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20 results on '"Leclerc, Sonia"'

4. Vascular contributions to 16p11.2 deletion autism syndrome modeled in mice

Author

Ouellette, Julie, Toussay, Xavier, Comin, Cesar H., Costa, Luciano da F., Ho, Mirabelle, Lacalle-Aurioles, María, Freitas-Andrade, Moises, Liu, Qing Yan, Leclerc, Sonia, Pan, Youlian, Liu, Ziying, Thibodeau, Jean-François, Yin, Melissa, Carrier, Micael, Morse, Cameron J., Dyken, Peter Van, Bergin, Christopher J., Baillet, Sylvain, Kennedy, Christopher R., Tremblay, Marie-Ève, Benoit, Yannick D., Stanford, William L., Burger, Dylan, Stewart, Duncan J., and Lacoste, Baptiste

Published
2020
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7. Astroglial Hmgb1 regulates postnatal astrocyte morphogenesis and cerebrovascular maturation.

Author

Freitas-Andrade, Moises, primary, Comin, Cesar H, additional, Van Dyken, Peter C, additional, Ouellette, Julie, additional, Raman-Nair, Joanna, additional, Blakeley, Nicole, additional, Liu, Quing Yan, additional, Leclerc, Sonia, additional, Pan, Youlian, additional, Liu, Ziying, additional, Carrier, Micael, additional, Thakur, Karan, additional, Savard, Alexandre, additional, Rurak, Gareth M, additional, Tremblay, Marie-Eve, additional, Salmaso, Natalina, additional, Costa, Luciano Da F, additional, Coppola, Gianfilippo, additional, and Lacoste, Baptiste, additional

Published
2023
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8. Application of blood brain barrier models in pre-clinical assessment of glioblastoma- targeting CAR-T based immunotherapies

Author

Jezierski, Anna, primary, Huang, Jez, additional, Li, Betty (Ying), additional, Charlebois, Claudie, additional, Nguyen, Tina, additional, Liu, Ziying, additional, Bloemberg, Darin, additional, Zafer, Ahmed, additional, Baumann, Ewa, additional, Sodja, Caroline, additional, Leclerc, Sonia, additional, Fewell, Gwen, additional, Liu, Qing, additional, Prabhakarpandian, Balabhaskar, additional, McComb, Scott, additional, and Stanimirovic, Danica B., additional

Published
2022
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9. Additional file 4 of Application of blood brain barrier models in pre-clinical assessment of glioblastoma-targeting CAR-T based immunotherapies

Author

Huang, Jez, Li, Ying Betty, Charlebois, Claudie, Nguyen, Tina, Liu, Ziying, Bloemberg, Darin, Zafer, Ahmed, Baumann, Ewa, Sodja, Caroline, Leclerc, Sonia, Fewell, Gwen, Liu, Qing, Prabhakarpandian, Balabhaskar, McComb, Scott, Stanimirovic, Danica B., and Jezierski, Anna

Abstract

Additional file 4: Table S1. Detailed information about antibodies used in the study. Table S2. Median Fluorescence Intensity (MFI) of immune cell adhesion molecules with and without stimulation.

Published
2022
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10. Additional file 3 of Application of blood brain barrier models in pre-clinical assessment of glioblastoma-targeting CAR-T based immunotherapies

Author

Huang, Jez, Li, Ying Betty, Charlebois, Claudie, Nguyen, Tina, Liu, Ziying, Bloemberg, Darin, Zafer, Ahmed, Baumann, Ewa, Sodja, Caroline, Leclerc, Sonia, Fewell, Gwen, Liu, Qing, Prabhakarpandian, Balabhaskar, McComb, Scott, Stanimirovic, Danica B., and Jezierski, Anna

Abstract

Additional file 3: Movie S1. Real-time post-BBB CAR-T/T cell mediated in U87vIII killing. Real-time movies of post-BBB extravasation of CAR-F263 and CAR-F269 mediated killing of U87vIII-mKate2 cells acquired via Incucyte. No T cell is shown as a control of U87vIII proliferation in the absence of anti-EGFRvIII-CAR-targeted killing. Movies are shown over a 48 h time course. Scale bar = 200 µm. Movie S2. Set-up of blood-brain-tumor barrier (BBTB)-on-CHIP model system using SynBBB. Real-time movie showing immunofluorescence images of the SynBBB blood-brain-tumor-barrier setup in the SynBBB chips with iBECs seeded in the middle channel (phase contrast image) and U87vIII-mKate2 cells (red) seeded in the two outer channels. CAR-F263 (green) perfusion can be seen within the middle iBEC channel; arrow indicating perfusion direction. Movie is played at 4 frames per second. Scale bar = 100 µm. Movie S3. Real-time movies of T cell interaction and extravasation across the middle iBEC channel. A-B Real-time phase contrast images showing evidence of T cell arrest and adhesion to the iBEC monolayer in the endothelial channel and extravasation across the 3 µm microfabricated pores. Movie is played at 4 frames per second. Scale bar = 50 µm. Movie S4. Real-time movies of CAR-F263 cell arrest and adhesion to iBECs. Real-time phase contrast images showing evidence of CAR-F263 cell arrest and adhesion to the iBEC monolayer in the middle channel. CAR-F263 labelled with CytoLight dye (green). Movie is played at 4 frames per second.

