIMP-3 mRNA expression was lowest during Days 1 and 2 of pseudopregnancy, increased approximately 4-fold at Day 4, peaked at Day 8, and remained elevated throughout the remainder of pseudopregnancy. We conclude from these studies that TIMPs play a role in the regulation of connective tissue remodeling associated with luteal development and regression. Furthermore, the distinct pattern of expression of the three TIMPssuggests that each may regulate either the site and extent of proteolytic action or specific matrix metalloproteinases at different periods of the luteal life span.
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- 1995
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42. Matrix metalloproteinase-9 maps to the distal end of chromosome 2 in the mouse
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Leco, Kevin J., Harvey, Mark B., Hogan, Aileen, Copeland, Neal G., Gilbert, Debra J., Jenkins, Nancy A., Edwards, Dylan R., and Schultz, Gilbert A.
- Abstract
The activity and expression of matrix metalloproteinase-9/gelatinase B (MMP-9), an enzyme implicated in the implantation process in mice, was investigated in normal and parthenogenetic blastocyst outgrowths. Conditioned media from parthenogenetic blastocysts after 4 days of culture had reduced levels of MMP-9 activity compared to conditioned medium from normal outgrowths. Levels of MMP-9 mRNA assayed by reverse transcription-polymerase chain reaction methods were also reduced in parthenogenetic blastocysts compared to normal outgrowths. Genetic mapping studies showed that Mmp9 maps to the distal end of chromosome 2 near the proximal boundary of a region affected by genomic imprinting. Both parental alleles of Mmp9, however, are expressed in 11.5-day embryos derived from interspecific crosses of Mus musculus and Mus spretus. Thus, loss of MMP-9 activity in parthenogenetic blastocysts does not appear to be due to imprinting but, rather, due to a defect of trophoblast giant cell proliferation and differentiation. Dev. Genet. 21:5560, 1997. © 1997 Wiley-Liss, Inc.
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- 1997
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43. Protocol for assessing mortality reduction with the early use of noninvasive ventilation in prehospital emergency services: A multicentre, observational cohort study in Madrid, Spain
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Horrillo García, C., Cintora Sanz, A.M., Gutierrez Misis, A., Gómez-Morán Quintana, M., Torres Poza, A., Carrillo Fernández, O., Rendo Murillo, J.A., Perez Alonso, A.M., Pastor Cabanillas, L., Carrillo Fernández, A., Chaya Romero, C., Carlos García Oliva, R., Mazuecos Muñoz, D., Mir Montero, M., Leco Gil, N., Parejo García, L., Rubio Riballo, A.B., Canales Corcho, I., Barreiro Martínez, C., Ibáñez Concejo, A.T., del Caño Garrido, A., Fernández Egido, C., García Herrero, G.M., Borge Toledano, G., Lafuente Durá, J.M., Lacalle Calleja, E., Escorial Sanz, O., Parada Otte, V., López Martín, S., Morales Pérez, J., Miguens Blanco, I., Lafuente Saenz, R., Uzurriaga Matín, M., Rubio Chacón, C., Blázquez, Victoria Cantó, Rodríguez Rodríguez, Oscar, Gómez de la Oliva, Soledad, Benavent, Eva García, Pérez, Armando Antequeira, Gonzalez Viñolis, Manuel Jesús, García, Yolanda Aranda, Pérez, Alberto Albiñana, Frandes, Marta Rincón, Martín Jimenez, Maria Luisa, Fernández del Blanco, Camino, Gonzalez, Raquel Barrós, Pareja, Yanet Dueñas, and Benito, Elena Pastor
- Abstract
Acute respiratory failure (ARF) has become one of the most prevalent serious pathologies encountered in the emergency medical service (EMS). In hospital settings, noninvasive ventilation (NIV) therapy prevents complications from more aggressive treatments for that condition. However, the scarce evidence on the benefits of NIV in prehospital EMS (i.e., during transport to the hospital) is inconclusive.
