28 results on '"Lavignolle, V"'
Search Results
2. Association of non-HDL cholesterol with subclinical atherosclerosis in HIV-positive patients
- Author
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Badiou, S., Thiebaut, R., Aurillac-Lavignolle, V., Dabis, F., Laporte, F., Cristol, J.P., and Mercie, P.
- Published
- 2008
- Full Text
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3. Carotid intima–media thickness is slightly increased over time in HIV-1-infected patients
- Author
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Mercié, P, Thiébaut, R, Aurillac-Lavignolle, V, Pellegrin, J L, Yvorra-Vives, M C, Cipriano, C, Neau, D, Morlat, P, Ragnaud, J M, Dupon, M, Bonnet, F, Lawson-Ayayi, S, Malvy, D, Roudaut, R, and Dabis, F
- Published
- 2005
4. Combination antiretroviral therapy and the risk of myocardial infarction
- Author
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Friis-Moller, N, Sabin, CA, Weber, R, Monforte, AD, El-Sadr, WM, Reiss, P, Thiebaut, R, Morfeldt, L, De Wit, S, Pradier, C, Calvo, G, Law, MG, Kirk, O, Phillips, AN, Lundgren, JD, Monteforte, AD, Bartsch, G, Dabis, F, Houyez, F, Loeliger, E, Tressler, R, Weller, I., Sjol, A, Sawitz, A, Rickenbach, M, Pezzotti, P, Krum, E, Meester, R, Lavignolle, V., Mulder, J, van der Meer, J, Sprenger, HG, Koopmans, P, Borleffs, J, Crane, LR, Johnson, MA, Martinelli, C, University of Groningen, Global Health, Infectious diseases, Other departments, Public and occupational health, AII - Amsterdam institute for Infection and Immunity, Center of Experimental and Molecular Medicine, and Faculteit der Geneeskunde
- Subjects
Adult ,Male ,medicine.medical_specialty ,Myocardial Infarction ,HIV Infections ,HIV-INFECTED PATIENTS ,HEART-DISEASE ,HIV-1-INFECTED PATIENTS ,Coronary artery disease ,Pharmacotherapy ,Risk Factors ,Internal medicine ,medicine ,Humans ,Poisson Distribution ,Prospective Studies ,Myocardial infarction ,Prospective cohort study ,LIPODYSTROPHY ,Reverse-transcriptase inhibitor ,business.industry ,Incidence ,Incidence (epidemiology) ,Absolute risk reduction ,General Medicine ,ASSOCIATION ,ADULTS ,Middle Aged ,medicine.disease ,CD4 Lymphocyte Count ,Surgery ,Regimen ,PROTEASE INHIBITORS ,Anti-Retroviral Agents ,MONICA PROJECT ,HIV-1 ,Regression Analysis ,CORONARY-ARTERY-DISEASE ,EVENT RATES ,Drug Therapy, Combination ,Female ,business ,Follow-Up Studies ,medicine.drug - Abstract
BACKGROUND: It remains controversial whether exposure to combination antiretroviral treatment increases the risk of myocardial infarction. METHODS: In this prospective observational study, we enrolled 23,468 patients from 11 previously established cohorts from December 1999 to April 2001 and collected follow-up data until February 2002. Data were collected on infection with the human immunodeficiency virus and on risk factors for and the incidence of myocardial infarction. Relative rates were calculated with Poisson regression models. Combination antiretroviral therapy was defined as any combination regimen of antiretroviral drugs that included a protease inhibitor or a nonnucleoside reverse transcriptase inhibitor. RESULTS: Over a period of 36,199 person-years, 126 patients had a myocardial infarction. The incidence of myocardial infarction increased with longer exposure to combination antiretroviral therapy (adjusted relative rate per year of exposure, 1.26 [95 percent confidence interval, 1.12 to 1.41]; P
- Published
- 2003
- Full Text
- View/download PDF
5. Predicting the risk of cardiovascular disease in HIV-infected patients: the data collection on adverse effects of anti-HIV drugs study
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Friis Møller, N, Thiébaut, R, Reiss, P, Weber, R, Monforte, Ad, De Wit, S, El Sadr, W, Fontas, E, Worm, S, Kirk, O, Phillips, A, Sabin, Ca, Lundgren, Jd, Law, Mg, Collaborators: Collins S, DAD study g. r. o. u. p., Pearce, G, Storfer, S, Rhode, R, Worm, Sw, Tverland, J, Kamara, A, Sjøl, S, Sawitz, A, Brandt, Rs, Rickenbach, M, Fanti, L, Krum, E, Gras, L, Geffard, S, Sundström, A, Delforge, M, Torres, F, Mcmanus, H, Wright, S, Kjaer, J, de Wolf, F, Zaheri, S, Bronsveld, W, Hillebrand Haverkort ME, Prins, Jm, Bos, Jc, Eeftinck Schattenkerk JK, Geerlings, Se, Godfried, Mh, Lange, Jm, van Leth FC, Lowe, Sh, van der Meer JT, Nellen, Fj, Pogány, K, van der Poll, T, Ruys, Ta, Sankatsing, Steingrover, R, van Twillert, G, van der Valk, M, van Vonderen MG, Vrouenraets, Sm, van Vugt, M, Wit, Fw, van Eeden, A, ten Veen JH, van Dam PS, Roos, Jc, Brinkman, K, Frissen, Ph, Weigel, Hm, Mulder, Jw, van Gorp EC, Meenhorst, Pl, Mairuhu, At, Veenstra, J, Danner, Sa, Van Agtmael MA, Claessen, Fa, Perenboom, Rm, Rijkeboer, A, van Vonderen, M, Richter, C, van der Berg, J, van Leusen, R, Vriesendorp, R, Jeurissen, Fj, Kauffmann, Rh, Koger, El, Bravenboer, B, ten Napel CH, Kootstra, Gj, Sprenger, Hg, Miesen, Wm, Doedens, R, Scholvinck, Eh, ten Kate RW, van Houte DP, Polee, M, Kroon, Fp, van den Broek, van Dissel JT, Schippers, Ef, Schreij, G, van de Geest, S, Verbon, A, Koopmans, Pp, Keuter, M, Post, F, van der Ven AJ, van der Ende ME, Gyssens, Ic, van der Feltz, M, den Hollander JG, de Marie, S, Nouwen, Jl, Rijnders, Bj, de Vries TE, Juttmann, Jr, van de Heul, C, van Kasteren ME, Elisabeth, S, Schneider, Mm, Bonten, Mj, Borleffs, Jc, Ellerbroek, Pm, Hoepelman, Im, Jaspers, Ca, Schouten, I, Schurink, Ca, Blok, Wl, Tanis, Aa, Groeneveld, Ph, Salamon, R, Beylot, J, Le Bras, M, Dupon, M, Pellegrin, Jl, Ragnaud, Jm, Dabis, F, Chêne, G, Lawson Ayayi, S, Blaizeau, Mj, Decoin, M, Delveaux, S, Hannapier, C, D'Ivernois, C, Leleux, O, Uwamaliya Nziyumvira, B, Palmer, G, Touchard, D, Jacqmin Gadda, H, Lavignolle, V, Balestre, E, Formaggio, Am, Labarerre, S, Vimard, E, Dutoit, D, Pereira, F, Boulant, B, Bonnal, F, Farbos, S, Bonarek, M, Bonnet, F, Bernard, N, Caubet, O, Cazanave, C, Dauchy, Fa, De La Taille, C, Duffau, P, Dutronc, H, Greib, C, Lacoste, D, Lafarie, S, Lazaro, E, Malvy, D, Mercié, P, Morlat, P, Neau, D, Ochoa, A, Pillot Debelleix, M, Pistone, T, Receveur, Mc, Vandenhende, Ma, Viallard, Jf, Blanco, P, Moreau, Jf, Fleury, H, Lafon, Me, Masquelier, B, Pellegrin, I, Breilh, D, Miremont Salamé, G, Caunègre, L, Gerard, Y, Loste, P, Ceccaldi, J, Tchamgoué, S, De Witte, S, Law, M, Petoumenos, K, Moore, R, Edwards, S, Hoy, J, Watson, K, Roth, N, Nicholson, J, Bloch, M, Franic, T, Baker, D, Mcfarlane, R, Carr, A, Cooper, D, Chuah, J, Fankhauser, W, Nolan, D, Mallal, S, Forsdyke, C, Calvo, G, Mateu, S, Domingo, P, Sambeat, Ma, Gatell, J, Del Cacho, E, Cadafalch, J, Fuster, M, Codina, C, Sirera, G, Vaqué, A, Clumeck, N, Gerard, M, Kabeya, K, Konopnicki, D, Libois, A, Payen, Mc, Poll, B, Van Laethem, Y, Neaton, J, Bartsch, G, El Sadr WM, Thompson, G, Wentworth, D, Luskin Hawk, R, Telzak, E, Abrams, Di, Cohn, D, Markowitz, N, Mushatt, D, Friedland, G, Perez, G, Tedaldi, E, Fisher, E, Gordin, F, Crane, Lr, Sampson, J, Baxter, J, Mocroft, A, Ellefson, M, Phillips, An, Losso, M, Elias, C, Vetter, N, Zangerle, R, Karpov, I, Vassilenko, A, Mitsura, Vm, Suetnov, O, Colebunders, R, Vandekerckhove, L, Hadziosmanovic, V, Kostov, K, Begovac, I, Machala, L, Rozsypal, H, Sedlacek, D, Nielsen, J, Kronborg, G, Benfield, T, Larsen, M, Gerstoft, J, Katzenstein, T, Hansen, Ab, Skinhøj, P, Pedersen, C, Oestergaard, L, Zilmer, K, Smidt, J, Ristola, M, Katlama, C, Viard, Jp, Girard, Pm, Livrozet, Jm, Vanhems, P, Pradier, C, Rockstroh, J, Schmidt, R, van Lunzen, J, Degen, O, Stellbrink, Hj, Staszewski, S, Bogner, J, Fätkenheuer, G, Kosmidis, J, Gargalianos, P, Xylomenos, G, Perdios, J, Panos, G, Filandras, A, Karabatsaki, E, Sambatakou, H, Banhegyi, D, Mulcahy, F, Yust, I, Turner, D, Burke, M, Pollack, S, Hassoun, G, Maayan, S, Chiesi, A, Esposito, R, Mazeu, I, Mussini, C, Arici, C, Pristera, R, Mazzotta, F, Gabbuti, A, Vullo, V, Lichtner, M, Chirianni, A, Montesarchio, E, Gargiulo, M, Antonucci, G, Iacomi, F, Narciso, P, Vlassi, C, Zaccarelli, M, Lazzarin, A, Finazzi, R, Galli, M, Ridolfo, A, d'Arminio Monforte, A, Rozentale, B, Aldins, P, Chaplinskas, S, Hemmer, R, Staub, T, Bruun, J, Maeland, A, Ormaasen, V, Knysz, B, Gasiorowski, J, Horban, A, Bakowska, E, Prokopowicz, D, Flisiak, R, Boron Kaczmarska, A, Pynka, M, Beniowski, M, Mularska, E, Trocha, H, Jablonowska, E, Malolepsza, E, Wojcik, K, Antunes, F, Valadas, E, Mansinho, K, Maltez, F, Duiculescu, D, Rakhmanova, A, Vinogradova, E, Buzunova, S, Jevtovic, D, Mokrás, M, Staneková, D, Tomazic, J, González Lahoz, J, Soriano, V, Martin Carbonero, L, Labarga, P, Moreno, S, Clotet, B, Jou, A, Paredes, R, Tural, C, Puig, J, Bravo, I, Gatell, Jm, Miró, Jm, Gutierrez, M, Mateo, G, Karlsson, A, Persson, Po, Flamholc, L, Ledergerber, B, Francioli, Cavassini, M, Hirschel, B, Boffi, E, Furrer, H, Battegay, M, Elzi, L, Kravchenko, E, Chentsova, N, Kutsyna, G, Servitskiy, S, Antoniak, S, Krasnov, M, Barton, S, Johnson, Am, Mercey, D, Johnson, Ma, Murphy, M, Weber, J, Scullard, G, Fisher, M, Leen, C, Morfeldt, L, Thulin, G, Akerlund, B, Koppel, K, Håkangård, C, Moroni, M, Antinori, A, Carosi, Giampiero, Cauda, R, Chiodo, F, Di Perri, G, Ghinelli, F, Iardino, R, Ippolito, G, Panebianco, R, Pastore, G, Perno, Cf, Pezzotti, P, Montroni, M, Scalise, G, Costantini, A, Riva, A, Tirelli, U, Martellotta, F, Ladisa, N, Suter, F, Maggiolo, F, Colangeli, V, Fiorini, C, Carosi, G, Cristini, G, Torti, Carlo, Minardi, C, Bertelli, D, Quirino, T, Manconi, Pe, Piano, P, Pizzigallo, E, D'Alessandro, M, Carnevale, G, Zoncada, A, Sighinolfi, L, Leoncini, F, Pozzi, M, Lo Caputo, S, Grisorio, B, Ferrara, S, Pagano, G, Cassola, G, Alessandrini, A, Piscopo, R, Soscia, F, Tacconi, L, Orani, A, Perini, P, Tommasi, D, Congedo, P, Chiodera, F, Castelli, P, Rizzardini, G, Caggese, L, Galli, A, Merli, S, Pastecchia, C, Moioli, Mc, Gori, A, Cagni, S, Abrescia, N, Izzo, Cm, De Marco, M, Viglietti, R, Manzillo, E, Ferrari, C, Pizzaferri, P, Filice, G, Bruno, R, Magnani, G, Ursitti, Ma, Arlotti, M, Ortolani, P, Andreoni, M, Tozzi, V, De Luca, A, Acinapura, R, De Longis, P, Trotta, Mp, Carletti, F, Mura, Ms, Mannazzu, M, Caramello, P, Orofino, Gc, Sciandra, M, Raise, E, Ebo, F, Pellizzer, G, Buonfrate, D, Caissotti, C, Dellamonica, P, Bentz, L, Bernard, E, De Salvador Guillouet, F, Durant, J, Mondain Miton, V, Perbost, I, Prouvost Keller, B, Pugliese, P, Rahelinirina, V, Roger, Pm, Cua, E, Farhad, R, Ferrando, S, Vassallo, M, Baëz, E, Bernasconi, E, and Böni, J.
