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Monte-Carlo (MC) Dropout provides a practical solution for estimating predictive distributions in deterministic neural networks. Traditional dropout, applied within the signal space, may fail to account for frequency-related noise common in medical imaging, leading to biased predictive estimates. A novel approach extends Dropout to the frequency domain, allowing stochastic attenuation of signal frequencies during inference. This creates diverse global textural variations in feature maps while preserving structural integrity -- a factor we hypothesize and empirically show is contributing to accurately estimating uncertainties in semantic segmentation. We evaluated traditional MC-Dropout and the MC-frequency Dropout in three segmentation tasks involving different imaging modalities: (i) prostate zones in biparametric MRI, (ii) liver tumors in contrast-enhanced CT, and (iii) lungs in chest X-ray scans. Our results show that MC-Frequency Dropout improves calibration, convergence, and semantic uncertainty, thereby improving prediction scrutiny, boundary delineation, and has the potential to enhance medical decision-making., Comment: Accepted by IEEE ISBI 2025 4-page paper. Code for the implementation is available at https://github.com/talze/frequency-dropout

Accurate uncertainty estimation is crucial for deploying neural networks in risk-sensitive applications such as medical diagnosis. Monte Carlo Dropout is a widely used technique for approximating predictive uncertainty by performing stochastic forward passes with dropout during inference. However, using static dropout rates across all layers and inputs can lead to suboptimal uncertainty estimates, as it fails to adapt to the varying characteristics of individual inputs and network layers. Existing approaches optimize dropout rates during training using labeled data, resulting in fixed inference-time parameters that cannot adjust to new data distributions, compromising uncertainty estimates in Monte Carlo simulations. In this paper, we propose Rate-In, an algorithm that dynamically adjusts dropout rates during inference by quantifying the information loss induced by dropout in each layer's feature maps. By treating dropout as controlled noise injection and leveraging information-theoretic principles, Rate-In adapts dropout rates per layer and per input instance without requiring ground truth labels. By quantifying the functional information loss in feature maps, we adaptively tune dropout rates to maintain perceptual quality across diverse medical imaging tasks and architectural configurations. Our extensive empirical study on synthetic data and real-world medical imaging tasks demonstrates that Rate-In improves calibration and sharpens uncertainty estimates compared to fixed or heuristic dropout rates without compromising predictive performance. Rate-In offers a practical, unsupervised, inference-time approach to optimizing dropout for more reliable predictive uncertainty estimation in critical applications., Comment: Updated author affiliation

How do people use their faces and bodies to test the interactive abilities of a robot? Making lively, believable agents is often seen as a goal for robots and virtual agents but believability can easily break down. In this Wizard-of-Oz (WoZ) study, we observed 1169 nonverbal interactions between 20 participants and 6 types of agents. We collected the nonverbal behaviors participants used to challenge the characters physically, emotionally, and socially. The participants interacted freely with humanoid and non-humanoid forms: a robot, a human, a penguin, a pufferfish, a banana, and a toilet. We present a human behavior codebook of 188 unique nonverbal behaviors used by humans to test the virtual characters. The insights and design strategies drawn from video observations aim to help build more interaction-aware and believable robots, especially when humans push them to their limits., Comment: 8 pages, 4 figures, Accepted to International Conference on Intelligent Robots and Systems (IROS 2024), project website: https://rosielab.github.io/react-to-this/

Task-based fMRI uses actions or stimuli to trigger task-specific brain responses and measures them using BOLD contrast. Despite the significant task-induced spatiotemporal brain activation fluctuations, most studies on task-based fMRI ignore the task context information aligned with fMRI and consider task-based fMRI a coherent sequence. In this paper, we show that using the task structures as data-driven guidance is effective for spatiotemporal analysis. We propose STNAGNN, a GNN-based spatiotemporal architecture, and validate its performance in an autism classification task. The trained model is also interpreted for identifying autism-related spatiotemporal brain biomarkers.

Following the Pluto fly-by of the New Horizons spacecraft, the mission provided a unique opportunity to explore the Kuiper Belt in-situ. The possibility existed to fly-by a Kuiper Belt object (KBO) as well as to observe additional objects at distances closer than are feasible from earth-orbit facilities. However, at the time of launch no KBOs were known about that were accessible by the spacecraft. In this paper we present the results of 10 years of observations and three uniquely dedicated efforts -- two ground-based using the Subaru Suprime Camera, the Magellan MegaCam and IMACS Cameras, and one with the Hubble Space Telescope -- to find such KBOs for study. In this paper we overview the search criteria and strategies employed in our work and detail the analysis efforts to locate and track faint objects in the galactic plane. We also present a summary of all of the KBOs that were discovered as part of our efforts and how spacecraft targetability was assessed, including a detailed description of our astrometric analysis which included development of an extensive secondary calibration network. Overall, these efforts resulted in the discovery of 89 KBOs including 11 which became objects for distant observation by New Horizons and (486958) Arrokoth which became the first post-Pluto fly-by destination., Comment: Accepted to PSJ. 40 pages, 10 figures, 10 tables

Smartphones are integral to modern life, yet research highlights the cognitive drawbacks associated even with their mere presence. Physically removing them from sight is a solution, but it is sometimes impractical and may increase anxiety due to fear of missing out. In response, we introduce a simple but effective use of augmented reality (AR) head-mounted displays, focusing not on augmenting reality with virtual objects, but on diminishing reality by selectively removing or occluding distracting objects, from the user's field of view. We compared cognitive task performance across four conditions: the smartphone being physically nearby, physically remote, visually removed and visually occluded via AR. Our findings reveal that using AR to visually cancel out smartphones significantly mitigates cognitive distractions caused by their presence. Specifically, the AR interventions had effects similar to physically removing the phone. These results suggest potential for novel AR applications designed to diminish reality, thereby enhancing cognitive performance.

