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1. Comment on Shah et al. Genetic Characteristics and Phylogeographic Dynamics of Lagoviruses, 1988–2021. Viruses 2023, 15, 815

Author

Abrantes, Joana, primary, Bertagnoli, Stéphane, additional, Cavadini, Patrizia, additional, Esteves, Pedro J., additional, Gavier-Widén, Dolores, additional, Hall, Robyn N., additional, Lavazza, Antonio, additional, Le Gall-Reculé, Ghislaine, additional, Mahar, Jackie E., additional, Marchandeau, Stéphane, additional, and Lopes, Ana M., additional

Published
2024
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6. Development and Evaluation of a Duplex Lateral Flow Assay for the Detection and Differentiation between Rabbit Haemorrhagic Disease Virus Lagovirus europaeus/GI.1 and /GI.2

Author

Fresco-Taboada, Alba, Montón, Mercedes, Tapia, Istar, Soria, Elena, Bárcena, Juan, Guillou-Cloarec, Cécile, Le Gall-Reculé, Ghislaine, Blanco, Esther, Rueda, Paloma, Fresco-Taboada, Alba, Montón, Mercedes, Tapia, Istar, Soria, Elena, Bárcena, Juan, Guillou-Cloarec, Cécile, Le Gall-Reculé, Ghislaine, Blanco, Esther, and Rueda, Paloma

Abstract

Rabbit Haemorrhagic Disease is caused by a virus that affects the liver, the spleen and the lungs of rabbits, causing hepatitis, splenomegaly and haemorrhages. A new genotype of the virus was first reported in France in 2010 and has spread globally since then, replacing most of the circulating former viruses in many countries. The detection of the virus and the differentiation of both genotypes is of crucial importance for disease surveillance. In this article, a rapid test for antigen detection is described and evaluated, providing the first description of a quick and easy-to-use test that allows for the simultaneous detection and differentiation of the genotypes. A total of 136 samples, rabbit liver samples and liver exudates (liquid collected after freeze–thawing) classified as infected and non-infected, were analysed, with good results. These data confirm that the developed rapid test can be used as a reliable diagnostic test for disease surveillance, especially in farms and the fiel, Rabbit Haemorrhagic Disease Virus 2 (RHDV2, recently named Lagovirus europaeus/GI.2) was first reported in France in 2010 and has spread globally since then, replacing most of the circulating former RHDV (genotype GI.1) in many countries. The detection and differentiation of both genotypes is of crucial importance for the surveillance of the disease. In this article, a duplex lateral flow assay (LFA) for antigen detection is described and evaluated, providing the first description of a quick and easy-to-use test that allows for the simultaneous detection and differentiation of RHDV genotypes GI.1 and GI.2. A panel of GI.1- or GI.2-infected and non-infected rabbit liver samples and liver exudates (136 samples) was analysed, obtaining a total sensitivity of 94.4% and specificity of 100%. These data confirm that the developed duplex LFA can be used as a reliable diagnostic test for RHD surveillance, especially in farms and the fiel

Published
2022

7. Genetic data from avian influenza and avian paramyxoviruses generated by the European network of excellence (EPIZONE) between 2006 and 2011—Review and recommendations for surveillance

Author

Dundon, William G., Heidari, Alireza, Fusaro, Alice, Monne, Isabella, Beato, Maria Serena, Cattoli, Giovanni, Koch, Guus, Starick, Elke, Brown, Ian H., Aldous, Elisabeth W., Briand, François-Xavier, Le Gall-Reculé, Ghislaine, Jestin, Véronique, Jørgensen, Poul H., Berg, Mikael, Zohari, Siamak, Metreveli, Giorgi, Munir, Muhammad, Ståhl, Karl, Albina, Emmanuel, Hammoumi, Saliha, Gil, Patricia, Servan de Almeida, Renata, Śmietanka, Krzysztof, Domańska-Blicharz, Katarzyna, Minta, Zenon, Van Borm, Steven, van den Berg, Thierry, Moreno Martin, Ana, Barbieri, Ilaria, and Capua, Ilaria

Published
2012
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8. Development and Evaluation of a Duplex Lateral Flow Assay for the Detection and Differentiation between Rabbit Haemorrhagic Disease Virus Lagovirus europaeus/GI.1 and /GI.2

