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1. Comparison of infection and complication rates associated with transvenous vs. subcutaneous defibrillators in patients with stage 4 chronic kidney disease: a multicenter long-term retrospective follow-up

Author

Schiedat, Fabian, primary, Meuterodt, Benjamin, additional, Prull, Magnus, additional, Aweimer, Assem, additional, Gotzmann, Michael, additional, O’Connor, Stephen, additional, Perings, Christian, additional, Korth, Johannes, additional, Lawo, Thomas, additional, El-Battrawy, Ibrahim, additional, Hanefeld, Christoph, additional, Mügge, Andreas, additional, and Kloppe, Axel, additional

Published
2024
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2. Subcutaneous versus Transvenous Implantable Cardioverter Defibrillator in Patients with End-Stage Renal Disease Requiring Dialysis: Extended Long-Term Retrospective Multicenter Follow-Up.

Author

Schiedat, Fabian, Meuterodt, Benjamin, Winter, Joachim, Prull, Magnus, Aweimer, Assem, Gotzmann, Michael, O'Connor, Stephen, Perings, Christian, Lawo, Thomas, El-Battrawy, Ibrahim, Hanefeld, Christoph, Korth, Johannes, Mügge, Andreas, and Kloppe, Axel

Subjects
CHRONIC kidney failure, CARDIAC arrest, GENERAL practitioners, HEMODIALYSIS patients, ARTIFICIAL implants, IMPLANTABLE cardioverter-defibrillators
Abstract

Background: Implantable cardioverter defibrillators (ICD) prevent sudden cardiac death (SCD). Patients with end-stage renal disease (ESRD) requiring dialysis are at a very high risk of infection from cardiac implantable electronic device (CIED) implantation as well as mortality. In the present study, we compared the long-term complications and outcomes between subcutaneous ICD (S-ICD) and transvenous ICD (TV-ICD) recipients. Methods: In this retrospective analysis, we analyzed a total of 43 patients with ESRD requiring dialysis who received either a prophylactic S-ICD (26 patients) or a single right ventricular lead TV-ICD (17 patients) at seven experienced centers in Germany. Follow-up was performed bi-annually, at the end of which the data concerning comorbidities and, if applicable, reason for death were checked and confirmed with patients' general practitioner, nephrologist and cardiologist. Results: The median follow up duration was 95.6 months (range 42.8–126.3 months). Baseline characteristics were without noteworthy significant differences between groups. During follow-up (FU), there were significantly more device-associated infections (HR 8.72, 95% confidence interval (CI), 1.18 to 12.85, p < 0.05) and device-associated hospitalizations (HR 10.20, 95% CI 1.22 to 84.61, p < 0.001), as well as a higher cardiovascular mortality (HR 9.17, 95% CI 1.12 to 8.33, p < 0.05), in the TV-ICD group. The number of patients requiring hospitalization for any reason was significantly higher in the TV-ICD group (HR 2.59, 95% CI 1.12 to 6.41, p < 0.05). There was no significant difference in overall mortality (HR 1.92, 95% CI 0.96 to 6.15, p = 0.274). Conclusions: Our data suggest that, in this extended follow-up in seriously compromised renal patients on dialysis, the S-ICD patients have statistically fewer device infections and hospitalizations as well as lower cardiac mortality compared with the TV-ICD cohort. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Clinical use of automatic pacemaker algorithms: results of the AUTOMATICITY registry

