5 results on '"LeMestre, Soizic"'
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2. Accelerating clinical trial implementation in the context of the COVID-19 pandemic: challenges, lessons learned and recommendations from DisCoVeRy and the EU-SolidAct EU response group
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Diallo, Alpha Troseid, Marius Simensen, Victoria Charlotte and Boston, Anais Demotes, Jacques Olsen, Inge Christoffer and Chung, Florence Paiva, Jose Artur Hites, Maya Ader, Florence and Arribas, Jose Ramon Baratt-Due, Andreas Melien, Oyvind and Tacconelli, Evelina Staub, Therese Greil, Richard Tsiodras, Sotirios Briel, Matthias Esperou, Helene Mentre, France and Eustace, Joe Saillard, Juliette Delmas, Christelle LeMestre, Soizic Dumousseaux, Marina Costagliola, Dominique Rottingen, John-Arne Yazdanpanah, Yazdan EU-Response Investigators Grp
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- 2022
3. Accelerating clinical trial implementation in the context of the COVID-19 pandemic: challenges, lessons learned and recommendations from DisCoVeRy and the EU-SolidAct EU response group
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Diallo, Alpha, primary, Trøseid, Marius, additional, Simensen, Victoria Charlotte, additional, Boston, Anaïs, additional, Demotes, Jacques, additional, Olsen, Inge Christoffer, additional, Chung, Florence, additional, Paiva, José Artur, additional, Hites, Maya, additional, Ader, Florence, additional, Arribas, Jose Ramon, additional, Baratt-Due, Andreas, additional, Melien, Øyvind, additional, Tacconelli, Evelina, additional, Staub, Thèrèse, additional, Greil, Richard, additional, Tsiodras, Sotirios, additional, Briel, Matthias, additional, Esperou, Hélène, additional, Mentré, France, additional, Eustace, Joe, additional, Saillard, Juliette, additional, Delmas, Christelle, additional, LeMestre, Soizic, additional, Dumousseaux, Marina, additional, Costagliola, Dominique, additional, Røttingen, John-Arne, additional, and Yazdanpanah, Yazdan, additional
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- 2022
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4. High-risk exposure without personal protective equipment and infection with SARS-CoV-2 in-hospital workers - The CoV-CONTACT cohort
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Tubiana, Sarah, Burdet, Charles, Houhou, Nadhira, Thy, Michael, Manchon, Pauline, Blanquart, François, Charpentier, Charlotte, Guedj, Jérémie, Alavoine, Loubna, Behillil, Sylvie, Leclercq, Anne, Lucet, Jean-Christophe, Yazdanpanah, Yazdan, Attia, Mikaël, Demeret, Caroline, Rose, Thierry, Bielicki, Julia Anna, Bruijning-Verhagen, Patricia, Goossens, Herman, Descamps, Diane, van der Werf, Sylvie, Lina, Bruno, Duval, Xavier, Abad, Fanny, Abry, Dominique, Allain, Jean-Sébastien, Amiel-Taieb, Karline, Audoin, Pierre, Augustin, Shana, Ayala, Sandrine, Bansard, Hélène, Bertholon, Fréderique, Boissel, Nolwenn, Botelho-Nevers, Elisabeth, Bouiller, Kévin, Bourgeon, Marilou, Boutrou, Mathilde, Brick, Lysiane, Bruneau, Léa, Caumes, Eric, Chabouis, Agnès, Chan Thien, Eric, Chirouze, Catherine, Coignard, Bruno, Costa, Yolande, Costenoble, Virginie, Cour, Sylvie, Cracowski, Claire, Cracowski