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2. Insight from an Italian Delphi Consensus on EVAR feasibility outside the instruction for use: the SAFE EVAR Study
- Author
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Sirignano, P, Piffaretti, G, Ceruti, S, Orso, M, Picozzi, M, Ricci, G, Sirignano, A, Taurino, M, Giancarlo Accarino, M, Accrocca, F, Alba, G, Alberti, A, Alberti, V, Allevi, S, Aloisi, F, Amato, B, Amico, A, Andreoli, F, Angiletta, D, Antico, A, Antico, L, Antonello, M, Baccellieri, D, Badalamenti, G, Bafile, G, Baldi, C, Barillà, C, Barillà, D, Bartoli, S, Basile, G, Battaglia, G, Battocchio, C, Belloni, A, Bellosta, R, Benevento, D, Bernardini, G, Bertagna, G, Bertoglio, L, Bianchini Massoni, C, Bisacco, D, Bischetti, M, Boccalon, L, Bonanno, P, Bonardelli, S, Borioni, R, P Borrelli, M, Bozzani, A, M Bracale, U, Camparini, S, Canciglia, A, Canova, F, Capoccia, L, Cappelli, A, Cappiello, P, Carluccio, C, Casalino, A, Casella, F, Casilli, G, Castagno, C, Castelli, P, Castrucci, T, Cavallo, M, Cavazzini, C, Ceccanei, G, Cefalì, P, Celoria, G, Cevolani, M, Chiappa, R, Chisci, E, Comande, C, Compagna, R, Cumino, A, Cuozzo, S, Dalla Caneva, P, D'Alessio, I, D'Arrigo, G, DE Caridi, G, DE Donato, G, DE Donno, G, Desantis, C, DE Santis, F, DE Troia, A, Dezi, T, A Diaco, D, DI Domenico, R, DI Filippo, M, DI Girolamo, A, P Dionisi, C, Dinoto, E, DI Stefano, F, DI STEFANO, L, D'Oria, M, Esposito, A, Esposito, D, Ettore, L, F Fadda, G, Faggioli, G, T Fargion, A, Fazzini, S, Fermani, N, Ferrante, G, Ferrari, M, Ferraro, S, Ferrer, C, Ferretto, L, Ficarelli, I, Filippi, F, Fino, G, Forliti, E, Formiconi, M, Flora, L, Fresilli, M, Frigatti, P, Frigerio, D, Froio, A, Freyrie, A, Furgiuele, S, Gabrielli, R, Gaggiano, A, Galassi, L, Gallelli, G, Gallitto, E, Gallo, F, Galzerano, G, Gargiulo, M, Garriboli, L, G Genadiev, G, Gentile, L, Giaquinta, A, Gibello, L, Grande, R, Grassi, V, Ippoliti, A, Irsara, S, Kahlberg, A, Konstantinos, N, LA Corte, F, Lanza, G, Lauricella, A, Lazzeri, E, Lenti, M, Leopardi, M, Lepidi, S, Li Destri, A, Locatelli, F, Lomazzi, C, Lombardi, F, Lorido, A, Maggiore, C, Mansour, W, Marcucci, V, Mascia, D, Massara, M, Mastrangelo, G, Margheritini, C, Maritati, G, Martelli, E, Martinelli, O, Marzano, A, Mauri, F, Mazzacaro, D, Melloni, A, Mezzetti, R, Michelagnoli, S, Migliara, B, Migliari, M, Millarelli, M, Misuraca, M, Modugno, P, Moniaci, D, Montelione, N, Monti, A, Monzio-Compagnoni, N, Moro, M, Mortola, L, Mozzetta, G, Musilli, A, Nano, G, Occhiuto, M, M Oddi, F, Orellana, B, Orlando, P, Orrico, M, A Pacilè, M, Pagliariccio, G, Pallini, C, Palmieri, A, Palughi, M, Panagrasso, M, Panzano, C, Panzera, C, Pascucci, F, Pasqua, R, Pasquetti, L, Pasqui, E, Pecchio, A, Pecoraro, F, Peluttiero, I, F Pennetta, F, Perini, P, Piazza, M, Pini, R, Pipito, N, Pranteda, C, Praquin, B, Pratesi, C, F Porreca, C, Pulli, R, Reina, N, F Rinaldi, L, Rizzo, L, Romano, E, Ronchey, S, Ruggiero, F, Ruggiero, M, Sallustro, M, Saviane, G, Sbarigia, E, Scovazzi, P, M Segramor, V, Sena, G, Setacci, C, Setacci, F, E Setteducati, C, M Settembrini, A, Siani, A, Sica, S, Speziale, F, Squizzato, F, Stella, N, Stilo, F, Sufali, G, Tanda, E, Tinelli, G, Tomei, F, Tosti, F, Trimarchi, S, Troisi, N, Tshomba, Y, Turchino, D, Turriziani, V, Ucci, A, Veneto, V, Veraldi, G, Wiesel, P, Xodo, A, Zacà, S, Zaraca, F, Zenunaj, G, SIRIGNANO, Pasqualino, PIFFARETTI, Gabriele, CERUTI, Silvia, ORSO, Massimiliano, PICOZZI, Mario, RICCI, Giovanna, SIRIGNANO, Ascanio, TAURINO, Maurizio, Giancarlo Accarino, Maurizio, Accrocca, Federico, Alba, Giuseppe, Alberti, Antonino, Alberti, Vittorio, Allevi, Sara, Aloisi, Francesco, Amato, Bruno, Amico, Alessio, Andreoli, Francesco, Angiletta, Domenico, Antico, Antonio, Antico, Lorenzo, Antonello, Michele, Baccellieri, Domenico, Badalamenti, Giovanni, Bafile, Gennaro, Baldi, Claudio, Barillà, Chiara, Barillà, David, Bartoli, Stefano, Basile, Giusi, Battaglia, Giuseppe, Battocchio, Cesare, Belloni, Ailin, Bellosta, Raffello, Benevento, Domenico, Bernardini, Giulia, Bertagna, Giulia, Bertoglio, Luca, Bianchini Massoni, Claudio, Bisacco, Daniel, Bischetti, Michelangelo, Boccalon, Luca, Bonanno, Paolo, Bonardelli, Stefano, Borioni, Raul, P Borrelli, Maria, Bozzani, Antonio, M Bracale, Umberto, Camparini, Stefano, Canciglia, Aldo, Canova, Francesco, Capoccia, Laura, Cappelli, Alessandro, Cappiello, Pierlugi, Carluccio, Chiara, Casalino, Alfonso, Casella, Francesco, Casilli, Giulia, Castagno, Claudio, Castelli, Patrizio, Castrucci, Tommaso, Cavallo, Matteo, Cavazzini, Carlo, Ceccanei, Gianluca, Cefalì, Pietro, Celoria, Gianni, Cevolani, Mauro, Chiappa, Roberto, Chisci, Emiliano, Comande, Carlo, Compagna, Rita, Cumino, Andrea, Cuozzo, Simone, Dalla Caneva, Patrizia, D'Alessio, Ilaria, D'Arrigo, Giuseppe, DE Caridi, Giovanni, DE Donato, Gianmarco, DE Donno, Gabriele, Desantis, Claudio, DE Santis, Francesco, DE Troia, Alessandro, Dezi, Tommaso, A Diaco, Domenico, DI Domenico, Rossella, DI Filippo, Michele, DI Girolamo, Alessia, P Dionisi, Carlo, Dinoto, Ettore, DI Stefano, Francesco, DI STEFANO, Lucia, D'Oria, Mario, Esposito, Andrea, Esposito, Davide, Ettore, Ludovica, F Fadda, Gian, Faggioli, Gianluca, T Fargion, Aaron, Fazzini, Stefano, Fermani, Nicoletta, Ferrante, Giulia, Ferrari, Mauro, Ferraro, Stafanio, Ferrer, Ciro, Ferretto, Luca, Ficarelli, Ilaria, Filippi, Federico, Fino, Gianluigi, Forliti, Enzo, Formiconi, Martina, Flora, Loris, Fresilli, Mauro, Frigatti, Paolo, Frigerio, Dalmazio, Froio, Alberto, Freyrie, Antonio, Furgiuele, Sergio, Gabrielli, Roberto, Gaggiano, Andrea, Galassi, Luca, Gallelli, Giuseppe, Gallitto, Enrico, Gallo, Francesco, Galzerano, Giuseppe, Gargiulo, Mauro, Garriboli, Luca, G Genadiev, Genadi, Gentile, Lucia, Giaquinta, Alessia, Gibello, Lorenzo, Grande, Raffaele, Grassi, Viviana, Ippoliti, Arnaldo, Irsara, Sandro, Kahlberg, Andrea, Konstantinos, Nikolakopoulos, LA Corte, Francesco, Lanza, Gaetano, Lauricella, Antonio, Lazzeri, Elisa, Lenti, Massimo, Leopardi, Marco, Lepidi, Sandro, Li Destri, Andrea, Locatelli, Federica, Lomazzi, Chiara, Lombardi, Francesco, Lorido, Antonio, Maggiore, Claudia, Mansour, Wassim, Marcucci, Vittorio, Mascia, Daniele, Massara, Mafalda, Mastrangelo, Giovanni, Margheritini, Costanza, Maritati, Gabriele, Martelli, Eugenio, Martinelli, Ombretta, Marzano, Antonio, Mauri, Francesca, Mazzacaro, Daniela, Melloni, Andrea, Mezzetti, Roberto, Michelagnoli, Stefano, Migliara, Bruno, Migliari, Mattia, Millarelli, Massimiliano, Misuraca, Maria, Modugno, Pietro, Moniaci, Diego, Montelione, Nunzio, Monti, Andrea, Monzio-Compagnoni, Nicola, Moro, Mario, Mortola, Lorenzo, Mozzetta, Gaddiel, Musilli, Aldo, Nano, Giovanni, Occhiuto, Mariateresa, M Oddi, Fabio, Orellana, Bernardo, Orlando, Paola, Orrico, Matteo, A Pacilè, Maria, Pagliariccio, Gabriele, Pallini, Cristina, Palmieri, Armando, Palughi, Martina, Panagrasso, Marco, Panzano, Claudia, Panzera, Chiara, Pascucci, Francesco, Pasqua, Rocco, Pasquetti, Leonardo, Pasqui, Eduardo, Pecchio, Alberto, Pecoraro, Felice, Peluttiero, Ilaria, F Pennetta, Federico, Perini, Paolo, Piazza, Michele, Pini, Rodolfo, Pipito, Narayana, Pranteda, Chiara, Praquin, Barbara, Pratesi, Carlo, F Porreca, Carlo, Pulli, Raffaele, Reina, Nicola, F Rinaldi, Luigi, Rizzo, Luigi, Romano, Elisa, Ronchey, Sonia, Ruggiero, Federica, Ruggiero, Massimo, Sallustro, Marianna, Saviane, Gianna, Sbarigia, Enrico, Scovazzi, Paolo, M Segramor, Vittorio, Sena, Giuseppe, Setacci, Carlo, Setacci, Francesco, E Setteducati, Carmen, M Settembrini, Alberto, Siani, Andrea, Sica, Simona, Speziale, Francesco, Squizzato, Francesco, Stella, Nazzareno, Stilo, Francesco, Sufali, Gemmi, Tanda, Elisabetta, Tinelli, Giovanni, Tomei, Francesca, Tosti, Filomena, Trimarchi, Santi, Troisi, Nicola, Tshomba, Yamume, Turchino, Davide, Turriziani, Valerio, Ucci, Alessandro, Veneto, Vincenzo, Veraldi, Gianfranco, Wiesel, Paola, Xodo, Andrea, Zacà, Sergio, Zaraca, Francesco, Zenunaj, Glaudiol, Sirignano, P, Piffaretti, G, Ceruti, S, Orso, M, Picozzi, M, Ricci, G, Sirignano, A, Taurino, M, Giancarlo Accarino, M, Accrocca, F, Alba, G, Alberti, A, Alberti, V, Allevi, S, Aloisi, F, Amato, B, Amico, A, Andreoli, F, Angiletta, D, Antico, A, Antico, L, Antonello, M, Baccellieri, D, Badalamenti, G, Bafile, G, Baldi, C, Barillà, C, Barillà, D, Bartoli, S, Basile, G, Battaglia, G, Battocchio, C, Belloni, A, Bellosta, R, Benevento, D, Bernardini, G, Bertagna, G, Bertoglio, L, Bianchini Massoni, C, Bisacco, D, Bischetti, M, Boccalon, L, Bonanno, P, Bonardelli, S, Borioni, R, P Borrelli, M, Bozzani, A, M Bracale, U, Camparini, S, Canciglia, A, Canova, F, Capoccia, L, Cappelli, A, Cappiello, P, Carluccio, C, Casalino, A, Casella, F, Casilli, G, Castagno, C, Castelli, P, Castrucci, T, Cavallo, M, Cavazzini, C, Ceccanei, G, Cefalì, P, Celoria, G, Cevolani, M, Chiappa, R, Chisci, E, Comande, C, Compagna, R, Cumino, A, Cuozzo, S, Dalla Caneva, P, D'Alessio, I, D'Arrigo, G, DE Caridi, G, DE Donato, G, DE Donno, G, Desantis, C, DE Santis, F, DE Troia, A, Dezi, T, A Diaco, D, DI Domenico, R, DI Filippo, M, DI Girolamo, A, P Dionisi, C, Dinoto, E, DI Stefano, F, DI STEFANO, L, D'Oria, M, Esposito, A, Esposito, D, Ettore, L, F Fadda, G, Faggioli, G, T