30 results on '"León JP"'
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2. The degenerative cervical spine
- Author
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Llopis E, Belloch E, León JP, Higueras V, and Piquer J
- Subjects
Imaging, Three-Dimensional ,Cervical Vertebrae ,Humans ,Spinal Diseases ,Tomography, X-Ray Computed ,Magnetic Resonance Imaging - Abstract
Imaging techniques provide excellent anatomical images of the cervical spine. The choice to use one technique or another will depend on the clinical scenario and on the treatment options. Plain-film X-rays continue to be fundamental, because they make it possible to evaluate the alignment and bone changes; they are also useful for follow-up after treatment. The better contrast resolution provided by magnetic resonance imaging makes it possible to evaluate the soft tissues, including the intervertebral discs, ligaments, bone marrow, and spinal cord. The role of computed tomography in the study of degenerative disease has changed in recent years owing to its great spatial resolution and its capacity to depict osseous components. In this article, we will review the anatomy and biomechanical characteristics of the cervical spine, and then we provide a more detailed discussion of the degenerative diseases that can affect the cervical spine and their clinical management. (C) 2015 SERAM. Published by Elsevier Espana, S.L.U. All rights reserved.
- Published
- 2015
3. Valor diagnóstico del cultivo cuantitativo del aspirado endotraqueal en la neumonía adquirida durante la ventilación mecánica. Estudio multicéntrico
- Author
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Valencia Arango, M, primary, Torres Martí, A, additional, Insausti Ordeñana, J, additional, Álvarez Lerma, F, additional, Carrasco Joaquinet, N, additional, Herranz Casado, M, additional, and Tirapu León, JP, additional
- Published
- 2003
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4. ESICM LIVES 2016: part three : Milan, Italy. 1-5 October 2016
- Author
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Velasquez, T., Mackey, G., Lusk, J., Kyle, Ug, Fontenot, T., Marshall, P., Shekerdemian, Ls, Coss-Bu, Ja, Nishigaki, A., Yatabe, T., Tamura, T., Yamashita, K., Yokoyama, M., Ruiz-Rodriguez, Jc, Encina, B., Belmonte, R., Troncoso, I., Tormos, P., Riveiro, M., Baena, J., Sanchez, A., Bañeras, J., Cordón, J., Duran, N., Ruiz, A., Caballero, J., Nuvials, X., Riera, J., Serra, J., Rutten, Am, Ieperen, Sn, Kinderen, Ep, Logten, T., Kovacikova, L., Skrak, P., Zahorec, M., Akcan-Arikan, A., Silva, Jc, Goldsworthy, M., Wood, D., Harrison, D., Parslow, R., Davis, P., Pappachan, J., Goodwin, S., Ramnarayan, P., Chernyshuk, S., Yemets, H., Zhovnir, V., Pulitano, Sm, Rosa, S., Mancino, A., Villa, G., Tosi, F., Franchi, P., Conti, G., Patel, B., Khine, H., Shah, A., Sung, D., Singer, L., Haghbin, S., Inaloo, S., Serati, Z., Idei, M., Nomura, T., Yamamoto, N., Sakai, Y., Yoshida, T., Matsuda, Y., Yamaguchi, Y., Takaki, S., Yamaguchi, O., Goto, T., Longani, N., Medar, S., Abdel-Aal, Ir, El Adawy, As, Mohammed, Hm, Mohamed, An, Parry, Sm, Knight, Ld, Denehy, L., Morton, N., Baldwin, Ce, Sani, D., Kayambu, G., Da Silva, Vz, Phongpagdi, P., Puthucheary, Za, Granger, Cl, Rydingsward, Je, Horkan, Cm, Christopher, Kb, Mcwilliams, D., Jones, C., Reeves, E., Atkins, G., Snelson, C., Aitken, Lm, Rattray, J., Kenardy, J., Hull, Am, Ullman, A., Le Brocque, R., Mitchell, M., Davis, C., Macfarlane, B., Azevedo, Jc, Rocha, Ll, Freitas, Ff, Cavalheiro, Am, Lucinio, Nm, Lobato, Ms, Ebeling, G., Kraegpoeth, A., Laerkner, E., Brito-Ashurst, I., White, C., Gregory, S., Forni, Lg, Flowers, E., Curtis, A., Wood, Ca, Siu, K., Venkatesan, K., Muhammad, Jb, Ng, L., Seet, E., Baptista, N., Escoval, A., Tomas, E., Agrawal, R., Mathew, R., Varma, A., Dima, E., Charitidou, E., Perivolioti, E., Pratikaki, M., Vrettou, C., Giannopoulos, A., Zakynthinos, S., Routsi, C., Atchade, E., Houzé, S., Jean-Baptiste, S., Thabut, G., Genève, C., Tanaka, S., Lortat-Jacob, B., Augustin, P., Desmard, M., Montravers, P., 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Rotzel, Hb, Lázaro, As, Prada, Da, Gimillo, MR, Barinas, Od, Cortes, Ml, Franco, Jf, Roca, Jm, Carratalá, A., Gonçalves, B., Turon, R., Mendes, A., Miranda, F., Mata, Pj, Cavalcanti, D., Melo, N., Lacerda, P., Kurtz, P., Righy, C., Rosario, Le, Lesmes, Sp, Romero, Jc, Herrera, An, Pertuz, Ed, Sánchez, Mj, Sanz, Er, Hualde, Jb, Hernández, Aa, Irazabal, Jm, Spatenkova, V., Bradac, O., Suchomel, P., Urli, T., Lazzeri, Eh, Aspide, R., Zanello, M., Perez-Borrero, L., Garcia-Alvarez, Jm, Arias-Verdu, Md, Aguilar-Alonso, E., Rivera-Fernandez, R., Mora-Ordoñez, J., La