5 results on '"León, Daniel G"'
Search Results
2. Implications of bipolar voltage mapping and magnetic resonance imaging resolution in biventricular scar characterization after myocardial infarction
- Author
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López-Yunta, Mariña, primary, León, Daniel G, additional, Alfonso-Almazán, José Manuel, additional, Marina-Breysse, Manuel, additional, Quintanilla, Jorge G, additional, Sánchez-González, Javier, additional, Galán-Arriola, Carlos, additional, Cañadas-Godoy, Victoria, additional, Enríquez-Vázquez, Daniel, additional, Torres, Carlos, additional, Ibáñez, Borja, additional, Pérez-Villacastín, Julián, additional, Pérez-Castellano, Nicasio, additional, Jalife, José, additional, Vázquez, Mariano, additional, Aguado-Sierra, Jazmín, additional, and Filgueiras-Rama, David, additional
- Published
- 2018
- Full Text
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3. Implications of bipolar voltage mapping and magnetic resonance imaging resolution in biventricular scar characterization after myocardial infarction.
- Author
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López-Yunta, Mariña, León, Daniel G, Alfonso-Almazán, José Manuel, Marina-Breysse, Manuel, Quintanilla, Jorge G, Sánchez-González, Javier, Galán-Arriola, Carlos, Cañadas-Godoy, Victoria, Enríquez-Vázquez, Daniel, Torres, Carlos, Ibáñez, Borja, Pérez-Villacastín, Julián, Pérez-Castellano, Nicasio, Jalife, José, Vázquez, Mariano, Aguado-Sierra, Jazmín, and Filgueiras-Rama, David
- Abstract
Aims: We aimed to study the differences in biventricular scar characterization using bipolar voltage mapping compared with state-of-the-art in vivo delayed gadolinium-enhanced cardiac magnetic resonance (LGE-CMR) imaging and ex vivo T1 mapping.Methods and Results: Ten pigs with established myocardial infarction (MI) underwent in vivo scar characterization using LGE-CMR imaging and high-density voltage mapping of both ventricles using a 3.5-mm tip catheter. Ex vivo post-contrast T1 mapping provided a high-resolution reference. Voltage maps were registered onto the left and right ventricular (LV and RV) endocardium, and epicardium of CMR-based geometries to compare voltage-derived scars with surface-projected 3D scars. Voltage-derived scar tissue of the LV endocardium and the epicardium resembled surface projections of 3D in vivo and ex vivo CMR-derived scars using 1-mm of surface projection distance. The thinner wall of the RV was especially sensitive to lower resolution in vivo LGE-CMR images, in which differences between normalized low bipolar voltage areas and CMR-derived scar areas did not decrease below a median of 8.84% [interquartile range (IQR) (3.58, 12.70%)]. Overall, voltage-derived scars and surface scar projections from in vivo LGE-CMR sequences showed larger normalized scar areas than high-resolution ex vivo images [12.87% (4.59, 27.15%), 18.51% (11.25, 24.61%), and 9.30% (3.84, 19.59%), respectively], despite having used optimized surface projection distances. Importantly, 43.02% (36.54, 48.72%) of voltage-derived scar areas from the LV endocardium were classified as non-enhanced healthy myocardium using ex vivo CMR imaging.Conclusion: In vivo LGE-CMR sequences and high-density voltage mapping using a conventional linear catheter fail to provide accurate characterization of post-MI scar, limiting the specificity of voltage-based strategies and imaging-guided procedures. [ABSTRACT FROM AUTHOR]- Published
- 2019
- Full Text
- View/download PDF
4. Three-dimensional cardiac fibre disorganization as a novel parameter for ventricular arrhythmia stratification after myocardial infarction.
