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18 results on '"LeBlanc, Emmanuelle V."'

3. Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus

Author

Whitesell, Luke, Robbins, Nicole, Huang, David S., McLellan, Catherine A., Shekhar-Guturja, Tanvi, LeBlanc, Emmanuelle V., Nation, Catherine S., Hui, Raymond, Hutchinson, Ashley, Collins, Cathy, Chatterjee, Sharanya, Trilles, Richard, Xie, Jinglin L., Krysan, Damian J., Lindquist, Susan, Porco, Jr., John A., Tatu, Utpal, Brown, Lauren E., Pizarro, Juan, and Cowen, Leah E.

Published
2019
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4. Regulatory dissection of the severe COVID-19 risk locus introgressed by Neanderthals

Author

Jagoda, Evelyn, primary, Marnetto, Davide, primary, Senevirathne, Gayani, additional, Gonzalez, Victoria, additional, Baid, Kaushal, additional, Montinaro, Francesco, additional, Richard, Daniel, additional, Falzarano, Darryl, additional, LeBlanc, Emmanuelle V, additional, Colpitts, Che C, additional, Banerjee, Arinjay, additional, Pagani, Luca, additional, and Capellini, Terence D, additional

Published
2023
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7. Overview Of The Canadian Clinician Investigator Trainees’ Research Presented At The 2020 CSCI-CITAC Joint Meeting

Author

Castanov, Valera, primary, Phuong, Melissa, additional, Bogie, Bryce J. M., additional, Jomaa, Danny, additional, LeBlanc, Emmanuelle V., additional, Macklin, Jillian, additional, Saint-Georges, Zacharie, additional, Suk, Yujin, additional, Wang, Wenxuan, additional, Ware, Matthaeus A., additional, Whittaker, Heather T., additional, and Pietrobon, Adam, additional

Published
2021
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10. Overview Of The Canadian Clinician Investigator Trainees’ Research Presented At The 2020 CSCI-CITAC Joint Meeting

Author

Castanov, Valera, Phuong, Melissa, Bogie, Bryce J. M., Jomaa, Danny, LeBlanc, Emmanuelle V., Macklin, Jillian, Saint-Georges, Zacharie, Suk, Yujin, Wang, Wenxuan, Ware, Matthaeus A., Whittaker, Heather T., Pietrobon, Adam, Castanov, Valera, Phuong, Melissa, Bogie, Bryce J. M., Jomaa, Danny, LeBlanc, Emmanuelle V., Macklin, Jillian, Saint-Georges, Zacharie, Suk, Yujin, Wang, Wenxuan, Ware, Matthaeus A., Whittaker, Heather T., and Pietrobon, Adam

Abstract

The 2020 Annual General Meeting (AGM) and Young Investigators’ Forum of the Canadian Society for Clinical Investigation / Société Canadienne de Recherches Clinique (CSCI/SCRC) and Clinician Investigator Trainee Association of Canada/Association des Cliniciens-Chercheurs en Formation du Canada (CITAC/ACCFC) was the first meeting to be hosted virtually. The theme was “Navigating Uncertainty, Embracing Change and Empowering the Next Generation of Clinician-Scientists”, and the meeting featured lectures and workshops that were designed to provide knowledge and skills for professional development of clinician investigator trainees. The opening remarks were given by Jason Berman (President of CSCI/SCRC), Tina Marvasti (President of CITAC/ACCFC) and Nicola Jones (University of Toronto Clinician Investigator Program Symposium Chair). Dr. Michael Strong, President of the Canadian Institutes of Health Research, delivered the keynote presentation titled “CIHR’s COVID-19 Response and Strategic Planning”. Dr. John Bell (University of Ottawa) received the CSCI Distinguished Scientist Award, Dr. Stanley Nattel (Université de Montréal) received the CSCI-RCPSC Henry Friesen Award (RCPSC; Royal College of Physicians and Surgeons of Canada) and Dr. Meghan Azad (University of Manitoba) received the CSCI Joe Doupe Young Investigator Award. Each scientist delivered talks on their award-winning research. The interactive workshops were “Developing Strategies to Maintain Wellness”, “Understanding the Hidden Curriculum: Power and Privilege in Science and Medicine”, “Hiring a Clinician Scientist Trainee: What Leaders Are Looking For” and “COVID-19: A Case Study for Pivoting Your Research”. The AGM included presentations from clinician investigator trainees nationwide. Over 70 abstracts were showcased, most are summarized in this review, and six were selected for oral presentations.

