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6. The Eurasian Modern Pollen Database (EMPD), version 2

Author

Davis, B, Chevalier, M, Sommer, P, Carter, V, Finsinger, W, Mauri, A, Phelps, L, Zanon, M, Abegglen, R, Akesson, C, Alba-Sanchez, F, Scott Anderson, R, Antipina, T, Atanassova, J, Beer, R, Belyanina, N, Blyakharchuk, T, Borisova, O, Bozilova, E, Bukreeva, G, Jane Bunting, M, Clo, E, Colombaroli, D, Combourieu-Nebout, N, Desprat, S, Di Rita, F, Djamali, M, Edwards, K, Fall, P, Feurdean, A, Fletcher, W, Florenzano, A, Furlanetto, G, Gaceur, E, Galimov, A, Galka, M, Garcia-Moreiras, I, Giesecke, T, Grindean, R, Guido, M, Gvozdeva, I, Herzschuh, U, Hjelle, K, Ivanov, S, Jahns, S, Jankovska, V, Jimenez-Moreno, G, Karpinska-Kolaczek, M, Kitaba, I, Kolaczek, P, Lapteva, E, Latalowa, M, Lebreton, V, Leroy, S, Leydet, M, Lopatina, D, Lopez-Saez, J, Lotter, A, Magri, D, Marinova, E, Matthias, I, Mavridou, A, Mercuri, A, Mesa-Fernandez, J, Mikishin, Y, Milecka, K, Montanari, C, Morales-Molino, C, Mrotzek, A, Sobrino, C, Naidina, O, Nakagawa, T, Nielsen, A, Novenko, E, Panajiotidis, S, Panova, N, Papadopoulou, M, Pardoe, H, Pedziszewska, A, Petrenko, T, Ramos-Roman, M, Ravazzi, C, Rosch, M, Ryabogina, N, Ruiz, S, Sakari Salonen, J, Sapelko, T, Schofield, J, Seppa, H, Shumilovskikh, L, Stivrins, N, Stojakowits, P, Svitavska, H, Swieta-Musznicka, J, Tantau, I, Tinner, W, Tobolski, K, Tonkov, S, Tsakiridou, M, Valsecchi, V, Zanina, O, Zimny, M, Davis B. A. S., Chevalier M., Sommer P., Carter V. A., Finsinger W., Mauri A., Phelps L. N., Zanon M., Abegglen R., Akesson C. M., Alba-Sanchez F., Scott Anderson R., Antipina T. G., Atanassova J. R., Beer R., Belyanina N. I., Blyakharchuk T. A., Borisova O. K., Bozilova E., Bukreeva G., Jane Bunting M., Clo E., Colombaroli D., Combourieu-Nebout N., Desprat S., Di Rita F., Djamali M., Edwards K. J., Fall P. L., Feurdean A., Fletcher W., Florenzano A., Furlanetto G., Gaceur E., Galimov A. T., Galka M., Garcia-Moreiras I., Giesecke T., Grindean R., Guido M. A., Gvozdeva I. G., Herzschuh U., Hjelle K. L., Ivanov S., Jahns S., Jankovska V., Jimenez-Moreno G., Karpinska-Kolaczek M., Kitaba I., Kolaczek P., Lapteva E. G., Latalowa M., Lebreton V., Leroy S., Leydet M., Lopatina D. A., Lopez-Saez J. A., Lotter A. F., Magri D., Marinova E., Matthias I., Mavridou A., Mercuri A. M., Mesa-Fernandez J. M., Mikishin Y. A., Milecka K., Montanari C., Morales-Molino C., Mrotzek A., Sobrino C. M., Naidina O. D., Nakagawa T., Nielsen A. B., Novenko E. Y., Panajiotidis S., Panova N. K., Papadopoulou M., Pardoe H. S., Pedziszewska A., Petrenko T. I., Ramos-Roman M. J., Ravazzi C., Rosch M., Ryabogina N., Ruiz S. S., Sakari Salonen J., Sapelko T. V., Schofield J. E., Seppa H., Shumilovskikh L., Stivrins N., Stojakowits P., Svitavska H. S., Swieta-Musznicka J., Tantau I., Tinner W., Tobolski K., Tonkov