1. Transarterial doxorubicin-eluting beads embolization for the treatment of desmoid fibromatosis in the pubic region
- Author
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Nguyen Huynh Nhat Tuan, MD, Tran Duc Hai, MD, Le Nhat Minh, MD, Ton Long Hoang Than, MD, Pham Dang Tu, MD, Nguyen Van Tien Bao, MD, Le Van Khoa, MD, Thai Ngoc Dang, MD, and Le Van Phuoc, PhD
- Subjects
Desmoid fibromatosis (DFs) ,Doxorubicin-eluting beads embolization ,Chemoemboliztion ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Desmoid fibromatosis (DFs) is rare, low-grade neoplasm. Although it poses no risk of metastasis, DFs exhibits a range of clinical manifestations characterized by local infiltrative growth tendencies and a propensity for recurrence. Despite its nonmalignant nature, DFs can be highly debilitating and occasionally life-threatening, causing severe pain and functional limitations. Traditionally, surgery served as the conventional primary treatment approach; nevertheless, a recent shift in paradigm towards a more conservative management has emerged, accompanied by efforts to standardize the strategy among clinicians. Systemic doxorubicin has been demonstrated to be effective in treating DFs; however, it carries potential risks of adverse effects on the cardiovascular, digestive, and hematologic systems. The novel intravascular intervention employing drug-eluting beads loaded with doxorubicin represents an effective treatment for DFs, optimizing drug delivery to the target lesion and reducing systemic toxicity. In this article, we present a rare case of DFs in the right pubic region treated with transarterial doxorubicin-eluting beads embolization.
- Published
- 2024
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