1. Iron-catalyzed borylation of alkyl electrophiles.
- Author
-
Atack TC, Lecker RM, and Cook SP
- Subjects
- Boronic Acids chemistry, Catalysis, Esters chemistry, Molecular Structure, Boronic Acids chemical synthesis, Esters chemical synthesis, Ferric Compounds chemistry, Hydrocarbons, Halogenated chemistry
- Abstract
The use of low-cost iron(III) acetoacetate (Fe(acac)3) and tetramethylethylenediamine (TMEDA) enables the direct cross-coupling of alkyl halides with bis(pinacolato)diboron. This approach allows for the borylation of activated or unactivated primary, secondary, and tertiary bromides. Moreover, even the borylation of benzylic or allylic chlorides, tosylates, and mesylates are possible. The reactions proceed under mild conditions at room temperature and show broad functional-group compatibility and "robustness" as measured by a modified Glorius robustness screen.
- Published
- 2014
- Full Text
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