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306 results on '"Le Calvez-Kelm, Florence"'

3. Contributors

Author

Aghamir, Seyed Mohammad Kazem, primary, Ahadi, Zeinab, additional, Amirzargar, Hossein, additional, Azadvari, Mohaddeseh, additional, Fiorentino, Michelangelo, additional, Ghahestani, Seyyed Mohammad, additional, Gholami, Keykavos, additional, Guitynavard, Fateme, additional, Jahanshahi, Fatemeh, additional, Khatami, Fatemeh, additional, Khoshchehreh, Mahdi, additional, Le Calvez-Kelm, Florence, additional, Mashhadi, Rahil, additional, Rahimnia, Amirhossein, additional, Rashedi, Sina, additional, Reis, Leonardo Oliveira, additional, Rezaeian, AhmadReza, additional, Roudgari, Hassan, additional, Sheikh, Mahdi, additional, Taheri, Diana, additional, Tavoosian, Ali, additional, Yahyazadeh, Seyed Reza, additional, Yarandi, Vahid Abedi, additional, Yasseri, Alimohammad Fakhr, additional, and Zadeh, Seyed Saeed Tamehri, additional

Published
2022
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5. The association between meat and fish consumption and bladder cancer risk: a pooled analysis of 11 cohort studies

Author

Dianatinasab, Mostafa, Wesselius, Anke, de Loeij, Tessa, Salehi-Abargouei, Amin, Yu, Evan Y. W., Fararouei, Mohammad, Brinkman, Maree, van den Brandt, Piet, White, Emily, Weiderpass, Elisabete, Le Calvez-Kelm, Florence, Gunter, Marc J., Huybrechts, Inge, Liedberg, Fredrik, Skeie, Guri, Tjonneland, Anne, Riboli, Elio, and Zeegers, Maurice P.

Published
2021
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6. Hepatitis B virus preS2Δ38–55 variants: A newly identified risk factor for hepatocellular carcinoma

Author

Cohen, Damien, Ghosh, Sumantra, Shimakawa, Yusuke, Ramou, Njie, Garcia, Pierre Simon, Dubois, Anaëlle, Guillot, Clément, Kakwata-Nkor Deluce, Nora, Tilloy, Valentin, Durand, Geoffroy, Voegele, Catherine, Ndow, Gibril, d'Alessandro, Umberto, Brochier-Armanet, Céline, Alain, Sophie, Le Calvez-Kelm, Florence, Hall, Janet, Zoulim, Fabien, Mendy, Maimuna, Thursz, Mark, Lemoine, Maud, and Chemin, Isabelle

Published
2020
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7. Circulating tumour-derived KRAS mutations in pancreatic cancer cases are predominantly carried by very short fragments of cell-free DNA

Author

Zvereva, Maria, Roberti, Gabriel, Durand, Geoffroy, Voegele, Catherine, Nguyen, Minh Dao, Delhomme, Tiffany M., Chopard, Priscilia, Fabianova, Eleonora, Adamcakova, Zora, Holcatova, Ivana, Foretova, Lenka, Janout, Vladimir, Brennan, Paul, Foll, Matthieu, Byrnes, Graham B., McKay, James D., Scelo, Ghislaine, and Le Calvez-Kelm, Florence

Published
2020
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8. Vegetable intake and the risk of bladder cancer in the BLadder Cancer Epidemiology and Nutritional Determinants (BLEND) international study

Author

Yu, Evan Yi-Wen, Wesselius, Anke, Mehrkanoon, Siamak, Goosens, Mieke, Brinkman, Maree, van den Brandt, Piet, Grant, Eric J., White, Emily, Weiderpass, Elisabete, Le Calvez-Kelm, Florence, Gunter, Marc J., Huybrechts, Inge, Riboli, Elio, Tjonneland, Anne, Masala, Giovanna, Giles, Graham G., Milne, Roger L., and Zeegers, Maurice P.

Published
2021
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9. Urinary TERT promoter mutations as non-invasive biomarkers for the comprehensive detection of urothelial cancer

Author

Avogbe, Patrice Hodonou, Manel, Arnaud, Vian, Emmanuel, Durand, Geoffroy, Forey, Nathalie, Voegele, Catherine, Zvereva, Maria, Hosen, Md Ismail, Meziani, Sonia, De Tilly, Berengere, Polo, Gilles, Lole, Olesia, Francois, Pauline, Delhomme, Tiffany Myriam, Carreira, Christine, Monteiro-Reis, Sara, Henrique, Rui, Abedi-Ardekani, Behnoush, Byrnes, Graham, Foll, Matthieu, Weiderpass, Elisabete, McKay, James, Jeronimo, Carmen, Scelo, Ghislaine, and Le Calvez-Kelm, Florence

Published
2019
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11. Sex specific associations in genome wide association analysis of renal cell carcinoma

Author

Laskar, Ruhina S., Muller, David C., Li, Peng, Machiela, Mitchell J., Ye, Yuanqing, Gaborieau, Valerie, Foll, Matthieu, Hofmann, Jonathan N., Colli, Leandro, Sampson, Joshua N., Wang, Zhaoming, Bacq-Daian, Delphine, Boland, Anne, Abedi-Ardekani, Behnoush, Durand, Geoffroy, Le Calvez-Kelm, Florence, Robinot, Nivonirina, Blanche, Helene, Prokhortchouk, Egor, Skryabin, Konstantin G., Burdett, Laurie, Yeager, Meredith, Radojevic-Skodric, Sanja, Savic, Slavisa, Foretova, Lenka, Holcatova, Ivana, Janout, Vladimir, Mates, Dana, Rascu, Stefan, Mukeria, Anush, Zaridze, David, Bencko, Vladimir, Cybulski, Cezary, Fabianova, Eleonora, Jinga, Viorel, Lissowska, Jolanta, Lubinski, Jan, Navratilova, Marie, Rudnai, Peter, Świątkowska, Beata, Benhamou, Simone, Cancel-Tassin, Geraldine, Cussenot, Olivier, Trichopoulou, Antonia, Riboli, Elio, Overvad, Kim, Panico, Salvatore, Ljungberg, Borje, Sitaram, Raviprakash T., Giles, Graham G., Milne, Roger L, Severi, Gianluca, Bruinsma, Fiona, Fletcher, Tony, Koppova, Kvetoslava, Larsson, Susanna C., Wolk, Alicja, Banks, Rosamonde E., Selby, Peter J., Easton, Douglas F., Pharoah, Paul, Andreotti, Gabriella, Beane Freeman, Laura E, Koutros, Stella, Albanes, Demetrius, Männistö, Satu, Weinstein, Stephanie, Clark, Peter E., Edwards, Todd L., Lipworth, Loren, Carol, Hallie, Freedman, Matthew L., Pomerantz, Mark M., Cho, Eunyoung, Kraft, Peter, Preston, Mark A., Wilson, Kathryn M., Michael Gaziano, J., Sesso, Howard D., Black, Amanda, Freedman, Neal D., Huang, Wen-Yi, Anema, John G., Kahnoski, Richard J., Lane, Brian R., Noyes, Sabrina L., Petillo, David, Teh, Bin Tean, Peters, Ulrike, White, Emily, Anderson, Garnet L., Johnson, Lisa, Luo, Juhua, Chow, Wong-Ho, Moore, Lee E., Choueiri, Toni K., Wood, Christopher, Johansson, Mattias, McKay, James D., Brown, Kevin M., Rothman, Nathaniel, Lathrop, Mark G., Deleuze, Jean-Francois, Wu, Xifeng, Brennan, Paul, Chanock, Stephen J., Purdue, Mark P., and Scelo, Ghislaine