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- 2021
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44. Abstracts
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Barthelemy, O., Silvain, J., Brieger, D., Bellemain-Appaix, A., Cayla, G., Beygui, F., Lancar, R., Collet, J.P., Mercadier, A., Montalescot, G., Cha, K.S., Nam, Y.H., Kim, J.H., Park, S.Y., Park, T.H., Kim, M.H., Kim, Y.D., Lee, H.C., Ahn, M.S., Hong, T.J., Blanco, R., Blanco, F., Szarfer, J., Garcia Escudero, A., Gigena, G., Gagliardi, J., Rodriguez, A., Sarmiento, R., Affatatto, S., Riccitelli, M., Petris, A., Datcu, M.D., Pop, C., Radoi, M., Arsenescu-Georgescu, C., Petrescu, I., Petrescu, L., Serban, L., Nechita, E., Tatu-Chitoiu, G., Tatu-Chitoiu, G., Dorobantu, M., Benedek, I., Craiu, E., Sinescu, C., Ionescu, D.D., Radoi, M., Pop, C., Ginghina, C., Minescu, B., Izzo, A., Mantovani, P., Tomasi, L., Dalloglio, L., Bonatti, S., Rosiello, R., Romano, M., Agostini, F., Zanini, R., Zhao, Z.Y., Wu, Y.J., Li, J.J., Yany, Y.J., Qian, H.Y., Tang, Y.D., Timoteo, A.T., Toste, A., Lousinha, A., Ramos, R., Oliveira, J.A., Ferreira, M.L., Ferreira, R.C., Cabades, C., Diez Gil, J.L., Aguar, P., Sanmiguel, D., Lopez-March, A., Marmol, R., Guerra, L., Girbes, V., Ferrando, J., Rincon De Arellano, A., Timoteo, A.T., Ramos, R., Toste, A., Oliveira, J.A., Patricio, L., Ferreira, M.L., Ferreira, R.C., Blondal, M., Ainla, T., Marandi, T., Eha, J., Timoteo, A.T., Oliveira, M.M., Silva, M.N., Cunha, P.S., Feliciano, J., Silva, S., Ferreira, R.C., Kanovsky, J., Kala, P., Parenica, J., Poloczek, M., Prymusova, K., Kubkova, L., Spinar, J., Olinic, D., Homorodean, C., Ober, M., Olinic, M., Andrioaia, C., Condac, A., Masmoudi, M., Berdaoui, B., Labidi, S., Tapia Ballesteros, C., Hernandez Luis, C., Sandin, M.G., Vegas, J.M., Andion, R., Martinez, N., Gonzalez, I.A., Alvarado, M., Amat, I.J., San Roman, J.A., Garcia Gonzalez, M.J., Arroyo Ucar, E., Hernandez Garcia, C., Dorta Martin, M., Marrero Rodriguez, F., Dragu, R., Kapeliovich, M., Hammerman, H., Silva, D., Cortez-Dias, N., Jorge, C., Silva Marques, J., Carilho Ferreira, P., Robalo Martins, S., Almeida Ribeiro, M., Calisto, C., Fiuza, M., Lopes, M.G., Milicevic, P., Panic, M., Stankovic, I., Milicevic, D., Kalezic, T., Kafedzic, S., Ilic, I., Cerovic, M., Putnikovic, B., Neskovic, A., Rott, D., Leibowitz, D., Monhart, Z., Reissigova, J., Grunfeldova, H., Jansky, P., Timoteo, A.T., Valente, B., Oliveira, J.A., Ferreira, M.L., Ferreira, R.C., Villanueva Benito, I., Solla, I., Paredes, E., Diaz Castro, O., Calvo, F., Baz, J.A., Iniguez, A., Aleksova, A., Gerloni, R., Belfiore, R., Carriere, C., Barbati, G., Fabris, E., Possa, F., Nait, D., Milo, M., Sinagra, G., Marques, N., Mimoso, J., Gomes, V., Agra Bermejo, R.M., Emad Abu Assi, E.A.A., Sergio Raposeiras Roubin, S.R.R., Pilar Cabanas Grandio, P.C.G., Carlos Pena Gil, C.P.G., Jose Maria Garcia Acuna, J.M.G.A., Jose Ramon Gonzalez Juanatey, J.R.G.J., Daly, M.J., Scott, P., Owens, C.G., Tomlin, A., Smith, B., Adgey, A.A.J., Alvarez-Contreras, L.R., Juarez, U., Altamirano, A., Arias, A., Alvarez-San Gabriel, A., Gonzalez-Pacheco, H., Martinez-Sanchez, C., Rahnavardi, M., Keshtkar-Jahromi, M., Vakili, H., Gholamin, S., Razavi, S.M., Gilis-Januszewski, T., Mellwig, K.