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8. Topical vanadate improves tensile strength and alters collagen organisation of excisional wounds in a mouse model

Author

Lintel, Hendrik, primary, Abbas, Darren B., additional, Mackay, Duncan J., additional, Griffin, Michelle, additional, Lavin, Christopher V., additional, Berry, Charlotte E., additional, Guardino, Nicholas J., additional, Guo, Jason L., additional, Momeni, Arash, additional, Mackay, Donald R., additional, Longaker, Michael T., additional, and Wan, Derrick C., additional

Published
2022
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10. Decellularized Adipose Matrices Can Alleviate Radiation-Induced Skin Fibrosis

Author

Adem, Sandeep, primary, Abbas, Darren B., additional, Lavin, Christopher V., additional, Fahy, Evan J., additional, Griffin, Michelle, additional, Diaz Deleon, Nestor M., additional, Borrelli, Mimi R., additional, Mascharak, Shamik, additional, Shen, Abra H., additional, Patel, Ronak A., additional, Longaker, Michael T., additional, Nazerali, Rahim S., additional, and Wan, Derrick C., additional

Published
2022
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11. Understanding Scarring in the Oral Mucosa

Author

Griffin, Michelle F., primary, Fahy, Evan J., additional, King, Megan, additional, Guardino, Nicholas, additional, Chen, Kellen, additional, Abbas, Darren B., additional, Lavin, Christopher V., additional, Diaz Deleon, Nestor M., additional, Lorenz, H. Peter, additional, Longaker, Michael T., additional, and Wan, Derrick C., additional

Published
2022
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14. Standardizing Dimensionless Cutometer Parameters to Determine In Vivo Elasticity of Human Skin

Author

Abbas, Darren B., primary, Lavin, Christopher V., additional, Fahy, Evan J., additional, Griffin, Michelle, additional, Guardino, Nicholas, additional, King, Megan, additional, Chen, Kellen, additional, Lorenz, P. Hermann, additional, Gurtner, Geoffrey C., additional, Longaker, Michael T., additional, Momeni, Arash, additional, and Wan, Derrick C., additional

Published
2022
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17. 109. Vitamin E Treated Fat Grafts Maintain Volume to Improve Grafting Effects on Radiation-induced Fibrosis

Author

Abbas, Darren B., primary, Lavin, Christopher V., additional, Fahy, Evan J., additional, Lintel, Hendrik, additional, Griffin, Michelle, additional, Pu, Adrian, additional, Nazerali, Rahim, additional, Nguyen, Dung, additional, Momeni, Arash, additional, Lorenz, H. Peter, additional, Longaker, Michael T., additional, and Wan, Derrick C., additional

Published
2022
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31. Dermal Iron Chelation Reduces Indirect Radiation Injury

Author

Lavin, Christopher V., primary, Fahy, Evan J., additional, Abbas, Darren B., additional, griffin, michelle, additional, Lee, Daniel K., additional, Diaz Deleon, Nestor M., additional, Guardino, Nicholas, additional, Gurtner, Geoffrey C., additional, Longaker, Michael T., additional, and Wan, Derrick C., additional

Published
2021
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35. Topical vanadate improves tensile strength and alters collagen organisation of excisional wounds in a mouse model.

Author

Lintel, Hendrik, Abbas, Darren B., Mackay, Duncan J., Griffin, Michelle, Lavin, Christopher V., Berry, Charlotte E., Guardino, Nicholas J., Guo, Jason L., Momeni, Arash, Mackay, Donald R., Longaker, Michael T., and Wan, Derrick C.

Subjects
SKIN injuries, WOUND healing, COLLAGEN, BIOLOGICAL models, VANADATES, ANIMAL experimentation, SURGICAL wound dehiscence, TENSILE strength, SURGICAL site, BIOMECHANICS, MICE
Abstract