Fuente-Martos, C., Castillo-Lorente, E., Guerrero-Lopez, F., Ramírez, Jr, León, Jp, Navarro-Guillamón, L., Cordovilla-Guardia, S., Iglesias-Santiago, A., Guerrero-López, F., Fernández-Mondéjar, E., Vidal, A., Perez, M., Juez, A., Arias, N., Colino, L., Perez, Jl, Pérez, H., Calpe, P., Alcala, Ma, Robaglia, D., Perez, C., Lan, Sk, Cunha, Mm, Moreira, T., Santos, F., Lafuente, E., Fernandes, Mj, Silva, Jg, Echeverría, Jg, 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F., Brazzi, L., Fritz, C., Kimmoun, A., Vanhuyse, F., Trifan, B., Orlowski, S., Albuisson, E., Tran, N., Levy, B., Chhor, V., Joachim, J., Chatelon, J., Fave, G., Mantz, J., Diaz, Dd, Villanova, M., Aguirregabyria, M., Andrade, G., López, L., John, G., Cowan, R., Hart, R., Lake, K., Litchfield, K., Song, Jw, Lee, Yj, Cho, Yj, Choi, S., Vermeir, P., Vandijck, D., Mariman, A., Verhaeghe, R., Deveugele, M., Vogelaers, D., Chok, L., Bachli, Eb, Bettex, D., Cottini, Sr, Keller, E., Maggiorini, M., Schuepbach, R., Stiphout, C., Grevelink, M., Vaneker, I., Ruijter, A., Buise, M., Tena, Sa, Barrachina, Lg, Portillo, Jh, Aznar, Gp, Campos, Lm, Sellés, Md, Tomás, Ma, Muncharaz, Ab, Skinner, L., Monsalvo, S., Olavarria, E., Stümpfle, R., Na, Sj, Park, J., Chung, Cr, Suh, Gy, Yang, Jh, Witter, T., Brousseau, C., Butler, Mb, Erdogan, M., Dougall, Pc, Green, Rs, Abbott, Te, Torrance, Hd, Cron, N., Vaid, N., Emmanuel, J., Siddiqui, Ss, Prabu, N., Chaudhari, Hk, Patil, Vp, Divatia, Jv, Solanki, S., Kulkarni, Ap, Gutierrez, La, Brasseur, A., Hempel, D., Stauffert, N., Recker, F., Schröder, T., Reusch, S., Schleifer, J., Breitkreutz, R., Sjövall, F., Møller, Mh, Moraes, Rb, Borges, Fk, Guillen, Ja, Zabaletta, Wj, Pics- Hcpa, Programa Intrahospitalar Combate À Sepse Do Hospital Clínicas Porto Alegre, Ruiz-Ramos, J., Marqués-Miñana, MR, Sosa, M., Concha, P., Menendez, R., Ramírez, Cs, Santana, Mc, Balcázar, Lc, Escalada, Sh, Viera, Ma, Vázquez, Cf, Díaz, Jj, Campelo, Fa, Monroy, Ns, Santana, Ps, Santana, Sr, Gutiérrez-Pizarraya, A., Garnacho-Montero, J., Martin, C., Mainardi, Jl, Cholley, B., Hubbard, A., Frontera, Pr, Vega, Lm, Miguelena, Pr, Usón, Mc, López, Ar, Clemente, Ea, Ibañes, Pg, Aguilar, Al, Palomar, M., Olaechea, P., Uriona, S., Vallverdu, M., Catalan, M., Aragon, C., Lerma, Fa, Envin-Helics, Study Group, Bassi, Gl, Xiol, Ea, Senussi, T., Idone, Fa, Motos, A., Travierso, C., Fernández-Barat, L., Amaro, R., Hua, Y., Ranzani, Ot, Bobi, Q., Rigol, M., Torres, A., Fernández, 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5. Q-RPL: Q-Learning-Based Routing Protocol for Advanced Metering Infrastructure in Smart Grids.
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Duenas Santos CL, Mezher AM, Astudillo León JP, Cardenas Barrera J, Castillo Guerra E, and Meng J
- Abstract
Efficient and reliable data routing is critical in Advanced Metering Infrastructure (AMI) within Smart Grids, dictating the overall network performance and resilience. This paper introduces Q-RPL, a novel Q-learning-based Routing Protocol designed to enhance routing decisions in AMI deployments based on wireless mesh technologies. Q-RPL leverages the principles of Reinforcement Learning (RL) to dynamically select optimal next-hop forwarding candidates, adapting to changing network conditions. The protocol operates on top of the standard IPv6 Routing Protocol for Low-Power and Lossy Networks (RPL), integrating it with intelligent decision-making capabilities. Through extensive simulations carried out in real map scenarios, Q-RPL demonstrates a significant improvement in key performance metrics such as packet delivery ratio, end-to-end delay, and compliant factor compared to the standard RPL implementation and other benchmark algorithms found in the literature. The adaptability and robustness of Q-RPL mark a significant advancement in the evolution of routing protocols for Smart Grid AMI, promising enhanced efficiency and reliability for future intelligent energy systems. The findings of this study also underscore the potential of Reinforcement Learning to improve networking protocols.
