182 results on '"Layton, Harold E."'
Search Results
2. The Physiology of Urinary Concentration: An Update
- Author
-
Sands, Jeff M. and Layton, Harold E.
- Published
- 2009
- Full Text
- View/download PDF
3. Maximum Urine Concentrating Capability in a Mathematical Model of the Inner Medulla of the Rat Kidney
- Author
-
Marcano, Mariano, Layton, Anita T., and Layton, Harold E.
- Published
- 2010
- Full Text
- View/download PDF
4. Hyperfiltration and inner stripe hypertrophy may explain findings by Gamble and coworkers
- Author
-
Layton, Anita T., Pannabecker, Thomas L., Dantzler, William H., and Layton, Harold E.
- Subjects
Hypertrophy -- Research ,Hypertrophy -- Risk factors ,Hypertrophy -- Development and progression ,Biological transport -- Genetic aspects ,Biological transport -- Research ,Biological sciences - Abstract
Simulations conducted iri a mathematical model were used to exemplify the hypothesis that elevated solute concentrations and tubular flows at the boundary of the renal outer and inner medullas of rats may contribute to increased urine osmolalities and urine flow rates. Such elevated quantities at that boundary may arise from hyperfiltration and from inner stripe hypertrophy, which are correlated with increased concentrating activity (Bankir L, Kriz W. Kidney Int. 47: 7-24, 1995). The simulations used the region-based model for the rat inner medulla that was presented in the companion study (Layton AT, Pannabecker TL, Dantzler WH, Layton HE. Am J Physiol Renal Physiol 298: F000-F000, 2010). The simulations were suggested by experiments which were conducted in rat by Gamble et al. (Gamble JL, McKhann CF, Butler AM, Tuthill E. Am J Physiol 109: 139-154, 1934) in which the ratio of NaCl to urea in the diet was systematically varied in eight successive 5-day intervals. The simulations predict that changes in boundary conditions at the boundary of the outer and inner medulla, accompanied by plausible modifications in transport properties of the collecting duct system, can significantly increase urine osmolality and flow rate. This hyperfiltration-hypertrophy hypothesis may explain the finding by Gamble et al. that the maximum urine osmolality attained from supplemental feeding of urea and NaCl in the eight intervals depends on NaCl being the initial predominant solute and on urea being the final predominant solute, because urea in sufficient quantity appears to stimulate concentrating activity. More generally, the hypothesis suggests that high osmolalities and urine flow rates may depend, in large part, on adaptive modifications of cortical hemodynamics and on outer medullary structure and not entirely on an extraordinary concentrating capability that is intrinsic to the inner medulla. urine concentrating mechanism: countercurrent system; renal inner medulla; NaCl transport: urea transport; mathematical model doi: 10.1152/ajprenal.00250.2009.
- Published
- 2010
5. Functional implications of the three-dimensional architecture of the rat renal inner medulla
- Author
-
Layton, Anita T., Pannabecker, Thomas L., Dantzler, William H., and Layton, Harold E.
- Subjects
Biological transport -- Physiological aspects ,Biological transport -- Genetic aspects ,Biological transport -- Research ,Mathematical models -- Usage ,Biological sciences - Abstract
A new, region-based mathematical model of the urine concentrating mechanism of the rat renal inner medulla (IM) was used to investigate the significance of transport and structural properties revealed in recent studies that employed immunohistochemical methods combined with three-dimensional computerized reconstruction. The model simulates preferential interactions among tubules and vessels by representing two concentric regions. The inner region, which represents a collecting duct (CD) cluster, contains CDs, some ascending thin limbs (ATLs), and some ascending vasa recta; the outer region, which represents the intercluster region, contains descending thin limbs, descending vasa recta, remaining ATLs, and additional ascending vasa recta. In the upper portion of the IM, the model predicts that interstitial [Na.sup.+] and urea concentrations (and osmolality) in the CD clusters differ significantly from those in the intercluster regions: model calculations predict that those CD clusters have higher urea concentrations than the intercluster regions, a finding that is consistent with a concentrating mechanism that depends principally on the mixing of NaCI from ATLs and urea from CDs. In the lower IM, the model predicts that limited or nearly zero water permeability in descending thin limb segments will increase concentrating effectiveness by increasing the rate of solute-free water absorption. The model predicts that high urea permeabilities in the upper portions of ATLs and increased contact areas of longest loop bends with CDs both modestly increase concentrating capability. A surprising finding is that the concentrating capability of this region-based model falls short of the capability of a model IM that has radially homogeneous interstitial fluid at each level but is otherwise analogous to the region-based model. countercurrent system; NaC1 transport; urea transport; mathematical model doi: 10.1152/ajprenal.00249.2009.
- Published
- 2010
6. Multistable Dynamics Mediated by Tubuloglomerular Feedback in a Model of Coupled Nephrons
- Author
-
Layton, Anita T., Moore, Leon C., and Layton, Harold E.
- Published
- 2009
- Full Text
- View/download PDF
7. 10 - Urine Concentration and Dilution
- Author
-
Sands, Jeff M., Layton, Harold E., and Fenton, Robert Andrew
- Published
- 2020
- Full Text
- View/download PDF
8. Role of three-dimensional architecture in the urine concentrating mechanism of the rat renal inner medulla
- Author
-
Pannabecker, Thomas L., Dantzler, William H., Layton, Harold E., and Layton, Anita T.
- Subjects
Mathematical models -- Usage ,Biological transport -- Evaluation ,Kidneys -- Properties ,Biological sciences - Abstract
Recent studies of three-dimensional architecture of rat renal inner medulla (IM) and expression of membrane proteins associated with fluid and solute transport in nephrons and vasculature have revealed structural and transport properties that likely impact the IM urine concentrating mechanism. These studies have shown that 1) IM descending thin limbs (DTLs) have at least two or three functionally distinct subsegments; 2) most ascending thin limbs (ATLs) and about half the ascending vasa recta (AVR) are arranged among clusters of collecting ducts (CDs), which form the organizing motif through the first 3-3.5 mm of the IM, whereas other ATLs and AVR, along with aquaporin-1-positive DTLs and urea transporter B-positive descending vasa recta (DVR), are external to the CD clusters; 3) ATLs, AVR, CDs, and interstitial cells delimit interstitial microdomains within the CD clusters; and 4) many of the longest loops of Henle form bends that include subsegments that run transversely along CDs that lie in the terminal 500 [micro]m of the papilla tip. Based on a more comprehensive understanding of three-dimensional IM architecture, we distinguish two distinct countercurrent systems in the first 3-3.5 mm of the IM (an intra-CD cluster system and an inter-CD cluster system) and a third countercurrent system in the final 1.5-2 mm. Spatial arrangements of loop of Henle subsegments and multiple countercurrent systems throughout four distinct axial IM zones, as well as our initial mathematical model, are consistent with a solute-separation, solute-mixing mechanism for concentrating urine in the IM. kidney; countercurrent system; computer-assisted reconstruction; functional anatomy; NaCl transport; urea transport; mathematical model
- Published
- 2008
9. An Optimization Algorithm for a Distributed-Loop Model of an Avian Urine Concentrating Mechanism
- Author
-
Marcano, Mariano, Layton, Anita T., and Layton, Harold E.