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- 2010
6. High prevalence of the metabolic syndrome in HIV-infected patients: impact of different definitions of the metabolic syndrome
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de Wolf, F, Zaheri, S, Gras, L, Bronsveld, W, Hillebrand Haverkort, Me, Prins, Jm, Bos, Jc, Eeftinck Schattenkerk, Jk, Geerlings, Se, Godfried, Mh, Lange, Jm, van Leth, Fc, Lowe, Sh, van der Meer, Jt, Nellen, Fj, Pogány, K, van der Poll, T, Reiss, P, Ruys, Ta, Steingrover, R, van Twillert, G, van der Valk, M, van Vonderen, Mg, Vrouenraets, Sm, van Vugt, M, Wit, Fw, van Eeden, A, ten Veen, Jh, van Dam, Ps, Roos, Jc, Brinkman, K, Frissen, Ph, Weigel, Hm, Mulder, Jw, van Gorp, Ec, Meenhorst, Pl, Mairuhu, At, Veenstra, J, Danner, Sa, Van Agtmael, Ma, Claessen, Fa, Perenboom, Rm, Rijkeboer, A, van Vonderen, M, Richter, C, van der Berg, J, van Leusen, R, Vriesendorp, R, Jeurissen, Fj, Kauffmann, Rh, Koger, El, Bravenboer, B, ten Napel, Ch, Kootstra, Gj, Sprenger, Hg, Miesen, Wm, Doedens, R, Scholvinck, Eh, ten Kate, Rw, van Houte, Dp, Polee, M, Kroon, Fp, van Dissel, Jt, Schippers, Ef, Schreij, G, van de Geest, S, Verbon, A, Koopmans, Pp, Keuter, M, Post, F, van der Ven, Aj, van der Ende, Me, Gyssens, Ic, van der Feltz, M, den Hollander, Jg, de Marie, S, Nouwen, Jl, Rijnders, Bj, de Vries, Te, Juttmann, Jr, van de Heul, C, van Kasteren, Me, Elisabeth, S, Schneider, Mm, Bonten, Mj, Borleffs, Jc, Ellerbroek, Pm, Hoepelman, Im, Jaspers, Ca, Schouten, I, Schurink, Ca, Blok, Wl, Tanis, Aa, Groeneveld, Ph, Salamon, R, Beylot, J, Dupon, M, Le Bras, M, Pellegrin, Jl, Ragnaud, Jm, Dabis, F, Chêne, G, Jacqmin Gadda, H, Thiébaut, R, Lawson Ayayi, S, Lavignolle, V, Balestre, E, Blaizeau, Mj, Decoin, M, Formaggio, Am, Delveaux, S, Labarerre, S, Uwamaliya, B, Vimard, E, Merchadou, L, Palmer, G, Touchard, D, Dutoit, D, Pereira, F, Boulant, B, Morlat, P, Bernard, N, Bonarek, M, Bonnet, F, Coadou, B, Gelie, P, Jaubert, D, Nouts, C, Lacoste, D, Dutronc, H, Cipriano, G, Lafarie, S, Chossat, I, Lacut, Jy, Leng, B, Mercie, P, Viallard, Jf, Faure, I, Rispal, P, Cipriano, C, Tchamgoué, S, Djossou, F, Malvy, D, Pivetaud, Jp, Chambon, D, De La Taille, C, Galperine, T, Neau, D, Ochoa, A, Beylot, C, Doutre, Ms, Bezian, Jh, Moreau, Jf, Taupin, Jl, Conri, C, Constans, J, Couzigou, P, Castera, L, Fleury, H, Lafon, Me, Masquelier, B, Pellegrin, I, Trimoulet, P, Moreau, F, Mestre, C, Series, C, Taytard, A, Law, M, Petoumenos, K, Anderson, J, Cortossis, P, Hoy, J, Watson, K, Roth, N, Nicholson, J, Bloch, M, Franic, T, Baker, D, Mcfarlane, R, Carr, A, Cooper, D, Chuah, J, Fankhauser, W, Mallal, S, Forsdyke, C, Calvo, G, Torres, F, Mateu, S, Domingo, P, Sambeat, Ma, Gatell, J, Del Cacho, E, Cadafalch, J, Fuster, M, Codina, C, Sirera, G, Vaqué, A, Clumeck, N, De Wit, S, Gerard, M, Kabeya, K, Konopnicki, D, Libois, A, Payen, Mc, Poll, B, Van Laethem, Y, Neaton, J, Bartsch, G, El Sadr, Wm, Krum, E, Thompson, G, Wentworth, D, Luskin Hawk, R, Telzak, E, Abrams, Di, Cohn, D, Markowitz, N, Arduino, R, Mushatt, D, Friedland, G, Perez, G, Tedaldi, E, Fisher, E, Gordin, F, Crane, Lr, Sampson, J, Baxter, J, Kirk, O, Mocroft, A, Ellefson, M, Phillips, An, Lundgren, Jd, Losso, M, Elias, C, Vetter, N, Zangerle, R, Karpov, I, Vassilenko, A, Mitsura, Vm, Suetnov, O, Colebunders, R, Vandekerckhove, L, Hadziosmanovic, V, Kostov, K, Begovac, I, Machala, L, Rozsypal, H, Sedlacek, D, Nielsen, J, Kronborg, G, Benfield, T, Larsen, M, Gerstoft, J, Katzenstein, T, Hansen, Ab, Skinhøj, P, Pedersen, C, Oestergaard, L, Zilmer, K, Ristola, M, Katlama, C, Viard, Jp, Girard, Pm, Livrozet, Jm, Vanhems, P, Pradier, C, Rockstroh, J, Schmidt, R, van Lunzen, J, Degen, O, Stellbrink, Hj, Staszewski, S, Bogner, J, Fätkenheuer, G, Gargalianos, P, Xylomenos, G, Perdios, J, Panos, G, Filandras, A, Karabatsaki, E, Sambatakou, H, Banhegyi, D, Mulcahy, F, Yust, I, Turner, D, Burke, M, Pollack, S, Hassoun, G, Maayan, S, Chiesi, A, Esposito, R, Mazeu, I, Mussini, C, Arici, C, Pristera, R, Mazzotta, F, Gabbuti, A, Vullo, V, Lichtner, M, Chirianni, A, Montesarchio, E, Gargiulo, M, Antonucci, G, Iacomi, F, Narciso, P, Vlassi, C, Zaccarelli, M, Lazzarin, A, Finazzi, R, Galli, M, Ridolfo, A, d'Arminio Monforte, A, Rozentale, B, Aldins, P, Chaplinskas, S, Hemmer, R, Staub, T, Bruun, J, Maeland, A, Ormaasen, V, Knysz, B, Gasiorowski, J, Horban, A, Bakowska, E, Prokopowicz, D, Flisiak, R, Boron Kaczmarska, A, Pynka, M, Beniowski, M, Mularska, E, Trocha, H, Jablonowska, E, Malolepsza, E, Wojcik, K, Antunes, F, Valadas, E, Maltez, F, Duiculescu, D, Rakhmanova, A, Vinogradova, E, Buzunova, S, Jevtovic, D, Mokrás, M, Staneková, D, Tomazic, J, González Lahoz, J, Soriano, V, Martin Carbonero, L, Labarga, P, Clotet, B, Jou, A, Paredes, R, Tural, C, Puig, J, Bravo, I, Gatell, Jm, Miró, Jm, Gutierrez, M, Mateo, G, Karlsson, A, Persson, Po, Flamholc, L, Ledergerber, B, Weber, R, Cavassini, M, Hirschel, B, Boffi, E, Furrer, H, Battegay, M, Elzi, L, Kravchenko, E, Chentsova, N, Kutsyna, G, Servitskiy, S, Antoniak, S, Krasnov, M, Barton, S, Johnson, Am, Mercey, D, Phillips, A, Johnson, Ma, Murphy, M, Weber, J, Scullard, G, Fisher, M, Leen, C, Morfeldt, L, Thulin, G, Sundström, A, Akerlund, B, Koppel, K, Håkangård, C, Moroni, M, Carosi, Giampiero, Cauda, R, Chiodo, F, Di Perri, G, Iardino, R, Ippolito, G, Panebianco, R, Pastore, G, Perno, Cf, Ammassari, A, Antinori, A, Balotta, C, Bonfanti, P, Capobianchi, Mr, Castagna, A, Ceccherini Silberstein, F, Cozzi Lepri, A, De Luca, A, Gervasoni, C, Girardi, E, Maggiolo, F, Murri, R, Puoti, M, Torti, C, Fanti, I, Formenti, T, Prosperi, M, Montroni, M, Giacometti, A, Costantini, A, Riva, A, Tirelli, U, Martellotta, F, Ladisa, N, Suter, F, Verucchi, G, Fiorini, C, Carosi, G, Cristini, G, Minardi, C, Bertelli, D, Quirino, T, Abeli, C, Manconi, Pe, Piano, P, Vecchiet, J, Farenga, M, Carnevale, G, Lorenzotti, S, Ghinelli, F, Sighinolfi, L, Leoncini, F, Pozzi, M, Pagano, G, Cassola, G, Viscoli, G, Alessandrini, A, Piscopo, R, Soscia, F, Tacconi, L, Orani, A, Rossotto, R, Tommasi, D, Congedo, P, Chiodera, A, Castelli, P, Rizzardini, G, Schlacht, I, Ridolfo, Al, Foschi, A, Salpietro, S, Merli, S, Melzi, S, Moioli, Mc, Cicconi, P, Gori, A, Abrescia, N, Izzo, Cm, De Marco, M, Viglietti, R, Manzillo, E, Ferrari, C, Pizzaferri, P, Baldelli, F, Camanni, G, Magnani, G, Ursitti, Ma, Arlotti, M, Ortolani, P, Andreoni, M, Tozzi, V, Acinapura, R, De Longis, P, Trotta, Mp, Carletti, F, Mura, Ms, Madeddu, G, Caramello, P, Orofino, Gc, Raise, E, Ebo, F, Pellizzer, G, Buonfrate, D, Fontas, E, Caissotti, C, Dellamonica, P, Bentz, L, Bernard, E, Cua, E, De Salvador Guillouet, F, Durant, J, Farhad, R, Ferrando, S, Mondain Miton, V, Perbost, I, Prouvost Keller, B, Pugliese, P, Rahelinirina, V, Roger, Pm, Vassallo, M, Baëz, E, Bernasconi, E, Böni, J, Bucher, H, Bürgisser, P, Cattacin, S, Dubs, R, Egger, M, Erb, P, Fischer, M, Flepp, M, Fontana, A, Francioli, P, Furrer, Hj, Gorgievski, M, Günthard, H, Kaiser, L, Kind, C, Klimkait, T, Lauper, U, Opravil, M, Paccaud, F, Pantaleo, G, Perrin, L, Piffaretti, Jc, Rickenbach, M, Rudin, C, Schmid, P, Schüpbach, J, Speck, R, Telenti, A, Trkola, A, Vernazza, P, and Yerly, S.