Published
2022
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13. Additional file 1 of Differential expression of receptors mediating receptor-mediated transcytosis (RMT) in brain microvessels, brain parenchyma and peripheral tissues of the mouse and the human

Author

Zhang, Wandong, Liu, Qing Yan, Arsalan S. Haqqani, Leclerc, Sonia, Ziying Liu, Fauteux, François, Baumann, Ewa, Delaney, Christie E., Ly, Dao, Star, Alexandra T., Brunette, Eric, Sodja, Caroline, Hewitt, Melissa, Jagdeep K. Sandhu, and Stanimirovic, Danica B.

Subjects
Data_FILES
Abstract

Additional file 1. Additional figures and tables.

Published
2020
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15. Differential expression of receptors mediating receptor-mediated transcytosis (RMT) in brain microvessels, brain parenchyma and peripheral tissues of the mouse and the human

Author

Zhang, Wandong, primary, Liu, Qing Yan, additional, Haqqani, Arsalan S., additional, Leclerc, Sonia, additional, Liu, Ziying, additional, Fauteux, Francois, additional, Baumann, Ewa, additional, Delaney, Christie E., additional, Ly, Dao, additional, Star, Alexandra T., additional, Brunette, Eric, additional, Sodja, Caroline, additional, Hewitt, Melissa, additional, Sandhu, Jagdeep K., additional, and Stanimirovic, Danica B., additional

Published
2020
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16. A differential expression of receptors mediating receptor-mediated transcytosis (RMT) in brain microvessels, brain parenchyma and peripheral tissues of the mouse and the human

Author

Zhang, Wandong, primary, Liu, Qing Yan, additional, Haqqani, Arsalan S., additional, Leclerc, Sonia, additional, Lei, Joy, additional, Fauteux, Francois, additional, Baumann, Ewa, additional, Delaney, Christie E., additional, Ly, Dao, additional, Star, Alexandra T., additional, Brunette, Eric, additional, Sodja, Caroline, additional, Hewitt, Melissa, additional, Sandhu, Jagdeep K., additional, and Stanimirovic, Danica B., additional

Published
2020
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18. Structure and active site residues of PdID, an N-acetyltransferase from the bacillosamine synthetic pathway required for N-glycan synthesis in Campylobacter jejuni

Author

Rangarajan, Erumbi S., Ruane, Karen M., Sulea, Traian, Watson, David C., Proteau, Ariane, Leclerc, Sonia, Cygler, Miroslaw, Matte, Allan, and Young, N. Martin

Subjects
Campylobacter -- Composition, Glycoproteins -- Structure, Glycoproteins -- Chemical properties, Protein folding -- Research, Biological sciences, Chemistry
Abstract

A study was conducted to determine the crystal structure and function of PgID enzyme in CoA-bound and unbound forms isolated from Campylobacter jejuni, highly unusual bacteria forming N-linked glycoproteins. The enzyme is found to be the member of L[beta]H family of complex sugar N-acetyltransferases which adopts an extended structure in the unbound form and folds to extend the [beta]-helix upon binding CoA.

Published
2008

20. Novel Transcriptional and Translational Biomarkers of Tularemia Vaccine Efficacy in a Mouse Inhalation Model: Proof of Concept.

Author

Liu, Qing Yan, Leclerc, Sonia, Pan, Youlian, Liu, Ziying, Stark, Felicity, and Conlan, Joseph Wayne

Subjects
TULAREMIA, FRANCISELLA tularensis, LABORATORY mice, PROOF of concept, BIOMARKERS, BIOLOGICAL weapons
Abstract

Francisella tularensis subspecies tularensis (Ftt) is extremely virulent for humans when inhaled as a small particle aerosol (<5 µm). Inhalation of ≥20 viable bacteria is sufficient to initiate infection with a mortality rate ≥30%. Consequently, in the past, Ftt became a primary candidate for biological weapons development. To counter this threat, the USA developed a live vaccine strain (LVS), that showed efficacy in humans against inhalation of virulent Ftt. However, the breakthrough dose was fairly low, and protection waned with time. These weaknesses triggered extensive research for better vaccine candidates. Previously, we showed that deleting the clpB gene from virulent Ftt strain, SCHU S4, resulted in a mutant that was significantly less virulent than LVS for mice, yet better protected them from aerosol challenge with wild-type SCHU S4. To date, comprehensive searches for correlates of protection for SCHU S4 ΔclpB among molecules that are critical signatures of cell-mediated immunity, have yielded little reward. In this study we used transcriptomics analysis to expand the potential range of molecular correlates of protection induced by vaccination with SCHU S4 ΔclpB beyond the usual candidates. The results provide proof-of-concept that unusual host responses to vaccination can potentially serve as novel efficacy biomarkers for new tularemia vaccines. [ABSTRACT FROM AUTHOR]

Published
2022
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