- Published
- 2006
- Full Text
- View/download PDF
10. The Urine Concentrating Mechanism and Urea Transporters
- Author
-
Sands, Jeff M., primary and Layton, Harold E., additional
- Published
- 2013
- Full Text
- View/download PDF
11. Multistability in tubuloglomerular feedback and spectral complexity in spontaneously hypertensive rats
- Author
-
Layton, Anita T., Moore, Leon C., and Layton, Harold E.
- Subjects
Hypertension -- Research ,Hemodynamics -- Research ,Kidneys -- Research ,Biological sciences - Abstract
Single-nephron proximal tubule pressure in spontaneously hypertensive rats (SHR) can exhibit highly irregular oscillations similar to deterministic chaos. We used a mathematical model of tubuloglomerular feedback (TGF) to investigate potential sources of the irregular oscillations and the corresponding complex power spectra in SHR. A bifurcation analysis of the TGF model equations, for nonzero thick ascending limb (TAL) NaCl permeability, was performed by finding roots of the characteristic equation, and numerical simulations of model solutions were conducted to assist in the interpretation of the analysis. These techniques revealed four parameter regions, consistent with TGF gain and delays in SHR, where multiple stable model solutions are possible: 1) a region having one stable, time-independent steady-state solution; 2) a region having one stable oscillatory solution only, of frequency [f.sub.1]; 3) a region having one stable oscillatory solution only, of frequency [f.sub.2], which is approximately equal to 2 [f.sub.1]; and 4) a region having two possible stable oscillatory solutions, of frequencies [f.sub.1] and [f.sub.2]. In addition, we conducted simulations in which TAL volume was assumed to vary as a function of time and simulations in which two or three nephrons were assumed to have coupled TGF systems. Four potential sources of spectral complexity in SHR were identified: l) bifurcations that permit switching between different stable oscillatory modes, leading to multiple spectral peaks and their respective harmonic peaks; 2) sustained lability in delay parameters, leading to broadening of peaks and of their harmonics; 3) episodic, but abrupt, lability in delay parameters, leading to multiple peaks and their harmonics; and 4) coupling of small numbers of nephrons, leading to multiple peaks and their harmonics. We conclude that the TGF system in SHR may exhibit multistability and that the complex power spectra of the irregular TGF fluctuations in this strain may be explained by switching between multiple dynamic modes, temporal variation in TGF parameters, and nephron coupling. renal hemodynamics; hypertension; mathematical model; nonlinear dynamical system
- Published
- 2006
12. Feedback-mediated dynamics in two coupled nephrons
- Author
-
Pitman, E. Bruce, Zaritski, Roman M., Kesseler, Kevin J., Moore, Leon C., and Layton, Harold E.
- Published
- 2004
- Full Text
- View/download PDF
13. A region-based mathematical model of the urine concentrating mechanism in the rat outer medulla. II. Parameter sensitivity and tubular inhomogeneity
- Author
-
Layton, Anita T. and Layton, Harold E.
- Subjects
Mathematical models -- Usage ,Rats -- Health aspects ,Rattus -- Health aspects ,Biological sciences - Abstract
In a companion study (Layton AT and Layton HE. Am J Physiol Renal Physiol 289: F1346-F1366, 2005), a region-based mathematical model was formulated for the urine concentrating mechanism (UCM) in the outer medulla (OM) of the rat kidney. In the present study, we quantified the sensitivity of that model to several structural assumptions, including the degree of regionalization and the degree of inclusion of short descending limbs (SDLs) in the vascular bundles of the inner stripe (IS). Also, we quantified model sensitivity to several parameters that have not been well characterized in the experimental literature, including boundary conditions, short vasa recta distribution, and ascending vasa recta (AVR) solute permeabilities. These studies indicate that regionalization elevates the osmolality of the fluid delivered into the inner medulla via the collecting ducts; that model predictions are not significantly sensitive to boundary conditions; and that short vasa recta distribution and AVR permeabilities significantly impact concentrating capability. Moreover, we investigated, in the context of the UCM, the functional significance of several aspects of tubular segmentation and heterogeneity: SDL segments in the IS that are likely to be impermeable to water but highly permeable to urea; a prebend segment of SDLs that may be functionally like thick ascending limb (TAL); differing IS and outer stripe [Na.sup.+] active transport rates in TAL; and potential active urea secretion into the proximal straight tubules. Model calculations predict that these aspects of tubular of segmentation and heterogeneity generally enhance solute cycling or promote effective UCM function. kidney; short loops of Henle; vascular bundle; vasa recta; [Na.sup.+] transport; urea transport
- Published
- 2005
14. A region-based mathematical model of the urine concentrating mechanism in the rat outer medulla. I. formulation and base-case results
- Author
-
Layton, Anita T. and Layton, Harold E.
- Subjects
Rats -- Health aspects ,Rattus -- Health aspects ,Mathematical models -- Usage ,Biological sciences - Abstract
We have developed a highly detailed mathematical model for the urine concentrating mechanism (UCM) of the rat kidney outer medulla (OM). The model simulates preferential interactions among tubules and vessels by representing four concentric regions that are centered on a vascular bundle; tubules and vessels, or fractions thereof, are assigned to anatomically appropriate regions. Model parameters, which are based on the experimental literature, include transepithelial transport properties of short descending limbs inferred from immunohistochemical localization studies. The model equations, which are based on conservation of solutes and water and on standard expressions for transmural transport, were solved to steady state. Model simulations predict significantly differing interstitial NaCl and urea concentrations in adjoining regions. Active NaCl transport from thick ascending limbs (TALs), at rates inferred from the physiological literature, resulted in model osmolality profiles along the OM that are consistent with tissue slice experiments. TAL luminal NaCl concentrations at the corticomedullary boundary are consistent with tubuloglomernlar feedback function. The model exhibited solute exchange, cycling, and sequestration patterns (in tubules, vessels, and regions) that are generally consistent with predictions in the physiological literature, including significant urea addition from long ascending vasa recta to inner-stripe short descending limbs. In a companion study (Layton AT and Layton HE. Am J Physiol Renal Physiol 289: F1367-F1381, 2005), the impact of model assumptions, medullary anatomy, and tubular segmentation on the UCM was investigated by means of extensive parameter studies. kidney; countercurrent multiplication; countercurrent exchange; NaCl transport; urea transport
- Published
- 2005
15. A region-based model framework for the rat urine concentrating mechanism
- Author
-
Layton, Anita T. and Layton, Harold E.