S., Tsakiridou M., Valsecchi V., Zanina O. G., Zimny M., Davis, B, Chevalier, M, Sommer, P, Carter, V, Finsinger, W, Mauri, A, Phelps, L, Zanon, M, Abegglen, R, Akesson, C, Alba-Sanchez, F, Scott Anderson, R, Antipina, T, Atanassova, J, Beer, R, Belyanina, N, Blyakharchuk, T, Borisova, O, Bozilova, E, Bukreeva, G, Jane Bunting, M, Clo, E, Colombaroli, D, Combourieu-Nebout, N, Desprat, S, Di Rita, F, Djamali, M, Edwards, K, Fall, P, Feurdean, A, Fletcher, W, Florenzano, A, Furlanetto, G, Gaceur, E, Galimov, A, Galka, M, Garcia-Moreiras, I, Giesecke, T, Grindean, R, Guido, M, Gvozdeva, I, Herzschuh, U, Hjelle, K, Ivanov, S, Jahns, S, Jankovska, V, Jimenez-Moreno, G, Karpinska-Kolaczek, M, Kitaba, I, Kolaczek, P, Lapteva, E, Latalowa, M, Lebreton, V, Leroy, S, Leydet, M, Lopatina, D, Lopez-Saez, J, Lotter, A, Magri, D, Marinova, E, Matthias, I, Mavridou, A, Mercuri, A, Mesa-Fernandez, J, Mikishin, Y, Milecka, K, Montanari, C, Morales-Molino, C, Mrotzek, A, Sobrino, C, Naidina, O, Nakagawa, T, Nielsen, A, Novenko, E, Panajiotidis, S, Panova, N, Papadopoulou, M, Pardoe, H, Pedziszewska, A, Petrenko, T, Ramos-Roman, M, Ravazzi, C, Rosch, M, Ryabogina, N, Ruiz, S, Sakari Salonen, J, Sapelko, T, Schofield, J, Seppa, H, Shumilovskikh, L, Stivrins, N, Stojakowits, P, Svitavska, H, Swieta-Musznicka, J, Tantau, I, Tinner, W, Tobolski, K, Tonkov, S, Tsakiridou, M, Valsecchi, V, Zanina, O, Zimny, M, Davis B. A. S., Chevalier M., Sommer P., Carter V. A., Finsinger W., Mauri A., Phelps L. N., Zanon M., Abegglen R., Akesson C. M., Alba-Sanchez F., Scott Anderson R., Antipina T. G., Atanassova J. R., Beer R., Belyanina N. I., Blyakharchuk T. A., Borisova O. K., Bozilova E., Bukreeva G., Jane Bunting M., Clo E., Colombaroli D., Combourieu-Nebout N., Desprat S., Di Rita F., Djamali M., Edwards K. J., Fall P. L., Feurdean A., Fletcher W., Florenzano A., Furlanetto G., Gaceur E., Galimov A. T., Galka M., Garcia-Moreiras I., Giesecke T., Grindean R., Guido M. A., Gvozdeva I. G., Herzschuh U., Hjelle K. L., Ivanov S., Jahns S., Jankovska V., Jimenez-Moreno G., Karpinska-Kolaczek M., Kitaba I., Kolaczek P., Lapteva E. G., Latalowa M., Lebreton V., Leroy S., Leydet M., Lopatina D. A., Lopez-Saez J. A., Lotter A. F., Magri D., Marinova E., Matthias I., Mavridou A., Mercuri A. M., Mesa-Fernandez J. M., Mikishin Y. A., Milecka K., Montanari C., Morales-Molino C., Mrotzek A., Sobrino C. M., Naidina O. D., Nakagawa T., Nielsen A. B., Novenko E. Y., Panajiotidis S., Panova N. K., Papadopoulou M., Pardoe H. S., Pedziszewska A., Petrenko T. I., Ramos-Roman M. J., Ravazzi C., Rosch M., Ryabogina N., Ruiz S. S., Sakari Salonen J., Sapelko T. V., Schofield J. E., Seppa H., Shumilovskikh L., Stivrins N., Stojakowits P., Svitavska H. S., Swieta-Musznicka J., Tantau I., Tinner W., Tobolski K., Tonkov S., Tsakiridou M., Valsecchi V., Zanina O. G., and Zimny M.