- Subjects
HIV ,metabolic syndrome - Published
- 2010
7. HIV-induced immunodeficiency and mortality from AIDS-defining and non-AIDS-defining malignancies
- Author
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Monforte, A, Abrams, D, Pradier, C, Weber, R, Reiss, P, Bonnet, F, Kirk, O, Law, M, De Wit, S, Friis Møller, N, Phillips, An, Sabin, Ca, Lundgren, Jd, Collaborators: Collins S, Data Collection on Adverse Events of Anti HIV Drugs Study G. r. o. u. p., Loeliger, E, Tressler, R, Weller, I, Worm, Sw, Sjøl, A, Sawitz, A, Rickenbach, M, Pezzotti, P, Krum, E, Gras, L, Balestre, E, Sundström, A, Poll, B, Fontas, E, Torres, F, Petoumenos, K, Kjaer, J, de Wolf, F, Zaheri, S, Bronsveld, W, Hillebrand Haverkort ME, Prins, Jm, Bos, Jc, Schattenkerk, Jk, Geerlings, Se, Godfried, Mh, Lange, Jm, van Leth FC, Lowe, Sh, van der Meer JT, Nellen, Fj, Pogány, K, van der Poll, T, Ruys, Ta, Sankatsing, Sr, van Twillert, G, van der Valk, M, van Vonderen MG, Vrouenraets, Sm, van Vugt, M, Wit, Fw, van Eeden, A, ten Veen JH, van Dam PS, Roos, Jc, Brinkman, K, Frissen, Ph, Weigel, Hm, Mulder, Jw, van Gorp EC, Meenhorst, Pl, Mairuhu, At, Veenstra, J, Danner, Sa, Van Agtmael MA, Claessen, Fa, Perenboom, Rm, Rijkeboer, A, van Vonderen, M, Richter, C, van der Berg, J, van Leusen, R, Vriesendorp, R, Jeurissen, Fj, Kauffmann, Rh, Koger, El, Bravenboer, B, ten Napel CH, Kootstra, Gj, Sprenger, Hg, Miesen, Wm, Doedens, R, Scholvinck, Eh, ten Kate RW, van Houte DP, Polee, M, Kroon, Fp, van den Broek, van Dissel JT, Schippers, Ef, Schreij, G, van de Geest, S, Verbon, A, Koopmans, Pp, Keuter, M, Post, F, van der Ven AJ, van der Ende ME, Gyssens, Ic, van der Feltz, M, den Hollander JG, de Marie, S, Nouwen, Jl, Rijnders, Bj, de Vries TE, Juttmann, Jr, van de Heul, C, van Kasteren ME, St Elisabeth SM, Bonten, Mj, Borleffs, Jc, Ellerbroek, Pm, Hoepelman, Im, Jaspers, Ca, Schouten, I, Schurink, Ca, Blok, Wl, Tanis, Aa, Groeneveld, Ph, Salamon, R, Beylot, J, Dupon, M, Le Bras, M, Pellegrin, Jl, Ragnaud, Jm, Dabis, F, Chêne, G, Jacqmin Gadda, H, Thiébaut, R, Lawson Ayayi, S, Lavignolle, V, Blaizeau, Mj, Decoin, M, Formaggio, Am, Delveaux, S, Labarerre, S, Uwamaliya, B, Vimard, E, Merchadou, L, Palmer, G, Touchard, D, Dutoit, D, Pereira, F, Boulant, B, Morlat, P, Bernard, N, Bonarek, M, Coadou, B, Gelie, P, Jaubert, D, Nouts, C, Lacoste, D, Dutronc, H, Cipriano, G, Lafarie, S, Chossat, I, Lacut, Jy, Leng, B, Mercié, P, Viallard, Jf, Faure, I, Rispal, P, Cipriano, C, Tchamgoué, S, Djossou, F, Malvy, D, Pivetaud, Jp, Chambon, D, De La Taille, C, Galperine, T, Neau, D, Ochoa, A, Beylot, C, Doutre, Ms, Bezian, Jh, Moreau, Jf, Taupin, Jl, Conri, C, Constans, J, Couzigou, P, Castera, L, Fleury, H, Lafon, Me, Masquelier, B, Pellegrin, I, Trimoulet, P, Moreau, F, Mestre, C, Series, C, Taytard, A, Glenday, K, Anderson, J, Cortissos, P, Mijch, A, Watson, K, Roth, N, Nicolson, J, Bloch, M, Agrawal, S, Franic, T, Baker, D, Vale, R, Carr, A, Cooper, D, Lacey, M, Hesse, K, Chuah, J, Lester, D, Fankhauser, W, Mallal, S, Forsdyke, C, Bulgannawar, S, Calvo, G, Mateu, S, Domingo, P, Sambeat, Ma, Gatell, J, Del Cacho, E, Cadafalch, J, Fuster, M, Codina, C, Sirera, G, Vaqué, A, Clumeck, N, Gerard, M, Kabeya, K, Konopnicki, D, Libois, A, Payen, Mc, Van Laethem, Y, Neaton, J, Bartsch, G, El Sadr WM, Thompson, G, Wentworth, D, Luskin Hawk, R, Telzak, E, Abrams, Di, Cohn, D, Markowitz, N, Arduino, R, Mushatt, D, Friedland, G, Perez, G, Tedaldi, E, Fisher, E, Gordin, F, Crane, Rl, Sampson, J, Baxter, J, Olsen, Ch, Mocroft, A, Vetter, N, Karpov, I, Vassilenko, A, Colebunders, R, Machala, L, Rozsypal, H, Sedlacek, D, Nielsen, J, Benfield, T, Gerstoft, J, Katzenstein, T, Hansen, Ab, Skinhøj, P, Pedersen, C, Zilmer, K, Katlama, C, Viard, Jp, Girard, Pm, Saint Marc, T, Vanhems, P, Dietrich, M, Manegold, C, van Lunzen, J, Stellbrink, Hj, Staszewski, S, Bieckel, M, Goebel, Fd, Fätkenheuer, C, Rockstroh, J, Schmidt, Re, Kosmidis, J, Gargalianos, P, Sambatakou, H, Perdios, J, Panos, G, Filandras, A, Banhegyi, D, Mulcahy, F, Yust, I, Burke, M, Turner, D, Pollack, S, Hassoun, J, Sthoeger, Z, Maayan, S, Vella, S, Chiesi, A, Arici, C, Pristerá, R, Mazzotta, F, Gabbuti, A, Esposito, R, Bedini, A, Chirianni, A, Montesarchio, E, Vullo, V, Santopadre, P, Narciso, P, Antinori, A, Franci, P, Zaccarelli, M, Lazzarin, A, Castagna, A, Viksna, L, Chaplinskas, S, Hemmer, R, Staub, T, Bruun, J, Maeland, A, Ormaasen, V, Knysz, B, Gasiorowski, J, Horban, A, Prokopowicz, D, Wiercinska Drapalo, A, Boron Kaczmarska, A, Pynka, M, Beniowski, M, Mularska, E, Trocha, H, Antunes, F, Mansinho, K, Maltez, F, Duiculescu, D, Babes, V, Streinu Cercel, A, Vinogradova, E, Rakhmanova, A, Jevtovic, D, Mokrás, M, Staneková, D, González Lahoz, J, Sanchez Conde, M, García Benayas, T, Martin Carbonero, L, Soriano, V, Clotet, B, Jou, A, Conejero, J, Ruiz, L, Tural, C, Gatell, Jm, Miró, Jm, Zamora, L, Blaxhult, A, Karlsson, A, Pehrson, P, Ledergerber, B, Francioli, P, Telenti, A, Hirschel, B, Soravia Dunand, V, Furrer, H, Kravchenko, E, Chentsova, N, Fisher, M, Brettle, R, Barton, S, Johnson, Am, Mercey, D, Murphy, M, Johnson, Ma, Weber, J, Scullard, G, Morfeldt, L, Thulin, G, Akerlund, B, Koppel, K, Flamholc, L, Håkangård, C, Ammassari, A, Maggiolo, F, Balotta, C, Bonfanti, P, Capobianchi, M, Ceccherini Silberstein, F, Cozzi Lepri, A, De Luca, A, Gervasoni, C, Girardi, E, Lo Caputo, S, Murri, R, Mussini, C, Puoti, M, Torti, Carlo, Moroni, M, Carosi, Giampiero, Cauda, R, Chiodo, F, Di Perri, G, Galli, M, Iardino, R, Ippolito, G, Panebianco, R, Pastore, G, Perno, Cf, Montroni, M, Scalise, G, Costantini, A, Riva, A, Tirelli, U, Martellotta, F, Ladisa, N, Suter, F, Colangeli, V, Fiorini, C, Carosi, G, Cristini, G, Torti, C, Minardi, C, Bertelli, D, Quirino, T, Manconi, Pe, Piano, P, Pizzigallo, E, D'Alessandro, M, Carnevale, G, Zoncada, A, Ghinelli, F, Sighinolfi, L, Leoncini, F, Pozzi, M, Grisorio, B, Ferrara, S, Pagano, G, Cassola, G, Alessandrini, A, Piscopo, R, Soscia, F, Tacconi, L, Orani, A, Perini, P, Tommasi, D, Congedo, P, Chiodera, F, Castelli, P, Rizzardini, G, Caggese, L, Galli, A, Merli, S, Pastecchia, C, Moioli, Mc, Gori, A, Cagni, S, Abrescia, N, Izzo, Cm, De Marco, M, Viglietti, R, Manzillo, E, Ferrari, C, Pizzaferri, P, Filice, G, Bruno, R, Magnani, G, Ursitti, Ma, Arlotti, M, Ortolani, P, Andreoni, M, Antonucci, G, Tozzi, V, Acinapura, R, De Longis, P, Trotta, Mp, Lichtner, M, Carletti, F, Mura, Mc, Mannazzu, M, Caramello, P, Orofino, Gc, Sciandra, M, Raise, E, Ebo, F, Pellizzer, G, Buonfrate, D, Caissotti, C, Dellamonica, P, Bentz, L, Bernard, E, De Salvador Guillouet, F, Durant, J, Mondain Miton, V, Perbost, I, Prouvost Keller, B, Pugliese, P, Rahelinirina, V, Roger, Pm, Vandenbos, F, Battegay, M, Bernasconi, E, Böni, J, Bucher, H, Bürgisser, P, Cattacin, S, Cavassini, M, Dubs, R, Egger, M, Elzi, L, Erb, P, Fischer, M, Flepp, M, Fontana, A, Furrer, Hj, Gorgievski, M, Günthard, H, Kaiser, L, Kind, C, Klimkait, T, Lauper, U, Opravil, M, Paccaud, F, Pantaleo, G, Perrin, L, Piffaretti, Jc, Schmid, Cr, Schüpbach, J, Speck, R, Trkola, A, Vernazza, P, and Yerly, S.
