274 results on '"Lawrie, Alison"'
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2. Safety of a controlled human infection model of tuberculosis with aerosolised, live-attenuated Mycobacterium bovis BCG versus intradermal BCG in BCG-naive adults in the UK: a dose-escalation, randomised, controlled, phase 1 trial
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Satti, Iman, Marshall, Julia L, Harris, Stephanie A, Wittenberg, Rachel, Tanner, Rachel, Lopez Ramon, Raquel, Wilkie, Morven, Ramos Lopez, Fernando, Riste, Michael, Wright, Daniel, Peralta Alvarez, Marco Polo, Williams, Nicola, Morrison, Hazel, Stylianou, Elena, Folegatti, Pedro, Jenkin, Daniel, Vermaak, Samantha, Rask, Linnea, Cabrera Puig, Ingrid, Powell Doherty, Rebecca, Lawrie, Alison, Moss, Paul, Hinks, Timothy, Bettinson, Henry, and McShane, Helen
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- 2024
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3. Safety and efficacy of malaria vaccine candidate R21/Matrix-M in African children: a multicentre, double-blind, randomised, phase 3 trial
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Mahamar, Almahamoudou, Sanogo, Koualy, Sidibe, Youssoufa, Diarra, Kalifa, Samassekou, Mamoudou, Attaher, Oumar, Tapily, Amadou, Diallo, Makonon, Dicko, Oumar Mohamed, Kaya, Mahamadou, Maguiraga, Seydina Oumar, Sankare, Yaya, Yalcouye, Hama, Diarra, Soumaila, Niambele, Sidi Mohamed, Thera, Ismaila, Sagara, Issaka, Sylla, Mala, Dolo, Amagana, Misidai, Nsajigwa, Simando, Sylvester, Msami, Hania, Juma, Omary, Gutapaka, Nicolaus, Paul, Rose, Mswata, Sarah, Sasamalo, Ibrahim, Johaness, Kasmir, Sultan, Mwantumu, Alexander, Annastazia, Kimaro, Isaac, Lwanga, Kauye, Mtungwe, Mwajuma, Khamis, Kassim, Rugarabam, Lighton, Kalinga, Wilmina, Mohammed, Mohammed, Kamange, Janeth, Msangi, Jubilate, Mwaijande, Batuli, Mtaka, Ivanny, Mhapa, Matilda, Mlaganile, Tarsis, Mbaga, Thabit, Yerbanga, Rakiswende Serge, Samtouma, Wendkouni, Sienou, Abdoul Aziz, Kabre, Zachari, Ouedraogo, Wendinpui Jedida Muriel, Yarbanga, G Armel Bienvenu, Zongo, Issaka, Savadogo, Hamade, Sanon, Joseph, Compaore, Judicael, Kere, Idrissa, Yoni, Ferdinand Lionel, Sanre, Tewende Martine, Ouattara, Seydou Bienvenu, Provstgaard-Morys, Samuel, Woods, Danielle, Snow, Robert W., Amek, Nyaguara, Ngetsa, Caroline J., Ochola-Oyier, Lynette Isabella, Musyoki, Jennifer, Munene, Marianne, Mumba, Noni, Adetifa, Uche Jane, Muiruri, Charles Mwangi, Mwawaka, Jimmy Shangala, Mwaganyuma, Mwatasa Hussein, Ndichu, Martha Njeri, Weya, Joseph Ochieng, Njogu, Kelvin, Grant, Jane, Webster, Jayne, Lakhkar, Anand, Ido, N. Félix André, Traore, Ousmane, Tahita, Marc Christian, Bonko, Massa dit Achille, Rouamba, Toussaint, Ouedraogo, D. Florence, Soma, Rachidatou, Millogo, Aida, Ouedraogo, Edouard, Sorgho, Faizatou, Konate, Fabé, Valea, Innocent, Datoo, Mehreen S, Dicko, Alassane, Tinto, Halidou, Ouédraogo, Jean-Bosco, Hamaluba, Mainga, Olotu, Ally, Beaumont, Emma, Ramos Lopez, Fernando, Natama, Hamtandi Magloire, Weston, Sophie, Chemba, Mwajuma, Compaore, Yves Daniel, Issiaka, Djibrilla, Salou, Diallo, Some, Athanase M, Omenda, Sharon, Lawrie, Alison, Bejon, Philip, Rao, Harish, Chandramohan, Daniel, Roberts, Rachel, Bharati, Sandesh, Stockdale, Lisa, Gairola, Sunil, Greenwood, Brian M, Ewer, Katie J, Bradley, John, Kulkarni, Prasad S, Shaligram, Umesh, and Hill, Adrian V S
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- 2024
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- View/download PDF
4. Superior antibody immunogenicity of a viral-vectored RH5 blood-stage malaria vaccine in Tanzanian infants as compared to adults
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Silk, Sarah E., Kalinga, Wilmina F., Mtaka, Ivanny M., Lilolime, Nasoro S., Mpina, Maximillian, Milando, Florence, Ahmed, Saumu, Diouf, Ababacar, Mkwepu, Fatuma, Simon, Beatus, Athumani, Thabit, Rashid, Mohammed, Mohammed, Latipha, Lweno, Omary, Ali, Ali M., Nyaulingo, Gloria, Mwalimu, Bakari, Mswata, Sarah, Mwamlima, Tunu G., Barrett, Jordan R., Wang, Lawrence T., Themistocleous, Yrene, King, Lloyd D.W., Hodgson, Susanne H., Payne, Ruth O., Nielsen, Carolyn M., Lawrie, Alison M., Nugent, Fay L., Cho, Jee-Sun, Long, Carole A., Miura, Kazutoyo, Draper, Simon J., Minassian, Angela M., and Olotu, Ally I.
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- 2023
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5. Safety and immunogenicity of a ChAdOx1 vaccine against Rift Valley fever in UK adults: an open-label, non-randomised, first-in-human phase 1 clinical trial
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Jenkin, Daniel, Wright, Daniel, Folegatti, Pedro M, Platt, Abigail, Poulton, Ian, Lawrie, Alison, Tran, Nguyen, Boyd, Amy, Turner, Cheryl, Gitonga, John N, Karanja, Henry K, Mugo, Daisy, Ewer, Katie J, Bowden, Thomas A, Gilbert, Sarah C, Charleston, Bryan, Kaleebu, Pontiano, Hill, Adrian V S, and Warimwe, George M
- Published
- 2023
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6. Efficacy and immunogenicity of R21/Matrix-M vaccine against clinical malaria after 2 years' follow-up in children in Burkina Faso: a phase 1/2b randomised controlled trial
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Datoo, Mehreen S, Natama, Hamtandi Magloire, Somé, Athanase, Bellamy, Duncan, Traoré, Ousmane, Rouamba, Toussaint, Tahita, Marc Christian, Ido, N Félix André, Yameogo, Prisca, Valia, Daniel, Millogo, Aida, Ouedraogo, Florence, Soma, Rachidatou, Sawadogo, Seydou, Sorgho, Faizatou, Derra, Karim, Rouamba, Eli, Ramos-Lopez, Fernando, Cairns, Matthew, Provstgaard-Morys, Samuel, Aboagye, Jeremy, Lawrie, Alison, Roberts, Rachel, Valéa, Innocent, Sorgho, Hermann, Williams, Nicola, Glenn, Gregory, Fries, Louis, Reimer, Jenny, Ewer, Katie J, Shaligram, Umesh, Hill, Adrian V S, and Tinto, Halidou
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- 2022
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7. First Phase 1b, single-center, age de-escalation trial of theP. falciparumblood-stage malaria vaccine candidate RH5.1/Matrix-M™: a delayed boost regimen induces high levels of functional antibodies in 5-17 month old Tanzanian infants
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Silk, Sarah E., primary, Kalinga, Wilmina F., additional, Salkeld, Jo, additional, Mtaka, Ivanny M., additional, Ahmed, Saumu, additional, Milando, Florence, additional, Diouf, Ababacar, additional, Bundi, Caroline K., additional, Balige, Neema, additional, Hassan, Omar, additional, Mkindi, Catherine G., additional, Rwezaula, Stella, additional, Athumani, Thabit, additional, Mswata, Sarah, additional, Lilolime, Nasoro S., additional, Simon, Beatus, additional, Msami, Hania, additional, Mohamed, Mohamed, additional, David, Damiano M., additional, Mohammed, Latipha, additional, Nyaulingo, Gloria, additional, Mwalimu, Bakari, additional, Juma, Omary, additional, Mwamlima, Tunu G., additional, Sasamalo, Ibrahim A., additional, Mkumbange, Rose P., additional, Kamage, Janeth J., additional, Barrett, Jordan R., additional, King, Lloyd D. W., additional, Hou, Mimi M., additional, Pulido, David, additional, Carnrot, Cecilia, additional, Lawrie, Alison M., additional, Cowan, Rachel E., additional, Nugent, Fay L., additional, Roberts, Rachel, additional, Cho, Jee-Sun, additional, Long, Carole A., additional, Nielsen, Carolyn M., additional, Miura, Kazutoyo, additional, Draper, Simon J., additional, Olotu, Ally I., additional, and Minassian, Angela M., additional
- Published
- 2024
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8. Reactogenicity and immunogenicity after a late second dose or a third dose of ChAdOx1 nCoV-19 in the UK: a substudy of two randomised controlled trials (COV001 and COV002)
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Adlou, Syed, Aley, Robert, Ali, Aabidah, Anslow, Rachel, Baker, Megan, Baker, Phillip, Barrett, Jordan R., Bates, Louise, Beadon, Kirsten, Beckley, Rebecca, Bell, Jonathan, Bellamy, Duncan, Beveridge, Amy, Bissett, Cameron, Blackwell, Luke, Bletchly, Heather, Boyd, Amy, Bridges-Webb, Alice, Brown, Charlie, Byard, Nicholas, Camara, Susana, Cifuentes Gutierrez, Liliana, Collins, Andrea M., Cooper, Rachel, Crocker, Wendy E.M., Darton, Thomas C., Davies, Hannah, Davies, Judith, Demissie, Tesfaye, Di Maso, Claudio, Dinesh, Tanya, Donnellan, Francesca R., Douglas, Alexander D., Drake-Brockman, Rachael, Duncan, Christopher J.A., Elias, Sean C., Emary, Katherine R.W., Ghulam Farooq, Mutjaba, Faust, Saul N., Felle, Sally, Ferreira, Daniela, Ferreira Da Silva, Carla, Finn, Adam, Ford, Karen J., Francis, Emma, Furze, Julie, Fuskova, Michelle, Galiza, Eva, Gibertoni Cruz, Ana, Godfrey, Leila, Goodman, Anna L., Green, Catherine, Green, Christopher A., Greenwood, Nicola, Harrison, Daisy, Hart, Thomas C., Hawkins, Sophia, Heath, Paul T., Hill, Helen, Hillson, Kushalinii, Horsington, Bryn, Hou, Mimi M., Howe, Elizabeth, Howell, Nicola, Joe, Carina, Jones, Elizabeth, Kasanyinga, Mwila, Keen, Jade, Kelly, Sarah, Kerr, David, Khan, Liaquat, Khozoee, Baktash, Kinch, Jasmin, Kinch, Patrick, Koleva, Stanislava, Kwok, Jonathan, Larkworthy, Colin W., Lawrie, Alison M., Lazarus, Rajeka, Lees, Emily A., Li, Grace, Libri, Vincenzo, Lillie, Patrick J., Linder, Aline, Long, Fei, Lopez Ramon, Raquel, Mabbett, Reece, Makinson, Rebecca, Marinou, Spyridoula, Marlow, Emma, Marshall, Julia L., Mazur, Olga, McEwan, Joanne, McGregor, Alastair C., Mokaya, Jolynne, Morey, Ella, Morshead, Gertraud, Morter, Richard, Muller, Jilly, Mweu, Philomena, Noristani, Rabiullah, Owino, Nelly, Polo Peralta Alvarez, Marco, Platt, Abigail, Pollock, Katrina M., Poulton, Ian, Provstgaard-Morys, Samuel, Pulido-Gomez, David, Rajan, Matthew, Ramos Lopez, Fernando, Ritchie, Adam, Roberts, Hannah, Rollier, Christine, Rudiansyah, Indra, Sanders, Katherine, Saunders, Jack E., Seddiqi, Samiullah, Sharpe, Hannah R., Shaw, Robert, Silva-Reyes, Laura, Singh, Nisha, Smith, David J., Smith, Catherine C., Smith, Andrew, Spencer, Alexandra J., Stuart, Arabella S.V., Sutherland, Rebecca, Szigeti, Anna, Tang, Karly, Thomas, Merin, Thomas, Tonia M., Thompson, Amber, Thomson, Emma C., Török, Estée M., Toshner, Mark, Tran, Nguyen, Trivett, Rose, Turnbull, Iain, Turner, Cheryl, Turner, David P.J., Ulaszewska, Marta, Vichos, Iason, Walker, Laura, Watson, Marion E., Whelan, Conor, White, Rachel, Williams, Sarah J., Williams, Christopher J.A., Wright, Daniel, Yao, Andy, Flaxman, Amy, Marchevsky, Natalie G, Jenkin, Daniel, Aboagye, Jeremy, Aley, Parvinder K, Angus, Brian, Belij-Rammerstorfer, Sandra, Bibi, Sagida, Bittaye, Mustapha, Cappuccini, Federica, Cicconi, Paola, Clutterbuck, Elizabeth A, Davies, Sophie, Dejnirattisai, Wanwisa, Dold, Christina, Ewer, Katie J, Folegatti, Pedro M, Fowler, Jamie, Hill, Adrian V S, Kerridge, Simon, Minassian, Angela M, Mongkolsapaya, Juthathip, Mujadidi, Yama F, Plested, Emma, Ramasamy, Maheshi N, Robinson, Hannah, Sanders, Helen, Sheehan, Emma, Smith, Holly, Snape, Matthew D, Song, Rinn, Woods, Danielle, Screaton, Gavin, Gilbert, Sarah C, Voysey, Merryn, Pollard, Andrew J, and Lambe, Teresa
- Published
- 2021
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9. Safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 in HIV infection: a single-arm substudy of a phase 2/3 clinical trial
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Watson, Marion E.E., Song, Rinn, Cicconi, Paola, Minassian, Angela M., Bibi, Sagida, Kerridge, Simon, Singh, Nisha, Green, Catherine M., Douglas, Alexander D., Lawrie, Alison M., Clutterbuck, Elizabeth A., Frater, John, Ewer, Katie J, Ogbe, Ane, Pace, Mathew, Adele, Sandra, Adland, Emily, Alagaratnam, Jasmini, Aley, Parvinder K, Ali, Mohammad, Ansari, M Azim, Bara, Anna, Bittaye, Mustapha, Broadhead, Samantha, Brown, Anthony, Brown, Helen, Cappuccini, Federica, Cooney, Enya, Dejnirattisai, Wanwisa, Dold, Christina, Fairhead, Cassandra, Fok, Henry, Folegatti, Pedro M, Fowler, Jamie, Gibbs, Charlotte, Goodman, Anna L, Jenkin, Daniel, Jones, Mathew, Makinson, Rebecca, Marchevsky, Natalie G, Mujadidi, Yama F, Nguyen, Hanna, Parolini, Lucia, Petersen, Claire, Plested, Emma, Pollock, Katrina M, Ramasamy, Maheshi N, Rhead, Sarah, Robinson, Hannah, Robinson, Nicola, Rongkard, Patpong, Ryan, Fiona, Serrano, Sonia, Tipoe, Timothy, Voysey, Merryn, Waters, Anele, Zacharopoulou, Panagiota, Barnes, Eleanor, Dunachie, Susanna, Goulder, Philip, Klenerman, Paul, Screaton, Gavin R, Winston, Alan, Hill, Adrian V S, Gilbert, Sarah C, Pollard, Andrew J, Fidler, Sarah, Fox, Julie, and Lambe, Teresa
- Published
- 2021
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10. Reduced blood-stage malaria growth and immune correlates in humans following RH5 vaccination
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Minassian, Angela M., Silk, Sarah E., Barrett, Jordan R., Nielsen, Carolyn M., Miura, Kazutoyo, Diouf, Ababacar, Loos, Carolin, Fallon, Jonathan K., Michell, Ashlin R., White, Michael T., Edwards, Nick J., Poulton, Ian D., Mitton, Celia H., Payne, Ruth O., Marks, Michael, Maxwell-Scott, Hector, Querol-Rubiera, Antonio, Bisnauthsing, Karen, Batra, Rahul, Ogrina, Tatiana, Brendish, Nathan J., Themistocleous, Yrene, Rawlinson, Thomas A., Ellis, Katherine J., Quinkert, Doris, Baker, Megan, Lopez Ramon, Raquel, Ramos Lopez, Fernando, Barfod, Lea, Folegatti, Pedro M., Silman, Daniel, Datoo, Mehreen, Taylor, Iona J., Jin, Jing, Pulido, David, Douglas, Alexander D., de Jongh, Willem A., Smith, Robert, Berrie, Eleanor, Noe, Amy R., Diggs, Carter L., Soisson, Lorraine A., Ashfield, Rebecca, Faust, Saul N., Goodman, Anna L., Lawrie, Alison M., Nugent, Fay L., Alter, Galit, Long, Carole A., and Draper, Simon J.
