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4. The South African guidelines on enuresis: 2024 update.

Author

Adam, A., Badenhorst, A., Claassen, F., de Maayer, T., Fockema, M., Fredericks, J., Gottlich, E., John, J., Lala, N., Lazarus, J., Leahy, S., Lourens, H. N., Maharaj, S., Mathabe, K . M., Moshokoa, E. M., Mutambirwa, S. B. A., Petersen, K. L., Radzuma, M. B., van der Merwe, A., and van Heerden, I.

Published
2024
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10. A global action agenda for turning the tide on fatty liver disease

Author

Lazarus, J, Mark, H, Allen, A, Arab, J, Carrieri, P, Noureddin, M, Alazawi, W, Alkhouri, N, Alqahtani, S, Anstee, Q, Arrese, M, Bataller, R, Berg, T, Brennan, P, Burra, P, Castro-Narro, G, Cortez-Pinto, H, Cusi, K, Dedes, N, Duseja, A, Francque, S, Gastaldelli, A, Hagström, H, Huang, T, Ivancovsky Wajcman, D, Kautz, A, Kopka, C, Krag, A, Newsome, P, Rinella, M, Romero, D, Sarin, S, Silva, M, Spearman, C, Terrault, N, Tsochatzis, E, Valenti, L, Villota-Rivas, M, Zelber-Sagi, S, Schattenberg, J, Wong, V, Younossi, Z, Perseghin, G, Lazarus, Jeffrey V, Mark, Henry E, Allen, Alina M, Arab, Juan Pablo, Carrieri, Patrizia, Noureddin, Mazen, Alazawi, William, Alkhouri, Naim, Alqahtani, Saleh A, Anstee, Quentin M, Arrese, Marco, Bataller, Ramon, Berg, Thomas, Brennan, Paul N, Burra, Patrizia, Castro-Narro, Graciela E, Cortez-Pinto, Helena, Cusi, Kenneth, Dedes, Nikos, Duseja, Ajay, Francque, Sven M, Gastaldelli, Amalia, Hagström, Hannes, Huang, Terry T K, Ivancovsky Wajcman, Dana, Kautz, Achim, Kopka, Christopher J, Krag, Aleksander, Newsome, Philip N, Rinella, Mary E, Romero, Diana, Sarin, Shiv Kumar, Silva, Marcelo, Spearman, C Wendy, Terrault, Norah A, Tsochatzis, Emmanuel A, Valenti, Luca, Villota-Rivas, Marcela, Zelber-Sagi, Shira, Schattenberg, Jörn M, Wong, Vincent Wai-Sun, Younossi, Zobair M, Perseghin, Gianluca, Lazarus, J, Mark, H, Allen, A, Arab, J, Carrieri, P, Noureddin, M, Alazawi, W, Alkhouri, N, Alqahtani, S, Anstee, Q, Arrese, M, Bataller, R, Berg, T, Brennan, P, Burra, P, Castro-Narro, G, Cortez-Pinto, H, Cusi, K, Dedes, N, Duseja, A, Francque, S, Gastaldelli, A, Hagström, H, Huang, T, Ivancovsky Wajcman, D, Kautz, A, Kopka, C, Krag, A, Newsome, P, Rinella, M, Romero, D, Sarin, S, Silva, M, Spearman, C, Terrault, N, Tsochatzis, E, Valenti, L, Villota-Rivas, M, Zelber-Sagi, S, Schattenberg, J, Wong, V, Younossi, Z, Perseghin, G, Lazarus, Jeffrey V, Mark, Henry E, Allen, Alina M, Arab, Juan Pablo, Carrieri, Patrizia, Noureddin, Mazen, Alazawi, William, Alkhouri, Naim, Alqahtani, Saleh A, Anstee, Quentin M, Arrese, Marco, Bataller, Ramon, Berg, Thomas, Brennan, Paul N, Burra, Patrizia, Castro-Narro, Graciela E, Cortez-Pinto, Helena, Cusi, Kenneth, Dedes, Nikos, Duseja, Ajay, Francque, Sven M, Gastaldelli, Amalia, Hagström, Hannes, Huang, Terry T K, Ivancovsky Wajcman, Dana, Kautz, Achim, Kopka, Christopher J, Krag, Aleksander, Newsome, Philip N, Rinella, Mary E, Romero, Diana, Sarin, Shiv Kumar, Silva, Marcelo, Spearman, C Wendy, Terrault, Norah A, Tsochatzis, Emmanuel A, Valenti, Luca, Villota-Rivas, Marcela, Zelber-Sagi, Shira, Schattenberg, Jörn M, Wong, Vincent Wai-Sun, Younossi, Zobair M, and Perseghin, Gianluca

Abstract

Background and Aims: Fatty liver disease is a major public health threat due to its very high prevalence and related morbidity and mortality. Focused and dedicated interventions are urgently needed to target disease prevention, treatment, and care. Approach and Results: We developed an aligned, prioritized action agenda for the global fatty liver disease community of practice. Following a Delphi methodology over 2 rounds, a large panel (R1 n = 344, R2 n = 288) reviewed the action priorities using Qualtrics XM, indicating agreement using a 4-point Likert-scale and providing written feedback. Priorities were revised between rounds, and in R2, panelists also ranked the priorities within 6 domains: epidemiology, treatment and care, models of care, education and awareness, patient and community perspectives, and leadership and public health policy. The consensus fatty liver disease action agenda encompasses 29 priorities. In R2, the mean percentage of “agree” responses was 82.4%, with all individual priorities having at least a super-majority of agreement (> 66.7% “agree”). The highest-ranked action priorities included collaboration between liver specialists and primary care doctors on early diagnosis, action to address the needs of people living with multiple morbidities, and the incorporation of fatty liver disease into relevant non-communicable disease strategies and guidance. Conclusions: This consensus-driven multidisciplinary fatty liver disease action agenda developed by care providers, clinical researchers, and public health and policy experts provides a path to reduce fatty liver disease prevalence and improve health outcomes. To implement this agenda, concerted efforts will be needed at the global, regional, and national levels.

Published
2024

12. Prehospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2): an ambulance-based, randomised, sham-controlled, blinded, phase 3 trial

Author

Bath, Philip M, Scutt, Polly, Anderson, Craig S, Appleton, Jason P, Berge, Evind, Cala, Lesley, Dixon, Mark, England, Timothy M, Godolphin, Peter J, Havard, Diane, Haywood, Lee, Hepburn, Trish, Krishnan, Kailash, Mair, Grant, Montgomery, Alan A, Muir, Keith, Phillips, Stephen J, Pocock, Stuart, Potter, John, Price, Chris, Randall, Marc, Robinson, Thompson G, Roffe, Christine, Rothwell, Peter M, Sandset, Else C, Sanossian, Nerses, Saver, Jeffrey L, Shone, Angela, Siriwardena, A Niroshan, Wardlaw, Joanna M, Woodhouse, Lisa J, Venables, Graham, Sprigg, Nikola, Amarenco, Pierre, Amoils, Shannon, Jarvis, Malcolm, Sandercock, Peter, Asplund, Kjell, Baigent, Colin, Ankolekar, Sandeep, Howard, Harriet, Lysons, Christopher, Walker, Gemma, Gregory, Hayley, Kirby, James, Smithson, Jennifer, Keeling, Joanne, Frowd, Nadia, Gray, Robert, Dooley, Richard, Clarke, Wim, Robinson, Patricia, Law, Zhe Kang, Hodgson, Sheila, Millington, Adam, Sakka, Eleni, Buchanan, David, Palmer, Jeb, Shaw, D, Cobb, H, Johnson, R, Payne, T, Spaight, R, Spaight, A, Sajid, M A, Whileman, A, Hall, E, Cripps, H, Toms, J, Gascoyne, R, Wright, S, Cooper, M, Palfreman, A, Rajapakse, A, Wynter, I, Musarrat, K, Mistri, A, Patel, C, Stephens, C, Khan, S, Patras, S, Soliman, M, Elmarimi, A, Hewitt, C, Watson, E, Wahishi, I, Hindle, J, Perkin, L, Wills, M, Arif, S, Leach, S, Butler, S, O'Kane, D, Smith, C, O'Callaghan, J, Sunman, W, Buck, A, Jackson, B, Richardson, C, Wilkes, G, Clarke, J, Ryan, L, Matias, O, Mangion, D, Hardwick, A, Constantin, C, Thomas, I, Netherton, K, Markova, S, Hedstrom, A, Rushton, B, Hyde, C, Scott, J, Blair, M, Maddula, M, Donnelly, R, Keane, S, Johnson, S, McKenzie, H, Banerjee, A, Hutchinson, D, Goodhand, H, Hill, J, Mellows, K, Cheeseman, M, McTaggart, V, Foster, T, Prothero, L, Saksena, P, O'Kelly, A, Wyllie, H, Hacon, C, Nutt, H, North, J, Goffin, K, Potter, J, Wiltshire, A, Ravenhill, G, Metcalf, K, Ford, L, Langley, M, Davison, W, Subramonian, S, Magezi, F, Obi, I, Temple, N, Butterworth-Cowin, N, Oqwusu-Agyei, P, Azim, A F M, Nicolson, A, Imam, J, White, J, Wood, L, Fothergill, R, Thompson, N, Lazarus, J, Werts, H, Sztriha, L, Ho, C, McKenzie, E, Owoyele, E, Lim, J, Aeron-Thomas, J, Dockey, M, Sylvester, N, Rao, P, Bloom, B M, Erumere, E, Norman, G, Skene, I, Cuenoud, L, Howaniec, L, Boulton, O, Daboo, P, Michael, R, Al-Saadi, S, Harrison, T, Syed, H, Argandona, L, Amiani, S, Perry, R, Ashton, A, Banaras, A, Hogan, C, Watchurst, C, Elliott, E, Francia, N, Oji, N, Erande, R, Obarey, S, Feerick, S, Tshuma, S, England, E, Pocock, H, Poole, K, Manchanda, S, Burn, I, Dayal, S, McNee, K, Robinson, M, Hancock, R, South, A, Holmes, C, Steele, A, Guthrie, L B, Oborn, M, Nor, A Mohd, Hyams, B, Eglinton, C, Waugh, D, Cann, E, Wilmhurst, N, Piesley, S, Shave, S, Dutta, D, Obeid, M, Ward, D, Turfrey, J, Glass, J, Bowstead, K, Hill, L, Brown, P, Beames, S, O'Connell, S, Hughes, V, Whiting, R, Gagg, J, Hussain, M, Harvey, M, Karunatilake, D, Pusuluri, B, Witcher, A, Pawley, C, Allen, J, Foot, J, Rowe, J, Lane, C, Ragab, S, Wadams, B, Dube, J, Jupp, B, Ljubez, A, Bagnall, C, Hann, G, Tucker, L, Kelton, M, Orr, S, Harrington, F, James, A, Lydon, A, Courtauld, G, Bond, K, Lucas, L, Nisbett, T, Kubie, J, Bowring, A, Jennings, G, Thorpe, K, Mason, N, Keenan, S, Gbadomishi, L, Howcroft, D, Newton, H, Choulerton, J, Avis, J, Shaw, L, Paterson, P, Kaye, P, Hierons, S, Lucas, S, Clatworthy, P, Faulkner, B, Rannigan, L, Worner, R, Bhaskaran, B, Saulat, A, Bearne, H, Garfield-Smith, J, Horan, K, Fitzell, P, Szabo, S, Haley, M, Simmons, D, Cotterill, D, Saunders, G, Dymond, H, Beech, S, Rashed, K, Tanate, A, Buckley, C, Wood, D, Matthews, L, Board, S, Pitt-Kirby, T, Rees, N, Convery, C, Jones, P, Bryant, C, Tench, H, Dixon, M, Loosley, R, Coetzee, S, Jones, S, Sims, T, Krishnan, M, Davies, C, Quinn, L, Connor, L, Wani, M, Storton, S, Treadwell, S, Anjum, T, Somashekar, C, Chandler, A, Triscott, C, Bevan, L, Sander, M, Buckle, S, Sayed, W, Andrews, K, Hughes, L, Hughes, R, Ward, M, Pretty, A, Rosser, A, Davidson, B, Price, G, Gunson, I, Lumley-Holmes, J, Miller, J, Larden, M, Jhamat, M, Horwood, P, Boldy, R, Jenkins, C, Price, F, Harrison, M, Martin, T, Ahmad, N, Willberry, A, Stevens, A, Fotherby, K, Barry, A, Remegoso, A, Alipio, F, Maquire, H, Hiden, J, Finney, K, Varquez, R, Ispoglou, S, Hayes, A, Gull, D, Evans, R, Epstein, E, Hurdowar, S, Crossley, J, Miles, J, Hird, K, Pilbery, R, Patterson, C, Ramadan, H, Stewart, K, Quinn, O, Bellfield, R, Macquire, S, Gaba, W, Nair, A, Wilson, A, Hawksworth, C, Alam, I, Greig, J, Gomes, P, Rana, P, Ahmed, Z, Anderston, P, Neal, A, Walstow, D, Fong, R, Brotheridge, S, Bwalya, A, Gillespie, A, Midgley, C, Hare, C, Lyon, H, Stephenson, L, Broome, M, Worton, R, Jackson, S, Rayessa, R, Abdul-Hamid, A, Naylor, C, Clarkson, E, Hassan, A, Veraque, E, Finch, L, Makawa, L, Carpenter, M, Datta, P, Needle, A, Jackson, L, Brooke, H J, Ball, J, Lowry, T, Punnoose, S, Walker, R, Murray, V, Ali, A, Kamara, C, Doyle, C, Richards, E, Howe, J, Dakin, K, Harkness, K, Lindert, R, Wanklyn, P, Willcoxson, P, Clark-Brown, P, and Mir, R

Published
2019
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13. Hepatitis B and C in Europe: an update from the Global Burden of Disease Study 2019

Author

Cortesi, P, Fornari, C, Conti, S, Antonazzo, I, Ferrara, P, Ahmed, A, Andrei, C, Andrei, T, Artamonov, A, Banach, M, Baravelli, C, Barnighausen, T, Bhagavathula, A, Briko, N, Calina, D, Carreras, G, Chung, S, Dianatinasab, M, Dubljanin, E, Durojaiye, O, Ezeonwumelu, I, Fagbamigbe, A, Fischer, F, Gallus, S, Glushkova, E, Golinelli, D, Gorini, G, Hassan, S, Hay, S, Hostiuc, M, Ilic, I, Ilic, M, Jakovljevic, M, Jamshidi, E, Jozwiak, J, Kabir, Z, Kauppila, J, Khalilov, R, Khan, M, Khatab, K, Koyanagi, A, La Vecchia, C, Lazarus, J, Ledda, C, Levi, M, Lopukhov, P, Loureiro, J, Matthews, P, Mentis, A, Mestrovic, T, Moazen, B, Mohammed, S, Monasta, L, Mulita, F, Murray, C, Negoi, I, Oancea, B, Palladino, C, Patel, J, Petcu, I, Postma, M, Rawaf, D, Rawaf, S, Romero-Rodriguez, E, Santric-Milicevic, M, Skryabin, V, Skryabina, A, Tabares-Seisdedos, R, Tampa, M, Taveira, N, Thiyagarajan, A, Tovani-Palone, M, Westerman, R, Zastrozhin, M, Mazzaglia, G, Mantovani, L, Cortesi P. A., Fornari C., Conti S., Antonazzo I. C., Ferrara P., Ahmed A., Andrei C. L., Andrei T., Artamonov A. A., Banach M., Baravelli C. M., Barnighausen T. W., Bhagavathula A. S., Briko N. I., Calina D., Carreras G., Chung S. -C., Dianatinasab M., Dubljanin E., Durojaiye O. C., Ezeonwumelu I. J., Fagbamigbe A. F., Fischer F., Gallus S., Glushkova E. V., Golinelli D., Gorini G., Hassan S., Hay S. I., Hostiuc M., Ilic I. M., Ilic M. D., Jakovljevic M., Jamshidi E., Jozwiak J. J., Kabir Z., Kauppila J. H., Khalilov R., Khan M. A., Khatab K., Koyanagi A., La Vecchia C., Lazarus J. V., Ledda C., Levi M., Lopukhov P. D., Loureiro J. A., Matthews P. C., Mentis A. -F. A., Mestrovic T., Moazen B., Mohammed S., Monasta L., Mulita F., Murray C. J. L., Negoi I., Oancea B., Palladino C., Patel J., Petcu I. -R., Postma M. J., Rawaf D. L., Rawaf S., Romero-Rodriguez E., Santric-Milicevic M. M., Skryabin V. Y., Skryabina A. A., Tabares-Seisdedos R., Tampa M., Taveira N., Thiyagarajan A., Tovani-Palone M. R., Westerman R., Zastrozhin M. S., Mazzaglia G., Mantovani L. G., Cortesi, P, Fornari, C, Conti, S, Antonazzo, I, Ferrara, P, Ahmed, A, Andrei, C, Andrei, T, Artamonov, A, Banach, M, Baravelli, C, Barnighausen, T, Bhagavathula, A, Briko, N, Calina, D, Carreras, G, Chung, S, Dianatinasab, M, Dubljanin, E, Durojaiye, O, Ezeonwumelu, I, Fagbamigbe, A, Fischer, F, Gallus, S, Glushkova, E, Golinelli, D, Gorini, G, Hassan, S, Hay, S, Hostiuc, M, Ilic, I, Ilic, M, Jakovljevic, M, Jamshidi, E, Jozwiak, J, Kabir, Z, Kauppila, J, Khalilov, R, Khan, M, Khatab, K, Koyanagi, A, La Vecchia, C, Lazarus, J, Ledda, C, Levi, M, Lopukhov, P, Loureiro, J, Matthews, P, Mentis, A, Mestrovic, T, Moazen, B, Mohammed, S, Monasta, L, Mulita, F, Murray, C, Negoi, I, Oancea, B, Palladino, C, Patel, J, Petcu, I, Postma, M, Rawaf, D, Rawaf, S, Romero-Rodriguez, E, Santric-Milicevic, M, Skryabin, V, Skryabina, A, Tabares-Seisdedos, R, Tampa, M, Taveira, N, Thiyagarajan, A, Tovani-Palone, M, Westerman, R, Zastrozhin, M, Mazzaglia, G, Mantovani, L, Cortesi P. A., Fornari C., Conti S., Antonazzo I. C., Ferrara P., Ahmed A., Andrei C. L., Andrei T., Artamonov A. A., Banach M., Baravelli C. M., Barnighausen T. W., Bhagavathula A. S., Briko N. I., Calina D., Carreras G., Chung S. -C., Dianatinasab M., Dubljanin E., Durojaiye O. C., Ezeonwumelu I. J., Fagbamigbe A. F., Fischer F., Gallus S., Glushkova E. V., Golinelli D., Gorini G., Hassan S., Hay S. I., Hostiuc M., Ilic I. M., Ilic M. D., Jakovljevic M., Jamshidi E., Jozwiak J. J., Kabir Z., Kauppila J. H., Khalilov R., Khan M. A., Khatab K., Koyanagi A., La Vecchia C., Lazarus J. V., Ledda C., Levi M., Lopukhov P. D., Loureiro J. A., Matthews P. C., Mentis A. -F. A., Mestrovic T., Moazen B., Mohammed S., Monasta L., Mulita F., Murray C. J. L., Negoi I., Oancea B., Palladino C., Patel J., Petcu I. -R., Postma M. J., Rawaf D. L., Rawaf S., Romero-Rodriguez E., Santric-Milicevic M. M., Skryabin V. Y., Skryabina A. A., Tabares-Seisdedos R., Tampa M., Taveira N., Thiyagarajan A., Tovani-Palone M. R., Westerman R., Zastrozhin M. S., Mazzaglia G., and Mantovani L. G.