Jean, Luc, Deplanque, Dominique, Dequand, Stéphane, Desille-Dugast, Mireille, Desmarets, Maxime, Detoc, Maelle, Dewitte, Marie, Djossou, Felix, Ecobichon, Jean-Luc, Elrezzi, Elise, Faurous, William, Fortuna, Viviane, Fouchard, Julie, Gantier, Emilie, Gautier, Céline, Gerardin, Patrick, Gerset, Sandrine, Gilbert, Marie, Gissot, Valérie, Guillemin, Francis, Hartard, Cédric, Hazevis, Béatrice, Hocquet, Didier, Hodaj, Enkelejda, Ilic-Habensus, Emila, A, Jeudy, Jeulin, Helene, Kane, Maty, Kasprzyk, Emmanuelle, Kikoine, John, Laine, Fabrice, Laviolle, Bruno, Lebeaux, David, Ledru, Eric, Lefevre, Benjamin, Legoas, Carole, Legrand, Amélie, Legrand, Karine, Lehacaut, Jonathan, Lehur, Claire, Lemouche, Dalila, Lepiller, Quentin, Lepuil, Sévérine, Letienne, Estelle, Lucarelli, Aude, Madeline, Isabelle, Maillot, Adrien, Malapate, Catherine, Malvy, Denis, Mandic, Milica, Marty-Quinternet, Solène, Meghadecha, Mohamed, Mergeay-Fabre, Mayka, Mespoulhe, Pauline, Meunier, Alexandre, Migaud, Maria-Claire, Motiejunaite, Justina, Nathalie, Gay, Nguyen, Duc, Oubbea, Soumaya, Pagadoy, Maïder, Paris, Adeline, Paris, Christophe, Payet, Christine, Peiffer-Smadja, Nathan, Perez, Lucas, Perreau, Pauline, Pierrez, Nathalie, Pistone, Thierry, Postolache, Andreea, Rasoamanana, Patrick, Reminiac, Cécile, Rexah, Jade, Roche-Gouanvic, Elise, Rousseau, Alexandra, Schoemaecker, Betty, Simon, Sandrine, Soler, Catherine, Somers, Stéphanie, Sow, Khaly, Tardy, Bernard, Terzian, Zaven, Tournier, Anne, Tyrode, Sandrine, Vauchy, Charline, Verdon, Renaud, Vernet, Pauline, Vignali, Valérie, Waucquier, Nawal, Do Thi Thu, Huong, Laouénan, Cédric, Mentre, France, Pauline, Manchon, Dechanet, Aline, Letrou, Sophie, Quintin, Caroline, Frezouls, Wahiba, Le Hingrat, Quentin, Damond, Florence, Descamps, Dianes, Visseaux, Benoit, Vabret, Astrid, Bouscambert, Maud, Gaillanne, Laurence, Benmalek, Nabil, Attia, Mikael, Barbet, Marion, Petres, Stéphane, Escriou, Nicolas, Goyard, Sophie, Kafif, Ouifiya, Piquard, Valentine, Mailles, Alexandra, Simondon, Anne, Dreyere, Marion, Morel, Bruno, Vesval, Thiphaine, Amat, Karine, Ammour, Douae, Aqourras, Khadija, Couffin-Cadiergues, Sandrine, Delmas, Christelle, Desan, Vristi, Jean, Michel Doute, Esperou, Hélène, Hendou, Samia, Kouakam, Christelle, Le Meut, Guillaume, Lemestre, Soizic, Leturque, Nicolas, Marcoul, Emmanuelle, Nguefang, Solange, Roufai, Layidé, Abel, Laurent, Caillat-Zucman, Sophie, Study Group, Covcontact, Centre d'investigation Clinique [CHU Bichat] - Épidémiologie clinique (CIC 1425), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre interdisciplinaire de recherche en biologie (CIRB), Labex MemoLife, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses (GMV-ARN (UMR_3569 / U-Pasteur_2)), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Centre National de Référence des virus des infections respiratoires (dont la grippe) - National Reference Center Virus Influenzae [Paris] (CNR - laboratoire coordonnateur), Institut Pasteur [Paris] (IP), Hôpital Beaujon [AP-HP], Physique des fonctions biologiques / Physics of Biological Functions, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Biologie Cellulaire des Lymphocytes - Lymphocyte Cell Biology, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), St George's, University of London, University