Fargion, A, Fazzini, S, Fermani, N, Ferrante, G, Ferrari, M, Ferraro, S, Ferrer, C, Ferretto, L, Ficarelli, I, Filippi, F, Fino, G, Forliti, E, Formiconi, M, Flora, L, Fresilli, M, Frigatti, P, Frigerio, D, Froio, A, Freyrie, A, Furgiuele, S, Gabrielli, R, Gaggiano, A, Galassi, L, Gallelli, G, Gallitto, E, Gallo, F, Galzerano, G, Gargiulo, M, Garriboli, L, G Genadiev, G, Gentile, L, Giaquinta, A, Gibello, L, Grande, R, Grassi, V, Ippoliti, A, Irsara, S, Kahlberg, A, Konstantinos, N, LA Corte, F, Lanza, G, Lauricella, A, Lazzeri, E, Lenti, M, Leopardi, M, Lepidi, S, Li Destri, A, Locatelli, F, Lomazzi, C, Lombardi, F, Lorido, A, Maggiore, C, Mansour, W, Marcucci, V, Mascia, D, Massara, M, Mastrangelo, G, Margheritini, C, Maritati, G, Martelli, E, Martinelli, O, Marzano, A, Mauri, F, Mazzacaro, D, Melloni, A, Mezzetti, R, Michelagnoli, S, Migliara, B, Migliari, M, Millarelli, M, Misuraca, M, Modugno, P, Moniaci, D, Montelione, N, Monti, A, Monzio-Compagnoni, N, Moro, M, Mortola, L, Mozzetta, G, Musilli, A, Nano, G, Occhiuto, M, M Oddi, F, Orellana, B, Orlando, P, Orrico, M, A Pacilè, M, Pagliariccio, G, Pallini, C, Palmieri, A, Palughi, M, Panagrasso, M, Panzano, C, Panzera, C, Pascucci, F, Pasqua, R, Pasquetti, L, Pasqui, E, Pecchio, A, Pecoraro, F, Peluttiero, I, F Pennetta, F, Perini, P, Piazza, M, Pini, R, Pipito, N, Pranteda, C, Praquin, B, Pratesi, C, F Porreca, C, Pulli, R, Reina, N, F Rinaldi, L, Rizzo, L, Romano, E, Ronchey, S, Ruggiero, F, Ruggiero, M, Sallustro, M, Saviane, G, Sbarigia, E, Scovazzi, P, M Segramor, V, Sena, G, Setacci, C, Setacci, F, E Setteducati, C, M Settembrini, A, Siani, A, Sica, S, Speziale, F, Squizzato, F, Stella, N, Stilo, F, Sufali, G, Tanda, E, Tinelli, G, Tomei, F, Tosti, F, Trimarchi, S, Troisi, N, Tshomba, Y, Turchino, D, Turriziani, V, Ucci, A, Veneto, V, Veraldi, G, Wiesel, P, Xodo, A, Zacà, S, Zaraca, F, Zenunaj, G, SIRIGNANO, Pasqualino, PIFFARETTI, Gabriele, CERUTI, Silvia, ORSO, Massimiliano, PICOZZI, Mario, RICCI, Giovanna, SIRIGNANO, Ascanio, TAURINO, Maurizio, Giancarlo Accarino, Maurizio, Accrocca, Federico, Alba, Giuseppe, Alberti, Antonino, Alberti, Vittorio, Allevi, Sara, Aloisi, Francesco, Amato, Bruno, Amico, Alessio, Andreoli, Francesco, Angiletta, Domenico, Antico, Antonio, Antico, Lorenzo, Antonello, Michele, Baccellieri, Domenico, Badalamenti, Giovanni, Bafile, Gennaro, Baldi, Claudio, Barillà, Chiara, Barillà, David, Bartoli, Stefano, Basile, Giusi, Battaglia, Giuseppe, Battocchio, Cesare, Belloni, Ailin, Bellosta, Raffello, Benevento, Domenico, Bernardini, Giulia, Bertagna, Giulia, Bertoglio, Luca, Bianchini Massoni, Claudio, Bisacco, Daniel, Bischetti, Michelangelo, Boccalon, Luca, Bonanno, Paolo, Bonardelli, Stefano, Borioni, Raul, P Borrelli, Maria, Bozzani, Antonio, M Bracale, Umberto, Camparini, Stefano, Canciglia, Aldo, Canova, Francesco, Capoccia, Laura, Cappelli, Alessandro, Cappiello, Pierlugi, Carluccio, Chiara, Casalino, Alfonso, Casella, Francesco, Casilli, Giulia, Castagno, Claudio, Castelli, Patrizio, Castrucci, Tommaso, Cavallo, Matteo, Cavazzini, Carlo, Ceccanei, Gianluca, Cefalì, Pietro, Celoria, Gianni, Cevolani, Mauro, Chiappa, Roberto, Chisci, Emiliano, Comande, Carlo, Compagna, Rita, Cumino, Andrea, Cuozzo, Simone, Dalla Caneva, Patrizia, D'Alessio, Ilaria, D'Arrigo, Giuseppe, DE Caridi, Giovanni, DE Donato, Gianmarco, DE Donno, Gabriele, Desantis, Claudio, DE Santis, Francesco, DE Troia, Alessandro, Dezi, Tommaso, A Diaco, Domenico, DI Domenico, Rossella, DI Filippo, Michele, DI Girolamo, Alessia, P Dionisi, Carlo, Dinoto, Ettore, DI Stefano, Francesco, DI STEFANO, Lucia, D'Oria, Mario, Esposito, Andrea, Esposito, Davide, Ettore, Ludovica, F Fadda, Gian, Faggioli, Gianluca, T Fargion, Aaron, Fazzini, Stefano, Fermani, Nicoletta, Ferrante, Giulia, Ferrari, Mauro, Ferraro, Stafanio, Ferrer, Ciro, Ferretto, Luca, Ficarelli, Ilaria, Filippi, Federico, Fino, Gianluigi, Forliti, Enzo, Formiconi, Martina, Flora, Loris, Fresilli, Mauro, Frigatti, Paolo, Frigerio, Dalmazio, Froio, Alberto, Freyrie, Antonio, Furgiuele, Sergio, Gabrielli, Roberto, Gaggiano, Andrea, Galassi, Luca, Gallelli, Giuseppe, Gallitto, Enrico, Gallo, Francesco, Galzerano, Giuseppe, Gargiulo, Mauro, Garriboli, Luca, G Genadiev, Genadi, Gentile, Lucia, Giaquinta, Alessia, Gibello, Lorenzo, Grande, Raffaele, Grassi, Viviana, Ippoliti, Arnaldo, Irsara, Sandro, Kahlberg, Andrea, Konstantinos, Nikolakopoulos, LA Corte, Francesco, Lanza, Gaetano, Lauricella, Antonio, Lazzeri, Elisa, Lenti, Massimo, Leopardi, Marco, Lepidi, Sandro, Li Destri, Andrea, Locatelli, Federica, Lomazzi, Chiara, Lombardi, Francesco, Lorido, Antonio, Maggiore, Claudia, Mansour, Wassim, Marcucci, Vittorio, Mascia, Daniele, Massara, Mafalda, Mastrangelo, Giovanni, Margheritini, Costanza, Maritati, Gabriele, Martelli, Eugenio, Martinelli, Ombretta, Marzano, Antonio, Mauri, Francesca, Mazzacaro, Daniela, Melloni, Andrea, Mezzetti, Roberto, Michelagnoli, Stefano, Migliara, Bruno, Migliari, Mattia, Millarelli, Massimiliano, Misuraca, Maria, Modugno, Pietro, Moniaci, Diego, Montelione, Nunzio, Monti, Andrea, Monzio-Compagnoni, Nicola, Moro, Mario, Mortola, Lorenzo, Mozzetta, Gaddiel, Musilli, Aldo, Nano, Giovanni, Occhiuto, Mariateresa, M Oddi, Fabio, Orellana, Bernardo, Orlando, Paola, Orrico, Matteo, A Pacilè, Maria, Pagliariccio, Gabriele, Pallini, Cristina, Palmieri, Armando, Palughi, Martina, Panagrasso, Marco, Panzano, Claudia, Panzera, Chiara, Pascucci, Francesco, Pasqua, Rocco, Pasquetti, Leonardo, Pasqui, Eduardo, Pecchio, Alberto, Pecoraro, Felice, Peluttiero, Ilaria, F Pennetta, Federico, Perini, Paolo, Piazza, Michele, Pini, Rodolfo, Pipito, Narayana, Pranteda, Chiara, Praquin, Barbara, Pratesi, Carlo, F Porreca, Carlo, Pulli, Raffaele, Reina, Nicola, F Rinaldi, Luigi, Rizzo, Luigi, Romano, Elisa, Ronchey, Sonia, Ruggiero, Federica, Ruggiero, Massimo, Sallustro, Marianna, Saviane, Gianna, Sbarigia, Enrico, Scovazzi, Paolo, M Segramor, Vittorio, Sena, Giuseppe, Setacci, Carlo, Setacci, Francesco, E Setteducati, Carmen, M Settembrini, Alberto, Siani, Andrea, Sica, Simona, Speziale, Francesco, Squizzato, Francesco, Stella, Nazzareno, Stilo, Francesco, Sufali, Gemmi, Tanda, Elisabetta, Tinelli, Giovanni, Tomei, Francesca, Tosti, Filomena, Trimarchi, Santi, Troisi, Nicola, Tshomba, Yamume, Turchino, Davide, Turriziani, Valerio, Ucci, Alessandro, Veneto, Vincenzo, Veraldi, Gianfranco, Wiesel, Paola, Xodo, Andrea, Zacà, Sergio, Zaraca, Francesco, and Zenunaj, Glaudiol
- Abstract
BACKGROUND: The SAfety and FEasibility of standard EVAR outside the instruction for use (SAFE-EVAR) Study was designed to define the attitude of Italian vascular surgeons towards the use of standard endovascular repair (EVAR) for infrarenal abdominal aortic aneurysm (AAA) outside the instruction for use (IFU) through a Delphi consensus endorsed by the Italian Society of Vascular and Endovascular Surgery (Società Italiana di Chirurgia Vascolare ed Endovascolare - SI CVE). METHODS : A questionnaire consisting of 26 statements was developed, validated by an 18-member Advisory Board, and then sent to 600 Italian vascular surgeons. The Delphi process was structured in three subsequent rounds which took place between April and June 2023. In the first two rounds, respondents could indicate one of the following five degrees of agreement: 1) strongly agree; 2) partially agree; 3) neither agree nor disagree; 4) partially disagree; 5) strongly disagree; while in the third round only three different choices were proposed: 1) agree; 2) neither agree nor disagree; 3) disagree. We considered the consensus reached when ≥70% of respondents agreed on one of the options. After the conclusion of each round, a report describing the percentage distribution of the answers was sent to all the participants. RESULTS: Two-hundred-forty-four (40.6%) Italian Vascular Surgeons agreed to participate the first round of the Delphi Consensus; the second and the third rounds of the Delphi collected 230 responders (94.3% of the first-round responders). Four statements (15.4%) reached a consensus in the first rounds. Among the 22 remaining statements, one more consensus (3.8%) was achieved in the second round. Finally, seven more statements (26.9%) reached a consensus in the simplified last round. Globally, a consensus was reached for almost half of the proposed statements (46.1%). CONCLUSIONS: The relatively low consensus rate obtained in this Delphi seems to confirm the discrepancy between Guideline
- Published
- 2024
3. Nuclear Medicine Imaging of Cardiovascular Implantable Electronic Device Infection and Endocarditis
- Author
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Erba, P. A., primary, Sollini, M., additional, Zanca, R., additional, Marciano, A., additional, Vitali, S., additional, Bartoli, F., additional, and Lazzeri, E., additional
- Published
- 2019
- Full Text
- View/download PDF
4. Alternative Nuclear Imaging Tools for Infection Imaging
- Author
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Erba, P, Bartoli, F, Sollini, M, Raffaella, B, Zanca, R, Enrica, E, Lazzeri, E, Erba P. A., Bartoli F., Sollini M., Raffaella B., Zanca R., Enrica E., Lazzeri E., Erba, P, Bartoli, F, Sollini, M, Raffaella, B, Zanca, R, Enrica, E, Lazzeri, E, Erba P. A., Bartoli F., Sollini M., Raffaella B., Zanca R., Enrica E., and Lazzeri E.