- Published
- 2024
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6. Analysis of performance, emissions, and lubrication in a spark-ignition engine fueled with hydrogen gas mixtures.
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García CP, Orjuela Abril S, and León JP
- Abstract
Hydrogen is one of the main alternative fuels with the greatest potential to replace fossil fuels due to its renewable and environmentally friendly nature. Due to this, the present investigation aims to evaluate the combustion characteristics, performance parameters, emissions, and variations in the characteristics of the lubricating oil. The investigation was conducted in a spark-ignition engine fueled by gasoline and hydrogen gas. Four engine load conditions (25%, 50%, 75%, and 100%) and three hydrogen gas mass concentration conditions (3%, 6%, and 9%) were defined for the study. The investigation results allowed to demonstrate that the injection of hydrogen gas in the gasoline engine causes an increase of 3.2% and 4.0% in the maximum values of combustion pressure and heat release rates. Additionally, hydrogen causes a 2.9% increase in engine BTE. Hydrogen's more efficient combustion process allowed for reducing CO, HC, and smoke opacity emissions. However, hydrogen gas causes an additional increase of 14.5% and 30.4% in reducing the kinematic viscosity and the total base number of the lubricating oil. In addition, there was evidence of an increase in the concentration of wear debris, such as Fe and Cu, which implies higher rates of wear in the engine's internal components., Competing Interests: The authors declare no conflict of interest., (© 2022 The Author(s).)
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- 2022
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7. Portomesenteric venous thrombosis post gastric sleeve.
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Palomares JP, Barajas IG, León VJ, Estrada IE, Guzmán Barba JA, and Orozco Álvarez-Malo JO
- Abstract
The gastric sleeve is the most performed bariatric surgery, and several studies have shown a good safety profile. Among its main postoperative complications are bleeding, leak, stenosis, reflux and to a lesser extent, portomesenteric venous thrombosis (1%). More than 80% of this entity occur after discharge. Diagnosis is difficult because it does not have characteristic symptoms or laboratory abnormalities. A 30-year-old male with a body mass index of 40.2 kg/m
2 , submitted to gastric sleeve, developing tachycardia, abdominal pain and oral intolerance on the eighth postoperative day. Contrast-enhanced abdominopelvic tomography revealed thrombosis of the portal, mesenteric and splenic veins. Portomesenteric venous thrombosis managed with resection, laparoscopic entero-entero anastomosis and anticoagulation. Although the risk of presenting portomesenteric venous thrombosis is relatively low, its complications are serious and life-threatening, in addition to an increased prevalence in bariatric surgeries., (Published by Oxford University Press and JSCR Publishing Ltd. © The Author(s) 2022.)- Published
- 2022
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8. Are we ready to track climate-driven shifts in marine species across international boundaries? - A global survey of scientific bottom trawl data.
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A Maureaud A, Frelat R, Pécuchet L, Shackell N, Mérigot B, Pinsky ML, Amador K, Anderson SC, Arkhipkin A, Auber A, Barri I, Bell RJ, Belmaker J, Beukhof E, Camara ML, Guevara-Carrasco R, Choi J, Christensen HT, Conner J, Cubillos LA, Diadhiou HD, Edelist D, Emblemsvåg M, Ernst B, Fairweather TP, Fock HO, Friedland KD, Garcia CB, Gascuel D, Gislason H, Goren M, Guitton J, Jouffre D, Hattab T, Hidalgo M, Kathena JN, Knuckey I, Kidé SO, Koen-Alonso M, Koopman M, Kulik V, León JP, Levitt-Barmats Y, Lindegren M, Llope M, Massiot-Granier F, Masski H, McLean M, Meissa B, Mérillet L, Mihneva V, Nunoo FKE, O'Driscoll R, O'Leary CA, Petrova E, Ramos JE, Refes W, Román-Marcote E, Siegstad H, Sobrino I, Sólmundsson J, Sonin O, Spies I, Steingrund P, Stephenson F, Stern N, Tserkova F, Tserpes G, Tzanatos E, van Rijn I, van Zwieten PAM, Vasilakopoulos P, Yepsen DV, Ziegler P, and T Thorson J
- Subjects
- Animals, Climate Change, Fishes, Surveys and Questionnaires, Ecosystem, Fisheries
- Abstract
Marine biota are redistributing at a rapid pace in response to climate change and shifting seascapes. While changes in fish populations and community structure threaten the sustainability of fisheries, our capacity to adapt by tracking and projecting marine species remains a challenge due to data discontinuities in biological observations, lack of data availability, and mismatch between data and real species distributions. To assess the extent of this challenge, we review the global status and accessibility of ongoing scientific bottom trawl surveys. In total, we gathered metadata for 283,925 samples from 95 surveys conducted regularly from 2001 to 2019. We identified that 59% of the metadata collected are not publicly available, highlighting that the availability of data is the most important challenge to assess species redistributions under global climate change. Given that the primary purpose of surveys is to provide independent data to inform stock assessment of commercially important populations, we further highlight that single surveys do not cover the full range of the main commercial demersal fish species. An average of 18 surveys is needed to cover at least 50% of species ranges, demonstrating the importance of combining multiple surveys to evaluate species range shifts. We assess the potential for combining surveys to track transboundary species redistributions and show that differences in sampling schemes and inconsistency in sampling can be overcome with spatio-temporal modeling to follow species density redistributions. In light of our global assessment, we establish a framework for improving the management and conservation of transboundary and migrating marine demersal species. We provide directions to improve data availability and encourage countries to share survey data, to assess species vulnerabilities, and to support management adaptation in a time of climate-driven ocean changes., (© 2020 The Authors. Global Change Biology published by John Wiley & Sons Ltd.)
