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This paper explores the role of women empowerment and labour on enabling farmers to cross two hurdles: adopt and intensify soil fertility management (SFM), coming after six decades of SFM research that disseminated several technologies. Despite the assertion that productivity gains cannot be realized unless drivers of soil degradation are addressed, SFM usage is low. We collected data from a systematically drawn random sample of 238 farmers, representing 30% of farming households in five villages in Malawi's Rift Valley escarpments and analysed using a double‐hurdle model. Descriptive results show that 90% of the respondents used inorganic fertilizers, 72% planted legumes and 57% applied organic manure. The empirical analysis shows that one percentage point increase in dependency ratio reduces probability to apply organic amendments by 0.4 percentage points and erodes the positive influence of increasing labour on application of inorganic fertilizer. As women become increasingly empowered in decision‐making, there are significant trade‐offs: a percentage point increase in women empowerment in agriculture index (WEAI) potentially leads to a one‐third percentage point increase in the area allocated to legumes but reduces the amount of organic manure applied with higher elasticity of two percentage points. Considering the trade‐offs, sustainable intensification could be achieved by harnessing the positive influences while concurrently reducing the negative ones over a decision space. Notably, addressing the negative effect associated with women empowerment on manuring could unlock potentials for integrated SFM as women are already engaged in legume cropping. [ABSTRACT FROM AUTHOR]

A new approach for the synthesis of podophyllotoxin-naphthoquinone compounds using microwave-assisted three-component reactions is reported in this study. Novel podophyllotoxin-naphthoquinone derivatives with modification on ring E were synthesized. All the synthetic compounds were assessed in terms of their cytotoxicity profile against four cancer cell lines (KB, HepG2, A549, and MCF7), and noncancerous Hek-293 cell lines. Notably, treatment of SK-LU-1 cells with compounds 5a and 5b resulted in G2/M phase arrest of the cell cycle, caspase-3/7 activation, and apoptosis. Additionally, molecular docking studies were performed and showed important interaction of two compounds against residues in the colchicine-binding-site of tubulin as well. Taken together, compounds 5a and 5b were identified as potent anticancer agents., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)

The efficacy of calcium phosphate (CaP) ceramics in healing large bone defects is, in general, not as high as that of autologous bone grafting. Recently, we reported that CaP ceramics with osteoinductive properties were as efficient in healing an ilium defect of a sheep as autologous bone graft was, which makes this subclass of CaP ceramics a powerful alternative for bone regeneration. Although osteoinduction by CaP ceramics has been shown in several large animal models it is sporadically reported in mice. Because the lack of a robust mouse model has delayed understanding of the mechanism, we screened mice from 11 different inbred mouse strains for their responsiveness to subcutaneous implantation of osteoinductive tricalcium phosphate (TCP). In only two strains (FVB and 129S2) the ceramic induced bone formation, and in particularly, in FVB mice, bone was found in all the tested mice. We also demonstrated that other CaP ceramics induced bone formation at the same magnitude as that observed in other animal models. Furthermore, VEGF did not significantly increase TCP induced bone formation. The mouse model here described can accelerate research of osteoinductive mechanisms triggered by CaP ceramics and potentially the development of therapies for bone regeneration., (Copyright © 2012 Elsevier Ltd. All rights reserved.)

Objective: To show the botulinum toxin interest and limits in the elderly presenting a limbs spastic hypertonia and/or a dystonia, through a clinical study and a literature review., Method: We report a 6 years and 8 months retrospective single center study, concerning 49 patients, all of them was more than 70 years old and had received one or several botulinum toxin injections for a limbs spastic hypertonia and/or a dystonia., Results: The population average was 76,9 years old (70 to 92 years old). It was possible to realize several sessions for the same patient if respecting a three months interval between two sessions. No major side effects was noticed. More than half of the patients felt a significant improvement of their life quality, their functional status and/or on pain. A multidisciplinary care was systematically associated with the botulinum toxin., Conclusion: The botulinum toxin is an additional asset for the spasticity care of the geriatric patient in rehabilitation, if indications and contraindications are advisedly targeted. The age cannot be considered as a limitating factor.

Introduction: This paper is a review of the literature on assessment tools in lower limb amputees., Material and Methods: The authors have research on Medline(R) data base the different tools with keys words "lower limb amputee or amputation, functional evaluation or outcome assessment tools, activity of daily living", and have completed the research with the references of papers., Results: A comprehensive approach of the consequences of an amputation and of the outcome of prosthetic care should include an evaluation of gait, use of the prosthesis in activities of daily life, acceptability and satisfaction with the device., Discussion: Functional assessment tools that are validated are recent, and most of them were developed in English. They take into account the use and the acceptance of the device, but there is no study using them for an important sample population., Conclusion: It is now necessary to translate the recent tools into French, and to confirm their validity and sensitivity to change.