Abstract

Background: In 2016, the World Health Assembly adopted the resolution to eliminate viral hepatitis by 2030. This study aims to provide an overview of the burdens of hepatitis B virus (HBV) and hepatitis C virus (HCV) in Europe and their changes from 2010 to 2019 using estimates from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. Methods: We used GBD 2019 estimates of the burden associated with HBV-related and HCV-related diseases: acute hepatitis, cirrhosis and other chronic liver diseases, and liver cancer. We report total numbers and age-standardised rates per 100 000 for mortality, prevalence, incidence, and disability-adjusted life-years (DALYs) from 2010 to 2019. For each HBV-related and HCV-related disease and each measure, we analysed temporal changes and percentage changes for the 2010–19 period. Findings: In 2019, across all age groups, there were an estimated 2·08 million (95% uncertainty interval [UI] 1·66 to 2·54) incident cases of acute hepatitis B and 0·49 million (0·42 to 0·57) of hepatitis C in Europe. There were an estimated 8·24 million (7·56 to 8·88) prevalent cases of HBV-related cirrhosis and 11·87 million (9·77 to 14·41) of HCV-related cirrhosis, with 24·92 thousand (19·86 to 31·03) deaths due to HBV-related cirrhosis and 36·89 thousand (29·94 to 45·56) deaths due to HCV-related cirrhosis. Deaths were estimated at 9·00 thousand (6·88 to 11·62) due to HBV-related liver cancer and 23·07 thousand (18·95 to 27·31) due to HCV-related liver cancer. Between 2010 and 2019, the age-standardised incidence rate of acute hepatitis B decreased (–22·14% [95% UI –35·44 to –5·98]) as did its age-standardised mortality rate (–33·27% [–43·03 to –25·49]); the age-standardised prevalence rate (–20·60% [–22·09 to –19·10]) and mortality rate (–33·19% [–37·82 to –28·13]) of HBV-related cirrhosis also decreased in this time period. The age-standardised incidence rate of acute hepatitis C decreased by 3·24% (1·17 to 5·02) and its age-standa

Published
2023

14. A global research priority agenda to advance public health responses to fatty liver disease

Author

Lazarus, J, Mark, H, Allen, A, Arab, J, Carrieri, P, Noureddin, M, Alazawi, W, Alkhouri, N, Alqahtani, S, Arrese, M, Bataller, R, Berg, T, Brennan, P, Burra, P, Castro-Narro, G, Cortez-Pinto, H, Cusi, K, Dedes, N, Duseja, A, Francque, S, Hagstrom, H, Huang, T, Wajcman, D, Kautz, A, Kopka, C, Krag, A, Miller, V, Newsome, P, Rinella, M, Romero, D, Sarin, S, Silva, M, Spearman, C, Tsochatzis, E, Valenti, L, Villota-Rivas, M, Zelber-Sagi, S, Schattenberg, J, Wong, V, Younossi, Z, Aberg, F, Adams, L, Al-Naamani, K, Albadawy, R, Alexa, Z, Allison, M, Alnaser, F, Alswat, K, Alvares-da-Silva, M, Alvaro, D, Alves-Bezerra, M, Andrade, R, Anstee, Q, Awuku, Y, Baatarkhuu, O, Baffy, G, Bakieva, S, Bansal, M, Barouki, R, Batterham, R, Behling, C, Belfort-DeAguiar, R, Berzigotti, A, Betel, M, Bianco, C, Bosi, E, Boursier, J, Brunt, E, Bugianesi, E, Byrne, C, Cabrera Cabrejos, M, Caldwell, S, Carr, R, Castellanos Fernandez, M, Castera, L, Castillo-Lopez, M, Caussy, C, Cerda-Reyes, E, Ceriello, A, Chan, W, Chang, Y, Charatcharoenwitthaya, P, Chavez-Tapia, N, Chung, R, Colombo, M, Coppell, K, Cotrim, H, Craxi, A, Crespo, J, Dassanayake, A, Davidson, N, De Knegt, R, de Ledinghen, V, Demir, M, Desalegn, H, Diago, M, Dillon, J, Dimmig, B, Dirac, M, Dirchwolf, M, Dufour, J, Dvorak, K, Ekstedt, M, El-Kassas, M, Elsanousi, O, Elsharkawy, A, Elwakil, R, Eskridge, W, Eslam, M, Esmat, G, Fan, J, Ferraz, M, Flisiak, R, Fortin, D, Fouad, Y, Freidman, S, Fuchs, M, Gadano, A, Gastaldelli, A, Geerts, A, Geier, A, George, J, Gerber, L, Ghazinyan, H, Gheorghe, L, Kile, D, Girala, M, Boon Bee, G, Goossens, N, Graupera, I, Gronbaek, H, Hamid, S, Hebditch, V, Henry, Z, Hickman, I, Hobbs, L, Hocking, S, Hofmann, W, Idilman, R, Iruzubieta, P, Isaacs, S, Isakov, V, Ismail, M, Jamal, M, Jarvis, H, Jepsen, P, Jornayvaz, F, Sudhamshu, K, Kakizaki, S, Karpen, S, Kawaguchi, T, Keating, S, Khader, Y, Kim, S, Kim, W, Kleiner, D, Koek, G, Joseph Komas, N, Kondili, L, Koot, B, Korenjak, M, Kotsiliti, E, Koulla, Y, Kugelmas, C, Kugelmas, M, Labidi, A, Lange, N, Lavine, J, Lazo, M, Leite, N, Lin, H, Lkhagvaa, U, Long, M, Lopez-Jaramillo, P, Lozano, A, Macedo, M, Malekzadeh, R, Marchesini, G, Marciano, S, Martinez, K, Martinez Vazquez, S, Mateva, L, Mato, J, Nlombi, C, Mccary, A, Mcintyre, J, Mckee, M, Mendive, J, Mikolasevic, I, Miller, P, Milovanovic, T, Milton, T, Moreno-Alcantar, R, Morgan, T, Motala, A, Muris, J, Musso, C, Nava-Gonzalez, E, Negro, F, Nersesov, A, Neuschwander-Tetri, B, Nikolova, D, Norris, S, Novak, K, Ocama, P, Ong, J, Ong-Go, A, Onyekwere, C, Padilla, M, Pais, R, Pan, C, Panduro, A, Panigrahi, M, Papatheodoridis, G, Paruk, I, Patel, K, Goncalves, C, Figueroa, M, Perez-Escobar, J, Pericas, J, Perseghin, G, Pessoa, M, Petta, S, Marques Souza de Oliveira, C, Prabhakaran, D, Pyrsopoulous, N, Rabiee, A, Ramji, A, Ratziu, V, Ravendhran, N, Ray, K, Roden, M, Romeo, S, Romero-Gomez, M, Rotman, Y, Rouabhia, S, Rowe, I, Sadirova, S, Alkhatry, M, Salupere, R, Satapathy, S, Schwimmer, J, Sebastiani, G, Seim, L, Seki, Y, Serme, A, Shapiro, D, Sharvadze, L, Shaw, J, Shawa, I, Shenoy, T, Shibolet, O, Shimakawa, Y, Shubrook, J, Singh, S, Sinkala, E, Skladany, L, Skrypnyk, I, Song, M, Sookoian, S, Sridharan, K, Stefan, N, Stine, J, Stratakis, N, Sheriff, D, Sundaram, S, Svegliati-Baroni, G, Swain, M, Tacke, F, Taheri, S, Tan, S, Tapper, E, Targher, G, Tcaciuc, E, Thiele, M, Tiniakos, D, Tolmane, I, Torre, A, Torres, E, Treeprasertsuk, S, Trenell, M, Turcan, S, Turcanu, A, Valantinas, J, van Kleef, L, Velarde Ruiz Velasco, J, Vesterhus, M, Vilar-Gomez, E, Waked, I, Wattacheril, J, Wedemeyer, H, Wilkins, F, Willemse, J, Wong, R, Yilmaz, Y, Yki-Jarvinen, H, Yu, M, Yumuk, V, Zeybel, M, Zheng, K, Zheng, M, Lazarus J. V., Mark H. E., Allen A. M., Arab J. P., Carrieri P., Noureddin M., Alazawi W., Alkhouri N., Alqahtani S. A., Arrese M., Bataller R., Berg T., Brennan P. N., Burra P., Castro-Narro G. E., Cortez-Pinto H., Cusi K., Dedes N., Duseja A., Francque S. M., Hagstrom H., Huang T. T. -K., Wajcman D. I., Kautz A., Kopka C. J., Krag A., Miller V., Newsome P. N., Rinella M. E., Romero D., Sarin S. K., Silva M., Spearman C. W., Tsochatzis E. A., Valenti L., Villota-Rivas M., Zelber-Sagi S., Schattenberg J. M., Wong V. W. -S., Younossi Z. M., Aberg F., Adams L., Al-Naamani K., Albadawy R. M., Alexa Z., Allison M., Alnaser F. A., Alswat K., Alvares-da-Silva M. R., Alvaro D., Alves-Bezerra M., Andrade R. J., Anstee Q. M., Awuku Y. A., Baatarkhuu O., Baffy G., Bakieva S., Bansal M. B., Barouki R., Batterham R. L., Behling C., Belfort-DeAguiar R., Berzigotti A., Betel M., Bianco C., Bosi E., Boursier J., Brunt E. M., Bugianesi E., Byrne C. J., Cabrera Cabrejos M. C., Caldwell S., Carr R., Castellanos Fernandez M. I., Castera L., Castillo-Lopez M. G., Caussy C., Cerda-Reyes E., Ceriello A., Chan W. -K., Chang Y., Charatcharoenwitthaya P., Chavez-Tapia N., Chung R. T., Colombo M., Coppell K., Cotrim H. P., Craxi A., Crespo J., Dassanayake A., Davidson N. O., De Knegt R., de Ledinghen V., Demir M., Desalegn H., Diago M., Dillon J. F., Dimmig B., Dirac M. A., Dirchwolf M., Dufour J. -F., Dvorak K., Ekstedt M., El-Kassas M., Elsanousi O. M., Elsharkawy A. M., Elwakil R., Eskridge W., Eslam M., Esmat G., Fan J. -G., Ferraz M. L., Flisiak R., Fortin D., Fouad Y., Freidman S. L., Fuchs M., Gadano A., Gastaldelli A., Geerts A., Geier A., George J., Gerber L. H., Ghazinyan H., Gheorghe L., Kile D. G., Girala M., Boon Bee G. G., Goossens N., Graupera I., Gronbaek H., Hamid S., Hebditch V., Henry Z., Hickman I. J., Hobbs L. A., Hocking S. L., Hofmann W. P., Idilman R., Iruzubieta P., Isaacs S., Isakov V. A., Ismail M. H., Jamal M. H., Jarvis H., Jepsen P., Jornayvaz F., Sudhamshu K. C., Kakizaki S., Karpen S., Kawaguchi T., Keating S. E., Khader Y., Kim S. U., Kim W., Kleiner D. E., Koek G., Joseph Komas N. P., Kondili L. A., Koot B. G., Korenjak M., Kotsiliti E., Koulla Y., Kugelmas C., Kugelmas M., Labidi A., Lange N. F., Lavine J. E., Lazo M., Leite N., Lin H. -C., Lkhagvaa U., Long M. T., Lopez-Jaramillo P., Lozano A., Macedo M. P., Malekzadeh R., Marchesini G., Marciano S., Martinez K., Martinez Vazquez S. E., Mateva L., Mato J. M., Nlombi C. M., McCary A. G., McIntyre J., McKee M., Mendive J. M., Mikolasevic I., Miller P. S., Milovanovic T., Milton T., Moreno-Alcantar R., Morgan T. R., Motala A., Muris J., Musso C., Nava-Gonzalez E. J., Negro F., Nersesov A. V., Neuschwander-Tetri B. A., Nikolova D., Norris S., Novak K., Ocama P., Ong J. P., Ong-Go A., Onyekwere C., Padilla M., Pais R., Pan C., Panduro A., Panigrahi M. K., Papatheodoridis G., Paruk I., Patel K., Goncalves C. P., Figueroa M. P., Perez-Escobar J., Pericas J. M., Perseghin G., Pessoa M. G., Petta S., Marques Souza de Oliveira C. P., Prabhakaran D., Pyrsopoulous N., Rabiee A., Ramji A., Ratziu V., Ravendhran N., Ray K., Roden M., Romeo S., Romero-Gomez M., Rotman Y., Rouabhia S., Rowe I. A., Sadirova S., Alkhatry M. S., Salupere R., Satapathy S. K., Schwimmer J. B., Sebastiani G., Seim L., Seki Y., Serme A. K., Shapiro D., Sharvadze L., Shaw J. E., Shawa I. T., Shenoy T., Shibolet O., Shimakawa Y., Shubrook J. H., Singh S. P., Sinkala E., Skladany L., Skrypnyk I., Song M. J., Sookoian S., Sridharan K., Stefan N., Stine J. G., Stratakis N., Sheriff D. S., Sundaram S. S., Svegliati-Baroni G., Swain M. G., Tacke F., Taheri S., Tan S. -S., Tapper E. B., Targher G., Tcaciuc E., Thiele M., Tiniakos D., Tolmane I., Torre A., Torres E. A., Treeprasertsuk S., Trenell M., Turcan S., Turcanu A., Valantinas J., van Kleef L. A., Velarde Ruiz Velasco J. A., Vesterhus M., Vilar-Gomez E., Waked I., Wattacheril J., Wedemeyer H., Wilkins F., Willemse J., Wong R. J., Yilmaz Y., Yki-Jarvinen H., Yu M. -L., Yumuk V., Zeybel M., Zheng K. I., Zheng M. -H., Lazarus, J, Mark, H, Allen, A, Arab, J, Carrieri, P, Noureddin, M, Alazawi, W, Alkhouri, N, Alqahtani, S, Arrese, M, Bataller, R, Berg, T, Brennan, P, Burra, P, Castro-Narro, G, Cortez-Pinto, H, Cusi, K, Dedes, N, Duseja, A, Francque, S, Hagstrom, H, Huang, T, Wajcman, D, Kautz, A, Kopka, C, Krag, A, Miller, V, Newsome, P, Rinella, M, Romero, D, Sarin, S, Silva, M, Spearman, C, Tsochatzis, E, Valenti, L, Villota-Rivas, M, Zelber-Sagi, S, Schattenberg, J, Wong, V, Younossi, Z, Aberg, F, Adams, L, Al-Naamani, K, Albadawy, R, Alexa, Z, Allison, M, Alnaser, F, Alswat, K, Alvares-da-Silva, M, Alvaro, D, Alves-Bezerra, M, Andrade, R, Anstee, Q, Awuku, Y, Baatarkhuu, O, Baffy, G, Bakieva, S, Bansal, M, Barouki, R, Batterham, R, Behling, C, Belfort-DeAguiar, R, Berzigotti, A, Betel, M, Bianco, C, Bosi, E, Boursier, J, Brunt, E, Bugianesi, E, Byrne, C, Cabrera Cabrejos, M, Caldwell, S, Carr, R, Castellanos Fernandez, M, Castera, L, Castillo-Lopez, M, Caussy, C, Cerda-Reyes, E, Ceriello, A, Chan, W, Chang, Y, Charatcharoenwitthaya, P, Chavez-Tapia, N, Chung, R, Colombo, M, Coppell, K, Cotrim, H, Craxi, A, Crespo, J, Dassanayake, A, Davidson, N, De Knegt, R, de Ledinghen, V, Demir, M, Desalegn, H, Diago, M, Dillon, J, Dimmig, B, Dirac, M, Dirchwolf, M, Dufour, J, Dvorak, K, Ekstedt, M, El-Kassas, M, Elsanousi, O, Elsharkawy, A, Elwakil, R, Eskridge, W, Eslam, M, Esmat, G, Fan, J, Ferraz, M, Flisiak, R, Fortin, D, Fouad, Y, Freidman, S, Fuchs, M, Gadano, A, Gastaldelli, A, Geerts, A, Geier, A, George, J, Gerber, L, Ghazinyan, H, Gheorghe, L, Kile, D, Girala, M, Boon Bee, G, Goossens, N, Graupera, I, Gronbaek, H, Hamid, S, Hebditch, V, Henry, Z, Hickman, I, Hobbs, L, Hocking, S, Hofmann, W, Idilman, R, Iruzubieta, P, Isaacs, S, Isakov, V, Ismail, M, Jamal, M, Jarvis, H, Jepsen, P, Jornayvaz, F, Sudhamshu, K, Kakizaki, S, Karpen, S, Kawaguchi, T, Keating, S, Khader, Y, Kim, S, Kim, W, Kleiner, D, Koek, G, Joseph Komas, N, Kondili, L, Koot, B, Korenjak, M, Kotsiliti, E, Koulla, Y, Kugelmas, C, Kugelmas, M, Labidi, A, Lange, N, Lavine, J, Lazo, M, Leite, N, Lin, H, Lkhagvaa, U, Long, M, Lopez-Jaramillo, P, Lozano, A, Macedo, M, Malekzadeh, R, Marchesini, G, Marciano, S, Martinez, K, Martinez Vazquez, S, Mateva, L, Mato, J, Nlombi, C, Mccary, A, Mcintyre, J, Mckee, M, Mendive, J, Mikolasevic, I, Miller, P, Milovanovic, T, Milton, T, Moreno-Alcantar, R, Morgan, T, Motala, A, Muris, J, Musso, C, Nava-Gonzalez, E, Negro, F, Nersesov, A, Neuschwander-Tetri, B, Nikolova, D, Norris, S, Novak, K, Ocama, P, Ong, J, Ong-Go, A, Onyekwere, C, Padilla, M, Pais, R, Pan, C, Panduro, A, Panigrahi, M, Papatheodoridis, G, Paruk, I, Patel, K, Goncalves, C, Figueroa, M, Perez-Escobar, J, Pericas, J, Perseghin, G, Pessoa, M, Petta, S, Marques Souza de Oliveira, C, Prabhakaran, D, Pyrsopoulous, N, Rabiee, A, Ramji, A, Ratziu, V, Ravendhran, N, Ray, K, Roden, M, Romeo, S, Romero-Gomez, M, Rotman, Y, Rouabhia, S, Rowe, I, Sadirova, S, Alkhatry, M, Salupere, R, Satapathy, S, Schwimmer, J, Sebastiani, G, Seim, L, Seki, Y, Serme, A, Shapiro, D, Sharvadze, L, Shaw, J, Shawa, I, Shenoy, T, Shibolet, O, Shimakawa, Y, Shubrook, J, Singh, S, Sinkala, E, Skladany, L, Skrypnyk, I, Song, M, Sookoian, S, Sridharan, K, Stefan, N, Stine, J, Stratakis, N, Sheriff, D, Sundaram, S, Svegliati-Baroni, G, Swain, M, Tacke, F, Taheri, S, Tan, S, Tapper, E, Targher, G, Tcaciuc, E, Thiele, M, Tiniakos, D, Tolmane, I, Torre, A, Torres, E, Treeprasertsuk, S, Trenell, M, Turcan, S, Turcanu, A, Valantinas, J, van Kleef, L, Velarde Ruiz Velasco, J, Vesterhus, M, Vilar-Gomez, E, Waked, I, Wattacheril, J, Wedemeyer, H, Wilkins, F, Willemse, J, Wong, R, Yilmaz, Y, Yki-Jarvinen, H, Yu, M, Yumuk, V, Zeybel, M, Zheng, K, Zheng, M, Lazarus J. V., Mark H. E., Allen A. M., Arab J. P., Carrieri P., Noureddin M., Alazawi W., Alkhouri N., Alqahtani S. A., Arrese M., Bataller R., Berg T., Brennan P. N., Burra P., Castro-Narro G. E., Cortez-Pinto H., Cusi K., Dedes N., Duseja A., Francque S. M., Hagstrom H., Huang T. T. -K., Wajcman D. I., Kautz A., Kopka C. J., Krag A., Miller V., Newsome P. N., Rinella M. E., Romero D., Sarin S. K., Silva M., Spearman C. W., Tsochatzis E. A., Valenti L., Villota-Rivas M., Zelber-Sagi S., Schattenberg J. M., Wong V. W. -S., Younossi Z. M., Aberg F., Adams L., Al-Naamani K., Albadawy R. M., Alexa Z., Allison M., Alnaser F. A., Alswat K., Alvares-da-Silva M. R., Alvaro D., Alves-Bezerra M., Andrade R. J., Anstee Q. M., Awuku Y. A., Baatarkhuu O., Baffy G., Bakieva S., Bansal M. B., Barouki R., Batterham R. L., Behling C., Belfort-DeAguiar R., Berzigotti A., Betel M., Bianco C., Bosi E., Boursier J., Brunt E. M., Bugianesi E., Byrne C. J., Cabrera Cabrejos M. C., Caldwell S., Carr R., Castellanos Fernandez M. I., Castera L., Castillo-Lopez M. G., Caussy C., Cerda-Reyes E., Ceriello A., Chan W. -K., Chang Y., Charatcharoenwitthaya P., Chavez-Tapia N., Chung R. T., Colombo M., Coppell K., Cotrim H. P., Craxi A., Crespo J., Dassanayake A., Davidson N. O., De Knegt R., de Ledinghen V., Demir M., Desalegn H., Diago M., Dillon J. F., Dimmig B., Dirac M. A., Dirchwolf M., Dufour J. -F., Dvorak K., Ekstedt M., El-Kassas M., Elsanousi O. M., Elsharkawy A. M., Elwakil R., Eskridge W., Eslam M., Esmat G., Fan J. -G., Ferraz M. L., Flisiak R., Fortin D., Fouad Y., Freidman S. L., Fuchs M., Gadano A., Gastaldelli A., Geerts A., Geier A., George J., Gerber L. H., Ghazinyan H., Gheorghe L., Kile D. G., Girala M., Boon Bee G. G., Goossens N., Graupera I., Gronbaek H., Hamid S., Hebditch V., Henry Z., Hickman I. J., Hobbs L. A., Hocking S. L., Hofmann W. P., Idilman R., Iruzubieta P., Isaacs S., Isakov V. A., Ismail M. H., Jamal M. H., Jarvis H., Jepsen P., Jornayvaz F., Sudhamshu K. C., Kakizaki S., Karpen S., Kawaguchi T., Keating S. E., Khader Y., Kim S. U., Kim W., Kleiner D. E., Koek G., Joseph Komas N. P., Kondili L. A., Koot B. G., Korenjak M., Kotsiliti E., Koulla Y., Kugelmas C., Kugelmas M., Labidi A., Lange N. F., Lavine J. E., Lazo M., Leite N., Lin H. -C., Lkhagvaa U., Long M. T., Lopez-Jaramillo P., Lozano A., Macedo M. P., Malekzadeh R., Marchesini G., Marciano S., Martinez K., Martinez Vazquez S. E., Mateva L., Mato J. M., Nlombi C. M., McCary A. G., McIntyre J., McKee M., Mendive J. M., Mikolasevic I., Miller P. S., Milovanovic T., Milton T., Moreno-Alcantar R., Morgan T. R., Motala A., Muris J., Musso C., Nava-Gonzalez E. J., Negro F., Nersesov A. V., Neuschwander-Tetri B. A., Nikolova D., Norris S., Novak K., Ocama P., Ong J. P., Ong-Go A., Onyekwere C., Padilla M., Pais R., Pan C., Panduro A., Panigrahi M. K., Papatheodoridis G., Paruk I., Patel K., Goncalves C. P., Figueroa M. P., Perez-Escobar J., Pericas J. M., Perseghin G., Pessoa M. G., Petta S., Marques Souza de Oliveira C. P., Prabhakaran D., Pyrsopoulous N., Rabiee A., Ramji A., Ratziu V., Ravendhran N., Ray K., Roden M., Romeo S., Romero-Gomez M., Rotman Y., Rouabhia S., Rowe I. A., Sadirova S., Alkhatry M. S., Salupere R., Satapathy S. K., Schwimmer J. B., Sebastiani G., Seim L., Seki Y., Serme A. K., Shapiro D., Sharvadze L., Shaw J. E., Shawa I. T., Shenoy T., Shibolet O., Shimakawa Y., Shubrook J. H., Singh S. P., Sinkala E., Skladany L., Skrypnyk I., Song M. J., Sookoian S., Sridharan K., Stefan N., Stine J. G., Stratakis N., Sheriff D. S., Sundaram S. S., Svegliati-Baroni G., Swain M. G., Tacke F., Taheri S., Tan S. -S., Tapper E. B., Targher G., Tcaciuc E., Thiele M., Tiniakos D., Tolmane I., Torre A., Torres E. A., Treeprasertsuk S., Trenell M., Turcan S., Turcanu A., Valantinas J., van Kleef L. A., Velarde Ruiz Velasco J. A., Vesterhus M., Vilar-Gomez E., Waked I., Wattacheril J., Wedemeyer H., Wilkins F., Willemse J., Wong R. J., Yilmaz Y., Yki-Jarvinen H., Yu M. -L., Yumuk V., Zeybel M., Zheng K. I., and Zheng M. -H.