- Published
- 2008
8. Changes over time in risk factors for cardiovascular disease and use of lipid-lowering drugs in HIV-infected individuals and impact on myocardial infarction
- Author
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Data Collection on Adverse Events of Anti HIV Drugs Study Group, Sabin, Ca, d'Arminio Monforte, A, Friis Moller, N, Weber, R, El Sadr WM, Reiss, P, Kirk, O, Mercie, P, Law, Mg, De Wit, S, Pradier, C, Phillips, An, Collaborators: Lundgren JD, Lundgren J. D., Collins, S, Loeliger, E, Tressler, R, Weller, I, Friis Møller, N, Worm, Sw, Sjøl, A, Sawitz, A, Rickenbach, M, Pezzotti, P, Krum, E, Gras, L, Balestre, E, Sundström, A, Poll, B, Fontas, E, Torres, F, Petoumenos, K, Kjaer, J, de Wolf, F, Zaheri, S, Bronsveld, W, Hillebrand Haverkort ME, Prins, Jm, Bos, Jc, Eeftinck Schattenkerk JK, Geerlings, Se, Godfried, Mh, Lange, Jm, van Leth FC, Lowe, Sh, van der Meer JT, Nellen, Fj, Pogány, K, van der Poll, T, Ruys, Ta, Sankatsing, S, Steingrover, R, van Twillert, G, van der Valk, M, van Vonderen MG, Vrouenraets, Sm, van Vugt, M, Wit, Fw, van Eeden, A, ten Veen JH, van Dam PS, Roos, Jc, Brinkman, K, Frissen, Ph, Weigel, Hm, Mulder, Jw, van Gorp EC, Meenhorst, Pl, Mairuhu, At, Veenstra, J, Danner, Sa, Van Agtmael MA, Claessen, Fa, Perenboom, Rm, Rijkeboer, A, van Vonderen, M, Richter, C, van der Berg, J, van Leusen, R, Vriesendorp, R, Jeurissen, Fj, Kauffmann, Rh, Koger, El, Bravenboer, B, ten Napel CH, Kootstra, Gj, Sprenger, Hg, Miesen, Wm, Doedens, R, Scholvinck, Eh, ten Kate RW, van Houte DP, Polee, M, Kroon, Fp, van den Broek PJ, van Dissel JT, Schippers, Ej, Schreij, G, van de Geest PJ, Verbon, A, Koopmans, Pp, Keuter, M, Post, F, van der Ven AJ, van der Ende ME, Gyssens, Ic, van der Feltz, M, den Hollander JG, de Marie, S, Nouwen, Jl, Rijnders, Bj, de Vries TE, Juttmann, Jr, van de Heul, C, van Kasteren ME, Elisabeth, S, Schneider, Mm, Bonten, Mj, Borleffs, Jc, Ellerbroek, Pm, Hoepelman, Im, Jaspers, Ca, Schouten, I, Schurink, Ca, Blok, Wl, Tanis, Aa, Groeneveld, Ph, Salamon, R, Beylot, J, Dupon, M, Le Bras, M, Pellegrin, Jl, Ragnaud, Jm, Dabis, F, Chêne, G, Jacqmin Gadda, H, Thiébaut, R, Lawson Ayayi, S, Lavignolle, V, Blaizeau, Mj, Decoin, M, Formaggio, Am, Delveaux, S, Labarerre, S, Uwamaliya, B, Vimard, E, Merchadou, L, Palmer, G, Touchard, D, Dutoit, D, Pereira, F, Boulant, B, Morlat, P, Bernard, N, Bonarek, M, Bonnet, F, Coadou, B, Gelie, P, Jaubert, D, Nouts, C, Lacoste, D, Dutronc, H, Cipriano, G, Lafarie, S, Chossat, I, Lacut, Jy, Leng, B, Mercié, P, Viallard, Jf, Faure, I, Rispal, P, Cipriano, C, Tchamgoué, S, Djossou, F, Malvy, D, Pivetaud, Jp, Chambon, D, De La Taille, C, Galperine, T, Neau, D, Ochoa, A, Beylot, C, Doutre, Ms, Bezian, Jh, Moreau, Jf, Taupin, Jl, Conri, C, Constans, J, Couzigou, P, Castera, L, Fleury, H, Lafon, Me, Masquelier, B, Pellegrin, I, Trimoulet, P, Moreau, F, Mestre, C, Series, C, Taytard, A, Law, M, Anderson, J, Lowe, K, Mijch, A, Watson, K, Roth, N, Wood, H, Bloch, M, Gowers, A, Baker, D, Mcfarlane, R, Carr, A, Cooper, D, Chuah, J, Fankhauser, W, Mallal, S, Skett, J, Calvo, G, Mateu, S, Domingo, P, Sambeat, Ma, Gatell, J, Del Cacho, E, Cadafalch, J, Fuster, M, Codina, C, Sirera, G, Vaqué, A, Clumeck, N, Gerard, M, Kabeya, K, Konopnicki, D, Libois, A, Payen, Mc, Van Laethem, Y, Neaton, J, Thompson, G, Wentworth, D, Luskin Hawk, R, Telzak, E, Abrams, Di, Cohn, D, Markowitz, M, Crane, Lr, Arduino, R, Mushatt, D, Friedland, G, Perez, G, Tedaldi, E, Fisher, E, Gordin, F, Sampson, J, Baxter, J, Olsen, Ch, Mocroft, A, Lundgren, Jd, Vetter, N, Karpov, I, Vassilenko, A, Colebunders, R, Machala, L, Rozsypal, H, Sedlacek, D, Nielsen, J, Benfield, T, Gerstoft, J, Katzenstein, T, Hansen, Ab, Skinhøj, P, Pedersen, C, Zilmer, K, Katlama, C, Viard, Jp, Girard, Pm, Saint Marc, T, Vanhems, P, Dabis, C, Dietrich, M, Manegold, C, van Lunzen, J, Stellbrink, Hj, Staszewski, S, Bieckel, M, Goebel, Fd, Fätkenheuer, G, Rockstroh, J, Schmidt, Re, Kosmidis, J, Gargalianos, P, Sambatakou, H, Perdios, J, Panos, G, Filandras, A, Banhegyi, D, Mulcahy, F, Yust, I, Burke, M, Turner, D, Pollack, S, Hassoun, J, Sthoeger, Z, Maayan, S, Vella, S, Chiesi, A, Arici, C, Pristerá, R, Mazzotta, F, Gabbuti, A, Esposito, R, Bedini, A, Chirianni, A, Montesarchio, E, Vullo, V, Santopadre, P, Narciso, P, Antinori, A, Franci, P, Zaccarelli, M, Lazzarin, A, Castagna, A, D'Arminio Monforte, A, Viksna, L, Chaplinskas, S, Hemmer, R, Staub, T, Bruun, J, Maeland, A, Ormaasen, V, Knysz, B, Gasiorowski, J, Horban, A, Prokopowicz, D, Wiercinska Drapalo, A, Boron Kaczmarska, A, Pynka, M, Beniowski, M, Mularska, E, Trocha, H, Antunes, F, Mansinho, K, Maltez, F, Duiculescu, D, Babes, V, Streinu Cercel, A, Vinogradova, E, Rakhmanova, A, Jevtovic, D, Mokrás, M, Staneková, D, González Lahoz, J, Sanchez Conde, M, García Benayas, T, Martin Carbonero, L, Soriano, V, Clotet, B, Jou, A, Conejero, J, Ruiz, L, Tural, C, Gatell, Jm, Miró, Jm, Zamora, L, Blaxhult, A, Karlsson, A, Pehrson, P, Ledergerber, B, Francioli, P, Telenti, A, Hirschel, B, Soravia Dunand, V, Furrer, H, Kravchenko, E, Chentsova, N, Fisher, M, Brettle, R, Barton, S, Johnson, Am, Mercey, D, Murphy, M, Johnson, Ma, Weber, J, Scullard, G, Morfeldt, L, Thulin, G, Akerlund, B, Koppel, K, Flamholc, L, Håkangård, C, Moroni, M, Cargnel, A, Merli, S, Rizzardini, G, Pastecchia, C, Caggese, L, Moioli, C, Mura, Ms, Mannazzu, M, Suter, F, Manconi, Pe, Piano, P, Lo Caputo, S, Poggiom, A, Bottari, G, Pagano, G, Alessandrini, A, Scasso, A, Vincenti, A, Abbadessa, V, Mancuso, S, Alberici, F, Ruggieri, A, Arlotti, M, Ortolani, P, De Lalla, F, Tositti, G, Cassola, G, Piscopo, R, Raise, E, Ebo, F, Soscia, F, Tacconi, L, Tirelli, U, Di Gennaro, G, Santoro, D, Pusterla, L, Carosi, Giampiero, Torti, Carlo, Cadeo, G, Bertelli, D, Carnevale, G, Galloni, D, Filice, G, Bruno, R, Di Perri, G, Arnaudo, I, Caramello, P, Orofino, Gc, Soranzo, Ml, Bonasso, M, Quirino, T, Melzi, S, Chiodo, F, Colangeli, V, Magnani, G, Ursitti, M, Menichetti, F, Martinelli, C, Mussini, C, Ghinelli, F, Sighinolfi, L, Coronado, O, Ballardini, G, Rizzo, E, Montroni, M, Braschi, Mc, Petrelli, E, Cioppi, A, Cauda, R, De Luca, A, Petrosillo, N, Noto, P, Bontempo, G, Acinapura, A, Antonucci, G, De Longis, P, Lichtner, M, Pastore, G, Ladisa, N, Viglietti, R, Piazza, M, Nappa, S, Abrescia, N, De Marco, M, Colomba, A, Prestileo, T, De Stefano, C, La Gala, A, Cosco, L, Scerbo, A, Grima, P, Tundo, P, Vecchiet, J, D'Alessandro, M, Grisorio, B, Ferrara, S, Caissotti, C, Dellamonica, P, Bentz, L, Bernard, E, De Salvador Guillouet, F, Durant, J, Mondain Miton, V, Perbost, I, Prouvost Keller, B, Pugliese, P, Rahelinirina, V, Roger, Pm, Vandenbos, F, Battegay, M, Bernasconi, E, Böni, J, Bucher, H, Bürgisser, P, Cattacin, S, Cavassini, M, Dubs, R, Egger, M, Elzi, L, Erb, P, Fischer, M, Flepp, M, Fontana, A, Furrer, Hj, Gorgievski, M, Günthard, H, Kaiser, L, Kind, C, Klimkait, T, Lauper, U, Opravil, M, Paccaud, F, Pantaleo, G, Perrin, L, Piffaretti, Jc, Rudin, C, Schmid, P, Schüpbach, J, Speck, R, Trkola, A, Vernazza, P, and Yerly, S.
- Published
- 2008
9. Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients enrolled in the D:A:D study: a multi-cohort collaboration
- Author
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D:A:D Study Group, Sabin, Ca, Worm, Sw, Weber, R, Reiss, P, El Sadr, W, Dabis, F, De Wit, S, Law, M, D'Arminio Monforte, A, Friis Møller, N, Kirk, O, Pradier, C, Weller, I, Phillips, An, Collaborators: Collins S, Lundgren J. D., El Sadr WM, Phillips, A, Rosseau, F, Storfer, Sp, Weber, I, Lundgren, Jd, Sjøl, A, Sawitz, A, Rickenbach, M, Pezzotti, P, Krum, E, Gras, L, Balestre, E, Sundström, A, Poll, B, Fontas, E, Torres, F, Petoumenos, K, Kjaer, J, Hammer, S, Neaton, J, de Wolf, F, Zaheri, S, Bronsveld, W, Hillebrand Haverkort ME, Prins, Jm, Bos, Jc, Eeftinck Schattenkerk JK, Geerlings, Se, Godfried, Mh, Lange, Jm, van Leth FC, Lowe, Sh, van der Meer JT, Nellen, Fj, Pogány, K, van der Poll, T, Ruys, Ta, Sankatsing, Steingrover, R, van Twillert, G, van der Valk, M, van Vonderen MG, Vrouenraets, Sm, van Vugt, M, Wit, Fw, van Eeden, A, ten Veen JH, van Dam PS, Roos, Jc, Brinkman, K, Frissen, Ph, Weigel, Hm, Mulder, Jw, van Gorp EC, Meenhorst, Pl, Mairuhu, At, Veenstra, J, Danner, Sa, Van Agtmael MA, Claessen, Fa, Perenboom, Rm, Rijkeboer, A, van Vonderen, M, Richter, C, van der Berg, J, van Leusen, R, Vriesendorp, R, Jeurissen, Fj, Kauffmann, Rh, Koger, El, Bravenboer, B, ten Napel CH, Kootstra, Gj, Sprenger, Hg, Miesen, Wm, Doedens, R, Scholvinck, Eh, ten Kate RW, van Houte DP, Polee, M, Kroon, Fp, van den Broek, van Dissel JT, Schippers, Ef, Schreij, G, van de Geest, S, Verbon, A, Koopmans, Pp, Keuter, M, Post, F, van der Ven AJ, van der Ende ME, Gyssens, Ic, van der Feltz, M, den Hollander JG, de Marie, S, Nouwen, Jl, Rijnders, Bj, de Vries TE, Juttmann, Jr, van de Heul, C, van Kasteren ME, Elisabeth, St, Schneider, Mm, Bonten, Mj, Borleffs, Jc, Ellerbroek, Pm, Hoepelman, Im, Jaspers, Ca, Schouten, I, Schurink, Ca, Blok, Wl, Tanis, Aa, Groeneveld, Ph, Salamon, R, Beylot, J, Dupon, M, Le Bras, M, Pellegrin, Jl, Ragnaud, Jm, Chêne, G, Jacqmin Gadda, H, Thiébaut, R, Lawson Ayayi, S, Lavignolle, V, Blaizeau, Mj, Decoin, M, Formaggio, Am, Delveaux, S, Labarerre, S, Uwamaliya, B, Vimard, E, Merchadou, L, Palmer, G, Touchard, D, Dutoit, D, Pereira, F, Boulant, B, Morlat, P, Bernard, N, Bonarek, M, Bonnet, F, Coadou, B, Gelie, P, Jaubert, D, Nouts, C, Lacoste, D, Dutronc, H, Cipriano, G, Lafarie, S, Chossat, I, Lacut, Jy, Leng, B, Mercié, P, Viallard, Jf, Faure, I, Rispal, P, Cipriano, C, Tchamgoué, S, Djossou, F, Malvy, D, Pivetaud, Jp, Chambon, D, De La Taille, C, Galperine, T, Neau, D, Ochoa, A, Beylot, C, Doutre, Ms, Bezian, Jh, Moreau, Jf, Taupin, Jl, Conri, C, Constans, J, Couzigou, P, Castera, L, Fleury, H, Lafon, Me, Masquelier, B, Pellegrin, I, Trimoulet, P, Moreau, F, Mestre, C, Series, C, Taytard, A, Anderson, J, Cortossis, P, Hoy, J, Watson, K, Roth, N, Bloch, M, Franic, T, Baker, D, Mcfarlane, R, Carr, A, Cooper, D, Chuah, J, Fankhauser, W, Mallal, S, Forsdyke, C, Calvo, G, Mateu, S, Domingo, P, Sambeat, Ma, Gatel, J, Del Cacho, E, Cadafalch, J, Fuster, M, Codina, C, Sirera, G, Vaqué, A, Clumeck, N, Gerard, M, Kabeya, K, Konopnicki, D, Libois, A, Payen, Mc, Van Laethem, Y, Bartsch, G, Thompson, G, Wentworth, D, Luskin Hawk, R, Telzak, E, Abrams, Di, Cohn, D, Markowitz, N, Arduino, R, Mushatt, D, Friedland, G, Perez, G, Tedaldi, E, Fisher, E, Gordin, F, Crane, Lr, Sampson, J, Baxter, J, Mocroft, A, Vetter, N, Karpov, I, Vassilenko, A, Colebunders, R, Machala, L, Rozsypal, H, Sedlacek, D, Nielsen, J, Benfield, T, Gerstoft, J, Katzenstein, T, Hansen, Ab, Skinhøj, P, Pedersen, C, Zilmer, K, Katlama, C, Viard, Jp, Girard, Pm, Saint Marc, T, Vanhems, P, Dietrich, M, Manegold, C, van Lunzen, J, Stellbrink, Hj, Staszewski, S, Bieckel, M, Goebel, Fd, Fätkenheuer, G, Rockstroh, J, Schmidt, Re, Kosmidis, J, Gargalianos, P, Sambatakou, H, Perdios, J, Panos, G, Filandras, A, Banhegyi, D, Mulcahy, F, Yust, I, Burke, M, Turner, D, Pollack, S, Hassoun, J, Sthoeger, Z, Maayan, S, Vella, S, Chiesi, A, Arici, C, Pristerá, R, Mazzotta, F, Gabbuti, A, Esposito, R, Bedini, A, Chirianni, A, Montesarchio, E, Vullo, V, Santopadre, P, Narciso, P, Antinori, A, Franci, P, Zaccarelli, M, Lazzarin, A, Castagna, A, Viksna, L, Chaplinskas, S, Hemmer, R, Staub, T, Bruun, J, Maeland, A, Ormaasen, V, Knysz, B, Gasiorowski, J, Horban, A, Prokopowicz, D, Wiercinska