Published
2019
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13. DNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibility

Author

Ambatipudi, Srikant, Horvath, Steve, Perrier, Flavie, Cuenin, Cyrille, Hernandez-Vargas, Hector, Le Calvez-Kelm, Florence, Durand, Geoffroy, Byrnes, Graham, Ferrari, Pietro, Bouaoun, Liacine, Sklias, Athena, Chajes, Véronique, Overvad, Kim, Severi, Gianluca, Baglietto, Laura, Clavel-Chapelon, Françoise, Kaaks, Rudolf, Barrdahl, Myrto, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Naska, Androniki, Masala, Giovanna, Agnoli, Claudia, Polidoro, Silvia, Tumino, Rosario, Panico, Salvatore, Dollé, Martijn, Peeters, Petra H.M., Onland-Moret, N. Charlotte, Sandanger, Torkjel M., Nøst, Therese H., Weiderpass, Elisabete, Quirós, J. Ramón, Agudo, Antonio, Rodriguez-Barranco, Miguel, Huerta Castaño, José María, Barricarte, Aurelio, Fernández, Ander Matheu, Travis, Ruth C., Vineis, Paolo, Muller, David C., Riboli, Elio, Gunter, Marc, Romieu, Isabelle, and Herceg, Zdenko

Published
2017
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14. Supplementary Table 3 from Rare Mutations in RINT1 Predispose Carriers to Breast and Lynch Syndrome–Spectrum Cancers

Author

Park, Daniel J., primary, Tao, Kayoko, primary, Le Calvez-Kelm, Florence, primary, Nguyen-Dumont, Tu, primary, Robinot, Nivonirina, primary, Hammet, Fleur, primary, Odefrey, Fabrice, primary, Tsimiklis, Helen, primary, Teo, Zhi L., primary, Thingholm, Louise B., primary, Young, Erin L., primary, Voegele, Catherine, primary, Lonie, Andrew, primary, Pope, Bernard J., primary, Roane, Terrell C., primary, Bell, Russell, primary, Hu, Hao, primary, Huff, Chad D., primary, Ellis, Jonathan, primary, Li, Jun, primary, Makunin, Igor V., primary, John, Esther M., primary, Andrulis, Irene L., primary, Terry, Mary B., primary, Daly, Mary, primary, Buys, Saundra S., primary, Snyder, Carrie, primary, Lynch, Henry T., primary, Devilee, Peter, primary, Giles, Graham G., primary, Hopper, John L., primary, Feng, Bing-Jian, primary, Lesueur, Fabienne, primary, Tavtigian, Sean V., primary, Southey, Melissa C., primary, and Goldgar, David E., primary

Published
2023
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15. Supplementary Figure 1 from Rare Mutations in RINT1 Predispose Carriers to Breast and Lynch Syndrome–Spectrum Cancers

Author

Park, Daniel J., primary, Tao, Kayoko, primary, Le Calvez-Kelm, Florence, primary, Nguyen-Dumont, Tu, primary, Robinot, Nivonirina, primary, Hammet, Fleur, primary, Odefrey, Fabrice, primary, Tsimiklis, Helen, primary, Teo, Zhi L., primary, Thingholm, Louise B., primary, Young, Erin L., primary, Voegele, Catherine, primary, Lonie, Andrew, primary, Pope, Bernard J., primary, Roane, Terrell C., primary, Bell, Russell, primary, Hu, Hao, primary, Huff, Chad D., primary, Ellis, Jonathan, primary, Li, Jun, primary, Makunin, Igor V., primary, John, Esther M., primary, Andrulis, Irene L., primary, Terry, Mary B., primary, Daly, Mary, primary, Buys, Saundra S., primary, Snyder, Carrie, primary, Lynch, Henry T., primary, Devilee, Peter, primary, Giles, Graham G., primary, Hopper, John L., primary, Feng, Bing-Jian, primary, Lesueur, Fabienne, primary, Tavtigian, Sean V., primary, Southey, Melissa C., primary, and Goldgar, David E., primary

Published
2023
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16. Supplementary Table 2 from Rare Mutations in RINT1 Predispose Carriers to Breast and Lynch Syndrome–Spectrum Cancers

Author

Park, Daniel J., primary, Tao, Kayoko, primary, Le Calvez-Kelm, Florence, primary, Nguyen-Dumont, Tu, primary, Robinot, Nivonirina, primary, Hammet, Fleur, primary, Odefrey, Fabrice, primary, Tsimiklis, Helen, primary, Teo, Zhi L., primary, Thingholm, Louise B., primary, Young, Erin L., primary, Voegele, Catherine, primary, Lonie, Andrew, primary, Pope, Bernard J., primary, Roane, Terrell C., primary, Bell, Russell, primary, Hu, Hao, primary, Huff, Chad D., primary, Ellis, Jonathan, primary, Li, Jun, primary, Makunin, Igor V., primary, John, Esther M., primary, Andrulis, Irene L., primary, Terry, Mary B., primary, Daly, Mary, primary, Buys, Saundra S., primary, Snyder, Carrie, primary, Lynch, Henry T., primary, Devilee, Peter, primary, Giles, Graham G., primary, Hopper, John L., primary, Feng, Bing-Jian, primary, Lesueur, Fabienne, primary, Tavtigian, Sean V., primary, Southey, Melissa C., primary, and Goldgar, David E., primary

Published
2023
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17. Supplementary Table 1 from Rare Mutations in RINT1 Predispose Carriers to Breast and Lynch Syndrome–Spectrum Cancers