Abstract

Background & aims: An estimated 38% of adults worldwide have non-alcoholic fatty liver disease (NAFLD). From individual impacts to widespread public health and economic consequences, the implications of this disease are profound. This study aimed to develop an aligned, prioritised fatty liver disease research agenda for the global health community. Methods: Nine co-chairs drafted initial research priorities, subsequently reviewed by 40 core authors and debated during a three-day in-person meeting. Following a Delphi methodology, over two rounds, a large panel (R1 n = 344, R2 n = 288) reviewed the priorities, via Qualtrics XM, indicating agreement using a four-point Likert-scale and providing written feedback. The core group revised the draft priorities between rounds. In R2, panellists also ranked the priorities within six domains: epidemiology, models of care, treatment and care, education and awareness, patient and community perspectives, and leadership and public health policy. Results: The consensus-built fatty liver disease research agenda encompasses 28 priorities. The mean percentage of ‘agree’ responses increased from 78.3 in R1 to 81.1 in R2. Five priorities received unanimous combined agreement (‘agree’ + ‘somewhat agree’); the remaining 23 priorities had >90% combined agreement. While all but one of the priorities exhibited at least a super-majority of agreement (>66.7% ‘agree’), 13 priorities had [removed]90% combined agreement. Conclusions: Adopting this multidisciplinary consensus-built research priorities agenda can deliver a step-change in addressing fatty liver disease, mitigating against its individual and societal harms and proactively altering its natural history through prevention, identification, treatment, and care. This agenda should catalyse the global health community's efforts to advance and accelerate responses to this widespread and fast-growing public health threat. Impact and implications: An estimated 38% of adults and 13% o

Published
2023

18. Beyond Culturing Approach for Accessing Hydrocarbon-Degrading Microbes in Petroleum Hydrocarbon Polluted Soils: A Perspective

Author

Ibrahim I. Hussein, Habiba I. Atta, Salihu Ibrahim, and Lazarus J. Goje

Abstract

Petroleum hydrocarbon-polluted environments contain massive diversity of microbes capable of transforming or reducing hydrocarbon concentrations, and this has consequently led to an interest in the cultivation screening for microbial potentials to remediate petroleum hydrocarbon-polluted lands. Conversely, the reliance singly on culturing approach for the discovery of various hydrocarbon-degrading bacteria without probing for its hydrocarbon degradative capabilities has now become rampant in some research communities, and in most cases may not be justifiable. Besides, vast microbial communities with hydrocarbon-degrading potentials are eluded with the conventional method. Opportunely, the advent of culture-independent approaches such as molecular techniques and next-generation sequencing (NGS) technology has shifted the paradigm of research, now focusing on contemporary and advanced trending ways to discover the uncultivable microbial communities and assess their functional roles in the environment. To ascertain that microorganisms cultured from polluted environmental samples are factual hydrocarbon-degrading strains, a microbiologist needs to investigate beyond just culturing and probe further for the hydrocarbon-degrading prowess by choosing from various arrays of the culture-independent approaches. Consequently, this counters the questionability of only the cultivation approach and explores the vast recompenses of the latter approach when coupled. This perspective review exposes the huge gap in the application of the lone conventional culturing technique for retrieving the uncultured communities, particularly the hydrocarbon-degrading group while hinting at complementary alternatives for improved research and scientific evidence-driven and justifiable study inference.

Published
2022
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19. Prealbumin, mortality, and cause-specific hospitalization in hemodialysis patients.

Author

Chertow, Glenn M, Goldstein-Fuchs, D Jordi, Lazarus, J Michael, and Kaysen, George A

Subjects
Aged, Arteriovenous Shunt, Surgical, Biological Markers, Female, Hospitalization, Humans, Infection, Kidney Failure, Chronic, Male, Middle Aged, Prealbumin, Renal Dialysis, Research Support, N.I.H., Extramural, Risk Factors, Serum Albumin
Abstract

Background. Prealbumin (transthyretin) is a hepatic secretory protein thought to be important in the evaluation of nutritional deficiency and nutrition support. Prior studies have suggested that the serum prealbumin concentration is independently associated with mortality in hemodialysis patients, even with adjustment for serum albumin and other nutritional parameters. Methods. To determine whether prealbumin was independently associated with mortality and morbidity (cause-specific hospitalization) in hemodialysis patients, we analyzed data on 7815 hemodialysis patients with at least one determination of serum prealbumin during the last three months of 1997. Unadjusted, case mix-adjusted, and multivariable-adjusted relative risks of death were calculated for categories of serum prealbumin using proportional hazards regression. We also determined whether the prealbumin concentration was associated with all-cause, cardiovascular, infection-related, and vascular access-related hospitalization. Results. The relative risk (RR) of death was inversely related to the serum prealbumin concentration. Relative to prealbumin >= 40 mg/dL, the adjusted RRs of death were 2.41, 1.85, 1.49, and 1.23 for prealbumin < 15, 15-20, 20-25, and 25-30 mg/dL, respectively. The adjusted RRs of hospitalization due to infection were 2.97, 1.95, 1.81, and 1.61 for prealbumin < 15, 15-20, 20-25, and 25-30 mg/dL, respectively. The adjusted RRs of vascular access-related hospitalization were 0.48, 0.52, 0.58, and 0.71 for prealbumin < 15, 15-20, 20-25, and 25-30 mg/dL, respectively. While serum albumin was strongly associated with mortality and all-cause hospitalization, it was not associated with hospitalization due to infection, and lower levels were associated with higher rather than lower rates of vascular access-related hospitalization. Conclusion. In hemodialysis patients, lower prealbumin concentrations were associated with mortality and hospitalization due to infection, independent of serum albumin and other clinical characteristics. Higher prealbumin concentrations were associated with vascular access-related hospitalization. In light of these findings, more intensive study into the determinants and biological actions of prealbumin (transthyretin) in end-stage renal disease is warranted.