Author

Fresco-Taboada, Alba, primary, Montón, Mercedes, additional, Tapia, Istar, additional, Soria, Elena, additional, Bárcena, Juan, additional, Guillou-Cloarec, Cécile, additional, Le Gall-Reculé, Ghislaine, additional, Blanco, Esther, additional, and Rueda, Paloma, additional

Published
2022
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11. Retrospective studies on rabbit haemorrhagic disease outbreaks caused by RHDV GI.2 virus on farms in France from 2013 to 2018

Author

Huneau-Salaün, Adeline, primary, Boucher, Samuel, additional, Fontaine, Julie, additional, Le Normand, Bernadette, additional, Lopez, Sébastien, additional, Maurice, Thimothée, additional, Nouvel, Laurence, additional, Bruchec, Arthur, additional, Coton, Jenna, additional, Martin, Guillaume, additional, Le Gall-Reculé, Ghislaine, additional, and Le Bouquin, Sophie, additional

Published
2021
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13. Retrospective studies on rabbit haemorrhagic disease outbreaks caused by RHDV GI.2 virus on farms in France from 2013 to 2018

Author

Ministère de l'Agriculture et de l'Alimentation, Francia, Huneau-Salaün, Adeline, Boucher, Samuel, Fontaine, Julie, Le Normand, Bernadette, Lopez, Sébastien, Maurice, Thimothée, Nouvel, Laurence, Bruchec, Arthur, Coton, Jenna, Martin, Guillaume, Le Gall-Reculé, Ghislaine, Le Bouquin, Sophie, Ministère de l'Agriculture et de l'Alimentation, Francia, Huneau-Salaün, Adeline, Boucher, Samuel, Fontaine, Julie, Le Normand, Bernadette, Lopez, Sébastien, Maurice, Thimothée, Nouvel, Laurence, Bruchec, Arthur, Coton, Jenna, Martin, Guillaume, Le Gall-Reculé, Ghislaine, and Le Bouquin, Sophie

Abstract

[EN] Rabbit haemorrhagic disease (RHD) is a critical health threat to the rabbit industry in Europe. In 2018, the French rabbit industry adopted a voluntary control plan against this disease. In this context, two epidemiological studies were conducted on RHD outbreaks that occurred between 2013 and 2018 in France. The objectives were to describe the spread of RHD due to the new genotype RHDV GI.2 (rabbit haemorrhagic disease virus GI.2) and to identify rearing factors influencing the occurrence of the disease in order to guide the prevention measures recommended in the control plan. An analysis of cases on 295 farms between 2013 and 2017 showed that 32% of farms were affected at least once; the incidence of the disease increased in 2016-2017 compared to 2013-2015. Farms already affected in 2013-2015 had a higher risk of being infected in 2016-2017 than those that remained unaffected until 2015 (Relative Risk and 95% Confident Interval 1.7 [1.1-2.7]). A case-control study carried out between 2016 and 2018 on 37 outbreaks and 32 control farms revealed variability in biosecurity and decontamination practices between farms. The risk of being infected tends to be linked to these practices, but certain structural factors (e.g. the manure disposal system, transfer of rabbits at weaning) could also influence the risk of virus introduction into farms. In the context of a limited vaccination coverage of the farms (only females are vaccinated), these hypotheses will be studied further, using information from the RHD outbreak monitoring system implemented at the same time as the control plan in 2018.

Published
2021

14. Development and Evaluation of a Duplex Lateral Flow Assay for the Detection and Differentiation between Rabbit Haemorrhagic Disease Virus Lagovirus europaeus /GI.1 and /GI.2.

Author

Fresco-Taboada, Alba, Montón, Mercedes, Tapia, Istar, Soria, Elena, Bárcena, Juan, Guillou-Cloarec, Cécile, Le Gall-Reculé, Ghislaine, Blanco, Esther, and Rueda, Paloma