Drapalo, A, Boron Kaczmarsk, A, Pynka, M, Beniowski, M, Mularska, E, Trocha, H, Antunes, A, Mansinho, K, Maltez, F, Duiculescu, D, Streinu Cercel, A, Vinogradova, E, Rakhmanova, A, Jevtovic, D, Mokrás, M, Staneková, D, González Lahoz, J, Sanchez Conde, M, García Benayas, T, Martin Carbonero, L, Soriano, V, Clotet, B, Jou, A, Conejero, J, Ruiz, L, Tural, C, Gatell, Jm, Miró, Jm, Zamora, L, Gutierrez, M, Mateo, G, Blaxhult, A, Karlsson, A, Pehrson, P, Ledergerber, B, Francioli, P, Telenti, A, Hirschel, B, Soravia Dunand, V, Furrer, H, Kravchenko, E, Chentsova, N, Fisher, M, Brettle, R, Barton, S, Johnson, Am, Mercey, D, Murphy, M, Johnson, Ma, Weber, J, Scullard, G, Morfeld, L, Thulin, G, Akerlund, B, Koppel, K, Flamholc, L, Håkangård, C, d'Arminio Monforte, A, Moroni, M, Cargnel, A, Merli, S, Vigevani, Gm, Pastecchia, C, Morsica, G, Caggese, L, Moioli, C, Mura, Ms, Mannazzu, M, Suter, F, Manconi, Pe, Piano, P, Lo Caputo, S, Poggio, A, Bottari, G, Pagano, G, Alessandrini, A, Scasso, A, Abbadessa, V, Mancuso, S, Alberici, F, Ruggieri, A, Arlotti, M, Ortolani, P, De Lalla, F, Tositti, G, Cassola, G, Piscopo, R, Raise, E, Ebo, F, Soscia, F, Tacconi, L, Tirelli, U, Cinelli, R, Santoro, D, Pusterla, L, Carosi, Giampiero, Torti, Carlo, Cadeo, G, Bertelli, D, Carnevale, G, Citterio, P, Filice, G, Bruno, R, Di Perri, G, Arnaudo, I, Caramello, P, Orofino, Gc, Soranzo, Ml, Bonasso, M, Rizzardini, G, Melzi, S, Chiodo, F, Colangeli, V, Magnani, G, Ursitti, M, Menichetti, F, Martinelli, C, Mussini, C, Ghinelli, F, Sighinolfi, L, Coronado, O, Ballardini, G, Rizzo, E, Montroni, M, Braschi, Mc, Petrelli, E, Cioppi, A, Cauda, R, De Luca, A, Petrosillo, N, Noto, P, Bontempo, G, Acinapura, R, Antonucci, G, De Longis, P, Lichtner, M, Pastore, G, Ladisa, N, Viglietti, R, Piazza, M, Nappa, S, Abrescia, N, De Marco, M, Colomba, A, Prestileo, T, De Stefano, C, La Gala, A, Cosco, L, Scerbo, A, Grima, P, Tundo, P, Vecchiet, J, D'Alessandro, M, Grisorio, B, Ferrara, S, Caissotti, C, Dellamonica, P, Bentz, L, Bernard, E, De Salvador Guillouet, F, Durant, J, Mondain Miton, V, Perbost, I, Prouvost Keller, B, Pugliese, P, Rahelinirina, V, Roger, Pm, Vander, F, Battegay, M, Bernasconi, E, Böni, J, Buche, H, Bürgisser, P, Cattacin, S, Cavassini, M, Dubs, R, Egger, M, Elzi, L, Erb, P, Fischer, M, Flepp, M, Fontana, A, Furrer, Hj, Gorgievski, M, Günthard, H, Kaiser, L, Kind, C, Klimkait, T, Lauper, U, Opravil, M, Paccaud, F, Pantaleo, G, Perrin, L, Piffaretti, Jc, Rudin, C, Schmid, P, Schüpbach, J, Speck, R, Trkola, A, Vernazza, P, and Yerly, S.
- Published
- 2008
10. Incidence of tuberculosis among HIV-infected patients receiving highly active antiretroviral therapy in Europe and North America
- Author
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Costagliola, D, Dabis, F, Monforte, AD, de Wolf, F, Egger, M, Fatkenheuer, G, Gill, J, Hogg, R, Justice, A, Ledergerber, B, Lundgren, J, May, M, Phillips, A, Reiss, P, Sabin, C, Staszewski, S, Sterne, J, Weller, H.H., Beckthold, B, Yip, B, Dauer, B, Fusco, J, Grabar, S, Lanoy, E, Junghans, C, Lavignolle, V., van Leth, F, Pereira, E, Pezzotti, P, Schmeisser, N, Billaud, E, Boue, F, Duval, J., Duvivier, C, Enel, P, Fournier, S, Gasnault, J, Gaud, C, Gilquin, J, Khuong, MA, Lang, JM, Mary-Krause, M, Sprenger, HG, Doedens, Rienus, Scholvinck, EH, and Borleffs, JCC
- Subjects
RISK ,AIDS ,INITIATION ,RECONSTITUTION ,OPPORTUNISTIC INFECTIONS ,IMMUNE-RESPONSES ,EPIDEMIC ,IMPACT ,COHORT ,IMMUNOLOGICAL RESPONSE - Abstract
Background. We obtained estimates of the incidence of tuberculosis (TB) among patients receiving HAART and identified determinants of the incidence. Methods. We analyzed the incidence of TB during the first 3 years after initiation of HAART among 17,142 treatment-naive, AIDS- free persons starting HAART who were enrolled in 12 cohorts from Europe and North America. We used univariable and multivariable Poisson regression models to identify factors associated with the incidence. Results. During the first 3 years (36,906 person-years), 173 patients developed TB (incidence, 4.69 cases per 1000 person-years). In multivariable analysis, the incidence rate was lower for men who have sex with men, compared with injection drug users (relative rate, 2.46; 95% confidence interval [CI], 1.51-4.01), heterosexuals (relative rate, 2.42; 95% CI, 1.64-3.59), those with other suspected modes of transmission (relative rate, 1.66; 95% CI, 0.91-3.06), and those with a higher CD4(+) count at the time of HAART initiation (relative rate per log(2) cells/mL, 0.87; 95% CI, 0.84-0.91). During 28,846 person-years of follow-up after the first 6 months of HAART, 88 patients developed TB (incidence, 3.1 cases per 1000 person-years of follow-up). In multivariable analyses, a low baseline CD4(+) count (relative rate per log(2) cells/mL, 0.89; 95% CI, 0.83-0.96), 6-month CD4(+) count (relative rate per log(2) cells/mL, 0.90; 95% CI, 0.81-0.99), and a 6-month HIV RNA level 1400 copies/mL (relative rate, 2.21; 95% CI, 1.33-3.67) were significantly associated with the risk of acquiring TB after 6 months of HAART. Conclusion. The level of immunodeficiency at which HAART is initiated and the response to HAART are important determinants of the risk of TB. However, this risk remains appreciable even among those with a good response to HAART, suggesting that other interventions may be needed to control the TB epidemic in the HIV-infected population.
- Published
- 2005
11. Quantitation of HIV-1 RNA in dried blood and plasma spots
- Author
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Reigadas, S., Schrive, M.H., Aurillac-Lavignolle, V., and Fleury, H.J.
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- 2009
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12. The use of the Framingham equation to predict myocardial infarctions in HIV-infected patients: Comparison with observed events in the D:A:D Study
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Law, Mathew M.G., Friis-Møller, Nina, Lundgren, Jens D, El-Sadr, Wafaa, Weber, Rainer, Reiss, Peter, d'Arminio Monforte, Antonella, Thiebaut, Rodolphe, Morfeldt, Linda, De Wit, Stéphane, Pradier, Christian, Calvo, Gonzalo, Kirk, Ole, Sabin, Caroline, Phillips, AN, Collins, Simon, Mertenskoetter, E., Loeliger, R., Tressler, Randall, Weller, Ian, Sawitz, Allen, Rickenbach, Martin, Pezzotti, Patrizio, Krum, Eric, Gras, Luuk, Lavignolle, V., Sundströrm, A., Poll, Bénédicte, Fontas, Eric, Torres, Ferrán, Petoumenos, Kathy, Kjaer, Jesper, Law, Mathew M.G., Friis-Møller, Nina, Lundgren, Jens D, El-Sadr, Wafaa, Weber, Rainer, Reiss, Peter, d'Arminio Monforte, Antonella, Thiebaut, Rodolphe, Morfeldt, Linda, De Wit, Stéphane, Pradier, Christian, Calvo, Gonzalo, Kirk, Ole, Sabin, Caroline, Phillips, AN, Collins, Simon, Mertenskoetter, E., Loeliger, R., Tressler, Randall, Weller, Ian, Sawitz, Allen, Rickenbach, Martin, Pezzotti, Patrizio, Krum, Eric, Gras, Luuk, Lavignolle, V., Sundströrm, A., Poll, Bénédicte, Fontas, Eric, Torres, Ferrán, Petoumenos, Kathy, and Kjaer, Jesper
- Abstract
Background: The D:A:D (Data Collection on Adverse Events of Anti-HIV Drugs) Study, a prospective observational study on a cohort of 23 468 patients with HIV infection, indicated that the incidence of myocardial infarction (MI) increased by 26% per year of exposure to combination antiretroviral treatment (CART). However, it remains unclear whether the observed increase in the rate of MI in this population can be attributed to changes in conventional cardiovascular risk factors. Objectives: To compare the number of MIs observed among participants in the D:A:D Study with the number predicted by assuming that conventional cardiovascular risk equations apply to patients with HIV infection. Methods: The Framingham equation, a conventional cardiovascular risk algorithm, was applied to individual patient data in the D:A:D Study to predict rates of MI by duration of CART. A series of sensitivity analyses were performed to assess the effect of model and data assumptions. Predictions were extrapolated to provide 10-year risk estimates, and various scenarios were modelled to assess the expected effect of different interventions. Results: In patients receiving CART, the observed numbers of MIs during D:A:D follow up were similar to or somewhat higher than predicted numbers: 9 observed vs 5.5 events predicted, 14 vs 9.8, 22 vs 14.9, 31 vs 23.2 and 47 vs 37.0 for <1 year, 1-2 years, 2-3 years, 3-4 years and >4-years CART exposure, respectively. In patients who had not received CART, the observed number of MIs was fewer than predicted (3 observed vs 7.6 predicted). Nine percent of the study population have a predicted 10-year risk of MI above 10%, a level usually associated with initiation of intervention on risk factors. Conclusions: A consistent feature of all analyses was that observed and predicted rates of MI increased in a parallel fashion with increased CART duration, suggesting that the observed increase in risk of MI may at least in part be explained by CART-induced change, SCOPUS: ar.j, FLWIN, info:eu-repo/semantics/published
- Published
- 2006
13. Homocystéine, anticorps anti-MDA-LDL modifiéset mesure de l'épaisseur intima-média carotidienne chez les patients VIH+
- Author
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Mercié, P., primary, Lavignolle, V., additional, Thiébaut, R., additional, Laporte, F., additional, Bellet, H., additional, Malvy, D., additional, Morlat, P., additional, Ragnaud, J.M., additional, Dupon, M., additional, Pellegrin, J.L., additional, and Dabis, F., additional
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- 2001
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14. Augmentation de l'épaisseur intima-média carotidienne chez les patients VIH+:étude longitudinale sur 12 mois
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Mercié, P., primary, Lavignolle, V., additional, Thiébaut, R., additional, Pellegrin, J.L., additional, Yvorra-Vives, M.C., additional, Cipriano, C., additional, Morlat, P., additional, Ragnaud, J.M., additional, Dupon, M., additional, Malvy, D., additional, Lawson-Ayayi, S., additional, Roudaut, R., additional, and Dabis, F., additional
- Published
- 2001
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15. Mesure de l'épaisseur intima-média carotidienne, marqueur du risque d'athérosclérose, chez les patients infectés par le VIH-1
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Mercié, P., primary, Thiébaut, R., additional, Lavignolle, V., additional, Pellegrin, J.L., additional, Yvorra-Vives, M.C., additional, Morlat, P., additional, Ragnaud, J.M., additional, Dupon, M., additional, Malvy, D., additional, Bellet, H., additional, Lawson-Ayayi, S., additional, Roudaut, R., additional, and Dabis, F., additional
- Published
- 2001
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16. Flow cytometry detection of caspase 3 activation in preapoptotic leukemic cells
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Belloc, F., primary, Belaud-Rotureau, M.A., additional, Lavignolle, V., additional, Bascans, E., additional, Braz-Pereira, E., additional, Durrieu, F., additional, and Lacombe, F., additional
- Published
- 2000
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17. Carotid intima–media thickness is slightly increased over time in HIV-1-infected patients.