Author

Park, Daniel J., primary, Tao, Kayoko, primary, Le Calvez-Kelm, Florence, primary, Nguyen-Dumont, Tu, primary, Robinot, Nivonirina, primary, Hammet, Fleur, primary, Odefrey, Fabrice, primary, Tsimiklis, Helen, primary, Teo, Zhi L., primary, Thingholm, Louise B., primary, Young, Erin L., primary, Voegele, Catherine, primary, Lonie, Andrew, primary, Pope, Bernard J., primary, Roane, Terrell C., primary, Bell, Russell, primary, Hu, Hao, primary, Huff, Chad D., primary, Ellis, Jonathan, primary, Li, Jun, primary, Makunin, Igor V., primary, John, Esther M., primary, Andrulis, Irene L., primary, Terry, Mary B., primary, Daly, Mary, primary, Buys, Saundra S., primary, Snyder, Carrie, primary, Lynch, Henry T., primary, Devilee, Peter, primary, Giles, Graham G., primary, Hopper, John L., primary, Feng, Bing-Jian, primary, Lesueur, Fabienne, primary, Tavtigian, Sean V., primary, Southey, Melissa C., primary, and Goldgar, David E., primary

Published
2023
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18. Data from Rare Mutations in RINT1 Predispose Carriers to Breast and Lynch Syndrome–Spectrum Cancers

Author

Park, Daniel J., primary, Tao, Kayoko, primary, Le Calvez-Kelm, Florence, primary, Nguyen-Dumont, Tu, primary, Robinot, Nivonirina, primary, Hammet, Fleur, primary, Odefrey, Fabrice, primary, Tsimiklis, Helen, primary, Teo, Zhi L., primary, Thingholm, Louise B., primary, Young, Erin L., primary, Voegele, Catherine, primary, Lonie, Andrew, primary, Pope, Bernard J., primary, Roane, Terrell C., primary, Bell, Russell, primary, Hu, Hao, primary, Huff, Chad D., primary, Ellis, Jonathan, primary, Li, Jun, primary, Makunin, Igor V., primary, John, Esther M., primary, Andrulis, Irene L., primary, Terry, Mary B., primary, Daly, Mary, primary, Buys, Saundra S., primary, Snyder, Carrie, primary, Lynch, Henry T., primary, Devilee, Peter, primary, Giles, Graham G., primary, Hopper, John L., primary, Feng, Bing-Jian, primary, Lesueur, Fabienne, primary, Tavtigian, Sean V., primary, Southey, Melissa C., primary, and Goldgar, David E., primary

Published
2023
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19. MP22-19 URINARY COMPREHENSIVE GENOMIC PROFILING PREDICTS UROTHELIAL CANCER UP TO 12 YEARS AHEAD OF CLINICAL DIAGNOSIS. AN EXPANDED ANALYSIS OF THE GOLESTAN COHORT STUDY

Author

Lotan, Yair, primary, Salari, Keyan, additional, Feldman, Adam, additional, Sundi, Debasish, additional, Lee, Jason J, additional, DiFiore, Gabrielle, additional, Poustchi, Hossein, additional, Khoshnia, Masoud, additional, Roshandel, Gholamreza, additional, Etemadi, Arash, additional, Goudarzi, Mahdi, additional, Lentz, Peter S., additional, Phillips, Kevin G., additional, Bicocca, Vincent T., additional, Koppie, Theresa M., additional, Gray, Joe W., additional, Levin, Trevor, additional, Malekzadeh, Reza, additional, Sheikh, Mahdi, additional, and Le Calvez-Kelm, Florence, additional

Published
2023
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20. Data from Genome-Wide DNA Methylation Profiling of Esophageal Squamous Cell Carcinoma from Global High-Incidence Regions Identifies Crucial Genes and Potential Cancer Markers

Author

Talukdar, Fazlur Rahman, primary, Soares Lima, Sheila C., primary, Khoueiry, Rita, primary, Laskar, Ruhina Shirin, primary, Cuenin, Cyrille, primary, Sorroche, Bruna Pereira, primary, Boisson, Anne-Claire, primary, Abedi-Ardekani, Behnoush, primary, Carreira, Christine, primary, Menya, Diana, primary, Dzamalala, Charles P., primary, Assefa, Mathewos, primary, Aseffa, Abraham, primary, Miranda-Gonçalves, Vera, primary, Jerónimo, Carmen, primary, Henrique, Rui M., primary, Shakeri, Ramin, primary, Malekzadeh, Reza, primary, Gasmelseed, Nagla, primary, Ellaithi, Mona, primary, Gangane, Nitin, primary, Middleton, Daniel R.S., primary, Le Calvez-Kelm, Florence, primary, Ghantous, Akram, primary, Roux, Maria Leon, primary, Schüz, Joachim, primary, McCormack, Valerie, primary, Parker, M. Iqbal, primary, Pinto, Luis Felipe Ribeiro, primary, and Herceg, Zdenko, primary

Published
2023
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21. Supplementary Data from Genome-Wide DNA Methylation Profiling of Esophageal Squamous Cell Carcinoma from Global High-Incidence Regions Identifies Crucial Genes and Potential Cancer Markers

Author

Talukdar, Fazlur Rahman, primary, Soares Lima, Sheila C., primary, Khoueiry, Rita, primary, Laskar, Ruhina Shirin, primary, Cuenin, Cyrille, primary, Sorroche, Bruna Pereira, primary, Boisson, Anne-Claire, primary, Abedi-Ardekani, Behnoush, primary, Carreira, Christine, primary, Menya, Diana, primary, Dzamalala, Charles P., primary, Assefa, Mathewos, primary, Aseffa, Abraham, primary, Miranda-Gonçalves, Vera, primary, Jerónimo, Carmen, primary, Henrique, Rui M., primary, Shakeri, Ramin, primary, Malekzadeh, Reza, primary, Gasmelseed, Nagla, primary, Ellaithi, Mona, primary, Gangane, Nitin, primary, Middleton, Daniel R.S., primary, Le Calvez-Kelm, Florence, primary, Ghantous, Akram, primary, Roux, Maria Leon, primary, Schüz, Joachim, primary, McCormack, Valerie, primary, Parker, M. Iqbal, primary, Pinto, Luis Felipe Ribeiro, primary, and Herceg, Zdenko, primary

Published
2023
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22. Supplementary Figure S2 from Low-Coverage Exome Sequencing Screen in Formalin-Fixed Paraffin-Embedded Tumors Reveals Evidence of Exposure to Carcinogenic Aristolochic Acid

Author

Castells, Xavier, primary, Karanović, Sandra, primary, Ardin, Maude, primary, Tomić, Karla, primary, Xylinas, Evanguelos, primary, Durand, Geoffroy, primary, Villar, Stephanie, primary, Forey, Nathalie, primary, Le Calvez-Kelm, Florence, primary, Voegele, Catherine, primary, Karlović, Krešimir, primary, Mišić, Maja, primary, Dittrich, Damir, primary, Dolgalev, Igor, primary, McKay, James, primary, Shariat, Shahrokh F., primary, Sidorenko, Viktoria S., primary, Fernandes, Andrea, primary, Heguy, Adriana, primary, Dickman, Kathleen G., primary, Olivier, Magali, primary, Grollman, Arthur P., primary, Jelaković, Bojan, primary, and Zavadil, Jiri, primary