Published
2005

20. Quality of Care in Profit vs Not-For-Profit Dialysis Centers—Reply

Author

Bosch, Juan, Hakim, Raymond M, Lazarus, J Michael, and McAllister, Charles J

Subjects
Hemodialysis Units, Hospital, Hospital Mortality, Hospitals, Proprietary, Hospitals, Voluntary, Humans, Quality Indicators, Health Care, Renal Dialysis, United States, Medical and Health Sciences, General & Internal Medicine
Published
2003

24. Global, regional, and national burden of hepatitis B, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Author

Sheena, B, Hiebert, L, Han, H, Ippolito, H, Abbasi-Kangevari, M, Abbasi-Kangevari, Z, Abbastabar, H, Abdoli, A, Abubaker Ali, H, Adane, M, Adegboye, O, Adnani, Q, Advani, S, Afzal, M, Afzal, S, Aghaie Meybodi, M, Ahadinezhad, B, Ahinkorah, B, Ahmad, S, Ahmad, T, Ahmadi, S, Ahmed, H, Ahmed, M, Rashid, T, Akalu, G, Aklilu, A, Akram, T, Al Hamad, H, Alahdab, F, Alem, A, Alem, D, Alhalaiqa, F, Alhassan, R, Ali, L, Ali, M, Alimohamadi, Y, Alipour, V, Alkhayyat, M, Almustanyir, S, Al-Raddadi, R, Altawalah, H, Amini, S, Amu, H, Ancuceanu, R, Andrei, C, Andrei, T, Anoushiravani, A, Ansar, A, Anyasodor, A, Arabloo, J, Arab-Zozani, M, Argaw, A, Argaw, Z, Arshad, M, Artamonov, A, Ashraf, T, Atlaw, D, Ausloos, F, Ausloos, M, Azadnajafabad, S, Azangou-Khyavy, M, Azari Jafari, A, Azarian, G, Bagheri, S, Bahadory, S, Baig, A, Banach, M, Barati, N, Barrow, A, Batiha, A, Bejarano Ramirez, D, Belgaumi, U, Berhie, A, Bhagat, D, Bhardwaj, N, Bhardwaj, P, Bhattacharyya, K, Bhojaraja, V, Bijani, A, Biondi, A, Bodicha, B, Bojia, H, Boloor, A, Bosetti, C, Braithwaite, D, Briko, N, Butt, Z, Camera, L, Chakinala, R, Chakraborty, P, Charan, J, Chen, S, Choi, J, Choudhari, S, Chowdhury, F, Chu, D, Chung, S, Cortesi, P, Cowie, B, Culbreth, G, Dadras, O, Dai, X, Dandona, L, Dandona, R, De La Hoz, F, Debela, S, Dedefo, M, Demeke, F, Demie, T, Demissie, G, Derbew Molla, M, Desta, A, Dhamnetiya, D, Dhimal, M, Didehdar, M, Doan, L, Dorostkar, F, Drake, T, Eghbalian, F, Ekholuenetale, M, El Sayed, I, El Sayed Zaki, M, Elhadi, M, Elmonem, M, Elsharkawy, A, Enany, S, Enyew, D, Erkhembayar, R, Eskandarieh, S, Esmaeilzadeh, F, Ezzikouri, S, Farrokhpour, H, Fetensa, G, Fischer, F, Foroutan, M, Gad, M, Gaidhane, A, Gaidhane, S, Galles, N, Gallus, S, Gebremeskel, T, Gebreyohannes, E, Ghadiri, K, Ghaffari, K, Ghafourifard, M, Ghamari, S, Ghashghaee, A, Gholami, A, Gholizadeh, A, Gilani, A, Goel, A, Golechha, M, Goleij, P, Golinelli, D, Gorini, G, Goshu, Y, Griswold, M, Gubari, M, Gupta, B, Gupta, S, Gupta, V, Haddadi, R, Halwani, R, Hamid, S, Hamidi, S, Hanif, A, Haque, S, Harapan, H, Hargono, A, Hariri, S, Hasaballah, A, Hasan, S, Hassanipour, S, Hassankhani, H, Hay, S, Hayat, K, Heidari, G, Herteliu, C, Heyi, D, Hezam, K, Holla, R, Hosseini, M, Hosseinzadeh, M, Hostiuc, M, Househ, M, Huang, J, Hussein, N, Iavicoli, I, Ibitoye, S, Ilesanmi, O, Ilic, I, Ilic, M, Irham, L, Islam, J, Ismail, N, Jacobsen, K, Jadidi-Niaragh, F, Javadi Mamaghani, A, Jayaram, S, Jayawardena, R, Jebai, R, Jha, R, Joseph, N, Joukar, F, Kaambwa, B, Kabir, A, Kabir, Z, Kalhor, R, Kandel, H, Kanko, T, Kantar, R, Karaye, I, Kassa, B, Kemp Bohan, P, Keykhaei, M, Khader, Y, Khajuria, H, Khan, G, Khan, I, Khan, J, Khan, M, Khanali, J, Khater, A, Khatib, M, Khodadost, M, Khoja, A, Khosravizadeh, O, Khubchandani, J, Kim, G, Kim, H, Kim, M, Kim, Y, Kocarnik, J, Kolahi, A, Koteeswaran, R, Kumar, G, La Vecchia, C, Lal, D, Landires, I, Lasrado, S, Lazarus, J, Ledda, C, Lee, D, Lee, S, Lee, Y, Levi, M, Li, J, Lim, S, Lobo, S, Lopukhov, P, Loureiro, J, Maclachlan, J, Magdy Abd El Razek, H, Magdy Abd El Razek, M, Majeed, A, Makki, A, Malekpour, M, Malekzadeh, R, Malik, A, Mansour-Ghanaei, F, Mansournia, M, Martins-Melo, F, Matthews, P, Mendoza, W, Menezes, R, Meretoja, T, Mersha, A, Mestrovic, T, Miller, T, Minh, L, Mirica, A, Mirmoeeni, S, Mirrakhimov, E, Misra, S, Mithra, P, Moazen, B, Mohamadkhani, A, Mohammadi, M, Mohammed, S, Moka, N, Mokdad, A, Moludi, J, Momtazmanesh, S, Monasta, L, Moradi, G, Moradzadeh, M, Moradzadeh, R, Moraga, P, Mostafavi, E, Mubarik, S, Muniyandi, M, Murray, C, Naghavi, M, Naimzada, M, Narasimha Swamy, S, Natto, Z, Nayak, B, Nazari, J, Negoi, I, Negru, S, Nejadghaderi, S, Neupane Kandel, S, Nguyen, H, Ngwa, C, Niazi, R, Nnaji, C, Noubiap, J, Nowroozi, A, Nunez-Samudio, V, Oancea, B, Ochir, C, Odukoya, O, Oh, I, Olagunju, A, Olakunde, B, Omar Bali, A, Omer, E, Otstavnov, S, Oumer, B, Padubidri, J, Pana, A, Pandey, A, Park, E, Pashazadeh Kan, F, Patel, U, Paudel, U, Petcu, I, Piracha, Z, Pollok, R, Postma, M, Pourshams, A, Poustchi, H, Rabiee, M, Rabiee, N, Rafiei, A, Rafiei, S, Raghuram, P, Rahman, M, Rahmani, A, Rahmawaty, S, Rajesh, A, Ranasinghe, P, Rao, C, Rao, S, Rashidi, M, Rawaf, D, Rawaf, S, Rawassizadeh, R, Rezaei, N, Rezapour, A, Rezazadeh-Khadem, S, Rodriguez, J, Rwegerera, G, Sabour, S, Saddik, B, Saeb, M, Saeed, U, Sahebkar, A, Saif-Ur-Rahman, K, Salahi, S, Salimzadeh, H, Sampath, C, Samy, A, Sanabria, J, Sanmarchi, F, Santric-Milicevic, M, Sarveazad, A, Sathian, B, Sawhney, M, Seidu, A, Sepanlou, S, Seylani, A, Shahabi, S, Shaikh, M, Shaker, E, Shakhmardanov, M, Shannawaz, M, Shenoy, S, Shetty, J, Shetty, P, Shibuya, K, Shin, J, Shobeiri, P, Sibhat, M, Singh, A, Singh, J, Singh, S, Skryabin, V, Skryabina, A, Sohrabpour, A, Song, S, Tabaeian, S, Tadesse, E, Taheri, M, Tampa, M, Tan, K, Tavakoli, A, Tbakhi, A, Tefera, B, Tehrani-Banihashemi, A, Tesfaw, H, Thapar, R, Thavamani, A, Tohidast, S, Tollosa, D, Tosti, M, Tovani-Palone, M, Traini, E, Tran, M, Trihandini, I, Tusa, B, Ullah, I, Vacante, M, Valadan Tahbaz, S, Valdez, P, Varthya, S, Vo, B, Waheed, Y, Weldesenbet, A, Woldemariam, M, Xu, S, Yahyazadeh Jabbari, S, Yaseri, M, Yeshaw, Y, Yigit, V, Yirdaw, B, Yonemoto, N, Yu, C, Yunusa, I, Zahir, M, Zaki, L, Zamani, M, Zamanian, M, Zastrozhin, M, Vos, T, Ward, J, Dirac, M, Sheena B. S., Hiebert L., Han H., Ippolito H., Abbasi-Kangevari M., Abbasi-Kangevari Z., Abbastabar H., Abdoli A., Abubaker Ali H., Adane M. M., Adegboye O. A., Adnani Q. E. S., Advani S. M., Afzal M. S., Afzal S., Aghaie Meybodi M., Ahadinezhad B., Ahinkorah B. O., Ahmad S., Ahmad T., Ahmadi S., Ahmed H., Ahmed M. B., Rashid T. A., Akalu G. T., Aklilu A., Akram T., Al Hamad H., Alahdab F., Alem A., Alem D. T., Alhalaiqa F. A. N., Alhassan R. K., Ali L., Ali M. A., Alimohamadi Y., Alipour V., Alkhayyat M., Almustanyir S., Al-Raddadi R. M., Altawalah H., Amini S., Amu H., Ancuceanu R., Andrei C. L., Andrei T., Anoushiravani A., Ansar A., Anyasodor A. E., Arabloo J., Arab-Zozani M., Argaw A. M., Argaw Z. G., Arshad M., Artamonov A. A., Ashraf T., Atlaw D., Ausloos F., Ausloos M., Azadnajafabad S., Azangou-Khyavy M., Azari Jafari A., Azarian G., Bagheri S., Bahadory S., Baig A. A., Banach M., Barati N., Barrow A., Batiha A. -M. M., Bejarano Ramirez D. F., Belgaumi U. I., Berhie A. Y., Bhagat D. S., Bhardwaj N., Bhardwaj P., Bhattacharyya K., Bhojaraja V. S., Bijani A., Biondi A., Bodicha B. B. A., Bojia H. A., Boloor A., Bosetti C., Braithwaite D., Briko N. I., Butt Z. A., Camera L. A., Chakinala R. C., Chakraborty P. A., Charan J., Chen S., Choi J. -Y. J., Choudhari S. G., Chowdhury F. R., Chu D. -T., Chung S. -C., Cortesi P. A., Cowie B. C., Culbreth G. T., Dadras O., Dai X., Dandona L., Dandona R., De La Hoz F. P., Debela S. A., Dedefo M. G., Demeke F. M., Demie T. G. G., Demissie G. D., Derbew Molla M., Desta A. A., Dhamnetiya D., Dhimal M. L., Dhimal M., Didehdar M., Doan L. P., Dorostkar F., Drake T. M., Eghbalian F., Ekholuenetale M., El Sayed I., El Sayed Zaki M., Elhadi M., Elmonem M. A., Elsharkawy A., Enany S., Enyew D. B., Erkhembayar R., Eskandarieh S., Esmaeilzadeh F., Ezzikouri S., Farrokhpour H., Fetensa G., Fischer F., Foroutan M., Gad M. M., Gaidhane A. M., Gaidhane S., Galles N. C., Gallus S., Gebremeskel T. G., Gebreyohannes E. A., Ghadiri K., Ghaffari K., Ghafourifard M., Ghamari S. -H., Ghashghaee A., Gholami A., Gholizadeh A., Gilani A., Goel A., Golechha M., Goleij P., Golinelli D., Gorini G., Goshu Y. A., Griswold M. G., Gubari M. I. M., Gupta B., Gupta S., Gupta V. B., Gupta V. K., Haddadi R., Halwani R., Hamid S. S., Hamidi S., Hanif A., Haque S., Harapan H., Hargono A., Hariri S., Hasaballah A. I., Hasan S. M. M., Hassanipour S., Hassankhani H., Hay S. I., Hayat K., Heidari G., Herteliu C., Heyi D. Z., Hezam K., Holla R., Hosseini M. -S., Hosseini M., Hosseinzadeh M., Hostiuc M., Househ M., Huang J., Hussein N. R., Iavicoli I., Ibitoye S. E., Ilesanmi O. S., Ilic I. M., Ilic M. D., Irham L. M., Islam J. Y., Ismail N. E., Jacobsen K. H., Jadidi-Niaragh F., Javadi Mamaghani A., Jayaram S., Jayawardena R., Jebai R., Jha R. P., Joseph N., Joukar F., Kaambwa B., Kabir A., Kabir Z., Kalhor R., Kandel H., Kanko T. K. T., Kantar R. S., Karaye I. M., Kassa B. G., Kemp Bohan P. M., Keykhaei M., Khader Y. S., Khajuria H., Khan G., Khan I. A., Khan J., Khan M. A., Khanali J., Khater A. M., Khatib M. N., Khodadost M., Khoja A. T., Khosravizadeh O., Khubchandani J., Kim G. R., Kim H., Kim M. S., Kim Y. J., Kocarnik J. M., Kolahi A. -A., Koteeswaran R., Kumar G. A., La Vecchia C., Lal D. K., Landires I., Lasrado S., Lazarus J. V., Ledda C., Lee D. W., Lee S. -W., Lee Y. Y., Levi M., Li J., Lim S. S., Lobo S. W., Lopukhov P. D., Loureiro J. A., MacLachlan J. H., Magdy Abd El Razek H., Magdy Abd El Razek M., Majeed A., Makki A., Malekpour M. -R., Malekzadeh R., Malik A. A., Mansour-Ghanaei F., Mansournia M. A., Martins-Melo F. R., Matthews P. C., Mendoza W., Menezes R. G., Meretoja T. J., Mersha A. G., Mestrovic T., Miller T. R., Minh L. H. N., Mirica A., Mirmoeeni S., Mirrakhimov E. M., Misra S., Mithra P., Moazen B., Mohamadkhani A., Mohammadi M., Mohammed S., Moka N., Mokdad A. H., Moludi J., Momtazmanesh S., Monasta L., Moradi G., Moradzadeh M., Moradzadeh R., Moraga P., Mostafavi E., Mubarik S., Muniyandi M., Murray C. J. L., Naghavi M., Naimzada M. D., Narasimha Swamy S., Natto Z. S., Nayak B. P., Nazari J., Negoi I., Negru S. M., Nejadghaderi S. A., Neupane Kandel S., Nguyen H. L. T., Ngwa C. H., Niazi R. K., Nnaji C. A., Noubiap J. J., Nowroozi A., Nunez-Samudio V., Oancea B., Ochir C., Odukoya O. O., Oh I. -H., Olagunju A. T., Olakunde B. O., Omar Bali A., Omer E., Otstavnov S. S., Oumer B., Padubidri J. R., Pana A., Pandey A., Park E. -C., Pashazadeh Kan F., Patel U. K., Paudel U., Petcu I. -R., Piracha Z. Z., Pollok R. C. G., Postma M. J., Pourshams A., Poustchi H., Rabiee M., Rabiee N., Rafiei A., Rafiei S., Raghuram P. M., Rahman M., Rahmani A. M., Rahmawaty S., Rajesh A., Ranasinghe P., Rao C. R., Rao S. J., Rashidi M., Rashidi M. -M., Rawaf D. L., Rawaf S., Rawassizadeh R., Rezaei N., Rezapour A., Rezazadeh-Khadem S., Rodriguez J. A. B., Rwegerera G. M., Sabour S., Saddik B., Saeb M. R., Saeed U., Sahebkar A., Saif-Ur-Rahman K. M., Salahi S., Salimzadeh H., Sampath C., Samy A. M., Sanabria J., Sanmarchi F., Santric-Milicevic M. M., Sarveazad A., Sathian B., Sawhney M., Seidu A. -A., Sepanlou S. G., Seylani A., Shahabi S., Shaikh M. A., Shaker E., Shakhmardanov M. Z., Shannawaz M., Shenoy S. M., Shetty J. K., Shetty P. H., Shibuya K., Shin J. I., Shobeiri P., Sibhat M. M., Singh A. D., Singh J. A., Singh S., Skryabin V. Y., Skryabina A. A., Sohrabpour A. A., Song S., Tabaeian S. P., Tadesse E. G., Taheri M., Tampa M., Tan K. -K., Tavakoli A., Tbakhi A., Tefera B. N., Tehrani-Banihashemi A., Tesfaw H. M., Thapar R., Thavamani A., Tohidast S. A., Tollosa D. N., Tosti M. E., Tovani-Palone M. R., Traini E., Tran M. T. N., Trihandini I., Tusa B. S., Ullah I., Vacante M., Valadan Tahbaz S., Valdez P. R., Varthya