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Your search keyword '"Lea, Vivienne"' showing total 27 results
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27 results on '"Lea, Vivienne"'

1. Incidence and potential prognostic implications of fibroblast growth factor receptor gene alterations and coexisting mutations in colorectal cancer.

Author

Lea, Vivienne, primary, Lim, Stephanie Hui-Su, additional, Chua, Wei, additional, Ng, Weng Leong, additional, Wang, Bin, additional, Wilkinson, Kate Jessica, additional, Farzin, Mahtab, additional, Habashy, Paul, additional, Roberts, Tara, additional, Becker, Therese, additional, and Lee, Cheok Soon, additional

Published
2024
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2. Microsatellite Instability Testing and Prognostic Implications in Colorectal Cancer

Author

Ho, Vincent, primary, Chung, Liping, additional, Wilkinson, Kate, additional, Ma, Yafeng, additional, Rutland, Tristan, additional, Lea, Vivienne, additional, Lim, Stephanie H., additional, Abubakar, Askar, additional, Ng, Weng, additional, Lee, Mark, additional, Roberts, Tara L., additional, Becker, Therese M., additional, Mackenzie, Scott, additional, Chua, Wei, additional, and Lee, Cheok Soon, additional

Published
2024
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3. KRAS and BRAF Mutation Rates and Survival Outcomes in Colorectal Cancer in an Ethnically Diverse Patient Cohort

Author

Habashy, Paul, primary, Lea, Vivienne, additional, Wilkinson, Kate, additional, Wang, Bin, additional, Wu, Xiao-Juan, additional, Roberts, Tara Laurine, additional, Ng, Weng, additional, Rutland, Tristan, additional, Po, Joseph William, additional, Becker, Therese, additional, Descallar, Joseph, additional, Lee, Mark, additional, Mackenzie, Scott, additional, Gupta, Ruta, additional, Cooper, Wendy, additional, Lim, Stephanie, additional, Chua, Wei, additional, and Lee, Cheok Soon, additional

Published
2023
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4. Multigene panel next generation sequencing in metastatic colorectal cancer in an Australian population

Author

Nindra, Udit, primary, Pal, Abhijit, additional, Lea, Vivienne, additional, Lim, Stephanie Hui-Su, additional, Wilkinson, Kate, additional, Asghari, Ray, additional, Roberts, Tara L., additional, Becker, Therese M., additional, Farzin, Mahtab, additional, Rutland, Tristan, additional, Lee, Mark, additional, MacKenzie, Scott, additional, Ng, Weng, additional, Wang, Bin, additional, Lee, C. Soon, additional, and Chua, Wei, additional

Published
2023
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5. Utility of multigene panel next‐generation sequencing in routine clinical practice for identifying genomic alterations in newly diagnosed metastatic nonsmall cell lung cancer

Author

Nindra, Udit, primary, Pal, Abhijit, additional, Bray, Victoria, additional, Yip, Po Y., additional, Tognela, Annette, additional, Roberts, Tara L., additional, Becker, Therese M., additional, Williamson, Jonathon, additional, Farzin, Mahtab, additional, Li, Jing J., additional, Lea, Vivienne, additional, Hagelamin, Abeer, additional, Ng, Weng, additional, Wang, Bin, additional, Lee, C. Soon, additional, and Chua, Wei, additional

Published
2023
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7. Utility of multigene panel next‐generation sequencing in routine clinical practice for identifying genomic alterations in newly diagnosed metastatic nonsmall cell lung cancer.

Author

Nindra, Udit, Pal, Abhijit, Bray, Victoria, Yip, Po Y., Tognela, Annette, Roberts, Tara L., Becker, Therese M., Williamson, Jonathon, Farzin, Mahtab, Li, Jing J., Lea, Vivienne, Hagelamin, Abeer, Ng, Weng, Wang, Bin, Lee, C. Soon, and Chua, Wei

Subjects
STATISTICAL correlation, PROFESSIONAL practice, GENOMICS, EARLY detection of cancer, RETROSPECTIVE studies, DNA, DESCRIPTIVE statistics, DISEASE prevalence, METASTASIS, AGE factors in disease, IMMUNOHISTOCHEMISTRY, GENE expression profiling, RESEARCH, ONCOGENES, LUNG cancer, GENETIC mutation, COMPARATIVE studies, GENETIC profile, SEQUENCE analysis, EPIDERMAL growth factor receptors, MEMBRANE proteins
Abstract