Published
2023
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23. Supplemental Material (for review only) File - Supplementary Tables 1-5. from Low-Coverage Exome Sequencing Screen in Formalin-Fixed Paraffin-Embedded Tumors Reveals Evidence of Exposure to Carcinogenic Aristolochic Acid

Author

Castells, Xavier, primary, Karanović, Sandra, primary, Ardin, Maude, primary, Tomić, Karla, primary, Xylinas, Evanguelos, primary, Durand, Geoffroy, primary, Villar, Stephanie, primary, Forey, Nathalie, primary, Le Calvez-Kelm, Florence, primary, Voegele, Catherine, primary, Karlović, Krešimir, primary, Mišić, Maja, primary, Dittrich, Damir, primary, Dolgalev, Igor, primary, McKay, James, primary, Shariat, Shahrokh F., primary, Sidorenko, Viktoria S., primary, Fernandes, Andrea, primary, Heguy, Adriana, primary, Dickman, Kathleen G., primary, Olivier, Magali, primary, Grollman, Arthur P., primary, Jelaković, Bojan, primary, and Zavadil, Jiri, primary

Published
2023
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24. Figures from Genome-Wide DNA Methylation Profiling of Esophageal Squamous Cell Carcinoma from Global High-Incidence Regions Identifies Crucial Genes and Potential Cancer Markers

Author

Talukdar, Fazlur Rahman, primary, Soares Lima, Sheila C., primary, Khoueiry, Rita, primary, Laskar, Ruhina Shirin, primary, Cuenin, Cyrille, primary, Sorroche, Bruna Pereira, primary, Boisson, Anne-Claire, primary, Abedi-Ardekani, Behnoush, primary, Carreira, Christine, primary, Menya, Diana, primary, Dzamalala, Charles P., primary, Assefa, Mathewos, primary, Aseffa, Abraham, primary, Miranda-Gonçalves, Vera, primary, Jerónimo, Carmen, primary, Henrique, Rui M., primary, Shakeri, Ramin, primary, Malekzadeh, Reza, primary, Gasmelseed, Nagla, primary, Ellaithi, Mona, primary, Gangane, Nitin, primary, Middleton, Daniel R.S., primary, Le Calvez-Kelm, Florence, primary, Ghantous, Akram, primary, Roux, Maria Leon, primary, Schüz, Joachim, primary, McCormack, Valerie, primary, Parker, M. Iqbal, primary, Pinto, Luis Felipe Ribeiro, primary, and Herceg, Zdenko, primary

Published
2023
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25. Supplementary Methods from Low-Coverage Exome Sequencing Screen in Formalin-Fixed Paraffin-Embedded Tumors Reveals Evidence of Exposure to Carcinogenic Aristolochic Acid

Author

Castells, Xavier, primary, Karanović, Sandra, primary, Ardin, Maude, primary, Tomić, Karla, primary, Xylinas, Evanguelos, primary, Durand, Geoffroy, primary, Villar, Stephanie, primary, Forey, Nathalie, primary, Le Calvez-Kelm, Florence, primary, Voegele, Catherine, primary, Karlović, Krešimir, primary, Mišić, Maja, primary, Dittrich, Damir, primary, Dolgalev, Igor, primary, McKay, James, primary, Shariat, Shahrokh F., primary, Sidorenko, Viktoria S., primary, Fernandes, Andrea, primary, Heguy, Adriana, primary, Dickman, Kathleen G., primary, Olivier, Magali, primary, Grollman, Arthur P., primary, Jelaković, Bojan, primary, and Zavadil, Jiri, primary

Published
2023
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26. Supplementary Figure legends from Low-Coverage Exome Sequencing Screen in Formalin-Fixed Paraffin-Embedded Tumors Reveals Evidence of Exposure to Carcinogenic Aristolochic Acid

Author

Castells, Xavier, primary, Karanović, Sandra, primary, Ardin, Maude, primary, Tomić, Karla, primary, Xylinas, Evanguelos, primary, Durand, Geoffroy, primary, Villar, Stephanie, primary, Forey, Nathalie, primary, Le Calvez-Kelm, Florence, primary, Voegele, Catherine, primary, Karlović, Krešimir, primary, Mišić, Maja, primary, Dittrich, Damir, primary, Dolgalev, Igor, primary, McKay, James, primary, Shariat, Shahrokh F., primary, Sidorenko, Viktoria S., primary, Fernandes, Andrea, primary, Heguy, Adriana, primary, Dickman, Kathleen G., primary, Olivier, Magali, primary, Grollman, Arthur P., primary, Jelaković, Bojan, primary, and Zavadil, Jiri, primary

Published
2023
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27. Data from Low-Coverage Exome Sequencing Screen in Formalin-Fixed Paraffin-Embedded Tumors Reveals Evidence of Exposure to Carcinogenic Aristolochic Acid

Author

Castells, Xavier, primary, Karanović, Sandra, primary, Ardin, Maude, primary, Tomić, Karla, primary, Xylinas, Evanguelos, primary, Durand, Geoffroy, primary, Villar, Stephanie, primary, Forey, Nathalie, primary, Le Calvez-Kelm, Florence, primary, Voegele, Catherine, primary, Karlović, Krešimir, primary, Mišić, Maja, primary, Dittrich, Damir, primary, Dolgalev, Igor, primary, McKay, James, primary, Shariat, Shahrokh F., primary, Sidorenko, Viktoria S., primary, Fernandes, Andrea, primary, Heguy, Adriana, primary, Dickman, Kathleen G., primary, Olivier, Magali, primary, Grollman, Arthur P., primary, Jelaković, Bojan, primary, and Zavadil, Jiri, primary

Published
2023
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28. First Molecular Characterization of Chronic Hepatitis B Carriers in Timbuktu, Mali

Author

Lawrence, Philip, primary, Chabane, Mawlouda, additional, Abrouk, Lucie, additional, Thiesson, Adrien, additional, Berthé, Diakaridia, additional, Diarra, Amadou B., additional, Bengaly, Karim, additional, Traoré, Brehima, additional, Kassogué, Djibril, additional, Durand, Geoffroy, additional, Voegele, Catherine, additional, Le Calvez-Kelm, Florence, additional, Steenkeste, Nicolas, additional, Hainaut, Pierre, additional, Kouriba, Bourema, additional, and Gormally, Emmanuelle, additional

Published
2023
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29. CASP9 germline mutation in a family with multiple brain tumors

Author

Ronellenfitsch, Michael W., Oh, Ji‐Eun, Satomi, Kaishi, Sumi, Koichiro, Harter, Patrick N., Steinbach, Joachim P., Felsberg, Jörg, Capper, David, Voegele, Catherine, Durand, Geoffroy, McKay, James, Le Calvez‐Kelm, Florence, Schittenhelm, Jens, Klink, Barbara, Mittelbronn, Michel, and Ohgaki, Hiroko

