5 results on '"Lawton D, Murdolo"'
Search Results
2. Ablation of CD8+ T cell recognition of an immunodominant epitope in SARS-CoV-2 Omicron variants BA.1, BA.2 and BA.3
- Author
-
Srividhya Swaminathan, Katie E. Lineburg, Archana Panikkar, Jyothy Raju, Lawton D. Murdolo, Christopher Szeto, Pauline Crooks, Laetitia Le Texier, Sweera Rehan, Michael J. Dewar-Oldis, Peter J. Barnard, George R. Ambalathingal, Michelle A. Neller, Kirsty R. Short, Stephanie Gras, Rajiv Khanna, and Corey Smith
- Subjects
Multidisciplinary ,General Physics and Astronomy ,General Chemistry ,General Biochemistry, Genetics and Molecular Biology ,Uncategorized - Abstract
The emergence of the SARS-CoV-2 Omicron variant has raised concerns of escape from vaccine-induced immunity. A number of studies have demonstrated a reduction in antibody-mediated neutralization of the Omicron variant in vaccinated individuals. Preliminary observations have suggested that T cells are less likely to be affected by changes in Omicron. However, the complexity of human leukocyte antigen genetics and its impact upon immunodominant T cell epitope selection suggests that the maintenance of T cell immunity may not be universal. In this study, we describe the impact that changes in Omicron BA.1, BA.2 and BA.3 have on recognition by spike-specific T cells. These T cells constitute the immunodominant CD8+ T cell response in HLA-A*29:02+ COVID-19 convalescent and vaccinated individuals; however, they fail to recognize the Omicron-encoded sequence. These observations demonstrate that in addition to evasion of antibody-mediated immunity, changes in Omicron variants can also lead to evasion of recognition by immunodominant T cell responses.
- Published
- 2023
- Full Text
- View/download PDF
3. Ablation of CD8
- Author
-
Srividhya, Swaminathan, Katie E, Lineburg, Archana, Panikkar, Jyothy, Raju, Lawton D, Murdolo, Christopher, Szeto, Pauline, Crooks, Laetitia, Le Texier, Sweera, Rehan, Michael J, Dewar-Oldis, Peter J, Barnard, George R, Ambalathingal, Michelle A, Neller, Kirsty R, Short, Stephanie, Gras, Rajiv, Khanna, and Corey, Smith
- Subjects
Immunodominant Epitopes ,SARS-CoV-2 ,Spike Glycoprotein, Coronavirus ,Humans ,COVID-19 ,CD8-Positive T-Lymphocytes ,Antibodies, Viral ,Antibodies, Neutralizing - Abstract
The emergence of the SARS-CoV-2 Omicron variant has raised concerns of escape from vaccine-induced immunity. A number of studies have demonstrated a reduction in antibody-mediated neutralization of the Omicron variant in vaccinated individuals. Preliminary observations have suggested that T cells are less likely to be affected by changes in Omicron. However, the complexity of human leukocyte antigen genetics and its impact upon immunodominant T cell epitope selection suggests that the maintenance of T cell immunity may not be universal. In this study, we describe the impact that changes in Omicron BA.1, BA.2 and BA.3 have on recognition by spike-specific T cells. These T cells constitute the immunodominant CD8
- Published
- 2022
4. COVID-19 vaccine booster induces a strong CD8+ T cell response against Omicron variant epitopes in HLA-A*02:01+ individuals
- Author
-
Andrea T. Nguyen, Christopher Szeto, Demetra S.M. Chatzileontiadou, Zhen Wei Marcus Tong, Michael J. Dewar-Oldis, Lucy Cooper, Lawton D. Murdolo, Keng Yih Chew, Katie E. Lineburg, Alan Riboldi-Tunicliffe, Rachel Williamson, Bradley J. Gardiner, Dhilshan Jayasinghe, Christian A. Lobos, You Min Ahn, Emma J. Grant, Corey Smith, James McMahon, Kim L. Good-Jacobson, Peter J. Barnard, Kirsty R. Short, and Stephanie Gras
- Abstract
The >30 mutated residues in the Omicron spike protein have led to its rapid classification as a new SARS-CoV-2 variant of concern. As a result, Omicron may escape from the immune system, decreasing the protection provided by COVID-19 vaccines. Preliminary data shows a weaker neutralizing antibody response to Omicron compared to the ancestral SARS-CoV-2 virus, which can be increased after a booster vaccine. Here, we report that CD8+ T cells can recognize Omicron variant epitopes presented by HLA-A*02:01 in both COVID-19 recovered and vaccinated individuals, even 6 months after infection or vaccination. Additionally, the T cell response was stronger for Omicron variant epitopes after the vaccine booster. Altogether, T cells can recognize Omicron variants, especially in vaccinated individuals after the vaccine booster.One-Sentence SummaryCD8+ T cells response against Omicron variant epitopes is stronger after the vaccine booster.