Abstract

The Eurasian (née European) Modern Pollen Database (EMPD) was established in 2013 to provide a public database of high-quality modern pollen surface samples to help support studies of past climate, land cover, and land use using fossil pollen. The EMPD is part of, and complementary to, the European Pollen Database (EPD) which contains data on fossil pollen found in Late Quaternary sedimentary archives throughout the Eurasian region. The EPD is in turn part of the rapidly growing Neotoma database, which is now the primary home for global palaeoecological data. This paper describes version 2 of the EMPD in which the number of samples held in the database has been increased by 60 % from 4826 to 8134. Much of the improvement in data coverage has come from northern Asia, and the database has consequently been renamed the Eurasian Modern Pollen Database to reflect this geographical enlargement. The EMPD can be viewed online using a dedicated map-based viewer at https://empd2.github.io and downloaded in a variety of file formats at https://doi.pangaea.de/10.1594/PANGAEA.909130 (Chevalier et al., 2019).

Published
2020

11. Apport des analyses polliniques pour la reconstitution de l’histoire des climats, des paysages et des interactions homme/environnement sur les marges désertiques de la Tunisie méridionale depuis 6000 av. J.-C

Author

Jaouadi, S., LEBRETON, V., BOUSSOFFARA, R., Histoire naturelle de l'Homme préhistorique (HNHP), and Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS)-Université de Perpignan Via Domitia (UPVD)

Subjects
[SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2020

12. Sedimentary dynamic in a continental evaporitic environment (Palaeosekha Kasserine, Central Tunisia)

Author

Bkhairi, A., LEBRETON, V., Karray, M.R., Fouache, E., Histoire naturelle de l'Homme préhistorique (HNHP), and Muséum national d'Histoire naturelle (MNHN)-Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2020

14. Pollen transport and deposition in semi-arid and arid lands from North Africa

Author

Jaouadi, S., Lebreton, V., Jiménez Moreno, G., Hunt, C., Histoire naturelle de l'Homme préhistorique (HNHP), and Muséum national d'Histoire naturelle (MNHN)-Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2019

15. History of semi-arid and arid environments in the Eastern Maghreb during the Middle Holocene: first results of the pollen analysis from Sebkha Kelbia (Central Tunisia)

Author

Lebreton, V., Sahbi Jaouadi, Bruneau, M., Karbouch, M., Boujelben, A., Montaldi, M., F Berger, J., Histoire naturelle de l'Homme préhistorique (HNHP), and Muséum national d'Histoire naturelle (MNHN)-Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2019

16. Study of modern pollen from surficial lagoon sediments from the north-eastern of Tunisia

Author

GACEUR, E., Desprat, S., ROUIS-ZARGOUNI, I., Hanquiez, V., Lebreton, V., Combourieu-Nebout, N., Kallel, N., Histoire naturelle de l'Homme préhistorique (HNHP), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS)-Université de Perpignan Via Domitia (UPVD), and LSCE

Subjects
[SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

17. Middle Holocene climate changes and Capsian population dynamic in Central Tunisia during the 6th and 5th millennium BC

Author

Sahbi Jaouadi, Lebreton, V., Belhouchet, L., Mulazzani, S., Aouadi, N., Saafi, I., Nespoulet, R., Dunne, J., Evershed, R., Sghar, B., Histoire naturelle de l'Homme préhistorique (HNHP), Muséum national d'Histoire naturelle (MNHN)-Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS), and UISPP

Subjects
[SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

22. Holocene climate change and landscape evolution in the Mediterranean-Saharan transition area of Southern Tunisia

Author

Jaouadi, S., Lebreton, V., Viviane Bout-Roumazeilles, Siani, G., Lakhdar, R., Combourieu-Nebout, N., Histoire naturelle de l'Homme préhistorique (HNHP), and Muséum national d'Histoire naturelle (MNHN)-Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2016

23. New PPEs for key Mediterranean taxa

Author

Azuara, J., LEBRETON, V., MARQUER, L., Mazier, Florence, De Munnik, Nicolas, CUGNY, C., Combourieu-Nebout, N., Histoire naturelle de l'Homme préhistorique (HNHP), Muséum national d'Histoire naturelle (MNHN)-Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS), Géographie de l'environnement (GEODE), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J), and Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS)-Université de Perpignan Via Domitia (UPVD)