-P., Wiemer, M., Gilis-Januszewski, J., Peterschroeder, A., Koerfer, J., Horstkotte, D., Vrsalovic, M., Getaldic, B., Vrkic, N., Pintaric, H., Khan, S., Wasan, B., Moretti, L., Grossi, P., Silenzi, S., Testa, M., Candelori, L., Clementi, L.N., Forlini, M., Lando, L., Pezzuoli, M.L., Corradetti, P., Leurent, G., Pennec, P.Y., Filippi, E., Moquet, B., Hacot, J.P., Druelles, P., Rialan, A., Rouault, G., Coudert, I., Le Breton, H., Gevaert, S., Tromp, F., Vandecasteele, E., De Somer, F., Van Belleghem, Y., Bouchez, S., Martens, F., Herck, I., De Pauw, M., Spinar, J., Ludka, O., Sepsi, M., Miklik, R., Dusek, L., Tomcikova, D., Marques, N., Mimoso, J., Gomes, V., Garcia-Acuna, J.M., Aguiar-Souto, P., Raposeiras Roubin, S., Agra-Bermejo, R., Jacquet, M., Abu-Assi, E., Gonzalez-Juanatey, J.R., Ibatov, A., Labrova, R., Spinar, J., Karlik, R., Kanovsky, J., Lokaj, P., She, Q., Deng, S.B., Huang, S.H., Gu, L.J., Rong, J.I.A.N., Wu, Z.K., Li, Y., Zhang, J., Parascan, L., Campanile, A., Spinelli, L., Santulli, G., Ciccarelli, M., De Gennaro, S., Assante Di Panzillo, E., Trimarco, B., Iaccarino, G., Bobescu, E., Radoi, M., Datcu, G., Dobreanu, D., Doka, B., Charniot, J.-C., Cosson, C., Albertini, J.P., Bittar, R., Giral, P., Cherfils, C., Guillerm, E., Bonnefont-Rousselot, D., Craiu, E., Rusali, A., Cojocaru, L., Parepa, I., Koizumi, T., Iida, S., Sato, J., Kikutani, T., Muramatsu, T., Nishimura, S., Komiyama, N., Lee, W.P., Ong, B.B., Haralambos, K., Townsend, D., Rees, J.A.E., Williams, E.J., Halcox, J.P., Mcdowell, I., Damjanovic, M., Koracevic, G., Djordjevic-Radojkovic, D., Pavlovic, M., Krstic, N., Ciric-Zdravkovic, S., Stojkovic, A., Perisic, Z., Apostolovic, S., Faustino, A., Seca, L., Barra, S., Caetano, F., Providencia, R., Silva, J., Gomes, P., Costa, G., Costa, M., Leitao-Marques, A., Volkova, A.L., Arutyunov, G.P., Bylova, N.A., Dayter, I.I., Jao, Y.T.F.N., Fang, C.C., Chen, Y., Yu, C.L., Wang, S.P., Valencia, J., Perez-Berbel, P., Ruiz-Nodar, J.M., Pineda, J., Bordes, P., Quintanilla, M., Mainar, V., Sogorb, F., Santos, N., Serrao, M., Cafe, H., Silva, B., Oliveira, R., Caires, G., Drumond, A., Araujo, J., Providencia, R.A., Gomes, P.L., Seca, L., Barra, S., Silva, J., Faustino, A., Caetano, F., Pais, J.R., Mota, P., Leitao-Marques, A.M., Farhan, S., Jarai, R., Tentzeris, I., Vogel, B., Freynhofer, M.K., Wojta, J., Huber, K., Poli, M., Trambaiolo, P., Corsi, F., De Luca, M., Mustilli, M., Lukic, V., Simonetti, M., Ferraiuolo, G., Lettino, M., Casella, G., Conte, M.R., De