- Published
- 2021
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11. Safety and immunogenicity of a candidate Middle East respiratory syndrome coronavirus viral-vectored vaccine: a dose-escalation, open-label, non-randomised, uncontrolled, phase 1 trial
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Folegatti, Pedro M, Bittaye, Mustapha, Flaxman, Amy, Lopez, Fernando Ramos, Bellamy, Duncan, Kupke, Alexandra, Mair, Catherine, Makinson, Rebecca, Sheridan, Jonathan, Rohde, Cornelius, Halwe, Sandro, Jeong, Yuji, Park, Young-Shin, Kim, Jae-Ouk, Song, Manki, Boyd, Amy, Tran, Nguyen, Silman, Daniel, Poulton, Ian, Datoo, Mehreen, Marshall, Julia, Themistocleous, Yrene, Lawrie, Alison, Roberts, Rachel, Berrie, Eleanor, Becker, Stephan, Lambe, Teresa, Hill, Adrian, Ewer, Katie, and Gilbert, Sarah
- Published
- 2020
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12. A single dose of ChAdOx1 Chik vaccine induces neutralizing antibodies against four chikungunya virus lineages in a phase 1 clinical trial
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Folegatti, Pedro M., Harrison, Kate, Preciado-Llanes, Lorena, Lopez, Fernando Ramos, Bittaye, Mustapha, Kim, Young Chan, Flaxman, Amy, Bellamy, Duncan, Makinson, Rebecca, Sheridan, Jonathan, Azar, Sasha R., Campos, Rafael Kroon, Tilley, Mark, Tran, Nguyen, Jenkin, Daniel, Poulton, Ian, Lawrie, Alison, Roberts, Rachel, Berrie, Eleanor, Rossi, Shannan L., Hill, Adrian, Ewer, Katie J., and Reyes-Sandoval, Arturo
- Published
- 2021
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13. Safety and immunogenicity of varied doses of R21/Matrix-M™ vaccine at three years follow-up: A phase 1b age de-escalation, dose-escalation trial in adults, children, and infants in Kilifi-Kenya
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Sang, Samuel, primary, Datoo, Mehreen S., additional, Otieno, Edward, additional, Muiruri, Charles, additional, Bellamy, Duncan, additional, Gathuri, Emmaloise, additional, Ngoto, Omar, additional, Musembi, Janet, additional, Provstgaard-Morys, Sam, additional, Stockdale, Lisa, additional, Aboagye, Jeremy, additional, Woods, Daniel, additional, Lawrie, Alison, additional, Roberts, Racheal, additional, Keter, Kelvias, additional, Kimani, Domtila, additional, Ndungu, Francis, additional, Kapulu, Melissa, additional, Njau, Irene, additional, Orindi, Benedict, additional, Ewer, Katie J., additional, Hill, Adrian V.S., additional, Bejon, Philip, additional, and Hamaluba, Mainga, additional
- Published
- 2023
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14. Vaccination with Plasmodium vivax Duffy-binding protein inhibits parasite growth during controlled human malaria infection
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Hou, Mimi M., primary, Barrett, Jordan R., additional, Themistocleous, Yrene, additional, Rawlinson, Thomas A., additional, Diouf, Ababacar, additional, Martinez, Francisco J., additional, Nielsen, Carolyn M., additional, Lias, Amelia M., additional, King, Lloyd D. W., additional, Edwards, Nick J., additional, Greenwood, Nicola M., additional, Kingham, Lucy, additional, Poulton, Ian D., additional, Khozoee, Baktash, additional, Goh, Cyndi, additional, Hodgson, Susanne H., additional, Mac Lochlainn, Dylan J., additional, Salkeld, Jo, additional, Guillotte-Blisnick, Micheline, additional, Huon, Christèle, additional, Mohring, Franziska, additional, Reimer, Jenny M., additional, Chauhan, Virander S., additional, Mukherjee, Paushali, additional, Biswas, Sumi, additional, Taylor, Iona J., additional, Lawrie, Alison M., additional, Cho, Jee-Sun, additional, Nugent, Fay L., additional, Long, Carole A., additional, Moon, Robert W., additional, Miura, Kazutoyo, additional, Silk, Sarah E., additional, Chitnis, Chetan E., additional, Minassian, Angela M., additional, and Draper, Simon J., additional
- Published
- 2023
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15. Safety and immunogenicity of heterologous prime-boost immunization with viral-vectored malaria vaccines adjuvanted with Matrix-M™
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Venkatraman, Navin, Anagnostou, Nicholas, Bliss, Carly, Bowyer, Georgina, Wright, Danny, Lövgren-Bengtsson, Karin, Roberts, Rachel, Poulton, Ian, Lawrie, Alison, Ewer, Katie, and V. S. Hill, Adrian
- Published
- 2017
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16. Superior antibody immunogenicity of a RH5 blood-stage malaria vaccine in Tanzanian infants as compared to adults
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Silk, Sarah E, primary, Kalinga, Wilmina F, additional, Mtaka, Ivanny M, additional, Lilolime, Nasoro S, additional, Mpina, Maximillian, additional, Milando, Florence, additional, Ahmed, Saumu, additional, Diouf, Ababacar, additional, Mkwepu, Fatuma, additional, Simon, Beatus, additional, Athumani, Thabit, additional, Rashid, Mohammed, additional, Mohammed, Latipha, additional, Lweno, Omary, additional, Ali, Ali M, additional, Nyaulingo, Gloria, additional, Mwalimu, Bakari, additional, Mswata, Sarah, additional, Mwamlima, Tunu G, additional, Barrett, Jordan R, additional, Wang, Lawrence T, additional, Themistocleous, Yrene, additional, King, Lloyd D W, additional, Hodgson, Susanne H, additional, Payne, Ruth O, additional, Nielsen, Carolyn M, additional, Lawrie, Alison M, additional, Nugent, Fay L, additional, Cho, Jee-Sun, additional, Long, Carole A, additional, Miura, Kazutoyo, additional, Draper, Simon J, additional, Minassian, Angela M, additional, and Olotu, Ally I, additional
- Published
- 2023
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17. A first-in-human phase 1 trial to evaluate the safety and immunogenicity of the candidate tuberculosis vaccine MVA85A-IMX313, administered to BCG-vaccinated adults
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Minhinnick, Alice, Satti, Iman, Harris, Stephanie, Wilkie, Morven, Sheehan, Sharon, Stockdale, Lisa, Thomas, Zita-Rose Manjaly, Lopez-Ramon, Raquel, Poulton, Ian, Lawrie, Alison, Vermaak, Samantha, Le Vert, Alexandre, Del Campo, Judith, Hill, Fergal, Moss, Paul, and McShane, Helen
- Published
- 2016
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18. Safety and High Level Efficacy of the Combination Malaria Vaccine Regimen of RTS,S/AS01 B With Chimpanzee Adenovirus 63 and Modified Vaccinia Ankara Vectored Vaccines Expressing ME-TRAP
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Rampling, Tommy, Ewer, Katie J., Bowyer, Georgina, Bliss, Carly M., Edwards, Nick J., Wright, Danny, Payne, Ruth O., Venkatraman, Navin, de Barra, Eoghan, Snudden, Claudia M., Poulton, Ian D., de Graaf, Hans, Sukhtankar, Priya, Roberts, Rachel, Ivinson, Karen, Weltzin, Rich, Rajkumar, Bebi-Yassin, Wille-Reece, Ulrike, Lee, Cynthia K., Ockenhouse, Christian F., Sinden, Robert E., Gerry, Stephen, Lawrie, Alison M., Vekemans, Johan, Morelle, Danielle, Lievens, Marc, Ballou, Ripley W., Cooke, Graham S., Faust, Saul N., Gilbert, Sarah, and Hill, Adrian V. S.
- Published
- 2016
19. Demonstration of the Blood-Stage Plasmodium falciparum Controlled Human Malaria Infection Model to Assess Efficacy of the P. falciparum Apical Membrane Antigen 1 Vaccine, FMP2.1/AS01
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Payne, Ruth O., Milne, Kathryn H., Elias, Sean C., Edwards, Nick J., Douglas, Alexander D., Brown, Rebecca E., Silk, Sarah E., Biswas, Sumi, Miura, Kazutoyo, Roberts, Rachel, Rampling, Thomas W., Venkatraman, Navin, Hodgson, Susanne H., Labbé, Geneviève M., Halstead, Fenella D., Poulton, Ian D., Nugent, Fay L., de Graaf, Hans, Sukhtankar, Priya, Williams, Nicola C., Ockenhouse, Christian F., Kathcart, April K., Qabar, Aziz N., Waters, Norman C., Soisson, Lorraine A., Birkett, Ashley J., Cooke, Graham S., Faust, Saul N., Woods, Colleen, Ivinson, Karen, McCarthy, James S., Diggs, Carter L., Vekemans, Johan, Long, Carole A., Hill, Adrian V. S., Lawrie, Alison M., Dutta, Sheetij, and Draper, Simon J.
- Published
- 2016
20. Temporal and spatial Ca'2'+ signals in pancreatic acinar cells
- Author
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Lawrie, Alison M.
- Subjects
572 ,Lacrimal acinar cells ,Free calcium - Published
- 1994
21. Synthesis and characterisation of human glycoproteins in insect cells
- Author
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Lawrie, Alison M.
- Subjects
572.8 ,Genetics - Published
- 1993
22. Safety and efficacy of malaria vaccine candidate R21/Matrix-M in African children: a multicentre, double-blind, randomised, phase 3 trial
- Author
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Datoo, Mehreen S, Dicko, Alassane, Tinto, Halidou, Ouédraogo, Jean-Bosco, Hamaluba, Mainga, Olotu, Ally, Beaumont, Emma, Ramos Lopez, Fernando, Natama, Hamtandi Magloire, Weston, Sophie, Chemba, Mwajuma, Compaore, Yves Daniel, Issiaka, Djibrilla, Salou, Diallo, Some, Athanase M, Omenda, Sharon, Lawrie, Alison, Bejon, Philip, Rao, Harish, Chandramohan, Daniel, Roberts, Rachel, Bharati, Sandesh, Stockdale, Lisa, Gairola, Sunil, Greenwood, Brian M, Ewer, Katie J, Bradley, John, Kulkarni, Prasad S, Shaligram, Umesh, Hill, Adrian V S, Mahamar, Almahamoudou, Sanogo, Koualy, Sidibe, Youssoufa, Diarra, Kalifa, Samassekou, Mamoudou, Attaher, Oumar, Tapily, Amadou, Diallo, Makonon, Dicko, Oumar Mohamed, Kaya, Mahamadou, Maguiraga, Seydina Oumar, Sankare, Yaya, Yalcouye, Hama, Diarra, Soumaila, Niambele, Sidi Mohamed, Thera, Ismaila, Sagara, Issaka, Sylla, Mala, Dolo, Amagana, Misidai, Nsajigwa, Simando, Sylvester, Msami, Hania, Juma, Omary, Gutapaka, Nicolaus, Paul, Rose, Mswata, Sarah, Sasamalo, Ibrahim, Johaness, Kasmir, Sultan, Mwantumu, Alexander, Annastazia, Kimaro, Isaac, Lwanga, Kauye, Mtungwe, Mwajuma, Khamis, Kassim, Rugarabam, Lighton, Kalinga, Wilmina, Mohammed, Mohammed, Kamange, Janeth, Msangi, Jubilate, Mwaijande, Batuli, Mtaka, Ivanny, Mhapa, Matilda, Mlaganile, Tarsis, Mbaga, Thabit, Yerbanga, Rakiswende Serge, Samtouma, Wendkouni, Sienou, Abdoul Aziz, Kabre, Zachari, Ouedraogo, Wendinpui Jedida Muriel, Yarbanga, G Armel Bienvenu, Zongo, Issaka, Savadogo, Hamade, Sanon, Joseph, Compaore, Judicael, Kere, Idrissa, Yoni, Ferdinand Lionel, Sanre, Tewende Martine, Ouattara, Seydou Bienvenu, Provstgaard-Morys, Samuel, Woods, Danielle, Snow, Robert W., Amek, Nyaguara, Ngetsa, Caroline J., Ochola-Oyier, Lynette Isabella, Musyoki, Jennifer, Munene, Marianne, Mumba, Noni, Adetifa, Uche Jane, Muiruri, Charles Mwangi, Mwawaka, Jimmy Shangala, Mwaganyuma, Mwatasa Hussein, Ndichu, Martha Njeri, Weya, Joseph Ochieng, Njogu, Kelvin, Grant, Jane, Webster, Jayne, Lakhkar, Anand, Ido, N. Félix André, Traore, Ousmane, Tahita, Marc Christian, Bonko, Massa dit Achille, Rouamba, Toussaint, Ouedraogo, D. Florence, Soma, Rachidatou, Millogo, Aida, Ouedraogo, Edouard, Sorgho, Faizatou, Konate, Fabé, and Valea, Innocent
- Abstract
Recently, we found that a new malaria vaccine, R21/Matrix-M, had over 75% efficacy against clinical malaria with seasonal administration in a phase 2b trial in Burkina Faso. Here, we report on safety and efficacy of the vaccine in a phase 3 trial enrolling over 4800 children across four countries followed for up to 18 months at seasonal sites and 12 months at standard sites.