Subjects
RABBIT diseases, VIRUS diseases, RABBITS, HEPATITIS E virus
Abstract

Simple Summary: Rabbit Haemorrhagic Disease is caused by a virus that affects the liver, the spleen and the lungs of rabbits, causing hepatitis, splenomegaly and haemorrhages. A new genotype of the virus was first reported in France in 2010 and has spread globally since then, replacing most of the circulating former viruses in many countries. The detection of the virus and the differentiation of both genotypes is of crucial importance for disease surveillance. In this article, a rapid test for antigen detection is described and evaluated, providing the first description of a quick and easy-to-use test that allows for the simultaneous detection and differentiation of the genotypes. A total of 136 samples, rabbit liver samples and liver exudates (liquid collected after freeze–thawing) classified as infected and non-infected, were analysed, with good results. These data confirm that the developed rapid test can be used as a reliable diagnostic test for disease surveillance, especially in farms and the field. Rabbit Haemorrhagic Disease Virus 2 (RHDV2, recently named Lagovirus europaeus/GI.2) was first reported in France in 2010 and has spread globally since then, replacing most of the circulating former RHDV (genotype GI.1) in many countries. The detection and differentiation of both genotypes is of crucial importance for the surveillance of the disease. In this article, a duplex lateral flow assay (LFA) for antigen detection is described and evaluated, providing the first description of a quick and easy-to-use test that allows for the simultaneous detection and differentiation of RHDV genotypes GI.1 and GI.2. A panel of GI.1- or GI.2-infected and non-infected rabbit liver samples and liver exudates (136 samples) was analysed, obtaining a total sensitivity of 94.4% and specificity of 100%. These data confirm that the developed duplex LFA can be used as a reliable diagnostic test for RHD surveillance, especially in farms and the field. [ABSTRACT FROM AUTHOR]

Published
2022
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15. Retrospective Analysis Shows That Most RHDV GI.1 Strains Circulating Since the Late 1990s in France and Sweden Were Recombinant GI.3P–GI.1d Strains

Author

Abrantes, Joana, primary, Lopes, Ana M., additional, Lemaitre, Evelyne, additional, Ahola, Harri, additional, Banihashem, Fereshteh, additional, Droillard, Clément, additional, Marchandeau, Stéphane, additional, Esteves, Pedro J., additional, Neimanis, Aleksija, additional, and Le Gall-Reculé, Ghislaine, additional

Published
2020
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16. Genetic diversity and evolution of Hare Calicivirus (HaCV), a recently identified lagovirus from Lepus europaeus

Author

Droillard, Clément, primary, Lemaitre, Evelyne, additional, Chatel, Marina, additional, Quéméner, Agnès, additional, Briand, François-Xavier, additional, Guitton, Jean-Sébastien, additional, Marchandeau, Stéphane, additional, Le Pendu, Jacques, additional, Eterradossi, Nicolas, additional, and Le Gall-Reculé, Ghislaine, additional

Published
2020
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18. Relationships between host-species specificities and glycan specificities of 1 pathogenic and non-pathogenic lagoviruses

Author

Lopes, Ana, Breiman, Adrien, Lora, Mónica, Le Moullac-Vaidye, Béatrice, Galanina, Oxana, Nyström, Kristina, Marchandeau, Stéphane, Le Gall-Reculé, Ghislaine, Strive, Tanja, Neimanis, Aleksija, Bovin, Nicolai, Ruvoën-Clouet, Nathalie, Esteves, Pedro, Abrantes, Joana, Le Pendu, Jacques, Bernardo, Elizabeth, Host-Pathogen Interactions in the Regulation of Immune Responses (CRCINA-ÉQUIPE 5), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), CIBIO InBIO, Ctr Invest Biodiversidade & Recursos Genet [Vairão, Portugal], Universidade do Porto = University of Porto, Unit for Multidisciplinary Research in Biomedicine - UMIB [Porto, Portugal] (Department of Anatomy), Universidade do Porto = University of Porto-Institute of Biomedical Sciences Abel Salazar - ICBAS [Porto, Portugal], Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry (IBCh RAS), Russian Academy of Sciences [Moscow] (RAS), Department of Infectious Diseases [Gothenburg, Sweden], Gothenburg University [Sweden], Département recherche et expertise [Nantes], Office national de la chasse et de la faune sauvage - ONCFS [Paris], Laboratoire Ploufragan Plouzane, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Université Bretagne Loire (UBL), Health & Biosecurity [Canberra, ACT, Australia] (CSIRO), Black Mountain Laboratories [Canberra, ACT, Australia], Department of Pathology and Wildlife Diseases [Uppsala, Sweden], National Veterinary Institute [Uppsala] (SVA), Department of Biomedical Sciences and Veterinary Public Health [Uppsala, Sweden], Swedish University of Agricultural Sciences (SLU), Departamento de Biologia [Porto, Portugal], Universidade do Porto = University of Porto-Faculdade de Ciências da Universidade do Porto (FCUP), Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde - CESPU [Gandra, Portugal], Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Universidade do Porto, Universidade do Porto-Institute of Biomedical Sciences Abel Salazar - ICBAS [Porto, Portugal], Faculdade de Ciências da Universidade do Porto (FCUP), and Universidade do Porto-Universidade do Porto