Luca, L., Geraci, G., Ceravolo, R., Milo, M., Pani, A., Trambaiolo, P., Fradella, G., Schratter, A., Thiele, H., Klemm, T., Demmin, K., Lehmann, D., Mende, M., Schuler, G., Pittl, U., Chernova, A., Nikulina, S.U., Naruke, T., Inomata, T., Yanagisawa, T., Maekawa, E., Mizutani, T., Shinagawa, H., Nishii, M., Takeuchi, I., Takehana, H., Izumi, T., Paulo, C., Mascarenhas, J., Patacho, M., Pimenta, J., Bettencourt, P., Nardai, S., Szabo, G.Y., Berta, B., Edes, I., Merkely, B., Delgado Silva, J., Seca, L., Baptista, R., Providencia, R., Mota, P., Costa, M., Leitao-Marques, A., Faria, R., Trigo, J., Gago, P., Mimoso, J., Marques, N., Gomes, V., Gheorghe, G., Nanea, I.T., Cristea, A., Almarichi, S., Martins, H., Saraiva, F., Baptista, R., Jorge, E., Mendes, P.L., Monteiro, P., Costa, S., Franco, F., Providencia, L.A., Nanea, T., Gheorghe, G.S., Visan, S., Paun, N., Gaber, R., Gaber, R., Delewi, R., Nijveldt, R., De Bruin, H.A., Hirsch, A., Van Der Laan, A., Bouma, B.J., Tijssen, J.P.G., Van Rossum, A.C., Zijlstra, F., Piek, J.J., Rus, H., Radoi, M., Donea, M., Ciurea, C., Ifteni, G., Casolo, G., Chioccioli, M., Magnacca, M., Del Meglio, J., Comella, A., Baratto, M., Lera, J., Salvadori, L., Tessa, C., Vignali, C., Keca, Z., Momcilov Popin, T., Panic, G., White, R., Mateen, F., Weaver, A., Dragu, R., Agmon, Y., Kapeliovich, M., Hammerman, H., Timoteo, A.T., Lousinha, A., Santos, N., Oliveira, J.A., Ferreira, M.L., Ferreira, R.C., Okisheva, E., Tsaregorodtsev, D., Sulimov, V., Amat Santos, I.J., Gonzalez, I.A., Hernandez, C., Sandin, M.G., Tapia, C., Andion, R., Alvarado, M., Campo, A., San Roman, J.A., Fredman, D., Svensson, L., Rosenqvist, M., Tadel-Kocjancic, S., Radsel, P., Knafelj, R., Gorjup, V., Noc, M., Zima, E., Jenei, Z.S., Kovacs, E., Osztheimer, I., Szabo, G.Y., Molnar, L., Horvath, A., Becker, D., Geller, L., Merkely, B., Maggi, R., Furukawa, T., Viscardi, V., Brignole, M., Leal, S.R.N., Dores, H., Rosario, I., Monge, J., Carvalho, M.J., Arroja, I., Leitao, A., Fonseca, C., Aleixo, A., Silva, A., Keuleers, S., Herijgers, P., Herregods, M.C., Budts, W., Dubois, C., Meuris, B., Verhamme, P., Flameng, W., Van De Werf, F., Adriaenssens, T., Badran, H., Elnoamany, M., Lolah, T., Tatu-Chitoiu, G., Dorobantu, M., Benedek, I., Craiu, E., Sinescu, CRINA., Ionescu, D.D., Olariu, C., Radoi, M., Pop, C., Macarie, C., Mollik, M.A.H., 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Ishihara, T., Hanafusa, T., Belohlavek, J., Rohn, V., Kunstyr, J., Lips, M., Semrad, M., Horak, J., Mlejnsky, F., Tosovsky, J., Linhart, A., Lindner, J., Sablik, Z., Samborska-Sablik, A., Drozdz, J., Gaszynski, W., Ferrer Hita, J.J., Rodriguez-Gonzalez, A., Izquierdo-Gomez, M.M., Enjuanes-Grau, C., Rubio-Iglesias-Garcia, C., Sanchez-Grande-Flecha, A., Juarez-Prera, R., Blanco-Palacios, G., Bosa-Ojeda, F., Marrero-Rodriguez, F., Lakhdar, R., Drissa, M., Drissa, M., Jedaida, B., Drissa, H., Sousa, O., Dias Ferreira, N., Sampaio, F., Caeiro, D., Fontes-Carvalho, R., Silva, G., Pereira, E., Ribeiro, J., Albuquerque, A., Gama Ribeiro, V., Hsin, H.-T., Huang, J.-H., Chiu, K.-M., Chen, Z.-S., Lin, P.-C., Chen, L.-Y., Chu, S.