- Published
- 2024
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23. A Phase 1b Clinical Trial to Determine the Safety, Tolerability and Immunogenicity of the Candidate Mycobacterium Avium Complex Subspecies Vaccines ChAdOx2 HAV and MVA HAV in Patients with Active Crohn's Disease
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Sanderson, Jeremy, primary, Aboagye, Jeremy, additional, Makinson, Rebecca, additional, Rapi, Katerina, additional, Provstgaard-Morys, Samuel, additional, Stockdale, Lisa, additional, Lawrie, Alison M., additional, Lanigan, Isabelle, additional, Halim, Nishat, additional, Douiri, Abdel, additional, Greenlay, Emily, additional, Malek, Rayka, additional, Gray, Emma, additional, West, Lindsey, additional, El Oulidi, Fatima, additional, Cross, Paul Ian, additional, Stallibrass, Michael, additional, Gilbert, Sarah C., additional, Hill, Adrian V. S., additional, and Ewer, Katie J., additional
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- 2023
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24. A Phase III Randomised Controlled Trial Evaluating the Malaria Vaccine Candidate R21/Matrix-M™ in African Children
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Datoo, Mehreen M., primary, Dicko, Alassane, additional, Tinto, Halidou, additional, Ouédraogo, Jean-Bosco, additional, Hamaluba, Mainga, additional, Olotu, Ally, additional, Beaumont, Emma, additional, Ramos-Lopez, Fernando, additional, Magloire Natama, Hamtandi, additional, Weston, Sophie, additional, Chemba, Mwajuma, additional, Compaore, Yves D., additional, Issiaka, Djibrilla, additional, Salou, Diallo, additional, Omenda, Sharon, additional, Lawrie, Alison, additional, Bejon, Philip, additional, and Hill, Adrian V. S., additional
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- 2023
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25. Evaluation of the Efficacy of ChAd63-MVA Vectored Vaccines Expressing Circumsporozoite Protein and ME-TRAP Against Controlled Human Malaria Infection in Malaria-Naive Individuals
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Hodgson, Susanne H., Ewer, Katie J., Bliss, Carly M., Edwards, Nick J., Rampling, Thomas, Anagnostou, Nicholas A., de Barra, Eoghan, Havelock, Tom, Bowyer, Georgina, Poulton, Ian D., de Cassan, Simone, Longley, Rhea, Illingworth, Joseph J., Douglas, Alexander D., Mange, Pooja B., Collins, Katharine A., Roberts, Rachel, Gerry, Stephen, Berrie, Eleanor, Moyle, Sarah, Colloca, Stefano, Cortese, Riccardo, Sinden, Robert E., Gilbert, Sarah C., Bejon, Philip, Lawrie, Alison M., Nicosia, Alfredo, Faust, Saul N., and Hill, Adrian V. S.
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- 2015
26. Safety and efficacy of novel malaria vaccine regimens of RTS,S/AS01B alone, or with concomitant ChAd63-MVA-vectored vaccines expressing ME-TRAP
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Rampling, Tommy, Ewer, Katie J., Bowyer, Georgina, Edwards, Nick J., Wright, Danny, Sridhar, Saranya, Payne, Ruth, Powlson, Jonathan, Bliss, Carly, Venkatraman, Navin, Poulton, Ian D., de Graaf, Hans, Gbesemete, Diane, Grobbelaar, Amy, Davies, Huw, Roberts, Rachel, Angus, Brian, Ivinson, Karen, Weltzin, Rich, Rajkumar, Bebi-Yassin, Wille-Reece, Ulrike, Lee, Cynthia, Ockenhouse, Chris, Sinden, Robert E., Gerry, Stephen C., Lawrie, Alison M., Vekemans, Johan, Morelle, Danielle, Lievens, Marc, Ballou, Ripley W., Lewis, David J. M., Cooke, Graham S., Faust, Saul N., Gilbert, Sarah, and Hill, Adrian V. S
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- 2018
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27. Production, quality control, stability, and potency of cGMP-produced Plasmodium falciparum RH5.1 protein vaccine expressed in Drosophila S2 cells
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Jin, Jing, Tarrant, Richard D., Bolam, Emma J., Angell-Manning, Philip, Soegaard, Max, Pattinson, David J., Dulal, Pawan, Silk, Sarah E., Marshall, Jennifer M., Dabbs, Rebecca A., Nugent, Fay L., Barrett, Jordan R., Hjerrild, Kathryn A., Poulsen, Lars, Jørgensen, Thomas, Brenner, Tanja, Baleanu, Ioana N., Parracho, Helena M., Tahiri-Alaoui, Abdessamad, Whale, Gary, Moyle, Sarah, Payne, Ruth O., Minassian, Angela M., Higgins, Matthew K., Detmers, Frank J., Lawrie, Alison M., Douglas, Alexander D., Smith, Robert, de Jongh, Willem A., Berrie, Eleanor, Ashfield, Rebecca, and Draper, Simon J.
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- 2018
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28. Repeat controlled human malaria infection of healthy UK adults with blood-stage Plasmodium falciparum: Safety and parasite growth dynamics
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Salkeld, Jo, primary, Themistocleous, Yrene, additional, Barrett, Jordan R., additional, Mitton, Celia H., additional, Rawlinson, Thomas A., additional, Payne, Ruth O., additional, Hou, Mimi M., additional, Khozoee, Baktash, additional, Edwards, Nick J., additional, Nielsen, Carolyn M., additional, Sandoval, Diana Muñoz, additional, Bach, Florian A., additional, Nahrendorf, Wiebke, additional, Ramon, Raquel Lopez, additional, Baker, Megan, additional, Ramos-Lopez, Fernando, additional, Folegatti, Pedro M., additional, Quinkert, Doris, additional, Ellis, Katherine J., additional, Poulton, Ian D., additional, Lawrie, Alison M., additional, Cho, Jee-Sun, additional, Nugent, Fay L., additional, Spence, Philip J., additional, Silk, Sarah E., additional, Draper, Simon J., additional, and Minassian, Angela M., additional
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- 2022
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29. Repeat controlled human malaria infection of healthy UK adults with blood-stagePlasmodium falciparum: safety and parasite growth dynamics
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Salkeld, Jo, primary, Themistocleous, Yrene, additional, Barrett, Jordan R., additional, Mitton, Celia H., additional, Rawlinson, Thomas A., additional, Payne, Ruth O., additional, Hou, Mimi M., additional, Khozoee, Baktash, additional, Edwards, Nick J., additional, Nielsen, Carolyn M., additional, Sandoval, Diana Muñoz, additional, Bach, Florian A., additional, Nahrendorf, Wiebke, additional, Ramon, Raquel Lopez, additional, Baker, Megan, additional, Ramos-Lopez, Fernando, additional, Folegatti, Pedro M., additional, Quinkert, Doris, additional, Ellis, Katherine J., additional, Poulton, Ian D., additional, Lawrie, Alison M., additional, Cho, Jee-Sun, additional, Nugent, Fay L., additional, Spence, Philip J., additional, Silk, Sarah E., additional, Draper, Simon J., additional, and Minassian, Angela M., additional
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- 2022
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30. Alternate aerosol and systemic immunisation with a recombinant viral vector for tuberculosis, MVA85A: A phase I randomised controlled trial
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Manjaly Thomas, Zita-Rose, Satti, Iman, Marshall, Julia L., Harris, Stephanie A., Lopez Ramon, Raquel, Hamidi, Ali, Minhinnick, Alice, Riste, Michael, Stockdale, Lisa, Lawrie, Alison M., Vermaak, Samantha, Wilkie, Morven, Bettinson, Henry, and McShane, Helen
- Subjects
Clinical trials -- Analysis ,Tuberculosis vaccines -- Usage ,Tuberculosis -- Risk factors -- Prevention ,Vaccines ,Antigens ,T cells ,Vaccinia ,Bronchoscopy ,Antibodies ,Immune response ,Immunization ,Pathogenic microorganisms ,Immunotherapy ,Vaccination ,Biological sciences - Abstract
Background There is an urgent need for an effective tuberculosis (TB) vaccine. Heterologous prime-boost regimens induce potent cellular immunity. MVA85A is a candidate TB vaccine. This phase I clinical trial was designed to evaluate whether alternating aerosol and intradermal vaccination routes would boost cellular immunity to the Mycobacterium tuberculosis antigen 85A (Ag85A). Methods and findings Between December 2013 and January 2016, 36 bacille Calmette-Guérin-vaccinated, healthy UK adults were randomised equally between 3 groups to receive 2 MVA85A vaccinations 1 month apart using either heterologous (Group 1, aerosol-intradermal; Group 2, intradermal-aerosol) or homologous (Group 3, intradermal-intradermal) immunisation. Bronchoscopy and bronchoalveolar lavage (BAL) were performed 7 days post-vaccination. Adverse events (AEs) and peripheral blood were collected for 6 months post-vaccination. The laboratory and bronchoscopy teams were blinded to treatment allocation. One participant was withdrawn and was replaced. Participants were aged 21-42 years, and 28/37 were female. In a per protocol analysis, aerosol delivery of MVA85A as a priming immunisation was well tolerated and highly immunogenic. Most AEs were mild local injection site reactions following intradermal vaccination. Transient systemic AEs occurred following vaccination by both routes and were most frequently mild. All respiratory AEs following primary aerosol MVA85A (Group 1) were mild. Boosting an intradermal MVA85A prime with an aerosolised MVA85A boost 1 month later (Group 2) resulted in transient moderate/severe respiratory and systemic AEs. There were no serious adverse events and no bronchoscopy-related complications. Only the intradermal-aerosol vaccination regimen (Group 2) resulted in modest, significant boosting of the cell-mediated immune response to Ag85A (p = 0.027; 95% CI: 28 to 630 spot forming cells per 1 x 10.sup.6 peripheral blood mononuclear cells). All 3 regimens induced systemic cellular immune responses to the modified vaccinia virus Ankara (MVA) vector. Serum antibodies to Ag85A and MVA were only induced after intradermal vaccination. Aerosolised MVA85A induced significantly higher levels of Ag85A lung mucosal CD4+ and CD8+ T cell cytokines compared to intradermal vaccination. Boosting with aerosol-inhaled MVA85A enhanced the intradermal primed responses in Group 2. The magnitude of BAL MVA-specific CD4+ T cell responses was lower than the Ag85A-specific responses. A limitation of the study is that while the intradermal-aerosol regimen induced the most potent cellular Ag85A immune responses, we did not boost the last 3 participants in this group because of the AE profile. Timing of bronchoscopies aimed to capture peak mucosal response; however, peak responses may have occurred outside of this time frame. Conclusions To our knowledge, this is the first human randomised clinical trial to explore heterologous prime-boost regimes using aerosol and systemic routes of administration of a virally vectored vaccine. In this trial, the aerosol prime-intradermal boost regime was well tolerated, but intradermal prime-aerosol boost resulted in transient but significant respiratory AEs. Aerosol vaccination induced potent cellular Ag85A-specific mucosal and systemic immune responses. Whilst the implications of inducing potent mucosal and systemic immunity for protection are unclear, these findings are of relevance for the development of aerosolised vaccines for TB and other respiratory and mucosal pathogens. Trial registration ClinicalTrials.gov NCT01954563., Author(s): Zita-Rose Manjaly Thomas 1, Iman Satti 1, Julia L. Marshall 1, Stephanie A. Harris 1, Raquel Lopez Ramon 1, Ali Hamidi 1, Alice Minhinnick 1, Michael Riste 1, Lisa [...]
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- 2019
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31. Clinical Assessment of a Recombinant Simian Adenovirus ChAd63: A Potent New Vaccine Vector
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O'Hara, Geraldine A., Duncan, Christopher J. A., Ewer, Katie J., Collins, Katharine A., Elias, Sean C., Halstead, Fenella D., Goodman, Anna L., Edwards, Nick J., Reyes-Sandoval, Arturo, Bird, Prudence, Rowland, Rosalind, Sheehy, Susanne H., Poulton, Ian D., Hutchings, Claire, Todryk, Stephen, Andrews, Laura, Folgori, Antonella, Berrie, Eleanor, Moyle, Sarah, Nicosia, Alfredo, Colloca, Stefano, Cortese, Riccardo, Siani, Loredana, Lawrie, Alison M., Gilbert, Sarah C., and Hill, Adrian V. S.
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- 2012
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32. A review of the tolerability of the candidate TB vaccine, MVA85A compared with BCG and Yellow Fever vaccines, and correlation between MVA85A vaccine reactogenicity and cellular immunogenicity
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Rowland, Rosalind, Brittain, Nathaniel, Poulton, Ian D, Minassian, Angela M, Sander, Clare, Porter, David W, Williams, Nicola, Satti, Iman, Pathan, Ansar A, Lawrie, Alison M, and McShane, Helen
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- 2012
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33. Impact of a blood-stage vaccine on Plasmodium vivax malaria
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Hou, Mimi M., primary, Barrett, Jordan R., additional, Themistocleous, Yrene, additional, Rawlinson, Thomas A., additional, Diouf, Ababacar, additional, Martinez, Francisco J., additional, Nielsen, Carolyn M., additional, Lias, Amelia M., additional, King, Lloyd D. W., additional, Edwards, Nick J., additional, Greenwood, Nicola M., additional, Kingham, Lucy, additional, Poulton, Ian D., additional, Khozoee, Baktash, additional, Goh, Cyndi, additional, Mac Lochlainn, Dylan J., additional, Salkeld, Jo, additional, Guilotte-Blisnick, Micheline, additional, Huon, Christèle, additional, Mohring, Franziska, additional, Reimer, Jenny M., additional, Chauhan, Virander S., additional, Mukherjee, Paushali, additional, Biswas, Sumi, additional, Taylor, Iona J., additional, Lawrie, Alison M., additional, Cho, Jee-Sun, additional, Nugent, Fay L., additional, Long, Carole A., additional, Moon, Robert W., additional, Miura, Kazutoyo, additional, Silk, Sarah E., additional, Chitnis, Chetan E., additional, Minassian, Angela M., additional, and Draper, Simon J., additional
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- 2022
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34. Dose-Finding Study of the Novel Tuberculosis Vaccine, MVA85A, in Healthy BCG-Vaccinated Infants
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Scriba, Thomas J., Tameris, Michèle, Mansoor, Nazma, Smit, Erica, van der Merwe, Linda, Mauff, Katya, Hughes, E.Jane, Moyo, Sizulu, Brittain, Nathaniel, Lawrie, Alison, Mulenga, Humphrey, de Kock, Marwou, Gelderbloem, Sebastian, Veldsman, Ashley, Hatherill, Mark, Geldenhuys, Hendrik, Hill, Adrian V.S., Hussey, Gregory D., Mahomed, Hassan, Hanekom, Willem A., and McShane, Helen
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- 2011
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35. Controlled human malaria infection with a clone of Plasmodium vivax with high-quality genome assembly
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Minassian, Angela M., primary, Themistocleous, Yrene, additional, Silk, Sarah E., additional, Barrett, Jordan R., additional, Kemp, Alison, additional, Quinkert, Doris, additional, Nielsen, Carolyn M., additional, Edwards, Nick J., additional, Rawlinson, Thomas A., additional, Ramos Lopez, Fernando, additional, Roobsoong, Wanlapa, additional, Ellis, Katherine J.D., additional, Cho, Jee-Sun, additional, Aunin, Eerik, additional, Otto, Thomas D., additional, Reid, Adam J., additional, Bach, Florian A., additional, Labbé, Geneviève M.C., additional, Poulton, Ian D., additional, Marini, Arianna, additional, Zaric, Marija, additional, Mulatier, Margaux, additional, Lopez Ramon, Raquel, additional, Baker, Megan, additional, Mitton, Celia H., additional, Sousa, Jason C., additional, Rachaphaew, Nattawan, additional, Kumpitak, Chalermpon, additional, Maneechai, Nongnuj, additional, Suansomjit, Chayanut, additional, Piteekan, Tianrat, additional, Hou, Mimi M., additional, Khozoee, Baktash, additional, McHugh, Kirsty, additional, Roberts, David J., additional, Lawrie, Alison M., additional, Blagborough, Andrew M., additional, Nugent, Fay L., additional, Taylor, Iona J., additional, Johnson, Kimberly J., additional, Spence, Philip J., additional, Sattabongkot, Jetsumon, additional, Biswas, Sumi, additional, Rayner, Julian C., additional, and Draper, Simon J., additional
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- 2021
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36. A Monovalent Chimpanzee Adenovirus Ebola Vaccine Boosted with MVA
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Ewer, Katie, Rampling, Tommy, Venkatraman, Navin, Bowyer, Georgina, Wright, Danny, Lambe, Teresa, Imoukhuede, Egeruan B., Payne, Ruth, Fehling, Sarah Katharina, Strecker, Thomas, Biedenkopf, Nadine, Krähling, Verena, Tully, Claire M., Edwards, Nick J., Bentley, Emma M., Samuel, Dhanraj, Labbé, Geneviève, Jin, Jing, Gibani, Malick, Minhinnick, Alice, Wilkie, Morven, Poulton, Ian, Lella, Natalie, Roberts, Rachel, Hartnell, Felicity, Bliss, Carly, Sierra-Davidson, Kailan, Powlson, Jonathan, Berrie, Eleanor, Tedder, Richard, Roman, Francois, De Ryck, Iris, Nicosia, Alfredo, Sullivan, Nancy J., Stanley, Daphne A., Mbaya, Olivier T., Ledgerwood, Julie E., Schwartz, Richard M., Siani, Loredana, Colloca, Stefano, Folgori, Antonella, Di Marco, Stefania, Cortese, Riccardo, Wright, Edward, Becker, Stephan, Graham, Barney S., Koup, Richard A., Levine, Myron M., Volkmann, Ariane, Chaplin, Paul, Pollard, Andrew J., Draper, Simon J., Ballou, Ripley W., Lawrie, Alison, Gilbert, Sarah C., and Hill, Adrian V.S.