Published
2018
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30. Sexual dimorphism in cancer: insights from transcriptional signatures in kidney tissue and renal cell carcinoma

Author

Laskar, Ruhina S, Li, Peng, Ecsedi, Szilvia, Abedi-Ardekani, Behnoush, Durand, Geoffroy, Robinot, Nivonirina, Hubert, Jean-Noël, Janout, Vladimir, Zaridze, David, Mukeria, Anush, Mates, Dana, Holcatova, Ivana, Foretova, Lenka, Swiatkowska, Beata, Dzamic, Zoran, Milosavljevic, Sasa, Olaso, Robert, Boland, Anne, Deleuze, Jean-François, Muller, David C, McKay, James D, Brennan, Paul, Le Calvez-Kelm, Florence, Scelo, Ghislaine, and Chanudet, Estelle

Subjects
AcademicSubjects/SCI01140, Male, Sex Characteristics, Gene Expression Profiling, Middle Aged, Prognosis, Kidney Neoplasms, Gene Expression Regulation, Neoplastic, Genes, X-Linked, Biomarkers, Tumor, Disease Progression, Humans, Female, Genes, Tumor Suppressor, Genetic Predisposition to Disease, General Article, Carcinoma, Renal Cell, Genetic Association Studies, Aged, Genome-Wide Association Study
Abstract

Sexual dimorphism in cancer incidence and outcome is widespread. Understanding the underlying mechanisms is fundamental to improve cancer prevention and clinical management. Sex disparities are particularly striking in kidney cancer: across diverse populations, men consistently show unexplained 2-fold increased incidence and worse prognosis. We have characterized genome-wide expression and regulatory networks of 609 renal tumors and 256 non-tumor renal tissues. Normal kidney displayed sex-specific transcriptional signatures, including higher expression of X-linked tumor suppressor genes in women. Sex-dependent genotype–phenotype associations unraveled women-specific immune regulation. Sex differences were markedly expanded in tumors, with male-biased expression of key genes implicated in metabolism, non-malignant diseases with male predominance and carcinogenesis, including markers of tumor infiltrating leukocytes. Analysis of sex-dependent RCC progression and survival uncovered prognostic markers involved in immune response and oxygen homeostasis. In summary, human kidney tissues display remarkable sexual dimorphism at the molecular level. Sex-specific transcriptional signatures further shape renal cancer, with relevance for clinical management.

Published
2021

35. Detection of Circulating HPV16 DNA as a Biomarker for Cervical Cancer by a Bead-Based HPV Genotyping Assay

Author

Galati, Luisa, primary, Combes, Jean-Damien, additional, Le Calvez-Kelm, Florence, additional, McKay-Chopin, Sandrine, additional, Forey, Nathalie, additional, Ratel, Mathis, additional, McKay, James, additional, Waterboer, Tim, additional, Schroeder, Lea, additional, Clifford, Gary, additional, Tommasino, Massimo, additional, and Gheit, Tarik, additional

Published
2022
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36. Dietary fats and their sources in association with the risk of bladder cancer: A pooled analysis of 11 prospective cohort studies

Author

Dianatinasab, Mostafa, primary, Wesselius, Anke, additional, Salehi‐Abargouei, Amin, additional, Yu, Evan Y. W., additional, Fararouei, Mohammad, additional, Brinkman, Maree, additional, van den Brandt, Piet, additional, White, Emily, additional, Weiderpass, Elisabete, additional, Le Calvez‐Kelm, Florence, additional, Gunter, Marc J., additional, Huybrechts, Inge, additional, and Zeegers, Maurice P., additional

Published
2022
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37. Development of a custom next-generation sequencing panel for the determination of bladder cancer risk in a Tunisian cohort

Author

Hemissi, Imen, primary, Boussetta, Sami, additional, Dallali, Hamza, additional, Hellal, Faycel, additional, Durand, Geoffroy, additional, Voegele, Catherine, additional, Ayed, Haroun, additional, Zaghbib, Selim, additional, Naimi, Zeineb, additional, Ayadi, Mouna, additional, Chebil, Mohamed, additional, Mckay, James, additional, Le Calvez-Kelm, Florence, additional, and Ouerhani, Slah, additional

Published
2021
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38. Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer

Author

Wang, Yufei, McKay, James D, Rafnar, Thorunn, Wang, Zhaoming, Timofeeva, Maria N, Broderick, Peter, Zong, Xuchen, Laplana, Marina, Wei, Yongyue, Han, Younghun, Lloyd, Amy, Delahaye-Sourdeix, Manon, Chubb, Daniel, Gaborieau, Valerie, Wheeler, William, Chatterjee, Nilanjan, Thorleifsson, Gudmar, Sulem, Patrick, Liu, Geoffrey, Kaaks, Rudolf, Henrion, Marc, Kinnersley, Ben, Vallée, Maxime, Le Calvez-Kelm, Florence, Stevens, Victoria L, Gapstur, Susan M, Chen, Wei V, Zaridze, David, Szeszenia-Dabrowska, Neonilia, Lissowska, Jolanta, Rudnai, Peter, Fabianova, Eleonora, Mates, Dana, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Krokan, Hans E, Gabrielsen, Maiken Elvestad, Skorpen, Frank, Vatten, Lars, Njølstad, Inger, Chen, Chu, Goodman, Gary, Benhamou, Simone, Vooder, Tonu, Välk, Kristjan, Nelis, Mari, Metspalu, Andres, Lener, Marcin, Lubiński, Jan, Johansson, Mattias, Vineis, Paolo, Agudo, Antonio, Clavel-Chapelon, Francoise, Bueno-de-Mesquita, H Bas, Trichopoulos, Dimitrios, Khaw, Kay-Tee, Johansson, Mikael, Weiderpass, Elisabete, Tjønneland, Anne, Riboli, Elio, Lathrop, Mark, Scelo, Ghislaine, Albanes, Demetrius, Caporaso, Neil E, Ye, Yuanqing, Gu, Jian, Wu, Xifeng, Spitz, Margaret R, Dienemann, Hendrik, Rosenberger, Albert, Su, Li, Matakidou, Athena, Eisen, Timothy, Stefansson, Kari, Risch, Angela, Chanock, Stephen J, Christiani, David C, Hung, Rayjean J, Brennan, Paul, Landi, Maria Teresa, Houlston, Richard S, and Amos, Christopher I

Published
2014
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39. No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing

Author

Easton, Douglas F, Lesueur, Fabienne, Decker, Brennan, Michailidou, Kyriaki, Li, Jun, Allen, Jamie, Luccarini, Craig, Pooley, Karen A, Shah, Mitul, Bolla, Manjeet K, Wang, Qin, Dennis, Joe, Ahmad, Jamil, Thompson, Ella R, Damiola, Francesca, Pertesi, Maroulio, Voegele, Catherine, Mebirouk, Noura, Robinot, Nivonirina, Durand, Geoffroy, Forey, Nathalie, Luben, Robert N, Ahmed, Shahana, Aittomäki, Kristiina, Anton-Culver, Hoda, Arndt, Volker, Baynes, Caroline, Beckman, Matthias W, Benitez, Javier, Van Den Berg, David, Blot, William J, Bogdanova, Natalia V, Bojesen, Stig E, Brenner, Hermann, Chang-Claude, Jenny, Chia, Kee Seng, Choi, Ji-Yeob, Conroy, Don M, Cox, Angela, Cross, Simon S, Czene, Kamila, Darabi, Hatef, Devilee, Peter, Eriksson, Mikael, Fasching, Peter A, Figueroa, Jonine, Flyger, Henrik, Fostira, Florentia, García-Closas, Montserrat, Giles, Graham G, Glendon, Gord, González-Neira, Anna, Guénel, Pascal, Haiman, Christopher A, Hall, Per, Hart, Steven N, Hartman, Mikael, Hooning, Maartje J, Hsiung, Chia-Ni, Ito, Hidemi, Jakubowska, Anna, James, Paul A, John, Esther M, Johnson, Nichola, Jones, Michael, Kabisch, Maria, Kang, Daehee, Kosma, Veli-Matti, Kristensen, Vessela, Lambrechts, Diether, Li, Na, Lindblom, Annika, Long, Jirong, Lophatananon, Artitaya, Lubinski, Jan, Mannermaa, Arto, Manoukian, Siranoush, Margolin, Sara, Matsuo, Keitaro, Meindl, Alfons, Mitchell, Gillian, Muir, Kenneth, Nevelsteen, Ines, van den Ouweland, Ans, Peterlongo, Paolo, Phuah, Sze Yee, Pylkäs, Katri, Rowley, Simone M, Sangrajrang, Suleeporn, Schmutzler, Rita K, Shen, Chen-Yang, Shu, Xiao-Ou, Southey, Melissa C, Surowy, Harald, Swerdlow, Anthony, Teo, Soo H, Tollenaar, Rob A E M, Tomlinson, Ian, Torres, Diana, Truong, Thérèse, Vachon, Celine, Verhoef, Senno, Wong-Brown, Michelle, Zheng, Wei, Zheng, Ying, Nevanlinna, Heli, Scott, Rodney J, Andrulis, Irene L, Wu, Anna H, Hopper, John L, Couch, Fergus J, Winqvist, Robert, Burwinkel, Barbara, Sawyer, Elinor J, Schmidt, Marjanka K, Rudolph, Anja, Dörk, Thilo, Brauch, Hiltrud, Hamann, Ute, Neuhausen, Susan L, Milne, Roger L, Fletcher, Olivia, Pharoah, Paul D P, Campbell, Ian G, Dunning, Alison M, Le Calvez-Kelm, Florence, Goldgar, David E, Tavtigian, Sean V, and Chenevix-Trench, Georgia

Published
2016
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42. Epigenetic remodelling of enhancers in response to estrogen deprivation and re-stimulation

Author

Sklias, Athena, primary, Halaburkova, Andrea, additional, Vanzan, Ludovica, additional, Jimenez, Nora Fernandez, additional, Cuenin, Cyrille, additional, Bouaoun, Liacine, additional, Cahais, Vincent, additional, Ythier, Victor, additional, Sallé, Aurélie, additional, Renard, Claire, additional, Durand, Geoffroy, additional, Le Calvez-Kelm, Florence, additional, Khoueiry, Rita, additional, Murr, Rabih, additional, and Herceg, Zdenko, additional

Published
2021
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43. Epigenetic remodelling of enhancers in response to estrogen deprivation and re-stimulation

Author

Genética, antropología física y fisiología animal, Genetika,antropologia fisikoa eta animalien fisiologia, Sklias, Athena, Halaburkova, Andrea, Vanzan, Ludovica, Fernández Jiménez, Nora, Cuenin, Cyrille, Bouaoun, Liacine, Cahais, Vincent, Ythier, Victor, Salle, Aurelie, Renard, Claire, Durand, Geoffroy, Le Calvez Kelm, Florence, Khoueiry, Rita, Murr, Rabih, Herceg, Zdenko, Genética, antropología física y fisiología animal, Genetika,antropologia fisikoa eta animalien fisiologia, Sklias, Athena, Halaburkova, Andrea, Vanzan, Ludovica, Fernández Jiménez, Nora, Cuenin, Cyrille, Bouaoun, Liacine, Cahais, Vincent, Ythier, Victor, Salle, Aurelie, Renard, Claire, Durand, Geoffroy, Le Calvez Kelm, Florence, Khoueiry, Rita, Murr, Rabih, and Herceg, Zdenko

Abstract

Estrogen hormones are implicated in a majority of breast cancers and estrogen receptor alpha (ER), the main nuclear factor mediating estrogen signaling, orchestrates a complex molecular circuitry that is not yet fully elucidated. Here, we investigated genome-wide DNA methylation, histone acetylation and transcription after estradiol (E2) deprivation and re-stimulation to better characterize the ability of ER to coordinate gene regulation. We found that E2 deprivation mostly resulted in DNA hypermethylation and histone deacetylation in enhancers. Transcriptome analysis revealed that E2 deprivation leads to a global down-regulation in gene expression, and more specifically of TET2 demethylase that may be involved in the DNA hypermethylation following short-term E2 deprivation. Further enrichment analysis of transcription factor (TF) binding and motif occurrence highlights the importance of ER connection mainly with two partner TF families, AP-1 and FOX. Theseinteractions takeplace in the proximity of E2 deprivation-mediated differentially methylated and histone acetylated enhancers. Finally, while most deprivation-dependent epigenetic changes were reversed following E2 re-stimulation, DNA hypermethylation and H3K27 deacetylation at certain enhancers were partially retained. Overall, these results show that inactivation of ER mediates rapid and mostly reversible epigenetic changes at enhancers, and bring new insight into early events, which may ultimately lead to endocrine resistance.