- Author
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León DG, López-Yunta M, Alfonso-Almazán JM, Marina-Breysse M, Quintanilla JG, Sánchez-González J, Galán-Arriola C, Castro-Núñez F, González-Ferrer JJ, Ibáñez B, Pérez-Villacastín J, Pérez-Castellano N, Fuster V, Jalife J, Vázquez M, Aguado-Sierra J, and Filgueiras-Rama D
- Subjects
- Animals, Risk Assessment, Swine, Cicatrix diagnostic imaging, Cicatrix pathology, Cicatrix physiopathology, Diffusion Tensor Imaging methods, Heart physiopathology, Magnetic Resonance Imaging methods, Myocardial Infarction complications, Myocardium pathology, Tachycardia, Ventricular diagnosis, Tachycardia, Ventricular etiology, Tachycardia, Ventricular physiopathology
- Abstract
Aims: Myocardial infarction (MI) alters cardiac fibre organization with unknown consequences on ventricular arrhythmia. We used diffusion tensor imaging (DTI) of three-dimensional (3D) cardiac fibres and scar reconstructions to identify the main parameters associated with ventricular arrhythmia inducibility and ventricular tachycardia (VT) features after MI., Methods and Results: Twelve pigs with established MI and three controls underwent invasive electrophysiological characterization of ventricular arrhythmia inducibility and VT features. Animal-specific 3D scar and myocardial fibre distribution were obtained from ex vivo high-resolution contrast-enhanced T1 mapping and DTI sequences. Diffusion tensor imaging-derived parameters significantly different between healthy and scarring myocardium, scar volumes, and left ventricular ejection fraction (LVEF) were included for arrhythmia risk stratification and correlation analyses with VT features. Ventricular fibrillation (VF) was the only inducible arrhythmia in 4 out of 12 infarcted pigs and all controls. Ventricular tachycardia was also inducible in the remaining eight pigs during programmed ventricular stimulation. A DTI-based 3D fibre disorganization index (FDI) showed higher disorganization within dense scar regions of VF-only inducible pigs compared with VT inducible animals (FDI: 0.36; 0.36-0.37 vs. 0.32; 0.26-0.33, respectively, P = 0.0485). Ventricular fibrillation induction required lower programmed stimulation aggressiveness in VF-only inducible pigs than VT inducible and control animals. Neither LVEF nor scar volumes differentiated between VF and VT inducible animals. Re-entrant VT circuits were localized within areas of highly disorganized fibres. Moreover, the FDI within heterogeneous scar regions was associated with the median VT cycle length per animal (R2 = 0.5320)., Conclusion: The amount of scar-related cardiac fibre disorganization in DTI sequences is a promising approach for ventricular arrhythmia stratification after MI., (© The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Cardiology.)
- Published
- 2019
- Full Text
- View/download PDF
5. Implications of bipolar voltage mapping and magnetic resonance imaging resolution in biventricular scar characterization after myocardial infarction.
- Author
-
López-Yunta M, León DG, Alfonso-Almazán JM, Marina-Breysse M, Quintanilla JG, Sánchez-González J, Galán-Arriola C, Cañadas-Godoy V, Enríquez-Vázquez D, Torres C, Ibáñez B, Pérez-Villacastín J, Pérez-Castellano N, Jalife J, Vázquez M, Aguado-Sierra J, and Filgueiras-Rama D
- Subjects
- Animals, Arrhythmias, Cardiac etiology, Arrhythmias, Cardiac physiopathology, Cicatrix etiology, Cicatrix pathology, Cicatrix physiopathology, Contrast Media administration & dosage, Disease Models, Animal, Heart Rate, Male, Meglumine administration & dosage, Myocardial Infarction complications, Myocardial Infarction pathology, Myocardial Infarction physiopathology, Organometallic Compounds administration & dosage, Predictive Value of Tests, Reproducibility of Results, Sus scrofa, Action Potentials, Arrhythmias, Cardiac diagnosis, Cicatrix diagnostic imaging, Electrophysiologic Techniques, Cardiac, Heart Conduction System physiopathology, Magnetic Resonance Imaging, Myocardial Infarction diagnostic imaging, Myocardium pathology
- Abstract
Aims: We aimed to study the differences in biventricular scar characterization using bipolar voltage mapping compared with state-of-the-art in vivo delayed gadolinium-enhanced cardiac magnetic resonance (LGE-CMR) imaging and ex vivo T1 mapping., Methods and Results: Ten pigs with established myocardial infarction (MI) underwent in vivo scar characterization using LGE-CMR imaging and high-density voltage mapping of both ventricles using a 3.5-mm tip catheter. Ex vivo post-contrast T1 mapping provided a high-resolution reference. Voltage maps were registered onto the left and right ventricular (LV and RV) endocardium, and epicardium of CMR-based geometries to compare voltage-derived scars with surface-projected 3D scars. Voltage-derived scar tissue of the LV endocardium and the epicardium resembled surface projections of 3D in vivo and ex vivo CMR-derived scars using 1-mm of surface projection distance. The thinner wall of the RV was especially sensitive to lower resolution in vivo LGE-CMR images, in which differences between normalized low bipolar voltage areas and CMR-derived scar areas did not decrease below a median of 8.84% [interquartile range (IQR) (3.58, 12.70%)]. Overall, voltage-derived scars and surface scar projections from in vivo LGE-CMR sequences showed larger normalized scar areas than high-resolution ex vivo images [12.87% (4.59, 27.15%), 18.51% (11.25, 24.61%), and 9.30% (3.84, 19.59%), respectively], despite having used optimized surface projection distances. Importantly, 43.02% (36.54, 48.72%) of voltage-derived scar areas from the LV endocardium were classified as non-enhanced healthy myocardium using ex vivo CMR imaging., Conclusion: In vivo LGE-CMR sequences and high-density voltage mapping using a conventional linear catheter fail to provide accurate characterization of post-MI scar, limiting the specificity of voltage-based strategies and imaging-guided procedures.
- Published
- 2019
- Full Text
- View/download PDF
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