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- 2016
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37. A three-antigen Plasmodium falciparum DNA prime—Adenovirus boost malaria vaccine regimen is superior to a two-antigen regimen and protects against controlled human malaria infection in healthy malaria-naïve adults
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Sklar, Marvin J., primary, Maiolatesi, Santina, additional, Patterson, Noelle, additional, Sedegah, Martha, additional, Limbach, Keith, additional, Teneza-Mora, Nimfa, additional, Chuang, Ilin, additional, Hollis-Perry, K. Monique, additional, Banania, Jo Glenna, additional, Guzman, Ivelese, additional, Ganeshan, Harini, additional, Reyes, Sharina, additional, Hollingdale, Michael R., additional, Wong, Mimi, additional, Lindstrom, Ashley, additional, Reyes, Anatalio, additional, Alcorta, Yolanda, additional, Garver, Lindsey, additional, Bankard, Kelli, additional, Belmonte, Arnel, additional, Belmonte, Maria, additional, Huang, Jun, additional, Gowda, Kalpana, additional, Inoue, Sandra, additional, Velasco, Rachel, additional, Bergmann-Leitner, Elke, additional, Hutter, Jack, additional, Lee, Tida, additional, Adams, Nehkonti, additional, Chaudhury, Sidhartha, additional, Hunt, Devin, additional, Tamminga, Cindy, additional, Berrie, Eleanor, additional, Bellamy, Duncan, additional, Bittaye, Mustapha, additional, Ewer, Katie, additional, Diggs, Carter, additional, Soisson, Lorraine A., additional, Lawrie, Alison, additional, Hill, Adrian, additional, Richie, Thomas L., additional, Villasante, Eileen, additional, Epstein, Judith E., additional, and Duplessis, Christopher A., additional
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- 2021
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38. Reactogenicity and immunogenicity after a late second dose or a third dose of ChAdOx1 nCoV-19 in the UK: a substudy of two randomised controlled trials (COV001 and COV002)
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Flaxman, Amy, primary, Marchevsky, Natalie G, additional, Jenkin, Daniel, additional, Aboagye, Jeremy, additional, Aley, Parvinder K, additional, Angus, Brian, additional, Belij-Rammerstorfer, Sandra, additional, Bibi, Sagida, additional, Bittaye, Mustapha, additional, Cappuccini, Federica, additional, Cicconi, Paola, additional, Clutterbuck, Elizabeth A, additional, Davies, Sophie, additional, Dejnirattisai, Wanwisa, additional, Dold, Christina, additional, Ewer, Katie J, additional, Folegatti, Pedro M, additional, Fowler, Jamie, additional, Hill, Adrian V S, additional, Kerridge, Simon, additional, Minassian, Angela M, additional, Mongkolsapaya, Juthathip, additional, Mujadidi, Yama F, additional, Plested, Emma, additional, Ramasamy, Maheshi N, additional, Robinson, Hannah, additional, Sanders, Helen, additional, Sheehan, Emma, additional, Smith, Holly, additional, Snape, Matthew D, additional, Song, Rinn, additional, Woods, Danielle, additional, Screaton, Gavin, additional, Gilbert, Sarah C, additional, Voysey, Merryn, additional, Pollard, Andrew J, additional, Lambe, Teresa, additional, Adlou, Syed, additional, Aley, Robert, additional, Ali, Aabidah, additional, Anslow, Rachel, additional, Baker, Megan, additional, Baker, Phillip, additional, Barrett, Jordan R., additional, Bates, Louise, additional, Beadon, Kirsten, additional, Beckley, Rebecca, additional, Bell, Jonathan, additional, Bellamy, Duncan, additional, Beveridge, Amy, additional, Bissett, Cameron, additional, Blackwell, Luke, additional, Bletchly, Heather, additional, Boyd, Amy, additional, Bridges-Webb, Alice, additional, Brown, Charlie, additional, Byard, Nicholas, additional, Camara, Susana, additional, Cifuentes Gutierrez, Liliana, additional, Collins, Andrea M., additional, Cooper, Rachel, additional, Crocker, Wendy E.M., additional, Darton, Thomas C., additional, Davies, Hannah, additional, Davies, Judith, additional, Demissie, Tesfaye, additional, Di Maso, Claudio, additional, Dinesh, Tanya, additional, Donnellan, Francesca R., additional, Douglas, Alexander D., additional, Drake-Brockman, Rachael, additional, Duncan, Christopher J.A., additional, Elias, Sean C., additional, Emary, Katherine R.W., additional, Ghulam Farooq, Mutjaba, additional, Faust, Saul N., additional, Felle, Sally, additional, Ferreira, Daniela, additional, Ferreira Da Silva, Carla, additional, Finn, Adam, additional, Ford, Karen J., additional, Francis, Emma, additional, Furze, Julie, additional, Fuskova, Michelle, additional, Galiza, Eva, additional, Gibertoni Cruz, Ana, additional, Godfrey, Leila, additional, Goodman, Anna L., additional, Green, Catherine, additional, Green, Christopher A., additional, Greenwood, Nicola, additional, Harrison, Daisy, additional, Hart, Thomas C., additional, Hawkins, Sophia, additional, Heath, Paul T., additional, Hill, Helen, additional, Hillson, Kushalinii, additional, Horsington, Bryn, additional, Hou, Mimi M., additional, Howe, Elizabeth, additional, Howell, Nicola, additional, Joe, Carina, additional, Jones, Elizabeth, additional, Kasanyinga, Mwila, additional, Keen, Jade, additional, Kelly, Sarah, additional, Kerr, David, additional, Khan, Liaquat, additional, Khozoee, Baktash, additional, Kinch, Jasmin, additional, Kinch, Patrick, additional, Koleva, Stanislava, additional, Kwok, Jonathan, additional, Larkworthy, Colin W., additional, Lawrie, Alison M., additional, Lazarus, Rajeka, additional, Lees, Emily A., additional, Li, Grace, additional, Libri, Vincenzo, additional, Lillie, Patrick J., additional, Linder, Aline, additional, Long, Fei, additional, Lopez Ramon, Raquel, additional, Mabbett, Reece, additional, Makinson, Rebecca, additional, Marinou, Spyridoula, additional, Marlow, Emma, additional, Marshall, Julia L., additional, Mazur, Olga, additional, McEwan, Joanne, additional, McGregor, Alastair C., additional, Mokaya, Jolynne, additional, Morey, Ella, additional, Morshead, Gertraud, additional, Morter, Richard, additional, Muller, Jilly, additional, Mweu, Philomena, additional, Noristani, Rabiullah, additional, Owino, Nelly, additional, Polo Peralta Alvarez, Marco, additional, Platt, Abigail, additional, Pollock, Katrina M., additional, Poulton, Ian, additional, Provstgaard-Morys, Samuel, additional, Pulido-Gomez, David, additional, Rajan, Matthew, additional, Ramos Lopez, Fernando, additional, Ritchie, Adam, additional, Roberts, Hannah, additional, Rollier, Christine, additional, Rudiansyah, Indra, additional, Sanders, Katherine, additional, Saunders, Jack E., additional, Seddiqi, Samiullah, additional, Sharpe, Hannah R., additional, Shaw, Robert, additional, Silva-Reyes, Laura, additional, Singh, Nisha, additional, Smith, David J., additional, Smith, Catherine C., additional, Smith, Andrew, additional, Spencer, Alexandra J., additional, Stuart, Arabella S.V., additional, Sutherland, Rebecca, additional, Szigeti, Anna, additional, Tang, Karly, additional, Thomas, Merin, additional, Thomas, Tonia M., additional, Thompson, Amber, additional, Thomson, Emma C., additional, Török, Estée M., additional, Toshner, Mark, additional, Tran, Nguyen, additional, Trivett, Rose, additional, Turnbull, Iain, additional, Turner, Cheryl, additional, Turner, David P.J., additional, Ulaszewska, Marta, additional, Vichos, Iason, additional, Walker, Laura, additional, Watson, Marion E., additional, Whelan, Conor, additional, White, Rachel, additional, Williams, Sarah J., additional, Williams, Christopher J.A., additional, Wright, Daniel, additional, and Yao, Andy, additional
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- 2021
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39. Safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 in HIV infection: a single-arm substudy of a phase 2/3 clinical trial
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Frater, John, primary, Ewer, Katie J, additional, Ogbe, Ane, additional, Pace, Mathew, additional, Adele, Sandra, additional, Adland, Emily, additional, Alagaratnam, Jasmini, additional, Aley, Parvinder K, additional, Ali, Mohammad, additional, Ansari, M Azim, additional, Bara, Anna, additional, Bittaye, Mustapha, additional, Broadhead, Samantha, additional, Brown, Anthony, additional, Brown, Helen, additional, Cappuccini, Federica, additional, Cooney, Enya, additional, Dejnirattisai, Wanwisa, additional, Dold, Christina, additional, Fairhead, Cassandra, additional, Fok, Henry, additional, Folegatti, Pedro M, additional, Fowler, Jamie, additional, Gibbs, Charlotte, additional, Goodman, Anna L, additional, Jenkin, Daniel, additional, Jones, Mathew, additional, Makinson, Rebecca, additional, Marchevsky, Natalie G, additional, Mujadidi, Yama F, additional, Nguyen, Hanna, additional, Parolini, Lucia, additional, Petersen, Claire, additional, Plested, Emma, additional, Pollock, Katrina M, additional, Ramasamy, Maheshi N, additional, Rhead, Sarah, additional, Robinson, Hannah, additional, Robinson, Nicola, additional, Rongkard, Patpong, additional, Ryan, Fiona, additional, Serrano, Sonia, additional, Tipoe, Timothy, additional, Voysey, Merryn, additional, Waters, Anele, additional, Zacharopoulou, Panagiota, additional, Barnes, Eleanor, additional, Dunachie, Susanna, additional, Goulder, Philip, additional, Klenerman, Paul, additional, Screaton, Gavin R, additional, Winston, Alan, additional, Hill, Adrian V S, additional, Gilbert, Sarah C, additional, Pollard, Andrew J, additional, Fidler, Sarah, additional, Fox, Julie, additional, Lambe, Teresa, additional, Watson, Marion E.E., additional, Song, Rinn, additional, Cicconi, Paola, additional, Minassian, Angela M., additional, Bibi, Sagida, additional, Kerridge, Simon, additional, Singh, Nisha, additional, Green, Catherine M., additional, Douglas, Alexander D., additional, Lawrie, Alison M., additional, and Clutterbuck, Elizabeth A., additional
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- 2021
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40. Controlled human malaria infection with PvW1 – a new clone of Plasmodium vivax with high quality genome assembly
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Minassian, Angela M., primary, Themistocleous, Yrene, additional, Silk, Sarah E., additional, Barrett, Jordan R., additional, Kemp, Alison, additional, Quinkert, Doris, additional, Nielsen, Carolyn M., additional, Edwards, Nick J., additional, Rawlinson, Thomas A., additional, Lopez, Fernando Ramos, additional, Roobsoong, Wanlapa, additional, Ellis, Katherine J., additional, Cho, Jee-Sun, additional, Aunin, Eerik, additional, Otto, Thomas D., additional, Reid, Adam J., additional, Bach, Florian, additional, Labbé, Geneviève M., additional, Poulton, Ian D., additional, Marini, Arianna, additional, Zaric, Marija, additional, Mulatier, Margaux, additional, Ramon, Raquel Lopez, additional, Baker, Megan, additional, Mitton, Celia H., additional, Sousa, Jason C., additional, Rachaphaew, Nattawan, additional, Kumpitak, Chalermpon, additional, Maneechai, Nongnuj, additional, Suansomjit, Chayanut, additional, Piteekan, Tianrat, additional, Hou, Mimi M., additional, Khozoee, Baktash, additional, Roberts, David J., additional, Lawrie, Alison M., additional, Blagborough, Andrew M., additional, Nugent, Fay L., additional, Taylor, Iona J., additional, Johnson, Kimberly J., additional, Spence, Philip J., additional, Sattabongkot, Jetsumon, additional, Biswas, Sumi, additional, Rayner, Julian C., additional, and Draper, Simon J., additional
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- 2021
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41. Safety and Immunogenicity of ChAd63/MVA Pfs25-IMX313 in a Phase I First-in-Human Trial
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de Graaf, Hans, primary, Payne, Ruth O., additional, Taylor, Iona, additional, Miura, Kazutoyo, additional, Long, Carol A., additional, Elias, Sean C., additional, Zaric, Marija, additional, Minassian, Angela M., additional, Silk, Sarah E., additional, Li, Lee, additional, Poulton, Ian D., additional, Baker, Megan, additional, Draper, Simon J., additional, Gbesemete, Diane, additional, Brendish, Nathan J., additional, Martins, Filipa, additional, Marini, Arianna, additional, Mekhaiel, David, additional, Edwards, Nick J., additional, Roberts, Rachel, additional, Vekemans, Johan, additional, Moyle, Sarah, additional, Faust, Saul N., additional, Berrie, Eleanor, additional, Lawrie, Alison M., additional, Hill, Fergal, additional, Hill, Adrian V. S., additional, and Biswas, Sumi, additional
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- 2021
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42. Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK
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Voysey, Merryn, Clemens, Sue Ann Costa, Madhi, Shabir A., Weckx, Lily Y., Folegatti, Pedro M., Aley, Parvinder K., Angus, Brian, Baillie, Vicky L., Barnabas, Shaun L., Bhorat, Qasim E., Bibi, Sagida, Briner, Carmen, Cicconi, Paola, Collins, Andrea M., Colin-Jones, Rachel, Cutland, Clare L., Darton, Thomas C., Dheda, Keertan, Duncan, Christopher J. A., Emary, Katherine R. W., Ewer, Katie J., Fairlie, Lee, Faust, Saul N., Feng, Shuo, Ferreira, Daniela M., Finn, Adam, Goodman, Anna L., Green, Catherine M., Green, Christopher A., Heath, Paul T., Hill, Catherine, Hill, Helen, Hirsch, Ian, Hodgson, Susanne H. C., Izu, Alane, Jackson, Susan, Jenkin, Daniel, Joe, Carina C. D., Kerridge, Simon, Koen, Anthonet, Kwatra, Gaurav, Lazarus, Rajeka, Lawrie, Alison M., Lelliott, Alice, Libri, Vincenzo, Lillie, Patrick J., Mallory, Raburn, Mendes, Ana V. A., Milan, Eveline P., Minassian, Angela M., McGregor, Alastair, Morrison, Hazel, Mujadidi, Yama F., Nana, Anusha, O'Reilly, Peter J., Padayachee, Sherman D., Pittella, Ana, Plested, Emma, Pollock, Katrina M., Ramasamy, Maheshi N., Rhead, Sarah, Schwarzbold, Alexandre V., Singh, Nisha, Smith, Andrew, Song, Rinn, Snape, Matthew D., Sprinz, Eduardo, Sutherland, Rebecca K., Tarrant, Richard, Thomson, Emma C., Török, Mark and Turner, Sorio, Guilherme L., Sorley, Kim, Sosa-Rodriguez, Tiffany, Souza, Cinthia M.C.D.L., Souza, Bruno S.D.F., Souza, Alessandra R., Spencer, Alexandra J., Spina, Fernanda, Spoors, Louise, Stafford, Lizzie, Stamford, Imogen, Starinskij, Igor, Stein, Ricardo, Steven, Jill, Stockdale, Lisa, Stockwell, Lisa V., Strickland, Louise H., Stuart, Arabella C., Sturdy, Ann, Sutton, Natalina, Szigeti, Anna, Tahiri-Alaoui, Abdessamad, Tanner, Rachel, Taoushanis, Carol, Tarr, Alexander W., Taylor, Keja, Taylor, Ursula, Taylor, Iona Jennifer, Taylor, Justin, te Water Naude, Rebecca, Themistocleous, Yrene, Themistocleous, Andreas, Thomas, Merin, Thomas, Kelly, Thomas, Tonia M., Thombrayil, Asha, Thompson, Fawziyah, Thompson, Amber, Thompson, Kevin, Thompson, Ameeka, Thomson, Julia, Thornton-Jones, Viv, Tighe, Patrick J., Tinoco, Lygia Accioly, Tiongson, Gerlynn, Tladinyane, Bonolo, Tomasicchio, Michele, Tomic, Adriana, Tonks, Susan, Tran, Nguyen, Tree, Julia, Trillana, Gerry, Trinham, Charlotte, Trivett, Rose, Truby, Adam, Tsheko, Betty Lebogang, Turabi, Aadil, Turner, Richard, Turner, Cheryl, Ulaszewska, Marta, Underwood, Benjamin R., Varughese, Rachel, Verbart, Dennis, Verheul, Marije, Vichos, Iason, Vieira, Taiane, Waddington, Claire S., Walker, Laura, Wallis, Erica, Wand, Matthew, Warbick, Deborah, Wardell, Theresa, Warimwe, George, Warren, Sarah C., Watkins, Bridget, Watson, Ekaterina, Webb, Stewart, Webb-Bridges, Alice, Webster, Angela, Welch, Jessica, Wells, Jeanette, West, Alison, White, Caroline, White, Rachel, Williams, Paul, Williams, Rachel L., Winslow, Rebecca, Woodyer, Mark, Worth, Andrew T., Wright, Danny, Wroblewska, Marzena, Yao, Andy, Zimmer, Rafael, Zizi, Dalila, and Zuidewind, Peter
- Abstract
Background: \ud A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials.\ud \ud Methods: \ud This analysis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil, and South Africa. Participants aged 18 years and older were randomly assigned (1:1) to ChAdOx1 nCoV-19 vaccine or control (meningococcal group A, C, W, and Y conjugate vaccine or saline). Participants in the ChAdOx1 nCoV-19 group received two doses containing 5 × 1010 viral particles (standard dose; SD/SD cohort); a subset in the UK trial received a half dose as their first dose (low dose) and a standard dose as their second dose (LD/SD cohort). The primary efficacy analysis included symptomatic COVID-19 in seronegative participants with a nucleic acid amplification test-positive swab more than 14 days after a second dose of vaccine. Participants were analysed according to treatment received, with data cutoff on Nov 4, 2020. Vaccine efficacy was calculated as 1 - relative risk derived from a robust Poisson regression model adjusted for age. Studies are registered at ISRCTN89951424 and ClinicalTrials.gov, NCT04324606, NCT04400838, and NCT04444674.\ud \ud Findings: \ud Between April 23 and Nov 4, 2020, 23 848 participants were enrolled and 11 636 participants (7548 in the UK, 4088 in Brazil) were included in the interim primary efficacy analysis. In participants who received two standard doses, vaccine efficacy was 62·1% (95% CI 41·0–75·7; 27 [0·6%] of 4440 in the ChAdOx1 nCoV-19 group vs71 [1·6%] of 4455 in the control group) and in participants who received a low dose followed by a standard dose, efficacy was 90·0% (67·4–97·0; three [0·2%] of 1367 vs 30 [2·2%] of 1374; pinteraction=0·010). Overall vaccine efficacy across both groups was 70·4% (95·8% CI 54·8–80·6; 30 [0·5%] of 5807 vs 101 [1·7%] of 5829). From 21 days after the first dose, there were ten cases hospitalised for COVID-19, all in the control arm; two were classified as severe COVID-19, including one death. There were 74 341 person-months of safety follow-up (median 3·4 months, IQR 1·3–4·8): 175 severe adverse events occurred in 168 participants, 84 events in the ChAdOx1 nCoV-19 group and 91 in the control group. Three events were classified as possibly related to a vaccine: one in the ChAdOx1 nCoV-19 group, one in the control group, and one in a participant who remains masked to group allocation.\ud \ud Interpretation: \ud ChAdOx1 nCoV-19 has an acceptable safety profile and has been found to be efficacious against symptomatic COVID-19 in this interim analysis of ongoing clinical trials.\ud \ud Funding: \ud UK Research and Innovation, National Institutes for Health Research (NIHR), Coalition for Epidemic Preparedness Innovations, Bill & Melinda Gates Foundation, Lemann Foundation, Rede D’Or, Brava and Telles Foundation, NIHR Oxford Biomedical Research Centre, Thames Valley and South Midland's NIHR Clinical Research Network, and AstraZeneca.
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- 2021
43. Efficacy of a low-dose candidate malaria vaccine, R21 in adjuvant Matrix-M, with seasonal administration to children in Burkina Faso: a randomised controlled trial.
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Datoo, Mehreen MS, Natama, Hamtandi Magloire, Somé, Athanase, Traoré, Ousmane, Rouamba, Toussaint, Bellamy, Duncan, Yameogo, Prisca, Valia, Daniel, Tegneri, Moubarak, Ouedraogo, Florence, Soma, Rachidatou, Sawadogo, Seydou, Sorgho, Faizatou, Derra, Karim, Rouamba, Eli, Orindi, Benedict, Ramos Lopez, Fernando, Flaxman, Amy, Cappuccini, Federica, Kailath, Reshma, Elias, Sean, Mukhopadhyay, Ekta, Noe, Andres, Cairns, Matthew, Lawrie, Alison, Roberts, Rachel, Valéa, Innocent, Sorgho, Hermann, Williams, Nicola, Glenn, Gregory, Fries, Louis, Reimer, Jenny, Ewer, Katie KJ, Shaligram, Umesh, Hill, Adrian V S, Tinto, Halidou, Datoo, Mehreen MS, Natama, Hamtandi Magloire, Somé, Athanase, Traoré, Ousmane, Rouamba, Toussaint, Bellamy, Duncan, Yameogo, Prisca, Valia, Daniel, Tegneri, Moubarak, Ouedraogo, Florence, Soma, Rachidatou, Sawadogo, Seydou, Sorgho, Faizatou, Derra, Karim, Rouamba, Eli, Orindi, Benedict, Ramos Lopez, Fernando, Flaxman, Amy, Cappuccini, Federica, Kailath, Reshma, Elias, Sean, Mukhopadhyay, Ekta, Noe, Andres, Cairns, Matthew, Lawrie, Alison, Roberts, Rachel, Valéa, Innocent, Sorgho, Hermann, Williams, Nicola, Glenn, Gregory, Fries, Louis, Reimer, Jenny, Ewer, Katie KJ, Shaligram, Umesh, Hill, Adrian V S, and Tinto, Halidou
- Abstract
Stalled progress in controlling Plasmodium falciparum malaria highlights the need for an effective and deployable vaccine. RTS,S/AS01, the most effective malaria vaccine candidate to date, demonstrated 56% efficacy over 12 months in African children. We therefore assessed a new candidate vaccine for safety and efficacy., info:eu-repo/semantics/published
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- 2021
44. T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial
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Ewer, Katie J., Barrett, Jordan R., Belij-Rammerstorfer, Sandra, Sharpe, Hannah, Makinson, Rebecca, Morter, Richard, Flaxman, Amy, Wright, Daniel, Bellamy, Duncan, Bittaye, Mustapha, Dold, Christina, Provine, Nicholas M., Aboagye, Jeremy, Fowler, Jamie, Silk, Sarah E., Alderson, Jennifer, Aley, Parvinder K., Angus, Brian, Berrie, Eleanor, Bibi, Sagida, Cicconi, Paola, Clutterbuck, Elizabeth A., Chelysheva, Irina, Folegatti, Pedro M., Fuskova, Michelle, Green, Catherine M., Jenkin, Daniel, Kerridge, Simon, Lawrie, Alison, Minassian, Angela M., Moore, Maria, Mujadidi, Yama, Plested, Emma, Poulton, Ian, Ramasamy, Maheshi N., Robinson, Hannah, Song, Rinn, Snape, Matthew D., Tarrant, Richard, Voysey, Merryn, Watson, Marion E. E., Douglas, Alexander D., Hill, Adrian V. S., Gilbert, Sarah C., Pollard, Andrew J., Lambe, Teresa, Ali, Aabidah, Allen, Elizabeth, Baker, Megan, Barnes, Eleanor, Borthwick, Nicola, Boyd, Amy, Brown-O’Sullivan, Charlie, Burgoyne, Joshua, Byard, Nicholas, Puig, Ingrid Cabrera, Cappuccini, Federica, Cho, Jee-Sun, Clark, Elizabeth, Crocker, Wendy E. M., Datoo, Mehreen S., Davies, Hannah, Donnellan, Francesca R., Dunachie, Susanna Jane, Edwards, Nick J., Elias, Sean C., Furze, Julie, Gilbride, Ciaran, Gorini, Giacomo, Gupta, Gaurav, Harris, Stephanie A., Hodgson, Susanne H. C., Hou, Mimi M., Jackson, Susan, Jones, Kathryn, Kailath, Reshma, King, Lloyd, Larkworthy, Colin W., Li, Yuanyuan, Lias, Amelia M., Linder, Aline, Lipworth, Samuel, Ramon, Raquel Lopez, Madhavan, Meera, Marlow, Emma, Marshall, Julia L., Mentzer, Alexander J., Morrison, Hazel, Moya, Nathifa, Mukhopadhyay, Ekta, Noé, Andrés, Nugent, Fay L., Pipini, Dimitra, Pulido-Gomez, David, Lopez, Fernando Ramos, Ritchie, Adam John, Rudiansyah, Indra, Salvador, Stephannie, Sanders, Helen, Satti, Iman, Shea, Adam, Silk, Sarah, Spencer, Alexandra J., Tanner, Rachel, Taylor, Iona Jennifer, Themistocleous, Yrene, Thomas, Merin, Tran, Nguyen, Truby, Adam, Turner, Cheryl, Turner, Nicola, Ulaszewska, Marta, Worth, Andrew T., Kingham-Page, Lucy, Alvarez, Marco Polo Peralta, Anslow, Rachel, Bates, Louise, Beadon, Kirsten, Beckley, Rebecca, Beveridge, Amy, Bijker, Else Margreet, Blackwell, Luke, Burbage, Jamie, Camara, Susana, Carr, Melanie, Colin-Jones, Rachel, Cooper, Rachel, Cunningham, Christina J., Demissie, Tesfaye, Maso, Claudio Di, Douglas, Naomi, Drake-Brockman, Rachael, Drury, Ruth Elizabeth, Emary, Katherine R. W., Felle, Sally, Feng, Shuo, Silva, Carla Ferreira Da, Ford, Karen J., Francis, Emma, Gracie, Lara, Hamlyn, Joseph, Hanumunthadu, Brama, Harrison, Daisy, Hart, Thomas C., Hawkins, Sophia, Hill, Jennifer, Howe, Elizabeth, Howell, Nicola, Jones, Elizabeth, Keen, Jade, Kelly, Sarah, Kerr, David, Khan, Liaquat, Kinch, Jasmin, Koleva, Stanislava, Lees, Emily A., Lelliott, Alice, Liu, Xinxue, Marchevsky, Natalie G., Marinou, Spyridoula, McEwan, Joanne, Morey, Ella, Morshead, Gertraud, Muller, Jilly, Munro, Claire, Murphy, Sarah, Mweu, Philomena, Nuthall, Elizabeth, O’Brien, Katie, O’Connor, Daniel, O’Reilly, Peter John, Oguti, Blanché, Osborne, Piper, Owino, Nelly, Parker, Kaye, Pfafferott, Katja, Phillips, Daniel, Provstgaard-Morys, Samuel, Ratcliffe, Helen, Rawlinson, Thomas, Rhead, Sarah, Roberts, Hannah, Sanders, Katherine, Silva-Reyes, Laura, Rollier, Christine S., Smith, Catherine C., Smith, David J., Stockdale, Lisa, Szigeti, Anna, Thomas, Tonia M., Thompson, Amber, Tomic, Adriana, Tonks, Susan, Varughese, Rachel, Verheul, Marije K., Vichos, Iason, Walker, Laura, White, Caroline, White, Rachel, Yao, Xin Li, Conlon, Christopher P., Frater, John, Cifuentes, Liliana, Baleanu, Ioana, Bolam, Emma, Boland, Elena, Brenner, Tanja, Damratoski, Brad E., Datta, Chandra, Muhanna, Omar El, Fisher, Richard, Galian-Rubio, Pablo, Hodges, Gina, Jackson, Frederic, Liu, Shuchang, Loew, Lisa, Morgans, Roisin, Morris, Susan Jane, Olchawski, Vicki, Oliveria, Catarina, Parracho, Helena, Pabon, Emilia Reyes, Tahiri-Alaoui, Abdessamad, Taylor, Keja, Williams, Paul, Zizi, Dalila, Arbe-Barnes, Edward H., Baker, Philip, Batten, Alexander, Downing, Charlotte, Drake, Jonathan, English, Marcus Rex, Henry, John Aaron, Iveson, Poppy, Killen, Annabel, King, Thomas B., Larwood, Jessica P. J., Mallett, Garry, Mansatta, Kushal, Mirtorabi, Neginsadat, Patrick-Smith, Maia, Perring, James, Radia, Kajal, Roche, Sophie, Schofield, Ella, Naude, Rebecca te Water, Towner, James, Baker, Natalie, Bewley, Kevin R., Brunt, Emily, Buttigieg, Karen R., Carroll, Miles W., Charlton, Sue, Coombes, Naomi S., Elmore, Michael J., Godwin, Kerry, Hallis, Bassam, Knott, Daniel, McInroy, Lorna, Shaik, Imam, Thomas, Kelly, Tree, Julia A., Blundell, Caitlin L., Cao, Michelangelo, Kelly, Dearbhla, Schmid, Annina, Skelly, Donal T., Themistocleous, Andreas, Dong, Tao, Field, Samantha, Hamilton, Elizabeth, Kelly, Elizabeth, Klenerman, Paul, Knight, Julian C., Lie, Yolanda, Petropoulos, Christos, Sedik, Cynthia, Wrin, Terri, Meddaugh, Gretchen, Peng, Yanchun, Screaton, Gavin, and Stafford, Elizabeth
- Subjects
0301 basic medicine ,biology ,business.industry ,T cell ,Immunogenicity ,General Medicine ,Vaccine efficacy ,General Biochemistry, Genetics and Molecular Biology ,Vaccination ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,medicine.anatomical_structure ,Immune system ,Immunity ,030220 oncology & carcinogenesis ,Immunology ,biology.protein ,medicine ,Cytotoxic T cell ,Antibody ,business - Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus Disease 2019 (COVID-19), has caused a global pandemic, and safe, effective vaccines are urgently needed1. Strong, Th1-skewed T cell responses can drive protective humoral and cell-mediated immune responses2 and might reduce the potential for disease enhancement3. Cytotoxic T cells clear virus-infected host cells and contribute to control of infection4. Studies of patients infected with SARS-CoV-2 have suggested a protective role for both humoral and cell-mediated immune responses in recovery from COVID-19 (refs. 5,6). ChAdOx1 nCoV-19 (AZD1222) is a candidate SARS-CoV-2 vaccine comprising a replication-deficient simian adenovirus expressing full-length SARS-CoV-2 spike protein. We recently reported preliminary safety and immunogenicity data from a phase 1/2 trial of the ChAdOx1 nCoV-19 vaccine (NCT04400838)7 given as either a one- or two-dose regimen. The vaccine was tolerated, with induction of neutralizing antibodies and antigen-specific T cells against the SARS-CoV-2 spike protein. Here we describe, in detail, exploratory analyses of the immune responses in adults, aged 18–55 years, up to 8 weeks after vaccination with a single dose of ChAdOx1 nCoV-19 in this trial, demonstrating an induction of a Th1-biased response characterized by interferon-γ and tumor necrosis factor-α cytokine secretion by CD4+ T cells and antibody production predominantly of IgG1 and IgG3 subclasses. CD8+ T cells, of monofunctional, polyfunctional and cytotoxic phenotypes, were also induced. Taken together, these results suggest a favorable immune profile induced by ChAdOx1 nCoV-19 vaccine, supporting the progression of this vaccine candidate to ongoing phase 2/3 trials to assess vaccine efficacy. A single dose of the ChAdOx1 nCoV-19 vaccine elicits antibodies and cytokine-producing T cells that might help control or prevent SARS-CoV-2 infection.