- Abstract
Purpose of Review: Cardiovascular infections are serious disease associated with high morbidity and mortality. Their diagnosis is challenging, requiring a proper management for a prompt recognition of the clinical manifestations, and a multidisciplinary approach involving cardiologists, cardiothoracic surgeons, infectious diseases specialist, imagers, and microbiologists. Imaging plays a central role in the diagnostic workout, including molecular imaging techniques. In this setting, two different strategies might be used to image infections: the first is based on the use of agents targeting the microorganism responsible for the infection. Alternatively, we can target the components of the pathophysiological changes of the inflammatory process and/or the host response to the infectious pathogen can be considered. Understanding the strength and limitations of each strategy is crucial to select the most appropriate imaging tool. Recent Findings: Currently, multislice computed tomography (MSCT) and nuclear imaging (18F-fluorodeoxyglucose positron emission tomography/computed tomography, and leucocyte scintigraphy) are part of the diagnostic strategies. The main role of nuclear medicine imaging (PET/CT and SPECT/CT) is the confirmation of valve/CIED involvement and/or associated perivalvular infection and the detection of distant septic embolism. Proper patients’ preparation, imaging acquisition, and reconstruction as well as imaging reading are crucial to maximize the diagnostic information. Summary: In this manuscript, we described the use of molecular imaging techniques, in particular WBC imaging, in patients with infective endocarditis, cardiovascular implantable electronic device infections, and infections of composite aortic graft, underlying the strength and limitations of such approached as compared to the other imaging modalities.
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- 2022
5. Gamma camera imaging of infectious endocarditis
- Author
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Giammarile, F, Gnanasegaran, G, Erba, P, Sollini, M, Zanca, R, Bartoli, F, Lazzeri, E, Erba P. A., Sollini M., Zanca R., Bartoli F., Lazzeri E., Giammarile, F, Gnanasegaran, G, Erba, P, Sollini, M, Zanca, R, Bartoli, F, Lazzeri, E, Erba P. A., Sollini M., Zanca R., Bartoli F., and Lazzeri E.
- Abstract
Infective endocarditis is associated with high morbidity and mortality. Early diagnosis is crucial for adequate patient's management, as early treatment improves the prognosis. Hardly diagnosed on the basis of a single symptom, sign or diagnostic test. Rather, the diagnosis requires a multidisciplinary discussion in addition to the integration of clinical signs, microbiology data and imaging data. The application of multimodality imaging, including molecular imaging techniques has improved the sensitivity to detect IE, also allowing for early detection of septic emboli and metastatic infections before these become clinically apparent. In this chapter, we will describe the main epidemiological, clinical and diagnostic challenges in IE with particular regard to the role of WBC SPECT/CT. In addition, the needs of proper hybrid equipment, dedicated imaging acquisition protocols, specific expertise for imaging reading and imaging interpretations in this field are discussed, emphasizing the need of a specific reference framework within a Cardiovascular Multidisciplinary Team Approach.
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- 2022
6. PET imaging in cardiovascular infections
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Macapinlac, H, Treglia , G, Signore, A, Sollini, M, Bartoli, F, Zanca, R, Lazzeri, E, Slart, R, Erba, P, Sollini M., Bartoli F., Zanca R., Lazzeri E., Slart R. H. J. A., Erba P. A., Macapinlac, H, Treglia , G, Signore, A, Sollini, M, Bartoli, F, Zanca, R, Lazzeri, E, Slart, R, Erba, P, Sollini M., Bartoli F., Zanca R., Lazzeri E., Slart R. H. J. A., and Erba P. A.
- Abstract
Cardiovascular (CVS) infections are associated with high morbidity and mortality. Early diagnosis is crucial for adequate patient's management, as early treatment improves the prognosis. Hardly they are diagnosed on the basis of a single symptom, sign or diagnostic test, being a multidisciplinary discussion in addition to the integration of clinical signs, microbiology data and imaging data necessary in many cases. The application of multimodality imaging, including molecular imaging techniques has improved the sensitivity to detect infections involving heart valves and vessels and implanted cardiovascular devices while also allowing for early detection of septic emboli and metastatic infections before these become clinically apparent. In this chapter, we describe the role of WBC SPECT/CT and [18F] FDG PET/CT in most clinically relevant CVS infections including dedicated imaging acquisition protocols, specific imaging reading and interpretations criteria, emphasizing the need of a specific reference framework within a Cardiovascular Multidisciplinary Team Approach to select the best test or combination of tests for each specific clinical situation.
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- 2022
7. Clinical indications, image acquisition and data interpretation for white blood cells and anti-granulocyte monoclonal antibody scintigraphy: an EANM procedural guideline
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Signore, A., Jamar, F., Israel, O., Buscombe, J., Martin-Comin, J., and Lazzeri, E.
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- 2018
- Full Text
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8. WCN23-0619 TUBULAR CELL POLYPLOIDY PROTECTS FROM LETHAL ACUTE KIDNEY INJURY BUT PROMOTES CONSEQUENT CHRONIC KIDNEY DISEASE
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De Chiara, L., primary, Lazzeri, E., additional, and Romagnani, P., additional
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- 2023
- Full Text
- View/download PDF
9. Novel insights on the relationship between T-tubular defects and contractile dysfunction in a mouse model of hypertrophic cardiomyopathy
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Crocini, C., Ferrantini, C., Scardigli, M., Coppini, R., Mazzoni, L., Lazzeri, E., Pioner, J.M., Scellini, B., Guo, A., Song, L.S., Yan, P., Loew, L.M., Tardiff, J., Tesi, C., Vanzi, F., Cerbai, E., Pavone, F.S., Sacconi, L., and Poggesi, C.
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- 2016
- Full Text
- View/download PDF
10. Roadmap Scienza Aperta
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Castelli D., De Simone G., Cancedda F., Candela L., Colcelli V., Conte R., Di Donato F., Giannini S., Lazzeri E., Mangiaracina S., and Ranchino M. A.
- Subjects
Open Access ,Open Science ,Roadmap - Abstract
La scienza aperta è un paradigma che influenza le pratiche di produzione e condivisione di conoscenza. Obiettivo di questa roadmap è delineare un percorso per la realizzazione e diffusione di pratiche e politiche di scienza aperta all'interno del Consiglio Nazionale delle Ricerche.
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- 2023
11. Produzione e verifiche di qualità dei radiofarmaci estemporanei da materiale autologo
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Lazzeri, E., Viglietti, A. L., De Palma, D., Maioli, C., and Lucignani, Giovanni
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- 2011
- Full Text
- View/download PDF
12. State of the art of 18F-FDG PET/CT application in inflammation and infection: a guide for image acquisition and interpretation
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Casali, M, Lauri, C, Altini, C, Bertagna, F, Cassarino, G, Cistaro, A, Erba, P, Ferrari, C, Mainolfi, C, Palucci, A, Prandini, N, Baldari, S, Bartoli, F, Bartolomei, M, D'Antonio, A, Dondi, F, Gandolfo, P, Giordano, A, Laudicella, R, Massollo, M, Nieri, A, Piccardo, A, Vendramin, L, Muratore, F, Lavelli, V, Albano, D, Burroni, L, Cuocolo, A, Evangelista, L, Lazzeri, E, Quartuccio, N, Rossi, B, Rubini, G, Sollini, M, Versari, A, Signore, A, Casali M., Lauri C., Altini C., Bertagna F., Cassarino G., Cistaro A., Erba P. A., Ferrari C., Mainolfi C. G., Palucci A., Prandini N., Baldari S., Bartoli F., Bartolomei M., D'Antonio A., Dondi F., Gandolfo P., Giordano A., Laudicella R., Massollo M., Nieri A., Piccardo A., Vendramin L., Muratore F., Lavelli V., Albano D., Burroni L., Cuocolo A., Evangelista L., Lazzeri E., Quartuccio N., Rossi B., Rubini G., Sollini M., Versari A., Signore A., Casali, M, Lauri, C, Altini, C, Bertagna, F, Cassarino, G, Cistaro, A, Erba, P, Ferrari, C, Mainolfi, C, Palucci, A, Prandini, N, Baldari, S, Bartoli, F, Bartolomei, M, D'Antonio, A, Dondi, F, Gandolfo, P, Giordano, A, Laudicella, R, Massollo, M, Nieri, A, Piccardo, A, Vendramin, L, Muratore, F, Lavelli, V, Albano, D, Burroni, L, Cuocolo, A, Evangelista, L, Lazzeri, E, Quartuccio, N, Rossi, B, Rubini, G, Sollini, M, Versari, A, Signore, A, Casali M., Lauri C., Altini C., Bertagna F., Cassarino G., Cistaro A., Erba P. A., Ferrari C., Mainolfi C. G., Palucci A., Prandini N., Baldari S., Bartoli F., Bartolomei M., D'Antonio A., Dondi F., Gandolfo P., Giordano A., Laudicella R., Massollo M., Nieri A., Piccardo A., Vendramin L., Muratore F., Lavelli V., Albano D., Burroni L., Cuocolo A., Evangelista L., Lazzeri E., Quartuccio N., Rossi B., Rubini G., Sollini M., Versari A., and Signore A.
- Abstract
Aim: The diagnosis, severity and extent of a sterile inflammation or a septic infection could be challenging since there is not one single test able to achieve an accurate diagnosis. The clinical use of 18F-fluorodeoxyglucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) imaging in the assessment of inflammation and infection is increasing worldwide. The purpose of this paper is to achieve an Italian consensus document on [18F]FDG PET/CT or PET/MRI in inflammatory and infectious diseases, such as osteomyelitis (OM), prosthetic joint infections (PJI), infective endocarditis (IE), prosthetic valve endocarditis (PVE), cardiac implantable electronic device infections (CIEDI), systemic and cardiac sarcoidosis (SS/CS), diabetic foot (DF), fungal infections (FI), tuberculosis (TBC), fever and inflammation of unknown origin (FUO/IUO), pediatric infections (PI), inflammatory bowel diseases (IBD), spine infections (SI), vascular graft infections (VGI), large vessel vasculitis (LVV), retroperitoneal fibrosis (RF) and COVID-19 infections. Methods: In September 2020, the inflammatory and infectious diseases focus group (IIFG) of the Italian Association of Nuclear Medicine (AIMN) proposed to realize a procedural paper about the clinical applications of [18F]FDG PET/CT or PET/MRI in inflammatory and infectious diseases. The project was carried out thanks to the collaboration of 13 Italian nuclear medicine centers, with a consolidate experience in this field. With the endorsement of AIMN, IIFG contacted each center, and the pediatric diseases focus group (PDFC). IIFG provided for each team involved, a draft with essential information regarding the execution of [18F]FDG PET/CT or PET/MRI scan (i.e., indications, patient preparation, standard or specific acquisition modalities, interpretation criteria, reporting methods, pitfalls and artifacts), by limiting the literature research to the last 20 years. Moreover, some clinical cases were required from each
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- 2021
13. Comparison of MRI, [18F]FDG PET/CT, and 99mTc-UBI 29-41 scintigraphy for postoperative spondylodiscitis—a prospective multicenter study
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Paez, D, Sathekge, M, Douis, H, Giammarile, F, Fatima, S, Dhal, A, Puri, S, Erba, P, Lazzeri, E, Ferrando, R, Filho, P, Magboo, V, Morozova, O, Nunez, R, Pellet, O, Mariani, G, Paez D., Sathekge M. M., Douis H., Giammarile F., Fatima S., Dhal A., Puri S. K., Erba P. A., Lazzeri E., Ferrando R., Filho P. A., Magboo V. P., Morozova O., Nunez R., Pellet O., Mariani G., Paez, D, Sathekge, M, Douis, H, Giammarile, F, Fatima, S, Dhal, A, Puri, S, Erba, P, Lazzeri, E, Ferrando, R, Filho, P, Magboo, V, Morozova, O, Nunez, R, Pellet, O, Mariani, G, Paez D., Sathekge M. M., Douis H., Giammarile F., Fatima S., Dhal A., Puri S. K., Erba P. A., Lazzeri E., Ferrando R., Filho P. A., Magboo V. P., Morozova O., Nunez R., Pellet O., and Mariani G.
