8 results on '"Le Fèvre L"'
Search Results
2. Early activation of the cardiac CX3CL1/CX3CR1 axis delays β-adrenergic-induced heart failure
- Author
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Flamant, M., primary, Mougenot, N., additional, Balse, E., additional, Le Fèvre, L., additional, Atassi, F., additional, Gautier, E. L., additional, Le Goff, W., additional, Keck, M., additional, Nadaud, S., additional, Combadière, C., additional, Boissonnas, A., additional, and Pavoine, C., additional
- Published
- 2021
- Full Text
- View/download PDF
3. Déficit en sphingomyélinase acide et rupture splénique : splénectomie ou traitement conservateur ?
- Author
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Lidove, O., primary, Le Fèvre, L., additional, Goasguen, N., additional, Jamali, M., additional, Vercellino, L., additional, Garnier, M., additional, Khellaf, M., additional, Belmatoug, N., additional, and Ziza, J.-M., additional
- Published
- 2015
- Full Text
- View/download PDF
4. FX06 to rescue SARS-CoV-2-induced acute respiratory distress syndrome: a randomized clinical trial.
- Author
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Guérin E, Belin L, Franchineau G, Le Guennec L, Hajage D, Diallo MH, Frapard T, Le Fèvre L, Luyt CE, Combes A, Germain S, Hayon J, Asfar P, and Bréchot N
- Subjects
- Adult, Humans, SARS-CoV-2, Administration, Intravenous, Capillary Permeability, COVID-19 complications, Respiratory Distress Syndrome therapy
- Abstract
Background: Vascular leakage is a major feature of acute respiratory distress syndrome (ARDS). We aimed to evaluate the efficacy of FX06, a drug under development that stabilizes interendothelial cell junctions, at reducing vascular leakage during SARS-CoV-2-induced ARDS., Methods: This multicenter, double-blinded, randomized trial included adults with COVID-19-associated ARDS who had received invasive mechanical ventilation for < 5 days and were randomized to receive either intravenous FX06 (400 mg/d, for 5 days) or its vehicle as placebo. The primary endpoint was the lowering-from day 1 to day 7-of the transpulmonary thermodilution-derived extravascular lung-water index (EVLWi)., Results: Twenty-five patients were randomized to receive FX06 and 24 the placebo. Although EVLWi was elevated at baseline (median [IQR] 15.6 mL/kg [13.5; 18.5]), its declines from day 1 to day 7 were comparable for FX06 recipients and controls (respectively, - 1.9 [- 3.3; - 0.5] vs. - 0.8 [- 5.5; - 1.1] mL/kg; estimated effect - 0.8 [- 3.1; + 2.4], p = 0.51). Cardiac indexes, pulmonary vascular permeability indexes, and fluid balances were also comparable, as were PaO
2 /FiO2 ratios and durations of mechanical ventilation. Adverse event rates were similar for the 2 groups, although more FX06 recipients developed ventilator-associated pneumonia (16/25 (64%) vs. 6/24 (24%), p = 0.009)., Conclusions: In this unique-dosing-regimen study, FX06 did not lower SARS-CoV-2-induced pulmonary vascular leakage. Future investigations will need to evaluate its efficacy at earlier times during the disease or using other regimens. Trial registration NCT04618042. Registered 5 November 2020., (© 2023. BioMed Central Ltd., part of Springer Nature.)- Published
- 2023
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5. Accuracy of clinicians' ability to predict the need for renal replacement therapy: a prospective multicenter study.