Subjects
France h, CSIRO 19 Health&Biosecurity, Ploufragan, Environmental and Occupational Health & Safety (Anses), 14 Diseases, France f, France g, National Hunting and Wildlife 15 Agency (ONCFS), [SDV.CAN]Life Sciences [q-bio]/Cancer, Nantes, Rennes, ACT, Australia i, 17 Ploufragan-Plouzané Laboratory, Canberra, Black Mountain Laboratories, [SDV.CAN] Life Sciences [q-bio]/Cancer, French 16 Agency for Food, Sweden e, University Bretagne Loire, Gothenburg, Avian and Rabbit Virology Immunology Parasitology 18 Unit, Research and expertise Department, Gothenburg University
Abstract

International audience; The rabbit hemorrhagic disease virus (RHDV) and the European brown hare syndrome virus (EBHSV) are two lagoviruses from the family Caliciviridae that cause fatal diseases in two leporid genera, Oryctolagus and Lepus, respectively. In the last few years, several examples of host jumps of lagoviruses among leporids were recorded. In addition, a new pathogenic genotype of RHDV emerged and many non-pathogenic strains of lagoviruses have been described. The molecular mechanisms behind host shifts and the emergence of virulence are unknown. Since RHDV uses glycans of the histo-blood group antigen type as attachment factors to initiate infection, we studied if glycan specificities of the new pathogenic RHDV genotype, non-pathogenic lagoviruses and EBHSV potentially play a role in determining host range and virulence of lagoviruses. We observed binding to A, B or H antigens of the histo-blood group family for all strains known to primarily infect European rabbits (Oryctolagus cuniculus), that have recently been classified as GI strains. Yet, it failed to explain the emergence of virulence since similar glycan specificities were found between several pathogenic and non-pathogenic strains. EBHSV, recently classified as GII.1, instead, bound to terminal -linked N-acetylglucosamine residues of O-glycans. Expression of these attachment factors in the upper respiratory and digestive tracts in three lagomorph species (Oryctolagus cuniculus, Lepus europaeus and Sylvilagus floridanus) showed species- specific patterns in relation with the susceptibility to these viruses, indicating that species-specific glycan expression is likely a major contributor of lagoviruses host specificity and range.

Published
2017

19. Host-Specific Glycans Are Correlated with Susceptibility to Infection by Lagoviruses, but Not with Their Virulence

Author

Lopes, Ana M., primary, Breiman, Adrien, additional, Lora, Mónica, additional, Le Moullac-Vaidye, Béatrice, additional, Galanina, Oxana, additional, Nyström, Kristina, additional, Marchandeau, Stephane, additional, Le Gall-Reculé, Ghislaine, additional, Strive, Tanja, additional, Neimanis, Aleksija, additional, Bovin, Nicolai V., additional, Ruvoën-Clouet, Nathalie, additional, Esteves, Pedro J., additional, Abrantes, Joana, additional, and Le Pendu, Jacques, additional

Published
2018
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20. Proposal for a unified classification system and nomenclature of lagoviruses