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- 2020
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45. Efficacy of a low-dose candidate malaria vaccine, R21 in adjuvant Matrix-M, with seasonal administration to children in Burkina Faso: a randomised controlled trial
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Datoo, Mehreen S, primary, Natama, Magloire H, additional, Somé, Athanase, additional, Traoré, Ousmane, additional, Rouamba, Toussaint, additional, Bellamy, Duncan, additional, Yameogo, Prisca, additional, Valia, Daniel, additional, Tegneri, Moubarak, additional, Ouedraogo, Florence, additional, Soma, Rachidatou, additional, Sawadogo, Seydou, additional, Sorgho, Faizatou, additional, Derra, Karim, additional, Rouamba, Eli, additional, Orindi, Benedict, additional, Ramos Lopez, Fernando, additional, Flaxman, Amy, additional, Cappuccini, Federica, additional, Kailath, Reshma, additional, Elias, Sean, additional, Mukhopadhyay, Ekta, additional, Noe, Andres, additional, Cairns, Matthew, additional, Lawrie, Alison, additional, Roberts, Rachel, additional, Valéa, Innocent, additional, Sorgho, Hermann, additional, Williams, Nicola, additional, Glenn, Gregory, additional, Fries, Louis, additional, Reimer, Jenny, additional, Ewer, Katie J, additional, Shaligram, Umesh, additional, Hill, Adrian V S, additional, and Tinto, Halidou, additional
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- 2021
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46. Phase I Trial Evaluating the Safety and Immunogenicity of Candidate TB Vaccine MVA85A, Delivered by Aerosol to Healthy M.tb-Infected Adults
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Riste, Michael, primary, Marshall, Julia L., additional, Satti, Iman, additional, Harris, Stephanie A., additional, Wilkie, Morven, additional, Lopez Ramon, Raquel, additional, Wright, Danny, additional, Wittenberg, Rachel E., additional, Vermaak, Samantha, additional, Powell Doherty, Rebecca, additional, Lawrie, Alison, additional, Conlon, Christopher P., additional, Cosgrove, Catherine, additional, Gleeson, Fergus, additional, Lipman, Marc, additional, Moss, Paul, additional, Perrin, Felicity, additional, Dedicoat, Martin, additional, Bettinson, Henry, additional, and McShane, Helen, additional
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- 2021
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47. Safety and Immunogenicity of Adenovirus and Poxvirus Vectored Vaccines against a Mycobacterium Avium Complex Subspecies
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Folegatti, Pedro M., primary, Flaxman, Amy, additional, Jenkin, Daniel, additional, Makinson, Rebecca, additional, Kingham-Page, Lucy, additional, Bellamy, Duncan, additional, Ramos Lopez, Fernando, additional, Sheridan, Jonathan, additional, Poulton, Ian, additional, Aboagye, Jeremy, additional, Tran, Nguyen, additional, Mitton, Celia, additional, Roberts, Rachel, additional, Lawrie, Alison M., additional, Hill, Adrian V. S., additional, Ewer, Katie J., additional, and Gilbert, Sarah, additional
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- 2021
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48. Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials
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Voysey, Merryn, primary, Costa Clemens, Sue Ann, additional, Madhi, Shabir A, additional, Weckx, Lily Y, additional, Folegatti, Pedro M, additional, Aley, Parvinder K, additional, Angus, Brian, additional, Baillie, Vicky L, additional, Barnabas, Shaun L, additional, Bhorat, Qasim E, additional, Bibi, Sagida, additional, Briner, Carmen, additional, Cicconi, Paola, additional, Clutterbuck, Elizabeth A, additional, Collins, Andrea M, additional, Cutland, Clare L, additional, Darton, Thomas C, additional, Dheda, Keertan, additional, Dold, Christina, additional, Duncan, Christopher J A, additional, Emary, Katherine R W, additional, Ewer, Katie J, additional, Flaxman, Amy, additional, Fairlie, Lee, additional, Faust, Saul N, additional, Feng, Shuo, additional, Ferreira, Daniela M, additional, Finn, Adam, additional, Galiza, Eva, additional, Goodman, Anna L, additional, Green, Catherine M, additional, Green, Christopher A, additional, Greenland, Melanie, additional, Hill, Catherine, additional, Hill, Helen C, additional, Hirsch, Ian, additional, Izu, Alane, additional, Jenkin, Daniel, additional, Joe, Carina C D, additional, Kerridge, Simon, additional, Koen, Anthonet, additional, Kwatra, Gaurav, additional, Lazarus, Rajeka, additional, Libri, Vincenzo, additional, Lillie, Patrick J, additional, Marchevsky, Natalie G, additional, Marshall, Richard P, additional, Mendes, Ana V A, additional, Milan, Eveline P, additional, Minassian, Angela M, additional, McGregor, Alastair, additional, Mujadidi, Yama F, additional, Nana, Anusha, additional, Padayachee, Sherman D, additional, Phillips, Daniel J, additional, Pittella, Ana, additional, Plested, Emma, additional, Pollock, Katrina M, additional, Ramasamy, Maheshi N, additional, Ritchie, Adam J, additional, Robinson, Hannah, additional, Schwarzbold, Alexandre V, additional, Smith, Andrew, additional, Song, Rinn, additional, Snape, Matthew D, additional, Sprinz, Eduardo, additional, Sutherland, Rebecca K, additional, Thomson, Emma C, additional, Török, M Estée, additional, Toshner, Mark, additional, Turner, David P J, additional, Vekemans, Johan, additional, Villafana, Tonya L, additional, White, Thomas, additional, Williams, Christopher J, additional, Douglas, Alexander D, additional, Hill, Adrian V S, additional, Lambe, Teresa, additional, Gilbert, Sarah C, additional, Pollard, Andrew J, additional, Aban, Marites, additional, Abeyskera, Kushala W.M., additional, Aboagye, Jeremy, additional, Adam, Matthew, additional, Adams, Kirsty, additional, Adamson, James P., additional, Adewatan, Gbadebo, additional, Adlou, Syed, additional, Ahmed, Khatija, additional, Akhalwaya, Yasmeen, additional, Akhalwaya, Saajida, additional, Alcock, Andrew, additional, Ali, Aabidah, additional, Allen, Elizabeth R., additional, Allen, Lauren, additional, Alvernaz, Felipe B., additional, Amorim, Fabio Santos, additional, Andrade, Claudia Sala, additional, Andritsou, Foteini, additional, Anslow, Rachel, additional, Arbe-Barnes, Edward H., additional, Ariaans, Mark P., additional, Arns, Beatriz, additional, Arruda, Laiana, additional, Assad, Luiza, additional, Azi, Paula De Almeida, additional, Azi, Lorena De Almeida, additional, Babbage, Gavin, additional, Bailey, Catherine, additional, Baker, Kenneth F., additional, Baker, Megan, additional, Baker, Natalie, additional, Baker, Philip, additional, Baleanu, Ioana, additional, Bandeira, Danieli, additional, Bara, Anna, additional, Barbosa, Marcella A.S., additional, Barker, Debbie, additional, Barlow, Gavin D., additional, Barnes, Eleanor, additional, Barr, Andrew S., additional, Barrett, Jordan R., additional, Barrett, Jessica, additional, Barrett, Kelly, additional, Bates, Louise, additional, Batten, Alexander, additional, Beadon, Kirsten, additional, Beales, Emily, additional, Beckley, Rebecca, additional, Belij-Rammerstorfer, Sandra, additional, Bell, Jonathan, additional, Bellamy, Duncan, additional, Belton, Sue, additional, Berg, Adam, additional, Bermejo, Laura, additional, Berrie, Eleanor, additional, Berry, Lisa, additional, Berzenyi, Daniella, additional, Beveridge, Amy, additional, Bewley, Kevin R., additional, Bharaj, Inderjeet, additional, Bhikha, Sutika, additional, Bhorat, Asad E., additional, Bhorat, Zaheda E., additional, Bijker, Else Margreet, additional, Birch, Sarah, additional, Birch, Gurpreet, additional, Birchall, Kathryn, additional, Bird, Adam, additional, Bird, Olivia, additional, Bisnauthsing, Karen, additional, Bittaye, Mustapha, additional, Blackwell, Luke, additional, Blacow, Rachel, additional, Bletchly, Heather, additional, Blundell, Caitlin L., additional, Blundell, Susannah R., additional, Bodalia, Pritesh, additional, Bolam, Emma, additional, Boland, Elena, additional, Bormans, Daan, additional, Borthwick, Nicola, additional, Bowring, Francesca, additional, Boyd, Amy, additional, Bradley, Penny, additional, Brenner, Tanja, additional, Bridges-Webb, Alice, additional, Brown, Phillip, additional, Brown, Claire, additional, Brown-O'Sullivan, Charlie, additional, Bruce, Scott, additional, Brunt, Emily, additional, Budd, William, additional, Bulbulia, Yusuf A., additional, Bull, Melanie, additional, Burbage, Jamie, additional, Burn, Aileen, additional, Buttigieg, Karen R., additional, Byard, Nicholas, additional, Cabrera Puig, Ingrid, additional, Calvert, Anna, additional, Camara, Susana, additional, Cao, Michelangelo, additional, Cappuccini, Federica, additional, Cardona, Rita, additional, Cardoso, João R., additional, Carr, Melanie, additional, Carroll, Miles W., additional, Carson-Stevens, Andrew, additional, Carvalho, Yasmin de M., additional, Casey, Helen R., additional, Cashen, Paul, additional, Castro, Thais R.Y., additional, Castro, Lucia Carratala, additional, Cathie, Katrina, additional, Cavey, Ana, additional, Cerbino-Neto, José, additional, Cezar, Luiz Fernando F., additional, Chadwick, Jim, additional, Chanice, Chanice, additional, Chapman, David, additional, Charlton, Sue, additional, Cheliotis, Katerina S., additional, Chelysheva, Irina, additional, Chester, Oliver, additional, Chiplin, Emily, additional, Chita, Sunder, additional, Cho, Jee-Sun, additional, Cifuentes, Liliana, additional, Clark, Elizabeth, additional, Clark, Matthew, additional, Colin-Jones, Rachel, additional, Collins, Sarah L.K., additional, Colton, Hayley, additional, Conlon, Christopher P., additional, Connarty, Sean, additional, Coombes, Naomi, additional, Cooper, Cushla, additional, Cooper, Rachel, additional, Cornelissen, Lynne, additional, Corrah, Tumena, additional, Cosgrove, Catherine A., additional, Costa, Fernanda Barroso, additional, Cox, Tony, additional, Crocker, Wendy E.M., additional, Crosbie, Sarah, additional, Cullen, Dan, additional, Cunha, Debora R.M.F., additional, Cunningham, Christina J., additional, Cuthbertson, Fiona C., additional, da Costa, Daniel Marinho, additional, Da Guarda, Suzete N. Farias, additional, da Silva, Larissa P., additional, da Silva Moraes, Antonio Carlos, additional, Damratoski, Brad E., additional, Danos, Zsofia, additional, Dantas, Maria T.D.C., additional, Datoo, Mehreen S., additional, Datta, Chandrabali, additional, Davids, Malika, additional, Davies, Sarah L., additional, Davies, Kelly, additional, Davies, Hannah, additional, Davies, Sophie, additional, Davies, Judith, additional, Davis, Elizabeth J., additional, Davis, John, additional, de Carvalho, José A.M., additional, De Jager, Jeanne, additional, de Jesus Jnr, Sergio, additional, De Oliveira Kalid, Lis Moreno, additional, Dearlove, David, additional, Demissie, Tesfaye, additional, Desai, Amisha, additional, Di Marco, Stefania, additional, Di Maso, Claudio, additional, Dinesh, Tanya, additional, Docksey, Claire, additional, Dong, Tao, additional, Donnellan, Francesca R., additional, Dos Santos, Tannyth Gomes, additional, Dos Santos, Thainá G., additional, Dos Santos, Erika Pachecho, additional, Douglas, Naomi, additional, Downing, Charlotte, additional, Drake, Jonathan, additional, Drake-Brockman, Rachael, additional, Drury, Ruth, additional, Du Plessis, Joan, additional, Dunachie, Susanna J., additional, Duncan, Andrew, additional, Easom, Nicholas J.W., additional, Edwards, Mandy, additional, Edwards, Nick J., additional, Edwards, Frances, additional, El Muhanna, Omar M., additional, Elias, Sean C., additional, Ellison-Handley, Branwen, additional, Elmore, Michael J., additional, English, Marcus Rex, additional, Esmail, Alisgair, additional, Essack, Yakub Moosa, additional, Farooq, Mutjaba, additional, Fedosyuk, Sofiya, additional, Felle, Sally, additional, Ferguson, Susie, additional, Ferreira Da Silva, Carla, additional, Field, Samantha, additional, Fisher, Richard, additional, Fletcher, James, additional, Fofie, Hazel, additional, Fok, Henry, additional, Ford, Karen J., additional, Fothergill, Ross, additional, Fowler, Jamie, additional, Fraiman, Pedro H.A., additional, Francis, Emma, additional, Franco, Marilia M., additional, Frater, John, additional, Freire, Marilúcia S.M., additional, Fry, Samantha H., additional, Fudge, Sabrina, additional, Furlan Filho, Renato, additional, Furze, Julie, additional, Fuskova, Michelle, additional, Galian-Rubio, Pablo, additional, Garlant, Harriet, additional, Gavrila, Madita, additional, Gibbons, Karyna A., additional, Gilbride, Ciaran, additional, Gill, Hardeep, additional, Godwin, Kerry, additional, Gokani, Karishma, additional, Gonçalves, Maria Luisa Freire, additional, Gonzalez, Isabela G.S., additional, Goodall, Jack, additional, Goodwin, Jayne, additional, Goondiwala, Amina, additional, Gordon-Quayle, Katherine, additional, Gorini, Giacomo, additional, Goyanna, Alvaro, additional, Grab, Janet, additional, Gracie, Lara, additional, Green, Justin, additional, Greenwood, Nicola, additional, Greffrath, Johann, additional, Groenewald, Marisa M., additional, Gunawardene, Anishka, additional, Gupta, Gaurav, additional, Hackett, Mark, additional, Hallis, Bassam, additional, Hamaluba, Mainga, additional, Hamilton, Elizabeth, additional, Hamlyn, Joseph, additional, Hammersley, Daniel, additional, Hanrath, Aidan T., additional, Hanumunthadu, Brama, additional, Harris, Stephanie