S. B., Vo B., Waheed Y., Weldesenbet A. B., Woldemariam M., Xu S., Yahyazadeh Jabbari S. H., Yaseri M., Yeshaw Y., Yigit V., Yirdaw B. W., Yonemoto N., Yu C., Yunusa I., Zahir M., Zaki L., Zamani M., Zamanian M., Zastrozhin M. S., Vos T., Ward J. W., Dirac M. A., Sheena, B, Hiebert, L, Han, H, Ippolito, H, Abbasi-Kangevari, M, Abbasi-Kangevari, Z, Abbastabar, H, Abdoli, A, Abubaker Ali, H, Adane, M, Adegboye, O, Adnani, Q, Advani, S, Afzal, M, Afzal, S, Aghaie Meybodi, M, Ahadinezhad, B, Ahinkorah, B, Ahmad, S, Ahmad, T, Ahmadi, S, Ahmed, H, Ahmed, M, Rashid, T, Akalu, G, Aklilu, A, Akram, T, Al Hamad, H, Alahdab, F, Alem, A, Alem, D, Alhalaiqa, F, Alhassan, R, Ali, L, Ali, M, Alimohamadi, Y, Alipour, V, Alkhayyat, M, Almustanyir, S, Al-Raddadi, R, Altawalah, H, Amini, S, Amu, H, Ancuceanu, R, Andrei, C, Andrei, T, Anoushiravani, A, Ansar, A, Anyasodor, A, Arabloo, J, Arab-Zozani, M, Argaw, A, Argaw, Z, Arshad, M, Artamonov, A, Ashraf, T, Atlaw, D, Ausloos, F, Ausloos, M, Azadnajafabad, S, Azangou-Khyavy, M, Azari Jafari, A, Azarian, G, Bagheri, S, Bahadory, S, Baig, A, Banach, M, Barati, N, Barrow, A, Batiha, A, Bejarano Ramirez, D, Belgaumi, U, Berhie, A, Bhagat, D, Bhardwaj, N, Bhardwaj, P, Bhattacharyya, K, Bhojaraja, V, Bijani, A, Biondi, A, Bodicha, B, Bojia, H, Boloor, A, Bosetti, C, Braithwaite, D, Briko, N, Butt, Z, Camera, L, Chakinala, R, Chakraborty, P, Charan, J, Chen, S, Choi, J, Choudhari, S, Chowdhury, F, Chu, D, Chung, S, Cortesi, P, Cowie, B, Culbreth, G, Dadras, O, Dai, X, Dandona, L, Dandona, R, De La Hoz, F, Debela, S, Dedefo, M, Demeke, F, Demie, T, Demissie, G, Derbew Molla, M, Desta, A, Dhamnetiya, D, Dhimal, M, Didehdar, M, Doan, L, Dorostkar, F, Drake, T, Eghbalian, F, Ekholuenetale, M, El Sayed, I, El Sayed Zaki, M, Elhadi, M, Elmonem, M, Elsharkawy, A, Enany, S, Enyew, D, Erkhembayar, R, Eskandarieh, S, Esmaeilzadeh, F, Ezzikouri, S, Farrokhpour, H, Fetensa, G, Fischer, F, Foroutan, M, Gad, M, Gaidhane, A, Gaidhane, S, Galles, N, Gallus, S, Gebremeskel, T, Gebreyohannes, E, Ghadiri, K, Ghaffari, K, Ghafourifard, M, Ghamari, S, Ghashghaee, A, Gholami, A, Gholizadeh, A, Gilani, A, Goel, A, Golechha, M, Goleij, P, Golinelli, D, Gorini, G, Goshu, Y, Griswold, M, Gubari, M, Gupta, B, Gupta, S, Gupta, V, Haddadi, R, Halwani, R, Hamid, S, Hamidi, S, Hanif, A, Haque, S, Harapan, H, Hargono, A, Hariri, S, Hasaballah, A, Hasan, S, Hassanipour, S, Hassankhani, H, Hay, S, Hayat, K, Heidari, G, Herteliu, C, Heyi, D, Hezam, K, Holla, R, Hosseini, M, Hosseinzadeh, M, Hostiuc, M, Househ, M, Huang, J, Hussein, N, Iavicoli, I, Ibitoye, S, Ilesanmi, O, Ilic, I, Ilic, M, Irham, L, Islam, J, Ismail, N, Jacobsen, K, Jadidi-Niaragh, F, Javadi Mamaghani, A, Jayaram, S, Jayawardena, R, Jebai, R, Jha, R, Joseph, N, Joukar, F, Kaambwa, B, Kabir, A, Kabir, Z, Kalhor, R, Kandel, H, Kanko, T, Kantar, R, Karaye, I, Kassa, B, Kemp Bohan, P, Keykhaei, M, Khader, Y, Khajuria, H, Khan, G, Khan, I, Khan, J, Khan, M, Khanali, J, Khater, A, Khatib, M, Khodadost, M, Khoja, A, Khosravizadeh, O, Khubchandani, J, Kim, G, Kim, H, Kim, M, Kim, Y, Kocarnik, J, Kolahi, A, Koteeswaran, R, Kumar, G, La Vecchia, C, Lal, D, Landires, I, Lasrado, S, Lazarus, J, Ledda, C, Lee, D, Lee, S, Lee, Y, Levi, M, Li, J, Lim, S, Lobo, S, Lopukhov, P, Loureiro, J, Maclachlan, J, Magdy Abd El Razek, H, Magdy Abd El Razek, M, Majeed, A, Makki, A, Malekpour, M, Malekzadeh, R, Malik, A, Mansour-Ghanaei, F, Mansournia, M, Martins-Melo, F, Matthews, P, Mendoza, W, Menezes, R, Meretoja, T, Mersha, A, Mestrovic, T, Miller, T, Minh, L, Mirica, A, Mirmoeeni, S, Mirrakhimov, E, Misra, S, Mithra, P, Moazen, B, Mohamadkhani, A, Mohammadi, M, Mohammed, S, Moka, N, Mokdad, A, Moludi, J, Momtazmanesh, S, Monasta, L, Moradi, G, Moradzadeh, M, Moradzadeh, R, Moraga, P, Mostafavi, E, Mubarik, S, Muniyandi, M, Murray, C, Naghavi, M, Naimzada, M, Narasimha Swamy, S, Natto, Z, Nayak, B, Nazari, J, Negoi, I, Negru, S, Nejadghaderi, S, Neupane Kandel, S, Nguyen, H, Ngwa, C, Niazi, R, Nnaji, C, Noubiap, J, Nowroozi, A, Nunez-Samudio, V, Oancea, B, Ochir, C, Odukoya, O, Oh, I, Olagunju, A, Olakunde, B, Omar Bali, A, Omer, E, Otstavnov, S, Oumer, B, Padubidri, J, Pana, A, Pandey, A, Park, E, Pashazadeh Kan, F, Patel, U, Paudel, U, Petcu, I, Piracha, Z, Pollok, R, Postma, M, Pourshams, A, Poustchi, H, Rabiee, M, Rabiee, N, Rafiei, A, Rafiei, S, Raghuram, P, Rahman, M, Rahmani, A, Rahmawaty, S, Rajesh, A, Ranasinghe, P, Rao, C, Rao, S, Rashidi, M, Rawaf, D, Rawaf, S, Rawassizadeh, R, Rezaei, N, Rezapour, A, Rezazadeh-Khadem, S, Rodriguez, J, Rwegerera, G, Sabour, S, Saddik, B, Saeb, M, Saeed, U, Sahebkar, A, Saif-Ur-Rahman, K, Salahi, S, Salimzadeh, H, Sampath, C, Samy, A, Sanabria, J, Sanmarchi, F, Santric-Milicevic, M, Sarveazad, A, Sathian, B, Sawhney, M, Seidu, A, Sepanlou, S, Seylani, A, Shahabi, S, Shaikh, M, Shaker, E, Shakhmardanov, M, Shannawaz, M, Shenoy, S, Shetty, J, Shetty, P, Shibuya, K, Shin, J, Shobeiri, P, Sibhat, M, Singh, A, Singh, J, Singh, S, Skryabin, V, Skryabina, A, Sohrabpour, A, Song, S, Tabaeian, S, Tadesse, E, Taheri, M, Tampa, M, Tan, K, Tavakoli, A, Tbakhi, A, Tefera, B, Tehrani-Banihashemi, A, Tesfaw, H, Thapar, R, Thavamani, A, Tohidast, S, Tollosa, D, Tosti, M, Tovani-Palone, M, Traini, E, Tran, M, Trihandini, I, Tusa, B, Ullah, I, Vacante, M, Valadan Tahbaz, S, Valdez, P, Varthya, S, Vo, B, Waheed, Y, Weldesenbet, A, Woldemariam, M, Xu, S, Yahyazadeh Jabbari, S, Yaseri, M, Yeshaw, Y, Yigit, V, Yirdaw, B, Yonemoto, N, Yu, C, Yunusa, I, Zahir, M, Zaki, L, Zamani, M, Zamanian, M, Zastrozhin, M, Vos, T, Ward, J, Dirac, M, Sheena B. S., Hiebert L., Han H., Ippolito H., Abbasi-Kangevari M., Abbasi-Kangevari Z., Abbastabar H., Abdoli A., Abubaker Ali H., Adane M. M., Adegboye O. A., Adnani Q. E. S., Advani S. M., Afzal M. S., Afzal S., Aghaie Meybodi M., Ahadinezhad B., Ahinkorah B. O., Ahmad S., Ahmad T., Ahmadi S., Ahmed H., Ahmed M. B., Rashid T. A., Akalu G. T., Aklilu A., Akram T., Al Hamad H., Alahdab F., Alem A., Alem D. T., Alhalaiqa F. A. N., Alhassan R. K., Ali L., Ali M. A., Alimohamadi Y., Alipour V., Alkhayyat M., Almustanyir S., Al-Raddadi R. M., Altawalah H., Amini S., Amu H., Ancuceanu R., Andrei C. L., Andrei T., Anoushiravani A., Ansar A., Anyasodor A. E., Arabloo J., Arab-Zozani M., Argaw A. M., Argaw Z. G., Arshad M., Artamonov A. A., Ashraf T., Atlaw D., Ausloos F., Ausloos M., Azadnajafabad S., Azangou-Khyavy M., Azari Jafari A., Azarian G., Bagheri S., Bahadory S., Baig A. A., Banach M., Barati N., Barrow A., Batiha A. -M. M., Bejarano Ramirez D. F., Belgaumi U. I., Berhie A. Y., Bhagat D. S., Bhardwaj N., Bhardwaj P., Bhattacharyya K., Bhojaraja V. S., Bijani A., Biondi A., Bodicha B. B. A., Bojia H. A., Boloor A., Bosetti C., Braithwaite D., Briko N. I., Butt Z. A., Camera L. A., Chakinala R. C., Chakraborty P. A., Charan J., Chen S., Choi J. -Y. J., Choudhari S. G., Chowdhury F. R., Chu D. -T., Chung S. -C., Cortesi P. A., Cowie B. C., Culbreth G. T., Dadras O., Dai X., Dandona L., Dandona R., De La Hoz F. P., Debela S. A., Dedefo M. G., Demeke F. M., Demie T. G. G., Demissie G. D., Derbew Molla M., Desta A. A., Dhamnetiya D., Dhimal M. L., Dhimal M., Didehdar M., Doan L. P., Dorostkar F., Drake T. M., Eghbalian F., Ekholuenetale M., El Sayed I., El Sayed Zaki M., Elhadi M., Elmonem M. A., Elsharkawy A., Enany S., Enyew D. B., Erkhembayar R., Eskandarieh S., Esmaeilzadeh F., Ezzikouri S., Farrokhpour H., Fetensa G., Fischer F., Foroutan M., Gad M. M., Gaidhane A. M., Gaidhane S., Galles N. C., Gallus S., Gebremeskel T. G., Gebreyohannes E. A., Ghadiri K., Ghaffari K., Ghafourifard M., Ghamari S. -H., Ghashghaee A., Gholami A., Gholizadeh A., Gilani A., Goel A., Golechha M., Goleij P., Golinelli D., Gorini G., Goshu Y. A., Griswold M. G., Gubari M. I. M., Gupta B., Gupta S., Gupta V. B., Gupta V. K., Haddadi R., Halwani R., Hamid S. S., Hamidi S., Hanif A., Haque S., Harapan H., Hargono A., Hariri S., Hasaballah A. I., Hasan S. M. M., Hassanipour S., Hassankhani H., Hay S. I., Hayat K., Heidari G., Herteliu C., Heyi D. Z., Hezam K., Holla R., Hosseini M. -S., Hosseini M., Hosseinzadeh M., Hostiuc M., Househ M., Huang J., Hussein N. R., Iavicoli I., Ibitoye S. E., Ilesanmi O. S., Ilic I. M., Ilic M. D., Irham L. M., Islam J. Y., Ismail N. E., Jacobsen K. H., Jadidi-Niaragh F., Javadi Mamaghani A., Jayaram S., Jayawardena R., Jebai R., Jha R. P., Joseph N., Joukar F., Kaambwa B., Kabir A., Kabir Z., Kalhor R., Kandel H., Kanko T. K. T., Kantar R. S., Karaye I. M., Kassa B. G., Kemp Bohan P. M., Keykhaei M., Khader Y. S., Khajuria H., Khan G., Khan I. A., Khan J., Khan M. A., Khanali J., Khater A. M., Khatib M. N., Khodadost M., Khoja A. T., Khosravizadeh O., Khubchandani J., Kim G. R., Kim H., Kim M. S., Kim Y. J., Kocarnik J. M., Kolahi A. -A., Koteeswaran R., Kumar G. A., La Vecchia C., Lal D. K., Landires I., Lasrado S., Lazarus J. V., Ledda C., Lee D. W., Lee S. -W., Lee Y. Y., Levi M., Li J., Lim S. S., Lobo S. W., Lopukhov P. D., Loureiro J. A., MacLachlan J. H., Magdy Abd El Razek H., Magdy Abd El Razek M., Majeed A., Makki A., Malekpour M. -R., Malekzadeh R., Malik A. A., Mansour-Ghanaei F., Mansournia M. A., Martins-Melo F. R., Matthews P. C., Mendoza W., Menezes R. G., Meretoja T. J., Mersha A. G., Mestrovic T., Miller T. R., Minh L. H. N., Mirica A., Mirmoeeni S., Mirrakhimov E. M., Misra S., Mithra P., Moazen B., Mohamadkhani A., Mohammadi M., Mohammed S., Moka N., Mokdad A. H., Moludi J., Momtazmanesh S., Monasta L., Moradi G., Moradzadeh M., Moradzadeh R., Moraga P., Mostafavi E., Mubarik S., Muniyandi M., Murray C. J. L., Naghavi M., Naimzada M. D., Narasimha Swamy S., Natto Z. S., Nayak B. P., Nazari J., Negoi I., Negru S. M., Nejadghaderi S. A., Neupane Kandel S., Nguyen H. L. T., Ngwa C. H., Niazi R. K., Nnaji C. A., Noubiap J. J., Nowroozi A., Nunez-Samudio V., Oancea B., Ochir C., Odukoya O. O., Oh I. -H., Olagunju A. T., Olakunde B. O., Omar Bali A., Omer E., Otstavnov S. S., Oumer B., Padubidri J. R., Pana A., Pandey A., Park E. -C., Pashazadeh Kan F., Patel U. K., Paudel U., Petcu I. -R., Piracha Z. Z., Pollok R. C. G., Postma M. J., Pourshams A., Poustchi H., Rabiee M., Rabiee N., Rafiei A., Rafiei S., Raghuram P. M., Rahman M., Rahmani A. M., Rahmawaty S., Rajesh A., Ranasinghe P., Rao C. R., Rao S. J., Rashidi M., Rashidi M. -M., Rawaf D. L., Rawaf S., Rawassizadeh R., Rezaei N., Rezapour A., Rezazadeh-Khadem S., Rodriguez J. A. B., Rwegerera G. M., Sabour S., Saddik B., Saeb M. R., Saeed U., Sahebkar A., Saif-Ur-Rahman K. M., Salahi S., Salimzadeh H., Sampath C., Samy A. M., Sanabria J., Sanmarchi F., Santric-Milicevic M. M., Sarveazad A., Sathian B., Sawhney M., Seidu A. -A., Sepanlou S. G., Seylani A., Shahabi S., Shaikh M. A., Shaker E., Shakhmardanov M. Z., Shannawaz M., Shenoy S. M., Shetty J. K., Shetty P. H., Shibuya K., Shin J. I., Shobeiri P., Sibhat M. M., Singh A. D., Singh J. A., Singh S., Skryabin V. Y., Skryabina A. A., Sohrabpour A. A., Song S., Tabaeian S. P., Tadesse E. G., Taheri M., Tampa M., Tan K. -K., Tavakoli A., Tbakhi A., Tefera B. N., Tehrani-Banihashemi A., Tesfaw H. M., Thapar R., Thavamani A., Tohidast S. A., Tollosa D. N., Tosti M. E., Tovani-Palone M. R., Traini E., Tran M. T. N., Trihandini I., Tusa B. S., Ullah I., Vacante M., Valadan Tahbaz S., Valdez P. R., Varthya S. B., Vo B., Waheed Y., Weldesenbet A. B., Woldemariam M., Xu S., Yahyazadeh Jabbari S. H., Yaseri M., Yeshaw Y., Yigit V., Yirdaw B. W., Yonemoto N., Yu C., Yunusa I., Zahir M., Zaki L., Zamani M., Zamanian M., Zastrozhin M. S., Vos T., Ward J. W., and Dirac M. A.