Author

Agence Nationale de la Recherche (France), Région des Pays de la Loire, European Commission, Ministero della Salute, Swedish Research Council, Fundação para a Ciência e a Tecnologia (Portugal), Le Pendu, Jacques, Abrantes, Joana, Bertagnoli, Stéphane, Guitton, Jean-Sébastien, Le Gall-Reculé, Ghislaine, Lopes, Ana Margarida, Marchandeau, Stéphane, Alda, Fernando, Almeida, Tereza, Célio, Alves Paulo, Bárcena, Juan, Burmakina, Galina, Blanco, Esther, Calvete, Carlos, Cavadini, Patrizia, Cooke, Brian, Dalton, Kevin, Delibes Mateos, Miguel, Deptula, Wieslaw., Eden, John Sebastian, Wang, Fang, Ferreira, Catarina C., Ferreira, Paula, Foronda, Pilar, Gonçalves, David, Gavier-Widén, Dolores, Hall, Robin, Hukowska-Szematowicz, Beata, Kerr, Peter, Kovaliski, John, Lavazza, Antonio, Mahar, Jackie, Malogolovkin, Alexander, Marques, Raquel M., Marques, Sara, Martín-Alonso, Aaron, Monterroso, Pedro, Moreno, Sacramento, Mutze, Greg, Neimanis, Aleksija, Niedzwiedzka-Rystwej, Paulina, Peacock, David, Parra, Francisco, Rocchi, Mara, Rouco, Carlos, Ruvoën-Clouet, Nathalie, Silva, Eliane, Silvério, Diogo, Strive, Tanja, Thompson, Gertrudes, Tokarz-Deptula, Beata, Esteves, Pedro, Agence Nationale de la Recherche (France), Région des Pays de la Loire, European Commission, Ministero della Salute, Swedish Research Council, Fundação para a Ciência e a Tecnologia (Portugal), Le Pendu, Jacques, Abrantes, Joana, Bertagnoli, Stéphane, Guitton, Jean-Sébastien, Le Gall-Reculé, Ghislaine, Lopes, Ana Margarida, Marchandeau, Stéphane, Alda, Fernando, Almeida, Tereza, Célio, Alves Paulo, Bárcena, Juan, Burmakina, Galina, Blanco, Esther, Calvete, Carlos, Cavadini, Patrizia, Cooke, Brian, Dalton, Kevin, Delibes Mateos, Miguel, Deptula, Wieslaw., Eden, John Sebastian, Wang, Fang, Ferreira, Catarina C., Ferreira, Paula, Foronda, Pilar, Gonçalves, David, Gavier-Widén, Dolores, Hall, Robin, Hukowska-Szematowicz, Beata, Kerr, Peter, Kovaliski, John, Lavazza, Antonio, Mahar, Jackie, Malogolovkin, Alexander, Marques, Raquel M., Marques, Sara, Martín-Alonso, Aaron, Monterroso, Pedro, Moreno, Sacramento, Mutze, Greg, Neimanis, Aleksija, Niedzwiedzka-Rystwej, Paulina, Peacock, David, Parra, Francisco, Rocchi, Mara, Rouco, Carlos, Ruvoën-Clouet, Nathalie, Silva, Eliane, Silvério, Diogo, Strive, Tanja, Thompson, Gertrudes, Tokarz-Deptula, Beata, and Esteves, Pedro

Abstract

Lagoviruses belong to the Caliciviridae family. They were first recognized as highly pathogenic viruses of the European rabbit (Oryctolagus cuniculus) and European brown hare (Lepus europaeus) that emerged in the 1970–1980s, namely, rabbit haemorrhagic disease virus (RHDV) and European brown hare syndrome virus (EBHSV), according to the host species from which they had been first detected. However, the diversity of lagoviruses has recently expanded to include new related viruses with varying pathogenicity, geographic distribution and host ranges. Together with the frequent recombination observed amongst circulating viruses, there is a clear need to establish precise guidelines for classifying and naming lagovirus strains. Therefore, here we propose a new nomenclature based on phylogenetic relationships. In this new nomenclature, a single species of lagovirus would be recognized and called Lagovirus europaeus. The species would be divided into two genogroups that correspond to RHDV- and EBHSV-related viruses, respectively. Genogroups could be subdivided into genotypes, which could themselves be subdivided into phylogenetically well-supported variants. Based on available sequences, pairwise distance cutoffs have been defined, but with the accumulation of new sequences these cutoffs may need to be revised. We propose that an international working group could coordinate the nomenclature of lagoviruses and any proposals for revision.