Author

Alings, Marco, Vireca, Elisa, Bastian, Dirk, Wardeh, Alexander Jacques, Nimeth, Christopher, Tukkie, Raymond, Trinks, Susanne, Kainz, Walter, Delaney, Colleen, Kaltofen, Gert, Ziekenhuis, Amphia, Bloch-Thomsen, Poul Erik, Cihalik, Cestmir, Lawo, Thomas, Agraou, Benaissa, Deutsch, Philippe, Bazin, Patrick, Guyomar, Yves, Bobillier, Marc, Defaye, Pascal, Amiel, Alain, Lazarus, Arnaud, Guenoun, Maxime, Le Franc, Pierre, Oei, Fanny L., Nicastia, D., Hoenen, Stefan, de Porto, A.E., Vontobel, Heiner, Robles de Medina, Ramon, Kainz, Walter, Brunner, Philippe, Alzueta, Javier, Santos, Jose Antonio, Navarro, Alejandro Bellver, Hie, C., Kautzner, Josef, Ammann-Kardiol, Peter, Kaltofen, Gert, Tukkie, Raymond, Zeindlhofer, Eduard, Nimeth, Christopher, Frömmel, Martin, Brachmann, Johannes, Göhl, Konrad, Trinks, Susanne, van der Meer, Peter, Zenker, Gerald, Gebetsberger, Franz, Unger, Tilmann, Ruiter, Jacob H., Ramanna, Hemanth, Hadj, K.B., Lang, Andreas, Predel, Diethard, Schnabel, Andreas, Martinek, Martin, Cheng, Cheung-Wah, Ward, Kevin, Jensen, Gunnar, OʼNunain, Sean, Jiang, Shan, Terpstra, W.F., Budschedl, Erich, van Doorn, D.J., Marenne, Frédéric, Wahlers, Thorsten, Zeus, Tobias, Osswald, Stefan, Engby, Birger, Christensen, Per Dahl, Junbo, Ge, and van der Veen, Maurits

Published
2011
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28. Effectiveness of single‐ vs dual‐coil implantable defibrillator leads: An observational analysis from the SIMPLE study

Author

Neuzner, Jörg, primary, Hohnloser, Stefan H., additional, Kutyifa, Valentina, additional, Glikson, Michael, additional, Dietze, Thomas, additional, Mabo, Philippe, additional, Vinolas, Xavier, additional, Kautzner, Josef, additional, O'Hara, Gilles, additional, Lawo, Thomas, additional, Brachmann, Johannes, additional, VanErven, Liselot, additional, Gadler, Fredrik, additional, Appl, Ursula, additional, Wang, Jia, additional, Connolly, Stuart J., additional, and Healey, Jeff S., additional

Published
2019
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29. Cardiac contractility modulation treatment in patients with symptomatic heart failure despite optimal medical therapy and cardiac resynchronization therapy (CRT)

Author

Kuschyk, Jürgen, primary, Nägele, Herbert, additional, Heinz-Kuck, Karl, additional, Butter, Christian, additional, Lawo, Thomas, additional, Wietholt, Dietmar, additional, Roeger, Susanne, additional, Gutterman, David, additional, Burkhoff, Daniel, additional, Rousso, Benny, additional, and Borggrefe, Martin, additional

Published
2019
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33. Non-invasive Determination of the Optimized Atrioventricular Delay in Patients with Implanted Biventricular Pacing Devices

Author

Deneke, Thomas, Lawo, Thomas, von Dryander, Stefan, Grewe, Peter Hubert, Germing, Alfried, Gorr, Eduard, Hubben, Peter, Mugge, Andreas, Shin, Dong-In, and Lemke, Bernd

Subjects
Doppler-echocardiography, lcsh:Diseases of the circulatory (Cardiovascular) system, lcsh:RC666-701, biventricular pacing, atrioventricular-delay, Original Article, cardiac resynchronization
Abstract

Background: Biventricular (BiV) is extensively used in the treatment of congestive heart failure but so far no recommendations for optimized programming of atrioventricular-delay (AVD) settings have been proposed. Can AVD optimization be performed using a simple formula based on non-invasive doppler-echocardiography?Methods: 25 patients (ejection fraction 30±8%) received BiV ICDs. Doppler-echocardiographic evaluation of diastolic and systolic flow was performed for different AVDs (30ms to 150ms) and different stimulation sites (left ventricular (LV), right ventricular and BiV). The optimal atrioventricular delay was calculated applying a simple formula based on systolic and diastolic mechanical delays determined during doppler-echocardiography.Results: The mean optimal AVD was calculated to be 112±29ms (50 to 180ms) for BiV, 95±30ms (65 to 150ms) for LV and 75±28ms (40 to 125ms) for right ventricular pacing with wide interindividual variations. Compared to suboptimal AVDs diastolic optimization improved preejection and ejection intervals independent to pacing site. Optimization of the AVD significantly increased ejection time during BiV pacing (279ms versus 266ms; p

Published
2010

35. Predictors of Recurrence After Catheter Ablation of Persistent Atrial Fibrillation

Author

Deneke, Thomas, Schade, Anja, Krug, Joachim, Stahl, Karsten, Atilla Szollosi, Geza, In Shin, Dong, Nino Schukro, Clemens, El Tarahony, Mohamed, Murillo, Enrique, Aram, Semko, Robhirt, Gabriele, Lawo, Thomas, Mugge, Andreas, Grewe, Peter H., and Kerber, Sebastian