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Merci, P., Thi&ébaut, R., Aurillac-Lavignolle, V., Pellegrin, J. L., Yvorra-Vives, M. C., Cipriano, C., Neau, D., Morlat, P., Ragnaud, J. M., Dupon, M., Bonnet, F., Lawson-Ayayi, S., Malvy, D., Roudaut, R., and Dabis, F.
- Subjects
HIV-positive persons ,HIV infections ,ATHEROSCLEROSIS ,BLOOD vessels ,CARDIOVASCULAR diseases - Abstract
Objectives HIV-infected patients are at risk of atherosclerosis and cardiovascular diseases. In a 12-month follow-up study, we aimed to investigate changes in carotid intima–media thickness (IMT), a surrogate marker of atherosclerosis, and its determinants in HIV-1-infected patients. Methods Our multicentre prospective longitudinal cohort study included 346 HIV-infected patients, for each of whom two IMT measurements were taken by B-mode ultrasonography at baseline (M0) and 1 year later (M12). Results We observed a significant but moderate increase in the common carotid artery (CCA) median IMT, from 0.54 to 0.56 mm ( P<10
−4 ), i.e. an increase of 0.020 mm (95% confidence interval 0.012–0.029). There was a significant association between cross-sectional CCA IMT measures at M12 and conventional cardiovascular risk factors (higher CCA IMT with older age, P<10−4 ; male gender, P=0.02; tobacco consumption, P=0.05), as well as higher CD4 cell count at M12 (>median 455 cells/μL, P=0.01). Only CD4 cell count at M0 was strongly and positively associated with the variation in IMT between M0 and M12 ( P=4 × 10−3 ). IMT progression was +0.0020 mm for the lowest quartile of CD4 cell count distribution at M0, i.e. 3–253 cells/μL, +0.010 mm for 253–402 cells/μL, +0.043 mm for 402–590 cells/μL, and +0.028 mm for 590–2270 cells/μL. No association was found with type or duration of antiretroviral exposure. Conclusions Conventional cardiovascular risk factors are major determinants of IMT evolution. The link between immunological status and carotid IMT requires further study. [ABSTRACT FROM AUTHOR]- Published
- 2005
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18. Incidence of tuberculosis among HIV-infected patients receiving highly active antiretroviral therapy in Europe and North America
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Costagliola, D., Dabis, F., Monforte, Ad, Wolf, F., Egger, M., Fatkenheuer, G., Gill, J., Hogg, R., Justice, A., Ledergerber, B., Lundgren, J., May, M., Phillips, A., Reiss, P., Sabin, C., Staszewski, S., Sterne, J., Weller, I., Beckthold, B., Yip, B., Dauer, B., Fusco, J., Grabar, S., Lanoy, E., Junghans, C., Lavignolle, V., Leth, F., Pereira, E., Pezzotti, P., Schmeisser, N., Billaud, E., Boue, F., Duval, X., Duvivier, C., Enel, P., Fournier, S., Gasnault, J., Gaud, C., Gilquin, J., Khuong, Ma, Lang, Jm, Mary-Krause, M., Matheron, S., Meyohas, Mc, Pialoux, G., Poizot-Martin, I., Pradier, C., Rouveix, E., Salmon-Ceron, D., Sobel, A., Tattevin, P., Tissot-Dupont, H., Yasdanpanah, Y., Aronica, E., Tirard-Fleury, V., Tortay, I., Abgrall, S., Guiguet, M., Leneman, H., Lievre, L., Potard, V., Saidi, S., Vilde, Jl, Leport, C., Yeni, P., Bouvet, E., Gaudebout, C., Crickx, B., Picard-Dahan, C., Weiss, L., Tisne-Dessus, D., Sicard, D., Salmon, D., Auperin, I., Viard, Jp, Roudiere, L., Delfraissy, Jf, Goujard, C., Lesprit, P., Jung, C., Meynard, Jl, Picard, O., Desplanque, N., Cadranel, J., Mayaud, C., Rozenbaum, W., Bricaire, F., Katlama, C., Herson, S., Simon, A., Decazes, Jm, Molina, Jm, Clauvel, Jp, Gerard, L., Widal, Ghlf, Sellier, P., Diemer, M., Dupont, C., Berthe, H., Saiag, P., Mortier, L., Mortier, E., Chandemerle, C., Truchis, P., Bentata, M., Honore, P., Tassi, S., Jeantils, V., Mechali, D., Taverne, B., Laurichesse, H., Gourdon, F., Lucht, F., Fresard, A., Faller, Jp, Eglinger, P., Bazin, C., Verdon, R., Peyramond, D., Boibieux, A., Touraine, Jl, Livrozet, Jm, Trepo, C., Cotte, L., Ravaux, I., Delmont, Jp, Moreau, J., Gastaut, Ja, Soubeyrand, J., Retornaz, F., Blanc, Pa, Allegre, T., Galinier, A., Ruiz, Jm, Lepeu, G., Granet-Brunello, P., Pelissier, L., Esterni, Jp, Nezri, M., Cohen-Valensi, R., Laffeuillade, A., Chadapaud, S., Reynes, J., May, T., Rabaud, C., Raffi, F., Pugliese, P., Michelet, C., Arvieux, C., Caron, F., Borsa-Lebas, F., Fraisse, P., Massip, P., Cuzin, L., Arlet-Suau, E., Legrand, Mft, Sobesky, M., Pradinaud, R., Guyon, F., Contant, M., Montroni, M., Scalise, G., Braschi, Mc, Aviano, Ar, Tirelli, U., Cinelli, R., Pastore, G., Ladisa, N., Minafra, G., Suter, F., Arici, C., Chiodo, F., Colangeli, V., Fiorini, C., Coronado, O., Carosi, G., Cadeo, Gp, Torti, C., Minardi, C., Bertelli, D., Rizzardini, G., Melzi, S., Manconi, Pe, Catanzaro, Pp, Cosco, L., Scerbo, A., Vecchiet, J., D Alessandro, M., Santoro, D., Pusterla, L., Carnevale, G., Citterio, P., Vigano, P., Mena, M., Ghinelli, F., Sighinolfi, L., Leoncini, F., Mazzotta, F., Pozzi, M., Lo Caputo, S., Angarano, G., Grisorio, B., Saracino, A., Ferrara, S., Grima, P., Tundo, P., Pagano, G., Cassola, G., Alessandrini, A., Piscopo, R., Toti, M., Chigiotti, S., Soscia, F., Tacconi, L., Orani, A., Perini, P., Scasso, A., Vincenti, A., Chiodera, F., Castelli, P., Scalzini, A., Palvarini, L., Moroni, M., Lazzarin, A., Cargnel, A., Vigevani, Gm, Caggese, L., Repetto, D., Galli, A., Merli, S., Pastecchia, C., Moioli, Mc, Esposito, R., Mussini, C., Abrescia, N., Chirianni, A., Izzo, Cm, Piazza, M., Marco, M., Viglietti, R., Manzillo, E., Nappa, S., Colomba, A., Abbadessa, V., Prestileo, T., Mancuso, S., Ferrari, C., Pizzaferri, P., Filice, G., Minoli, L., Bruno, R., Novati, S., Baldelli, F., Tinca, M., Petrelli, E., Cioppi, A., Alberici, F., Ruggieri, A., Menichetti, F., Martinelli, C., Stefano, C., La Gala, A., Ballardini, G., Rizzo, E., Magnani, G., Ursitti, Ma, Arlotti, M., Ortolani, P., Cauda, R., Dianzani, F., Ippolito, G., Antinori, A., Antonucci, G., D Elia, S., Narciso, P., Petrosillo, N., Vullo, V., Luca, A., Bacarelli, A., Zaccarelli, M., Acinapura, R., Longis, P., Brandi, A., Trotta, Mp, Noto, P., Lichtner, M., Capobianchi, MR, Carletti, F., Girardi, E., Rezza, G., Mura, Ms, Mannazzu, M., Caramello, P., Di Perri, G., Soranzo, Ml, Orofino, Gc, Arnaudo, I., Bonasso, M., Grossi, Pa, Basilico, C., Poggio, A., Bottari, G., Raise, E., Ebo, F., Lalla, F., Tositti, G., Resta, F., Loso, K., Lepri, Ac, Battegay, M., Bernasconi, E., Boni, J., Bucher, H., Burgisser, P., Cattacin, S., Cavassini, M., Dubs, R., Elzi, L., Erb, P., Fantelli, K., Fischer, M., Flepp, M., Fontana, A., Francioli, P., Furrer, H., Gorgievski, M., Hirschel, B., Kaiser, L., Kind, C., Klimkait, T., Lauper, U., Opravil, M., Paccaud, F., Pantaleo, G., Perrin, L., Piffaretti, Jc, Rickenbach, M., Rudin, C., Schmid, P., Schupbach, J., Speck, R., Telenti, A., Trkola, A., Vernazza, P., Weber, R., Yerly, S., Bronsveld, W., Hillebrand-Haverkort, Me, Prins, Jm, Bos, Jc, Schattenkerk, Jkme, Geerlings, Se, Godfried, Mh, Lange, Jma, Leth, Fc, Lowe, Sh, Meer, Jtm, Nellen, Fjb, Pogany, K., Poll, T., Ruys, Ta, Sankatsing, S., Steingrover, R., Twillert, G., Valk, M., Vonderen, Mga, Vrouenraets, Sme, Vugt, M., Wit, Fwmn, Kuijpers, Tw, Pajkrt, D., Scherpbier, Hj, Eeden, A., Ten Veen, Jh, Dam, Ps, Roos, Jc, Brinkman, K., Frissen, Phj, Weigel, Hm, Mulder, Jw, Gorp, Ecm, Meenhorst, Pl, Mairuhu, Ata, Ziekenhuis, S., Veenstra, J., Danner, Sa, Agtmael, Ma, Claessen, Fap, Perenboom, Rm, Rijkeboer, A., Vonderen, M., Richter, C., Berg, J., Leusen, R., Vriesendorp, R., Jeurissen, Fjf, Kauffmann, Rh, Koger, Elw, Bravenboer, B., Ten Napel, Chh, Kootstra, Gj, Sprenger, Hg, Miesen, Wmaj, Doedens, R., Scholvinck, Eh, Ten Kate, Rw, Houte, Dpf, Polee, M., Kroon, Fp, van den Broek, Dissel, Jt, Schippers, Ef, Schreij, G., Geest, Sv, Verbon, A., Koopmans, Pp, Keuter, M., Post, F., Ven, Ajam, Ende, Me, Gyssens, Ic, Feltz, M., Den Hollander, Jg, Marie, S., Nouwen, Jl, Rijnders, Bja, Vries, Tems, Driessen, G., Groot, R., Hartwig, N., Juttmann, Jr, Heul, C., Kasteren, Mee, Schneider, Mme, Bonten, Mjm, Borleffs, Jcc, Ellerbroek, Pm, Hoepelman, Im, Jaspers, Cajj, Schouten, I., Schurink, Cam, Geelen, Spm, Wolfs, Tfw, Blok, Wl, Tanis, Aa, Groeneveld, Php, Klinieken-Zwolle, I., Back, Nkt, Bakker, Meg, Berkhout, B., Jurriaans, S., Cuijpers, T., Rietra, Pjgm, Roozendaal, Kj, Pauw, W., Zanten, Ap, Blomberg, Bme, Savelkoul, P., Swanink, Cma, Franck, Pfh, Lampe, As, Hendriks, R., Schirm, J., Veenendaal, D., Storm, H., Weel, J., Zeijl, H., Kroes, Acm, Claas, Hcj, Bruggeman, Camva, Goossens, Vj, Galama, Jmd, Melchers, Wjg, Poort, Yag, Doornum, Gjj, Niesters, Mg, Osterhaus, Adme, Schutten, M., Buiting, Agm, Swaans, Cam, Boucher, Cab, Boel, E., Jansz, Af, Losso, M., Duran, A., Vetter, N., Karpov, I., Vassilenko, A., Clumeck, N., Wit, S., Poll, B., Colebunders, R., Machala, L., Rozsypal, H., Dalibor Sedlacek, Nielsen, J., Benfield, T., Kirk, O., Gerstoft, J., Katzenstein, T., Hansen, Abe, Skinhoj, P., Pedersen, C., Zilmer, K., Girard, Pm, Saint-Marc, T., Vanhems, P., Dietrich, M., Manegold, C., Lunzen, J., Stellbrink, Hj, Bickel, M., Goebel, Fd, Rockstroh, J., Schmidt, R., Kosmidis, J., Gargalianos, P., Sambatakou, H., Perdios, J., Panos, G., Filandras, A., Karabatsaki, E., Banhegyi, D., Mulcahy, F., Yust, I., Turner, D., Burke, M., Pollack, S., Hassoun, G., Sthoeger, Z., Maayan, S., Chiesi, A., Borghi, R., Pristera, R., Gabbuti, A., Montesarchio, E., Iacomi, F., Finazzi, R., Viksna, L., Chaplinskas, S., Hemmer, R., Staub, T., Bruun, J., Maeland, A., Ormaasen, V., Knysz, B., Gasiorowski, J., Horban, A., Prokopowicz, D., Wiercinska-Drapalo, A., Boron-Kaczmarska, A., Pynka, M., Beniowski, M., Mularska, E., Trocha, H., Antunes, F., Valadas, E., Mansinho, K., Matez, F., Duiculescu, D., Babes, V., Streinu-Cercel, A., Vinogradova, E., Rakhmanova, A., Jevtovic, D., Mokras, M., Stanekova, D., Gonzalez-Lahoz, J., Sanchez-Conde, M., Garcia-Benayas, T., Martin-Carbonero, L., Soriano, V., Clotet, B., Jou, A., Conejero, J., Tural, C., Gatell, Jm, Miro, Jm, Blaxhult, A., Karlsson, A., Pehrson, P., Soravia-Dunand, V., Kravchenko, E., Chentsova, N., Barton, S., Johnson, Am, Mercey, D., Johnson, Ma, Mocroft, A., Murphy, M., Weber, J., Scullard, G., Fisher, M., Brettle, R., Loveday, C., Gatell, J., Johnson, A., Vella, S., Gjorup, I., Friis-Moeller, N., Cozzi-Lepri, A., Bannister, W., Mollerup, D., Podlevkareva, D., Olsen, Ch, Kjaer, J., Raffanti, S., Dieterch, D., Becker, S., Scarsella, A., Fusco, G., Most, B., Balu, R., Rana, R., Beckerman, R., Ising, T., Irek, R., Johnson, B., Hirani, A., Dejesus, E., Pierone, G., Lackey, P., Irek, C., Burdick, J., Leon, S., Arch, J., Helm, Eb, Carlebach, A., Muller, A., Haberl, A., Nisius, G., Lennemann, T., Rottmann, C., Wolf, T., Stephan, C., Mosch, M., Gute, P., Locher, L., Lutz, T., Klauke, S., Knecht, G., Doerr, Hw, Sturmer, M., Hentig, N., Jennings, B., Beylot, J., Chene, G., Dupon, M., Longy-Boursier, M., Pellegrin, Jl, Ragnaud, Jm, Salamon, R., Thiebaut, R., Lewden, C., Lawson-Ayayi, S., Mercie, P., Moreau, Jf, Moriat, P., Bernard, N., Lacoste, D., Malvy, D., Neau, D., Blaizeau, Mj, Decoin, M., Delveaux, S., Hannapier, C., Labarrere, S., Lavignolle-Aurillac, V., Uwamaliya-Nziyumvira, B., Palmer, G., Touchard, D., Balestre, E., Alioum, A., Jacqmin-Gadda, H., Morlat, P., Bonarek, M., Bonnet, F., Coadou, B., Gellie, P., Nouts, C., Bocquentin, F., Dutronc, H., Lafarie, S., Aslan, A., Pistonne, T., Thibaut, P., Vatan, R., Chambon, D., La