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4. Club 35 Poster Session Wednesday 11 December: 11/12/2013, 09:30-16:00 * Location: Poster area

Author

Montoro Lopez, M., primary, Pons De Antonio, I., additional, Itziar Soto, C., additional, Florez Gomez, R., additional, Alonso Ladreda, A., additional, Rios Blanco, J., additional, Refoyo Salicio, E., additional, Moreno Yanguela, M., additional, Lopez Sendon, J., additional, Guzman Martinez, G., additional, Van De Heyning, C. M., additional, Magne, J., additional, Pierard, L., additional, Bruyere, P., additional, Davin, L., additional, De Maeyer, C., additional, Paelinck, B., additional, Vrints, C., additional, Lancellotti, P., additional, Michalski, B., additional, Krzeminska-Pakula, M., additional, Lipiec, P., additional, Szymczyk, E., additional, Chrzanowski, L., additional, Kasprzak, J., additional, Leao, R. N., additional, Florencio, A. F., additional, Oliveira, A. R., additional, Bento, B., additional, Lopes, S., additional, Calaca, J., additional, Palma Reis, R., additional, Krestjyaninov, M., additional, Gimaev, R., additional, Razin, V., additional, Arangalage, D., additional, Chiampan, A., additional, Cimadevilla, C., additional, Touati, A., additional, Himbert, D., additional, Brochet, E., additional, Iung, B., additional, Nataf, P., additional, Vahanian, A., additional, Messika-Zeitoun, D., additional, Guvenc, T., additional, Karacimen, D., additional, Erer, H., additional, Ilhan, E., additional, Sayar, N., additional, Karakus, G., additional, Eren, M., additional, Iriart, X., additional, Tafer, N., additional, Roubertie, F., additional, Mauriat, P., additional, Thambo, J., additional, Wang, J., additional, Fang, F., additional, Yip, G. W., additional, Sanderson, J., additional, Feng, W., additional, Yu, C., additional, Lam, Y., additional, Assabiny, A., additional, Apor, A., additional, Nagy, A., additional, Vago, H., additional, Toth, A., additional, Merkely, B., additional, Kovacs, A., additional, Castaldi, B., additional, Vida, V., additional, Guariento, A., additional, Padalino, M., additional, Cerutti, A., additional, Maschietto, N., additional, Biffanti, R., additional, Reffo, E., additional, Stellin, G., additional, Milanesi, O., additional, Baronaite-Dudoniene, K., additional, Urbaite, L., additional, Smalinskas, V., additional, Veisaite, R., additional, Vasylius, T., additional, Vaskelyte, J., additional, Puodziukynas, A., additional, Wieczorek, J., additional, Rybicka-Musialik, A., additional, Berger-Kucza, A., additional, Hoffmann, A., additional, Wnuk-Wojnar, A., additional, Mizia-Stec, K., additional, Melao, F., additional, Ribeiro, V., additional, Amorim, S., additional, Araujo, C., additional, Torres, J., additional, Cardoso, J., additional, Pinho, P., additional, Maciel, M., additional, Storsten, P., additional, Eriksen, M., additional, Boe, E., additional, Estensen, M., additional, Erikssen, G., additional, Smiseth, O., additional, Skulstad, H., additional, Miglioranza, M., additional, Gargani, L., additional, Sant`Anna, R., additional, Rover, M., additional, Martins, V., additional, Mantovanni, A., additional, Kalil, R., additional, Leiria, T., additional, Luo, X., additional, Lee, P., additional, Zhang, Z., additional, Kwong, J. S., additional, Borowiec, A., additional, Dabrowski, R., additional, Wozniak, J., additional, Jasek, S., additional, Chwyczko, T., additional, Kowalik, I., additional, Janas, J., additional, Musiej-Nowakowska, E., additional, Szwed, H., additional, Palinsky, M., additional, Petrovicova, J., additional, Pirscova, M., additional, Baricevic, Z., additional, Lovric, D., additional, Cikes, M., additional, Skoric, B., additional, Ljubas Macek, J., additional, Reskovic Luksic, V., additional, Separovic Hanzevacki, J., additional, Milicic, D., additional, Elmissiri, A., additional, El Shahid, G., additional, Abdal-Wahhab, S., additional, Vural, M. G., additional, Yilmaz, M., additional, Cetin, S., additional, Akdemir, R., additional, Yoldas, T. K., additional, Yeter, E., additional, Karamanou, A., additional, Hamodraka, E., additional, Lekakis, I., additional, Paraskevaidis, I., additional, Kremastinos, D., additional, Appiah-Dwomoh, E. K., additional, Wang, V., additional, Otto, C., additional, Mayar, F., additional, Bonaventura, K., additional, Sunman, H., additional, Canpolat, U., additional, Kuyumcu, M., additional, Yorgun, H., additional, Sahiner, L., additional, and Ozer, N., additional