-H., Efthimiadis, I., Skendros, P., Sarantopoulos, A., Boura, P., Delewi, R., Nijveldt, R., Van Der Laan, A.M., Hirsch, A., Van Der Vleuten, P.A., Klees, M., Tijssen, J.G.P., Zijlstra, F., Van Rossum, A.C., Piek, J.J., Backus, B.E., Six, A.J., Kelder, J.H., Mosterd, A., 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I.A., Duro Aguado, I.A., Palomino Doza, A.J., Gomez Salvador, I., San Roman Calvar, J.A., Nikishin, A.G., Mamarasulov, T.M., Pirnazarov, M.M., Koracevic, G., Pavlovic, M., Glasnovic, J., Damjanovic, M., Stojkovic, A., Kostic, T., Todorovic, L., Petrovic, S., Zivkovic, M., Djordjevic-Radojkovic, D., Cherneva, Z.C.H., Denchev, S.D., Heltai, K., Becker, D., Merkely, B., Nikulina, N., Yakushin, S.S., Akinina, S.A., Furmenko, G.I., Boytsov, A., Yakushin, S.S., Nikulina, N.N., Furmenko, G.I., Akinina, S.A., Dores, H., Leal, S., Rosario, I., Bronze, L., Abecasis, J., Correia, M.J., Arroja, I., Fonseca, C., Aleixo, A., Silva, A., Dores, H., Leal, S., Rosario, I., Monge, J., Abecasis, J., Correia, M.J., Bronze, L., Arroja, I., Aleixo, A., Silva, A., Rosario, I., Leal, S., Dores, H., Correia, M.J., Monge, J.C., Abecasis, J., Arroja, I., Aleixo, A., Silva, A., Palmisano, P., Zaccaria, M., Zanna, D., Marangelli, V., Caiati, C., Ciccone, M.M., Favale, S., Picon Heras, R., Loureiro, M.J., Nunez-Gil, I., Garcia Rubira, J.C., Acebal, C., Ruiz-Mateos, B., Ibanez, B., Fernandez-Ortiz, A., Macaya, C., Rosario, I., Dores, H., Leal, S., Monge, J.C., Correia, M.J., Bronze Carvalho, L., Arroja, I., Fonseca, C., Aleixo, A., Silva, A., Urazovskaya, I., Vinogradova, D., Vasilieva, E., Shpektor, A., Faustino, A., Seca, L., Barra, S., Providencia, R., Silva, J., Gomes, P., Costa, G., Caetano, F., Costa, M., Leitao-Marques, A., Conti, E., Musumeci, M.B., Lauri, F.M., Dito, E., De Giusti, M., Lallo, A., Fusco, D., Davoli, M., Volpe, M., Autore, C., Gamra, H., Dridi, Z., Hassine, M., Addad, F., Gherissi, I., Reda, A., Mahjoub, M., Bouraoui, S., Abdennadher, M., Betbout, F., Mota, P.M.F.P., Silva, J.D., Providencia, R.A., Leitao-Marques, A., Nikolic Heitzler, V., Babic, Z., Milicic, D., Bergovec, M., Raguz, M., Mirat, J., Strozzi, M., Plazonic, Z., Giunio, L., Steiner, R., Stanojevic, D., Apostolovic, S., Jankovic Tomasevic, R., Pavlovic, M., Djordjevic, V., Djordjevic Radojkovic, D., Salinger Martinovic, S., Koracevic, G., Damjanovic, M., Ilic, I., Scafa Udriste, A., Fruntelata, A., Gainoiu, E., Bogdan, S., Calmac, L., Zamfir, D., Teodorescu, C., Guran, M., Constantinescu, D., Dorobantu, M., Rosario, I., Dores, H., Leal, S., Abecasis, J., Monge, J.C., Bronze, L., Arroja, I., Fonseca, C., Aleixo, A., Silva, A., Konopka, A., Banaszewski, M., Wojtkowska, I., Stepinska, J., Vidergold, J.V., Osipova, I.V., Tavrovskaya, T.V., Galkina, J.V., Timofeev, A.V., Vorobyov, R.I., Vorobyova, E.N., Matos, L., Carvalho, A.C.C., Oliveira, W., Cintra, F., Poyares, D., Andersen, M., Martins, R., Tufik, S., Neuzil, P., Ostadal, P., Skoda, J., Holy, F., Holdova, K., Brada, J., Horakova, S., Mlcek, M., Hrachovina