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The crown of a successful academic career is often considered an achievement of tenure. The path to tenure may vary based on the type of Carnegie University at which one is employed. Carnegie Doctoral granting R1 Universities place a high priority on conducting research, grant writing and publishing while other Carnegie classified Universities place more emphasis on teaching. Regardless of a University's Carnegie classification the path to tenure requires sound time management skills if an academic is to achieve tenure. To that end, the authors have decided to revisit Covey's Time Management Matrix (CTMM). The authors provide an ethnographic perspective with respect to the Quadrants of the CTMM for the purpose of providing a priority driven time self-management instrument to assist academics navigating towards tenure. Priority driven effective time self-management is key to successfully achieving tenure and we forward our academic interpretation of the CTMM as a potential guide for academics and their administrators. Further, the authors suggest that a priority driven effective time self-management strategy is portable across disciplines and national/cultural borders.

No study has assessed supramaximal (over 100% 1RM) back squat variations as a potentiating stimulus in collegiate throwers. The purpose of this study was to test the hypothesis that a supramaximal Anderson (bottom-up) quarter squat potentiating stimulus would improve discus throw performance in Division I throwers compared to a dynamic warm-up alone. Nine NCAA division I thrower athletes (age: 20.1±1.4 years; 1RM back squat/body weight: 2.5±0.4 kg) randomly completed two sessions separated by at least 72 hours. One session involved a standardized dynamic warm-up alone (DyWU) followed by three trials of maximal discus throwing. The other session involved a dynamic warm-up with a supramaximal (105% 1RM) Anderson (bottom-up) quarter-squat set of 5 repetitions post activation performance enhancement stimulus (DyWU+PAPE) followed by three trials of maximal discus throwing. A two-way (warm-up strategy x time) ANOVA with repeated measures for each time point was used, with significance set at p< 0.05. There were no significant (p> 0.05) differences between DyWU alone versus DyWU+PAPE stimulus for discus throw distances at either 8 min. (31.7±5.6 vs 30.6±6.5 meters, respectively; d = -0.18), 11 min. (33.4±3.6 vs 31.3±4.7 meters, respectively; d = -0.52), or 14 min. post warm-up (34.1±3.9 vs 32.3±5.3 meters, respectively; d = -0.40). Compared to a dynamic warm-up alone, supramaximal Anderson quarter-squats following a dynamic warm-up had trivial/small to moderate detrimental effects on discus throw performance between 8-14 minutes post stimuli in Division I trained throwers, likely due to excess fatigue/PAPE inhibition. [ABSTRACT FROM AUTHOR]

This study examined the impact extreme volume-load differences for a single weekly exercise, when all other exercises' volume loads were similar, would have on American football performance variables after inseason resistance training (RT). Twenty male National Collegiate Athletic Association (NCAA) American footballers (18-23 years, 98.4 6 19.3 kg) were randomly assigned to an extreme high-volume low-intensity (EHVLI; n 5 11) group or a low-volume highintensity (LVHI; n 5 9) group. Subjects performed the same evidence-based RT exercises and volume loads for 8 weeks thrice weekly, with the only differences being once weekly unilateral reverse dumbbell lunge (EHVLI) or unilateral Hatfield safety bar back squat (LVHI) exercises performed with different volume loads. Performance variables were assessed 1 week before (PRE) and after (POST) 8 weeks of RT. A 2-way analysis of variance with repeated measures and the Sidak post hoc test were used (p, 0.05). Extreme high-volume low-intensity had no significant (p. 0.05) PRE-to-POST RT changes in muscular strength in 1 repetition maximum (251.8 6 48.7 to 274.6 6 61.3 kg) or power in vertical jump (79.2 6 8.8 to 78.2 6 10.8 cm). Conversely, LVHI had significant (p=0.05) PRE-to-POST RT improvements in strength (249.2654.4 to 284.1655.0 kg) and power (72.8611.4 to 76.3 6 10.0 cm). Furthermore, LVHI vs. EHVLI displayed significantly greater percentage difference increases from PRE values in muscular power (6.7% 6 7.2 vs. 21.3% 6 6.0, respectively), with no significant differences between groups (LVHI vs. EHVLI) in muscular strength (8.8% 6 3.1 vs. 6.7% 6 8.0, respectively) and 10-yard acceleration (2.2% 6 5.6 vs. 3.2% 6 5.6, respectively). For in-season RT of strength and power in collegiate American football players, all exercises performed should use evidence-based volume loads to optimize adaptations because a single exercise performed with extreme volume load may limit muscular strength and power development. [ABSTRACT FROM AUTHOR]