- Abstract
Purpose: Postoperative infection still constitutes an important complication of spine surgery, and the optimal imaging modality for diagnosing postoperative spine infection has not yet been established. The aim of this prospective multicenter study was to assess the diagnostic performance of three imaging modalities in patients with suspected postoperative spine infection: MRI, [18F]FDG PET/CT, and SPECT/CT with 99mTc-UBI 29-41. Methods: Patients had to undergo at least 2 out of the 3 imaging modalities investigated. Sixty-three patients enrolled fulfilled such criteria and were included in the final analysis: 15 patients underwent all 3 imaging modalities, while 48 patients underwent at least 2 imaging modalities (MRI + PET/CT, MRI + SPECT/CT, or PET/CT + SPECT/CT). Final diagnosis of postoperative spinal infection was based either on biopsy or on follow-up for at least 6 months. The MRI, PET/CT, and SPECT/CT scans were read blindly by experts at designated core laboratories. Spine surgery included metallic implants in 46/63 patients (73%); postoperative spine infection was diagnosed in 30/63 patients (48%). Results: Significant discriminants between infection and no infection included fever (P = 0.041), discharge at the wound site (P < 0.0001), and elevated CRP (P = 0.042). There was no difference in the frequency of infection between patients who underwent surgery involving spinal implants versus those who did not. The diagnostic performances of MRI and [18F]FDG PET/CT analyzed as independent groups were equivalent, with values of the area under the ROC curve equal to 0.78 (95% CI: 0.64–0.92) and 0.80 (95% CI: 0.64–0.98), respectively. SPECT/CT with 99mTc-UBI 29-41 yielded either unacceptably low sensitivity (44%) or unacceptably low specificity (41%) when adopting more or less stringent interpretation criteria. The best diagnostic performance was observed when combining the results of MRI with those of [18F]FDG PET/CT, with an area under the ROC curve equal t
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- 2021
14. Role of Multimodal Imaging in Patients With Suspected Infections After the Bentall Procedure
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Sollini, M, Bartoli, F, Boni, R, Zanca, R, Colli, A, Levantino, M, Menichetti, F, Ferrari, M, Berchiolli, R, Lazzeri, E, Erba, P, Sollini M., Bartoli F., Boni R., Zanca R., Colli A., Levantino M., Menichetti F., Ferrari M., Berchiolli R., Lazzeri E., Erba P. A., Sollini, M, Bartoli, F, Boni, R, Zanca, R, Colli, A, Levantino, M, Menichetti, F, Ferrari, M, Berchiolli, R, Lazzeri, E, Erba, P, Sollini M., Bartoli F., Boni R., Zanca R., Colli A., Levantino M., Menichetti F., Ferrari M., Berchiolli R., Lazzeri E., and Erba P. A.
- Abstract
Purpose: This study aimed to assess the diagnostic performances of multimodal imaging [i.e., white blood cell single-photon emission computed tomography/CT (99m Tc-HMPAO-WBC SPECT/CT) and 18-fluoride-fluorodeoxyglucose positron emission tomography/CT ([18 F]FDG PET/CT)] in patients with suspected infection after the Bentall procedure, proposing new specific diagnostic criteria for the diagnosis. Methods: Between January 2009 and December 2019, we selected within a cardiovascular infections registry, 76 surgically treated patients (27 women and 49 men, median 66 years, and range 29–83 years). All the patients underwent molecular imaging for a suspected infection after the replacement of the aortic valve and ascending aorta according to the Bentall procedure. We analyzed 98 scans including 4999m Tc-WBC and 49 [18 F]FDG PET/CT. A total of 22 patients with very early/early suspected infection (<3 months after surgery) were imaged with both the techniques. Positive imaging was classified according to the anatomical site of increased uptake: to the aortic valve (AV), to both the AV and AV tube graft (AVTG) or to the TG, to surrounding tissue, and/or to extracardiac sites (embolic events or other sites of concomitant infection). Standard clinical workup included in all the patients having echocardiography/CT, blood culture, and the Duke criteria. Pretest probability and positive/negative likelihood ratio were calculated. Sensitivity and specificity of99m Tc labeled hexamethylpropylene amine oxime-WBC SPECT/CT (99m Tc-HMPAO-WBC SPECT/CT) and [18 F]FDG PET/CT imaging were calculated by using microbiology (n = 35) or clinical follow-up (n = 41) as final diagnosis.99m Tc-HMPAO-WBC scintigraphy and [18 F]FDG PET/CT findings were compared with 95% CIs by using the McNemar test to those of echocardiography/CT, blood culture, and the Duke criteria. Results: Sensitivity, specificity, and accuracy of99m Tc-HMPAO-WBC were 86, 92, and 88%, respectively, with a slightly higher sensi
- Published
- 2021
15. ESICM LIVES 2016: part three: Milan, Italy. 1–5 October 2016
- Author
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Velasquez, T., Mackey, G., Lusk, J., Kyle, U. G., Fontenot, T., Marshall, P., Shekerdemian, L. S., Coss-Bu, J. A., Nishigaki, A., Yatabe, T., Tamura, T., Yamashita, K., Yokoyama, M., Ruiz-Rodriguez, J. C., Encina, B., Belmonte, R., Troncoso, I., Tormos, P., Riveiro, M., Baena, J., Sanchez, A., Bañeras, J., Cordón, J., Duran, N., Ruiz, A., Caballero, J., Nuvials, X., Riera, J., Serra, J., Rutten, A. M. F., van Ieperen, S. N. M., Der Kinderen, E. P. H. M., Van Logten, T., Kovacikova, L., Skrak, P., Zahorec, M., Kyle, U. G., Akcan-Arikan, A., Silva, J. C., Mackey, G., Lusk, J., Goldsworthy, M., Shekerdemian, L. S., Coss-Bu, J. A., Wood, D., Harrison, D., Parslow, R., Davis, P., Pappachan, J., Goodwin, S., Ramnarayan, P., Chernyshuk, S., Yemets, H., Zhovnir, V., Pulitano’, S. M., De Rosa, S., Mancino, A., Villa, G., Tosi, F., Franchi, P., Conti, G., Patel, B., Khine, H., Shah, A., Sung, D., Singer, L., Haghbin, S., Inaloo, S., Serati, Z., Idei, M., Nomura, T., Yamamoto, N., Sakai, Y., Yoshida, T., Matsuda, Y., Yamaguchi, Y., Takaki, S., Yamaguchi, O., Goto, T., Longani, N., Medar, S., Abdel-Aal, I. R., El Adawy, A. S., Mohammed, H. M. E. H., Mohamed, A. N., Parry, S. M., Knight, L. D., Denehy, L., De Morton, N., Baldwin, C. E., Sani, D., Kayambu, G., da Silva, V. Z. M., Phongpagdi, P., Puthucheary, Z. A., Granger, C. L., Rydingsward, J. E., Horkan, C. M., Christopher, K. B., McWilliams, D., Jones, C., Reeves, E., Atkins, G., Snelson, C., Aitken, L. M., Rattray, J., Kenardy, J., Hull, A. M., Ullman, A., Le Brocque, R., Mitchell, M., Davis, C., Macfarlane, B., Azevedo, J. C., Rocha, L. L., De Freitas, F. F. M., Cavalheiro, A. M., Lucinio, N. M., Lobato, M. S., Ebeling, G., Kraegpoeth, A., Laerkner, E., De Brito-Ashurst, I., White, C., Gregory, S., Forni, L. G., Flowers, E., Curtis, A., Wood, C. A., Siu, K., Venkatesan, K., Muhammad, J. B. H., Ng, L., Seet, E., Baptista, N., Escoval, A., Tomas, E., Agrawal, R., Mathew, R., Varma, A., Dima, E., Charitidou, E., Perivolioti, E., Pratikaki, M., Vrettou, C., Giannopoulos, A., Zakynthinos, S., Routsi, C., Atchade, E., Houzé, S., Jean-Baptiste, S., Thabut, G., Genève, C., Tanaka, S., Lortat-Jacob, B., Augustin, P., Desmard, M., Montravers, P., de Molina, F. J. González, Barbadillo, S., Alejandro, R., Álvarez-Lerma, F., Vallés, J., Catalán, R. M., Palencia, E., Jareño, A., Granada, R. M., Ignacio, M. L., Cui, N., Liu, D., Wang, H., Su, L., Qiu, H., Li, R., Jaffal, K., Rouzé, A., Poissy, J., Sendid, B., Nseir, S., Paramythiotou, E., Rizos, M., Frantzeskaki, F., Antoniadou, A., Vourli, S., Zerva, L., Armaganidis, A., Riera, J., Gottlieb, J., Greer, M., Wiesner, O., Martínez, M., Acuña, M., Rello, J., Welte, T., Atchade, E., Mignot, T., Houzé, S., Jean-Baptiste, S., Thabut, G., Lortat-Jacob, B., Tanaka, S., Augustin, P., Desmard, M., Montravers, P., Soussi, S., Dudoignon, E., Ferry, A., Chaussard, M., Benyamina, M., Alanio, A., Touratier, S., Chaouat, M., Lafaurie, M., Mimoun, M., Mebazaa, A., Legrand, M., Sheils, M. A., Patel, C., Mohankumar, L., Akhtar, N., Noriega, S. K. Pacheco, Aldana, N. Navarrete, León, J. L. Ávila, Baquero, J. Durand, Bernal, F. Fernández, Ahmadnia, E., Hadley, J. S., Millar, M., Hall, D., Hewitt, H., Yasuda, H., Sanui, M., Komuro, T., Kawano, S., Andoh, K., Yamamoto, H., Noda, E., Hatakeyama, J., Saitou, N., Okamoto, H., Kobayashi, A., Takei, T., Matsukubo, S., Rotzel, H. B., Lázaro, A. Serrano, Prada, D. Aguillón, Gimillo, M. Rodriguez, Barinas, O. Diaz, Cortes, M. L. Blasco, Franco, J. Ferreres, Roca, J. M. Segura, Carratalá, A., Gonçalves, B., Turon, R., Mendes, A., Miranda, F., Mata, P. J., Cavalcanti, D., Melo, N., Lacerda, P., Kurtz, P., Righy, C., Rosario, L. E. de la Cruz, Lesmes, S. P. Gómez, Romero, J. C. García, Herrera, A. N. García, Pertuz, E. D. Díaz, Sánchez, M. J. Gómez, Sanz, E. Regidor, Hualde, J. Barado, Hernández, A. Ansotegui, Irazabal, J. M. Guergué, Spatenkova, V., Bradac, O., Suchomel, P., Urli, T., Lazzeri, E. Heusch, Aspide, R., Zanello, M., Perez-Borrero, L., Garcia-Alvarez, J. M., Arias-Verdu, M. D., Aguilar-Alonso, E., Rivera-Fernandez, R., Mora-Ordoñez, J., De La Fuente-Martos, C., Castillo-Lorente, E., Guerrero-Lopez, F., Lesmes, S. P. Gómez, Rosario, L. E. De la Cruz, Pertuz, E. D. Díaz, Hernández, A. Ansotegui, Romero, J. C. García, Sánchez, M. J. Gómez, Herrera, A. N. García, Ramírez, J. Roldán, Sanz, E. Regidor, Hualde, J. Barado, León, J. P. Tirapu, Navarro-Guillamón, L., Cordovilla-Guardia, S., Iglesias-Santiago, A., Guerrero-López, F., Fernández-Mondéjar, E., Vidal, A., Perez, M., Juez, A., Arias, N., Colino, L., Perez, J. L., Pérez, H., Calpe, P., Alcala, M. A., Robaglia, D., Perez, C., Lan, S. K., Cunha, M. M., Moreira, T., Santos, F., Lafuente, E., Fernandes, M. J., Silva, J. G., Rosario, L. E. de la Cruz, Lesmes, S. P. Gómez, Herrera, A. N. García, Romero, J. C. García, Pertuz, E. D. Díaz, Sánchez, M. J. Gómez, Sanz, E. Regidor, Echeverría, J. G. Armando, Hernández, A. Ansotegui, Hualde, J. Barado, Podlepich, V., Sokolova, E., Alexandrova, E., Lapteva, K., Kurtz, P., Shuinotsuka, C., Rabello, L., Vianna, G., Reis, A., Cairus, C., Salluh, J., Bozza, F., Torres, J. C. Barrios, Araujo, N. J. Fernández, García-Olivares, P., Keough, E., Dalorzo, M., Tang, L. K., De Sousa, I., Díaz, M., Marcos-Zambrano, L. J., Guerrero, J. E., Gomez, S. E. Zamora, Lopez, G. D. Hernandez, Cuellar, A. I. Vazquez, Nieto, O. R. Perez, Gonzalez, J. A. Castanon, Bhasin, D., Rai, S., Singh, H., Gupta, O., Bhattal, M. K., Sampley, S., Sekhri, K., Nandha, R., Aliaga, F. A., Olivares, F., Appiani, F., Farias, P., Alberto, F., Hernández, A., Pons, S., Sonneville, R., Bouadma, L., Neuville, M., Mariotte, E., Radjou, A., Lebut, J., Chemam, S., Voiriot, G., Dilly, M. P., Mourvillier, B., Dorent, R., Nataf, P., Wolff, M., Timsit, J. F., Ediboglu, O., Ataman, S., Ozkarakas, H., Kirakli, C., Vakalos, A., Avramidis, V., Obukhova, O., Kurmukov, I. A., Kashiya, S., Golovnya, E., Baikova, V. N., Ageeva, T., Haritydi, T., Kulaga, E. V., Rios-Toro, J. J., Perez-Borrero, L., Aguilar-Alonso, E., Arias-Verdu, M. D., Garcia-Alvarez, J. M., Lopez-Caler, C., De La