Published
2017

22. Proposal for a unified classification system and nomenclature of lagoviruses

Author

Le Pendu, Jacques, primary, Abrantes, Joana, additional, Bertagnoli, Stéphane, additional, Guitton, Jean-Sébastien, additional, Le Gall-Reculé, Ghislaine, additional, Lopes, Ana Margarida, additional, Marchandeau, Stéphane, additional, Alda, Fernando, additional, Almeida, Tereza, additional, Célio, Alves Paulo, additional, Bárcena, Juan, additional, Burmakina, Galina, additional, Blanco, Esther, additional, Calvete, Carlos, additional, Cavadini, Patrizia, additional, Cooke, Brian, additional, Dalton, Kevin, additional, Delibes Mateos, Miguel, additional, Deptula, Wieslaw, additional, Eden, John Sebastian, additional, Wang, Fang, additional, Ferreira, Catarina C, additional, Ferreira, Paula, additional, Foronda, Pilar, additional, Gonçalves, David, additional, Gavier-Widén, Dolores, additional, Hall, Robin, additional, Hukowska-Szematowicz, Beata, additional, Kerr, Peter, additional, Kovaliski, John, additional, Lavazza, Antonio, additional, Mahar, Jackie, additional, Malogolovkin, Alexander, additional, Marques, Raquel M., additional, Marques, Sara, additional, Martin-Alonso, Aaron, additional, Monterroso, Pedro, additional, Moreno, Sacramento, additional, Mutze, Greg, additional, Neimanis, Aleksija, additional, Niedzwiedzka-Rystwej, Paulina, additional, Peacock, David, additional, Parra, Francisco, additional, Rocchi, Mara, additional, Rouco, Carlos, additional, Ruvoën-Clouet, Nathalie, additional, Silva, Eliane, additional, Silvério, Diogo, additional, Strive, Tanja, additional, Thompson, Gertrudes, additional, Tokarz-Deptula, Beata, additional, and Esteves, Pedro, additional

Published
2017
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23. Current strategies for subunit and genetic viral veterinary vaccine development

Author

Le Gall-Reculé, Ghislaine [0000-0003-4557-6532], Brun Torres, Alejandro, Bárcena, Juan, Blanco Lavilla, Esther, Borrego, Belén, Dory, D., Escribano, J. M., Le Gall-Reculé, Ghislaine, Ortego, Javier, Dixon, Linda, Le Gall-Reculé, Ghislaine [0000-0003-4557-6532], Brun Torres, Alejandro, Bárcena, Juan, Blanco Lavilla, Esther, Borrego, Belén, Dory, D., Escribano, J. M., Le Gall-Reculé, Ghislaine, Ortego, Javier, and Dixon, Linda

Abstract

Developing vaccines for livestock provides researchers with the opportunity to perform efficacy testing in the natural hosts. This enables the evaluation of different strategies, including definition of effective antigens or antigen combinations, and improvement in delivery systems for target antigens so that protective immune responses can be modulated or potentiated. An impressive amount of knowledge has been generated in recent years on vaccine strategies and consequently a wide variety of antigen delivery systems is now available for vaccine research. This paper reviews several antigen production and delivery strategies other than those based on the use of live viral vectors. Genetic and protein subunit vaccines as well as alternative production systems are considered in this review. © 2011 Elsevier B.V.

Published
2011

24. Emergence of Pathogenicity in Lagoviruses: Evolution from Pre-existing Nonpathogenic Strains or through a Species Jump?

Author

Esteves, Pedro José, primary, Abrantes, Joana, additional, Bertagnoli, Stéphane, additional, Cavadini, Patrizia, additional, Gavier-Widén, Dolores, additional, Guitton, Jean-Sébastien, additional, Lavazza, Antonio, additional, Lemaitre, Evelyne, additional, Letty, Jérôme, additional, Lopes, Ana Margarida, additional, Neimanis, Aleksija S., additional, Ruvoën-Clouet, Nathalie, additional, Le Pendu, Jacques, additional, Marchandeau, Stéphane, additional, and Le Gall-Reculé, Ghislaine, additional

Published
2015
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25. Caractérisation d'un nouveau variant de virus de la maladie hémorragique virale du lapin (VHD) en France

Author

Le Gall-Reculé, Ghislaine, Zwingelstein, F., Boucher, S., Le Normand, Bernadette, Bertagnoli, Stéphane, GUERIN, Jean-Luc, Portejoie, Y., Decors, Anouck, Marchandeau, S., ProdInra, Migration, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Labovet Conseil, Cabinet Vétérinaire, Interactions hôtes-agents pathogènes [Toulouse] (IHAP), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, and Office National de la Chasse et de la Faune Sauvage (ONCFS)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], nouveau variant, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2011

26. Molecular evolution and antigenic variation of European brown hare syndrome virus (EBHSV)

Author

Lopes, Ana M., primary, Capucci, Lorenzo, additional, Gavier-Widén, Dolores, additional, Le Gall-Reculé, Ghislaine, additional, Brocchi, Emiliana, additional, Barbieri, Ilaria, additional, Quéméner, Agnès, additional, Le Pendu, Jacques, additional, Geoghegan, Jemma L., additional, Holmes, Edward C., additional, Esteves, Pedro J., additional, and Abrantes, Joana, additional