, V., Kittnar, O., Gorudko, I.V., Buko, I.V., Cherenkevich, S.N., Polonetsky, L.Z., Plotkin, V.Y., Timoshina, M.A., Azanchevskaya, S.V., Chromov-Borisov, N.N., Vorlat, A., Snoep, L., Claeys, M.J., Vrints, C.J., Palazzuoli, A., Caputo, M., Quatrini, I., Calabro, A., Antonelli, G., Campagna, M.S., Franci, B., Nuti, R., Maisel, A., Paulo, C., Mascarenhas, J., Patacho, M., Pimenta, J., Bettencourt, P., Negrini, M., Minora, T., Marino, P., Seregni, R., Tavlueva, E., Barbarash, O., Barbarash, L., Janota, T., Kudlicka, J., Malik, K., Wichterle, D., Hradec, J., Faria, R., Mimoso, J., Marques, N., Trigo, J., Marques, V., Gomes, V., Body, R., Carley, S.D., Mcdowell, G., Nuttall, M., Wibberley, C., France, M., Cruickshank, J.K., Mackway-Jones, K., Cavusoglu, Y., Cavusoglu, A., Unluoglu, I., Tek, M., Demirustu, C., Unalacak, M., Gorenek, B., Birdane, A., Yuksel, F., Ata, N., Leon, M., Cozma, C., Mitu, F., Matos, L., Carvalho, A.C.C., Almeida, D.R., Oliveira, W., Dias, C.B., Barra, S.N.C., Gomes, P., Silva, J., Providencia, R., Seca, L., Leitao Marques, A., Burazor, I., Burazor, M., Krstic, M., Lazovic, M., Stojkovic, A., Vukmanovic, M., Djordjevic, J., Radovanovic, Z., Ilic, D., Bosnjakovic, P., Margato, R., Ferreira, A.C., Mateus, P.S., Ribeiro, H., Fontes, P., Moreira, J.I., Teixeira, T., Silva, J.D., Costa, M., Leitao-Marques, A., Conte, G., Menozzi, A., Solinas, E., Bolognesi, M.G., Tadonio, I., Mantovani, F., Cattabiani, A., Vignali, L., Ardissino, D., Scafa Udriste, A., Fruntelata, A., Tautu, O., Calmac, L., Alexandrescu, A., Niculescu, R., Tatu-Chitoiu, G., Dorobantu, M., Djordjevic Radojkovic, D., Apostolovic, S., Perisic, Z., Damjanovic, M., Jankovic, R., Salinger Martinovic, S., Koracevic, G., Todorovic, L., Bozinovic, N., Matos, L., Carvalho, A.C.C., Almeida, D.R., Oliveira, W., Dias, C.B., Santos, C., Ferreira, J., Carmo, P., Costa, F., Brito, J., Sousa, P., Cardoso, G., Correia, I., Aguiar, C., Silva, A., Fountoulaki, K., Kastellanos, S., Voltirakis, E., Kokotos, A., Michalakeas, C., Kontsas, K., Hasioti, K., Iliodromitis, E.T., Anastasiou-Nana, M., Andion Ogando, R., Hernandez Luis, C., Sandin Fuentes, M.G., Tapia Ballesteros, C., Vegas Valle, J.M., Zatarain Nicolas, E., Amat Santos, I.J., Martinez Uruena, N., Alvarado Montes De Oca, M., San Roman Calvar, J.A., Belohlavek, J., Dytrych, V., Kovarnik, T., Smid, O., Kral, A., Linhart, A., Aroutunov, A.G., Intwala, S., Sondore, D., Juhnevica, D., Trusinskis, K., Strenge, K., Jegere, I., Narbute, I., Grave, A., Erglis, A., Shaalan, H.S.H., Pagava, Z., Agladze, R., Shakarishvili, R., Sharashidze, N., Gujejiani, L., Saatashvili, G., Martins, H., Saraiva, F., Baptista, R., Jorge, E., Mendes, P.L., Monteiro, P., Costa, S., Franco, F., Providencia, L.A., Gaber, R., Gaber, R., Hristova, K., Katova, T.Z., Kostova, V., Simova, Y., Parepa, I., Suceveanu, A.I., Suceveanu, A., Mazilu, L., Voinea, F.L., Craiu, E., Obradovic, S., Salinger, S., Vukotic, S., Rafajlovski, S., Romanovic, R., Koracevic, G., Antonijevic, N., Gligic, B., Hutyra, M., Skala, T., Horak, D., Vindis, D., Taborsky, M., Contine, A., Del