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298 results on '"Lawrie, Theresa A"'

8. Prepregnancy and Early Pregnancy Calcium Supplementation Among Women at High Risk of Pre-eclampsia: A Multicentre, Double-blind, Randomised, Placebo-Controlled Trial

Author

Hofmeyr, G. Justus, Betrán, Ana Pilar, Singata-Madliki, Mandisa, Cormick, Gabriela, Munjanja, Stephen P., Fawcus, Susan, Mose, Simpiwe, Hall, David, Ciganda, Alvaro, Seuc, Armando H., Lawrie, Theresa A., Bergel, Eduardo, Roberts, James M., von Dadelszen, Peter, and Belizán, José M.

Published
2019
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13. The Novelty of mRNA Vaccines and Potential Harms: A Scoping Review

Author

Halma, Matthew, Rose, Jessica, Jenks, Alan, and Lawrie, Theresa

Subjects
immunology
Abstract

Pharmacovigilance databases are showing evidence of injury in the context of the COVID-19 modified mRNA shots. According to recent publications, adverse event reports linked to the mRNA COVID-19 products largely point to the spike protein as an aetiological agent of adverse events, but we propose that the platform itself may be culpable. To assess the safety of current and future mRNA vaccines, further analysis on the risks due to the platform itself, and not specifically the expressed antigen. If harm can be exclusively and conclusively attributed to the spike protein, then it is possible that future mRNA vaccines expressing other antigens will be safe. If harms are attributable to the platform itself, then regardless of the toxicity, or lack thereof, of the chosen payload therein, the platform may be inherently unsafe, pending modification. In this work, we examine previous studies of RNA-based delivery by a lipid nanoparticle and break down the possible etiological elements of harm.

Published
2023

15. Interventions to Reduce Maternal and Newborn Morbidity and Mortality

Author

Gülmezoglu, A. Metin, primary, Lawrie, Theresa A., additional, Hezelgrave, Natasha, additional, Oladapo, Olufemi T., additional, Souza, João Paulo, additional, Gielen, Marijke, additional, Lawn, Joy E., additional, Bahl, Rajiv, additional, Althabe, Fernando, additional, Colaci, Daniela, additional, and Hofmeyr, G. Justus, additional

Published
2016
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30. Interventions to reduce the time to diagnosis of brain tumours

Author

Grant, Robin, additional, Dowswell, Therese, additional, Tomlinson, Eve, additional, Brennan, Paul M, additional, Walter, Fiona M, additional, Ben-Shlomo, Yoav, additional, Hunt, David William, additional, Bulbeck, Helen, additional, Kernohan, Ashleigh, additional, Robinson, Tomos, additional, and Lawrie, Theresa A, additional

Published
2020
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35. Prepregnancy and early pregnancy calcium supplementation among women at high risk of pre-eclampsia: a multicentre, double-blind, randomised, placebo-controlled trial

Author

Hofmeyr, G Justus, primary, Betrán, Ana Pilar, additional, Singata-Madliki, Mandisa, additional, Cormick, Gabriela, additional, Munjanja, Stephen P, additional, Fawcus, Susan, additional, Mose, Simpiwe, additional, Hall, David, additional, Ciganda, Alvaro, additional, Seuc, Armando H, additional, Lawrie, Theresa A, additional, Bergel, Eduardo, additional, Roberts, James M, additional, von Dadelszen, Peter, additional, Belizán, José M, additional, Althabe, Fernando, additional, Sawchuck, Diane, additional, Vidler, Marianne, additional, Allie, Saadiqa, additional, Anthony, John, additional, Frank, Karlyn, additional, de Greeff, Annmarie, additional, Fawcus, Sue, additional, Hofmeyr, Justus, additional, Kovane, Mvuseleli, additional, Kovane, Patience, additional, Lawrie, Theresa, additional, Mshweshwe, Nolundi, additional, Mqikela, Velisa, additional, Njikelana, Pamela, additional, Novikova, Natalia, additional, Oyebajo, Adegboyega, additional, Parker, Catherine, additional, Phuti, Angel, additional, van Papendorp, Erika, additional, Williams, Xoliswa, additional, Dannemann, Tina, additional, Seuc, Armando, additional, Magee, Laura, additional, Donnay, France, additional, Drebit, Sharla, additional, Roberts, Jim, additional, Guzha, Bothwell, additional, Makaza, Emilia, additional, Manyame, Sarah, additional, Munjanja, Stephen, additional, and Tahuringana, Eunice, additional

Published
2019
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38. Qualitative Evidence Synthesis (QES) for Guidelines: Paper 2 – Using qualitative evidence synthesis findings to inform evidence-to-decision frameworks and recommendations

Author

Lewin, Simon A, Glenton, Claire, Lawrie, Theresa A, Downe, Soo, Finlayson, Kenneth William, Rosenbaum, Sarah, Barreix, Maria, Tuncalp, Ozge, Lewin, Simon A, Glenton, Claire, Lawrie, Theresa A, Downe, Soo, Finlayson, Kenneth William, Rosenbaum, Sarah, Barreix, Maria, and Tuncalp, Ozge