Published
2014
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27. Genetic data from avian influenza and avian paramyxoviruses generated by the European network of excellence (EPIZONE) between 2006 and 2011--review and recommendations for surveillance

Author

Dundon, William G, Heidari, Alireza, Fusaro, Alice, Monne, Isabella, Beato, Maria Serena, Cattoli, Giovanni, Koch, Guus, Starick, Elke, Brown, Ian H, Aldous, Elisabeth W, Briand, François-Xavier, Le Gall-Reculé, Ghislaine, Jestin, Véronique, Jørgensen, Poul H, Berg, Mikael, Zohari, Siamak, Metreveli, Giorgi, Munir, Muhammad, Ståhl, Karl, Albina, Emmanuel, Hammoumi, Saliha, Gil, Patricia, de Almeida, Renata Servan, Smietanka, Krzysztof, Domańska-Blicharz, Katarzyna, Minta, Zenon, Van Borm, Steven, van den Berg, Thierry, Martin, Ana Moreno, Barbieri, Ilaria, Capua, Ilaria, EPIZONE Network of Excellence Molecular Epidemiology of AI, Dundon, William G, Heidari, Alireza, Fusaro, Alice, Monne, Isabella, Beato, Maria Serena, Cattoli, Giovanni, Koch, Guus, Starick, Elke, Brown, Ian H, Aldous, Elisabeth W, Briand, François-Xavier, Le Gall-Reculé, Ghislaine, Jestin, Véronique, Jørgensen, Poul H, Berg, Mikael, Zohari, Siamak, Metreveli, Giorgi, Munir, Muhammad, Ståhl, Karl, Albina, Emmanuel, Hammoumi, Saliha, Gil, Patricia, de Almeida, Renata Servan, Smietanka, Krzysztof, Domańska-Blicharz, Katarzyna, Minta, Zenon, Van Borm, Steven, van den Berg, Thierry, Martin, Ana Moreno, Barbieri, Ilaria, Capua, Ilaria, and EPIZONE Network of Excellence Molecular Epidemiology of AI

Abstract

Since 2006, the members of the molecular epidemiological working group of the European "EPIZONE" network of excellence have been generating sequence data on avian influenza and avian paramyxoviruses from both European and African sources in an attempt to more fully understand the circulation and impact of these viruses. This review presents a timely update on the epidemiological situation of these viruses based on sequence data generated during the lifetime of this project in addition to data produced by other groups during the same period. Based on this information and putting it all into a European context, recommendations for continued surveillance of these important viruses within Europe are presented.

Published
2012

29. Emergence of a new lagovirus related to rabbit haemorrhagic disease virus

Author

Le Gall-Reculé, Ghislaine, primary, Lavazza, Antonio, additional, Marchandeau, Stéphane, additional, Bertagnoli, Stéphane, additional, Zwingelstein, Françoise, additional, Cavadini, Patrizia, additional, Martinelli, Nicola, additional, Lombardi, Guerino, additional, Guérin, Jean-Luc, additional, Lemaitre, Evelyne, additional, Decors, Anouk, additional, Boucher, Samuel, additional, Le Normand, Bernadette, additional, and Capucci, Lorenzo, additional

Published
2013
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30. Histo-Blood Group Antigens Act as Attachment Factors of Rabbit Hemorrhagic Disease Virus Infection in a Virus Strain-Dependent Manner

Author

Nyström, Kristina, primary, Le Gall-Reculé, Ghislaine, additional, Grassi, Paola, additional, Abrantes, Joana, additional, Ruvoën-Clouet, Nathalie, additional, Le Moullac-Vaidye, Beatrice, additional, Lopes, Ana M., additional, Esteves, Pedro J., additional, Strive, Tanja, additional, Marchandeau, Stéphane, additional, Dell, Anne, additional, Haslam, Stuart M., additional, and Le Pendu, Jacques, additional

Published
2011
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37. Serological evidence for a non-protective RHDV-like virus.