Taille, C., Cazorla, C., Ocho, A., Castera, L., Fleury, H., Lafon, Me, Masquelier, B., Pellegrin, I., Breilh, D., Blanco, P., Loste, P., Caunegre, L., Bonnal, F., Farbos, S., Ferrand, M., Ceccaldi, J., Tchamgoue, S., Witte, S., Buy, E., Alexander, C., Barrios, R., Braitstein, P., Brumme, Z., Chan, K., Cote, H., Gataric, N., Geller, J., Guillemi, S., Harrigan, Harris, M., Joy, R., Levy, A., Montaner, J., Montessori, V., Palepu, A., Phillips, E., Phillips, P., Press, N., Tyndall, M., Wood, E., Ballinger, J., Bhagani, S., Breen, R., Byrne, P., Carroll, A., Cropley, I., Cuthbertson, Z., Drinkwater, T., Fernandez, T., Geretti, Am, Murphy, G., Ivens, D., Johnson, M., Kinloch-De Loes, S., Lipman, M., Madge, S., Prinz, B., Bell, Dr, Shah, S., Swaden, L., Tyrer, M., Youle, M., Chaloner, C., Gumley, H., Holloway, J., Puradiredja, D., Sweeney, J., Tsintas, R., Bansi, L., Fox, Z., Lampe, F., Smith, C., Amoah, E., Clewley, G., Dann, L., Gregory, B., Jani, I., Janossy, G., Kahan, M., Thomas, M., Gill, Mj, Read, R., Schmeisser, V., Voigt, K., Wasmuth, Jc, Wohrmann, A., and Antiretroviral Therapy Cohort Coll
19. Impact of Substrate-Based Ablation of Ventricular Tachycardia on Cardiac Mortality in Patients With Implantable Cardioverter-Defibrillators.
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Komatsu Y, Maury P, Sacher F, Khairy P, Daly M, Lim HS, Zellerhoff S, Jesel L, Rollin A, Duparc A, Mondoly P, Aurillac-Lavignolle V, Shah A, Denis A, Cochet H, Derval N, Hocini M, Haïssaguerre M, and Jaïs P
- Abstract
Introduction: This study sought to determine if the acute procedural outcome of ventricular tachycardia (VT) substrate ablation is associated with a mortality benefit in patients with implantable cardioverter-defibrillators (ICD)., Methods and Results: A total of 195 ICD recipients (65 ± 11years) with ischemic or nonischemic dilated cardiomyopathy underwent substrate-based ablation targeting elimination of local abnormal ventricular activities (LAVA). Acute procedural success, which was defined as elimination of all identified LAVA in addition to the lack of VT inducibility, was achieved in 95 (49%) patients. During a median follow-up of 23 months, patients with acute procedure success had a significantly lower incidence of ICD shocks compared to those with ablation failure (8% vs. 30%, P < 0.001). In multivariate analysis, acute procedural success was associated with a lower risk of VT recurrence (hazard ratio [HR] 0.30, 95% confidence interval [CI] 0.18-0.49, P < 0.001) and all-cause mortality (HR 0.32, 95% CI 0.17-0.60, P < 0.001). While the impact of ablation success on mortality was not statistically significant in patients with LVEF > 35% (HR 0.45, 95% CI 0.15-1.34, P = 0.15) and those with NYHA class I/II (HR 0.63, 95% CI 0.29-1.40, P = 0.26), it was marked in patients with LVEF ≤ 35% (HR 0.30, 95% CI 0.14-0.62, P = 0.001) and NYHA class III/IV (HR 0.17, 95% CI 0.05-0.57, P = 0.004)., Conclusions: LAVA elimination in addition to VT noninducibility as a procedural outcome for substrate-based ablation is associated with reduced mortality and better VT-free survival during follow-up. This prognostic benefit may be most pronounced in patients with severe heart failure as indicated by severely depressed LV function and NYHA class III/IV symptoms., (© 2015 Wiley Periodicals, Inc.)
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- 2015
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20. Five-year outcome of catheter ablation of persistent atrial fibrillation using termination of atrial fibrillation as a procedural endpoint.
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Scherr D, Khairy P, Miyazaki S, Aurillac-Lavignolle V, Pascale P, Wilton SB, Ramoul K, Komatsu Y, Roten L, Jadidi A, Linton N, Pedersen M, Daly M, O'Neill M, Knecht S, Weerasooriya R, Rostock T, Manninger M, Cochet H, Shah AJ, Yeim S, Denis A, Derval N, Hocini M, Sacher F, Haissaguerre M, and Jais P
- Subjects
- Aged, Anti-Arrhythmia Agents therapeutic use, Atrial Fibrillation diagnosis, Atrial Fibrillation physiopathology, Disease-Free Survival, Electrophysiologic Techniques, Cardiac, Female, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Predictive Value of Tests, Proportional Hazards Models, Prospective Studies, Pulmonary Veins physiopathology, Recurrence, Reoperation, Risk Factors, Tachycardia, Supraventricular etiology, Tachycardia, Supraventricular surgery, Time Factors, Treatment Outcome, Atrial Fibrillation surgery, Catheter Ablation adverse effects, Pulmonary Veins surgery
- Abstract
Background: This study aimed to determine 5-year efficacy of catheter ablation for persistent atrial fibrillation (AF) using AF termination as a procedural end point., Methods and Results: One hundred fifty patients (57±10 years) underwent persistent AF ablation using a stepwise ablation approach (pulmonary vein isolation, electrogram-guided, and linear ablation) with the desired procedural end point being AF termination. Repeat ablation was performed for recurrent AF or atrial tachycardia. AF was terminated by ablation in 120 patients (80%). Arrhythmia-free survival rates after a single procedure were 35.3%±3.9%, 28.0%±3.7%, and 16.8%±3.2% at 1, 2, and 5 years, respectively. Arrhythmia-free survival rates after the last procedure (mean 2.1±1.0 procedures) were 89.7%±2.5%, 79.8%±3.4%, and 62.9%±4.5%, at 1, 2, and 5 years, respectively. During a median follow-up of 58 (interquartile range, 43-73) months after the last ablation procedure, 97 of 150 (64.7%) patients remained in sinus rhythm without antiarrhythmic drugs. Another 14 (9.3%) patients maintained sinus rhythm after reinitiation of antiarrhythmic drugs, and an additional 15 (10.0%) patients regressed to paroxysmal recurrences only. Failure to terminate AF during the index procedure (hazard ratio 3.831; 95% confidence interval, 2.070-7.143; P<0.001), left atrial diameter≥50 mm (hazard ratio 2.083; 95% confidence interval, 1.078-4.016; P=0.03), continuous AF duration≥18 months (hazard ratio 1.984; 95% confidence interval, 1.024-3.846; P<0.04), and structural heart disease (hazard ratio 1.874; 95% confidence interval, 1.037-3.388; P=0.04) predicted arrhythmia recurrence., Conclusions: In patients with persistent AF, an ablation strategy aiming at AF termination is associated with freedom from arrhythmia recurrence in the majority of patients over a 5-year follow-up period. Procedural AF nontermination and specific baseline factors predict long-term outcome after ablation., (© 2014 American Heart Association, Inc.)
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- 2015
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21. Endocardial ablation to eliminate epicardial arrhythmia substrate in scar-related ventricular tachycardia.
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Komatsu Y, Daly M, Sacher F, Cochet H, Denis A, Derval N, Jesel L, Zellerhoff S, Lim HS, Jadidi A, Nault I, Shah A, Roten L, Pascale P, Scherr D, Aurillac-Lavignolle V, Hocini M, Haïssaguerre M, and Jaïs P
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- Adult, Aged, Cardiomyopathies diagnosis, Cardiomyopathies mortality, Catheter Ablation mortality, Cicatrix pathology, Cohort Studies, Electrocardiography methods, Endocardium surgery, Feasibility Studies, Female, Follow-Up Studies, Humans, Male, Middle Aged, Postoperative Complications mortality, Postoperative Complications physiopathology, Retrospective Studies, Risk Assessment, Statistics, Nonparametric, Survival Rate, Tachycardia, Ventricular etiology, Treatment Outcome, Cardiomyopathies surgery, Catheter Ablation methods, Cicatrix complications, Epicardial Mapping methods, Tachycardia, Ventricular diagnosis, Tachycardia, Ventricular surgery
- Abstract
Objectives: We evaluated the feasibility and safety of epicardial substrate elimination with endocardial radiofrequency (RF) delivery in patients with scar-related ventricular tachycardia (VT)., Background: Epicardial RF delivery is limited by fat or associated with bleeding, extra-cardiac damages, coronary vessels and phrenic nerve injury. Alternative ablation approaches might be desirable., Methods: Forty-six patients (18 ischemic cardiomyopathy [ICM], 13 nonischemic dilated cardiomyopathy [NICM], 15 arrhythmogenic right ventricular cardiomyopathy [ARVC]) with sustained VT underwent combined endo- and epicardial mapping. All patients received endocardial ablation targeting local abnormal ventricular activities in the endocardium (Endo-LAVA) and epicardium (Epi-LAVA), followed by epicardial ablation if needed., Results: From a total of 173 endocardial ablations targeting Epi-LAVA at the facing site, 48 (28%) applications (ICM: 20 of 71 [28%], NICM: 3 of 39 [8%], ARVC: 25 of 63 [40%]) successfully eliminated the Epi-LAVA. Presence of Endo-LAVA, the most delayed and low bipolar amplitude of Epi-LAVA, low unipolar amplitude in the facing endocardium, and Epi-LAVA within a wall thinning area at computed tomography scan were associated with successful ablation. Endocardial ablation could abolish all Epi-LAVA in 4 ICM and 2 ARVC patients, whereas all patients with NICM required epicardial ablation. Endocardial ablation was able to eliminate Epi-LAVA at least partially in 15 (83%) ICM, 2 (13%) NICM, and 11 (73%) ARVC patients, contributing to a potential reduction in epicardial RF applications. Pericardial bleeding occurred in 4 patients with epicardial ablation., Conclusions: Elimination of Epi-LAVA with endocardial RF delivery is feasible and might be used first to reduce the risk of epicardial ablation., (Copyright © 2014 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.)
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- 2014
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22. Resistance mutations in subtype C HIV type 1 isolates from Indian patients of Mumbai receiving NRTIs plus NNRTIs and experiencing a treatment failure: resistance to AR.