Published
2021

44. Risk prediction for renal cell Carcinoma: Results from the European Prospective Investigation into Cancer and nutrition (EPIC) prospective cohort study

Author

Singleton, Rosie K., Heath, Alicia K., Clasen, Joanna L., Scelo, Ghislaine, Johansson, Mattias, Le Calvez-Kelm, Florence, Weiderpass, Elisabete, Liedberg, Fredrik, Ljungberg, Börje, Harbs, Justin, Olsen, Anja, Tjønneland, Anne, Dahm, Christina C., Kaaks, Rudolf, Fortner, Renee T., Panico, Salvatore, Tagliabue, Giovanna, Masala, Giovanna, Tumino, Rosario, Ricceri, Fulvio, Gram, Inger T., Santiuste, Carmen, Bonet, Catalina, Rodriguez-Barranco, Miguel, Schulze, Mattias B., Bergmann, Manuela M., Travis, Ruth C., Tzoulaki, Ioanna, Riboli, Elio, Muller, David C., Singleton, Rosie K., Heath, Alicia K., Clasen, Joanna L., Scelo, Ghislaine, Johansson, Mattias, Le Calvez-Kelm, Florence, Weiderpass, Elisabete, Liedberg, Fredrik, Ljungberg, Börje, Harbs, Justin, Olsen, Anja, Tjønneland, Anne, Dahm, Christina C., Kaaks, Rudolf, Fortner, Renee T., Panico, Salvatore, Tagliabue, Giovanna, Masala, Giovanna, Tumino, Rosario, Ricceri, Fulvio, Gram, Inger T., Santiuste, Carmen, Bonet, Catalina, Rodriguez-Barranco, Miguel, Schulze, Mattias B., Bergmann, Manuela M., Travis, Ruth C., Tzoulaki, Ioanna, Riboli, Elio, and Muller, David C.

Abstract

Background: Early detection of renal cell carcinoma (RCC) has the potential to improve disease outcomes. No screening program for sporadic RCC is in place. Given relatively low incidence, screening would need to focus on people at high risk of clinically meaningful disease so as to limit overdiagnosis and screen-detected false positives. Methods: Among 192,172 participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (including 588 incident RCC cases), we evaluated a published RCC risk prediction model (including age, sex, BMI, and smoking status) in terms of discrimination (C-statistic) and calibration (observed probability as a function of predicted probability). We used a flexible parametric survival model to develop an expanded model including age, sex, BMI, and smoking status, with the addition of self-reported history of hypertension and measured blood pressure. Results: The previously published model yielded well-calibrated probabilities and good discrimination (C-statistic [95% CI]: 0.699 [0.679–0.721]). Our model had slightly improved discrimination (0.714 [0.694–0.735], bootstrap optimism-corrected C-statistic: 0.709). Despite this good performance, predicted risk was low for the vast majority of participants, with 70% of participants having 10-year risk less than 0.0025. Conclusions: Although the models performed well for the prediction of incident RCC, they are currently insufficiently powerful to identify individuals at substantial risk of RCC in a general population. Impact: Despite the promising performance of the EPIC RCC risk prediction model, further development of the model, possibly including biomarkers of risk, is required to enable risk stratification of RCC.

Published
2021
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45. The association between meat and fish consumption and bladder cancer risk:a pooled analysis of 11 cohort studies

Author

Dianatinasab, Mostafa, Wesselius, Anke, de Loeij, Tessa, Salehi-Abargouei, Amin, Yu, Evan Y. W., Fararouei, Mohammad, Brinkman, Maree, van den Brandt, Piet, White, Emily, Weiderpass, Elisabete, Le Calvez-Kelm, Florence, Gunter, Marc J., Huybrechts, Inge, Liedberg, Fredrik, Skeie, Guri, Tjonneland, Anne, Riboli, Elio, Zeegers, Maurice P., Dianatinasab, Mostafa, Wesselius, Anke, de Loeij, Tessa, Salehi-Abargouei, Amin, Yu, Evan Y. W., Fararouei, Mohammad, Brinkman, Maree, van den Brandt, Piet, White, Emily, Weiderpass, Elisabete, Le Calvez-Kelm, Florence, Gunter, Marc J., Huybrechts, Inge, Liedberg, Fredrik, Skeie, Guri, Tjonneland, Anne, Riboli, Elio, and Zeegers, Maurice P.

Abstract

Evidence on the effects of meat consumption from different sources on the risk of bladder cancer (BC) is limited and controversial. Therefore, this study aimed to evaluate the associations between meat consumption and BC risk using a pooled data approach. Individual data from 11 prospective cohorts comprising 2848 BC cases and 515,697 non-cases with a total of 5,498,025 person-years of follow-up was pooled and analysed to investigate the potential associations between total red meat and products, red meat, processed meat, poultry and total fish and BC risk. Hazard ratios (HRs), with corresponding 95% confidence intervals (CIs), were estimated using Cox regression models stratified on cohort. Overall, an increased BC risk was found for high intake of organ meat (HR comparing highest with lowest tertile: 1.18, 95% CI: 1.03, 1.36, p-trend = 0.03). On the contrary, a marginally inverse association was observed for total fish intake and BC risk among men (HR comparing highest with lowest tertile: 0.79, 95% CI 0.65, 0.97, p-trend = 0.04). No associations were observed for other meat sources. Results of this prospective study suggest that organ meat consumption may be associated with BC development. Replication in large-scale prospective studies and investigation of possible causal mechanisms is needed.

Published
2021

46. Risk Prediction for Renal Cell Carcinoma:Results from the European Prospective Investigation into Cancer and Nutrition (EPIC) Prospective Cohort Study

Author

Singleton, Rosie K., Heath, Alicia K., Clasen, Joanna L., Scelo, Ghislaine, Johansson, Mattias, Le Calvez-Kelm, Florence, Weiderpass, Elisabete, Liedberg, Fredrik, Ljungberg, Borje, Harbs, Justin, Olsen, Anja, Tjonneland, Anne, Dahm, Christina C., Kaaks, Rudolf, Fortner, Renee T., Panico, Salvatore, Tagliabue, Giovanna, Masala, Giovanna, Tumino, Rosario, Ricceri, Fulvio, Gram, Inger T., Santiuste, Carmen, Bonet, Catalina, Rodriguez-Barranco, Miguel, Schulze, Mattias B., Bergmann, Manuela M., Travis, Ruth C., Tzoulaki, Ioanna, Riboli, Elio, Muller, David C., Singleton, Rosie K., Heath, Alicia K., Clasen, Joanna L., Scelo, Ghislaine, Johansson, Mattias, Le Calvez-Kelm, Florence, Weiderpass, Elisabete, Liedberg, Fredrik, Ljungberg, Borje, Harbs, Justin, Olsen, Anja, Tjonneland, Anne, Dahm, Christina C., Kaaks, Rudolf, Fortner, Renee T., Panico, Salvatore, Tagliabue, Giovanna, Masala, Giovanna, Tumino, Rosario, Ricceri, Fulvio, Gram, Inger T., Santiuste, Carmen, Bonet, Catalina, Rodriguez-Barranco, Miguel, Schulze, Mattias B., Bergmann, Manuela M., Travis, Ruth C., Tzoulaki, Ioanna, Riboli, Elio, and Muller, David C.