Subjects
[SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2016

24. Variation latitudinale de la végétation des domaines bioclimatiques semi-aride et aride à l’Holocène en Tunisie centrale et méridionale

Author

Lebreton, V., Sahbi Jaouadi, Histoire naturelle de l'Homme préhistorique (HNHP), and Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS)-Université de Perpignan Via Domitia (UPVD)

Subjects
[SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2016

25. New PPEs for key Mediterranean taxa and adaptation of the REVEALS model for lagoon's geometry

Author

Azuara, J., Mazier, Florence, LEBRETON, V., MARQUER, L., De Munnik, Nicolas, CUGNY, C., Combourieu-Nebout, N., Géographie de l'environnement (GEODE), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J), Histoire naturelle de l'Homme préhistorique (HNHP), Muséum national d'Histoire naturelle (MNHN)-Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS), and Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS)-Université de Perpignan Via Domitia (UPVD)

Subjects
[SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2016

29. Holocene paleoenvironmental changes in the Bay of Brest (NW France) over the last 6,500 years: palynological evidences of climate and human forcing

Author

Lambert, C., Penaud, A., Vidal, M., CHAUVAUD, L., Combourieu-Nebout, N., LEBRETON, V., Fernane, A., RAGUENEAU, O., VAN, VLIET, LANOE, B., Histoire naturelle de l'Homme préhistorique (HNHP), and Muséum national d'Histoire naturelle (MNHN)-Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2015

30. Early Neolithisation process in southwestern Ukraine: a view from the charcoal analysis

Author

SALAVERT, A., GOURIVEAU, E., LEBRETON, V., Messager, E., KIOSAK, D., Histoire naturelle de l'Homme préhistorique (HNHP), and Muséum national d'Histoire naturelle (MNHN)-Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2015

31. Enregistrement pollinique à haute résolution de la lagune El Bibane et implications pour l’étude de l’anthropisation des écosystèmes arides en Tunisie méridionale

Author

Jaouadi, S., LEBRETON, V., Combourieu-Nebout, N., Kallel, N., Dezileau, L., Histoire naturelle de l'Homme préhistorique (HNHP), and Muséum national d'Histoire naturelle (MNHN)-Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2015

32. Climatic influence and anthropogenic impact on Mediterranean vegetation during the late Holocene

Author

Azuara, J., Combourieu-Nebout, N., LEBRETON, V., Mazier, Florence, Dezileau, L., Histoire naturelle de l'Homme préhistorique (HNHP), Muséum national d'Histoire naturelle (MNHN)-Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS), Géographie de l'environnement (GEODE), and Université Toulouse - Jean Jaurès (UT2J)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2015

33. Holocene sedimentary records from playa lakes (sebkha) as palaeoecological archives in arid lands: potentialities and limits for pollen analyses in central and southern Tunisia (eastern Maghreb)

Author

Jaouadi, S., LEBRETON, V., Boujelben, A., Bkhairi, A., Karray, M.R., Histoire naturelle de l'Homme préhistorique (HNHP), and Muséum national d'Histoire naturelle (MNHN)-Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2015

36. Palaeolandscapes of Southern Apennines during the Early and Middle Pleistocene

Author

SANTANGELO, NICOLETTA, DI DONATO, VALENTINO, ROMANO, PAOLA, RUSSO ERMOLLI, ELDA, Lebreton V., Santangelo, Nicoletta, DI DONATO, Valentino, Lebreton, V., Romano, Paola, and RUSSO ERMOLLI, Elda

Subjects
Middle Pleistocene, Southern Apennine, Palaeogeography, hominin dispersal, Early Pleistocene, Palaeolithic
Abstract

A palaeolandscape reconstruction of the Southern Apennine chain for the Early and the Middle Pleistocene is presented with the main aim of highlighting the evolution of this sector of the chain during a key period for the diffusion of Palaeolithic men in the Italian peninsula. During the Calabrian stage Italy was an elongated peninsula, narrower than present, extended between the Tyrrhenian and the foreland seas with two big islands (Gargano and Murge) in the central part of the foredeep basin. This area started to emerge at the end of Early Pleistocene (1.2 - 0.78 Ma) when occasional communications among the islands and the Southern Apennine peninsula may have occurred, probably in concomitance with eustatic low stands. This scenario opens interesting questions on the migration pathways followed by ancient Palaeolithic men to reach the site of Pirro Nord (1.3-1.7 Ma; NW Gargano). The definitive emersion of the studied area was completed at the beginning of the Ionian stage when a lot of lakes punctuated the axial portion of the chain together with two great active volcanoes: Roccamonfina and Vulture. In the surroundings of the palaeo-lakes the Palaeolithic man started moving from 600 to 200 ka, as testified by the artefacts of Acheulean tradition recovered, among others, at Isernia La Pineta and Notarchirico.

