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7. Development of metastases in malignant melanoma is associated with an increase in the plasma L-dopa/L-tyrosine ratio

Author

Spy J, Le Bricon T, Bernard Bousquet, Michel Baccard, Kerneis Y, Jean-Pierre Garnier, Konstantin Stoitchkov, Sabine Letellier, and Revol M

Subjects
Adult, Male, Cancer Research, medicine.medical_specialty, Skin Neoplasms, Dermatology, Gastroenterology, Metastasis, Levodopa, Predictive Value of Tests, Reference Values, Internal medicine, Biomarkers, Tumor, medicine, Humans, Longitudinal Studies, Prospective Studies, Tyrosine, Stage (cooking), Prospective cohort study, Melanoma, Chromatography, High Pressure Liquid, Aged, Neoplasm Staging, Aged, 80 and over, Chemistry, Melanin precursors, Middle Aged, medicine.disease, Oncology, Female, Stage iv, Follow-Up Studies
Abstract

In this prospective study we evaluated a new biochemical approach in which the plasma ratio of the melanin precursors L-dopa and L-tyrosine serves as a marker of metastatic dissemination in malignant melanoma. Control values (11.20 x 10(-5) +/- 2.92 x 10(-5)) were determined. The L-dopa/L-tyrosine ratio was evaluated in the plasma of 90 patients with malignant melanoma (stage I/II, n = 33; stage III, n = 33; stage IV, n = 24) classified according to the tumour/node/metastasis (pTNM) classification. A total of 106 samples were studied. Serial measurements were performed in eight stage III-IV patients. The L-dopa/L-tyrosine ratio was significantly elevated in melanoma patients with clinical stage III (15.23 x 10(-5) +/- 3.34 x 10(-5)) compared with stage I (10.88 x 10(-5) +/- 2.52 x 10(-5)). Stage IV patients showed a significant increase in the plasma L-dopa/L-tyrosine ratio (45.73 x 10(-5) +/- 61.75 x 10(-5)) compared with the other groups. The ratio was higher for those with two rather than one metastatic site and markedly higher for those with widespread metastases. The development of metastases was associated with an increase in plasma L-dopa, a decrease in plasma L-tyrosine and a significant increase in the plasma L-dopa/L-tyrosine ratio. These data suggest that the plasma L-dopa/L-tyrosine ratio reflects the tumour burden and correlates with the progression of malignant melanoma.

Published
1999

38. Performances et stabilité du réactif QMS® lamotrigine sur CDx90® (ThermoFisherScientific).

Author

Magnolon, S., Raidelet, L., Munier, P., Barrial, K., Le Bricon, T., and Bronner, J.

Subjects
MICROSPHERES, LAMOTRIGINE, CHEMICAL reagents, TURBIDITY, BLOOD serum analysis, HIGH performance liquid chromatography
Abstract

Copyright of IBS, Immuno-analyse & Biologie Specialisee is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2012
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39. Interférence sur le dosage de la troponine Ic sur Beckman Coulter DxC600i/880i® : à propos d’un cas d’anticorps hétérophiles.

Author

Barrial, K., Courtier, F., Le Bricon, T., Chazalet, E., Blanc, Q., Sartre, J., and Bronner, J.

Subjects
IMMUNOASSAY, BLOOD plasma, MYOCARDIAL infarction, ISCHEMIA, MUSCLE contraction, PROTEINS, IMMUNOGLOBULINS, MYOGLOBIN, HEART diseases, CRITICAL care medicine, HOSPITALS
Abstract

Copyright of IBS, Immuno-analyse & Biologie Specialisee is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2010
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40. Évaluation du CDx90® (Microgenics Thermo Fisher Scientific) pour le dosage urinaire des drogues.

Author

Barrial, K., Le Bricon, T., Courtier, F., Tourvieille, M.-H., Hilaire, S., Carry, C., André, A., Sartre, J., and Bronner, J.

Subjects
DRUGS of abuse, URINALYSIS, CLINICAL chemistry, METHADONE abuse, BENZODIAZEPINES, COCAINE, NARCOTICS, DRUG toxicity, EQUIPMENT & supplies
Abstract

Copyright of IBS, Immuno-analyse & Biologie Specialisee is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2010
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41. New electrophoresis techniques applied to protein and DNA analysis.

Author

Trivin, F. and Le Bricon, T.

Subjects
DNA, ELECTROPHORESIS, SERODIAGNOSIS
Abstract

Copyright of IBS, Immuno-analyse & Biologie Specialisee is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2003
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42. Electrophoretic separation of phosphatase alkaline isoenzymes with the Hydragel 15 Iso-PAL® Kit.

Author

Gilles, C., Moley, M., Benlakehal, M., Bousquet, B., and Le Bricon, T.

Subjects
ELECTROPHORESIS, PHOSPHATASES, BONE diseases
Abstract

Copyright of IBS, Immuno-analyse & Biologie Specialisee is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2002
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46. Supplemental nutrition with ornithine alpha-ketoglutarate in rats with cancer-associated cachexia: surgical treatment of the tumor improves efficacy of nutritional support

Author

Le Bricon T, Cynober L, Catherine Field, and Ve, Baracos

Subjects
Male, Ornithine, Cachexia, Nitrogen, Glutamine, Body Weight, Glycine, Combined Modality Therapy, Neoplasm Proteins, Rats, Rats, Sprague-Dawley, Eating, Liver Neoplasms, Experimental, Food, Fortified, Intestine, Small, Tumor Cells, Cultured, Animals, Amino Acids, Muscle, Skeletal, Oxidation-Reduction
Abstract

We investigated the use of ornithine alpha-ketoglutarate in treatment of rats bearing Morris hepatoma 7777. Rats received diets containing either ornithine alpha-ketoglutarate, which has been used in other catabolic states (i.e. injury, sepsis), or an isonitrogenous, isocaloric diet containing glycine. Untreated tumors grew to a mass of 11 g/100 g body weight over the 3-wk period after implantation and induced progressive anorexia, negative nitrogen balance, and body and tissue wasting. Compared with glycine, ornithine alpha-ketoglutarate had no effect on tumor growth, but also did not alter the catabolic effects of the tumor on its host. We hypothesized that capture of amino acids by the tumor limited the efficacy of supplemental nutrition here and in published reports in which tumor burden comprised 4-30% of body weight. This is supported by our observation that a 3-wk of implantation the rate of protein deposition plus amino acid oxidation by the tumor was equivalent to approximately 70% of the host's daily protein intake. To parallel the clinical situation in which tumor burden is small at diagnosis and initiation of treatment, the same diets were tested in rats treated by excision of the tumor at a limited stage of the disease. Rats received 3 d preoperative nutrition with ornithine alpha-ketoglutarate or glycine, and continued on the same diets for 3 or 6 d postoperatively. Compared with glycine-fed rats, ornithine alpha-ketoglutarate-fed rats showed a more positive nitrogen balance, higher concentrations of glutamine and branched-chain amino acids in muscle, and accelerated protein deposition in small intestine (P0.05). Our results explain the lack of success of nutritional support in untreated cancer and underline the need for clinically relevant animal models for further studies.

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