- Published
- 2003
- Full Text
- View/download PDF
16. An inverse algorithm for a mathematical model of an avian urine concentrating mechanism
- Author
-
Marcano-Velázquez, M. and Layton, Harold E.
- Published
- 2003
- Full Text
- View/download PDF
17. The Physiology of Water Homeostasis
- Author
-
Sands, Jeff M., primary, Mount, David B., additional, and Layton, Harold E., additional
- Published
- 2012
- Full Text
- View/download PDF
18. Contributors
- Author
-
Advani, Andrew, primary, Allon, Michael, additional, Anderson, Amanda Hyre, additional, Appel, Gerald B., additional, Assady, Suheir, additional, Atala, Anthony, additional, Baigent, Colin, additional, Bakkaloglu, Sevcan A., additional, Barletta, Gina-Marie, additional, Becker, Gavin J., additional, Bellomo, Rinaldo, additional, Berns, Jeffrey S., additional, Bhalla, Vivek, additional, Biber, Jürg, additional, Bichet, Daniel G., additional, Bindels, René J.M., additional, Bleicher, Melissa B., additional, Blumenfeld, Jon D., additional, Bonnardeaux, Alain, additional, Bonventre, Joseph V., additional, Boswell, William D., additional, Bowden, Donald W., additional, Brenner, Barry M., additional, Breyer, Matthew D., additional, Breyer, Richard M., additional, Brown, Dennis, additional, Brugnara, Carlo, additional, Bunchman, Timothy E., additional, Bushinsky, David A., additional, Busque, Stéphan, additional, Carrero, Juan Jesús, additional, Cattran, Daniel, additional, Chan, James C., additional, Chandraker, Anil, additional, Chang, Ingrid J., additional, Choudhury, Devasmita, additional, Coe, Fredric L., additional, Collins, John F., additional, Cook, H. Terence, additional, Correa-Rotter, Ricardo, additional, Cowper, Shawn E., additional, Cravedi, Paolo, additional, Cueto-Manzano, Alfonso M., additional, D’Agati, Vivette D., additional, Davids, Mogomat Razeen, additional, Delacroix, Scott E., additional, Denker, Bradley M., additional, Depner, Thomas A., additional, DuBose, Thomas D., additional, Eckardt, Kai-Uwe, additional, Eldehni, Mohamed T., additional, Ellison, David H., additional, Emmett, Michael, additional, Falk, Ronald J., additional, Feldman, Harold I., additional, Fenton, Robert A., additional, Fenves, Andrew Z., additional, Finkel, Kevin W., additional, Fioretto, Paola, additional, Fogarty, Damian G., additional, Foringer, John R., additional, Fouque, Denis, additional, Freedman, Barry I., additional, Frøkiaer, Jørgen, additional, Funder, John W., additional, Game, David S., additional, Gilbert, Richard E., additional, Grantham, Jared J., additional, Halperin, Mitchell L., additional, Hand, Matthew, additional, Hanes, Donna S., additional, Harris, David C.H., additional, Harris, Raymond C., additional, Haynes, Richard, additional, Hoenderop, Joost G.J., additional, Hoorn, Ewout J., additional, Hostetter, Thomas H., additional, Hsu, Chi-yuan, additional, Hua-Lin, Shih, additional, Ibrahim, Hassan N., additional, Israni, Ajay K., additional, Jadvar, Jossein, additional, Jennette, J. Charles, additional, Jonasch, Eric, additional, Kamel, Kamel S., additional, Karumanchi, S. Ananth, additional, Kasiske, Bertram L., additional, Kellum, John A., additional, Kelly, Carolyn J., additional, Khanna, Ramesh, additional, Klassen, David K., additional, Ko, Christine J., additional, Kohli, Harbir Singh, additional, Kost, Curtis K., additional, Krane, L. Spencer, additional, Kreidberg, Jordan, additional, Kwon, Tae-Hwan, additional, Lahoti, Amit, additional, Landray, Martin J., additional, Laragh, John H., additional, Layton, Harold E., additional, Levi, Moshe, additional, Lindholm, Bengt, additional, Liu, Frank, additional, Luyckx, Valerie A., additional, Maddox, David A., additional, Maezawa, Yoshiro, additional, Matas, Arthur J., additional, Mauer, Michael, additional, Maya, Ivan D., additional, Maynard, Sharon E., additional, McDonough, Alicia A., additional, McIntyre, Christopher W., additional, Meyer, Timothy W., additional, Mitch, William E., additional, Moe, Orson W., additional, Moe, Sharon M., additional, Molitoris, Bruce A., additional, Moss, Alvin H., additional, Mount, David B., additional, Munger, Karen A., additional, Nachman, Patrick H., additional, Naicker, Saraladevi, additional, Nielsen, Søren, additional, Neilson, Eric G., additional, Nicolle, Lindsay E., additional, Ornt, Daniel B., additional, Palacín, Manuel, additional, Palevsky, Paul M., additional, Palmer, Suzanne L., additional, Parving, Hans-Henrik, additional, Patrakka, Jaakko, additional, Pearce, David, additional, Pecoits-Filho, Roberto, additional, Peralta, Carmen A., additional, Perico, Norberto, additional, Powe, Neil R., additional, Praditpornsilpa, Kearkiat, additional, Prætorius, Jeppe, additional, Quaggin, Susan E., additional, Quarles, L. Darryl, additional, Radhakrishnan, Jai, additional, Ramadan, Rawi, additional, Reggenenti, Piero, additional, Reich, Heather N., additional, Remuzzi, Andrea, additional, Remuzzi, Giuseppe, additional, Rich, Stephen S., additional, Riella, Miguel C., additional, Ritz, Eberhard, additional, Ronco, Claudio, additional, Rosenblum, Norman D., additional, Rossing, Peter, additional, Rubinger, Dvora, additional, Rude, Robert K., additional, Sabath, Ernesto, additional, Sabbisetti, Venkata, additional, Sakhuja, Vinay, additional, Salama, Alan D., additional, Sands, Jeff M., additional, Santos, Fernando, additional, Sayegh, Mohamed H., additional, Scandling, John D., additional, Schaefer, Franz, additional, Scheinman, Jon I., additional, Schwartz, John C., additional, Sharfuddin, Asif A., additional, Shaw, Susan, additional, Sitprija, Visith, additional, Skorecki, Karl L., additional, Slotki, Itzchak N., additional, Smith, James P., additional, Smogorzewski, Miroslaw J., additional, Sprague, Stuart M., additional, Stenvinkel, Peter, additional, Stokes, John B., additional, Taal, Maarten W., additional, Tamura, Manjula Kurella, additional, Tan, Jane C., additional, Textor, Stephen C., additional, Thadhani, Ravi, additional, Thomson, Scott C., additional, Torres, Vincente E., additional, Tryggvason, Karl, additional, Tuncel, Meryem, additional, Tungsanga, Kriang, additional, Verbalis, Joseph G., additional, Verlander, Jill W., additional, Wadee, Shoyab, additional, Weiner, I. David, additional, Weir, Matthew R., additional, Weisbord, Steven D., additional, Wheeler, David C., additional, Wilcox, Christopher S., additional, Wood, Christopher G., additional, Wright, Stephen H., additional, Yeun, Jane Y., additional, Yu, Alan S.L., additional, Zandi-Nejad, Kambiz, additional, and Zeidel, Mark L., additional