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- 2021
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9. A Joint Multi-Path and Multi-Channel Protocol for Traffic Routing in Smart Grid Neighborhood Area Networks.
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Astudillo León JP and de la Cruz Llopis LJ
- Abstract
In order to improve the management mechanisms of the electric energy transport infrastructures, the smart grid networks have associated data networks that are responsible for transporting the necessary information between the different elements of the electricity network and the control center. Besides, they make possible a more efficient use of this type of energy. Part of these data networks is comprised of the Neighborhood Area Networks (NANs), which are responsible for interconnecting the different smart meters and other possible devices present at the consumers' premises with the control center. Among the proposed network technologies for NANs, wireless technologies are becoming more relevant due to their flexibility and increasing available bandwidth. In this paper, some general modifications are proposed for the routing protocol of the wireless multi-hop mesh networks standardized by the IEEE. In particular, the possibility of using multiple paths and transmission channels at the same time, depending on the quality of service needs of the different network traffic, is added. The proposed modifications have been implemented in the ns-3 simulator and evaluated in situations of high traffic load. Simulation results show improvements in the network performance in terms of packet delivery ratio, throughput and network transit time.
- Published
- 2018
- Full Text
- View/download PDF
10. Robotic kidney transplantation: one year after the beginning.
- Author
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Breda A, Territo A, Gausa L, Rodríguez-Faba O, Caffaratti J, de León JP, Guirado L, Facundo C, Guazzieri M, Guttilla A, and Villavicencio H
- Subjects
- Adult, Female, Humans, Kidney Failure, Chronic surgery, Kidney Transplantation, Male, Middle Aged, Patient Selection, Pilot Projects, Prospective Studies, Recovery of Function, Robotic Surgical Procedures, Spain, Treatment Outcome, Postoperative Complications diagnosis, Postoperative Complications etiology
- Abstract
Introduction: Kidney transplantation (KT) is the preferred treatment for patients with end-stage renal disease (ESRD). To reduce the morbidity of the open surgery, a robotic-assisted approach has been recently introduced. Our aim is to evaluate surgical and functional results on 17 cases of robotic-assisted kidney transplantation (RAKT) performed at the same institution., Materials and Methods: From July 2015 to June 2016, we performed 17 cases of RAKT from living donors in pre-emptive patients, who underwent laparoscopic nephrectomy. A prospective pilot study was made at Fundació Puigvert (Barcelona), evaluating functional and surgical outcomes. In this series, we considered the functional results, surgical outcomes and complications rates., Results: Seventeen patients successfully underwent RAKT, in particular surgical console time was 181 min (150-200) with vascular suture time 42 min (32-48), and estimated blood loss <70 ml. Overall ischemia time was 98.9 min (84-140). No patient was converted to open transplantation. No major surgical intra-operative complications were observed. The mean post-operative serum creatinine level 160 μmol/L (81-479). We reported a case of delayed graft function (DGF), one case of graft arterial thrombosis and one case of intraperitoneal hematoma. No anastomosis revision and wounds infections occurred., Conclusion: RAKT with regional hypothermia appears to be a safe surgical procedure in a properly selected group of patients. The potential advantages of RAKT are related to the quality of the vascular anastomosis, the possible lower complication rate and the shorter recovery of the recipients.
- Published
- 2017
- Full Text
- View/download PDF
11. The degenerative cervical spine.
- Author
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Llopis E, Belloch E, León JP, Higueras V, and Piquer J
- Subjects
- Cervical Vertebrae anatomy & histology, Humans, Imaging, Three-Dimensional, Magnetic Resonance Imaging, Tomography, X-Ray Computed, Cervical Vertebrae diagnostic imaging, Spinal Diseases diagnostic imaging
- Abstract
Imaging techniques provide excellent anatomical images of the cervical spine. The choice to use one technique or another will depend on the clinical scenario and on the treatment options. Plain-film X-rays continue to be fundamental, because they make it possible to evaluate the alignment and bone changes; they are also useful for follow-up after treatment. The better contrast resolution provided by magnetic resonance imaging makes it possible to evaluate the soft tissues, including the intervertebral discs, ligaments, bone marrow, and spinal cord. The role of computed tomography in the study of degenerative disease has changed in recent years owing to its great spatial resolution and its capacity to depict osseous components. In this article, we will review the anatomy and biomechanical characteristics of the cervical spine, and then we provide a more detailed discussion of the degenerative diseases that can affect the cervical spine and their clinical management., (Copyright © 2015 SERAM. Published by Elsevier España, S.L.U. All rights reserved.)