Abstract

Background: Combating viral hepatitis is part of the UN Sustainable Development Goals (SDGs), and WHO has put forth hepatitis B elimination targets in its Global Health Sector Strategy on Viral Hepatitis (WHO-GHSS) and Interim Guidance for Country Validation of Viral Hepatitis Elimination (WHO Interim Guidance). We estimated the global, regional, and national prevalence of hepatitis B virus (HBV), as well as mortality and disability-adjusted life-years (DALYs) due to HBV, as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. This included estimates for 194 WHO member states, for which we compared our estimates to WHO elimination targets. Methods: The primary data sources were population-based serosurveys, claims and hospital discharges, cancer registries, vital registration systems, and published case series. We estimated chronic HBV infection and the burden of HBV-related diseases, defined as an aggregate of cirrhosis due to hepatitis B, liver cancer due to hepatitis B, and acute hepatitis B. We used DisMod-MR 2.1, a Bayesian mixed-effects meta-regression tool, to estimate the prevalence of chronic HBV infection, cirrhosis, and aetiological proportions of cirrhosis. We used mortality-to-incidence ratios modelled with spatiotemporal Gaussian process regression to estimate the incidence of liver cancer. We used the Cause of Death Ensemble modelling (CODEm) model, a tool that selects models and covariates on the basis of out-of-sample performance, to estimate mortality due to cirrhosis, liver cancer, and acute hepatitis B. Findings: In 2019, the estimated global, all-age prevalence of chronic HBV infection was 4·1% (95% uncertainty interval [UI] 3·7 to 4·5), corresponding to 316 million (284 to 351) infected people. There was a 31·3% (29·0 to 33·9) decline in all-age prevalence between 1990 and 2019, with a more marked decline of 76·8% (76·2 to 77·5) in prevalence in children younger than 5 years. HBV-related diseases resulted in 555 0

Published
2022

25. VIRAL DETECTION IN TICKS AND THE LEVEL OF TICKS’ INFESTATIONS AMONGST SMALL RUMINANTS IN MAIDUGURI, BORNO STATE

Author

PETER E. GHAMBA, LAZARUS J. GOJE, and AISHATU B. SHERIFF

Abstract

Ticks were the first arthropods to be established as vectors of pathogens and are currently recognized, along with mosquitoes, as the main arthropod vectors of disease agents to humans and domestic animals globally due to increased incidences of tick-borne diseases (TBDs) the world over. They are responsible for the transmission of many viral diseases to humans and domestic animals. Therefore, ticks infection and infestation results in great economic losses to resource-poor farming communities, especially in tropical and subtropical regions, including Nigeria, where approximately 80% of the world’s cattle population is raised. The current study is aimed to study the distribution, composition and abundance of ticks in Maiduguri, Borno State. Adult ticks were collected from 350 freshly butchered small ruminants (sheep and goats) from three locations within Maiduguri metropolis namely:Kasuwa shanu, Bulumkutu, and Maiduguri Central Abattoir. These were identified using taxonomy identification keys in to three species, Rhipicephalus, Amblyomma and Hyalomma, using stereomicroscope for each of the locations. They were crushed using bullet blender after the addition of glass beads and centrifuged. The supernatant from the crushed samples was used for viral detection by inoculating it on to two cell lines, Baby Hamster Kidney (BHK) and African Monkey Kidney (Vero E6), and were observed for cytopathic effects daily for a period of ten (10) days. The results showed a high level of ticks’ infestation amongst small ruminants in the study locations. Kasuwan Shanu has the highest distribution of ticks amongst sheep, followed by Maiduguri Central Abattoir while Bulumkutu has the least. More also, Kasuwan Shanu has the highest distribution of ticks amongst goats, followed by Bulumkutu while Maiduguri Central Abbatoir has the least. The three species of ticks investigated were found to comprise of either male or female or both in the different locations, and either of the two sexes is involved in the infestation. The results also showed the presence of virus in some of the tick samples isolated from the small ruminants andinoculated on to the cell lines due to the observed cytopathic effects. It is concluded that there is high level of ticks’ infestation among small ruminants in Maiduguri metropolis and a threat of viral disease transmission to humans and other animals.

Published
2022
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26. Versions of Radicality, 1969/1970. Farocki, Meins, Straschek

Author

Böckler, Ursula, Lazarus, Julia, Weltz-Rombach, Alexandra, Böckler, U ( Ursula ), Lazarus, J ( Julia ), Weltz-Rombach, A ( Alexandra ), Pantenburg, Volker; https://orcid.org/0000-0002-4303-7677, Böckler, Ursula, Lazarus, Julia, Weltz-Rombach, Alexandra, Böckler, U ( Ursula ), Lazarus, J ( Julia ), Weltz-Rombach, A ( Alexandra ), and Pantenburg, Volker; https://orcid.org/0000-0002-4303-7677

Published
2023

29. Papillary renal cell carcinoma presenting as a renal abscess

Author

John, J, Locketz, M, Lazarus, J, and Sinha, S

Subjects
urologic and male genital diseases, neoplasms, female genital diseases and pregnancy complications
Abstract

Renal cell carcinoma (RCC), a highly aggressive and lethal urological malignancy, has a wide variation of signs and symptoms. We report a rare case of papillary RCC (pRCC), presenting as a renal abscess. The knowledge of this association between RCC and a renal abscess is critical to prevent misdiagnosis and/or delayed treatment especially in the elderly and immunocompromised patients.

Published
2023

36. Hepatitis C: The beginning of the end—key elements for successful European and national strategies to eliminate HCV in Europe

Author

Papatheodoridis, G. V., Hatzakis, A., Cholongitas, E., Baptista‐Leite, R., Baskozos, I., Chhatwal, J., Colombo, M., Cortez‐Pinto, H., Craxi, A., Goldberg, D., Gore, C., Kautz, A., Lazarus, J. V., Mendão, L., Peck‐Radosavljevic, M., Razavi, H., Schatz, E., Tözün, N., van Damme, P., Wedemeyer, H., Yazdanpanah, Y., Zuure, F., and Manns, M. P.

Published
2018
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41. Postpartum thyroiditis

Author

Lazarus, J. H., Premawardhana, L. D. K. E., Parkes, A. B., Bird, Graham, editor, Whaley, Keith, editor, and Weetman, A. P., editor

Published
1998
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44. Global, regional, and national burden of hepatitis B, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019

Author

Sheena, BS, Hiebert, L, Han, H, Ippolito, H, Abbasi-Kangevari, M, Abbasi-Kangevari, Z, Abbastabar, H, Abdoli, A, Ali, HA, Adane, MM, Adegboye, OA, Adnani, QES, Advani, SM, Afzal, MS, Afzal, S, Meybodi, MA, Ahadinezhad, B, Ahinkorah, BO, Ahmad, S, Ahmad, T, Ahmadi, S, Ahmed, H, Ahmed, MB, Rashid, TA, Akalu, GT, Aklilu, A, Akram, T, Al Hamad, H, Alahdab, F, Alem, AZ, Alem, DT, Alhalaiqa, FAN, Alhassan, RK, Ali, L, Ali, MA, Alimohamadi, Y, Alipour, V, Alkhayyat, M, Almustanyir, S, Al-Raddadi, RM, Altawalah, H, Amini, S, Amu, H, Ancuceanu, R, Andrei, CL, Andrei, T, Anoushiravani, A, Ansar, A, Anyasodor, AE, Arabloo, J, Arab-Zozani, M, Argaw, AM, Argaw, ZG, Arshad, M, Artamonov, AA, Ashraf, T, Atlaw, D, Ausloos, F, Ausloos, M, Azadnajafabad, S, Azangou-Khyavy, M, Jafari, AA, Azarian, G, Bagheri, S, Bahadory, S, Baig, AA, Banach, M, Barati, N, Barrow, A, Batiha, A-MM, Ramirez, DFB, Belgaumi, UI, Berhie, AY, Bhagat, DS, Bhardwaj, N, Bhardwaj, P, Bhattacharyya, K, Bhojaraja, VS, Bijani, A, Biondi, A, Bodicha, BBA, Bojia, HA, Boloor, A, Bosetti, C, Braithwaite, D, Briko, NI, Butt, ZA, Camera, LA, Chakinala, RC, Chakraborty, PA, Charan, J, Chen, S, Choi, J-YJ, Choudhari, SG, Chowdhury, FR, Chu, D-T, Chung, S-C, Cortesi, PA, Cowie, BC, Culbreth, GT, Dadras, O, Dai, X, Dandona, L, Dandona, R, De la Hoz, FP, Debela, SA, Dedefo, MG, Demeke, FM, Demie, TGG, Demissie, GD, Molla, MD, Desta, AA, Dhamnetiya, D, Dhimal, ML, Dhimal, M, Didehdar, M, Doan, LP, Dorostkar, F, Drake, TM, Eghbalian, F, Ekholuenetale, M, El Sayed, I, Zaki, MES, Elhadi, M, Elmonem, MA, Elsharkawy, A, Enany, S, Enyew, DB, Erkhembayar, R, Eskandarieh, S, Esmaeilzadeh, F, Ezzikouri, S, Farrokhpour, H, Fetensa, G, Fischer, F, Foroutan, M, Gad, MM, Gaidhane, AM, Gaidhane, S, Galles, NC, Gallus, S, Gebremeskel, TG, Gebreyohannes, EA, Ghadiri, K, Ghaffari, K, Ghafourifard, M, Ghamari, S-H, Ghashghaee, A, Gholami, A, Gholizadeh, A, Gilani, A, Goel, A, Golechha, M, Goleij, P, Golinelli, D, Gorini, G, Goshu, YA, Griswold, MG, Gubari, MIM, Gupta, B, Gupta, S, Gupta, VB, Gupta, VK, Haddadi, R, Halwani, R, Hamid, SS, Hamidi, S, Hanif, A, Haque, S, Harapan, H, Hargono, A, Hariri, S, Hasaballah, A, Hasan, SMM, Hassanipour, S, Hassankhani, H, Hay, S, Hayat, K, Heidari, G, Herteliu, C, Heyi, DZ, Hezam, K, Holla, R, Hosseini, M-S, Hosseini, M, Hosseinzadeh, M, Hostiuc, M, Househ, M, Huang, J, Hussein, NR, Iavicoli, I, Ibitoye, SE, Ilesanmi, OS, Ilic, IM, Ilic, MD, Irham, LM, Islam, JY, Ismail, NE, Jacobsen, KH, Jadidi-Niaragh, F, Mamaghani, AJ, Jayaram, S, Jayawardena, R, Jebai, R, Jha, RP, Joseph, N, Joukar, F, Kaambwa, B, Kabir, A, Kabir, Z, Kalhor, R, Kandel, H, Kanko, TKT, Kantar, RS, Karaye, IM, Kassa, BG, Bohan, PMK, Keykhaei, M, Khader, YS, Khajuria, H, Khan, G, Khan, IA, Khan, J, Ab Khan, M, Khanali, J, Khater, AM, Khatib, MN, Khodadost, M, Khoja, AT, Khosravizadeh, O, Khubchandani, J, Kim, GR, Kim, H, Kim, MS, Kim, YJ, Kocarnik, JM, Kolahi, A-A, Koteeswaran, R, Kumar, GA, La Vecchia, C, Lal, DK, Landires, I, Lasrado, S, Lazarus, J, Ledda, C, Lee, DW, Lee, S-W, Lee, YY, Levi, M, Li, J, Lim, SS, Lobo, SW, Lopukhov, PD, Loureiro, JA, MacLachlan, JH, Razek, HMAE, Razek, MMAE, Majeed, A, Makki, A, Malekpour, M-R, Malekzadeh, R, Malik, AA, Mansour-Ghanaei, F, Mansournia, MA, Martins-Melo, FR, Matthews, PC, Mendoza, W, Menezes, RG, Meretoja, TJ, Mersha, AG, Mestrovic, T, Miller, TR, Minh, LHN, Mirica, A, Mirmoeeni, S, Mirrakhimov, EM, Misra, S, Mithra, P, Moazen, B, Mohamadkhani, A, Mohammadi, M, Mohammed, S, Moka, N, Mokdad, AH, Moludi, J, Momtazmanesh, S, Monasta, L, Moradi, G, Moradzadeh, M, Moradzadeh, R, Moraga, P, Mostafavi, E, Mubarik, S, Muniyandi, M, Murray, CJL, Naghavi, M, Naimzada, MD, Swamy, SN, Natto, ZS, Nayak, BP, Nazari, J, Negoi, I, Negru, SM, Nejadghaderi, SA, Kandel, SN, Nguyen, HLT, Ngwa, CH, Niazi, RK, Nnaji, CA, Noubiap, JJ, Nowroozi, A, Nunez-Samudio, V, Oancea, B, Ochir, C, Odukoya, OO, Oh, I-H, Olagunju, AT, Olakunde, BO, Bali, AO, Omer, E, Otstavnov, SS, Oumer, B, Padubidri, JR, Pana, A, Pandey, A, Park, E-C, Kan, FP, Patel, UK, Paudel, U, Petcu, I-R, Piracha, ZZ, Pollok, RCG, Postma, MJ, Pourshams, A, Poustchi, H, Rabiee, M, Rabiee, N, Rafiei, A, Rafiei, S, Raghuram, PM, Rahman, M, Rahmani, AM, Rahmawaty, S, Rajesh, A, Ranasinghe, P, Rao, CR, Rao, SJ, Rashidi, M, Rashidi, M-M, Rawaf, DL, Rawaf, S, Rawassizadeh, R, Rezaei, N, Rezapour, A, Rezazadeh-Khadem, S, Rodriguez, JAB, Rwegerera, GM, Sabour, S, Saddik, B, Saeb, MR, Saeed, U, Sahebkar, A, Saif-Ur-Rahman, K, Salahi, S, Salimzadeh, H, Sampath, C, Samy, AM, Sanabria, J, Sanmarchi, F, Santric-Milicevic, MM, Sarveazad, A, Sathian, B, Sawhney, M, Seidu, A-A, Sepanlou, SG, Seylani, A, Shahabi, S, Shaikh, MA, Shaker, E, Shakhmardanov, MZ, Shannawaz, M, Shenoy, SM, Shetty, JK, Shetty, PH, Shibuya, K, Shin, JI, Shobeiri, P, Sibhat, MM, Singh, AD, Singh, JA, Singh, S, Skryabin, VY, Skryabina, AA, Sohrabpour, AA, Song, S, Tabaeian, SP, Tadesse, EG, Taheri, M, Tampa, M, Tan, K-K, Tavakoli, A, Tbakhi, A, Tefera, BN, Tehrani-Banihashemi, A, Tesfaw, HM, Thapar, R, Thavamani, A, Tohidast, SA, Tollosa, DN, Tosti, ME, Tovani-Palone, MR, Traini, E, Mai, TNT, Trihandini, I, Tusa, BS, Ullah, I, Vacante, M, Tahbaz, SV, Valdez, PR, Varthya, SB, Vo, B, Waheed, Y, Weldesenbet, AB, Woldemariam, M, Xu, S, Jabbari, SHY, Yaseri, M, Yeshaw, Y, Yigit, V, Yirdaw, BW, Yonemoto, N, Yu, C, Yunusa, I, Zahir, M, Zaki, L, Zamani, M, Zamanian, M, Zastrozhin, MS, Vos, T, Ward, JW, Dirac, MA, Sheena, BS, Hiebert, L, Han, H, Ippolito, H, Abbasi-Kangevari, M, Abbasi-Kangevari, Z, Abbastabar, H, Abdoli, A, Ali, HA, Adane, MM, Adegboye, OA, Adnani, QES, Advani, SM, Afzal, MS, Afzal, S, Meybodi, MA, Ahadinezhad, B, Ahinkorah, BO, Ahmad, S, Ahmad, T, Ahmadi, S, Ahmed, H, Ahmed, MB, Rashid, TA, Akalu, GT, Aklilu, A, Akram, T, Al Hamad, H, Alahdab, F, Alem, AZ, Alem, DT, Alhalaiqa, FAN, Alhassan, RK, Ali, L, Ali, MA, Alimohamadi, Y, Alipour, V, Alkhayyat, M, Almustanyir, S, Al-Raddadi, RM, Altawalah, H, Amini, S, Amu, H, Ancuceanu, R, Andrei, CL, Andrei, T, Anoushiravani, A, Ansar, A, Anyasodor, AE, Arabloo, J, Arab-Zozani, M, Argaw, AM, Argaw, ZG, Arshad, M, Artamonov, AA, Ashraf, T, Atlaw, D, Ausloos, F, Ausloos, M, Azadnajafabad, S, Azangou-Khyavy, M, Jafari, AA, Azarian, G, Bagheri, S, Bahadory, S, Baig, AA, Banach, M, Barati, N, Barrow, A, Batiha, A-MM, Ramirez, DFB, Belgaumi, UI, Berhie, AY, Bhagat, DS, Bhardwaj, N, Bhardwaj, P, Bhattacharyya, K, Bhojaraja, VS, Bijani, A, Biondi, A, Bodicha, BBA, Bojia, HA, Boloor, A, Bosetti, C, Braithwaite, D, Briko, NI, Butt, ZA, Camera, LA, Chakinala, RC, Chakraborty, PA, Charan, J, Chen, S, Choi, J-YJ, Choudhari, SG, Chowdhury, FR, Chu, D-T, Chung, S-C, Cortesi, PA, Cowie, BC, Culbreth, GT, Dadras, O, Dai, X, Dandona, L, Dandona, R, De la Hoz, FP, Debela, SA, Dedefo, MG, Demeke, FM, Demie, TGG, Demissie, GD, Molla, MD, Desta, AA, Dhamnetiya, D, Dhimal, ML, Dhimal, M, Didehdar, M, Doan, LP, Dorostkar, F, Drake, TM, Eghbalian, F, Ekholuenetale, M, El Sayed, I, Zaki, MES, Elhadi, M, Elmonem, MA, Elsharkawy, A, Enany, S, Enyew, DB, Erkhembayar, R, Eskandarieh, S, Esmaeilzadeh, F, Ezzikouri, S, Farrokhpour, H, Fetensa, G, Fischer, F, Foroutan, M, Gad, MM, Gaidhane, AM, Gaidhane, S, Galles, NC, Gallus, S, Gebremeskel, TG, Gebreyohannes, EA, Ghadiri, K, Ghaffari, K, Ghafourifard, M, Ghamari, S-H, Ghashghaee, A, Gholami, A, Gholizadeh, A, Gilani, A, Goel, A, Golechha, M, Goleij, P, Golinelli, D, Gorini, G, Goshu, YA, Griswold, MG, Gubari, MIM, Gupta, B, Gupta, S, Gupta, VB, Gupta, VK, Haddadi, R, Halwani, R, Hamid, SS, Hamidi, S, Hanif, A, Haque, S, Harapan, H, Hargono, A, Hariri, S, Hasaballah, A, Hasan, SMM, Hassanipour, S, Hassankhani, H, Hay, S, Hayat, K, Heidari, G, Herteliu, C, Heyi, DZ, Hezam, K, Holla, R, Hosseini, M-S, Hosseini, M, Hosseinzadeh, M, Hostiuc, M, Househ, M, Huang, J, Hussein, NR, Iavicoli, I, Ibitoye, SE, Ilesanmi, OS, Ilic, IM, Ilic, MD, Irham, LM, Islam, JY, Ismail, NE, Jacobsen, KH, Jadidi-Niaragh, F, Mamaghani, AJ, Jayaram, S, Jayawardena, R, Jebai, R, Jha, RP, Joseph, N, Joukar, F, Kaambwa, B, Kabir, A, Kabir, Z, Kalhor, R, Kandel, H, Kanko, TKT, Kantar, RS, Karaye, IM, Kassa, BG, Bohan, PMK, Keykhaei, M, Khader, YS, Khajuria, H, Khan, G, Khan, IA, Khan, J, Ab Khan, M, Khanali, J, Khater, AM, Khatib, MN, Khodadost, M, Khoja, AT, Khosravizadeh, O, Khubchandani, J, Kim, GR, Kim, H, Kim, MS, Kim, YJ, Kocarnik, JM, Kolahi, A-A, Koteeswaran, R, Kumar, GA, La Vecchia, C, Lal, DK, Landires, I, Lasrado, S, Lazarus, J, Ledda, C, Lee, DW, Lee, S-W, Lee, YY, Levi, M, Li, J, Lim, SS, Lobo, SW, Lopukhov, PD, Loureiro, JA, MacLachlan, JH, Razek, HMAE, Razek, MMAE, Majeed, A, Makki, A, Malekpour, M-R, Malekzadeh, R, Malik, AA, Mansour-Ghanaei, F, Mansournia, MA, Martins-Melo, FR, Matthews, PC, Mendoza, W, Menezes, RG, Meretoja, TJ, Mersha, AG, Mestrovic, T, Miller, TR, Minh, LHN, Mirica, A, Mirmoeeni, S, Mirrakhimov, EM, Misra, S, Mithra, P, Moazen, B, Mohamadkhani, A, Mohammadi, M, Mohammed, S, Moka, N, Mokdad, AH, Moludi, J, Momtazmanesh, S, Monasta, L, Moradi, G, Moradzadeh, M, Moradzadeh, R, Moraga, P, Mostafavi, E, Mubarik, S, Muniyandi, M, Murray, CJL, Naghavi, M, Naimzada, MD, Swamy, SN, Natto, ZS, Nayak, BP, Nazari, J, Negoi, I, Negru, SM, Nejadghaderi, SA, Kandel, SN, Nguyen, HLT, Ngwa, CH, Niazi, RK, Nnaji, CA, Noubiap, JJ, Nowroozi, A, Nunez-Samudio, V, Oancea, B, Ochir, C, Odukoya, OO, Oh, I-H, Olagunju, AT, Olakunde, BO, Bali, AO, Omer, E, Otstavnov, SS, Oumer, B, Padubidri, JR, Pana, A, Pandey, A, Park, E-C, Kan, FP, Patel, UK, Paudel, U, Petcu, I-R, Piracha, ZZ, Pollok, RCG, Postma, MJ, Pourshams, A, Poustchi, H, Rabiee, M, Rabiee, N, Rafiei, A, Rafiei, S, Raghuram, PM, Rahman, M, Rahmani, AM, Rahmawaty, S, Rajesh, A, Ranasinghe, P, Rao, CR, Rao, SJ, Rashidi, M, Rashidi, M-M, Rawaf, DL, Rawaf, S, Rawassizadeh, R, Rezaei, N, Rezapour, A, Rezazadeh-Khadem, S, Rodriguez, JAB, Rwegerera, GM, Sabour, S, Saddik, B, Saeb, MR, Saeed, U, Sahebkar, A, Saif-Ur-Rahman, K, Salahi, S, Salimzadeh, H, Sampath, C, Samy, AM, Sanabria, J, Sanmarchi, F, Santric-Milicevic, MM, Sarveazad, A, Sathian, B, Sawhney, M, Seidu, A-A, Sepanlou, SG, Seylani, A, Shahabi, S, Shaikh, MA, Shaker, E, Shakhmardanov, MZ, Shannawaz, M, Shenoy, SM, Shetty, JK, Shetty, PH, Shibuya, K, Shin, JI, Shobeiri, P, Sibhat, MM, Singh, AD, Singh, JA, Singh, S, Skryabin, VY, Skryabina, AA, Sohrabpour, AA, Song, S, Tabaeian, SP, Tadesse, EG, Taheri, M, Tampa, M, Tan, K-K, Tavakoli, A, Tbakhi, A, Tefera, BN, Tehrani-Banihashemi, A, Tesfaw, HM, Thapar, R, Thavamani, A, Tohidast, SA, Tollosa, DN, Tosti, ME, Tovani-Palone, MR, Traini, E, Mai, TNT, Trihandini, I, Tusa, BS, Ullah, I, Vacante, M, Tahbaz, SV, Valdez, PR, Varthya, SB, Vo, B, Waheed, Y, Weldesenbet, AB, Woldemariam, M, Xu, S, Jabbari, SHY, Yaseri, M, Yeshaw, Y, Yigit, V, Yirdaw, BW, Yonemoto, N, Yu, C, Yunusa, I, Zahir, M, Zaki, L, Zamani, M, Zamanian, M, Zastrozhin, MS, Vos, T, Ward, JW, and Dirac, MA