- Published
- 2012
- Full Text
- View/download PDF
19. Urine Concentration and Dilution
- Author
-
Sands, Jeff M., primary, Layton, Harold E., additional, and Fenton, Robert A., additional
- Published
- 2012
- Full Text
- View/download PDF
20. List of Contributors
- Author
-
Abrahamson, Dale R., primary, Al-Awqati, Qais, additional, Alpern, Robert J., additional, Altenberg, Guillermo A., additional, Bailey, Matthew A., additional, Baum, Michel, additional, Bichet, Daniel G., additional, Blantz, Roland C., additional, Breyer, Matthew D., additional, Breyer, Richard M., additional, Brinkkoetter, Paul T., additional, Bush, Kevin T., additional, Cantley, Lloyd, additional, Cao, Chunhua, additional, Capasso, Giovambattista, additional, Castrop, Hayo, additional, Chan, Laurence, additional, Cina, Davide, additional, Coffman, Thomas M., additional, Crowley, Steven D., additional, Dimke, Henrik, additional, Eisner, Gilbert M., additional, Eladari, Dominique, additional, Ellison, David H., additional, Endou, Hitoshi, additional, Felder, Robin A., additional, Féraille, Eric, additional, Frøkiær, Jørgen, additional, Gamba, Gerardo, additional, Gattineni, Jyothsna, additional, Giebisch, Gerhard, additional, Gmurczyk, Aleksandra, additional, Granger, Joey P., additional, Griffin, Sian V., additional, Guggino, William B., additional, Gurley, Susan B., additional, Hall, John E., additional, Hall, Michael E., additional, Hallows, Kenneth R., additional, Hanner, Fiona, additional, Harris, Raymond C., additional, Hasler, Udo, additional, Kevin Hix, J., additional, Huang, Chou-Long, additional, Johns, Edward J., additional, Jose, Pedro A., additional, Kaissling, Brigitte, additional, Kleyman, Thomas R., additional, Kopp, Ulla C., additional, Kriz, Wilhelm, additional, Kwon, Tae-Hwan, additional, Lang, Florian, additional, Layton, Harold E., additional, Le, Thu H., additional, Lifton, Richard P., additional, Loffing, Johannes, additional, Maezawa, Yoshiro, additional, Malnic, Gerhard, additional, Matlin, Karl S., additional, Charles Michel, C., additional, Miner, Jeffrey H., additional, Muto, Shigeaki, additional, Nielsen, Søren, additional, Nigam, Sanjay K., additional, Oh, Man S., additional, Oliver, Juan A., additional, Pallone, Thomas L., additional, Palmer, Biff F., additional, Palmer, Lawrence G., additional, Peti-Peterdi, János, additional, Pieczynski, Jay N., additional, Quaggin, Susan E., additional, Reuss, Luis, additional, Rivard, Christopher J., additional, Robertson, Gary L., additional, Rosa, Robert M., additional, Sackin, Henry, additional, Sahni, Vaibhav, additional, Sakurai, Hiroyuki, additional, Sands, Jeff M., additional, Satlin, Lisa M., additional, Schild, Laurent, additional, Schnermann, Jürgen B., additional, Scholl, Ute I., additional, Sekine, Takashi, additional, Seldin, Donald W., additional, Shankland, Stuart J., additional, Sheng, Shaohu, additional, Shirley, David G., additional, Silver, Stephen M., additional, Skott, Martin, additional, Staub, Olivier, additional, Sterns, Richard H., additional, Stockand, James D., additional, Tam, Frederick W.K., additional, Thomson, Scott C., additional, Trepiccione, Francesco, additional, Unwin, Robert J., additional, Vesely, David L., additional, Wang, Wei, additional, Wang, Wenhui, additional, Weinstein, Alan M., additional, Welling, Paul A., additional, Wildman, Scott S.P., additional, Woodward, Owen M., additional, Yoder, Bradley K., additional, Yu, Alan S.L., additional, and Zacchia, Miriam, additional
- Published
- 2012
- Full Text
- View/download PDF
21. Two modes for concentrating urine in rat inner medulla
- Author
-
Layton, Anita T., Pannabecker, Thomas L., Dantzler, William H., and Layton, Harold E.
- Subjects
Medulla oblongata -- Research ,Biological sciences - Abstract
Two modes for concentrating urine in rat inner medulla. Am J Physiol Renal Physiol 287:F816-F839, 2004. First published June 22, 2004: 10.1152/ajprenal.00398.2003.--We used a mathematical model of the urine concentrating mechanism of rat inner medulla (IM) to investigate the implications of experimental studies in which immunohistochemical methods were combined with three-dimensional computerized reconstruction of renal tubules. The mathematical model represents a distribution of loops of Henle with loop bends at all levels of the IM, and the vasculature is represented by means of the central core assumption. Based on immunohistochemical evidence, descending limb portions that reach into the papilla are assumed to be only moderately water permeable or to be water impermeable, and only prebend segments and ascending thin limbs are assumed to be NaCl permeable. Model studies indicate that this configuration favors the targeted delivery of NaCl to loop bends, where a favorable gradient, sustained by urea absorption from collecting ducts, promotes NaCl absorption. We identified two model modes that produce a significant axial osmolality gradient. One mode, suggested by preliminary immunohistochemical findings, assumes that aquaporin-1-null portions of loops of Henle that reach into the papilla have very low urea permeability. The other mode, suggested by perfused tubule experiments from the literature, assumes that these same portions of loops of Henle have very high urea permeabilities. Model studies were conducted to determine the sensitivity of these modes to parameter choices. Model results are compared with extant tissue-slice and micropuncture studies. renal medulla; urine concentrating mechanism; countercurrent system; sodium chloride transport; urea transport: mathematical model
- Published
- 2004
22. A numerical method for renal models that represent tubules with abrupt changes in membrane properties
- Author
-
Layton, Anita T. and Layton, Harold E.
- Published
- 2002
- Full Text
- View/download PDF
23. Effect of sustained flow perturbations on stability and compensation of tubuloglomerular feedback
- Author
-
Oldson, Darren R., Moore, Leon C., and Layton, Harold E.