Children’s Hospital Basel = Hôpital pédiatrique universitaire des deux Bâle [Bâle, Suisse] (UKBB), University Medical Center [Utrecht], Universiteit Antwerpen = University of Antwerpen [Antwerpen], Virology and human respiratory Pathologies - Virology and human respiratory Pathologies (VirPath), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de Référence des Virus des Infections Respiratoires (dont la Grippe) [Lyon] (CNR - laboratoire associé), Institut des Agents Infectieux [Lyon] (IAI), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), CHU Pontchaillou [Rennes], Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), ANR-20-COVI-0002,CORaDiag,COVID 19 Rapid diagnosis test (development and clinical validation in 7 weeks)(2020), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Microbiology (medical) ,medicine.medical_specialty ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,Health Personnel ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,[SDV]Life Sciences [q-bio] ,Pneumonia, Viral ,Sars-cov-2 ,Betacoronavirus ,03 medical and health sciences ,Health personnel ,0302 clinical medicine ,High-risk exposure ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Personal protective equipment ,medicine ,Humans ,Risk exposure ,Transmission ,030212 general & internal medicine ,Letter to the Editor ,Pandemics ,ComputingMilieux_MISCELLANEOUS ,0303 health sciences ,030306 microbiology ,Transmission (medicine) ,business.industry ,COVID-19 ,3. Good health ,Infectious Diseases ,Cohort ,Emergency medicine ,In-hospital workers ,Human medicine ,Coronavirus Infections ,business - Abstract
International audience
- Published
- 2021
- Full Text
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5. Detection of SARS-CoV-2 N-antigen in blood during acute COVID-19 provides a sensitive new marker and new testing alternatives
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Marcoul Emmanuelle, Benoit Visseaux, Minh Patrick Lê, Alphonsine Diouf, Mergeay-Fabre Mayka, Kasprzyk Emmanuelle, Hazevis Beatrice, Houhou Nadhira, Christophe Choquet, Laviolle Bruno, Benedicte Rossignol, Verdon Renaud, Aqourras Khadija, Bourgeon Marilou, Lehur Claire, Ikram Houas, Ventzislava Petrov-Sanchez, Jeremie Guedj, Aurelie Veislinger, Amina Meziane, Brick Lysiane, Salma Jaafoura, Alexandre Hoctin, Visseaux Benoit, Oriane Puéchal, Alavoine Loubna, Denis Malvy, Gautier Celine, Letienne Estelle, Djossou Felix, Amiel-Taieb Karline, Esperou Helene, Thy Michael, Alpha Diallo, Bertholon Frederique, Sow Khaly, Boutrou Mathilde, Somers Stephanie, Tardy Bernard, Descamps Dianes, Rose Thierry, Morgane Gilg, Lucarelli Aude, Kikoine John, Charles Burdet, Barbet Marion, Kafif Ouifiya, Yazdan Yazdanpanah, Perez Lucas, Justine Pages, Laurent Abel, Florence Damond, Kouakam Christelle, Guillemin Francis, Dominique Deplanque, Marie Pierre Debray, Camille Couffignal, Botelho-Nevers Elisabeth, Jean Sebastien Hulot, Desmarets Maxime, Meunier Alexandre, Legrand Amelie, Maillot Adrien, Marine Beluze, Hartard Cedric, Bansard Helene, Legoas Carole, Gantier Emilie, Ledru Eric, Noemie Mercier, Sylvie van der Werf, Philippine Eloy, Guillaume Lingas, Coralie Tardivon, Fouchard Julie, Dewitte Marie, Bruno Lina, Alexandra Coelho, Boissel Nolwenn, Demeret