Wound dehiscence, oftentimes a result of the poor tensile strength of early healing wounds, is a significant threat to the post‐operative patient, potentially causing life‐threatening complications. Vanadate, a protein tyrosine phosphatase inhibitor, has been shown to alter the organisation of deposited collagen in healing wounds and significantly improve the tensile strength of incisional wounds in rats. In this study, we sought to explore the effects of locally administered vanadate on tensile strength and collagen organisation in both the early and remodelling phases of excisional wound healing in a murine model. Wild‐type mice underwent stented excisional wounding on their dorsal skin and were divided equally into three treatment conditions: vanadate injection, saline injection control and an untreated control. Tensile strength testing, in vivo suction Cutometer analysis, gross wound measurements and histologic analysis were performed during healing, immediately upon wound closure, and after 4 weeks of remodelling. We found that vanadate treatment significantly increased the tensile strength of wounds and their stiffness relative to control wounds, both immediately upon healing and into the remodelling phase. Histologic analysis revealed that these biomechanical changes were likely the result of increased collagen deposition and an altered collagen organisation composed of thicker and distinctly organised collagen bundles. Given the risk that dehiscence poses to all operative patients, vanadate presents an interesting therapeutic avenue to improve the strength of post‐operative wounds and unstable chronic wounds to reduce the risk of dehiscence. [ABSTRACT FROM AUTHOR]

Published
2023
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36. A comparative analysis of deferoxamine treatment modalities for dermal radiation‐induced fibrosis

Author

Lavin, Christopher V., primary, Abbas, Darren B., additional, Fahy, Evan J., additional, Lee, Daniel K., additional, Griffin, Michelle, additional, Diaz Deleon, Nestor M., additional, Mascharak, Shamik, additional, Chen, Kellen, additional, Momeni, Arash, additional, Gurtner, Geoffrey C., additional, Longaker, Michael T., additional, and Wan, Derrick C., additional

Published
2021
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37. Angiogenic CD34+CD146+ adipose‐derived stromal cells augment recovery of soft tissue after radiotherapy

Author

Deleon, Nestor M. Diaz, primary, Adem, Sandeep, additional, Lavin, Christopher V., additional, Abbas, Darren B., additional, Griffin, Michelle, additional, King, Megan E., additional, Borrelli, Mimi R., additional, Patel, Ronak A., additional, Fahy, Evan J., additional, Lee, Daniel, additional, Shen, Abra H., additional, Momeni, Arash, additional, Longaker, Michael T., additional, and Wan, Derrick C., additional

Published
2021
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39. Readability of Online Patient Information Relating to Cleft Palate Surgery.

Author

Lavin, Christopher V., Fahy, Evan J., Abbas, Darren B., Griffin, Michelle, Deleon, Nestor M. Diaz, Lee, Daniel K., Khosla, Rohit K., Bruckman, Karl, Lorenz, Hermann Peter, and Wan, Derrick C.

Subjects
MEDICINE information services, READABILITY (Literary style), INTERNET, CLEFT palate, HEALTH information services, TEACHING aids, SEARCH engines, DESCRIPTIVE statistics, PATIENT education
Abstract

Objective: It is important for health care education materials to be easily understood by caretakers of children requiring craniofacial surgery. This study aimed to analyze the readability of Google search results as they pertain to "Cleft Palate Surgery" and "Palatoplasty." Additionally, the study included a search from several locations globally to identify possible geographic differences. Design: Google searches of the terms "Cleft Palate Surgery" and "Palatoplasty" were performed. Additionally, searches of only "Cleft Palate Surgery" were run from several internet protocol addresses globally. Main Outcome Measures: Flesch-Kincaid Grade Level and Readability Ease, Gunning Fog Index, Simple Measure of Gobbledygook (SMOG) index, and Coleman-Liau Index. Results: Search results for "Cleft Palate Surgery" were easier to read and comprehend compared to search results for "Palatoplasty." Mean Flesch-Kincaid Grade Level scores were 7.0 and 10.11, respectively (P =.0018). Mean Flesch-Kincaid Reading Ease scores were 61.29 and 40.71, respectively (P =.0003). Mean Gunning Fog Index scores were 8.370 and 10.34, respectively (P =.0458). Mean SMOG Index scores were 6.84 and 8.47, respectively (P =.0260). Mean Coleman-Liau Index scores were 12.95 and 15.33, respectively (P =.0281). No significant differences were found in any of the readability measures based on global location. Conclusions: Although some improvement can be made, craniofacial surgeons can be confident in the online information pertaining to cleft palate repair, regardless of where the search is performed from. The average readability of the top search results for "Cleft Palate Surgery" is around the seventh-grade reading level (US educational system) and compares favorably to other health care readability analyses. [ABSTRACT FROM AUTHOR]