- Subjects
Kidneys -- Research ,Biological sciences - Abstract
Oldson, Darren R., Leon C. Moore, and Harold E. Layton. Effect of sustained flow perturbations on stability and compensation of tubuloglomerular feedback. Am J Physiol Renal Physiol 285: F972-F989, 2003. First published July 1, 2003; 10.1152/ajprenal.00377.2002.--A mathematical model previously formulated by us predicts that limit-cycle oscillations (LCO) in nephron flow are mediated by tubuloglomerular feedback (TGF) and that the LCO arise from a bifurcation that depends heavily on the feedback gain magnitude, [gamma], and on its relationship to a theoretically determined critical value of gain, [[gamma].sub.c]. In this study, we used that model to show how sustained perturbations in proximal tubule flow, a common experimental maneuver, can initiate or terminate LCO by changing the values of [gamma] and [[gamma].sub.c], thus changing the sign of [gamma] - [[gamma].sub.c]. This result may help explain experiments in which intratubular pressure oscillations were initiated by the sustained introduction or removal of fluid from the proximal tubule (Leyssac PP and Baumbach L. Acta Physiol Scand 117: 415-419, 1983). In addition, our model predicts that, for a range of TGF sensitivities, sustained perturbations that initiate or terminate LCO can yield substantial and abrupt changes in both distal NaCl delivery and NaCl delivery compensation, changes that may play an important role in the response to physiological challenge. kidney; renal hemodynamics; autoregulation; mathematical model; nonlinear dynamics
- Published
- 2003
24. Advective transport of nitric oxide in a mathematical model of the afferent arteriole
- Author
-
Smith, Kayne M., Moore, Leon C., and Layton, Harold E.
- Subjects
Nitric oxide -- Physiological aspects ,Hemodynamics -- Research ,Biological transport -- Research ,Biological sciences - Abstract
Endothelium-derived nitric oxide (NO) is thought to be short-lived in blood because of rapid removal from plasma, mainly by binding to Hb. The extent to which removal limits NO advection is unclear, especially for blood flow in the renal afferent arteriole (AA), which has a transit time of 3-30 ms. A mathematical model of AA fluid dynamics and myogenic response that includes NO diffusion, advection, degradation, and vasorelaxant action was used to estimate NO advective transport. Model simulations indicate that advective transport of locally produced NO is sufficient to yield physiologically significant NO concentrations along much of the AA. Advective transport is insensitive to NO scavenging by Hb because the NO-Hb binding rate is slow relative to AA transit time. Hence, plasma NO concentration near the vessel wall is influenced by both diffusion from endothelial cells and advection from upstream sites. Simulations also suggest that NO advection may constitute a mechanism to stabilize arteriolar flow in response to a localized vasoconstriction accompanied by enhanced NO release. kidney; renal hemodynamics; myogenic mechanism; immersed boundary method
- Published
- 2003
25. The Urine Concentrating Mechanism and Urea Transporters
- Author
-
Sands, Jeff M., primary and Layton, Harold E., additional
- Published
- 2008
- Full Text
- View/download PDF
26. Contributors
- Author
-
ABBATE, MAURO, primary, ABRAHAMSON, DALE R., additional, ADAMCZAK, MARCIN, additional, ADROGUÉ, HORACIO J., additional, ALPER, SETH L., additional, ALPERN, ROBERT J., additional, ANDREOLI, THOMAS E., additional, APERIA, ANITA C., additional, BAILEY, MATTHEW A., additional, BATLLE, DANIEL, additional, BAUM, MICHEL, additional, BERNDT, THERESA J., additional, BEVENSEE, MARK O., additional, BIBER, JÜRG, additional, BICHET, DANIEL G., additional, BINDELS, RENÉ J.M., additional, BLANTZ, ROLAND C., additional, BORON, WALTER F., additional, BRATER, D. CRAIG, additional, BRIGGS, JOSEPHINE P., additional, BROWN, ALEX, additional, BRUNSKILL, NIGEL J., additional, BURCKHARDT, GERHARD, additional, BURNSTOCK, GEOFFREY, additional, CANTLEY, LLOYD, additional, CAO, CHUNHUA, additional, CAPASSO, GIOVAMBATTISTA, additional, CAPLAN, MICHAEL J., additional, CARROLL, HUGH J., additional, CHAN, LAURENCE, additional, CHUNG-PARK, MOONJA, additional, COE, FREDRIC L., additional, COFFMAN, THOMAS M., additional, COMPER, WAYNE D., additional, CONRAD, KIRK P., additional, CROWLEY, STEVEN D., additional, CURTHOYS, NORMAN P., additional, CUTILLAS, PEDRO R., additional, DANOFF, THEODORE M., additional, DEBNAM, EDWARD S., additional, DIMKE, HENRIK, additional, DOUCET, ALAIN, additional, DUBEY, RAGHVENDRA K., additional, DUSSO, ADRIANA, additional, ECKARDT, KAI-UWE, additional, ELLISON, DAVID H., additional, ENDOU, HITOSHI, additional, ENDRE, ZOLTÁN HUBA, additional, EPSTEIN, FRANKLIN H., additional, EVAN, ANDREW, additional, FALK, RONALD J., additional, FARBAKHSH, KAMBIZ, additional, FERRERI, NICHOLAS R., additional, FONG, PEYING, additional, FONTELES, MANASSES CLAUDINO, additional, FORSTER, IAN, additional, FORTE, LEONARD RALPH, additional, FRANCH, HAROLD A., additional, FRASSETTO, LYNDA A., additional, FRIEDMAN, PETER A., additional, FRØKLÆR, JØRGEN, additional, GEIBEL, JOHN P., additional, GEKLE, MICHAEL, additional, GIEBISCH, GERHARD, additional, GINÈS, PERE, additional, GOLDSTEIN, STEVE A.N., additional, GORAL, SIMIN, additional, GRIFFIN, SIAN V., additional, GUGGINO, WILLIAM B., additional, GUISE, THERESA A., additional, GURLEY, SUSAN B., additional, HALL, STEPHEN D., additional, HALPERIN, MITCHELL