Caroline, Marty-Quinternet Solene, Cédric Laouénan, Nassima Si Mohammed, Meghadecha Mohamed, Reminiac Cecile, Isabelle Gorenne, Chabouis Agnes, Paris Adeline, Sabrina Kali, Pierrez Nathalie, Mathilde Desvallee, Cracowski Jean Luc, Nathan Peiffer-Smadja, Tournier Anne, Abry Dominique, Marina Esposito-Farese, Lucet Jean-Christophe, Tristan Gigante, Abad Fanny, Olivier Picone, Lefevre Benjamin, Soizic Le Mestre, Ecobichon Jean-Luc, Manuel Rosa-Calatrava, Morel Bruno, Leturque Nicolas, Nguyen Duc, Nathalie Gault, Simon Sandrine, Jade Ghosn, Letrou Sophie, Elrezzi Elise, Ilic-Habensus Emila, Hodaj Enkelejda, Quintin Caroline, Doute Jean Michel, Schoemaecker Betty, Escriou Nicolas, Francois Dubos, A. Jeudy, Gilles Peytavin, Nadhira Houhou-Fidouh, Aurelie Papadopoulos, Noemie Vanel, Aurélie Wiedemann, Vincent Enouf, Rasoamanana Patrick, Behillil Sylvie, Le Hingrat Quentin, Vernet Pauline, Eric D'Ortenzio, Couffin-Cadiergues Sandrine, Damond Florence, Rousseau Alexandra, Jimmy Mullaert, Lemestre Soizic, Cracowski Claire, Malapate Catherine, Hocquet Didier, Francois Teoule, Hervé Le Nagard, Krishna Bhavsar, Mandic Milica, Postolache Andreea, Yves Levy, Caroline Semaille, Perreau Pauline, Frezouls Wahiba, Malvy Denis, Bouscambert Maud, Nadège Néant, Soler Catherine, Dreyere Marion, Nabil Benmalek, Diane Descamps, Allain Jean-Sebastien, Gerardin Patrick, Lila Bouadma, Charlotte Charpentier, Roufai Layide, Caillat-Zucman Sophie, Sandrine Couffin-Cardiergues, Sylvie Behilill, François Angoulvant, Coignard Bruno, Marina Mambert, Petres Stephane, Jean-François Timsit, Dehbia Benkerrou, Coralie Khan, Goyard Sophie, Motiejunaite Justina, Le Meut Guillaume, Burdet Charles, Christelle Paul, Catherine Chirouze, Pagadoy Maider, Hugo Mouquet, Hendou Samia, Fortuna Viviane, Dechanet Aline, Claire Andrejak, Marion Schneider, Claire Levy-Marchal, Christelle Tual, Olivier Terrier, Gerset Sandrine, J.-C. Lucet, Ammour Douae, Quentin Le Hingrat, Madeline Isabelle, Piquard Valentine, Costenoble Virginie, Paris Christophe, Lepiller Quentin, Manuel Etienne, Vignali Valerie, Oubbea Soumaya, Kane Maty, Hélène Espérou, François-Xavier Lescure, Desan Vristi, Vauchy Charline, Francois Bompart, Simondon Anne, Xavier Duval, Delphine Bachelet, Tyrode Sandrine, Rexah Jade, Bruneau Lea, Carine Roy, Gilbert Marie, Amat Karine, Augustin Shana, Gissot Valerie, Lehacaut Jonathan, Do Thi Thu Huong, Antoine Khalil, Marie Capucine Tellier, Pauline Manchon, Ouifiya Kafif, Bouiller Kevin, Jeulin Helene, Faurous William, Tubiana Sarah, Cour Sylvie, Detoc Maelle, Van Der Werf Sylvie, Mailles Alexandra, Audoin Pierre, Nguefang Solange, Mespoulhe Pauline, Caumes Eric, Alexandre Gaymard, Pistone Thierry, Laouenan Cedric, Delmas Christelle, Lepuil Severine, Ayala Sandrine, Lemouche Dalila, Dequand Stephane, Céline Dorival, Lina Bruno, Minerva Cervantes-Gonzalez, Duval Xavier, Costa Yolande, Leclercq Anne, Vabret Astrid, Theo Trioux, Samira Laribi, Roche-Gouanvic Elise, Houria Ichou, Deplanque Dominique, Isabelle Hoffmann, Marion Noret, Benmalek Nabil, Gaillanne Laurence, Mélanie Bertine, Lysa Tagherset, Peiffer-Smadja Nathan, Migaud Maria-Claire, Waucquier Nawal, Desille-Dugast Mireille, Nadia Ettalhaoui, Sarah Tubiana, Payet Christine, Romain Basmaci, Laine Fabrice, Attia