Pinto, M., Angeli, F., Verdecchia, P., Borgognoni, F., Grikstaite, E., Pantano, P., Ambrosio, G., Cavallini, C., Bonanad, C., Sanchis, J., Bodi, V., Nunez, J., Bosch, X., Heras, M., Pellicer, M., Llacer, A., Seca, L.F., Fontes-Carvalho, R., Caeiro, D., Adao, L., Oliveira, M., Goncalves, H., Primo, J., Gama, V., Fresco, C., De Biasio, M., Sappa, R., Muser, D., Morocutti, G., Bernardi, G., Proclemer, A., Lombardi, C., Metra, M., Bugatti, S., Pasotti, E., Quinzani, F., Adamo, M., Villa, C., Rovetta, R., Manerba, A., Dei Cas, L., Mariani, M., Dushpanova, A., Baroni, M., Cerone, E., Nardelli, A., Gianetti, J., Berti, S., Timoteo, A.T., Oliveira, M.M., Silva, M.N., Toste, A., Ramos, R., Cunha, P.S., Feliciano, F., Soares, R., Santos, S., Ferreira, R.C., Ostadal, P., Kruger, A., Vondrakova, D., Herget, J., Di Maio, R.C., Navarro, C., Cromie, N.A., Anderson, J.M.C., Adgey, J.A.A., Tadel-Kocjancic, S., Radsel, P., Knafelj, R., Gorjup, V., Noc, M., Caeiro Pereira, D., Braga, P., Fontes Carvalho, R., Sousa, O., Rodrigues, A., Goncalves, H., Ribeiro, J., Goncalves, M., Simoes, L., Gama, V., and Borisov, K.V.
- Abstract
Background: Radial access for PCI is increasing but its use in emergency still remains confidential. We report our single center experience where all interventional cardiologists use the radial access as default strategy for primary PCI. Methods and Results: STEMI patients (n = 671) were evaluated for bleeding complications using a web-based registry (e-PARIS). In-hospital bleeding was adjudicated using various definitions (TIMI, GUSTO, STEEPLE). MACE was the composite of death, MI and stroke. In this non-selected, high risk population, 6.1% had cardiogenic shock on admission, 3.9% out-of-hospital cardiac arrest and 51.2% multivessel disease. Radial access (88%) was the default strategy as was abciximab (78%). Clopidogrel loading dose ranged from 300 to 900 mg. Pre-hospital fibrinolysis was used in 7.1%. Hemodynamic support devices (IABP, ECMO, Tandem Heart) were needed in 7.0%. In-hospital bleeding rates varied widely according to the definitions used: 2.5%, 1.5%, 5.7%, 9.2% and 10.9% with TIMI Major, GUSTO Severe, TIMI Major/minor, GUSTO Severe/moderate or STEEPLE Major, respectively. In-hospital death rate was 5.5%. One-year mortality (8.2%) was seriously impacted by in-hospital bleeding (31.6% vs 6.8%, p < 0.001). The most frequent bleeding site was gastro-intestinal (figure). GUSTO Severe/moderate bleeding was independently correlated with MACE (OR 2.60; 95%CI 1.21–5.59; p = 0.01) and radial access was a strong predictor of survival (OR 0.33; 95%CI 0.17–0.56; p = 0.002). Conclusions: The gastro-intestinal tract is the most frequent site of bleeding when the radial artery is the predominant vascular access site for primary PCI. GUSTO Severe/moderate bleeding is an independent predictor of MACE while radial access predicts survival.