Published
2022
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41. Standardizing Dimensionless Cutometer Parameters to Determine In VivoElasticity of Human Skin

Author

Abbas, Darren B., Lavin, Christopher V., Fahy, Evan J., Griffin, Michelle, Guardino, Nicholas, King, Megan, Chen, Kellen, Lorenz, P. Hermann, Gurtner, Geoffrey C., Longaker, Michael T., Momeni, Arash, and Wan, Derrick C.

Abstract

Objective:Skin fibrosis places an enormous burden on patients and society, but disagreement exists over methods to quantify severity of skin scarring. A suction cutometer measures skin elasticity in vivo, but it has not been widely adopted because of inconsistency in data produced. We investigated variability of several dimensionless parameters generated by the cutometer to improve their precision and accuracy.Approach:Twenty adult human subjects underwent suction cutometer measurement of normal skin (NS) and fibrotic scars (FS). Using Mode 1, each subject underwent five trials with each trial containing four curves. R0/2/5/6/7 and Q1/2/3 data were collected. Analyses were performed on these calculated parameters.Results:R0/2/5/6/7 and Q1/2 parameters from curves 1 to 4 demonstrated significant differences, whereas these same parameters were not significantly different when only using curves 2–4. Individual analysis of all parameters between curve 1 and every subsequent curve was statistically significant for R0, R2, R5, R6, R7, Q1, and Q2. No differences were appreciated for parameter Q3. Comparison between NS and FS were significantly different for parameters R5, Q1, and Q3.Innovation:Our study is the first demonstration of accurate comparison between NS and FS using the dimensionless parameters of a suction cutometer.Conclusions:Measured parameters from the first curve of each trial were significantly different from subsequent curves for both NS and FS. Precision and reproducibility of data from dimensionless parameters can therefore be improved by removing the first curve. R5, Q1, and Q3 parameters differentiated NS as more elastic than FS.

Published
2022
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43. Readability of Online Patient Information Relating to Cleft Palate Surgery.

Author

Lavin CV, Fahy EJ, Abbas DB, Griffin M, Deleon NMD, Lee DK, Khosla RK, Bruckman K, Lorenz HP, and Wan DC

Subjects
Child, Comprehension, Humans, Internet, Smog, Cleft Palate surgery, Health Literacy, Surgery, Oral
Abstract

Objective: It is important for health care education materials to be easily understood by caretakers of children requiring craniofacial surgery. This study aimed to analyze the readability of Google search results as they pertain to "Cleft Palate Surgery" and "Palatoplasty." Additionally, the study included a search from several locations globally to identify possible geographic differences., Design: Google searches of the terms "Cleft Palate Surgery" and "Palatoplasty" were performed. Additionally, searches of only "Cleft Palate Surgery" were run from several internet protocol addresses globally., Main Outcome Measures: Flesch-Kincaid Grade Level and Readability Ease, Gunning Fog Index, Simple Measure of Gobbledygook (SMOG) index, and Coleman-Liau Index., Results: Search results for "Cleft Palate Surgery" were easier to read and comprehend compared to search results for "Palatoplasty." Mean Flesch-Kincaid Grade Level scores were 7.0 and 10.11, respectively ( P = .0018). Mean Flesch-Kincaid Reading Ease scores were 61.29 and 40.71, respectively ( P = .0003). Mean Gunning Fog Index scores were 8.370 and 10.34, respectively ( P = .0458). Mean SMOG Index scores were 6.84 and 8.47, respectively ( P = .0260). Mean Coleman-Liau Index scores were 12.95 and 15.33, respectively ( P = .0281). No significant differences were found in any of the readability measures based on global location., Conclusions: Although some improvement can be made, craniofacial surgeons can be confident in the online information pertaining to cleft palate repair, regardless of where the search is performed from. The average readability of the top search results for "Cleft Palate Surgery" is around the seventh-grade reading level (US educational system) and compares favorably to other health care readability analyses.

Published
2022
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