Search

Your search keyword '"Le Jan, Sebastien"' showing total 15 results
Start Over Author "Le Jan, Sebastien"
15 results on '"Le Jan, Sebastien"'

2. Elastin-derived peptides favor type 2 innate lymphoid cells in COPD

Author

Lahire, Sarah, primary, Fichel, Caroline, additional, Rubaszewski, Oceane, additional, Lereverend, Cedric, additional, Audonnet, Sandra, additional, Visneux, Vincent, additional, Perotin, Jeanne-Marie, additional, Deslee, Gaetan, additional, Le Jan, Sebastien, additional, Potteaux, Stephane, additional, Le Naour, Richard, additional, and Pommier, Arnaud, additional more...

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results

7. Neutrophil Extracellular Traps Generation Relates with Early Stage and Vascular Complications in Systemic Sclerosis

Author

Didier, Kevin, Giusti, Delphine, Le Jan, Sebastien, Terryn, Christine, Muller, Celine, Pham, Bach Nga, Le Naour, Richard, Antonicelli, Frank, Servettaz, Amelie, Immuno-Régulation dans les Maladies Auto-Immunes Inflammatoires et le Cancer - EA 7509 (IRMAIC), Université de Reims Champagne-Ardenne (URCA), Plateforme en Imagerie Cellulaire et Tissulaire (PICT), Université de Reims Champagne-Ardenne (URCA)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), and Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV) more...

Subjects
NET, integumentary system, systemic sclerosis, lcsh:R, neutrophil extracellular traps, [SDV.IMM]Life Sciences [q-bio]/Immunology, NETosis, lcsh:Medicine, scleroderma, skin and connective tissue diseases, PMN, Article, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Systemic sclerosis (SSc) is a systemic disease characterized by a great clinical and immunological heterogeneity whose pathophysiology is still being unraveled. Recently, innate immunity has been proposed to participate to the pathogenesis of SSc. In this study, we investigated the release of neutrophil extracellular traps (NETs) according to patient phenotype. Polymorphonuclear neutrophils (PMN) from 34 SSc patients and 26 healthy controls were stimulated by serum from SSc or healthy subject. NETs were visualized using epifluorescence microscope after DNA, myeloperoxidase, and Histone H3 tagging. Area of NETs were quantified using an original macro running in ImageJ&reg, software. PMN from SSc patients were significantly more prone to releasing NETs than control PMN after autologous stimulation. PMN from patients with severe vascular complications (pulmonary arterial hypertension, digital ulcers) produced more NETs than PMN from other SSc patients and their aberrant NET production appeared to be sustained over time. In patients with pulmonary interstitial disease or extensive cutaneous fibrosis, NET production was high at an early stage of the disease before progressively decreasing. Both serum factors and PMN activation status were involved in the enhanced production of NETs in SSc. Consequently, neutrophils and especially NETosis represent new physiopathological and therapeutic fields in SSc. more...

Published
2020
Full Text
View/download PDF

12. NRP1 Presented in trans to the Endothelium Arrests VEGFR2 Endocytosis, Preventing Angiogenic Signaling and Tumor Initiation

Author

Koch, Sina, van Meeteren, Laurens A., Morin, Eric, Testini, Chiara, Weström, Simone, Björkelund, Hanna, Le Jan, Sebastien, Adler, Jeremy, Berger, Philipp, Claesson-Welsh, Lena, Koch, Sina, van Meeteren, Laurens A., Morin, Eric, Testini, Chiara, Weström, Simone, Björkelund, Hanna, Le Jan, Sebastien, Adler, Jeremy, Berger, Philipp, and Claesson-Welsh, Lena more...

Abstract

Neuropilin 1 (NRP1) modulates angiogenesis by binding vascular endothelial growth factor (VEGF) and its receptor, VEGFR2. We examined the consequences when VEGFR2 and NRP1 were expressed on the same cell (cis) or on different cells (trans). In cis, VEGF induced rapid VEGFR2/NRP1 complex formation and internalization. In trans, complex formation was delayed and phosphorylation of phospholipase C gamma (PLC gamma) and extracellular regulated kinase 2 (ERK2) was prolonged, whereas ERK1 phosphorylation was reduced. Trans complex formation suppressed initiation and vascularization of NRP1-expressing mouse fibrosarcoma and melanoma. Suppression in trans required high-affinity, steady-state binding of VEGF to NRP1, which was dependent on the NRP1 C-terminal domain. Compatible with a trans effect of NRP1, quiescent vasculature in the developing retina showed continuous high NRP1 expression, whereas angiogenic sprouting occurred where NRP1 levels fluctuated between adjacent endothelial cells. Therefore, through communication in trans, NRP1 can modulate VEGFR2 signaling and suppress angiogenesis. more...

Published
2014
Full Text
View/download PDF

14. List of Contributors

Author

Ambalam, Padma, Antonicelli, Frank, Asrafuzzaman, Syed, Bagchi, Debasis, Bernard, Philippe, Bhakkiyalakshmi, Elango, Biswas, Chhanda, Bonesi, Marco, Bosco, Nabil, Cexus, Olivier, Chaffee, Scott, Chatterjee, Shampa, Cheong, Dorothy H.J., Choe, Sung J., Das, Amitava, De Meester, Ingrid, Del Rosario, Fernando, Dholia, Neeraj, Doble, Mukesh, Falasca, Katia, Ganguly, Koustav, George, Leema, Ghosh, Nandini, Grimes, Catherine L., He, Zhaoping, Hood, Elizabeth D., Howes, Melanie-Jayne R., Hussain, Shaik Abdul, Jeong, Se K., Jungraithmayr, Wolfgang, Kabuki, Toshihide, Kawasaki, Yoshihiro, Kothari, Charmy, Larbi, Anis, Le Jan, Sébastien, Lee, Eun-Ji, Lee, Jeong-Sang, Lee, Robert J., Lim, Chae J., Loizzo, Monica R., Menichini, Francesco, Mallilankaraman, Karthik B., Manoj Kumar Kingsley, Selvaraj, McMahon, Derek B., Melnyk, James E., Moriya, Tomohiro, Moyes, David L., Na, Hye-Kyung, Nair, Pradeep M.K., Nishihira, Jun, Nishimura, Mie, Park, Keedon, Park, Kyungho, Patel, Priyal, Peethambaran, Bela, Pithva, Sheetal, Plée, Julie, Pothuraju, Ramesh, Prasad, Nupoor, Purama, Ravi Kiran, Qiao, Yongkang, Raman, Maya, Ramkumar, Kunka M., Ramteke, Prerna, Reale, Marcella, Roy, Sashwati, Sakai, Fumihiko, Salwa, Hyndavi, Sampath, Venkatesh, Schaefer, Amy K., Sen, Chandan K., Shah, Rahul, Sharma, Ashish K., Sharma, Minaxi, Sifers, Travis M., Simes, Dina C., Sireesh, Dornadula, Surh, Young-Joon, Thimraj, Tania A., Tran, Thai, Tundis, Rosa, Upadhyay, Swapna, Vazquez-Medina, Jose P., Viegas, Carla S.B., Vishnu Bhat, Ballambattu, Vliegen, Gwendolyn, Witherden, Elizabeth A., Yadav, Umesh C.S., Yenuganti, Vengala Rao, and You, Huihui more...

Published
2018
Full Text
View/download PDF