Author

Marchandeau S, Le Gall-Reculé G, Bertagnoli S, Aubineau J, Botti G, and Lavazza A

Subjects
Animals, Animals, Wild, Antibodies, Viral analysis, Caliciviridae Infections epidemiology, Caliciviridae Infections virology, Enzyme-Linked Immunosorbent Assay veterinary, France epidemiology, Hemorrhagic Disease Virus, Rabbit genetics, Hemorrhagic Disease Virus, Rabbit immunology, Phylogeny, Seroepidemiologic Studies, Caliciviridae Infections veterinary, Disease Outbreaks veterinary, Hemorrhagic Disease Virus, Rabbit isolation & purification, Rabbits
Abstract

The data were recorded during a Rabbit haemorrhagic disease outbreak that occurred in France in 2001 in a wild population of rabbits that we have been monitoring since 2000. These data suggested the existence of non-protective antibodies due to a putative RHDV-like virus. Twenty-one blood and 22 liver samples were taken from the 26 corpses of recently dead rabbits that were found. RHDV was found in all liver samples. A first screening for RHD antibodies, carried out using an ELISA based on the detection of VP60-RHDV antigen, showed that 20 of the rabbits were seropositive. Moreover, we determined antibody titres for 13 of these 20 seropositive samples. All were > or = 1/400. Such titres normally indicate antibody levels sufficient to confer protection to all known RHDV or RHDV-like strains. For 16 samples, we determined whether these rabbits had died of a chronic or an acute form of the disease, by employing monoclonal antibody (Mabs)--based differential ELISA. All had died of an acute form of RHD. Because the antibodies detected by this VP60-ELISA test are known to appear 5-6 days after infection and since acute RHD generally kills the rabbits 2-3 days after infection, we assumed that the detected antibodies must have been present before the exposure to the virus that killed these rabbits. A second detection of antibodies was made with Mabs that are specific for RHDV. The results were negative, showing that the antibodies detected with the VP60 ELISA test were not specific for RHDV. We sequenced a portion of the VP60 gene of viruses isolated in 17 rabbits. All RHDV isolates were very similar to the RHDV strains commonly isolated in France during this period, suggesting that this viral strain was not a putative variant that is not neutralised by antibodies. Therefore we conclude that the detected antibodies were probably due to a RHDV-like virus that induces the production of detectable but non-protective antibodies.

Published
2005
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38. Muscovy duck reovirus sigmaC protein is atypically encoded by the smallest genome segment.

Author

Kuntz-Simon G, Le Gall-Reculé G, de Boisséson C, and Jestin V

Subjects
Amino Acid Sequence, Animals, Electrophoresis, Molecular Sequence Data, Orthoreovirus, Avian classification, Phylogeny, RNA, Viral analysis, Viral Proteins chemistry, Capsid Proteins, Ducks virology, Genome, Viral, Orthoreovirus, Avian genetics, Viral Proteins genetics
Abstract

Although muscovy duck reovirus (DRV) shares properties with the reovirus isolated from chicken, commonly named avian reovirus (ARV), the two virus species are antigenically different. Similar to the DRV sigmaB-encoded gene (1201 bp long) previously identified, the three other double-stranded RNA small genome segments of DRV have been cloned and sequenced. They were 1325, 1191 and 1124 bp long, respectively, and contained conserved terminal sequences common to ARVs. They coded for single expression products, except the smallest (S4), which contained two overlapping open reading frames (ORF1 and ORF2). BLAST analyses revealed that the proteins encoded by the 1325 and 1191 bp genes shared high identity levels with ARV sigmaA and sigmaNS, respectively, and to a lesser extent with other orthoreovirus counterparts. No homology was found for the S4 ORF1-encoded p10 protein. The 29.4 kDa product encoded by S4 ORF2 appeared to be 25% identical to ARV S1 ORF3-encoded sigmaC, a cell-attachment oligomer inducing type-specific neutralizing antibodies. Introduction of large gaps in the N-terminal part of the DRV protein was necessary to improve DRV and ARV sigmaC amino acid sequence alignments. However, a leucine zipper motif was conserved and secondary structure analyses predicted a three-stranded alpha-helical coiled-coil feature at this amino portion. Thus, despite extensive sequence divergence, DRV sigmaC was suggested to be structurally and probably functionally related to ARV sigmaC. This work provides evidence for the diversity of the polycistronic S class genes of reoviruses isolated from birds and raises the question of the relative classification of DRV in the Orthoreovirus genus.

Published
2002
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