Inter-frame motion in dynamic cardiac positron emission tomography (PET) using rubidium-82 (82-Rb) myocardial perfusion imaging impacts myocardial blood flow (MBF) quantification and the diagnosis accuracy of coronary artery diseases. However, the high cross-frame distribution variation due to rapid tracer kinetics poses a considerable challenge for inter-frame motion correction, especially for early frames where intensity-based image registration techniques often fail. To address this issue, we propose a novel method called Temporally and Anatomically Informed Generative Adversarial Network (TAI-GAN) that utilizes an all-to-one mapping to convert early frames into those with tracer distribution similar to the last reference frame. The TAI-GAN consists of a feature-wise linear modulation layer that encodes channel-wise parameters generated from temporal information and rough cardiac segmentation masks with local shifts that serve as anatomical information. Our proposed method was evaluated on a clinical 82-Rb PET dataset, and the results show that our TAI-GAN can produce converted early frames with high image quality, comparable to the real reference frames. After TAI-GAN conversion, the motion estimation accuracy and subsequent myocardial blood flow (MBF) quantification with both conventional and deep learning-based motion correction methods were improved compared to using the original frames., Comment: Under revision at Medical Image Analysis

This paper introduces a novel automated system for generating architecture schematic designs aimed at streamlining complex decision-making at the multifamily real estate development project's outset. Leveraging the combined strengths of generative AI (neuro reasoning) and mathematical program solvers (symbolic reasoning), the method addresses both the reliance on expert insights and technical challenges in architectural schematic design. To address the large-scale and interconnected nature of design decisions needed for designing a whole building, we proposed a novel sequential neuro-symbolic reasoning approach, emulating traditional architecture design processes from initial concept to detailed layout. To remove the need to hand-craft a cost function to approximate the desired objectives, we propose a solution that uses neuro reasoning to generate constraints and cost functions that the symbolic solvers can use to solve. We also incorporate feedback loops for each design stage to ensure a tight integration between neuro and symbolic reasoning. Developed using GPT-4 without further training, our method's effectiveness is validated through comparative studies with real-world buildings. Our method can generate various building designs in accordance with the understanding of the neighborhood, showcasing its potential to transform the realm of architectural schematic design.

Three-dimensional (3D) freehand ultrasound (US) is a widely used imaging modality that allows non-invasive imaging of medical anatomy without radiation exposure. Surface reconstruction of US volume is vital to acquire the accurate anatomical structures needed for modeling, registration, and visualization. However, traditional methods cannot produce a high-quality surface due to image noise. Despite improvements in smoothness, continuity, and resolution from deep learning approaches, research on surface reconstruction in freehand 3D US is still limited. This study introduces FUNSR, a self-supervised neural implicit surface reconstruction method to learn signed distance functions (SDFs) from US volumes. In particular, FUNSR iteratively learns the SDFs by moving the 3D queries sampled around volumetric point clouds to approximate the surface, guided by two novel geometric constraints: sign consistency constraint and onsurface constraint with adversarial learning. Our approach has been thoroughly evaluated across four datasets to demonstrate its adaptability to various anatomical structures, including a hip phantom dataset, two vascular datasets and one publicly available prostate dataset. We also show that smooth and continuous representations greatly enhance the visual appearance of US data. Furthermore, we highlight the potential of our method to improve segmentation performance, and its robustness to noise distribution and motion perturbation., Comment: Preprint

Deep learning methods for unsupervised registration often rely on objectives that assume a uniform noise level across the spatial domain (e.g. mean-squared error loss), but noise distributions are often heteroscedastic and input-dependent in real-world medical images. Thus, this assumption often leads to degradation in registration performance, mainly due to the undesired influence of noise-induced outliers. To mitigate this, we propose a framework for heteroscedastic image uncertainty estimation that can adaptively reduce the influence of regions with high uncertainty during unsupervised registration. The framework consists of a collaborative training strategy for the displacement and variance estimators, and a novel image fidelity weighting scheme utilizing signal-to-noise ratios. Our approach prevents the model from being driven away by spurious gradients caused by the simplified homoscedastic assumption, leading to more accurate displacement estimation. To illustrate its versatility and effectiveness, we tested our framework on two representative registration architectures across three medical image datasets. Our method consistently outperforms baselines and produces sensible uncertainty estimates. The code is publicly available at \url{https://voldemort108x.github.io/hetero_uncertainty/}., Comment: MICCAI 2024 camera-ready version

Insufficiency of training data is a persistent issue in medical image analysis, especially for task-based functional magnetic resonance images (fMRI) with spatio-temporal imaging data acquired using specific cognitive tasks. In this paper, we propose an approach for generating synthetic fMRI sequences that can then be used to create augmented training datasets in downstream learning tasks. To synthesize high-resolution task-specific fMRI, we adapt the $\alpha$-GAN structure, leveraging advantages of both GAN and variational autoencoder models, and propose different alternatives in aggregating temporal information. The synthetic images are evaluated from multiple perspectives including visualizations and an autism spectrum disorder (ASD) classification task. The results show that the synthetic task-based fMRI can provide effective data augmentation in learning the ASD classification task., Comment: Accepted by Machine Learning in Clinical Neuroimaging 2023 (MICCAI workshop), preprint version