Published
2012

38. L'industrie lithique de Ca' Belvedere di Monte Poggiolo: stratigraphie, matière première, typologie, remontages et traces d'utilisation

Author

Peretto, Carlo, Amore, F. O., Antoniazzi, Alberto, Antoniazzi, Aldo, Bahain, J. J., Cattani, L., Esposito, P., Falgueres, C., Gagnepain, J., Hedley, I., Laurent, M., Lebreton, V., Longo, L., Milliken, S., Monegatti, P., Olle', A., Pugliese, N., RENAULT MISKOVSKI, J., Sozzi, M., Ungaro, S., Vannucci, S., Verges, J. M., Wagner, J. J., and Yokoyama, Y.

Published
1998

44. Hominin responses to environmental changes during the Middle Pleistocene in Central and Southern Italy.

Author

Orain, R., Lebreton, V., Russo Ermolli, E., Sémah, A.-M., Nomade, S., Shao, Q., Bahain, J.-J., Hohenstein, U. Thun, and Peretto, C.

Abstract

The palaeobotanical record of early Palaeolithic sites from Western Europe indicates that hominins settled in different kinds of environments. During the ''Mid-Pleistocene Transition (MPT)'', from about 1 to 0.6 Ma, the transition from 41-ka to 100-ka dominant climatic oscillations, occurring within a long-term cooling trend, was associated with an aridity crisis which strongly modified the ecosystems. Starting from the MPT the more favorable climate of central and southern Italy provided propitious environmental conditions for long-term human occupations even during the glacial times. In fact, the human strategy of territory occupation was certainly driven by the availabilities of resources. Prehistoric sites such as Notarchirico (ca. 680-600 ka), La Pineta (ca. 600-620 ka), Gaudo San Nicola (ca. 380-350 ka) or Ceprano (ca. 345-355 ka) testify to a preferential occupation of the central and southern Apennines valleys during interglacial phases, while later interglacial occupations were oriented towards the coastal plains, as attested by the numerous settlements of the Roma basin (ca. 300 ka). Faunal remains indicate that human subsistence behaviors benefited of a diversity of exploitable ecosystems, from semi-open to closed environments. In central and southern Italy, several palynological records have already illustrated the regional and local scale vegetation dynamic trends. During the Middle Pleistocene climate cycles, mixed mesophytic forests developed during the interglacial periods and withdrew in response to increasing aridity during the glacial episodes. New pollen data from the Boiano basin (Molise, Italy), attest to the evolution of vegetation and climate between OIS 13 and 9 (ca. 500 to 300 ka). In this basin, the persistence of high edaphic humidity, even during the glacial phases, could have favored the establishment of a refuge area for the arboreal flora and provided subsistence resources for the animal and hominin communities during the Middle Pleistocene. This could have constrained human groups to migrate into such a propitious area. Regarding to the local climate evolution during the glacial episodes, the supposed displacement from these sites could be linked to the environmental dynamics solely due to the aridity increase rather than directly to the global climate changes. [ABSTRACT FROM AUTHOR]

Published
2012
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48. 3PC-003 Paediatric parenteral nutrition on weekends: who prepares? survey of country’s hospitals