L., additional, HAMM, L. LEE, additional, HEBERT, STEVEN C., additional, HEDIGER, MATTHIAS A., additional, HELDERMAN, J. HAROLD, additional, HENRICH, WILLIAM L., additional, HERAS-HERZIG, AILLEEN, additional, HERNANDO, NATI, additional, HOENDEROP, JOOST G.J., additional, HOLTBÄCK, ULLA, additional, HORISBERGER, JEAN-DANIEL, additional, HUMMLER, EDITH, additional, HUNLEY, TRACY E., additional, JACKSON, EDWIN K., additional, JENNETTE, J. CHARLES, additional, JOHNS, EDWARD J., additional, JOHNSON, JOHN P., additional, KAISSLING, BRIGITTE, additional, KAMEL, KAMEL S., additional, KARUMANCHI, S. ANANTH, additional, KASHTAN, CLIFFORD E., additional, KASISKE, BERTRAM L., additional, KATZ, ADRIAN I., additional, KING, BRIAN F., additional, KLAHR, SAULO, additional, KLEYMAN, THOMAS R., additional, KOEPSELL, HERMANN, additional, KON, VALENTINA, additional, KONRAD, MARTIN, additional, KOPP, ULLA C., additional, KRAPF, RETO, additional, KRIZ, WILHELM, additional, KUMAR, RAJIV, additional, KURSCHAT, CHRISTINE E., additional, KURTZ, ARMIN, additional, KWON, TAE-HWAN, additional, LANDOWSKI, CHRISTOPHER P., additional, LANGONE, ANTHONY J., additional, LANG, FLORIAN, additional, LAYTON, HAROLD E., additional, LE, THU H., additional, LEVY, DANIEL I., additional, LIN, SHIH-HUA, additional, LINDHEIMER, MARSHALL D., additional, LU, CHRISTOPHER Y., additional, MADAIO, MICHAEL P., additional, MADIAS, NICOLAOS E., additional, MALNIC, GERHARD, additional, MATLIN, KARL S., additional, McCLELLAN, WILLIAM C., additional, MCGIFF, JOHN C., additional, MICHEL, C. CHARLES, additional, MINER, JEFFREY H., additional, MITCH, WILLIAM E., additional, MIYAZAKI, HIROKI, additional, MOE, ORSON W., additional, MOLITORIS, BRUCE A., additional, MORRIS, R. CURTIS, additional, MUJAIS, SALIM K., additional, MURER, HEINI, additional, MUTO, SHIGEAKI, additional, NATTIE, EUGENE, additional, NEILSON, ERIC G., additional, NIELSEN, SØREN, additional, NIGAM, SANJAY K., additional, NOGUEIRA, JOSEPH M., additional, OH, MAN S., additional, OKUSA, MARK D., additional, OSICKA, TANYA M., additional, PALLONE, THOMAS L., additional, PALMER, BIFF F., additional, PALMER, LAWRENCE G., additional, PARKER, MARK D., additional, PARKS, JOAN H., additional, PREISIG, PATRICIA A., additional, QUAMME, GARY A., additional, QUARLES, L. DARRYL, additional, QUIGLEY, RAYMOND, additional, REEVES, W. BRIAN, additional, REMUZZI, GIUSEPPE, additional, REUSS, LUIS, additional, RICCARDI, DANIELA, additional, RINGHOFER, BRIAN, additional, RITZ, EBERHARD, additional, RIVARD, CHRISTOPHER J., additional, ROBERTSON, GARY L., additional, ROSA, ROBERT M., additional, ROSSIER, BERNARD C., additional, RUSSO, LEILEATA M., additional, SACKIN, HENRY, additional, SAKURAI, HIROYUKI, additional, SANDS, JEFF M., additional, SATLIN, LISA M., additional, SCHAEFER, HEIDI, additional, SCHELLING, JEFFREY R., additional, SCHILD, LAURENT, additional, SCHLINGMANN, KARL P., additional, SCHNERMANN, JÜRGEN B., additional, SCHRIER, ROBERT W., additional, SEBASTIAN, ANTHONY, additional, SEDOR, JOHN R., additional, SEGAL, YOAV, additional, SEKINE, TAKASHI, additional, SELDIN, DONALD W., additional, SENITKO, MARTIN, additional, SHAH, MALATHI, additional, SHAH, SUDHIR V., additional, SHANKLAND, STUART J., additional, SHARFUDDIN, ASIF A., additional, SHARMA, KUMAR, additional, SHENG, SHAOHU, additional, SHIRLEY, DAVID G., additional, SILBERNAGL, STEFAN, additional, SILVER, STEPHEN M., additional, SILVERMAN, MEL, additional, SLATOPOLSKY, EDUARDO, additional, SOMLO, STEFAN, additional, STERNS, RICHARD H., additional, STEWART, ANDREW K., additional, SUZUKI, YOSHIRO, additional, TEBBEN, PETER J., additional, THOMSON, SCOTT C., additional, TORRES, VICENTE E., additional, UNWIN, ROBERT J., additional, VERREY, FRANÇOIS, additional, VESELY, DAVID L., additional, WAGNER, CARSTEN A., additional, WALDMAN, MERYL, additional, WALKER, ROBERT JAMES, additional, WANG, WEI, additional, WANG, WEN-HUI, additional, WANG, YINGHONG, additional, WEINSTEIN, ALAN M., additional, WELLING, PAUL A., additional, WOLF, GUNTER, additional, WORCESTER, ELAINE, additional, ZIYADEH, FUAD N., additional, and ZOJA, CARLA, additional
- Published
- 2008
- Full Text
- View/download PDF
27. Mathematical Models of the Mammalian Urine Concentrating Mechanism
- Author
-
Layton, Harold E., primary
- Published
- 2002
- Full Text
- View/download PDF
28. A Reduced Model for Nephron Flow Dynamics Mediated by Tubuloglomerular Feedback
- Author
-
Pitman, E. Bruce, primary, Zaritski, Roman M., additional, Moore, Leon C., additional, and Layton, Harold E., additional
- Published
- 2002
- Full Text
- View/download PDF
29. A computational model of epithelial solute and water transport along a human nephron
- Author
-
Layton, Anita T., primary and Layton, Harold E., additional
- Published
- 2019
- Full Text
- View/download PDF
30. Functional implications of sexual dimorphism of transporter patterns along the rat proximal tubule: modeling and analysis
- Author
-
Li, Qianyi, primary, McDonough, Alicia A., additional, Layton, Harold E., additional, and Layton, Anita T., additional
- Published
- 2018
- Full Text
- View/download PDF
31. Contributors
- Author
-