- Author
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Sitbon A, Darmon M, Geri G, Jaubert P, Lamouche-Wilquin P, Monet C, Le Fèvre L, Baron M, Harlay ML, Bureau C, Joannes-Boyau O, Dupuis C, Contou D, Lemiale V, Simon M, Vinsonneau C, Blayau C, Jacobs F, and Zafrani L
- Abstract
Purpose: Identifying patients who will receive renal replacement therapy (RRT) during intensive care unit (ICU) stay is a major challenge for intensivists. The objective of this study was to evaluate the performance of physicians in predicting the need for RRT at ICU admission and at acute kidney injury (AKI) diagnosis., Methods: Prospective, multicenter study including all adult patients hospitalized in 16 ICUs in October 2020. Physician prediction was estimated at ICU admission and at AKI diagnosis, according to a visual Likert scale. Discrimination, risk stratification and benefit of physician estimation were assessed. Mixed logistic regression models of variables associated with risk of receiving RRT, with and without physician estimation, were compared., Results: Six hundred and forty-nine patients were included, 270 (41.6%) developed AKI and 77 (11.8%) received RRT. At ICU admission and at AKI diagnosis, a model including physician prediction, the experience of the physician, SOFA score, serum creatinine and diuresis to determine need for RRT performed better than a model without physician estimation with an area under the ROC curve of 0.90 [95% CI 0.86-0.94, p < 0.008 (at ICU admission)] and 0.89 [95% CI 0.83-0.93, p = 0.0014 (at AKI diagnosis)]. In multivariate analysis, physician prediction was strongly associated with the need for RRT, independently of creatinine levels, diuresis, SOFA score and the experience of the doctor who made the prediction., Conclusion: As physicians are able to stratify patients at high risk of RRT, physician judgement should be taken into account when designing new randomized studies focusing on RRT initiation during AKI., (© 2022. The Author(s).)
- Published
- 2022
- Full Text
- View/download PDF
6. Impact of rapid multiplex PCR on management of antibiotic therapy in COVID-19-positive patients hospitalized in intensive care unit.
- Author
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Maataoui N, Chemali L, Patrier J, Tran Dinh A, Le Fèvre L, Lortat-Jacob B, Marzouk M, d'Humières C, Rondinaud E, Ruppé E, Montravers P, Timsit JF, and Armand-Lefèvre L
- Subjects
- Aged, Antimicrobial Stewardship, Bacteria classification, Bacteria drug effects, Bacteria genetics, Bacterial Infections diagnosis, Bacterial Infections microbiology, COVID-19 virology, Female, Hospitalization, Humans, Intensive Care Units statistics & numerical data, Male, Middle Aged, Retrospective Studies, SARS-CoV-2 genetics, SARS-CoV-2 physiology, Anti-Bacterial Agents therapeutic use, Bacteria isolation & purification, Bacterial Infections drug therapy, COVID-19 complications, Multiplex Polymerase Chain Reaction methods
- Abstract
Because the diagnosis of co/superinfection in COVID-19 patients is challenging, empirical antibiotic therapy is frequently initiated until microbiological analysis results. We evaluated the performance and the impact of the BioFire® FilmArray® Pneumonia plus Panel on 112 respiratory samples from 67 COVID-19 ICU patients suspected of co/superinfections. Globally, the sensitivity and specificity of the test were 89.3% and 99.1%, respectively. Positive tests led to antibiotic initiation or adaptation in 15% of episodes and de-escalation in 4%. When negative, 28% of episodes remained antibiotic-free (14% no initiation, 14% withdrawal). Rapid multiplex PCRs can help to improve antibiotic stewardship by administering appropriate antibiotics earlier and avoiding unnecessary prescriptions., (© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