Abstract

BACKGROUND: Combating viral hepatitis is part of the UN Sustainable Development Goals (SDGs), and WHO has put forth hepatitis B elimination targets in its Global Health Sector Strategy on Viral Hepatitis (WHO-GHSS) and Interim Guidance for Country Validation of Viral Hepatitis Elimination (WHO Interim Guidance). We estimated the global, regional, and national prevalence of hepatitis B virus (HBV), as well as mortality and disability-adjusted life-years (DALYs) due to HBV, as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. This included estimates for 194 WHO member states, for which we compared our estimates to WHO elimination targets. METHODS: The primary data sources were population-based serosurveys, claims and hospital discharges, cancer registries, vital registration systems, and published case series. We estimated chronic HBV infection and the burden of HBV-related diseases, defined as an aggregate of cirrhosis due to hepatitis B, liver cancer due to hepatitis B, and acute hepatitis B. We used DisMod-MR 2.1, a Bayesian mixed-effects meta-regression tool, to estimate the prevalence of chronic HBV infection, cirrhosis, and aetiological proportions of cirrhosis. We used mortality-to-incidence ratios modelled with spatiotemporal Gaussian process regression to estimate the incidence of liver cancer. We used the Cause of Death Ensemble modelling (CODEm) model, a tool that selects models and covariates on the basis of out-of-sample performance, to estimate mortality due to cirrhosis, liver cancer, and acute hepatitis B. FINDINGS: In 2019, the estimated global, all-age prevalence of chronic HBV infection was 4·1% (95% uncertainty interval [UI] 3·7 to 4·5), corresponding to 316 million (284 to 351) infected people. There was a 31·3% (29·0 to 33·9) decline in all-age prevalence between 1990 and 2019, with a more marked decline of 76·8% (76·2 to 77·5) in prevalence in children younger than 5 years. HBV-related diseases resulted in 555 0

Published
2022

45. A framework for considering the utility of models when facing tough decisions in public health: a guideline for policy-makers

Author

Thompson, J, McClure, R, Scott, N, Hellard, M, Abeysuriya, R, Vidanaarachchi, R, Thwaites, J, Lazarus, J, Lavis, J, Michie, S, Bullen, C, Prokopenko, M, Chang, SL, Cliff, OM, Zachreson, C, Blakely, A, Wilson, T, Ouakrim, DA, Sundararajan, V, Thompson, J, McClure, R, Scott, N, Hellard, M, Abeysuriya, R, Vidanaarachchi, R, Thwaites, J, Lazarus, J, Lavis, J, Michie, S, Bullen, C, Prokopenko, M, Chang, SL, Cliff, OM, Zachreson, C, Blakely, A, Wilson, T, Ouakrim, DA, and Sundararajan, V

Abstract

The COVID-19 pandemic has brought the combined disciplines of public health, infectious disease and policy modelling squarely into the spotlight. Never before have decisions regarding public health measures and their impacts been such a topic of international deliberation, from the level of individuals and communities through to global leaders. Nor have models-developed at rapid pace and often in the absence of complete information-ever been so central to the decision-making process. However, after nearly 3 years of experience with modelling, policy-makers need to be more confident about which models will be most helpful to support them when taking public health decisions, and modellers need to better understand the factors that will lead to successful model adoption and utilization. We present a three-stage framework for achieving these ends.

Published
2022

46. A multinational Delphi consensus to end the COVID-19 public health threat

Author

Lazarus, J, Romero, D, Kopka, CJ, Karim, SA, Abu-Raddad, LJ, Almeida, G, Baptista-Leite, R, Barocas, JA, Barreto, ML, Bar-Yam, Y, Bassat, Q, Batista, C, Bazilian, M, Chiou, S-T, del Rio, C, Dore, GJ, Gao, GF, Gostin, LO, Hellard, M, Jimenez, JL, Kang, G, Lee, N, Maticic, M, McKee, M, Nsanzimana, S, Oliu-Barton, M, Pradelski, B, Pyzik, O, Rabin, K, Raina, S, Rashid, SF, Rathe, M, Saenz, R, Singh, S, Trock-Hempler, M, Villapol, S, Yap, P, Binagwaho, A, Kamarulzaman, A, El-Mohandes, A, Lazarus, J, Romero, D, Kopka, CJ, Karim, SA, Abu-Raddad, LJ, Almeida, G, Baptista-Leite, R, Barocas, JA, Barreto, ML, Bar-Yam, Y, Bassat, Q, Batista, C, Bazilian, M, Chiou, S-T, del Rio, C, Dore, GJ, Gao, GF, Gostin, LO, Hellard, M, Jimenez, JL, Kang, G, Lee, N, Maticic, M, McKee, M, Nsanzimana, S, Oliu-Barton, M, Pradelski, B, Pyzik, O, Rabin, K, Raina, S, Rashid, SF, Rathe, M, Saenz, R, Singh, S, Trock-Hempler, M, Villapol, S, Yap, P, Binagwaho, A, Kamarulzaman, A, and El-Mohandes, A

Abstract

Despite notable scientific and medical advances, broader political, socioeconomic and behavioural factors continue to undercut the response to the COVID-19 pandemic1,2. Here we convened, as part of this Delphi study, a diverse, multidisciplinary panel of 386 academic, health, non-governmental organization, government and other experts in COVID-19 response from 112 countries and territories to recommend specific actions to end this persistent global threat to public health. The panel developed a set of 41 consensus statements and 57 recommendations to governments, health systems, industry and other key stakeholders across six domains: communication; health systems; vaccination; prevention; treatment and care; and inequities. In the wake of nearly three years of fragmented global and national responses, it is instructive to note that three of the highest-ranked recommendations call for the adoption of whole-of-society and whole-of-government approaches1, while maintaining proven prevention measures using a vaccines-plus approach2 that employs a range of public health and financial support measures to complement vaccination. Other recommendations with at least 99% combined agreement advise governments and other stakeholders to improve communication, rebuild public trust and engage communities3 in the management of pandemic responses. The findings of the study, which have been further endorsed by 184 organizations globally, include points of unanimous agreement, as well as six recommendations with >5% disagreement, that provide health and social policy actions to address inadequacies in the pandemic response and help to bring this public health threat to an end.