Fuente-Martos, C., Rodriguez-Fernandez, S., Sanchez-Orézzoli, M. Gomez, Martin-Gallardo, F., Nikhilesh, J., Joshi, V., Villarreal, E., Ruiz, J., Gordon, M., Quinza, A., Gimenez, J., Piñol, M., Castellanos, A., Ramirez, P., Jeon, Y. D., Jeong, W. Y., Kim, M. H., Jeong, I. Y., Ahn, M. Y., Ahn, J. Y., Han, S. H., Choi, J. Y., Song, Y. G., Kim, J. M., Ku, N. S., Shah, H., Kellner, F., Rezai, F., Mistry, N., Yodice, P., Ovnanian, V., Fless, K., Handler, E., Alejos, R. Martínez, Romeu, J. D. Martí, Antón, D. González, Quinart, A., Martí, A. Torres, Llaurado-Serra, M., Lobo-Civico, A., Ventura-Rosado, A., Piñol-Tena, A., Pi-Guerrero, M., Paños-Espinosa, C., Peralvo-Bernat, M., Marine-Vidal, J., Gonzalez-Engroba, R., Montesinos-Cerro, N., Treso-Geira, M., Valeiras-Valero, A., Martinez-Reyes, L., Sandiumenge, A., Jimenez-Herrera, M. F., Helyar, S., Riozzi, P., Noon, A., Hallows, G., Cotton, H., Keep, J., Hopkins, P. A., Taggu, A., Renuka, S., Sampath, S., Rood, P. J. T., Frenzel, T., Verhage, R., Bonn, M., Pickkers, P., van der Hoeven, J. G., van den Boogaard, M., Corradi, F., Melnyk, L., Moggia, F., Pienovi, R., Adriano, G., Brusasco, C., Mariotti, L., Lattuada, M., Bloomer, M. J., Coombs, M., Ranse, K., Endacott, R., Maertens, B., Blot, K., Blot, S., Amerongen, M. P. van Nieuw, van der Heiden, E. S., Twisk, J. W. R., Girbes, A. R. J., Spijkstra, J. J., Riozzi, P., Helyar, S., Cotton, H., Hallows, G., Noon, A., Bell, C., Peters, K., Feehan, A., Keep, J., Hopkins, P. A., Churchill, K., Hawkins, K., Brook, R., Paver, N., Endacott, R., Maistry, N., van Wijk, A., Rouw, N., van Galen, T., Evelein-Brugman, S., Taggu, A., Krishna, B., Sampath, S., Putzu, A., Fang, M., Berto, M. Boscolo, Belletti, A., Cassina, T., Cabrini, L., Mistry, M., Alhamdi, Y., Welters, I., Abrams, S. T., Toh, C. H., Han, H. S., Gil, E. M., Lee, D. S., Park, C. M., Winder-Rhodes, S., Lotay, R., Doyle, J., Ke, M. W., Huang, W. C., Chiang, C. H., Hung, W. T., Cheng, C. C., Lin, K. C., Lin, S. C., Chiou, K. R., Wann, S. R., Shu, C. W., Kang, P. L., Mar, G. Y., Liu, C. P., Dubó, S., Aquevedo, A., Jibaja, M., Berrutti, D., Labra, C., Lagos, R., García, M. F., Ramirez, V., Tobar, M., Picoita, F., Peláez, C., Carpio, D., Alegría, L., Hidalgo, C., Godoy, K., Bakker, J., Hernández, G., Sadamoto, Y., Katabami, K., Wada, T., Ono, Y., Maekawa, K., Hayakawa, M., Sawamura, A., Gando, S., Marin-Mateos, H., Perez-Vela, J. L., Garcia-Gigorro, R., Peiretti, M. A. Corres, Lopez-Gude, M. J., Chacon-Alves, S., Renes-Carreño, E., Montejo-González, J. C., Parlevliet, K. L., Touw, H. R. W., Beerepoot, M., Boer, C., Elbers, P. W. G., Tuinman, P. R., Abdelmonem, S. A., Helmy, T. A., El Sayed, I., Ghazal, S., Akhlagh, S. H., Masjedi, M., Hozhabri, K., Kamali, E., Zýková, I., Paldusová, B., Sedlák, P., Morman, D., Youn, A. M., Ohta, Y., Sakuma, M., Bates, D., Morimoto, T., Su, P. L., Chang, W. Y., Lin, W. C., Chen, C. W., Facchin, F., Zarantonello, F., Panciera, G., De Cassai, A., Venrdramin, A., Ballin, A., Tonetti, T., Persona, P., Ori, C., Del Sorbo, L., Rossi, S., Vergani, G., Cressoni, M., Chiumello, D., Chiurazzi, C., Brioni, M., Algieri, I., Tonetti, T., Guanziroli, M., Colombo, A., Tomic, I., Colombo, A., Crimella, F., Carlesso, E., Gasparovic, V., Gattinoni, L., Neto, A. Serpa, Schmidt, M., Pham, T., Combes, A., de Abreu, M. Gama, Pelosi, P., Schultz, M. J., Katira, B. H., Engelberts, D., Giesinger, R. 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Iglesias, Sáez, V. Chica, Ruiz-Ruano, R. de la Chica, González, A. Sánchez, Kunze-Szikszay, N., Wand, S., Klapsing, P., Wetz, A., Heyne, T., Schwerdtfeger, K., Troeltzsch, M., Bauer, M., Quintel, M., Moerer, O., Cook, D. J., Rutherford, W. B., Scales, D. C., Adhikari, N. K., Cuthbertson, B. H., Suzuki, T., Takei, T., Fushimi, K., Iwamoto, M., Nakagawa, S., Mendsaikhan, N., Begzjav, T., Lundeg, G., Dünser, M. W., Romero, D. González, Cabrera, J. L. Santana, Santana, J. D. Martín, Padilla, Y. Santana, Pérez, H. Rodríguez, Torrent, R. Lorenzo, Kleinpell, R., Chouris, I., Radu, V., Stougianni, M., Lavrentieva, A., Lagonidis, D., Price, R. D. T., Day, A., Arora, N., Henderson, M. A., Hickey, S., Costa, M. I. Almeida, Carvalho, J. P., Gomes, A. A., Mergulhão, P. J., Chan, K. K. C., Shum, H. P., Yan, W. W., Maghsoudi, B., Tabei, S. H., Masjedi, M., Sabetian, G., Tabatabaei, H. R., Akbarzadeh, A., Saigal, S., Pakhare, A., Joshi, R., Pattnaik, S. K., Ray, B., Rousseau, A. F., Michel, L., Bawin, M., Cavalier, E., Reginster, J. Y., Damas, P., Bruyere, O., Zhou, J. C., Cauwenberghs, H., De Backer, A., Neels, H., Deblier, I., Berghmans, J., Himpe, D., Barea-Mendoza, J. A., Portillo, I. Prieto, Fernández, M. Valiente, Gigorro, R. Garcia, Vela, J. L. Perez, Mateos, H. Marín, Alves, S. Chacón, Varas, G. Morales, Rodriguez-Biendicho, A., Carreño, E. Renes, González, J. C. Montejo, Yang, J. S., Chiang, C. H., Hung, W. T., Huang, W. C., Cheng, C. C., Lin, K. C., Lin, S. C., Chiou, K. R., Wann, S. R., Lin, K. L., Kang, P. L., Mar, G. Y., Liu, C. P., Zhou, J. C., Choi, Y. J., Yoon, S. Z., Gordillo-Brenes, A., Fernandez-Zamora, M. D., Perez-Borrero, L., Arias-Verdu, M. D., Aguilar-Alonso, E., Herruzo-Aviles, A., Garcia-Delgado, M., Hinojosa-Perez, R., Curiel-Balsera, E., Rivera-Fernandez, R., Lesmes, S. P. Gómez, Rosario, L. E. De la Cruz, Hernández, A. Ansotegui, Herrera, A. N. García, Sanz, E. Regidor, Sánchez, M. J. Gómez, Hualde, J. Barado, Pascual, O. Agudo, León, J. P. Tirapu, Irazabal, J. M. Guergue, Pérez, A. González, Fernández, P. Alvarez, Amor, L. Lopéz, Albaiceta, G. Muñiz, Lesmes, S. P. Gómez, Rosario, L. E. De la Cruz, Hernández, A. Ansotegui, Sanz, E. Regidor, Sánchez, M. J. Gómez, Calvo, S. Aldunate, Herrera, A. N. García, Hualde, J. Barado, Pascual, O. Agudo, León, J. P. Tirapu, Corona, A., Ruffini, C., Spazzadeschi, A., Marrazzo, F., Gandola, A., Sciurti, R., Savi, C., Catena, E., Ke, M. W., Cheng, C. C., Huang, W. C., Chiang, C. H., Hung, W. T., Lin, K. C., Lin, S. C., Wann, S. R., Chiou, K. R., Tseng, C. J., Kang, P. L., Mar, G. Y., Liu, C. P., Bertini, P., De Sanctis, F., Guarracino, F., Bertini, P., Baldassarri, R., Guarracino, F., Buitinck, S. H., van der Voort, P. H. J., Oto, J., Nakataki, E., Tsunano, Y., Izawa, M., Tane, N., Onodera, M., Nishimura, M., Ghosh, S., Gupta, A., De Gasperi, A., Mazza, E., Limuti, R., Prosperi, M., Bissenova, N., Yergaliyeva, A., Talan, L., Yılmaz, G., Güven, G., Yoruk, F., Altıntas, N. D., Mukherjee, D. N., Agarwal, L. K., Mandal, K., Palomar, M., Balsera, B., Vallverdu, M., Martinez, M., Garcia, M., Castellana, D., Lopez, R., Barcenilla, F., Kaminsky, G. E., Carreño, R., Escribá, A., Fuentes, M., Gálvez, V., Del Olmo, R., Nieto, B., Vaquerizo, C., Alvarez, J., De la Torre, M. A., Torres, E., Bogossian, E., Nouer, S. Aranha, Salgado, D. Ribeiro, Brugger, S. Carvalho, Jiménez, G. Jiménez, Torner, M. Miralbés, Vidal, M. Vallverdú, Garrido, B. Balsera, Casals, X. Nuvials, Gaite, F. Barcenilla, Cabello, J. Trujillano, Martínez, M. Palomar, Doganci, M., Izdes, S., Besevli, S. Guzeldag, Alkan, A., Kayaaslan, B., Ramírez, C. Sánchez, Balcázar, L. Caipe, Santana, M. Cabrera, Viera, M. A. Hernández, Escalada, S. Hípola, Vázquez, C. F. Lübbe, Penichet, S. M. Marrero, Campelo, F. Artiles, López, M. A. De La Cal, Santana, P. Saavedra, Santana, S. Ruíz, Repessé, X., Artiguenave, M., Paktoris-Papine, S., Espinasse, F., Dinh, A., El Sayed, F., Charron, C., Géri, G., Vieillard-Baron, A., Marmanidou, K., Oikonomou, M., Nouris, C., Dimitroulakis, K., Soilemezi, E., Matamis, D., Ferré, A., Guillot, M., Teboul, J. L., Lichtenstein, D., Mézière, G., Richard, C., Monnet, X., Pham, T., Beduneau, G., Schortgen, F., Piquilloud, L., Zogheib, E., Jonas, M., Grelon, F., Runge, I., Terzi, N., Grangé, S., Barberet, G., Guitard, P. G., Frat, J. P., Constan, A., Chrétien, J. M., Mancebo, J., Mercat, A., Richard, J. C. M., Brochard, L., Prīdāne, S., Sabeļņikovs, O., Mojoli, F., Orlando, A., Bianchi, I., Torriglia, F., Bianzina, S., Pozzi, M., Iotti, G. A., Braschi, A., Beduneau, G., Pham, T., Schortgen, F., Piquilloud, L., Zogheib, E., Jonas, M., Grelon, F., Runge, I., Terzi, N., Grangé, S., Barberet, G., Guitard, P. G., Frat, J. P., Constan, A., Chrétien, J. M., Mancebo, J., Mercat, A., Richard, J. C. M., Brochard, L., Kondili, E., Psarologakis, C., Kokkini, S., Amargianitakis, V., Babalis, D., Chytas, A., Chouvarda, I., Vaporidi, K., Georgopoulos, D., Trapp, O., Kalenka, A., Mojoli, F., Orlando, A., Bianchi, I., Torriglia, F., Bianzina, S., Pozzi, M., Iotti, G. A., Braschi, A., Lozano, J. A. Benítez, Sánchez, P. Carmona, Francioni, J. E. Barrueco, Ferrón, F. Ruiz, Simón, J. M. Serrano, Spadaro, S., Karbing, D. S., Gioia, A., Moro, F., Corte, F. Dalla, Mauri, T., Volta, C. A., Rees, S. E., Petrova, M. V., Mohan, R., Butrov, A. V., Beeharry, S. D., Vatsik, M. V., Sakieva, F. I., Gobert, F., Yonis, H., Tapponnier, R., Fernandez, R., Labaune, M. A., Burle, J. F., Barbier, J., Vincent, B., Cleyet, M., Richard, J. C., Guérin, C., Shinotsuka, C. Righy, Creteur, J., Taccone, F. S., Törnblom, S., Nisula, S., Vaara, S., Poukkanen, M., Andersson, S., Pettilä, V., Pesonen, E., Xie, Z., Liao, X., Kang, Y., Zhang, J., Kubota, K., Egi, M., Mizobuchi, S., Hegazy, S., El-Keraie, A., El Sayed, E., El Hamid, M. Abd, Rodrigues, N. J., Pereira, M., Godinho, I., Gameiro, J., Neves, M., Gouveia, J., e Silva, Z. Costa, Lopes, J. A., Mckinlay, J., Kostalas, M., Kooner, G., Dudas, G., Horton, A., Kerr, C., Karanjia, N., Creagh-Brown, B., Forni, L., Yamazaki, A., Ganuza, M. Sanz, Molina, J. A. Martinez, Martinez, F. Hidalgo, Freile, M. T. Chiquito, Fernandez, N. Garcia, Travieso, P. Medrano, Bandert, A., Frithiof, R., Lipcsey, M., Smekal, D., Schlaepfer, P., Durovray, J. D., Plouhinec, V., Chiappa, C., Bellomo, R., Schneider, A. G., Mitchell, S., Durrant, J., Street, H., Dunthorne, E., Shears, J., Caballero, C. Hernandez, Hutchison, R., Schwarze, S., Ghabina, S., Thompson, E., Prowle, J. R., Kirwan, C. J., Gonzalez, C. A., Pinto, J. L., Orozco, V., Patiño, J. A., Garcia, P. K., Contreras, K. M., Rodriguez, P., Echeverri, J. E., GETGAG Working Group, JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group, CAPCRI Study, for the ReVA Research Network and the PROVE Network Investigators, from the FROG ICU Investigators, The WIND study group, Plug Working Group, GETGAG/SEMICYUC, AKI Research Group, St George’s University of London, IPREA Study Group, FINNRESUSCI Study Group, PICS- HCPA: Programa Intrahospitalar de Combate à Sepse do Hospital de Clínicas de Porto Alegre, ENVIN-HELICS Study Group, ARIAM registry of adult cardiac surgery, The Rapid Diagnosis of Infections in the Critically Ill Team, Tokyo Womens Medical University, PLUG working group, PLUG Working Group, On behalf of Okayama Research Investigation Organizing Network (ORION)investigators, PS-ICU Group, Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group, Student Research Committee - Shiraz University of Medical Sciences, ARIAM-ANDALUCIA, The WIND study group, PLUG Working Group, The WIND study group, PLUG Working Group, and Plug working group
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- 2016
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16. On the optimization of Software Obfuscation against Hardware Trojans in Microprocessors
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Cassano, L, Lazzeri, E, Litovchenko, N, and Di Natale, G
- Subjects
Genetic Algorithm ,Software Obfuscation ,Hardware Trojan Horses ,Hardware Security ,Microprocessors - Published
- 2022
17. InfraScience research activity report 2021
- Author
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Artini M., Assante M., Atzori C., Baglioni M., Bardi A., Bove P., Candela L., Casini G., Castelli D., Cirillo R., Coro G., De Bonis M., Debole F., Dell'Amico A., Frosini L., La Bruzzo S., Lazzeri E., Lelii L., Manghi P., Mangiacrapa F., Mangione D., Mannocci A., Ottonello E., Pagano P., Panichi G., Pavone G., Piccioli T., Sinibaldi F., and Straccia U.