- Published
- 2016
- Full Text
- View/download PDF
12. Robotic-assisted kidney transplantation: our first case.
- Author
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Breda A, Gausa L, Territo A, López-Martínez JM, Rodríguez-Faba O, Caffaratti J, de León JP, Guirado L, and Villavicencio H
- Subjects
- Adult, Female, Follow-Up Studies, Humans, Laparoscopy methods, Operative Time, Kidney Failure, Chronic surgery, Kidney Transplantation methods, Living Donors, Nephrectomy methods, Robotics methods, Tissue and Organ Procurement
- Abstract
Purpose: Kidney transplantation is the preferred treatment for patients with end-stage renal disease. In order to reduce the morbidity of the open surgery, a robotic-assisted approach has been recently introduced. According to the published literature, the robotic surgery allows the performance of kidney transplantation under optimal operative conditions while maintaining the safety and the functional results of the open approach., Methods: We present the case of a mother donating to her daughter affected by end-stage renal disease (ESRD) due to Alport disease (creatinine: 353 umol/l; GFR: 13 ml/min per 1.73 m(2))., Results: A robotic-assisted kidney transplant (RAKT) was successfully performed. Surgical time was 120 min with 53 min for vascular suture. The estimated blood loss was <50 cc. The kidney started to produce urine intra-operatively with a rate of 250 cc/h, which remained constant over the next hours. During the first postoperative day, the patient was ambulating and started oral intake. Pain was minimal, and no analgesia was required after 48 h. Serum creatinine improved progressively to 89 umol/l on postoperative day 3. No surgical complications were recorded, and the patient was sent home on postoperative day 5., Conclusion: We present the first Spanish transperitoneal pure RAKT from a living-related donor. We believe this is the second pure robotic-assisted kidney transplantation case performed in Europe. We believe that the potential advantages of RAKT are related to the quality of the vascular anastomosis, the possible lower complication rate and the shorter recovery of the recipients.
- Published
- 2016
- Full Text
- View/download PDF
13. SEMICYUC 2012. Recommendations for intensive care management of acute pancreatitis.
- Author
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Maraví Poma E, Zubia Olascoaga F, Petrov MS, Navarro Soto S, Laplaza Santos C, Morales Alava F, Darnell Martin A, Gorraiz López B, Bolado Concejo F, Casi Villarroya M, Aizcorbe Garralda M, Albeniz Arbizu E, Sánchez-Izquierdo Riera JA, Tirapu León JP, Bordejé Laguna L, López Camps V, Marcos Neira P, Regidor Sanz E, and Jiménez Mendioroz F
- Subjects
- Acute Disease, Hemodiafiltration, Humans, Pancreatitis classification, Pancreatitis surgery, Critical Care standards, Pancreatitis diagnosis, Pancreatitis therapy
- Abstract
Objective: Significant changes in the management of acute pancreatitis have taken place since the 2004 Pamplona Consensus Conference. The objective of this conference has been the revision and updating of the Conference recommendations, in order to unify the integral management of potentially severe acute pancreatitis in an ICU., Participants: Spanish and international intensive medicine physicians, radiologists, surgeons, gastroenterologists, emergency care physicians and other physicians involved in the treatment of acute pancreatitis. LEVELS OF EVIDENCE AND GRADES OF RECOMMENDATION: The GRADE method has been used for drawing them up. DRAWING UP THE RECOMMENDATIONS: The selection of the committee members was performed by means of a public announcement. The bibliography has been revised from 2004 to the present day and 16 blocks of questions on acute pancreatitis in a ICU have been drawn up. Firstly, all the questions according to groups have been drawn up in order to prepare one document. This document has been debated and agreed upon by computer at the SEMICYUC Congress and lastly at the Consensus Conference which was held with the sole objective of drawing up these recommendations., Conclusions: Eighty two recommendations for acute pancreatitis management in an ICU have been presented. Of these 84 recommendations, we would emphasize the new determinants-based classification of acute pancreatitis severity, new surgical techniques and nutritional recommendations. Note. This summary only lists the 84 recommendations of the 16 questions blocks except blocks greater relevance and impact of its novelty or because they modify the current management., (Copyright © 2013 Elsevier España, S.L. and SEMICYUC. All rights reserved.)
- Published
- 2013
- Full Text
- View/download PDF
14. Hemangioma of the prostatic urethra: holmium laser treatment.
- Author
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de León JP, Arce J, Gausa L, and Villavicencio H
- Subjects
- Adult, Endoscopy methods, Humans, Male, Treatment Outcome, Urethral Stricture therapy, Hemangioma therapy, Laser Therapy methods, Lasers, Solid-State, Prostate pathology, Urethra pathology, Urology methods
- Abstract
Urethral hemangiomas are benign vascular tumors that are found in perimontanal prostatic localization and less frequently in the urethra. Although different urethral procedures have been postulated for its treatment, the best results are achieved using lasers. A patient who underwent endoscopic holmium laser treatment for such hemangiomas is presented. Total disappearance of the lesions without any complications was achieved., ((c) 2008 S. Karger AG, Basel.)
- Published
- 2008
- Full Text
- View/download PDF
15. Erectile function, sexual drive, and ejaculatory function alter reconstructive surgery for anterior urethral stricture disease.