Maximal isometric handgrip strength (HGS) is used as an indicator of overall muscular strength and has also been found to be predictive of certain athletic events sporting prowess. Women’s artistic gymnastics requires athletes have high levels of relative muscular strength and power to be successful. This study examined the relationship between HGS and gymnastics performance scores for the 4 events of vault, uneven bars, beam, and floor in female collegiate artistic gymnasts. Twenty-five (n=25) female National Collegiate Athletic Association (NCAA) Division I North American collegiate women’s artistic gymnasts (age: 20.1±1.3 yrs; height: 158.9±5.6 cm; mass: 58.2±5.3 kg) were assessed for a one-time measurement of absolute HGS in kg and relative HGS (HGS/height in m2), as well as their average vault, uneven bars, beam, and floor performance scores across a competitive season. Pearson correlation coefficients (r) were determined between HGS and all performance scores. No significant (p > 0.05) correlations were found between absolute HGS (30.8±4.4 kg) or relative HGS (12.0±1.6 kg/m2) and any 4 gymnastics event’s performance scores (r range: -0.07 – 0.50 or r range: -0.06 – 0.31, respectively). In this female collegiate gymnastics’ population, 56% had an absolute HGS and 80% had a relative HGS, respectively, above the 50th percentile of all similarly aged adult females in the United States. In the current population of female collegiate gymnasts, absolute and relative HGS were not related to any gymnastics events performance scores and adds to the existing literature, supporting no relationships between HGS and sports performances where sports movements require a high degree of technical precision and accuracy. Findings from this investigation can be used by athletes, coaches, and practitioners in the collegiate women’s gymnastics realm to assess if athletes have attained sufficient absolute HGS, and especially relative HGS values, to be successful. [ABSTRACT FROM AUTHOR]

Background: Translational capacity (i.e. ribosomal mass) is a key determinant of protein synthesis and has been associated with skeletal muscle hypertrophy. The role of translational capacity in muscle atrophy and regrowth from disuse is largely unknown. Therefore, we investigated the effect of muscle disuse and reloading on translational capacity in middle‐aged men (Study 1) and in rats (Study 2). Methods: In Study 1, 28 male participants (age 50.03 ± 3.54 years) underwent 2 weeks of knee immobilization followed by 2 weeks of ambulatory recovery and a further 2 weeks of resistance training. Muscle biopsies were obtained for measurement of total RNA and pre‐ribosomal (r)RNA expression, and vastus lateralis cross‐sectional area (CSA) was determined via peripheral quantitative computed tomography. In Study 2, male rats underwent hindlimb suspension (HS) for either 24 h (HS 24 h, n = 4) or 7 days (HS 7d, n = 5), HS for 7 days followed by 7 days of reloading (Rel, n = 5) or remained as ambulatory weight bearing (WB, n = 5) controls. Rats received deuterium oxide throughout the study to determine RNA synthesis and degradation, and mTORC1 signalling pathway was assessed. Results: Two weeks of immobilization reduced total RNA concentration (20%) and CSA (4%) in men (both P ≤ 0.05). Ambulatory recovery restored total RNA concentration to baseline levels and partially restored muscle CSA. Total RNA concentration and 47S pre‐rRNA expression increased above basal levels after resistance training (P ≤ 0.05). In rats, RNA synthesis was 30% lower while degradation was ~400% higher in HS 7d in soleus and plantaris muscles compared with WB (P ≤ 0.05). mTORC1 signalling was lower in HS compared with WB as was 47S pre‐rRNA (P ≤ 0.05). With reloading, the aforementioned parameters were restored to WB levels while RNA degradation was suppressed (P ≤ 0.05). Conclusions: Changes in RNA concentration following muscle disuse and reloading were associated with changes in ribosome biogenesis and degradation, indicating that both processes are important determinants of translational capacity. The pre‐clinical data help explain the reduced translational capacity after muscle immobilization in humans and demonstrate that ribosome biogenesis and degradation might be valuable therapeutic targets to maintain muscle mass during disuse. [ABSTRACT FROM AUTHOR]

The purpose of this study was to determine: 1) the extent to which an acute session of high-intensity interval training (HIIT) increases systemic inflammatory cytokines and chemokines, and 2) whether 2 weeks of HIIT training alters the inflammatory response. Eight recreationally active males (aged 22±2 years) performed 2 weeks of HIIT on a cycle ergometer (six HIIT sessions at 8-12 intervals; 60-second intervals, 75-second active rest) at a power output equivalent to 100% of their predetermined peak oxygen uptake (VO2max). Serum samples were collected during the first and sixth HIIT sessions at rest and immediately, 15, 30, and 45 minutes post-exercise. An acute session of HIIT induced significant increases in interleukin (IL)-6, IL-8, IL-10, tumor necrosis factor-α, and monocyte chemotactic protein-1 compared with rest. The concentrations of interferon-γ, granulocyte macrophage-colony-stimulating factor, and IL-1β were unaltered with an acute session of HIIT. Two weeks of training did not alter the inflammatory response to an acute bout of HIIT exercise. Maximal power achieved during a VO2max test significantly increased 4.6%, despite no improvements in VO2max after 2 weeks of HIIT. These data suggest that HIIT exercise induces a small inflammatory response in young, recreationally active men; however, 2 weeks of HIIT does not alter this response. [ABSTRACT FROM AUTHOR]