Subjects
Featured Review
Abstract

Catheter ablation of atrial fibrillation (AF) has been increasingly used to treat symptomatic patients.Within the last years a growing interest in ablation of persistent AF forms has evolved.Factors that may influence outcome of these procedures to treat persistent AF may be patient-specific (pre-procedural),procedure-related or may involve different post-ablation followup strategies. In this review potential factors predicting recurrence of AF after ablation of persistent AF have been evaluated.In essence, data is limited mostly due to incongruent definitions of persistent AF.Left atrial dimensions, duration of continuous AF and AF cycle length may be patient-specific predictors of outcome. Intra-procedural parameters involved in recurrence prediction may be extent of ablation (effective pulmonary vein isolation appears mandatory) and termination of AF during ablation. Timing and number of cardioversion if persistent AF recurs may predict outcome, as well. Many studies have identified strators for higher recurrence rates in rather small patient groups and need to be further evaluated in larger patient collectives.

Published
2012

36. Shift in the pattern of autonomic atrial innervation in subjects with persistent atrial fibrillation

Author

Deneke, Thomas, Chaar, Huda, de Groot, Joris R., Wilde, Arthur A., Lawo, Thomas, Mundig, Johanna, Boesche, Leif, Muegge, Andreas, Grewe, Peter H., Deneke, Thomas, Chaar, Huda, de Groot, Joris R., Wilde, Arthur A., Lawo, Thomas, Mundig, Johanna, Boesche, Leif, Muegge, Andreas, and Grewe, Peter H.

Abstract

BACKGROUND Atrial fibrillation (AF) is a multifactorial disease of the atria. OBJECTIVE We studied the differences in the atrial autonomic innervation pattern in subjects with AF compared with sinus rhythm (SR). METHODS Preparation of postmortem isolated hearts of subjects with documented persistent AF (group A) and SR (group B) included: (1) histological sectioning of predefined areas and quantification of nerve density, and (2) differentiation using immunohistochemistry in adrenergic (sympathetic, tyrosine-hydroxylase antibody), cholinergic (parasympathetic, choline-acetyltransferase antibody) and mixed (adrenergic and cholinergic staining) nerves. RESULTS Characteristics of subjects in group A (N = 15) and group B (N = 24) did not differ. The mean overall nerve density was similar between groups (A: 0.31 +/- 0.25/mm(2); B: 0.35 +/- 0.25/mm(2); P = .87). Nerve density appeared higher in the region of the pulmonary vein ostia and antrum (group A: 0.38 +/- 0.21/mm(2); group B: 0.32 +/- 0.19/mm(2),) compared with other locations of the right and left atrium. A total of 2,224 (group A: 685; group B: 1539) nerves were differentiated using immunohistochemistry. There was a high degree of colocalization of adrenergic and cholinergic nerves (group A: 80% mixed staining, group B: 69% mixed staining). In group A hearts there was a significantly lower density of predominantly cholinergic nerves (0.025 +/- 0.052/mm(2) vs. 0.058 +/- 0.099/mm(2); P = .008) and a higher density of nerves containing adrenergic components (0.24 +/- 0.18/mm(2) vs. 0.18 +/- 0.17/mm(2), P = .046). CONCLUSION Overall autonomic nerve density did not differ between atria with persistent AF compared with SR. On a morphological level, we detected a shift toward a lower density of cholinergic nerves and a higher density of nerves containing adrenergic components in AF subjects.

Published
2011

42. Evaluation of the Safety and Efficacy of the OPTIMIZER™ II and III Systems with Active Fixation Leads in Subjects with HF Resulting from Systolic Dysfunction: FIX-CHF-4

Author

Borggrefe, Martin M., primary, Lawo, Thomas, additional, Butter, Christian, additional, Schmidinger, Herwig, additional, Lunati, Maurizio, additional, Pieske, Burkert, additional, Misier, A. Ramdat, additional, Curnis, Antonio, additional, Böcker, Dirk, additional, Remppis, Andrew, additional, Kautzner, Joseph, additional, Stühlinger, Markus, additional, Leclerq, Christophe, additional, Táborský, Miloš, additional, Burkhoff, Daniel, additional, and Hindricks, Gerhard, additional

Published
2006
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