- Published
- 2022
5. A common allele of HLA mediates asymptomatic SARS-CoV-2 infection
- Author
-
Danillo G. Augusto, Tasneem Yusufali, Joseph J. Sabatino, Noah D. Peyser, Lawton D. Murdolo, Xochitl Butcher, Victoria Murray, Vivian Pae, Sannidhi Sarvadhavabhatla, Fiona Beltran, Gurjot Gill, Kara Lynch, Cassandra Yun, Colin Maguire, Michael J. Peluso, Rebecca Hoh, Timothy J. Henrich, Steven G. Deeks, Michelle Davidson, Scott Lu, Sarah A. Goldberg, J. Daniel Kelly, Jeffrey N. Martin, Cynthia A. Viera-Green, Stephen R. Spellman, David J. Langton, Sulggi Lee, Gregory M. Marcus, Jeffrey E. Olgin, Mark J. Pletcher, Stephanie Gras, Martin Maiers, and Jill A. Hollenbach
- Subjects
Immune system ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Cohort ,Immunology ,medicine ,Human leukocyte antigen ,Disease ,Allele ,medicine.symptom ,business ,Asymptomatic ,HLA-B - Abstract
Despite some inconsistent reporting of symptoms, studies have demonstrated that at least 20% of individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) will remain asymptomatic. Although most global efforts have focused on understanding factors underlying severe illness in COVID-19 (coronavirus disease of 2019), the examination of asymptomatic infection provides a unique opportunity to consider early disease and immunologic features promoting rapid viral clearance. Owing to its critical role in the immune response, we postulated that variation in the human leukocyte antigen (HLA) loci may underly processes mediating asymptomatic infection. We enrolled 29,947 individuals registered in the National Marrow Donor Program for whom high-resolution HLA genotyping data were available in the UCSF Citizen Science smartphone-based study designed to track COVID-19 symptoms and outcomes. Our discovery cohort (n=1428) was comprised of unvaccinated, self-identified subjects who reported a positive test result for SARS-CoV-2. We tested for association of five HLA loci (HLA-A, -B, -C, -DRB1, -DQB1) with disease course and identified a strong association of HLA-B*15:01 with asymptomatic infection, and reproduced this association in two independent cohorts. Suggesting that this genetic association is due to pre-existing T-cell immunity, we show that T cells from pre-pandemic individuals carrying HLA-B*15:01 were reactive to the immunodominant SARS-CoV-2 S-derived peptide NQKLIANQF, and 100% of the reactive cells displayed memory phenotype. Finally, we characterize the protein structure of HLA-B*15:01-peptide complexes, demonstrating that the NQKLIANQF peptide from SARS-CoV-2, and the highly homologous NQKLIANAF from seasonal coronaviruses OC43-CoV and HKU1-CoV, share similar ability to be stabilized and presented by HLA-B*15:01, providing the molecular basis for T-cell cross-reactivity and HLA-B*15:01-mediated pre-existing immunity.
- Published
- 2021
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.