Background: The standard of care in newly diagnosed metastatic non‐small cell lung cancer (NSCLC) is to test for aberrations in three genes for driver mutations – ALK, ROS1 and epidermal growth factor receptor (EGFR) – and also for immunohistochemistry to be performed for programmed death‐ligand 1 expression level. Next‐generation sequencing (NGS), with or without RNA fusion testing, is increasingly used in standard clinical practice to identify patients with potentially actionable mutations. Stratification of NGS mutation tiers is currently based on the European Society of Medical Oncology Scale for Clinical Actionability of Molecular Targets (ESCAT) Tiers I–V and X. Aim: Our aim was to analyse NSCLC tumour samples for the prevalence of Tiers I–V mutations to establish guidance for current and novel treatments in patients with metastatic disease. Methods: NGS was performed employing the Oncomine Precision Assay (without RNA fusion testing) that interrogates DNA hotspot variants across 45 genes to screen 210 NSCLC tissue samples obtained across six Sydney hospitals between June 2021 and March 2022. Results: In our cohort, 161 of 210 (77%) had at least one gene mutation identified, with 41 of 210 (20%) having two or more concurrent mutations. Tier I mutations included 42 of 210 (20%) EGFR mutations (EIA) and five of 210 (3%) MET exon 14 skipping mutations (EIB). Non‐Tier I variants included 22 of 210 (11%) KRAS G12C hotspot mutations (EIIB), with a further 47 of 210 (22%) having non‐G12C KRAS (EX) mutations. NGS testing revealed an additional 15% of cases with Tier II ESCAT mutations in NSCLC. Forty‐six percent of patients also demonstrated potential Tier III and IV mutations that are currently under investigation in early‐phase clinical trials. Conclusions: In addition to identifying patients with genomic alterations suitable for clinically proven standard‐of‐care therapeutic options, the 45‐gene NGS panel has significant potential in identifying potentially actionable non‐Tier 1 mutations that may become future standard clinical practice in NSCLC. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Complications of psoriasis: clinicopathology, screening, and management.

Author

Tran, Michael, Lea, Vivienne, and Wong, Li-Chuen

Subjects
PSORIATIC arthritis, ORAL medication, MEDICAL screening, BIOTHERAPY, PSORIASIS, CLINICAL pathology, MEDICAL personnel
Abstract

Psoriasis is a chronic inflammatory disease that affects up to 3% of the population. Patients with psoriasis are at increased risk of developing complications such as arthritis, cardiovascular disease, diabetes, and depression. However, screening for these complications is often not done in up to 60% of patients. The National Institute for Health and Care Excellence (NICE) recommends annual assessment for psoriatic arthritis and screening for physical, psychological, and social wellbeing. Other complications of psoriasis include metabolic syndrome and mental health disorders. Early identification and treatment of these complications are important to prevent irreversible damage. A multidisciplinary team approach involving healthcare providers from various specialties is recommended for the management of psoriasis. [Extracted from the article]

Published
2024
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17. Additional file 1: of Overexpression of the MRE11-RAD50-NBS1 (MRN) complex in rectal cancer correlates with poor response to neoadjuvant radiotherapy and prognosis

Author

Ho, Vincent, Liping Chung, Amandeep Singh, Lea, Vivienne, Abubakar, Askar, Lim, Stephanie, Weng Ng, Lee, Mark, Souza, Paul De, Joo-Shik Shin, and Cheok Lee

Subjects
enzymes and coenzymes (carbohydrates)
Abstract

Figure S1. Survival outcomes in relation to MRE11 and NBS1 protein expression in rectal cancer tissues. Kaplan-Meier analysis was performed to measure the overall survival (OS) for high (red line) vs. low (blue line) MRE11, NBS1 protein expression in patients with rectal cancer. (A-D) Comparison of survival curves according to histological grade between MRE11 in low-grade (A, G1–2, n = 230) and high-grade (B, G3, n = 19) subgroups; NBS1 in low vs. high grade (C, D) subgroups, respectively. (PDF 163 kb)

Published
2018
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