Author

Lebreton, V, Blandeau, V, Olivier, E, and Thomaré, P

Abstract

BackgroundSince the March 2015 directive publication of the country’s health department, parenteral nutrition (PN) must be produced by hospital pharmacists, under pharmaceutical responsibility. How to manage closing periods of the hospital pharmacy unit (HPU) to manufacture individualised formulation of paediatric PN (IFPN) for newborns.PurposeSummarise the state of management of HPU closure for IFPN through a survey of hospitals in the country in 2017.Material and methodsA survey with oriented questions according to answers was developed. This form was sent by email to the hospital pharmacist.After general questions (Healthcare Establishment (HE) type: General Hospital Centre (GHC) or University Hospital Centre (UHC), maternity level (classed 1 to 3 in our country)), the first part approaches alternative solutions in case of no production during the HPU closing period. Then, the second part, for IFPN production, which answers different questions concerning formulation validation, production and controls.ResultsNineteen received responses were studied. For HE type: 17 UHC (89.5%) and two GHC (10.5%), all had a maternity (whose 95% with neonatal intensive care unit, level 3 (n=18)). Twelve of 17 pharmacists (65%) report no IFPN during the closing period. A major alternative solution is IFPN, which wereproduced before the closure period (e.g. on Friday). While 16% (n=2) of HE reported using only IFPN, 83.3% (n=10) use IFPN and standardised PN (SPN) and 25% (n=3) associated IFPN, SPN, and industrial PN (with or without supplementation).For other HE (35%, n=7) with PN activity on the weekend, 57.1% (n=4) produces IFPN at HPU and 42.9% (n=3) in the paediatric care unit. Only IFPN which were produced at HPU are formulations checked by a pharmacist. Then, for controls, everybody declared a double visual control during production, 71% realised analytics assays (mainly Na and K), 40% performed microbiologic assay and 60% (n=4) labelling check and mirage. Pharmaceutical liberation is reported on 80%.ConclusionThese results based on statements remain to be analysed cautiously but the trend is no production of IFPN on the weekend. In case of preparations, controls on final product allows the provision of a quality product for newborns. Compliance with the directive remains difficult, perhaps a consensus around SPN with paediatric physicians will make it possible to avoid PN production activity outside the opening period of HPU.References and/or AcknowledgementsPharmacists who had completed survey.No conflict of interest

Published
2018
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49. Approach to mining applications of computer-aided vision.

Author

Pampagnin L.H., Devy M., Lebreton V., Vialaret G., Pampagnin L.H., Devy M., Lebreton V., and Vialaret G.

Abstract

The use of automation and robotics in mining is discussed, with special emphasis on vision using visible and infrared radiation., The use of automation and robotics in mining is discussed, with special emphasis on vision using visible and infrared radiation.

50. 3PC-029 Calculation of annual economic impact of manufacturing avastin®syringes in the age-related macular degeneration treatment in our hospital

Author

Blandeau, V, Lebreton, V, Olivier, E, and Thomare, P

Abstract

BackgroundFollowing the obtaining of the Temporary Recommendation for Use (RTU) in 2015, Hospital Pharmacy Unit (HPU) manufactured syringes of Avastin®(bevacizumab) for treatment of age-related macular degeneration (AMD). Financial interest is significant, as cost of Avastin®is definitely lower than current drugs used for the same disease, and whose similar effectiveness has been demonstrated by several bibliographical studies.PurposeThe aim of the study is to determine the economic impact of this manufacturing of syringes by the HPU, from September 2016 to September 2017.Material and methodsAvastin 2.5 mg/0.1 mL syringes manufacturing requires material resources (isolator, syringes, needles, caps, flask of Avastin®100 mg/4 mL) and staff (pharmacy technicians). Cost calculation of annual production made it possible to estimate the benefits obtained using manufacturated syringes by the ophthalmology care unit in our hospital and by other healthcare establishments (HE). A comparison with the estimated cost of using the Lucentis®(ranibizumab) drug, which has Medicinal Market Authorisation (MMA) in this therapeutic indication, was carried out.ResultsThe HPU produced 39 batches yearly, in 1010 syringes, for a total cost of €15 251. Finally, 17.8% of syringes are used by the hospital and are refunded by social security (€100), and 39.8% of syringes are sold at other HE. Total annual gain is €14,648, while use of Lucentis®would allow an annual earning of €8451. Despite the losses (42.4%) due to a short expiry date, manufacturing Avastin®syringes compared with Lucentis®generates a higher gain, nearly €6,197€.ConclusionWith current consumption, this study shows that manufacturing of Avastin®syringes is financially promising in the treatment of AMD for our HPU, compared to the use of Lucentis®. Nevertheless, to optimise the profitability of Avastin syringes’ production, it would be interesting to correlate sessions’ productions with requests, thus improving production scheduling to decrease losses and increase earnings.No conflict of interest

Published
2018
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