- Author
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de León JP
- Subjects
- Erectile Dysfunction physiopathology, Follow-Up Studies, Humans, Male, Retrospective Studies, Urologic Surgical Procedures, Male adverse effects, Ejaculation physiology, Erectile Dysfunction etiology, Libido physiology, Urethral Stricture surgery, Urologic Surgical Procedures, Male standards
- Published
- 2007
- Full Text
- View/download PDF
16. Tamoxifen and endometrial cancer. Is screening necessary? A review of the literature.
- Author
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Machado F, Rodríguez JR, León JP, Rodríguez JR, Parrilla JJ, and Abad L
- Subjects
- Breast Neoplasms drug therapy, Endometrial Neoplasms chemically induced, Endometrium drug effects, Female, Humans, Antineoplastic Agents, Hormonal adverse effects, Endometrial Neoplasms diagnosis, Mass Screening methods, Selective Estrogen Receptor Modulators adverse effects, Tamoxifen adverse effects
- Abstract
Tamoxifen is a selective oestrogen receptor modulator (SERM) with anti-oestrogenic activity in the breast and oestrogenic effects in various tissues such as the endometrium, bone and cardiovascular territory. As adjuvant hormone therapy, it has a clear beneficial effect in patients with breast cancer, reducing relapses, contralateral breast cancer and mortality. Its most important secondary effect is a greater rate of occurrence of endometrial cancer. Although the risk/benefit ratio is clearly positive, the follow-up on these patients is still an issue. In women with metrorrhagia, it is clear that an endometrial sample must be obtained for histological examination and the best procedure today is hysteroscopic-directed biopsy. Nevertheless, the need to screen asymptomatic patients is not universally accepted. The vaginal ultrasound scan gives a great number of false positives. This entails more aggressive and more expensive procedures such as hysteroscopic-directed biopsy, meaning greater expense and more complications. As a result, the cost/benefit ratio is not very favourable. The rate of occurrence of endometrial cancer in 1026 tamoxifen-treated patients with breast cancer in our hospital between 1999 and 2001 was 1.25%. Two cases were diagnosed in asymptomatic patients. In this article, we analyse the literature on the need to screen patients on tamoxifen and about the most appropriate diagnostic protocol.
- Published
- 2005
17. Coordinated genetic regulation of growth and lignin revealed by quantitative trait locus analysis of cDNA microarray data in an interspecific backcross of eucalyptus.
- Author
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Kirst M, Myburg AA, De León JP, Kirst ME, Scott J, and Sederoff R
- Subjects
- Base Sequence, Chromosome Mapping, DNA Primers, Eucalyptus growth & development, Eucalyptus metabolism, Gene Expression Profiling, Gene Expression Regulation, Plant, Molecular Sequence Data, Oligonucleotide Array Sequence Analysis, Crosses, Genetic, Eucalyptus genetics, Lignin metabolism, Quantitative Trait Loci
- Abstract
Phenotypic, genotypic, and transcript level (microarray) data from an interspecific backcross population of Eucalyptus grandis and Eucalyptus globulus were integrated to dissect the genetic and metabolic network underlying growth variation. Transcript abundance, measured for 2,608 genes in the differentiating xylem of a 91 (E. grandis x E. globulus) x E. grandis backcross progeny was correlated with diameter variation, revealing coordinated down-regulation of genes encoding enzymes of the lignin biosynthesis and associated methylation pathways in fast growing individuals. Lignin analysis of wood samples confirmed the content and quality predicted by the transcript levels measured on the microarrays. Quantitative trait locus (QTL) analysis of transcript levels of lignin-related genes showed that their mRNA abundance is regulated by two genetic loci, demonstrating coordinated genetic control over lignin biosynthesis. These two loci colocalize with QTLs for growth, suggesting that the same genomic regions are regulating growth, and lignin content and composition in the progeny. Genetic mapping of the lignin genes revealed that most of the key biosynthetic genes do not colocalize with growth and transcript level QTLs, with the exception of the locus encoding the enzyme S-adenosylmethionine synthase. This study illustrates the power of integrating quantitative analysis of gene expression data and genetic map information to discover genetic and metabolic networks regulating complex biological traits. (Sequence data for this article have been deposited with the EMBL/GenBank data libraries under accession numbers CB 967505 to CB 968059; CD 667988 to CD 670002; CD 670004; CD 670097; CD 670101 to CD 670112; and CD 670114 to CD 670137.)
- Published
- 2004
- Full Text
- View/download PDF
18. [Diagnostic value of quantitative cultures of endotracheal aspirate in ventilator-associated pneumonia: a multicenter study].