A., additional, Harris, Clair, additional, Harrison, Thomas D., additional, Harrison, Daisy, additional, Harris-Wright, Tara A., additional, Hart, Thomas C., additional, Hartnell, Birgit, additional, Haughney, John, additional, Hawkins, Sophia, additional, Hayano, Laís Y.M., additional, Head, Ian, additional, Heath, Paul T., additional, Henry, John Aaron, additional, Hermosin Herrera, Macarena, additional, Hettle, David B., additional, Higa, Cristhiane, additional, Hill, Jennifer, additional, Hodges, Gina, additional, Hodgson, Susanne, additional, Horne, Elizea, additional, Hou, Mimi M., additional, Houlihan, Catherine F., additional, Howe, Elizabeth, additional, Howell, Nicola, additional, Humphreys, Jonathan, additional, Humphries, Holly E., additional, Hurley, Katrina, additional, Huson, Claire, additional, Hyams, Catherine, additional, Hyder-Wright, Angela, additional, Ikram, Sabina, additional, Ishwarbhai, Alka, additional, Iveson, Poppy, additional, Iyer, Vidyashankara, additional, Jackson, Frederic, additional, Jackson, Susan, additional, Jaumdally, Shameem, additional, Jeffers, Helen, additional, Jesudason, Natasha, additional, Jones, Carina, additional, Jones, Christopher, additional, Jones, Kathryn, additional, Jones, Elizabeth, additional, Jorge, Marianna Rocha, additional, Joshi, Amar, additional, Júnior, Eduardo A.M.S., additional, Kailath, Reshma, additional, Kana, Faeeza, additional, Kar, Arnab, additional, Karampatsas, Konstantinos, additional, Kasanyinga, Mwila, additional, Kay, Linda, additional, Keen, Jade, additional, Kellett Wright, Johanna, additional, Kelly, Elizabeth J., additional, Kelly, Debbie, additional, Kelly, Dearbhla M., additional, Kelly, Sarah, additional, Kerr, David, additional, Khan, Liaquat, additional, Khozoee, Baktash, additional, Khurana, Ankush, additional, Kidd, Sarah, additional, Killen, Annabel, additional, Kinch, Jasmin, additional, Kinch, Patrick, additional, King, Lloyd D.W., additional, King, Thomas B., additional, Kingham, Lucy, additional, Klenerman, Paul, additional, Kluczna, Diana M., additional, Knapper, Francesca, additional, Knight, Julian C., additional, Knott, Daniel, additional, Koleva, Stanislava, additional, Lages, Pedro M., additional, Lang, Matilda, additional, Lang, Gail, additional, Larkworthy, Colin W., additional, Larwood, Jessica P.J., additional, Law, Rebecca, additional, Lawrie, Alison M., additional, Lazarus, Erica M., additional, Leach, Amanda, additional, Lees, Emily A., additional, Lelliott, Alice, additional, Lemm, Nana-Marie, additional, Lessa, Alvaro Edson Ramos, additional, Leung, Stephanie, additional, Li, Yuanyuan, additional, Lias, Amelia M., additional, Liatsikos, Konstantinos, additional, Linder, Aline, additional, Lipworth, Samuel, additional, Liu, Shuchang, additional, Liu, Xinxue, additional, Lloyd, Adam, additional, Lloyd, Stephanie, additional, Loew, Lisa, additional, Lopez Ramon, Raquel, additional, Lora, Leandro Bonecker, additional, Luz, Kleber Giovanni, additional, MacDonald, Jonathan C., additional, MacGregor, Gordon, additional, Madhavan, Meera, additional, Mainwaring, David O., additional, Makambwa, Edson, additional, Makinson, Rebecca, additional, Malahleha, Mookho, additional, Malamatsho, Ross, additional, Mallett, Garry, additional, Manning, Nicola, additional, Mansatta, Kushal, additional, Maoko, Takalani, additional, Marinou, Spyridoula, additional, Marlow, Emma, additional, Marques, Gabriela N., additional, Marriott, Paula, additional, Marshall, Richard P., additional, Marshall, Julia L., additional, Masenya, Masebole, additional, Masilela, Mduduzi, additional, Masters, Shauna K., additional, Mathew, Moncy, additional, Matlebjane, Hosea, additional, Matshidiso, Kedidimetse, additional, Mazur, Olga, additional, Mazzella, Andrea, additional, McCaughan, Hugh, additional, McEwan, Joanne, additional, McGlashan, Joanna, additional, McInroy, Lorna, additional, McRobert, Nicky, additional, McSwiggan, Steve, additional, Megson, Clare, additional, Mehdipour, Savviz, additional, Meijs, Wilma, additional, Mendonça, Renata N.Õ., additional, Mentzer, Alexander J., additional, Mesquita, Ana Carolina F., additional, Miralhes, Patricia, additional, Mirtorabi, Neginsadat, additional, Mitton, Celia, additional, Mnyakeni, Sibusiso, additional, Moghaddas, Fiona, additional, Molapo, Kgaogelo, additional, Moloi, Mapule, additional, Moore, Maria, additional, Moran, Marni, additional, Morey, Ella, additional, Morgans, Róisín, additional, Morris, Susan J., additional, Morris, Sheila, additional, Morrison, Hazel, additional, Morselli, Franca, additional, Morshead, Gertraud, additional, Morter, Richard, additional, Mottay, Lynelle, additional, Moultrie, Andrew, additional, Moyo, Nathifa, additional, Mpelembue, Mushiya, additional, Msomi, Sibekezelo, additional, Mugodi, Yvonne, additional, Mukhopadhyay, Ekta, additional, Muller, Jilly, additional, Munro, Alasdair, additional, Murphy, Sarah, additional, Mweu, Philomena, additional, Myerscough, Christopher, additional, Naik, Gurudutt, additional, Naker, Kush, additional, Nastouli, Eleni, additional, Ndlovu, Bongani, additional, Nikolaou, Elissavet, additional, Njenga, Cecilia, additional, Noal, Helena C., additional, Noé, Andrés, additional, Novaes, Gabrielle, additional, Nugent, Fay L., additional, Nunes, Géssika Lanzillo A., additional, O'Brien, Katie, additional, O'Connor, Daniel, additional, Oelofse, Suzette, additional, Oguti, Blanche, additional, Olchawski, Victoria, additional, Oldfield, Neil J., additional, Oliveira, Marianne G., additional, Oliveira, Catarina, additional, Oliveira, Isabelle Silva Queiroz, additional, Oommen-Jose, Aylin, additional, Oosthuizen, Angela, additional, O'Reilly, Paula, additional, O'Reilly, Peter J., additional, Osborne, Piper, additional, Owen, David R.J., additional, Owen, Lydia, additional, Owens, Daniel, additional, Owino, Nelly, additional, Pacurar, Mihaela, additional, Paiva, Brenda V.B., additional, Palhares, Edna M.F., additional, Palmer, Susan, additional, Parracho, Helena M. R.T., additional, Parsons, Karen, additional, Patel, Dipak, additional, Patel, Bhumika, additional, Patel, Faeezah, additional, Patrick-Smith, Maia, additional, Payne, Ruth O., additional, Peng, Yanchun, additional, Penn, Elizabeth J., additional, Pennington, Anna, additional, Peralta Alvarez, Marco Polo, additional, Pereira Stuchi, Bruno Pereira, additional, Perez, Ana Luiza, additional, Perinpanathan, Tanaraj, additional, Perring, James, additional, Perumal, Rubeshan, additional, Petkar, Sahir Yusuf, additional, Philip, Tricia, additional, Phillips, Jennifer, additional, Phohu, Mary Kgomotso, additional, Pickup, Lorinda, additional, Pieterse, Sonja, additional, Pinheiro, Jessica Morgana, additional, Piper, Jo, additional, Pipini, Dimitra, additional, Plank, Mary, additional, Plant, Sinéad, additional, Pollard, Samuel, additional, Pooley, Jennifer, additional, Pooran, Anil, additional, Poulton, Ian, additional, Powers, Claire, additional, Presa, Fernando B., additional, Price, David A., additional, Price, Vivien, additional, Primeira, Marcelo R., additional, Proud, Pamela C., additional, Provstgaard-Morys, Samuel, additional, Pueschel, Sophie, additional, Pulido, David, additional, Quaid, Sheena, additional, Rabara, Ria, additional, Radia, Kajal, additional, Rajapaska, Durga, additional, Rajeswaran, Thurkka, additional, Ramos, Leonardo, additional, Ramos, Alberto San Francisco, additional, Ramos Lopez, Fernando, additional, Rampling, Tommy, additional, Rand, Jade, additional, Ratcliffe, Helen, additional, Rawlinson, Tom, additional, Rea, David, additional, Rees, Byron, additional, Resuello-Dauti, Mila, additional, Reyes Pabon, Emilia, additional, Rhead, Sarah, additional, Riaz, Tawassal, additional, Ricamara, Marivic, additional, Richards, Alexander, additional, Richter, Alex, additional, Ritchie, Neil, additional, Ritchie, Adam J., additional, Robbins, Alexander J., additional, Roberts, Hannah, additional, Robinson, Ryan E., additional, Roche, Sophie, additional, Rollier, Christine, additional, Rose, Louisa, additional, Ross Russell, Amy L., additional, Rossouw, Lindie, additional, Royal, Simon, additional, Rudiansyah, Indra, additional, Ryalls, Kim, additional, Sabine, Charlotte, additional, Saich, Stephen, additional, Sale, Jessica C., additional, Salman, Ahmed M., additional, Salvador, Natalia, additional, Salvador, Stephannie, additional, Sampaio, Milla Dias, additional, Samson, Annette D., additional, Sanchez-Gonzalez, Amada, additional, Sanders, Helen, additional, Sanders, Katherine, additional, Santos, Erika, additional, Santos Guerra, Mayara F.S., additional, Satti, Iman, additional, Saunders, Jack E., additional, Saunders, Caroline, additional, Sayed, Aakifah Bibi Arif, additional, Schim van der Loeff, Ina, additional, Schmid, Annina B., additional, Schofield, Ella, additional, Screaton, Gavin R., additional, Seddiqi, Samiullah, additional, Segireddy, Rameswara R., additional, Senger, Roberta, additional, Serrano, Sonia, additional, Shaik, Imam, additional, Sharpe, Hannah R., additional, Sharrocks, Katherine, additional, Shaw, Robert, additional, Shea, Adam, additional, Sheehan, Emma, additional, Shepherd, Amy, additional, Shiham, Farah, additional, Silk, Sarah E., additional, Silva-Reyes, Laura, additional, Silveira, Lidiana B. T.D., additional, Silveira, Mariana B.V., additional, Singh, Nisha, additional, Sinha, Jaisi, additional, Skelly, Donal T., additional, Smith, Daniel C., additional, Smith, Nick, additional, Smith, Holly E., additional, Smith, David J., additional, Smith, Catherine C., additional, Soares, Airanuédida S., additional, Solórzano, Carla, additional, Sorio, Guilherme L., additional, Sorley, Kim, additional, Sosa-Rodriguez, Tiffany, additional, Souza, Cinthia M.C.D.L., additional, Souza, Bruno S.D.F., additional, Souza, Alessandra R., additional, Souza Lopez, Thamyres, additional, Sowole, Luciana, additional, Spencer, Alexandra J., additional, Spoors, Louise, additional, Stafford, Lizzie, additional, Stamford, Imogen, additional, Stein, Ricardo, additional, Stockdale, Lisa, additional, Stockwell, Lisa V., additional, Strickland, Louise H., additional, Stuart, Arabella, additional, Sturdy, Ann, additional, Sutton, Natalina, additional, Szigeti, Anna, additional, Tahiri-Alaoui, Abdessamad, additional, Tanner, Rachel, additional, Taoushanis, Carol, additional, Tarr, Alexander W., additional, Tarrant, Richard, additional, Taylor, Keja, additional, Taylor, Ursula, additional, Taylor, Iona Jennifer, additional, Taylor, Justin, additional, te Water Naude, Rebecca, additional, Templeton, Kate, additional, Themistocleous, Yrene, additional, Themistocleous, Andreas, additional, Thomas, Merin, additional, Thomas, Kelly, additional, Thomas, Tonia M., additional, Thombrayil, Asha, additional, Thompson, Julia, additional, Thompson, Fawziyah, additional, Thompson, Ameeka, additional, Thompson, Amber, additional, Thompson, Kevin, additional, Thornton-Jones, Viv, additional, Thotusi, Larissa H.S., additional, Tighe, Patrick J., additional, Tinoco, Lygia Accioly, additional, Tiongson, Gerlynn Ferreras, additional, Tladinyane, Bonolo, additional, Tomasicchio, Michele, additional, Tomic, Adriana, additional, Tonks, Susan, additional, Towner, James, additional, Tran, Nguyen, additional, Tree, Julia A., additional, Trillana, Gerry, additional, Trinham, Charlotte, additional, Trivett, Rose, additional, Truby, Adam, additional, Tsheko, Betty Lebogang, additional, Tubb, Philippa, additional, Turabi, Aadil, additional, Turner, Richard, additional, Turner, Cheryl, additional, Turner, Nicola, additional, Tyagi, Bhavya, additional, Ulaszewska, Marta, additional, Underwood, Benjamin R., additional, van Eck, Samual, additional, Varughese, Rachel, additional, Verbart, Dennis, additional, Verheul, Marije K., additional, Vichos, Iason, additional, Vieira, Taiane A., additional, Walker, Gemma, additional, Walker, Laura, additional, Wand, Matthew E., additional, Wardell, Theresa, additional, Warimwe, George M., additional, Warren, Sarah C., additional, Watkins, Bridget, additional, Watson, Marion E.E., additional, Watson, Ekaterina, additional, Webb, Stewart, additional, Webster, Angela, additional, Welch, Jessica, additional, Wellbelove, Zoe, additional, Wells, Jeanette H., additional, West, Alison J., additional, White, Beth, additional, White, Caroline, additional, White, Rachel, additional, Williams, Paul, additional, Williams, Rachel L., additional, Willingham, Silvia, additional, Winslow, Rebecca, additional, Woods, Danielle, additional, Woodyer, Mark, additional, Worth, Andrew T., additional, Wright, Danny, additional, Wroblewska, Marzena, additional, Yao, Andy, additional, Yim, Yee Ting Nicole, additional, Zambrano, Marina Bauer, additional, Zimmer, Rafael Leal, additional, Zizi, Dalila, additional, and Zuidewind, Peter, additional
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- 2021
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49. High Efficacy of a Low Dose Candidate Malaria Vaccine, R21 in 1 Adjuvant Matrix-M™, with Seasonal Administration to Children in Burkina Faso