- Published
- 2010
- Full Text
- View/download PDF
45. 1.P.226 The apolipoprotein E4 allele is not associated with an atherogenic lipid profile in a native-American population following its traditional lifestyle
- Author
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Aguilar, Carlos A., Pedro-Botet, Juan, Ordovas, Jose M., Talavera, Guadalupe, Guillén, Luz M., Barriguete, Jorge A., Leco, Marta E., Gonzalez-Barranco, Jorge, Gómez-Pérez, Francisco J., and Rull, Juan A.
- Published
- 1997
- Full Text
- View/download PDF
46. Endocrinology and paracrinology: Roles of growth factors during peri-implantation development
- Author
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Harvey, M.B., Leco, K.J., Arcellana-Panlilio, M.Y., Zhang, X., Edwards, D.R., and Schultz, G.A.
- Abstract
Several growth factor ligand and receptor gene products have been shown to play roles during preimplantation mammalian development. Genes for insulin-like growth factors (IGFs), transforming growth factors (TGFs), fibroblast growth factor (FGF), platelet-derived growth factor (PDGF) and receptors for insulin, IGF, PDGF, TGFα and epidermal growth factor (EGF) are expressed by early embryos of several species including mouse, rat, cow and sheep. Roles of growth factors during early development have been demonstrated by addition of purified growth factors to culture medium or by molecular genetic techniques that interfere with gene expression. In this way, it has been shown that successful development of the blastocyst is dependent on the action of epidermal growth factor (EGF) and leukaemia inhibitory factor (LIF). Recent experiments show that both LIF and EGF stimulate secretion of urokinase-type plasminogen activator (uPA) and gelatinase B/ matrix metalloproteinase-9 (MMP-9) in day 7 mouse blastocyst outgrowths. At the same time, tissue inhibitors of MMPs (TIMPs) are also expressed by embryonic, decidual and uterine tissues during the implantation process. It appears that LIF may act directly or indirectly, by inducing the expression of other cytokines, to regulate the temporal and spatial production and activity of proteases and protease inhibitors to create a favourable environment for implantation.
- Published
- 1995
47. The roles of tissue inhibitors of metalloproteinases in tissue remodelling and cell growth.
- Author
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Edwards DR, Beaudry PP, Laing TD, Kowal V, Leco KJ, Leco PA, and Lim MS
- Subjects
- Animals, Extracellular Matrix metabolism, Gene Expression Regulation, Glycoproteins genetics, Humans, Metalloendopeptidases metabolism, Signal Transduction, Tissue Inhibitor of Metalloproteinases, Cell Division physiology, Glycoproteins physiology
- Abstract
Tissue inhibitors of metalloproteinases (TIMPs) are secreted proteins that block the activities of the extracellular matrix (ECM)-degrading metalloproteinases (MMPs). As key determinants of ECM integrity and turnover, TIMPs are involved in the establishment and maintenance of tissue architecture and may indirectly influence ECM-dependent cells signaling. In addition, TIMPs exert both positive and negative effects on cell growth through mechanisms that are independent of MMP inhibition. The three members of the mammalian TIMP family differ in structure, biochemical properties and expression, suggesting that they have distinct physiological roles. Here, we review recent advances in our understanding of TIMP protein function and gene regulation. We discuss the potential relevance of MMPs and TIMPs in obesity with regard to effects on the processing of tumor necrosis factor-alpha.
- Published
- 1996
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