Abstract

Background: Early detection of renal cell carcinoma (RCC) has the potential to improve disease outcomes. No screening program for sporadic RCC is in place. Given relatively low incidence, screening would need to focus on people at high risk of clinically meaningful disease so as to limit overdiagnosis and screen-detected false positives.Methods: Among 192,172 participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (including 588 incident RCC cases), we evaluated a published RCC risk prediction model (including age, sex, BMI, and smoking status) in terms of discrimination (C-statistic) and calibration (observed probability as a function of predicted probability). We used a flexible parametric survival model to develop an expanded model including age, sex, BMI, and smoking status, with the addition of self-reported history of hypertension and measured blood pressure.Results: The previously published model yielded well-calibrated probabilities and good discrimination (C-statistic [95% CI]: 0.699 [0.679-0.721]). Our model had slightly improved discrimination (0.714 [0.694-0.735], bootstrap optimism-corrected C-statistic: 0.709). Despite this good performance, predicted risk was low for the vast majority of participants, with 70% of participants having 10-year risk less than 0.0025.Conclusions: Although the models performed well for the prediction of incident RCC, they are currently insufficiently powerful to identify individuals at substantial risk of RCC in a general population.Impact: Despite the promising performance of the EPIC RCC risk prediction model, further development of the model, possibly including biomarkers of risk, is required to enable risk stratification of RCC.

Published
2021

48. Rare, evolutionarily unlikely missense substitutions in ATM Confer increased risk of breast cancer

Author

Tavtigian, Sean V., Oefner, Peter J., Babikyan, Davit, Hartmann, Anne, Chenevix-Trench, Georgia, John, Esther M., Healey, Sue, Le Calvez-Kelm, Florence, Lesueur, Fabienne, Andrulis, Irene L., Southey, Melissa C., Byrnes, Graham B., Shu-Chun Chuang, Forey, Nathalie, Voegele, Catherine, Webb, Penelope M., Feuchtinger, Corinna, Gioia, Lydie, Hall, Janet, Hashibe, Mia, Whitemanv, David C., Sangrajrang, Suleeporn, Herte, Barbara, McKay-Chopin, Sandrine, Thomas, Alun, Vallee, Maxime P., and Hopper, John L.

Subjects
Gene mutations -- Analysis, Human evolution -- Analysis, Ataxia telangiectasia -- Genetic aspects, Ataxia telangiectasia -- Research, Breast cancer -- Risk factors, Biological sciences
Abstract

Several case-studies are conducted to explain the rare and evolutionary ATM (ataxia telangiectasia [MIM 208900]) mutations, which usually lead to increase risk of breast cancer in humans. The breast cancer risk is shown to be highly enhanced by the protein-truncating and splice-junction variants of the ATM mutations.

Published
2009

49. Genome-Wide DNA Methylation Profiling of Esophageal Squamous Cell Carcinoma from Global High-Incidence Regions Identifies Crucial Genes and Potential Cancer Markers

Author

Talukdar, Fazlur Rahman, primary, Soares Lima, Sheila C., additional, Khoueiry, Rita, additional, Laskar, Ruhina Shirin, additional, Cuenin, Cyrille, additional, Sorroche, Bruna Pereira, additional, Boisson, Anne-Claire, additional, Abedi-Ardekani, Behnoush, additional, Carreira, Christine, additional, Menya, Diana, additional, Dzamalala, Charles P., additional, Assefa, Mathewos, additional, Aseffa, Abraham, additional, Miranda-Gonçalves, Vera, additional, Jerónimo, Carmen, additional, Henrique, Rui M., additional, Shakeri, Ramin, additional, Malekzadeh, Reza, additional, Gasmelseed, Nagla, additional, Ellaithi, Mona, additional, Gangane, Nitin, additional, Middleton, Daniel R.S., additional, Le Calvez-Kelm, Florence, additional, Ghantous, Akram, additional, Roux, Maria Leon, additional, Schüz, Joachim, additional, McCormack, Valerie, additional, Parker, M. Iqbal, additional, Pinto, Luis Felipe Ribeiro, additional, and Herceg, Zdenko, additional

Published
2021
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50. Grain and dietary fiber intake and bladder cancer risk:a pooled analysis of prospective cohort studies

Author

Yu, Evan Y.W., Wesselius, Anke, Mehrkanoon, Siamak, Brinkman, Maree, van den Brandt, Piet, White, Emily, Weiderpass, Elisabete, Le Calvez-Kelm, Florence, Gunter, Marc, Huybrechts, Inge, Liedberg, Fredrik, Skeie, Guri, Tjonneland, Anne, Riboli, Elio, Giles, Graham G., Milne, Roger L., Zeegers, Maurice P., Yu, Evan Y.W., Wesselius, Anke, Mehrkanoon, Siamak, Brinkman, Maree, van den Brandt, Piet, White, Emily, Weiderpass, Elisabete, Le Calvez-Kelm, Florence, Gunter, Marc, Huybrechts, Inge, Liedberg, Fredrik, Skeie, Guri, Tjonneland, Anne, Riboli, Elio, Giles, Graham G., Milne, Roger L., and Zeegers, Maurice P.

Abstract

BACKGROUND: Higher intakes of whole grains and dietary fiber have been associated with lower risk of insulin resistance, hyperinsulinemia, and inflammation, which are known predisposing factors for cancer. OBJECTIVES: Because the evidence of association with bladder cancer (BC) is limited, we aimed to assess associations with BC risk for intakes of whole grains, refined grains, and dietary fiber. METHODS: We pooled individual data from 574,726 participants in 13 cohort studies, 3214 of whom developed incident BC. HRs, with corresponding 95% CIs, were estimated using Cox regression models stratified on cohort. Dose-response relations were examined using fractional polynomial regression models. RESULTS: We found that higher intake of total whole grain was associated with lower risk of BC (comparing highest with lowest intake tertile: HR: 0.87; 95% CI: 0.77, 0.98; HR per 1-SD increment: 0.95; 95% CI: 0.91, 0.99; P for trend: 0.023). No association was observed for intake of total refined grain. Intake of total dietary fiber was also inversely associated with BC risk (comparing highest with lowest intake tertile: HR: 0.86; 95% CI: 0.76, 0.98; HR per 1-SD increment: 0.91; 95% CI: 0.82, 0.98; P for trend: 0.021). In addition, dose-response analyses gave estimated HRs of 0.97 (95% CI: 0.95, 0.99) for intake of total whole grain and 0.96 (95% CI: 0.94, 0.98) for intake of total dietary fiber per 5-g daily increment. When considered jointly, highest intake of whole grains with the highest intake of dietary fiber showed 28% reduced risk (95% CI: 0.54, 0.93; P for trend: 0.031) of BC compared with the lowest intakes, suggesting potential synergism. CONCLUSIONS: Higher intakes of total whole grain and total dietary fiber are associated with reduced risk of BC individually and jointly. Further studies are needed to clarify the underlying mechanisms for these findings.

Published
2020

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