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Datoo, Mehreen S., primary, Magloire Natama, Hamtandi, additional, Somé, Athanase, additional, Traoré, Ousmane, additional, Rouamba, Toussaint, additional, Bellamy, Duncan, additional, Yameogo, Prisca, additional, Valia, Daniel, additional, Tegneri, Moubarak, additional, Ouedraogo, Florence, additional, Soma, Rachidatou, additional, Sawadogo, Seydou, additional, Sorgho, Faizatou, additional, Derra, Karim, additional, Rouamba, Eli, additional, Orindi, Benedict, additional, Ramos-Lopez, Fernando, additional, Flaxman, Amy, additional, Cappuccini, Federica, additional, Kailath, Reshma, additional, Elias, Sean C., additional, Mukhopadhyay, Ekta, additional, Noe, Andres, additional, Cairns, Matthew, additional, Lawrie, Alison, additional, Roberts, Rachel, additional, Valéa, Innocent, additional, Sorgho, Hermann, additional, Williams, Nicola, additional, Glenn, Gregory, additional, Fries, Louis, additional, Reimer, Jenny, additional, Ewer, Katie J., additional, Shaligram, Umesh, additional, Hill, Adrian V. S., additional, and Tinto, Halidou, additional
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- 2021
- Full Text
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50. Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial
- Author
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Ramasamy, Maheshi N, primary, Minassian, Angela M, additional, Ewer, Katie J, additional, Flaxman, Amy L, additional, Folegatti, Pedro M, additional, Owens, Daniel R, additional, Voysey, Merryn, additional, Aley, Parvinder K, additional, Angus, Brian, additional, Babbage, Gavin, additional, Belij-Rammerstorfer, Sandra, additional, Berry, Lisa, additional, Bibi, Sagida, additional, Bittaye, Mustapha, additional, Cathie, Katrina, additional, Chappell, Harry, additional, Charlton, Sue, additional, Cicconi, Paola, additional, Clutterbuck, Elizabeth A, additional, Colin-Jones, Rachel, additional, Dold, Christina, additional, Emary, Katherine R W, additional, Fedosyuk, Sofiya, additional, Fuskova, Michelle, additional, Gbesemete, Diane, additional, Green, Catherine, additional, Hallis, Bassam, additional, Hou, Mimi M, additional, Jenkin, Daniel, additional, Joe, Carina C D, additional, Kelly, Elizabeth J, additional, Kerridge, Simon, additional, Lawrie, Alison M, additional, Lelliott, Alice, additional, Lwin, May N, additional, Makinson, Rebecca, additional, Marchevsky, Natalie G, additional, Mujadidi, Yama, additional, Munro, Alasdair P S, additional, Pacurar, Mihaela, additional, Plested, Emma, additional, Rand, Jade, additional, Rawlinson, Thomas, additional, Rhead, Sarah, additional, Robinson, Hannah, additional, Ritchie, Adam J, additional, Ross-Russell, Amy L, additional, Saich, Stephen, additional, Singh, Nisha, additional, Smith, Catherine C, additional, Snape, Matthew D, additional, Song, Rinn, additional, Tarrant, Richard, additional, Themistocleous, Yrene, additional, Thomas, Kelly M, additional, Villafana, Tonya L, additional, Warren, Sarah C, additional, Watson, Marion E E, additional, Douglas, Alexander D, additional, Hill, Adrian V S, additional, Lambe, Teresa, additional, Gilbert, Sarah C, additional, Faust, Saul N, additional, Pollard, Andrew J, additional, Aboagye, Jeremy, additional, Adams, Kelly, additional, Ali, Aabidah, additional, Allen, Elizabeth R., additional, Allen, Lauren, additional, Allison, Jennifer L., additional, Andritsou, Foteini, additional, Anslow, Rachel, additional, Arbe-Barnes, Edward H., additional, Baker, Megan, additional, Baker, Natalie, additional, Baker, Philip, additional, Baleanu, Ioana, additional, Barker, Debbie, additional, Barnes, Eleanor, additional, Barrett, Jordan R., additional, Barrett, Kelly, additional, Bates, Louise, additional, Batten, Alexander, additional, Beadon, Kirsten, additional, Beckley, Rebecca, additional, Bellamy, Duncan, additional, Berg, Adam, additional, Bermejo, Laura, additional, Berrie, Eleanor, additional, Beveridge, Amy, additional, Bewley, Kevin, additional, Bijker, Else M., additional, Birch, Geeta, additional, Blackwell, Luke, additional, Bletchly, Heather, additional, Blundell, Caitlin L., additional, Blundell, Susannah R., additional, Bolam, Emma, additional, Boland, Elena, additional, Bormans, Daan, additional, Borthwick, Nicola, additional, Boukas, Konstantinos, additional, Bower, Thomas, additional, Bowring, Francesca, additional, Boyd, Amy, additional, Brenner, Tanja, additional, Brown, Phillip, additional, Brown-O'Sullivan, Charlie, additional, Bruce, Scott, additional, Brunt, Emily, additional, Burbage, Jamie, additional, Burgoyne, Joshua, additional, Buttigieg, Karen R., additional, Byard, Nicholas, additional, Cabera Puig, Ingrid, additional, Camara, Susana, additional, Cao, Michelangelo, additional, Cappuccini, Federica, additional, Carr, Melanie, additional, Carroll, Miles W., additional, Cashen, Paul, additional, Cavey, Ana, additional, Chadwick, Jim, additional, Challis, Ruth, additional, Chapman, David, additional, Charles, David, additional, Chelysheva, Irina, additional, Cho, Jee-Sun, additional, Cifuentes, Liliana, additional, Clark, Elizabeth, additional, Collins, Sarah, additional, Conlon, Christopher P., additional, Coombes, Naomi S., additional, Cooper, Rachel, additional, Cooper, Cushla, additional, Crocker, Wendy E.M., additional, Crosbie, Sarah, additional, Cullen, Dan, additional, Cunningham, Christina, additional, Cuthbertson, Fiona, additional, Datoo, Brad E., additional, Dando, Lynne, additional, Datoo, Mehreen S., additional, Datta, Chandrabali, additional, Davies, Hannah, additional, Davies, Sarah, additional, Davis, Elizabeth J., additional, Davis, Judith, additional, Dearlove, David, additional, Demissie, Tesfaye, additional, Di Marco, Stefania, additional, Di Maso, Claudio, additional, DiTirro, Danielle, additional, Docksey, Claire, additional, Dong, Tao, additional, Donnellan, Francesca R., additional, Douglas, Naomi, additional, Downing, Charlotte, additional, Drake, Jonathan, additional, Drake-Brockman, Rachael, additional, Drury, Ruth E., additional, Dunachie, Susanna J., additional, Edwards, Christopher J., additional, Edwards, Nick J., additional, El Muhanna, Omar, additional, Elias, Sean C., additional, Elliott, Ryan S., additional, Elmore, Michael J., additional, English, Marcus Rex, additional, Felle, Sally, additional, Feng, Shuo, additional, Ferreira Da Silva, Carla, additional, Field, Samantha, additional, Fisher, Richard, additional, Fixmer, Carine, additional, Ford, Karen J., additional, Fowler, Jamie, additional, Francis, Emma, additional, Frater, John, additional, Furze, Julie, additional, Galian-Rubio, Pablo, additional, Galloway, Celine, additional, Garlant, Harriet, additional, Gavrila, Madita, additional, Gibbons, Felicity, additional, Gibbons, Karyna, additional, Gilbride, Ciaran, additional, Gill, Hardeep, additional, Godwin, Kerry, additional, Gordon-Quayle, Katherine, additional, Gorini, Giacomo, additional, Goulston, Lyndsey, additional, Grabau, Caroline, additional, Gracie, Lara, additional, Graham, Nichola, additional, Greenwood, Nicola, additional, Griffiths, Oliver, additional, Gupta, Gaurav, additional, Hamilton, Elizabeth, additional, Hanumunthadu, Brama, additional, Harris, Stephanie A., additional, Harris, Tara, additional, Harrison, Daisy, additional, Hart, Thomas C., additional, Hartnell, Birgit, additional, Haskell, Louise, additional, Hawkins, Sophia, additional, Henry, John Aaron, additional, Hermosin Herrera, Macarena, additional, Hill, David, additional, Hill, Jennifer, additional, Hodges, Gina, additional, Hodgson, Susanne H.C., additional, Horton, Katie L., additional, Howe, Elizabeth, additional, Howell, Nicola, additional, Howes, Jessica, additional, Huang, Ben, additional, Humphreys, Jonathan, additional, Humphries, Holly E., additional, Iveson, Poppy, additional, Jackson, Frederic, additional, Jackson, Susan, additional, Jauregui, Sam, additional, Jeffers, Helen, additional, Jones, Bryony, additional, Jones, Christine E., additional, Jones, Elizabeth, additional, Jones, Kathryn, additional, Joshi, Amar, additional, Kailath, Reshma, additional, Keen, Jade, additional, Kelly, Dearbhla M., additional, Kelly, Sarah, additional, Kelly, Debbie, additional, Kerr, David, additional, Khan, Liaquat, additional, Khozoee, Baktash, additional, Killen, Annabel, additional, Kinch, Jasmin, additional, King, Lloyd D.W., additional, King, Thomas B., additional, Kingham, Lucy, additional, Klenerman, Paul, additional, Knight, Julian C., additional, Knott, Daniel, additional, Koleva, Stanislava, additional, Lang, Gail, additional, Larkworthy, Colin W., additional, Larwood, Jessica P.J., additional, Law, Rebecca, additional, Lee, Arlene, additional, Lee, Kim Y.N., additional, Lees, Emily A., additional, Leung, Stephanie, additional, Li, Yuanyuan, additional, Lias, Amelia M., additional, Linder, Aline, additional, Lipworth, Samuel, additional, Liu, Shuchang, additional, Liu, Xinxue, additional, Lloyd, Stephanie, additional, Loew, Lisa, additional, Lopez Ramon, Raquel, additional, Madhavan, Meera, additional, Mainwaring, David O., additional, Mallett, Garry, additional, Mansatta, Kushal, additional, Marinou, Spyridoula, additional, Marius, Phedra, additional, Marlow, Emma, additional, Marriott, Paula, additional, Marshall, Julia L., additional, Martin, Jane, additional, Masters, Shauna, additional, McEwan, Joanne, additional, McGlashan, Joanna L., additional, McInroy, Lorna, additional, McRobert, Nicky, additional, Megson, Clare, additional, Mentzer, Alexander J., additional, Mirtorabi, Neginsadat, additional, Mitton, Celia, additional, Moore, Maria, additional, Moran, Marni, additional, Morey, Ella, additional, Morgans, Róisín, additional, Morris, Susan J., additional, Morrison, Hazel Morrison, additional, Morshead, Gertraud, additional, Morter, Richard, additional, Moya, Nathifa A., additional, Mukhopadhyay, Ekta, additional, Muller, Jilly, additional, Munro, Claire, additional, Murphy, Sarah, additional, Mweu, Philomena, additional, Noé, Andrés, additional, Nugent, Fay L., additional, O'Brien, Katie, additional, O'Connor, Daniel, additional, Oguti, Blanché, additional, Olchawski, Victoria, additional, Oliveira, Catarina, additional, O'Reilly, Peter John, additional, Osborne, Piper, additional, Owen, Lydia, additional, Owino, Nelly, additional, Papageorgiou, Panagiotis, additional, Parracho, Helena, additional, Parsons, Karen, additional, Patel, Bhumika, additional, Patrick-Smith, Maia, additional, Peng, Yanchun, additional, Penn, Elizabeth J., additional, Peralta-Alvarez, Marco Polo, additional, Perring, James, additional, Petropoulos, Christos, additional, Phillips, Daniel J., additional, Pipini, Dimitra, additional, Pollard, Samuel, additional, Poulton, Ian, additional, Pratt, Danny, additional, Presland, Laura, additional, Proud, Pamela C., additional, Provstgaard-Morys, Samuel, additional, Pueschel, Sophie, additional, Pulido, David, additional, Rabara, Ria, additional, Radia, Kajal, additional, Rajapaska, Durga, additional, Ramos Lopez, Fernando, additional, Ratcliffe, Helen, additional, Rayhan, Sara, additional, Rees, Byron, additional, Reyes Pabon, Emilia, additional, Roberts, Hannah, additional, Robertson, Isla, additional, Roche, Sophie, additional, Rollier, Christine S., additional, Romani, Rossana, additional, Rose, Zoe, additional, Rudiansyah, Indra, additional, Sabheha, Sabeha, additional, Salvador, Stephannie, additional, Sanders, Helen, additional, Sanders, Katherine, additional, Satti, Iman, additional, Sayce, Chloe, additional, Schmid, Annina B., additional, Schofield, Ella, additional, Screaton, Gavin, additional, Sedik, Cynthia, additional, Seddiqi, Samiullah, additional, Segireddy, Rameswara R., additional, Selby, Beatrice, additional, Shaik, Imam, additional, Sharpe, Hannah R., additional, Shaw, Robert, additional, Shea, Adam, additional, Silk, Sarah, additional, Silva-Reyes, Laura, additional, Skelly, Donal T., additional, Smith, David J., additional, Smith, Daniel C., additional, Smith, Nicholas, additional, Spencer, Alexandra J., additional, Spoors, Louise, additional, Stafford, Elizabeth, additional, Stamford, Imogen, additional, Stockdale, Lisa, additional, Stockley, David, additional, Stockwell, Lisa V., additional, Stokes, Matthew, additional, Strickland, Louise H., additional, Stuart, Arabella, additional, Sulaiman, Sulaiman, additional, Summerton, Eloise, additional, Swash, Zoe, additional, Szigeti, Anna, additional, Tahiri-Alaoui, Abdessamad, additional, Tanner, Rachel, additional, Taylor, Iona, additional, Taylor, Keja, additional, Taylor, Ursula, additional, te Water Naude, Rebecca, additional, Themistocleous, Andreas, additional, Thomas, Merin, additional, Thomas, Tonia M., additional, Thompson, Amber, additional, Thompson, Kevin, additional, Thornton-Jones, Viv, additional, Tinh, Lan, additional, Tomic, Adriana, additional, Tonks, Susan, additional, Towner, James, additional, Tran, Nguyen, additional, Tree, Julian A., additional, Truby, Adam, additional, Turner, Cheryl, additional, Turner, Richard, additional, Ulaszewska, Marta, additional, Varughese, Rachel, additional, Verbart, Dennis, additional, Verheul, Marije K., additional, Vichos, Iason, additional, Walker, Laura, additional, Wand, Matthew E., additional, Watkins, Bridget, additional, Welch, Jessica, additional, West, Alison J., additional, White, Caroline, additional, White, Rachel, additional, Williams, Paul, additional, Woodyer, Mark, additional, Worth, Andrew T., additional, Wright, Daniel, additional, Wrin, Terri, additional, Yao, Xin Li, additional, Zbarcea, Diana-Andreea, additional, and Zizi, Dalila, additional
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