- Subjects
Infrastructure ,Open Sciece ,Intelligent Systems - Abstract
InfraScience is a research group of the National Research Council of Italy - Institute of Information Science and Technologies (CNR - ISTI) based in Pisa, Italy. This report documents the research activity performed by this group in 2021 to highlight the major results. In particular, the InfraScience group confronted with research challenges characterising Data Infrastructures, eScience, and Intelligent Systems. The group activity is pursued by closely connecting research and development and by promoting and supporting open science. In fact, the group is leading the development of two large scale infrastructures for Open Science, i.e. D4Science and OpenAIRE. During 2021 InfraScience members contributed to the publishing of 25 papers, to the research and development activities of 18 research projects (15 funded by EU), to the organization of conferences and training events, to several working groups and task forces.
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- 2022
18. Pharmacokinetic Evaluation of Two Monoclonal Antibodies as Possible Immunoscintigraphy Agents for Pancreatic Cancer in Humans
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Molea, N., Bodei, L., Lazzeri, E., Bacciardi, D., Giulianotti, P. C., Balestracci, D., Viacava, P., Campani, D., Di Luca, L., Salvadori, P. A., Bonino, C., Gold, D. V., Sharkey, R. M., Goldenberg, D. M., Mosca, F., Mariani, G., Bergmann, H., editor, Kroiss, A., editor, and Sinzinger, H., editor
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- 1997
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19. Biodistribution Pharmacokinetics and Dosimetry of 99m Tc-D-Glucaric Acid in Humans
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Molea, N., Lazzeri, E., Bodei, L., DiLuca, L., Bacciardi, D., Khaw, B. A., Pak, K. Y., Narula, J., Strauss, H. W., Bianchi, R., Mariani, G., Bergmann, H., editor, Kroiss, A., editor, and Sinzinger, H., editor
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- 1997
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20. POS-067 TUBULAR CELL POLYPLOIDY IS LIFESAVING AFTER ACUTE KIDNEY INJURY AND A TARGET TO PREVENT CHRONIC KIDNEY DISEASE
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De Chiara, L., primary, Lazzeri, E., additional, and Romagnani, P., additional
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- 2022
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21. Radiolabelled leucocyte scintigraphy versus conventional radiological imaging for the management of late, low-grade vascular prosthesis infections
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Erba, P. A., Leo, G., Sollini, M., Tascini, C., Boni, R., Berchiolli, R. N., Menichetti, F., Ferrari, M., Lazzeri, E., and Mariani, G.
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- 2014
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22. [18F]FDG hypermetabolisms of the spleen and/or bone marrow: indirect signs of bacteremia
- Author
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Zanca, R, primary, Bartoli, F, additional, Lazzeri, E, additional, Sollini, M, additional, Slart, RHJA, additional, and Erba, PA, additional
- Published
- 2021
- Full Text
- View/download PDF
23. Progettare un evento divulgativo online. L'esperienza di 'Fai una domanda su Covid-19, gli esperti rispondono'
- Author
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Pavone G., Lazzeri E., Circella M., and De Leo F.
- Subjects
SARS-CoV-2 ,Divulgazione scientifica ,Covid-19 - Abstract
Il documento raccoglie le domande ricevute e le risposte date in occasione del webinar "Fai una domanda su Covid-19, gli esperti rispondono", realizzato il 27 novembre 2020. Inoltre il report descrive gli aspetti principali dell'organizzazione di un webinar "Ask Me Anything", che voleva essere un evento informativo, online e rivolto ai giovani sul tema pandemia di Covid-19. A distanza di diversi mesi dall'inizio della pandemia, erano ancora tanti i dubbi e le incertezze diffuse tra le persone, anche riguardo ad aspetti noti e chiariti in sede di ricerca scientifica. In occasione dell'edizione 2020 della Notte Europea dei Ricercatori e delle Ricercatrici, e? stato fatto uno sforzo divulgativo di apertura e confronto con alcuni esperti impegnati nella ricerca su Sars-Cov-2 e Covid- 19.
- Published
- 2021
24. InfraScience Research Activity Report 2020
- Author
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Artini M., Assante M., Atzori C., Baglioni M., Bardi A., Candela L., Casini G., Castelli D., Cirillo R., Coro G., Debole F., Dell'Amico A., Frosini L., La Bruzzo S., Lazzeri E., Lelii L., Manghi P., Mangiacrapa F., Mannocci A., Pagano P., Panichi G., Piccioli T., Sinibaldi F., and Straccia U.
- Subjects
Infrastructure ,Open Science ,Intelligent systems ,Activity report ,Research report - Abstract
InfraScience is a research group of the National Research Council of Italy - Institute of Information Science and Technologies (CNR - ISTI) based in Pisa, Italy. This report documents the research activity performed by this group in 2020 to highlight the major results. In particular, the InfraScience group confronted with research challenges characterising Data Infrastructures, e\-Sci\-ence, and Intelligent Systems. The group activity is pursued by closely connecting research and development and by promoting and supporting open science. In fact, the group is leading the development of two large scale infrastructures for Open Science, \ie D4Science and OpenAIRE. During 2020 InfraScience members contributed to the publishing of 30 papers, to the research and development activities of 12 research projects (11 funded by EU), to the organization of conferences and training events, to several working groups and task forces.
- Published
- 2021
25. Infective Endocarditis and Cardiovascular Implantable Electronic Device Infection
- Author
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Lazzeri, E, Signore, A, Erba, PA, Prandini, N, Versari, A, D ́Errico, G, Mariani, G, Sollini, M, Bandera, F, Bartoli, F, Zanca, R, Erba, P, Sollini, Martina, Bandera, Francesco, Bartoli, Francesco, Zanca, Roberta, Lazzeri, Elena, Erba, Paola Anna, Lazzeri, E, Signore, A, Erba, PA, Prandini, N, Versari, A, D ́Errico, G, Mariani, G, Sollini, M, Bandera, F, Bartoli, F, Zanca, R, Erba, P, Sollini, Martina, Bandera, Francesco, Bartoli, Francesco, Zanca, Roberta, Lazzeri, Elena, and Erba, Paola Anna
- Abstract
Cardiovascular infections are associated with high morbidity and mortality. Early diagnosis is crucial for adequate patient’s management, as early treatment improves the prognosis. Cardiovascular infections are difficult to diagnose on the basis of a single symptom, sign, or diagnostic test. Rather, the diagnosis requires a multidisciplinary discussion in addition to the integration of clinical signs, microbiology data, and imaging data. The application of multimodality imaging, including molecular imaging techniques, has improved the sensitivity to detect infections involving heart valves and vessels and implanted cardiovascular devices, while also allowing for early detection of septic emboli and metastatic infections before these become clinically apparent. This chapter describes the main epidemiological, clinical, and diagnostic challenges in infective endocarditis and infections associated with cardiovascular implantable electronic devices, with particular regard to the role of WBC SPECT/CT and [18F]FDG PET/CT in each diagnostic algorithm. In addition, the needs of proper hybrid equipment, dedicated imaging acquisition protocols, specific expertise for imaging reading and imaging interpretations in this field are discussed, emphasizing the need of a specific reference framework within a cardiovascular multidisciplinary team approach.
- Published
- 2021
26. Nuclear Medicine Imaging of Non-orthopedic or Cardiovascular Implantable Device Infection
- Author
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Lazzeri, E, Signore, A, Erba, PA, Prandini, N, Versari, A, D ́Errico, G, Mariani, G, Erba, P, Bartoli, F, Zanca, R, Sollini, M, Erba, Paola Anna, Bartoli, Francesco, Zanca, Roberta, Sollini, Martina, Lazzeri, E, Signore, A, Erba, PA, Prandini, N, Versari, A, D ́Errico, G, Mariani, G, Erba, P, Bartoli, F, Zanca, R, Sollini, M, Erba, Paola Anna, Bartoli, Francesco, Zanca, Roberta, and Sollini, Martina
- Abstract
The use of implantable medical devices has increased in “modern” medical and surgical practice, and the rate of their infections is variable, depending on the type of device and the population risk profile. The overall risk of device-related infection across the population is around 1%, but it might be significantly increased in specific populations as vulnerability to microbial pathogens increases in elderly, immuno-compromised, and hospitalized patients. Device-related infection results from the multifaceted interaction of bacterial, device, and host factor. Multiresistant nosocomial pathogens are the most common organisms colonizing the surface of devices, and a full understanding of how a biofilm formation is crucial to understand the pathogenesis of their infection and define the most suitable treatment. This chapter describes the most relevant implantable medical devices of interest to nuclear medicine and the corresponding diagnostic strategy for each of them with particular regard to the role of nuclear medicine procedure in the diagnostic algorithm.
- Published
- 2021
27. The critical role of SDF-1/CXCR4 axis in cancer and cancer stem cells metastasis
- Author
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Gelmini, S., Mangoni, M., Serio, M., Romagnani, P., and Lazzeri, E.
- Published
- 2008
- Full Text
- View/download PDF
28. Can we produce an image of bacteria with radiopharmaceuticals?
- Author
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Signore, A., D’Alessandria, C., Lazzeri, E., and Dierckx, R.
- Published
- 2008
- Full Text
- View/download PDF
29. Comprehensive meta-analysis on [18F] FDG PET/CT and radiolabelled leukocyte SPECT–SPECT/CT imaging in infectious endocarditis and cardiovascular implantable electronic device infections
- Author
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Cantoni, V, Sollini, M, Green, R, Berchiolli, R, Lazzeri, E, Mannarino, T, Acampa, W, Erba, P, Cantoni V., Sollini M., Green R., Berchiolli R., Lazzeri E., Mannarino T., Acampa W., Erba P. A., Cantoni, V, Sollini, M, Green, R, Berchiolli, R, Lazzeri, E, Mannarino, T, Acampa, W, Erba, P, Cantoni V., Sollini M., Green R., Berchiolli R., Lazzeri E., Mannarino T., Acampa W., and Erba P. A.