Published
2013
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9. Club 35 Poster Session Wednesday 11 December: 11/12/2013, 09:30-16:00 * Location: Poster area

Author

Montoro Lopez, M, Pons De Antonio, I, Itziar Soto, C, Florez Gomez, R, Alonso Ladreda, A, Rios Blanco, JJ, Refoyo Salicio, E, Moreno Yanguela, M, Lopez Sendon, JL, Guzman Martinez, G, Van De Heyning, C M, Magne, J, Pierard, LA, Bruyere, PJ, Davin, L, De Maeyer, C, Paelinck, BP, Vrints, CJ, Lancellotti, P, Michalski, BW, Krzeminska-Pakula, M, Lipiec, P, Szymczyk, E, Chrzanowski, L, Kasprzak, JD, Leao, R N, Florencio, A F, Oliveira, A R, Bento, B, Lopes, S, Calaca, J, Palma Reis, R, Krestjyaninov, MV, Gimaev, RH, Razin, VA, Arangalage, D, Chiampan, A, Cimadevilla, C, Touati, A, Himbert, D, Brochet, E, Iung, B, Nataf, P, Vahanian, A, Messika-Zeitoun, D, Guvenc, TS, Karacimen, D, Erer, HB, Ilhan, E, Sayar, N, Karakus, G, Eren, M, Iriart, X, Tafer, N, Roubertie, F, Mauriat, P, Thambo, JB, Wang, J, Fang, F, Yip, G WK, Sanderson, J, Feng, W, Yu, CM, Lam, YY, Assabiny, A, Apor, A, Nagy, A, Vago, H, Toth, A, Merkely, B, Kovacs, A, Castaldi, B, Vida, VL, Guariento, A, Padalino, M, Cerutti, A, Maschietto, N, Biffanti, R, Reffo, E, Stellin, G, Milanesi, O, Baronaite-Dudoniene, K, Urbaite, L, Smalinskas, V, Veisaite, R, Vasylius, T, Vaskelyte, J, Puodziukynas, A, Wieczorek, J, Rybicka-Musialik, A, Berger-Kucza, A, Hoffmann, A, Wnuk-Wojnar, A, Mizia-Stec, K, Melao, F, Ribeiro, V, Amorim, S, Araujo, C, Torres, JP, Cardoso, JS, Pinho, P, Maciel, MJ, Storsten, P, Eriksen, M, Boe, E, Estensen, ME, Erikssen, G, Smiseth, OA, Skulstad, H, Miglioranza, MH, Gargani, L, Sant`Anna, RT, Rover, M, Martins, VM, Mantovanni, A, Kalil, RK, Leiria, TL, Luo, XX, Fang, F, Lee, PW, Zhang, ZH, Lam, YY, Sanderson, JE, Kwong, J SW, Yu, CM, Borowiec, A, Dabrowski, R, Wozniak, J, Jasek, S, Chwyczko, T, Kowalik, I, Janas, J, Musiej-Nowakowska, E, Szwed, H, Palinsky, M, Petrovicova, J, Pirscova, M, Baricevic, Z, Lovric, D, Cikes, M, Skoric, B, Ljubas Macek, J, Reskovic Luksic, V, Separovic Hanzevacki, J, Milicic, D, Elmissiri, AM, El Shahid, GS, Abdal-Wahhab, S, Vural, M G, Yilmaz, M, Cetin, S, Akdemir, R, Yoldas, T K, Yeter, E, Karamanou, AG, Hamodraka, ES, Lekakis, IA, Paraskevaidis, IA, Kremastinos, DT, Appiah-Dwomoh, E K, Wang, VC, Otto, C, Mayar, F, Bonaventura, K, Sunman, H, Canpolat, U, Kuyumcu, M, Yorgun, H, Sahiner, L, and Ozer, N