Published
2021

13. Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors: Optimization of Whole-Cell Anticryptococcal Activity and Insights into the Structural Origins of Cryptococcal Selectivity

Author

Marcyk, Paul T., primary, LeBlanc, Emmanuelle V., additional, Kuntz, Douglas A., additional, Xue, Alice, additional, Ortiz, Francisco, additional, Trilles, Richard, additional, Bengtson, Stephen, additional, Kenney, Tristan M. G., additional, Huang, David S., additional, Robbins, Nicole, additional, Williams, Noelle S., additional, Krysan, Damian J., additional, Privé, Gilbert G., additional, Whitesell, Luke, additional, Cowen, Leah E., additional, and Brown, Lauren E., additional

Published
2021
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17. Design and Synthesis of Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors

Author

Huang, David S., LeBlanc, Emmanuelle V., Shekhar-Guturja, Tanvi, Robbins, Nicole, Krysan, Damian J., Pizarro, Juan, Whitesell, Luke, Cowen, Leah E., and Brown, Lauren E.

Abstract

The molecular chaperone Hsp90, essential in all eukaryotes, plays a multifaceted role in promoting survival, virulence, and drug resistance across diverse pathogenic fungal species. The chaperone is also critically important, however, to the pathogen’s human host, preventing the use of known clinical Hsp90 inhibitors in antifungal applications due to concomitant host toxicity issues. With the goal of developing Hsp90 inhibitors with acceptable therapeutic indices for the treatment of invasive fungal infections, we initiated a program to design and synthesize potent inhibitors with selective activity against fungal Hsp90 isoforms over their human counterparts. Building on our previously reported derivatization of resorcylate natural products to produce fungal-selective compounds, we have developed a series of synthetic aminopyrazole-substituted resorcylate amides with broad, potent, and fungal-selective Hsp90 inhibitory activity. Herein we describe the synthesis of this series, as well as biochemical structure–activity relationships driving selectivity for the Hsp90 isoforms expressed by Cryptococcus neoformansand Candida albicans, two pathogenic fungi of major clinical importance.

Published
2020
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18. Overview of The Canadian Clinician Investigator Trainees' Research Presented at CSCI-CITAC Joint Meeting.

Author

Castanov, Valera, Phuong, Melissa S., Turco, Claudia, Eskinazi, Sani, Lao, Robert X., LeBlanc, Emmanuelle V., Pietrobon, Adam, Saint-Georges, Zacharie, Wang, Wenxuan, Yuan, Amelia T., Whittaker, Heather T., Phuong, Melissa, Lao, Robert, LeBlanc, Emmanuelle, Yuan, Amelia, and Whittaker, Heather

Abstract

The 2021 Annual Joint Meeting (AJM) and Young Investigators' Forum of the Canadian Society for Clinical Investigation / Société Canadienne de Recherches Clinique (CSCI/SCRC) and Clinician Investigator Trainee Association of Canada/Association des Cliniciens-Chercheurs en Formation du Canada (CITAC/ACCFC) was hosted virtually on November 14-16th, 2021. The theme of the AJM was "Communication, Collaboration, and Tools for the Next Generation of Clinician Scientists", and emphasized lectures, panels and interactive workshops designed to provide knowledge and skills for professional development of clinician investigator trainees. The opening remarks were given by Nicola Jones (President of CSCI/SCRC) and Adam Pietrobon (Past President of CITAC/ACCFC). The keynote speaker was Dr. Timothy Caulfield, who delivered the presentation titled "Communication in the Era of Misinformation". Dr. Michael Hill (University of Calgary) received the CSCI Distinguished Scientist Award and Dr. Philippe Campeau (Université de Montréal) received the CSCI Joe Doupe Young Investigator Award. Each of the scientists delivered award winning talks during the symposium titled "All the King's Horses and All the King's Men" and "Understanding Growth Plate Disorders to Better Treat Them", respectively. The three interactive workshops included "Data Visualization", "Science Communication on Social Media" and "Mentorship in Action". The two panels were "CIHR Engagement: Challenges and Opportunities in the Clinician Investigator Career Path" and "Early Career Investigator Panel". The AJM also included presentations from clinician investigator trainees from across the country. Over 60 abstracts were showcased at this year's meeting, most of which are summarized in this review. Six outstanding abstracts were selected for oral presentations during the President's Forum. [ABSTRACT FROM AUTHOR]

Published
2022
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