- Abstract
Background: The use of medical imaging has significantly increased over the past decade in all fields of medicine according to the advances in imaging technology. Cardiac infection represents an emblematic example where the use of nuclear molecular techniques is evolving as an important supplementary method for patients with suspected infection and diagnostic difficulties. Positron emission computed tomography (PET/CT) using fluor-18-fluorodeoxyglucose ([18F]FDG) and single-photon emission computed tomography (SPECT) using radiolabeled leukocyte (WBC) have been widely used in the diagnosis of infections. The aim of the present work is to provide a systematic review and meta-analysis of the published data on the use of hybrid nuclear medicine imaging [18F]FDG PET/CT and radiolabeled leukocyte SPECT in the diagnostic workup of patients with IE and CIED infection. Materials and methods: An English literature search was performed using the PubMed, Cochrane and Web of Science databases to identify articles. Studies were included if they assessed the diagnostic accuracy of [18F]FDG PET/CT and SPECT or SPECT/CT WBC in the diagnosis of possible infection, provided detailed criteria of a reference standard for diagnosis of infection, and provided sufficient data to determine sensitivity and specificity of [18F]FDG PET/CT and WBC SPECT–SPECT/CT. A first analysis was performed considering IE as endpoint and compared [18F]FDG PET/CT and WBC SPECT–SPECT/CT imaging. A second analysis considered CIED as endpoint was performed only on [18F]FDG PET imaging without a comparison with SPECT–SPECT/CT. Two additional analysis were performed, including (i) the sub-analysis of the manuscripts dealing with IE that were evaluated considering separately the ones dealing with NVE and PVE, (ii) the sub-analysis of the manuscripts for IE and CIED where patients underwent a specific preparation before undergoing [18F]FDG PET/CT scan. Results: The IE group included 14 [18F]FDG PET/CT and 3 SPECT/C
- Published
- 2018
30. The “3M” Approach to Cardiovascular Infections: Multimodality, Multitracers, and Multidisciplinary
- Author
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Sollini, M, Berchiolli, R, Delgado Bolton, R, Rossi, A, Kirienko, M, Boni, R, Lazzeri, E, Slart, R, Erba, P, Sollini M., Berchiolli R., Delgado Bolton R. C., Rossi A., Kirienko M., Boni R., Lazzeri E., Slart R., Erba P. A., Sollini, M, Berchiolli, R, Delgado Bolton, R, Rossi, A, Kirienko, M, Boni, R, Lazzeri, E, Slart, R, Erba, P, Sollini M., Berchiolli R., Delgado Bolton R. C., Rossi A., Kirienko M., Boni R., Lazzeri E., Slart R., and Erba P. A.
- Abstract
Cardiovascular infections are associated with high morbidity and mortality. Early diagnosis is crucial for adequate patient management, as early treatment improves the prognosis. The diagnosis cannot be made on the basis of a single symptom, sign, or diagnostic test. Rather, the diagnosis requires a multidisciplinary discussion in addition to the integration of clinical signs, microbiology data, and imaging data. The application of multimodality imaging, including molecular imaging techniques, has improved the sensitivity to detect infections involving heart valves and vessels and implanted cardiovascular devices while also allowing for early detection of septic emboli and metastatic infections before these become clinically apparent. In this review, we describe data supporting the use of a Multimodality, Multitracer, and Multidisciplinary approach (the 3M approach) to cardiovascular infections. In particular, the role of white blood cell SPECT/CT and [18F]FDG PET/CT in most prevalent and clinically relevant cardiovascular infections will be discussed. In addition, the needs of advanced hybrid equipment, dedicated imaging acquisition protocols, specific expertise for image reading, and interpretation in this field are discussed, emphasizing the need for a specific reference framework within a Cardiovascular Multidisciplinary Team Approach to select the best test or combination of tests for each specific clinical situation.
- Published
- 2018
31. Current status of molecular imaging in infections
- Author
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Sollini, M, Lauri, C, Boni, R, Lazzeri, E, Erba, P, Signore, A, Sollini M., Lauri C., Boni R., Lazzeri E., Erba P. A., Signore A., Sollini, M, Lauri, C, Boni, R, Lazzeri, E, Erba, P, Signore, A, Sollini M., Lauri C., Boni R., Lazzeri E., Erba P. A., and Signore A.
- Abstract
There is an increased need to find non-invasive tools for early diagnosis and follow-up of infections. Nuclear medicine techniques may be used to diagnose, localize and evaluate the severity and the extent of infections before the occurrence of anatomical abnormalities. This review focuses on different approaches based on radiolabelled cells, peptides and antibodies or [ 18 F]FDG to image infective diseases in agreement with what is being jointly evaluated by the European Association of Nuclear Medicine (EANM). This is particularly relevant, since the EANM has strated a wide program of collaboration with other European clinical societies to define common diagnostic flow-charts in many of these infective diseases. It emerges the role of radiolabelled WBC by SPECT/CT for prosthetic joint infections and of FDG by PET/CT for spondylodiscitis. Comparable values of accuracy have been described for WBC and FDG in the diagnosis of vascular fgraft infections, diabetic gfoot, endocarditis and peripheral bone osteomyelitis, with some exceptions.
- Published
- 2018
32. Acute kidney injury promotes development of papillary renal cell adenoma and carcinoma from renal progenitor cells
- Author
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Antonelli, G, Angelotti, Ml, Allinovi, M, Guzzi, F, Sisti, A, Semeraro, R, Conte, C, Mazzinghi, B, Nardi, S, Melica, Me, De Chiara, L, Lazzeri, E, Lasagni, L, Lottini, T, Landini, S, Giglio, S, Mari, A, Di Maida, F, Antonelli, A, Porpiglia, F, Schiavina, R, Ficarra, V, Facchiano, D, Gacci, M, Serni, S, Carini, M, Netto, Gj, Roperto, Rm, Magi, A, Christiansen, Cf, Rotondi, M, Liapis, H, Anders, Hj, Minervini, A, Raspollini, Mr, and Romagnani, P.
- Subjects
Acute kidney injury, renal cell carcinoma, renal progenitors - Published
- 2020
33. Event series: Open Science and Covid-19. Working together to fight the pandemic
- Author
-
De Leo F., Lazzeri E., Le Pera L., Pavone G., and Via A.
- Subjects
Coronavirus Disease Research Community - COVID-19 Open Science in Italy - Abstract
L'emergenza sanitaria da Covid-19 ha reso evidente la necessità di collaborare a livello globale. Per trovare soluzioni rapide ed efficaci alla pandemia è doveroso condividere nel modo più aperto possibile dati, pubblicazioni, software e altre tipologie di risultati scientifici. Se ne parlerà in una serie di webinar e tutorial organizzati dai nodi italiani di OpenAIRE, ELIXIR, RDA e EOSC Pillar.
- Published
- 2020
34. Open Science: come dare accesso aperto alla conoscenza, un focus sulle scienze della Terra e dell'ambiente
- Author
-
Lazzeri E., Pavone G., and Giamberini M.
- Subjects
Open Access ,Open Science ,Open Data ,Environmental Science ,Earth Science ,Research Data ,FAIR - Abstract
Presentation given during the event "Open Science: come dare accesso aperto alla conoscenza, un focus sulle scienze della Terra e dell'ambiente", organised by CNR and OpenAIRE, held on May 14th 2020. The record also contains questions collected during the event and related answers. The seminar intended to give basics about Open Science, Open Access, and FAIR data management in the field of Earth and environmental sciences. Outline of the event: Motivation behind Open Science Open Access to scientific literature Research data management (legal aspects, FAIR and Open data) Open Science and European Infrastructures for Earth and environmental sciences. More information: Page of the event on CNR website: https://www.cnr.it/it/evento/16797 Event page on OpenAIRE portal: https://www.openaire.eu/item/accesso-aperto-nelle-scienze-della-terra-e-dell-ambiente?category_id=528
- Published
- 2020
35. Nuclear Medicine Imaging of Cardiovascular Implantable Electronic Device Infection and Endocarditis
- Author
-
Signore, A, Glaudemans, AWJM, Erba, P, Sollini, M, Zanca, R, Marciano, A, Vitali, S, Bartoli, F, Lazzeri, E, Erba, PA, Signore, A, Glaudemans, AWJM, Erba, P, Sollini, M, Zanca, R, Marciano, A, Vitali, S, Bartoli, F, Lazzeri, E, and Erba, PA
- Abstract
Cardiovascular infections are associated with high morbidity and mortality. Early diagnosis is crucial for adequate patient management, as early treatment improves the prognosis, hardly diagnosed on the basis of a single symptom, sign or diagnostic test. Rather, the diagnosis requires a multidisciplinary discussion in addition to the integration of clinical signs, microbiology data and imaging data. The application of multimodality imaging, including molecular imaging techniques, has improved the sensitivity to detect infections involving heart valves and vessels and implanted cardiovascular devices while also allowing for early detection of septic emboli and metastatic infections before these become clinically apparent. In this chapter, we describe data supporting the use of a multimodality and multidisciplinary approach to cardiovascular infections. In particular, the role of WBC SPECT/CT and [18F]FDG PET/CT in most prevalent and clinically relevant cardiovascular infections is discussed.
- Published
- 2020
36. CXCR3 and (alpha sub E beta sub 7) integrin identify a subset of CD8+ mature thymocytes that share phenotypic and functional properties with CD8+ gut intraepithelial lymphocytes
- Author
-
Annunziato, F., Cosmi, L., Liotta, F., Lazzeri, E., Ramagnani, P., Angeli, R., Lasagni, L., Manetti, R., Marra, F., Gerard, C., Petrai, I., Dello Sbarba, P., Tonelli, F., Maggi, E., and Romagnani, S.
- Subjects
CD8 lymphocytes -- Research ,Integrins -- Research ,Gastrointestinal mucosa -- Physiological aspects ,Gastrointestinal mucosa -- Research ,Health - Published
- 2006
37. Role for interferon-γ inducible chemokines in endocrine autoimmunity: An expanding field
- Author
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Rotondi, M., Lazzeri, E., Romagnani, P., and Serio, Mario
- Published
- 2003
- Full Text
- View/download PDF
38. Produzione e verifiche di qualità dei radiofarmaci estemporanei da materiale autologo
- Author
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Lazzeri, E., primary, Viglietti, A. L., additional, De Palma, D., additional, and Maioli, C., additional
- Published
- 2011
- Full Text
- View/download PDF
39. Miniaturized radiochemical purity testing for 99mTc-HMPAO, 99mTc-HMDP, and 99mTc-tetrofosmin
- Author
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de la Fuente, A, Zanca, R, Boni, R, Cataldi, A, Sollini, M, Lazzeri, E, Mariani, G, Erba, P, de la Fuente A., Zanca R., Boni R., Cataldi A. G., Sollini M., Lazzeri E., Mariani G., Erba P. A., de la Fuente, A, Zanca, R, Boni, R, Cataldi, A, Sollini, M, Lazzeri, E, Mariani, G, Erba, P, de la Fuente A., Zanca R., Boni R., Cataldi A. G., Sollini M., Lazzeri E., Mariani G., and Erba P. A.
- Abstract
Quick methods are functional in clinical practice to ensure the fastest availability of radiopharmaceuticals. For this purpose, we investigated the radiochemical purity of the widely used 99mTc-hydroxymethylene diphosphonate, 99mTc-hexamethylpropyleneamine oxime, and 99mTc-tetrofosmin by reducing time as compared with the manufacturer's method. Methods: We applied a miniaturized chromatographic method with a reduced strip development from 18 cm to 9 cm for all 3 radiopharmaceuticals. The specific support medium and solvent system of the manufacturer's methods was kept unchanged for 99mTc-hydroxymethylene diphosphonate and 99mTc-tetrofosmin, whereas for 99mTc-hexamethylpropyleneamine oxime the instant thin-layer chromatography (ITLC) polysilicic gel (silicic acid [SA]) was replaced with a monosilicic gel (silicic gel [SG]) in the chromatographic system that uses methyl ethyl ketone as solvent. The method was applied and compared with the routine ITLC insert method in a total of 30 batches for each radiopharmaceutical. The precision of repeated tests was determined by comparison with the results of 10 replications on the same batch. Small volumes of concentrated 99mTcO4 -, and 99mTc-albumin nanocolloid were used to produce potential radiochemical impurities. Correlation between the quick methods and the insert methods was analyzed using a nonparametric 2-tailed test and a 2 · 2 contingency table with the associated Fisher exact test to evaluate sensitivity and specificity. A receiver-operating-characteristic analysis was performed to evaluate the best cutoff. Results: The percentage radiochemical purity of the quick methods agreed with the standard chromatography procedures.We found that 99mTcO4 and colloidal impurities are not the only common radiochemical impurities with 99mTc-tetrofosmin, and shortening of the ITLC strip with respect to the manufacturer's method will worsen system resolution and may produce inaccuracy. Conclusion: The miniaturized methods we descri
- Published
- 2017
40. The Role of Nuclear Cardiac Imaging in Infective Endocarditis
- Author
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Sollini, M, Boni, R, Antunovic, L, Kirienko, M, Lazzeri, E, Erba, P, Sollini M., Boni R., Antunovic L., Kirienko M., Lazzeri E., Erba P. A., Sollini, M, Boni, R, Antunovic, L, Kirienko, M, Lazzeri, E, Erba, P, Sollini M., Boni R., Antunovic L., Kirienko M., Lazzeri E., and Erba P. A.