- Published
- 2021
- Full Text
- View/download PDF
7. Functional evidence for derivation of systemic histiocytic neoplasms from hematopoietic stem/progenitor cells.
- Author
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Durham BH, Roos-Weil D, Baillou C, Cohen-Aubart F, Yoshimi A, Miyara M, Papo M, Hélias-Rodzewicz Z, Terrones N, Ozkaya N, Dogan A, Rampal R, Urbain F, Le Fèvre L, Diamond EL, Park CY, Papo T, Charlotte F, Gorochov G, Taly V, Bernard OA, Amoura Z, Abdel-Wahab O, Lemoine FM, Haroche J, and Emile JF
- Subjects
- Adult, Alleles, Animals, Antigens, CD34 genetics, Antigens, CD34 immunology, Bone Marrow Cells immunology, Bone Marrow Transplantation, Cell Differentiation, DNA-Binding Proteins immunology, Dendritic Cells immunology, Dendritic Cells pathology, Dioxygenases, Erdheim-Chester Disease genetics, Erdheim-Chester Disease immunology, Gene Expression, Hematopoietic Stem Cells immunology, Histiocytosis, Langerhans-Cell genetics, Histiocytosis, Langerhans-Cell immunology, Humans, Immunophenotyping, Macrophages immunology, Macrophages pathology, Mice, Monocytes immunology, Monocytes pathology, Mutation, Proto-Oncogene Proteins immunology, Proto-Oncogene Proteins B-raf immunology, Transplantation, Heterologous, Bone Marrow Cells pathology, DNA-Binding Proteins genetics, Erdheim-Chester Disease pathology, Hematopoietic Stem Cells pathology, Histiocytosis, Langerhans-Cell pathology, Proto-Oncogene Proteins genetics, Proto-Oncogene Proteins B-raf genetics
- Abstract
Langerhans cell histiocytosis (LCH) and the non-LCH neoplasm Erdheim-Chester disease (ECD) are heterogeneous neoplastic disorders marked by infiltration of pathologic macrophage-, dendritic cell-, or monocyte-derived cells in tissues driven by recurrent mutations activating MAPK signaling. Although recent data indicate that at least a proportion of LCH and ECD patients have detectable activating kinase mutations in circulating hematopoietic cells and bone marrow-based hematopoietic progenitors, functional evidence of the cell of origin of histiocytosis from actual patient materials has long been elusive. Here, we provide evidence for mutations in MAPK signaling intermediates in CD34
+ cells from patients with ECD and LCH/ECD, including detection of shared origin of LCH and acute myelomonocytic leukemia driven by TET2 -mutant CD34+ cell progenitors in one patient. We also demonstrate functional self-renewal capacity for CD34+ cells to drive the development of histiocytosis in xenotransplantation assays in vivo. These data indicate that the cell of origin of at least a proportion of patients with systemic histiocytoses resides in hematopoietic progenitor cells prior to committed monocyte/macrophage or dendritic cell differentiation and provide the first example of a patient-derived xenotransplantation model for a human histiocytic neoplasm., (© 2017 by The American Society of Hematology.)- Published
- 2017
- Full Text
- View/download PDF
8. [Acid sphingomyelinase deficiency and spleen trauma: splenectomy or not splenectomy?].
- Author
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Lidove O, Le Fèvre L, Goasguen N, Jamali M, Vercellino L, Garnier M, Khellaf M, Belmatoug N, and Ziza JM
- Subjects
- Embolization, Therapeutic, Humans, Male, Middle Aged, Spleen surgery, Splenic Rupture complications, Splenomegaly complications, Splenomegaly surgery, Niemann-Pick Disease, Type B complications, Niemann-Pick Disease, Type B therapy, Spleen injuries, Splenectomy statistics & numerical data, Splenic Rupture therapy
- Abstract
Introduction: Acid sphingomyelinase deficiency leads to a severe infantile disease (Niemann-Pick disease type A) or an attenuated form of the disease encountered in adults (Niemann-Pick type B), including pulmonary fibrosis and splenomegaly., Case Report: A 52-year-old man with Niemann-Pick disease type B was admitted with splenic rupture. Embolization of the splenic artery was initially performed. Three months later, the splenic volume had increased and functional asplenia was diagnosed. Splenic scintigraphy showed 20% of functional splenic tissue. Splenectomy was finally performed because of complete necrosis of the spleen., Conclusion: Despite its theoretical contra-indication in Niemann-Pick disease due to a risk of respiratory insufficiency, splenectomy must sometimes be considered., (Copyright © 2014 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.)
- Published
- 2015
- Full Text
- View/download PDF
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