- Author
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Valencia Arango M, Torres Martí A, Insausti Ordeñana J, Alvarez Lerma F, Carrasco Joaquinet N, Herranz Casado M, and Tirapu León JP
- Subjects
- Bronchoscopy, Case-Control Studies, Cross Infection microbiology, Cross Infection therapy, Humans, Intubation, Intratracheal adverse effects, Pneumonia, Bacterial microbiology, Pneumonia, Bacterial therapy, Predictive Value of Tests, Prospective Studies, ROC Curve, Respiration, Artificial adverse effects, Sensitivity and Specificity, Cross Infection diagnosis, Microbiological Techniques methods, Pneumonia, Bacterial diagnosis, Trachea microbiology
- Abstract
Objective: To study the validity of quantitative cultures of tracheal aspirate (TA) in comparison with the plugged telescoping catheter (PTC) for the diagnosis of mechanical ventilator-associated pneumonia., Method: Prospective multicenter study enrolling patients undergoing mechanical ventilation for longer than 72 hours. TA samples were collected from patients with suspected ventilator-associated pneumonia, followed by PTC sampling. Quantitative cultures were performed on all samples. Patients were classified according to the presence or not of pneumonia, based on clinical and radiologic criteria, clinical course and autopsy findings. The cutoff points were > or = 103 colony-forming units (cfu)/mL for PTC cultures; the TA cutoffs analyzed were > or = 105 and > or = 106 cfu/mL., Results: Of the 120 patients studied, 84 had diagnoses of pneumonia and 36 did not (controls). The sensitivity values for TA > or = 106, TA > or = 105, and PTC, respectively, were 54% (95% confidence interval [CI], 42%-64%), 71% (95% CI, 60%-81%), and 68% (95% CI, 57%-78%). The specificity values were 75% (95% CI, 58%-88%), 58% (95% CI, 41%-74%), and 75% (95% CI, 58%-88%), respectively. Staphylococcus aureus was the microorganism most frequently isolated in both TA and PTC samples, followed in frequency by Pseudomomonas aeruginosa in TA samples and Haemophilus influenzae in PTC samples. No significant differences were found between the sensitivity of TA > or = 105 and that of PTC, nor between the specificities of TA > or = 106 and PTC., Conclusions: No differences in the specificities of PTC and TA were found when a TA cutoff of > or = 106 cfu/ml was used. Moreover, at a cutoff of > or = 105 the sensitivity of TA was not statistically different from that of PTC. Quantitative cultures of TA can be considered acceptable for the diagnosis of ventilator-associated pneumonia.
- Published
- 2003
- Full Text
- View/download PDF
19. [Surgery of congenital cardiopathies without previous catheterization. Preoperative evaluation and surgical indication using bidimensional echocardiography and Doppler].
- Author
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Gómez R, Maître MJ, León JP, Rico F, Villagrá F, Sánchez PA, Checa SL, Núñez P, and Brito JM
- Subjects
- Adolescent, Catheterization, Child, Child, Preschool, Echocardiography, Heart Defects, Congenital diagnosis, Humans, Infant, Infant, Newborn, Preoperative Care, Echocardiography, Doppler, Heart Defects, Congenital surgery
- Abstract
With the non-invasive devices available nowadays, many congenital heart diseases may be diagnosed with a definition comparable and even perhaps superior to catheterization and angiography. According to this issue, from January 1983 to December 1987, 239 children underwent operations for palliation or correction of different cardiopathies based on an echo-Doppler assessment without prior catheterization. Preoperative echo-Doppler diagnoses had an adequate correlation with the surgical findings in 234 cases (97.9 percent), so there was no correlation in 5 cases. In general, we consider that echo-Doppler provides a complete and definitive diagnosis in most cases, thus eliminating the need for further invasive procedures, although we still have to rely on catheterization to obtain the necessary information or reassurance in some cases. Progressive increase of reliance in echo-Doppler techniques by the surgeon and self confidence of the cardiologist in his accurate state of the art will considerably increase the performance of cardiac operations without prior catheterization in the future. At present, this is our current policy, as day after day, we are increasing the diagnoses in which we consider unnecessary the catheterization to indicate surgery.
- Published
- 1989
20. Ventricular septal defect in infancy. Surgical criteria and experience.
- Author
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Gómez R, Sánchez PA, Martínez R, León JP, Arteaga M, Villagrá F, Verduras MJ, Checa SL, and Brito JM
- Subjects
- Aortic Coarctation complications, Child, Preschool, Ductus Arteriosus, Patent complications, Heart Septal Defects, Ventricular epidemiology, Heart Septal Defects, Ventricular mortality, Humans, Hypertension, Pulmonary complications, Infant, Methods, Pulmonary Artery surgery, Heart Septal Defects, Ventricular surgery
- Abstract
The optimal surgical management of ventricular septal defects (SVD) in infancy and particularly in small babies, still remains controversial. Seventy-six infants with VSD as the major cardiac lesion were operated upon from March 1978 to December 1981. Forty-three underwent primary repair with a 9.3% mortality rate. Pulmonary artery banding (PAB) was performed in 33 infants without mortality. Sixteen of them had subsequent debanding and VSD closure, also without mortality. Based on our own experience, our current recommendations are as follows: PAB in severely ill infants under 3 months of age, in infants with multiple or "Swiss-cheese type VSD" and in some cases of VSD with associated anomalies. Early debanding and correction, except in cases with multiple VSDs. Primary repair in infants aged more than 3 months and in some selected younger cases, according to the anatomical location of the defect.
- Published
- 1983
- Full Text
- View/download PDF
21. [Right ventricle-pulmonary artery connection with controlled flow in cardiopathies with interventricular communication and pulmonary atresia-stenosis].
- Author
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García A, Brito JM, Villagrá F, Checa SL, Gómez R, León JP, Sánchez PA, Bermúdez R, Merino G, and Díez Balda JI
- Subjects
- Child, Child, Preschool, Heart Atria surgery, Humans, Pulmonary Valve abnormalities, Blood Vessel Prosthesis, Heart Septal Defects, Ventricular surgery, Palliative Care, Pulmonary Valve surgery, Pulmonary Valve Stenosis surgery
- Published
- 1984
22. [Ectopic pregnancy and hysterectomy].