- Abstract
Purpose of Review: Infective endocarditis (IE) remains a deadly disease despite improvements in its management. Echocardiography is crucial for the diagnosis of IE; however, its value is operator-dependent and its sensitivity can decrease in the presence of valvular prosthesis. This review aims to provide an overview on the role of nuclear cardiac imaging in the diagnosis of IE. Recent Findings: Among all nuclear cardiac imaging modalities, both radiolabeled leukocyte scintigraphy and 2-deoxy-2-[fluorine-18]fluoro-D-glucose positron emission tomography/computed tomography ([18F]FDG-PET/CT) have been recently introduced in the guidelines of European Society of Cardiology (ESC) for the management of IE. The ESC guidelines included some minor criteria (mainly clinical), and two different sets of major criteria based on blood culture and imaging, respectively. The positivity of either radiolabeled leukocyte scintigraphy or [18F]FDG-PET/CT images is considered itself a major criterion to diagnose IE. However., nuclear cardiac imaging analysis may be tricky and methodological and technical aspects should be carefully considered. Summary: Available evidence supports the role of nuclear cardiac imaging in the diagnosis and management of IE. However., all practitioners who act within the “Endocarditis Team” should present a very high level of expertise.
- Published
- 2017
41. The OpenAIRE Research Community Dashboard: On Blending Scientific Workflows and Scientific Publishing
- Author
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Baglioni, M. Bardi, A. Kokogiannaki, A. Manghi, P. Iatropoulou, K. Principe, P. Vieira, A. Nielsen, L.H. Dimitropoulos, H. Foufoulas, I. Manola, N. Atzori, C. La Bruzzo, S. Lazzeri, E. Artini, M. De Bonis, M. Dell’Amico, A.
- Abstract
Despite the hype, the effective implementation of Open Science is hindered by several cultural and technical barriers. Researchers embraced digital science, use “digital laboratories” (e.g. research infrastructures, thematic services) to conduct their research and publish research data, but practices and tools are still far from achieving the expectations of transparency and reproducibility of Open Science. The places where science is performed and the places where science is published are still regarded as different realms. Publishing is still a post-experimental, tedious, manual process, too often limited to articles, in some contexts semantically linked to datasets, rarely to software, generally disregarding digital representations of experiments. In this work we present the OpenAIRE Research Community Dashboard (RCD), designed to overcome some of these barriers for a given research community, minimizing the technical efforts and without renouncing any of the community services or practices. The RCD flanks digital laboratories of research communities with scholarly communication tools for discovering and publishing interlinked scientific products such as literature, datasets, and software. The benefits of the RCD are show-cased by means of two real-case scenarios: the European Marine Science community and the European Plate Observing System (EPOS) research infrastructure. © Springer Nature Switzerland AG 2019.
- Published
- 2019
42. Digital Libraries: supporting Open Science
- Author
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Manghi P., Candela L., Lazzeri E., and Silvello G.
- Subjects
Open Science ,Digital Library - Abstract
The Italian Research Conference on Digital Libraries (IRCDL) is the annual Italian forum to discuss research topics on Digital Libraries and related technical, practical, and social issues. Along the years, IRCDL touched several aspects underlying the "Digital Library" domain and promptly adapted to the evolution of the field. Today, the "Digital Library" field includes theory and practices reflecting the evolution of the role of libraries in the scholarly communication domain, and also embracing scholarly communication and open science.The theme of IRCDL 2019 was "Digital Libraries: Supporting Open Science". Three main reasons motivated this theme: (i) science is increasingly becoming digital, meaning that research is performed using data services and digital tools; (ii) the results of the research are no longer just traditional scientific publications; (iii) the outcomes of science are increasingly encompassing datasets, software, and experiments. As digital artefacts, such products can be shared and re-used together with the article, thus enabling comprehensive research assessment and various degrees of reproducibility of science. Positive consequences of this shift towards open Science are: accelerating science, optimizing the cost of research, fraud detection, and fully-fledged scientific reward. Digital Libraries are central in the evolution of research outputs by target-ing findability, preservation, interlinking, and re-use of research products and by integrating the components of the scholarly communication process
- Published
- 2019
43. Simultaneous dobutamine stress echocardiography and dobutamine scintigraphy (99mTc-MIBI-SPET) for assessment of coronary artery disease
- Author
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Di Bello, V., Riccardo Bellina, C., Molea, N., Talarico, L., Boni, G., Magagnini, E., Matteucci, F., Giorgi, D., Lazzeri, E., Bertini, A., Romano, M. F., Bianchi, R., and Giusti, C.
- Published
- 1996
- Full Text
- View/download PDF
44. Anticlastogenic Effect of Ginkgo Biloba Extract in Graves’ Disease Patients Receiving Radioiodine Therapy
- Author
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Dardano, A, Ballardin, M, Ferdeghini, M, Lazzeri, E, Traino, C, Caraccio, N, Mariani, G, Barale, R, and Monzani, F
- Published
- 2007
45. CXCR3 and αEβ7 integrin identify a subset of CD8+ mature thymocytes that share phenotypic and functional properties with CD8+ gut intraepithelial lymphocytes
- Author
-
Annunziato, F, Cosmi, L, Liotta, F, Lazzeri, E, Romagnani, P, Angeli, R, Lasagni, L, Manetti, R, Marra, F, Gerard, C, Petrai, I, Dello Sbarba, P, Tonelli, F, Maggi, E, and Romagnani, S
- Published
- 2006
46. Hybrid Imaging and Radionuclide Therapy of Musculoskeletal Diseases
- Author
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Duccio Volterrani, Paola Anna Erba, Ignasi Carrió, H. William Strauss, Giuliano Mariani, Erba, P, Sollini, M, Zanca, R, Boni, R, Flynt, L, Lazzeri, E, Mariani, G, Kuwert, T, Erba, Paola Anna, Sollini, Martina, Zanca, Roberta, Boni, Roberto, Flynt, Lesley, Lazzeri, Elena, Mariani, Giuliano, Kuwert, Torsten, Duccio Volterrani, Paola Anna Erba, Ignasi Carrió, H. William Strauss, Giuliano Mariani, Erba, P, Sollini, M, Zanca, R, Boni, R, Flynt, L, Lazzeri, E, Mariani, G, Kuwert, T, Erba, Paola Anna, Sollini, Martina, Zanca, Roberta, Boni, Roberto, Flynt, Lesley, Lazzeri, Elena, Mariani, Giuliano, and Kuwert, Torsten
- Abstract
Bone tissue is a specialized form of connective tissue, to which mineralization of the extracellular matrix confers remarkable hardness and strength.
- Published
- 2019
47. Trocar site tumor recurrences: May pneumoperitoneum be responsible?
- Author
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Cavina, E., Goletti, O., Molea, N., Buccianti, P., Chiarugi, M., Boni, G., Lazzeri, E., and Bianchi, R.
- Published
- 1998
- Full Text
- View/download PDF
48. Detection of a second malignancy in prostate cancer patients by using [18F]Choline PET/CT: A case series
- Author
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Sollini, M, Pasqualetti, F, Perri, M, Coraggio, G, Castellucci, P, Roncali, M, Boni, R, Lazzeri, E, Galeandro, M, Paiar, F, Versari, A, Erba, P, Sollini M., Pasqualetti F., Perri M., Coraggio G., Castellucci P., Roncali M., Boni R., Lazzeri E., Galeandro M., Paiar F., Versari A., Erba P. A., Sollini, M, Pasqualetti, F, Perri, M, Coraggio, G, Castellucci, P, Roncali, M, Boni, R, Lazzeri, E, Galeandro, M, Paiar, F, Versari, A, Erba, P, Sollini M., Pasqualetti F., Perri M., Coraggio G., Castellucci P., Roncali M., Boni R., Lazzeri E., Galeandro M., Paiar F., Versari A., and Erba P. A.
- Abstract
Background: The role of radiolabeled choline (Cho) in patients with biochemical recurrence after radical treatment for prostate cancer (PCA) is well established. Its widespread clinical use has prompted the depiction of incidentalomas, unusual sites of metastatic lesions, as well as false positive and negative cases. We reported a series of patients affected by biochemical recurrence of PCA imaged by [18F]Cho positron emission tomography/computed tomography (PET/CT) which resulted suspected for a second malignancy. Case presentation: [18F]Cho PET/CT was performed in patients with biochemical PCA recurrence. From an internal clinical database we identified patients in which PET/CT resulted suspected for a second malignancy. A second malignancy was suspected in presence of "unusual" site of [18F]Cho uptake not consistent with clinical-instrumental history. Histology was used as reference standard for final diagnosis. Seven PCA patients (76 years, 71-84 years) with the suspicion of a second tumor based on [18F]Cho PET/CT findings were identified. Mean value of PSA at the time of [18F]Cho PET/CT was 2,37 ng/mL. The median time between PCA diagnosis and PET/CT was 6 years (range 0-14 years). In two cases history of a second malignancy (lung cancer and cutaneous basocellular carcinoma) was known (diagnosed 12 and 6 years after PCA, respectively). PET/CT identified 13 sites of [18F]Cho uptake (lung = 5, lymph node = 7, bone = 1). Final diagnosis was consistent with lung cancer in 5/7 cases (first diagnosis = 4/5, recurrence = 1/5), colorectal cancer and nodal metastases from melanoma in 1 case each. Conclusions: Although the clinical usefulness of Cho PET/CT for detecting cancer lesions other than prostate origin is known, for those patients who undergo this examination according to indication, the diagnosis of a second tumor has a significant impact on their therapeutic management.
- Published
- 2016
49. PET/CT and PET/MRI in Neurology: Infection/Inflammation
- Author
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Ciarmiello, A, Mansi, L, Sollini, M, Boni, R, Lazzeri, E, Erba, P, Sollini M., Boni R., Lazzeri E., Erba P. A., Ciarmiello, A, Mansi, L, Sollini, M, Boni, R, Lazzeri, E, Erba, P, Sollini M., Boni R., Lazzeri E., and Erba P. A.
- Abstract
For more than a century, X-ray was the only available modality allowing observation of inner workings of the human body. Today, a new generation of imaging devices is probing even deeper and transforming medicine in the process. Indeed, recent advances in imaging technology such as CT scans, MRIs, SPECT, and PET scans and other techniques have had a major impact on the diagnosis and treatment of disease. Nuclear medicine techniques for imaging inflammation and infection have enormously expanded gaining importance in the diagnostic setting as well as for prognostic implication and management of treatment. This important clinical role relies on the ability of functional imaging to pinpoint different components and phases of inflammatory and infectious diseases beside the pure morphological anomaly generally depicted by the majority of radiological imaging procedures. Indeed, the use of nuclear medicine techniques allows in vivo histological characterization of inflamed and infected tissues and highlights cells and phenomena principally involved, thus allowing definition of tailored personalized treatment.
- Published
- 2016
50. Other imaging modalities in infective endocarditis diagnosis
- Author
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Habib, G, Erba, P, Sollini, M, Boni, R, Lazzeri, E, Erba P. A., Sollini M., Boni R., Lazzeri E., Habib, G, Erba, P, Sollini, M, Boni, R, Lazzeri, E, Erba P. A., Sollini M., Boni R., and Lazzeri E.
- Abstract
The recent development of hybrid molecular imaging equipment for both conventional nuclear medicine (e.g., SPECT/CT) and PET (e.g., PET/CT) has raised evidence of the impact of SPECT and PET performed with suitable infection imaging agents and co-registered with CT in the diagnosis of IE. Their unique whole-body exploring ability, i.e., to detect multiple sites of disease with a single examination, has been proven effective in guiding clinical management of patients in view of the selection of optimal treatment strategy. Radiolabeled leukocytes scintigraphy and [18F]FDG-PET/CT have been recently included in the 2015 Guideline for the management of infective endocarditis and proposed as diagnostic tools in the diagnostic flow chart of IE. In particular, molecular imaging techniques have been proposed to confirm/exclude IE in case of “possible” or “rejected” IE (as for FUO), and to assess the embolic burden in case of “definite” IE. The main added value of using these techniques are the reduction of the rate of misdiagnosed IE, classified in the ‘Possible IE’ category by using the Duke criteria alone and the detection of peripheral embolic and metastatic infectious events. Evidence is higher in case of and prosthetic valve IE (PVE), however, data show increased accuracy also in presence of native IE (NVE) and unconclusive clinical findings. This new approach to IE patient where imaging techniques including nuclear imaging are getting more and more important is based on the concept that IE is not a single disease but, rather, may present with very different aspects, depending on the first organ involved, the underlying cardiac disease (if any), the microorganism involved, the presence or absence of complications, and the patient’s characteristics. Therefore, a very high level of expertise is needed, coming from practitioners from several specialties, including microbiologists, imagers, clinicians and surgeon. Including all these specialists into the patients’ managemen
- Published
- 2016
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