Abstract

Background: WHO has recognised the need to improve its guideline methodology to ensure that guideline decision-making processes are transparent and evidence based, and that the resulting recommendations are relevant and applicable. To help achieve this, WHO guidelines now typically enhance intervention effectiveness data with evidence on a wider range of decision-making criteria, including how stakeholders value different outcomes, equity, gender and human rights impacts, and the acceptability and feasibility of interventions. Qualitative evidence syntheses (QES) are increasingly used to provide evidence on this wider range of issues. In this paper, we describe and discuss how to use the findings from QES to populate decision-making criteria in evidence-to-decision (EtD) frameworks. This is the second in a series of three papers that examines the use of QES in developing clinical and health system guidelines. Methods: WHO convened a writing group drawn from the technical teams involved in its recent (2010–2018) guidelines employing QES. Using a pragmatic and iterative approach that included feedback from WHO staff and other stakeholders, the group reflected on, discussed and identified key methods and research implications from designing QES and using the resulting findings in guideline development. Results: We describe a step-wise approach to populating EtD frameworks with QES findings. This involves allocating findings to the different EtD criteria (how stakeholders value different outcomes, equity, acceptability and feasibility, etc.), weaving the findings into a short narrative relevant to each criterion, and inserting this summary narrative into the corresponding ‘research evidence’ sections of the EtD. We also identify areas for further methodological research, including how best to summarise and present qualitative data to groups developing guidelines, how these groups draw on different types of evidence in their decisions, and the extent to which our experie

Published
2019

42. Robot-assisted surgery in gynaecology

Author

Lawrie, Theresa A, primary, Liu, Hongqian, additional, Lu, DongHao, additional, Dowswell, Therese, additional, Song, Huan, additional, Wang, Lei, additional, and Shi, Gang, additional

Published
2019
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44. Psychological, behavioural and physiological effects of three long-acting reversible contraception (LARC) methods: protocol for an ancillary study of the ECHO randomised trial

Author

Singata-Madliki, Mandisa, Hofmeyr, G Justus, Carayon-Lefebvre d’Hellencourt, Florence, and Lawrie, Theresa Anne

Subjects
Adult, Long-Acting Reversible Contraception, Adolescent, Depression, Pregnancy, Unplanned, Levonorgestrel, Medroxyprogesterone Acetate, intrauterine device, Intrauterine Devices, Copper, Sexual Dysfunction, Physiological, South Africa, Young Adult, contraception, Dysmenorrhea, sexual dysfunction, Pregnancy, Research Design, long-acting progestogen, Obstetrics and Gynaecology, London, Protocol, Humans, Female
Abstract

Introduction This is the protocol for an ancillary study to the multicentre Evidence for Contraceptive Options and HIV Outcomes (ECHO) Trial, a three-arm randomised trial comparing the effects of depot medroxyprogesterone acetate (DMPA), the levonorgestrel (LNG) implant and the copper intrauterine device (IUD) on HIV incidence (NCT02550067 pre-results). The ancillary study will compare other non-contraceptive effects of these three long-acting, reversible contraceptions about which there is little existing comparative evidence. Methods and analysis Women randomised to IUD, DMPA and LNG implant (1:1:1) at one of the ECHO trial sites will be asked to participate in the ancillary study at the 1-month follow-up visit. Research staff will interview women that consent to participate at the 3-month follow-up visit. Primary outcomes are depression, sexual dysfunction and menstrual disturbances. The Beck Depression Inventory will be used to assess depression and the Arizona Sexual Experiences Scale to assess sexual dysfunction. Participants will also be asked to prospectively complete a 28-day symptom diary. The required sample size is 522 participants. Depression scores will be analysed as continuous and categorical variables. Analysis will be by intention to treat. Ethics and dissemination The ancillary study protocol received ethical approval from the University of the Witwatersrand Committee for Research on Human Subjects on 17 February 2016 (reference no. 14112). The results will be disseminated in a peer-reviewed open-access journal. Trial registration number PACTR201706001651380.

Published
2017

45. Effectiveness of respectful care policies for women using routine intrapartum services: a systematic review

Author

Downe, Soo, Lawrie, Theresa A, Finlayson, Kenneth William, Oladapo, Olufemi T, Downe, Soo, Lawrie, Theresa A, Finlayson, Kenneth William, and Oladapo, Olufemi T

Abstract

Several studies have identified how mistreatment during labour and childbirth can act as a barrier to the use of health facilities. Despite general agreement that respectful maternity care (RMC) is a fundamental human right, and an important component of quality intrapartum care that every pregnant woman should receive, the effectiveness of proposed policies remains uncertain. We performed a systematic review to assess the effectiveness of introducing RMC policies into health facilities providing intrapartum services. We included randomized and non-randomized controlled studies evaluating the effectiveness of introducing RMC policies into health facilities. We searched PubMed, CINAHL, LILACS, AJOL, WHO RHL, and Popline, along with ongoing trials registers (ISRCT register, ICTRP register), and the White Ribbon Respectful Maternity Care Repository. Included studies were assessed for risk of bias. Certainty of evidence was assessed using GRADE criteria. Five studies were included. All were undertaken in Africa (Kenya, Tanzania, Sudan, South Africa), and involved a range of components. Two were cluster RCTs, and three were before/after studies. In total, over 8000 women were included at baseline and over 7500 at the endpoints. Moderate certainty evidence suggested that RMC interventions increases women's experiences of respectful care (one cRCT, approx. 3000 participants; adjusted odds ratio (aOR) 3.44, 95% CI 2.45-4.84); two observational studies also reported positive changes. Reports of good quality care increased. Experiences of disrespectful or abusive care, and, specifically, physical abuse, were reduced. Low certainty evidence indicated fewer accounts of non-dignified care, lack of privacy, verbal abuse, neglect and abandonment with RMC interventions, but no difference in satisfaction rates. Other than low certainty evidence of reduced episiotomy rates, there were no data on the pre-specified clinical outcomes. Multi-component RMC policies appear to reduce women'

Published
2018

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