Published
2022

47. IRONMAN: A Novel International Registry of Men With Advanced Prostate Cancer.

Author

Mucci, LA, Vinson, J, Gold, T, Gerke, T, Filipenko, J, Green, RM, Anderson, SG, Badal, S, Bjartell, A, Chi, KN, Davis, ID, Enting, D, Fay, AP, Lazarus, J, Mateo, J, McDermott, R, Odedina, FT, Olmos, D, Omlin, A, Popoola, AA, Ragin, C, Roberts, R, Russnes, KM, Waihenya, C, Stopsack, KH, Hyslop, T, Villanti, P, Kantoff, PW, George, DJ, IRONMAN Global Team, Mucci, LA, Vinson, J, Gold, T, Gerke, T, Filipenko, J, Green, RM, Anderson, SG, Badal, S, Bjartell, A, Chi, KN, Davis, ID, Enting, D, Fay, AP, Lazarus, J, Mateo, J, McDermott, R, Odedina, FT, Olmos, D, Omlin, A, Popoola, AA, Ragin, C, Roberts, R, Russnes, KM, Waihenya, C, Stopsack, KH, Hyslop, T, Villanti, P, Kantoff, PW, George, DJ, and IRONMAN Global Team

Abstract

PURPOSE: To describe a newly established international registry recruiting diverse patients with advanced prostate cancer across academic and community practices to address unmet needs in this population. PATIENTS AND METHODS: Initiated in 2017, IRONMAN (International Registry for Men with Advanced Prostate Cancer) is a prospective cohort of patients with advanced prostate cancer. The study will enroll 5,000 patients with metastatic hormone-sensitive prostate cancer (mHSPC) or castration-resistant prostate cancer (CRPC), recruited from Australia, the Bahamas, Barbados, Brazil, Canada, Ireland, Jamaica, Kenya, Nigeria, Norway, South Africa, Spain, Sweden, Switzerland, the United Kingdom, and the United States. The study is collecting datatypes to study variation in care and treatment of advanced prostate cancer across countries and across academic, community-based, and government practices with a focus on clinical outcomes, patient-reported outcomes, epidemiologic data, biologic subtypes, and clinician questionnaires. RESULTS: Through July 2022, 2,682 eligible patients were enrolled in 11 of 12 active countries. Sixty-six percent of patients have mHSPC, and 34% have CRPC. On the basis of self-report, 11% of patients are Black and 9% are Hispanic. Five Veterans Affairs Medical Centers are enrolling patients. Globally, 23% of patients report being veterans of military service. CONCLUSION: To our knowledge, this is the first international cohort of people newly diagnosed with advanced prostate cancer designed to describe variations in patient management, experiences, and outcomes. IRONMAN aims to identify optimal treatment sequences to improve survival, understand patient-reported outcomes, and explore novel biomarkers to understand treatment resistance mechanisms. Insights from IRONMAN will inform and guide future clinical management of people with mHSPC and CRPC. This cohort study will provide real-world evidence to facilitate a better understanding of the survivorshi

Published
2022

48. A multinational Delphi consensus to end the COVID-19 public health threat

Author

Lazarus, J. V., Romero, D., Kopka, C. J., Karim, S. A., Abu-Raddad, L. J., Almeida, G., Baptista-Leite, R., Barocas, J. A., Barreto, M. L., Bar-Yam, Y., Bassat, Q., Batista, C., Bazilian, M., Chiou, S. -T., del Rio, C., Dore, G. J., Gao, G. F., Gostin, L. O., Hellard, M., Jimenez, J. L., Kang, G., Lee, N., Maticic, M., Mckee, M., Nsanzimana, S., Oliu-Barton, M., Pradelski, B., Pyzik, O., Rabin, K., Raina, S., Rashid, S. F., Rathe, M., Saenz, R., Singh, S., Trock-Hempler, M., Villapol, S., Yap, P., Binagwaho, A., Kamarulzaman, A., El-Mohandes, A., Barreto, M., Abdulla, S., Addleman, S., Aghayeva, G., Agius, R., Ahmed, M., Ramy, M. A., Aide, P., Aleman, S., Alfred, J. -P., Ali, S., Aliaga, J., Aloudat, T., Alqahtani, S. A., Al-Salman, J., Amuasi, J. H., Agrawal, A., Anwar, W., Araujo-Jorge, T., Artaza, O., Asadi, L., Awuku, Y., Baker, M., Barberia, L., Bascolo, E., Belcher, P., Bell, L., Benzaken, A., Bergholtz, E., Bhadelia, N., Bhan, A., Bilodeau, S., Bitran, R., Bluyssen, P., Bosman, A., Bozza, F. A., Brinkmann, M. M., Brown, A., Mellado, B., Bukusi, E., Bullen, C., Buonanno, G., Burgess, R., Butler, M., Byakika-Kibwika, P., Cabieses, B., Carlsson, G., Cascini, Fidelia, Chabala, C., Chakroun, M., Cheng, K. K., Chetty, A., Chumachenko, D., Consalves, G., Conway Morris, A., Cordie, A., Corrah, T., Crabtree-Ramirez, B., Dashdorj, N., Davidovitch, N., de Souza, L. E., Dhariwal, A. C., Druica, E., Ergonul, O., Erondu, N. A., Essar, M. Y., Ewing, A., Fanjul, G., Feierstein, D., Feigl-Ding, E., Figueroa, R., Figueroa, J. P., Fisher, D., Flores, W., Forero-Pena, D. A., Frumkin, H., Gamkrelidze, A., Gandhi, M., Garcia, P., Garcia-Basteiro, A. L., Garcia-Sastre, A., Garg, S., Gbeasor-Komlanvi, F. A., Gershenson, C., Gilada, I., Giovanella, L., Gonzalez, M., Green, M. S., Greenhalgh, T., Griffin, P., Griffin, S., Grinsztejn, B., Anand, T., Guerra, G., Guinto, R., Gujski, M., Guner, R., Hamdy, A., Hancean, M. -G., Haniffa, A., Hartigan-Go, K. Y., Hassan, H. K., Hay, S. I., Heino, M. T. J., Hel, Z., Hotez, P., Hu, J., Hukic, M., Ijsselmuiden, C., Iroko, D., Iskarous, M., Izugbara, C., Jacobs, C., Jadad, A. R., Jehan, F., Jordan, A., Jroundi, I., Kain, K., Kamberi, F., Karamov, E., Karan, A., Katz, R., Katzourakis, A., Kazembe, A., Khamis, F., Khamzayev, K., Khanyola, J., Khunti, K., Kiguli-Malwadde, E., Kim, W. J., Kirenga, B. J., Klimovsky, D., Kmush, B. L., Knaul, F., Kogevinas, M., Kristensen, F., Kumar, D., Kumar, R., Kvalsvig, A., Lacerda, M. V., Lal, A., Lawton, T., Lemery, J., Leonardi, A. J., Li, Y., Lottvall, J., Lounis, M., Maceira, D., Macintyre, C. R., Madani, A., Magiorkinis, G., Malekzadeh, R., Choisy, M., Marcelin, J. R., Marks, G. B., Marr, L., Marrazzo, J., Martina, A., Martin-Moreno, J. M., Mateos, C., Mayxay, M., Mazarati, J. B., Mboup, S., Mcdonald, J., Mcmillan, F., Mechili, E., Medici, A., Davis, S. L. M., Meier, P., Memish, Z. A., Menon, J., Menon, P., Mesiano-Crookston, J., Michie, S., Mikolasevic, I., Milicevic, O., Mishra, A. K., Mohamed, R., Mokdad, A. H., Monroy-Valle, M., Morawska, L., Moschos, S. A., Motawea, K., Mousavi, S. H., Mumtaz, G., Munene, P. K., Munoz Almagro, C., Muriuki, J., Muyingo, S., Naniche, D., Naylor, C. D., Ndembi, N., Nemec, J., Nesteruk, I., Ngaruiya, C., Nguyen, H., Nikolova, D., Nitzan, D., Norheim, O., Noushad, M., Ntoumi, F., Nyborg, G. A., Ochodo, E., Odabasi, Z., Okwen, M. P., Olivia, K., Ong, D. S. Y., Opara, I., Orozco, M., Oshitani, H., Pagel, C., Pai, M., Palsdottir, B., Papatheodoridis, G., Paraskevis, D., Leigh, J. P., Pecoul, B., Peichl, A., Perez-Then, E., Duc, P. P., Philippe, C., Pineda Rojas, A., Pladsen, C., Pozniak, A., Quiroga, R., Qureshi, H., Rampal, S., Ranney, M., Rathe, L., Ratzan, S., Raventos, H., Rees, H., Reis, R., Ricciardi, Walter, Rizk, N., Robalo, M., Robertson, E., Robinson, L., Rokx, C., Ros, T., Rottingen, J. -A., Rubin, M., Ruxrungtam, K., Sadirova, S., Saha, S., Salgado, N., Sanchez, L., Sangaramoorthy, T., Santamaria-Ulloa, C., Santos, R., Sawaf, B., Schneider, M. F., Schooley, R. T., Sener, A., Sepulveda, J., Shah, J., Shibani, M., Shoib, S., Sikazwe, I., Simaitis, A., Gill, A. S., Skhvitaridze, N., Sokolovic, M., Solomon, R., Solorzano, X., Springer, S. A., Srol, J., Staines, A., Stelfox, H. T., Strathdee, S., Sulaiman, L. H., Sutton, B., Svanaes, D., Swed, S., Sypsa, V., Sorensen, K., Tajudeen, R., Tan, A., Tang, J., Tanner, M., Sethi, T., Temmerman, M., Than, K. K., Tinto, H., Tometissi, S. P., Torres, I., Tshering, K. P., Tsiodras, S., Tsofa, B., Vahlne, A., Vargas, J. R., Bernal, I. D. V., Ventura, D., Vilasanjuan, R., Vipond, J., Wamala-Andersson, S., Wargocki, P., West, R., Weyand, A., White, T. M., Wolff, G., Yao, M., Yates, C. A., Yeboah, G., Yee-Sin, L., Yi, S., Teo, Y. -Y., Yong, P., Zamora-Mesia, V., Ovrehus, A., Cascini F. (ORCID:0000-0001-6499-0734), Ricciardi W. (ORCID:0000-0002-5655-688X), Lazarus, J. V., Romero, D., Kopka, C. J., Karim, S. A., Abu-Raddad, L. J., Almeida, G., Baptista-Leite, R., Barocas, J. A., Barreto, M. L., Bar-Yam, Y., Bassat, Q., Batista, C., Bazilian, M., Chiou, S. -T., del Rio, C., Dore, G. J., Gao, G. F., Gostin, L. O., Hellard, M., Jimenez, J. L., Kang, G., Lee, N., Maticic, M., Mckee, M., Nsanzimana, S., Oliu-Barton, M., Pradelski, B., Pyzik, O., Rabin, K., Raina, S., Rashid, S. F., Rathe, M., Saenz, R., Singh, S., Trock-Hempler, M., Villapol, S., Yap, P., Binagwaho, A., Kamarulzaman, A., El-Mohandes, A., Barreto, M., Abdulla, S., Addleman, S., Aghayeva, G., Agius, R., Ahmed, M., Ramy, M. A., Aide, P., Aleman, S., Alfred, J. -P., Ali, S., Aliaga, J., Aloudat, T., Alqahtani, S. A., Al-Salman, J., Amuasi, J. H., Agrawal, A., Anwar, W., Araujo-Jorge, T., Artaza, O., Asadi, L., Awuku, Y., Baker, M., Barberia, L., Bascolo, E., Belcher, P., Bell, L., Benzaken, A., Bergholtz, E., Bhadelia, N., Bhan, A., Bilodeau, S., Bitran, R., Bluyssen, P., Bosman, A., Bozza, F. A., Brinkmann, M. M., Brown, A., Mellado, B., Bukusi, E., Bullen, C., Buonanno, G., Burgess, R., Butler, M., Byakika-Kibwika, P., Cabieses, B., Carlsson, G., Cascini, Fidelia, Chabala, C., Chakroun, M., Cheng, K. K., Chetty, A., Chumachenko, D., Consalves, G., Conway Morris, A., Cordie, A., Corrah, T., Crabtree-Ramirez, B., Dashdorj, N., Davidovitch, N., de Souza, L. E., Dhariwal, A. C., Druica, E., Ergonul, O., Erondu, N. A., Essar, M. Y., Ewing, A., Fanjul, G., Feierstein, D., Feigl-Ding, E., Figueroa, R., Figueroa, J. P., Fisher, D., Flores, W., Forero-Pena, D. A., Frumkin, H., Gamkrelidze, A., Gandhi, M., Garcia, P., Garcia-Basteiro, A. L., Garcia-Sastre, A., Garg, S., Gbeasor-Komlanvi, F. A., Gershenson, C., Gilada, I., Giovanella, L., Gonzalez, M., Green, M. S., Greenhalgh, T., Griffin, P., Griffin, S., Grinsztejn, B., Anand, T., Guerra, G., Guinto, R., Gujski, M., Guner, R., Hamdy, A., Hancean, M. -G., Haniffa, A., Hartigan-Go, K. Y., Hassan, H. K., Hay, S. I., Heino, M. T. J., Hel, Z., Hotez, P., Hu, J., Hukic, M., Ijsselmuiden, C., Iroko, D., Iskarous, M., Izugbara, C., Jacobs, C., Jadad, A. R., Jehan, F., Jordan, A., Jroundi, I., Kain, K., Kamberi, F., Karamov, E., Karan, A., Katz, R., Katzourakis, A., Kazembe, A., Khamis, F., Khamzayev, K., Khanyola, J., Khunti, K., Kiguli-Malwadde, E., Kim, W. J., Kirenga, B. J., Klimovsky, D., Kmush, B. L., Knaul, F., Kogevinas, M., Kristensen, F., Kumar, D., Kumar, R., Kvalsvig, A., Lacerda, M. V., Lal, A., Lawton, T., Lemery, J., Leonardi, A. J., Li, Y., Lottvall, J., Lounis, M., Maceira, D., Macintyre, C. R., Madani, A., Magiorkinis, G., Malekzadeh, R., Choisy, M., Marcelin, J. R., Marks, G. B., Marr, L., Marrazzo, J., Martina, A., Martin-Moreno, J. M., Mateos, C., Mayxay, M., Mazarati, J. B., Mboup, S., Mcdonald, J., Mcmillan, F., Mechili, E., Medici, A., Davis, S. L. M., Meier, P., Memish, Z. A., Menon, J., Menon, P., Mesiano-Crookston, J., Michie, S., Mikolasevic, I., Milicevic, O., Mishra, A. K., Mohamed, R., Mokdad, A. H., Monroy-Valle, M., Morawska, L., Moschos, S. A., Motawea, K., Mousavi, S. H., Mumtaz, G., Munene, P. K., Munoz Almagro, C., Muriuki, J., Muyingo, S., Naniche, D., Naylor, C. D., Ndembi, N., Nemec, J., Nesteruk, I., Ngaruiya, C., Nguyen, H., Nikolova, D., Nitzan, D., Norheim, O., Noushad, M., Ntoumi, F., Nyborg, G. A., Ochodo, E., Odabasi, Z., Okwen, M. P., Olivia, K., Ong, D. S. Y., Opara, I., Orozco, M., Oshitani, H., Pagel, C., Pai, M., Palsdottir, B., Papatheodoridis, G., Paraskevis, D., Leigh, J. P., Pecoul, B., Peichl, A., Perez-Then, E., Duc, P. P., Philippe, C., Pineda Rojas, A., Pladsen, C., Pozniak, A., Quiroga, R., Qureshi, H., Rampal, S., Ranney, M., Rathe, L., Ratzan, S., Raventos, H., Rees, H., Reis, R., Ricciardi, Walter, Rizk, N., Robalo, M., Robertson, E., Robinson, L., Rokx, C., Ros, T., Rottingen, J. -A., Rubin, M., Ruxrungtam, K., Sadirova, S., Saha, S., Salgado, N., Sanchez, L., Sangaramoorthy, T., Santamaria-Ulloa, C., Santos, R., Sawaf, B., Schneider, M. F., Schooley, R. T., Sener, A., Sepulveda, J., Shah, J., Shibani, M., Shoib, S., Sikazwe, I., Simaitis, A., Gill, A. S., Skhvitaridze, N., Sokolovic, M., Solomon, R., Solorzano, X., Springer, S. A., Srol, J., Staines, A., Stelfox, H. T., Strathdee, S., Sulaiman, L. H., Sutton, B., Svanaes, D., Swed, S., Sypsa, V., Sorensen, K., Tajudeen, R., Tan, A., Tang, J., Tanner, M., Sethi, T., Temmerman, M., Than, K. K., Tinto, H., Tometissi, S. P., Torres, I., Tshering, K. P., Tsiodras, S., Tsofa, B., Vahlne, A., Vargas, J. R., Bernal, I. D. V., Ventura, D., Vilasanjuan, R., Vipond, J., Wamala-Andersson, S., Wargocki, P., West, R., Weyand, A., White, T. M., Wolff, G., Yao, M., Yates, C. A., Yeboah, G., Yee-Sin, L., Yi, S., Teo, Y. -Y., Yong, P., Zamora-Mesia, V., Ovrehus, A., Cascini F. (ORCID:0000-0001-6499-0734), and Ricciardi W. (ORCID:0000-0002-5655-688X)

Abstract

Despite notable scientific and medical advances, broader political, socioeconomic and behavioural factors continue to undercut the response to the COVID-19 pandemic1,2. Here we convened, as part of this Delphi study, a diverse, multidisciplinary panel of 386 academic, health, non-governmental organization, government and other experts in COVID-19 response from 112 countries and territories to recommend specific actions to end this persistent global threat to public health. The panel developed a set of 41 consensus statements and 57 recommendations to governments, health systems, industry and other key stakeholders across six domains: communication; health systems; vaccination; prevention; treatment and care; and inequities. In the wake of nearly three years of fragmented global and national responses, it is instructive to note that three of the highest-ranked recommendations call for the adoption of whole-of-society and whole-of-government approaches1, while maintaining proven prevention measures using a vaccines-plus approach2 that employs a range of public health and financial support measures to complement vaccination. Other recommendations with at least 99% combined agreement advise governments and other stakeholders to improve communication, rebuild public trust and engage communities3 in the management of pandemic responses. The findings of the study, which have been further endorsed by 184 organizations globally, include points of unanimous agreement, as well as six recommendations with >5% disagreement, that provide health and social policy actions to address inadequacies in the pandemic response and help to bring this public health threat to an end.

Published
2022

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