1. Benefits of High-Intensity Exercise Training to Patients with Chronic Obstructive Pulmonary Disease: A Controlled Study
- Author
-
Björn Beutel, Tobias Boeselt, Timm Greulich, Klaus Kenn, A. Rembert Koczulla, S. Apelt, Martina Veith, Christoph Nell, Marc Spielmanns, Lea Lütteken, K Kehr, Sabina Janciauskiene, Janine Koepke, Peter Alter, and Claus Vogelmeier
- Subjects
Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Strength exercise ,Pulmonary disease ,macromolecular substances ,030204 cardiovascular system & hematology ,Quadriceps Muscle ,Pulmonary function testing ,Pulmonary Disease, Chronic Obstructive ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,medicine ,Humans ,Aged ,COPD ,business.industry ,High intensity ,Exercise therapy ,Middle Aged ,medicine.disease ,Exercise Therapy ,respiratory tract diseases ,030228 respiratory system ,Exercise Test ,Quality of Life ,Physical therapy ,Female ,business ,Biomarkers - Abstract
Background: Various exercise training programs are used for patients with chronic obstructive pulmonary disease (COPD) of different severity. Objectives: To investigate the impact of individualized high-intensity training on exercise capacity with COPD. Methods: A total of 49 patients agreed to participate. Of these, 31 were assigned to the training group and 18 served as controls. The training group exercised twice a week for 90 min with consecutively increasing loads. At the time of enrollment (T0), as well as after 3 (T1) and 6 (T2) months, a 6-min walk test (6-MWT) was performed and data on health-related quality of life, femoral muscle thickness, and various serum markers were obtained. Results: The training group improved in their 6-MWT results (T0 = 407 ± 152 m vs. T1 = 459 ± 127 m, p = 0.002, vs. T2 = 483.2 ± 130.1 m, p = 0.004), in their cross-sectional area of the musculus rectus femoris (T0 = 6.2 ± 1.2 cm2 vs. T1 = 6.9 ± 1.2 cm2, p = 0.003, vs. 7.5 ± 1.6 cm2, p = 0.002), and in their St. George's Respiratory Questionnaire (SGRQ) score (T0 = 43.3 ± 18.0 vs. T1 = 36.0 ± 18.4, p = 0.001, vs. T2 = 34.7 ± 18. 0, p = 0.004). Serum levels of myostatin, irisin, resistin, and α-Klotho did not change significantly within the training period. Of note, the exercise group showed an inverse relationship between serum levels of resistin and those of α-Klotho after 6 months (r = -0.608, p = 0.021). Conclusions: COPD patients undergoing an individualized, structured, high-intensity training program improved their exercise capacity, gained muscle mass, and improved their quality of life.
- Published
- 2017