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Background: Gliomas, including the most severe form known as glioblastomas, are primary brain tumors arising from glial cells, with significant impact on adults, particularly men aged 45 to 70. Recent advancements in the WHO (World Health Organization) classification now correlate genetic markers with glioma phenotypes, enhancing diagnostic precision and therapeutic strategies., Aims and Methods: This scoping review aims to evaluate the current state of deep learning (DL) applications in the genetic characterization of adult gliomas, addressing the potential of these technologies for a reliable virtual biopsy., Results: We reviewed 17 studies, analyzing the evolution of DL algorithms from fully convolutional networks to more advanced architectures (ResNet and DenseNet). The methods involved various validation techniques, including k-fold cross-validation and external dataset validation., Conclusions: Our findings highlight significant variability in reported performance, largely due to small, homogeneous datasets and inconsistent validation methods. Despite promising results, particularly in predicting individual genetic traits, the lack of robust external validation limits the generalizability of these models. Future efforts should focus on developing larger, more diverse datasets and integrating multidisciplinary collaboration to enhance model reliability. This review underscores the potential of DL in advancing glioma characterization, paving the way for more precise, non-invasive diagnostic tools. The development of a robust algorithm capable of predicting the somatic genetics of gliomas or glioblastomas could accelerate the diagnostic process and inform therapeutic decisions more quickly, while maintaining the same level of accuracy as the traditional diagnostic pathway, which involves invasive tumor biopsies.

In this article, we define a generic gradient for color and spectral images, considering a proposed taxonomy of the state of the art. A full-vector gradient, taking into account the sensor's characteristics, is in compliance with the metrological properties of genericity, robustness, and reproducibility. Here, we construct a protocol to compare gradients from different sensors. The comparison is developed by simulating sensors using their spectral characteristics. We develop three experiments using this protocol. The first experiment shows the consistency of results for similar sensors; the second demonstrates the genericity of the approach, adapted to any kind of imaging sensors; and the third focuses on the channel inter-correlation considering sensors such as in the color vision deficiency case.

Gradient extraction is important for a lot of metrological applications such as Control Quality by Vision. In this work, we propose a full-vector gradient for multi-spectral sensors. The full-vector gradient extends Di Zenzo expression to take into account the non-orthogonality of the acquisition channels thanks to a Gram matrix. This expression is generic and independent from channel count. Results are provided for a color and a multi-spectral snapshot sensor. Then, we show the accuracy improvement of the gradient calculation by creating a dedicated objective test and from real images.