This study examined using a traditional Olympic (OL) or safety squat bar (SSB) barbell on force, velocity, and perceived exertion during an acute session of high-intensity back squats in adults. Twelve recreationally trained men (23.0±2.6 years; 88.3±19.1 kg) randomly completed two sessions of 3 sets of 6 repetitions at the same absolute load using the OL barbell or SSB barbell. Force and velocity were measured on every repetition and rating of perceived exertion (RPE) was assessed for each set. A two-way ANOVA (set x barbell) with repeated measures and Sidak post-hoc test (repetitions set-by-set) or paired t-test (repetitions independent of set) were used (p<0.05). Compared to a traditional OL barbell, using a SSB barbell resulted in no significant differences in peak force (2443.0±46.6 vs 2622.9±65.8 N, respectively; d =0.28) or average set RPE (7.8±0.8 vs 8.0±1.2, respectively; d =0.15) during an acute multi-set high-intensity back squat session. In contrast, compared to a traditional OL barbell, using a SSB barbell resulted in significantly (p<0.05) lower average velocity (0.42±0.04 vs 0.38±0.05 m/s, respectively; d =0.27) during the same parameters. When performing the back squat exercise recreationally resistance-trained adults exhibit similar peak force and perceived effort with OL or SSB barbells, but greater velocities can be achieved with the OL barbell. Practitioners working with adults to develop lower body strength and power with the back squat exercise across multiple sets can interchangeably use the OL or SSB barbells to similarly train force, but training velocity is trivially better with the OL barbell acutely.

Cancer survivors are more susceptible to pathologies such as hypertension, liver disease, depression, and coronary artery disease when compared with individuals who have never been diagnosed with cancer. Therefore, it is important to understand how tumor burden negatively impacts nontumor-bearing tissues that may impact future disease susceptibility. We hypothesized that the energetic costs of a tumor would compromise proteostatic maintenance in other tissues. Therefore, the purpose of this study was to determine if tumor burden changes protein synthesis and proliferation rates in heart, brain, and liver. One million Lewis lung carcinoma (LLC) cells or phosphate-buffered saline (PBS, sham) were injected into the hind flank of female mice at ∼4.5 mo of age, and the tumor developed for 3 wk. Rates of proliferation and protein synthesis were measured in heart, brain, liver, and tumor tissue. Compared with sham, rates of protein synthesis (structural/nuclear, cytosolic, mitochondrial, and collagen) relative to proliferation were lower in the heart and liver of LLC mice, but higher in the brain of LLC mice. In the tumor tissue, the ratio of protein synthesis to DNA synthesis was approximately 1.0 showing that protein synthesis in the tumor was used for proliferation with little proteostatic maintenance. We further provide evidence that the differences in tissue responses may be due to energetic stress. We concluded that the decrease in proteostatic maintenance in liver, heart, and muscle might contribute to the increased risk of disease in cancer survivors. NEW & NOTEWORTHY We present data showing that simultaneously measuring protein synthesis and cell proliferation can help in the understanding of protein turnover as a proteostatic process in response to tumor burden. In some tissues, like hepatic, cardiac, and skeletal muscle, there was a decrease in the protein to DNA synthesis ratio indicating less proteostatic maintenance. In contrast, the brain maintained or even increased this protein to DNA synthesis ratio indicating more proteostatic maintenance.

Small noncoding microRNAs (miRNAs) are important regulators of skeletal muscle size, and circulating miRNAs within extracellular vesicles (EVs) may contribute to atrophy and its associated systemic effects. The purpose of this study was to understand how muscle atrophy and regrowth alter in vivo serum EV miRNA content. We also associated changes in serum EV miRNA with protein synthesis, protein degradation, and miRNA within muscle, kidney, and liver. We subjected adult (10 mo) F344/BN rats to three conditions: weight bearing (WB), hindlimb suspension (HS) for 7 days to induce muscle atrophy, and HS for 7 days followed by 7 days of reloading (HSR). Microarray analysis of EV miRNA content showed that the overall changes in serum EV miRNA were predicted to target major anabolic, catabolic, and mechanosensitive pathways. MiR-203a-3p was the only miRNA demonstrating substantial differences in HS EVs compared with WB. There was a limited association of EV miRNA content to the corresponding miRNA content within the muscle, kidney, or liver. Stepwise linear regression demonstrated that EV miR-203a-3p was correlated with muscle mass and muscle protein synthesis and degradation across all conditions. Finally, EV miR-203a-3p expression was significantly decreased in human subjects who underwent unilateral lower limb suspension (ULLS) to induce muscle atrophy. Altogether, we show that serum EV miR-203a-3p expression is related to skeletal muscle protein turnover and atrophy. We suggest that serum EV miR-203a-3p content may be a useful biomarker and future work should investigate whether serum EV miR-203a-3p content is mechanistically linked to protein synthesis and degradation.