Abstract

Purpose: It is known the higher prevalence of structural heart disease in HIV patients, mostly diastolic dysfunction and pulmonary hypertension. In spite of that, there are few data about predisposing factors. Our objective was to evaluate whether HIV stage or detectable blood viral load correlate with the degree of heart disease. Methods: We conducted a prospective cohort study with HIV patients monitored by the internal medicine unit of our institution. We selected symptomatic patients with functional class ≥ II of NYHA scale. Viral blood load and CD4 count were systematically determined in order to obtain the HIV stage. Patients underwent a transthoracic echocardiogram to assess ventricular hypertrophy, systolic and diastolic dysfunction and pulmonary hypertension, according to the limits set by ESC guidelines. Results: Data were obtained from 65 HIV patients with dyspnea (63% male) with a mean age of 48 years. 50% were in NYHA grade II, 32.3% III and 17.7% IV. 46.7% of patients had some data of structural heart disease (figure). Belong to AIDS group (65.3%) did not correlate with the degree of heart disease. However, patients with positive blood viral load had a significantly higher incidence of structural heart disease than those with undetectable load (75% vs. 43% p <0.04), independent of their cardiovascular risk profile or type of antiretroviral therapy (Table). Conclusion: In our experience, half of HIV patients with dyspnea show echocardiographic data of structural heart disease. Detectable viral load in blood doubles the prevalence of heart disease, so that HIV itself may be an independent causal agent. These data should be taken into account in the screening of structural heart disease in these patients. Figure Prevalence of structural heart disease

Published
2013
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10. Strength-duration relationship for intra- versus extracellular stimulation with microelectrodes.

Author

Rattay F, Paredes LP, and Leao RN

Subjects
Animals, Electric Stimulation methods, Hippocampus physiology, Mice, Mice, Inbred C57BL, Time Factors, Chronaxy physiology, Extracellular Fluid physiology, Intracellular Fluid physiology, Membrane Potentials physiology, Microelectrodes
Abstract

Chronaxie, a historically introduced excitability time parameter for electrical stimulation, has been assumed to be closely related to the time constant of the cell membrane. Therefore, it is perplexing that significantly larger chronaxies have been found for intracellular than for extracellular stimulation. Using compartmental model analysis, this controversy is explained on the basis that extracellular stimulation also generates hyperpolarized regions of the cell membrane hindering a steady excitation as seen in the intracellular case. The largest inside/outside chronaxie ratio for microelectrode stimulation is found in close vicinity of the cell. In the case of monophasic cathodic stimulation, the length of the primarily excited zone which is situated between the hyperpolarized regions increases with electrode-cell distance. For distant electrodes this results in an excitation process comparable to the temporal behavior of intracellular stimulation. Chronaxie also varies along the neural axis, being small for electrode positions at the nodes of Ranvier and axon initial segment and larger at the soma and dendrites. As spike initiation site can change for short and long pulses, in some cases strength-duration curves have a bimodal shape, and thus, they deviate from a classical monotonic curve as described by the formulas of Lapicque or Weiss., (Copyright © 2012 IBRO. Published by Elsevier Ltd. All rights reserved.)

Published
2012
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