Advani, Andrew, Alexander, Todd, Allon, Michael, Appel, Gerald B., Assady, Suheir, Baigent, Colin, Bakris, George L., Battistella, Marisa, Beddhu, Srinivasan, Bello, Aminu K., Berndt, Theresa J., Bertram, John F., Bhalla, Vivek, Bichet, Daniel G., Bikbov, Boris, Bockenhauer, Detlef, Bonnardeaux, Alain, Bouchard, Josée, Breyer, Richard M., Broer, Stefan, Brugnara, Carlo, Butler, Catherine R., Cardinal, Héloise, Carrero, Juan Jesús, Cattran, Daniel C., Chan, Tak Mao Daniel, Chang, Tara I., Chertow, Glenn M., Chin, Andrew A., Cho, Yeoungjee, Chonchol, Michel, Christov, Marta, Clapp, William L., Cohen, Rachel Becker, Connelly, Kelsey, Cook, H. Terence, Coresh, Josef, Correa-Rotter, Ricardo, Cowper, Shawn E., D'Agati, Vivette D., Damman, Kevin, Davids, Mogamat Razeen, Davison, Sara, Denic, Aleksander, Denker, Bradley M., Depner, Thomas A., DuBose, Thomas D., Jr., Duddalwar, Vinay A., Eckardt, Kai-Uwe, Elliott, William J., Ellison, David H., Falk, Ronald J., Fenton, Robert Andrew, Fornoni, Alessia, Freedman, Benjamin S., Frishberg, Yaacov, Frøkiaer, Jørgen, Funder, John W., Garg, Amit X., Ghannoum, Marc, Gharbi, Mohammed Benghanem, Gilbert, Richard E., Glassock, Richard J., Goraya, Nimrit, Grams, Morgan E., Groop, Per Henrik, Habbous, Steven, Hall, Yoshio N., Halperin, Mitchell L., Hamm, L. Lee, Harris, Peter C., Harris, Raymond C., Haynes, Richard, Hébert, Marie Josée, Herrington, William G., Hoorn, Ewout J., Hostetter, Thomas H., Hu, Susie L., Huber, Tobias B., Jadvar, Hossein, Jaimes, Edgar A., Jassal, Sarbjit Vanita, Jennette, J. Charles, Johnson, David W., Kamel, Kamel S., Karumanchi, S. Ananth, Kavanagh, David, Keller, Frieder, Ko, Christine J., Kohli, Harbir Singh, Koyner, Jay L., Kreidberg, Jordan, Krishnan, Anoushka, Kumar, Rajiv, Lafreniere, Gabrielle, Lam, Ngan N., Landray, Martin J., Layton, Harold E., Lee, Timmy, Lenihan, Colin R., Lentine, Krista L., Levey, Andrew S., Levin, Adeera, Licht, Christoph, Lindholm, Bengt, Liu, Kathleen, Luyckx, Valérie A., Maddox, David A., Maezawa, Yoshiro, Matzke, Gary R., Maya, Ivan D., Maynard, Sharon E., McCormick, James A., McDonough, Alicia Ann, McMurray, John J.V., Mehrotra, Rajnish, Meyer, Timothy W., Meyer-Schwesinger, Catherine, Moe, Orson W., Moritz, Karen M., Moss, Alvin H., Mount, David B., Munger, Karen A., Najafian, Behzad, Navar, Luis Gabriel, Nelson, Robert G., Nicolle, Lindsay E., Nigam, Sanjay K., Okusa, Mark Douglas, Palevsky, Paul M., Palmer, Suetonia C., Palmer, Suzanne L., Parikh, Chirag R., Pearce, David, Peixoto, Aldo J., Pendergraft, William F., III, Perazella, Mark A., Perico, Norberto, Pollak, Martin R., Portilla, Didier, Quaggin, Susan E., Radhakrishnan, Jai, Ramadan, Rawi, Reich, Heather N., Remuzzi, Andrea, Remuzzi, Giuseppe, Riella, Leonardo V., Riella, Miquel C., Rinat, Choni, III, Roberts, Darren M., Rosenblum, Norman D., Rosner, Mitchell H., Rule, Andrew D., Sabath, Ernesto, Saha, Manish K., Sakhaee, Khashayar, Sakhuja, Vinay, Salama, Alan D., Sands, Jeff M., Saxena, Anjali Bhatt, Schlöndorff, Johannes, Scott, Rizaldy Paz, Sheerin, Neil, Singh, Prableen, Skorecki, Karl, Slotki, Itzchak N., Smogorzewski, Miroslaw J., Smoyer, William E., Sprague, Stuart M., Stenvinkel, Peter, Stubbs, Jason R., Taal, Maarten W., Tamura, Manjula Kurella, Tan, Jane C., Tangri, Navdeep, Textor, Stephen C., Thadhani, Ravi I., Thomson, Scott Culver, Tinckam, Kathryn, Torres, Vicente E., Vallon, Volker, Verbalis, Joseph G., Verlander, Jill W., Wald, Ron, Weiner, I. David, Weisbord, Steven D., Weiss, Robert H., Wesson, Donald Everett, Wheeler, David C., Wilcox, Christopher S., Yeun, Jane Y., Young, Brian, Yu, Alan S.L., and Zhang, Ming-Zhi
- Published
- 2020
- Full Text
- View/download PDF
32. Heterodyning in Tubuloglomerular Feedback Induced Oscillations in Coupled Model Nephrons
- Author
-
Kesseler, Kevin J., primary and Layton, Harold E., additional
- Published
- 2016
- Full Text
- View/download PDF
33. Functional implications of sexual dimorphism of transporter patterns along the rat proximal tubule: modeling and analysis.
- Author
-
Qianyi Li, McDonough, Alicia A., Layton, Harold E., and Layton, Anita T.
- Abstract
The goal of this study is to investigate the functional implications of the sexual dimorphism in transporter patterns along the proximal tubule. To do so, we have developed sex-specific computational models of solute and water transport in the proximal convoluted tubule of the rat kidney. The models account for the sex differences in expression levels of the apical and basolateral transporters, in single-nephron glomerular filtration rate, and in tubular dimensions. Model simulations predict that 70.6 and 38.7% of the filtered volume is reabsorbed by the proximal tubule of the male and female rat kidneys, respectively. The lower fractional volume reabsorption in females can be attributed to their smaller transport area and lower aquaporin-1 expression level. The latter also results in a larger contribution of the paracellular pathway to water transport. Correspondingly similar fractions (70.9 and 39.2%) of the filtered Na are reabsorbed by the male and female proximal tubule models, respectively. The lower fractional Na reabsorption in females is due primarily to their smaller transport area and lower Na
+ /H+ exchanger isoform 3 and claudin-2 expression levels. Notably, unlike most Na+ transporters, whose expression levels are lower in females, Na- glucose cotransporter 2 (SGLT2) expression levels are 2.5-fold higher in females. Model simulations suggest that the higher SGLT2 expression in females may compensate for their lower tubular transport area to achieve a hyperglycemic tolerance similar to that of males. [ABSTRACT FROM AUTHOR]- Published
- 2018
- Full Text
- View/download PDF
34. Chapter 43 - The Urine Concentrating Mechanism and Urea Transporters
- Author
-
Sands, Jeff M. and Layton, Harold E.