- Author
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Cervera Flores R, Díaz de León JP, Brunet Meza V, and Vilchis Rodríguez A
- Subjects
- Abortion, Spontaneous complications, Adult, Cesarean Section adverse effects, Female, Humans, Mexico, Pelvic Inflammatory Disease complications, Pregnancy, Pregnancy, Ectopic epidemiology, Pregnancy, Ectopic etiology, Hysterectomy, Pregnancy, Ectopic surgery
- Published
- 1984
23. [Surgical experience in tetralogy of Fallot. 1- or 2-stage correction and our current criteria].
- Author
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Brito JM, Villagra F, León JP, Vizcarra V, Gómez R, Checa SL, Sánchez PA, Herranz B, Vellibre D, and Casillas A
- Subjects
- Adolescent, Adult, Child, Child, Preschool, Extracorporeal Circulation, Humans, Infant, Infant, Newborn, Palliative Care, Reoperation, Risk, Tetralogy of Fallot surgery
- Published
- 1986
24. [Surgical treatment of aortic isthmus hypoplasia in childhood].
- Author
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Alvarez Díaz F, Brito JM, Cordovilla G, De León JP, Sánchez PA, and Martínez Bordiú C
- Subjects
- Age Factors, Blood Vessel Prosthesis methods, Child, Preschool, Humans, Infant, Infant, Newborn, Subclavian Artery transplantation, Suture Techniques, Transplantation, Autologous, Aortic Coarctation surgery
- Published
- 1974
25. [Total hemodilution in children in corrective surgery of congenital heart disease (I). Prospective study in children with a body weight over 12 kg].
- Author
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Villagrá F, de León JP, Vellibre D, Collado R, Alonso A, Gómez R, Sánchez PA, Egurbide N, and Brito JM
- Subjects
- Child, Heart Defects, Congenital blood, Humans, Prospective Studies, Body Weight, Heart Defects, Congenital surgery, Hemodilution
- Published
- 1987
26. [Blalock-Hanlon atrio-septectomy: an outmoded technic? (II) In cardiopathies with atrioventricular or pulmonary obstruction with an intact interventricular septum].
- Author
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Villagrá F, Santalla A, Gómez R, Herraiz I, Maitre MJ, de León JP, Sánchez PA, and Brito JM
- Subjects
- Evaluation Studies as Topic, Humans, Infant, Infant, Newborn, Methods, Heart Septum surgery, Mitral Valve Stenosis surgery, Palliative Care, Pulmonary Valve abnormalities, Tricuspid Valve Stenosis surgery
- Published
- 1984
27. [Total hemodilution in children in corrective surgery of congenital heart disease (II). Prospective study in children with a body weight under 12 kg].
- Author
-
Villagrá F, León JP, Vellibre D, Collado R, Español R, Checa SL, Díaz P, Gómez R, and Brito JM
- Subjects
- Child, Heart Defects, Congenital blood, Humans, Prospective Studies, Body Weight, Heart Defects, Congenital surgery, Hemodilution
- Published
- 1987
28. [Periprosthetic seroma cyst in modified Blalock-Taussig shunt].
- Author
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Gómez R, Villagrá F, Checa SL, Casillas JA, León JP, Sánchez P, and Brito JM
- Subjects
- Cysts diagnostic imaging, Humans, Infant, Radiography, Blood Vessel Prosthesis adverse effects, Cysts etiology, Tetralogy of Fallot surgery
- Published
- 1985
29. [Left anomalous pulmonary venous drainage in the innominate vein].
- Author
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Casillas JA, León JP, Gómez R, Checa SL, Villagrá F, Sánchez PA, Cuesta M, and Brito JM
- Subjects
- Adolescent, Humans, Infant, Male, Pulmonary Circulation, Pulmonary Veins surgery, Brachiocephalic Veins abnormalities, Pulmonary Veins abnormalities
- Published
- 1985
30. [Total transposition of the great vessels: Surgical treatment].
- Author
-
Cordovilla G, Díez FA, Brito JM, León JP, Sánchez PA, Martín VP, and Bordiú CM
- Subjects
- Age Factors, Aortic Coarctation mortality, Aortic Coarctation surgery, Ductus Arteriosus surgery, Ductus Arteriosus, Patent mortality, Evaluation Studies as Topic, Female, Heart Ventricles surgery, Humans, Infant, Infant, Newborn, Male, Methods, Palliative Care, Transposition of Great Vessels mortality, Transposition of Great Vessels surgery
- Abstract
One hundred nine cases of complete transposition of great vessels alone or associated to other abnormalities are presented. In 91 cases a palliative treatment is given and in 18 cases there is a total correction done, depending upon the technique. Surgical indication and the technique used in every case is commented, making special reference to transpositions with ductus arteriosus or associated to coarctation of the aorta. In the 18 cases where we have done a total correction, we comment the surgical procedure of one of them who had a subpulmonary stenosis of the fibromuscular type, which we resolved through left ventriculotomy done on the apex of the ventricle and resecting the stenosis with an electroscalpel, which is a technique we have devised.
- Published
- 1975
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