Mikael, Patrick Rossignol, Charlene Da Silveira, Legrand Karine, Florentia Kaguelidou, Chirouze Catherine, Chan Thien Eric, Lebeaux David, Maude Bouscambert, Vesval Thiphaine, Charpentier Charlotte, Terzian Zaven, Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pasteur [Paris] (IP), Qiagen, BioMérieux, Gilead, Theratechnologie, Hologic, ViiV Healthcare, Abbvie, BMS, J&J, Pfizer, Beckton Dickinson, REACTing, 20-0424, Ministry of Health, ANRS, AAZ, Inserm, Sanofi Pasteur, Da Volterra, Biomerieux, Mylan, MSD, Medimune, Gilead Sciences, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Université Sorbonne Paris Nord, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), and Jonchère, Laurent
- Subjects
0301 basic medicine ,Microbiology (medical) ,Serum ,medicine.medical_specialty ,Saliva ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,[SDV]Life Sciences [q-bio] ,030106 microbiology ,Antigenemia ,Gastroenterology ,03 medical and health sciences ,Plasma ,0302 clinical medicine ,Antigen ,Internal medicine ,Medicine ,Sampling (medicine) ,030212 general & internal medicine ,Symptom onset ,Diagnostic ,business.industry ,SARS-CoV-2 ,COVID-19 ,General Medicine ,Serum samples ,3. Good health ,[SDV] Life Sciences [q-bio] ,Research Note ,Infectious Diseases ,Blood ,business ,Viral load - Abstract
Objectives Molecular assays on nasopharyngeal swabs remain the cornerstone of COVID-19 diagnostics. The high technicalities of nasopharyngeal sampling and molecular assays, as well as scarce resources of reagents, limit our testing capabilities. Several strategies failed, to date, to fully alleviate this testing process (e.g. saliva sampling or antigen testing on nasopharyngeal samples). We assessed the clinical performances of SARS-CoV-2 nucleocapsid antigen (N-antigen) ELISA detection in serum or plasma using the COVID-19 Quantigene® (AAZ, France) assay. Methods Performances were determined on 63 serum samples from 63 non-COVID patients and 227 serum samples (165 patients) from the French COVID and CoV-CONTACT cohorts with RT-PCR-confirmed SARS-CoV-2 infection, including 142 serum samples (114 patients) obtained within 14 days after symptom onset. Results Specificity was 98.4% (95% CI 95.3–100). Sensitivity was 79.3% overall (180/227, 95% CI, 74.0–84.6) and 93.0% (132/142, 95% CI, 88.7–97.2) within 14 days after symptom onset. Ninety-one of the included patients had serum samples and nasopharyngeal swabs collected in the same 24 hr. Among those with high nasopharyngeal viral loads, i.e. Ct value below 30 and 33, only 1/50 and 4/67 tested negative for N-antigenaemia, respectively. Among those with a negative nasopharyngeal RT-PCR, 8/12 presented positive N-antigenaemia; the lower respiratory tract was explored for six of these eight patients, showing positive RT-PCR in five cases. Discussion This is the first evaluation of a commercially available serum N-antigen detection assay. It presents a robust specificity and sensitivity within the first 14 days after symptoms onset. This approach provides a valuable new option for COVID-19 diagnosis, only requiring a blood draw and easily scalable in all clinical laboratories.
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- 2021
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