- Published
- 2012
- Full Text
- View/download PDF
35. Towards a web resource for quantitative renal physiology
- Author
-
Thomas, S. Randall, Layton, Harold E., Layton, Anita T., Harris, Peter, Lonie, Andrew, Moore, Leon C., Informatique, Biologie Intégrative et Systèmes Complexes (IBISC), Université d'Évry-Val-d'Essonne (UEVE)-Centre National de la Recherche Scientifique (CNRS), Department mathematics, Duke University [Durham], Department of Computer Science and Software Engineering (CCSE), University of Melbourne, Department Physiology, Stony Brook University [SUNY] (SBU), State University of New York (SUNY)-State University of New York (SUNY), and Davesne, Frédéric
- Subjects
[SDV.BIBS] Life Sciences [q-bio]/Quantitative Methods [q-bio.QM] ,[INFO.INFO-GT]Computer Science [cs]/Computer Science and Game Theory [cs.GT] ,[SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] ,[SCCO.COMP]Cognitive science/Computer science ,[SDV.BC.IC] Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB] ,[SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology ,[SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM] ,[INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation ,[SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology ,[SCCO.COMP] Cognitive science/Computer science ,[SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB] ,[INFO.INFO-GT] Computer Science [cs]/Computer Science and Game Theory [cs.GT] ,[SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] ,[INFO.INFO-MO] Computer Science [cs]/Modeling and Simulation ,[INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM] ,[INFO.INFO-BI] Computer Science [cs]/Bioinformatics [q-bio.QM] - Abstract
International audience; We present a two-pronged project: 1) a Quantitative Kidney DataBase (QKDB), and 2) an interactive website presenting a coherent and comprehensive set of mathematical models covering the major aspects of renal physiology. 1. The QKDB will contain the data needed for quantitative evaluation of hypotheses of renal function, from the cellular, through the epithelial and tubular, to whole organ levels. It will thus put legacy measurements, as well as recent and new data, at the ready disposal of renal researchers, facilitating comparisons among different species and under various experimental conditions. It will include especially (list to be extended as needed): transport parameters, tubular concentrations and flow rates along the various nephron segments, and anatomical details, in human kidneys, in experimentally studied species, and in model epithelia such as cultured cells and amphibian skin and urinary bladder. 2. The modeling resource, a dynamic website, will be grounded in the experience of the project participants, all of whom are established modelers of kidney physiology. The site will provide an interactive user interface to a collection of published models at all levels of renal physiology, thus enabling non-modelers to interactively exploit the models, altering the key parameters according to hypotheses of their own and visualizing the simulation results, thus permitting quantitative exploration of new hypotheses. The site will include all existing types of models relevant to renal physiology, including kinetic models of transporters and channels, transport models of individual cell types, of flat model epithelia (such as bladder and cultured epithelia), and of tubular segments along the nephron, models of the microcirculation, models of tubuloglomerular feedback, and models of inner and outer medulla at various levels of detail. Implementation of the web resource will be facilitated by translation of the models into a common markup language (such as CellML and SBML). There will thus be a modular separation of model descriptions from their numerical solution methods. This two-pronged web resource, by leveraging the efforts of the community of renal modelers and thus facilitating general access to hypothesis-driven modeling, will enhance the evaluation of new hypotheses in renal physiology and the effects of disease-related defects of transport proteins, renal metabolism, and anatomical features. The development strategy will use, as far as possible, a generic approach so that conversion of this effort for application to other organ systems will be straightforward.
- Published
- 2005
36. Urine-Concentrating Mechanism in the Inner Medulla
- Author
-
Dantzler, William H., primary, Layton, Anita T., additional, Layton, Harold E., additional, and Pannabecker, Thomas L., additional
- Published
- 2014
- Full Text
- View/download PDF
37. Advances in Understanding the Urine-Concentrating Mechanism
- Author
-
Sands, Jeff M., primary and Layton, Harold E., additional
- Published
- 2014
- Full Text
- View/download PDF
38. Transport efficiency and workload distribution in a mathematical model of the thick ascending limb
- Author
-
Nieves-González, Aniel, primary, Clausen, Chris, additional, Layton, Anita T., additional, Layton, Harold E., additional, and Moore, Leon C., additional
- Published
- 2013
- Full Text
- View/download PDF
39. Fluid dilution and efficiency of Na+ transport in a mathematical model of a thick ascending limb cell
- Author
-
Nieves-González, Aniel, primary, Clausen, Chris, additional, Marcano, Mariano, additional, Layton, Anita T., additional, Layton, Harold E., additional, and Moore, Leon C., additional
- Published
- 2013
- Full Text
- View/download PDF
40. Signal transduction in a compliant thick ascending limb
- Author
-
Layton, Anita T., primary, Moore, Leon C., additional, and Layton, Harold E., additional
- Published
- 2012
- Full Text
- View/download PDF
41. Countercurrent multiplication may not explain the axial osmolality gradient in the outer medulla of the rat kidney
- Author
-
Layton, Anita T., primary and Layton, Harold E., additional
- Published
- 2011
- Full Text
- View/download PDF
42. Feedback-mediated dynamics in a model of coupled nephrons with compliant thick ascending limbs
- Author
-
Layton, Anita T., primary, Bowen, Matthew, additional, Wen, Amy, additional, and Layton, Harold E., additional
- Published
- 2011
- Full Text
- View/download PDF
43. Dynamical Properties of the Thick Ascending Limb (TAL): A Modeling Study
- Author
-
Nieves‐Gonzalez, Aniel, primary, Clausen, Chris, additional, Layton, Harold E, additional, Layton, Anita T, additional, and Moore, Leon C, additional
- Published
- 2011
- Full Text
- View/download PDF
44. Efficiency of sodium transport in a model of the Thick Ascending Limb (TAL)
- Author
-
Nieves‐Gonzalez, Aniel, primary, Clausen, Chris, additional, Marcano, Mariano, additional, Layton, Harold E, additional, Layton, Anita T, additional, and Moore, Leon C, additional
- Published
- 2011
- Full Text
- View/download PDF
45. A mathematical model of the myogenic response to systolic pressure in the afferent arteriole
- Author
-
Chen, Jing, primary, Sgouralis, Ioannis, additional, Moore, Leon C., additional, Layton, Harold E., additional, and Layton, Anita T., additional
- Published
- 2011
- Full Text
- View/download PDF
46. Efficiency of sodium transport in the thick ascending limb
- Author
-
Nieves‐Gonzalez, Aniel, primary, Moore, Leon C, additional, Clausen, Chris, additional, Marcano, Mariano, additional, Layton, Harold E, additional, and Layton, Anita T, additional
- Published
- 2010
- Full Text
- View/download PDF
47. A mathematical model of the afferent arteriolar smooth muscle cell
- Author
-
Layton, Harold E, primary, Chen, Jing, additional, Moore, Leon C, additional, and Layton, Anita T, additional
- Published
- 2010
- Full Text
- View/download PDF
48. Maximum Urine Concentrating Capability in a Mathematical Model of the Inner Medulla of the Rat Kidney
- Author
-
Marcano, Mariano, primary, Layton, Anita T., additional, and Layton, Harold E., additional
- Published
- 2009
- Full Text
- View/download PDF
49. The Mammalian Urine Concentrating Mechanism: Hypotheses and Uncertainties
- Author
-
Layton, Anita T., primary, Layton, Harold E., additional, Dantzler, William H., additional, and Pannabecker, Thomas L., additional
- Published
- 2009
- Full Text
- View/download PDF
50. Estimation of Acid‐Base and NH + 4 Transport Parameters in a TAL Cell Model Using Inverse Methods
- Author
-
Nieves‐Gonzalez, Aniel, primary, Marcano, Mariano, additional, Clausen, Chris, additional, Layton, Harold E., additional, and Moore, Leon C., additional
- Published
- 2009
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.