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Deshpande A, Jauvin V, Magnin N, Pinson P, Faure M, Masquelier B, Aurillac-Lavignolle V, and Fleury HJ
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- HIV Infections genetics, HIV-1 classification, HIV-1 genetics, Humans, India, Mutation genetics, Polymorphism, Genetic genetics, Treatment Failure, Antiretroviral Therapy, Highly Active, Drug Resistance, Viral genetics, HIV Infections drug therapy, HIV-1 drug effects, RNA-Directed DNA Polymerase genetics, Reverse Transcriptase Inhibitors pharmacology
- Abstract
We present here the first data available on resistance to nucleoside reverse transcriptase inhibitors (NRTIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs) in India. In these subtype C isolates, we have observed most of the mutations noted in reverse transcriptase (RT) for subtype B with some additional substitutions (at positions 98, 203, 208, and 221) that will warrant attention in the algorithms used.
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- 2007
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23. Pravastatin in HIV-infected patients treated with protease inhibitors: a placebo-controlled randomized study.
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Bonnet F, Aurillac-Lavignolle V, Breilh D, Thiébaut R, Peuchant E, Bernard N, Lacoste D, Dabis F, Beylot J, Chêne G, and Morlat P
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- Adult, Anticholesteremic Agents adverse effects, Drug Interactions, Endpoint Determination, Female, HIV genetics, HIV Infections blood, HIV Infections metabolism, HIV Protease Inhibitors pharmacokinetics, Humans, Lipoproteins, IDL blood, Male, Middle Aged, Pravastatin adverse effects, RNA, Viral blood, Treatment Outcome, Anticholesteremic Agents administration & dosage, HIV isolation & purification, HIV Infections drug therapy, HIV Protease Inhibitors therapeutic use, Pravastatin administration & dosage
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Purpose: The objectives of the study were to assess the effects of pravastatin on plasma HIV RNA, lipid parameters, and protease inhibitor (PI) concentrations in patients treated with PI-containing regimens and with total cholesterol (TC) > or = 5.5 mmol/L., Method: A clinical trial including patients randomized to receive pravastatin or matching placebo for 12 weeks was implemented., Results: Twelve patients were included in the pravastatin group and 9 in the placebo group. At week 12 (W12), no patient had experienced virological failure. Between week 0 (W0) and W12, the median differences for TC were -1.4 mmol/L in the pravastatin group and +0.2 mmol/L in the placebo group (p = .005); for LDL, they were -1.0 mmol/L and +0.3 (p = .007), respectively. A significant decrease of the PI concentration (12 hours after administration) ratio W12 - W0/W0 was noticed in the pravastatin group (-0.2 [interquartile range, -0.3 to -0.1] as compared with the placebo group (0.1 [IQR, 0.0 to 0.3]) (p = .03). When the study was restricted to patients treated with lopinavir/ritonavir, a decrease from 3.8 microg/mL at baseline to 2.9 mug/mL at W12 was noticed in the pravastatin arm (p = .04) but not in the control arm (p = 1.00). No clinical adverse event reached a severity of grade 3., Conclusion: We observed in this study that the use of pravastatin in PI-treated patients was not associated with major change in the plasma HIV RNA on 12 weeks of follow-up. However, we found a trend of decrease of the trough PI concentration at W12, suggesting a possible drug-drug interaction of pravastatin on PI metabolism.
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- 2007
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24. Primary resistance to enfuvirtide (T20) in recently HIV-1 infected, antiretroviral-naive patients from the ANRS Aquitaine Cohort.
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Peuchant O, Capdepont S, Ragnaud JM, Aurillac-Lavignolle V, Thiébaut R, Fleury H, and Masquelier B
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- Adult, Enfuvirtide, Female, HIV Envelope Protein gp41 genetics, HIV Infections epidemiology, HIV Infections transmission, HIV Infections virology, HIV Protease genetics, HIV Reverse Transcriptase genetics, HIV-1 enzymology, HIV-1 genetics, Humans, Male, Microbial Sensitivity Tests, Mutation, Phylogeny, Drug Resistance, Viral genetics, HIV Envelope Protein gp41 pharmacology, HIV Fusion Inhibitors pharmacology, HIV Infections drug therapy, HIV-1 drug effects, Peptide Fragments pharmacology
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Background: Transmission of HIV-1 variants with resistance to reverse transcriptase (RT) and protease inhibitors has been widely characterized in developed countries. However, no clear evidence of primary resistance to HIV-1 fusion inhibitors has been shown so far. We wished to investigate the possibility of genotypic resistance to enfuvirtide (T20) in a cohort of antiretroviral-naive, recently infected patients., Methods: We included patients from the Aquitaine Cohort with an estimated date of seroconversion in 2004 and 2005, a plasma sample obtained less than 18 months after seroconversion and no prior history of antiretroviral therapy. RT, protease and gp41 sequences were determined by direct population sequencing from plasma samples and drug resistance mutations were reported., Results: A total of 55 patients were included in the study. The overall prevalence of transmitted HIV-1 resistance was 20%. Two patients had viruses with resistance mutations to T20. The first case had an N42D mutation in the HR1 region of the gp41, along with transmitted resistance mutations in the protease (D30N, M361, N88D) and in the RT (M41L, L210W, T215D). The second case had a G36D HR1 mutation, with no evidence of other drug resistance mutations., Conclusion: We have shown the first cases of primary resistance to T20 in recently infected patients in southwestern France. Epidemiological surveillance of the transmission of drug-resistant HIV-1 should include the resistance to T20.
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- 2007
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25. An additive/subtractive genotypic score as a determinant of the virological response to didanosine in HIV-1 infected patients.
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Capdepont S, Aurillac-Lavignolle V, Faure M, Dupon M, Morlat P, Ragnaud JM, Chêne G, Fleury H, and Masquelier B
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- Algorithms, Drug Resistance, Viral, Genotype, HIV Infections virology, Humans, Multivariate Analysis, Mutation, RNA, Viral blood, RNA, Viral genetics, Retrospective Studies, Time Factors, Viral Load, Anti-HIV Agents therapeutic use, Didanosine therapeutic use, HIV Infections drug therapy, HIV-1 drug effects, HIV-1 genetics, Reverse Transcriptase Inhibitors therapeutic use
- Abstract
Objective: To assess the genotypic determinants of the virological response (VR) to didanosine (ddI) in nucleoside reverse transcriptase inhibitors (NRTI)-experienced patients., Methods: Human immunodeficiency virus type 1 (HIV-1) genotype was determined at baseline in 74 ddI-naive-patients with baseline viral load >500 copies/ml and receiving ddI as part of a new regimen. VR was defined as a plasma HIV-1 RNA <50 copies/ml after three months on ddI. NRTI resistance mutations associated with higher or lower frequencies of VR with a p-value<0.25 were retained in different sets of mutations, where the mutations associated with a worse VR were added, whereas the mutations associated with a better VR were subtracted. The most significant mutation scores were then studied in a multivariate analysis., Results: Changes at three codons (M41L, L210W, T215Y/F/D/C/E) were associated with a worse VR and three mutations (K70R, M184V, K219Q) with a better VR. The strongest association with the VR was obtained with the score M41L+L210W+T215Y/F/D/C/E-K70R-K219Q. The score was independently associated with the VR in the multivariate analysis., Conclusion: Taking into account the mutations associated with a better VR may improve genotypic resistance algorithms. Our results are of interest for the management of antiretroviral therapy in NRTI-experienced patients.
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- 2006
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26. Change in atherosclerosis progression in HIV-infected patients: ANRS Aquitaine Cohort, 1999-2004.
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Thiébaut R, Aurillac-Lavignolle V, Bonnet F, Ibrahim N, Cipriano C, Neau D, Dupon M, Dabis F, and Mercié P
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- Adult, Antiretroviral Therapy, Highly Active, Arteriosclerosis pathology, Arteriosclerosis therapy, Carotid Artery Diseases pathology, Carotid Artery Diseases virology, Carotid Artery, Common, Cholesterol, HDL blood, Disease Progression, Drug Therapy, Combination, Female, Follow-Up Studies, France, HIV Infections pathology, HIV Infections therapy, Humans, Hypolipidemic Agents therapeutic use, Male, Middle Aged, Risk Factors, Smoking, Tunica Intima pathology, Arteriosclerosis virology, HIV Infections complications, HIV-1
- Abstract
This study reported the changes in carotid intima-media thickness (IMT) during a 36-month period in 233 HIV-infected patients. Median IMT increased in the first 12 months and then decreased by month 36. The prevalence of treatment with lipid-lowering agents and protease inhibitor-free highly active antiretroviral therapy regimens increased, whereas smoking prevalence decreased. The progression of atherosclerosis in HIV-infected patients can be controlled. The impact of individual measures to reduce the cardiovascular risk should be evaluated further.
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- 2005
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27. Human immunodeficiency virus type 1 genotypic and pharmacokinetic determinants of the virological response to lopinavir-ritonavir-containing therapy in protease inhibitor-experienced patients.
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Masquelier B, Breilh D, Neau D, Lawson-Ayayi S, Lavignolle V, Ragnaud JM, Dupon M, Morlat P, Dabis F, and Fleury H
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- Adult, Amino Acid Substitution, Drug Combinations, Female, Genotype, HIV Infections virology, HIV Protease genetics, Humans, Lopinavir, Male, Models, Biological, RNA, Viral blood, Salvage Therapy, Anti-HIV Agents pharmacokinetics, Anti-HIV Agents therapeutic use, HIV Infections drug therapy, HIV Infections metabolism, HIV Protease Inhibitors pharmacokinetics, HIV Protease Inhibitors therapeutic use, HIV-1 drug effects, HIV-1 genetics, Pyrimidinones pharmacokinetics, Pyrimidinones therapeutic use, Ritonavir pharmacokinetics, Ritonavir therapeutic use
- Abstract
The response to regimens including lopinavir-ritonavir (LPV/r) in patients who have received multiple protease (PR) inhibitors (PI) can be analyzed in terms of human immunodeficiency virus type 1 (HIV-1) genotypic and pharmacokinetic (pK) determinants. We studied these factors and the evolution of HIV-1 resistance in response to LPV/r in a prospective study of patients receiving LPV/r under a temporary authorization in Bordeaux, France. HIV-1 PR and reverse transcriptase sequences were determined at baseline LPV/r for all the patients and at month 3 (M3) and M6 in the absence of response to treatment. pK measurements were determined at M1 and M3. Virological failure (VF) was defined as a plasma viral load >or=400 copies/ml at M3. A multivariate analysis of the predictors of VF, including clinical and biological characteristics and the treatment history of the patients, was performed. The PR gene sequence at M0, including individual mutations or a previously defined LPV mutation score (D. J. Kempf, J. D. Isaacson, M. S. King, S. C. Brun, Y. Xu, K. Real, B. M. Bernstein, A. J. Japour, E. Sun, and R. A. Rode, J. Virol. 75:7262-7269, 2001), and the individual exposure to LPV were also included covariates. Sixty-eight patients were enrolled. Thirty-four percent had a virological response at M3. An LPV mutation score of >5 mutations, the presence of the PR I54V mutation at baseline, a high number of previous PIs, prior therapy with ritonavir or indinavir, absence of coprescription of efavirenz, and a lower exposure to LPV or lower LPV trough concentrations were independently associated with VF on LPV/r. Additional PI resistance mutations, including primary mutation I50V, could be selected in patients failing on LPV/r. Genotypic and pK parameters should be used to optimize the virological response to LPV/r in PI-experienced patients and to avoid further viral evolution.
- Published
- 2002
- Full Text
- View/download PDF
28. Evaluation of cardiovascular risk factors in HIV-1 infected patients using carotid intima-media thickness measurement.
- Author
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Mercié P, Thiébaut R, Lavignolle V, Pellegrin JL, Yvorra-Vives MC, Morlat P, Ragnaud JM, Dupon M, Malvy D, Bellet H, Lawson-Ayayi S, Roudaut R, and Dabis F
- Subjects
- Adult, Age Distribution, Analysis of Variance, Cardiovascular Diseases diagnosis, Cardiovascular Diseases epidemiology, Carotid Artery Diseases diagnosis, Cohort Studies, Comorbidity, Female, HIV Infections diagnosis, Humans, Linear Models, Male, Multivariate Analysis, Probability, Prognosis, Prospective Studies, Risk Assessment, Risk Factors, Sensitivity and Specificity, Sex Distribution, Carotid Arteries, Carotid Artery Diseases epidemiology, HIV Infections epidemiology, HIV-1 isolation & purification, Tunica Intima pathology
- Abstract
Background: Highly active antiretroviral therapies (HAART) in HIV-infected patients are often associated with lipodystrophy syndrome and metabolic disorders. Atherogenic lipid profile could expose these patients to atheromatous cardiovascular disease. We describe carotid artery intima-media thickness (IMT), a surrogate marker of atherosclerosis, according to HIV status, antiretroviral treatment, lipodystrophy and conventional cardiovascular risk factors., Method: In a multicenter prospective cohort study we have surveyed HIV-infected subjects with a carotid IMT measurement by B-mode ultrasonography. We collected information on lipodystrophy clinical manifestations, age, gender, body mass index (BMI), smoking habits, alcohol intake, systolic blood pressure, HIV transmission category, AIDS stage, type and duration of HAART, CD4+ cell count, plasma HIV-1 RNA, glucose, insulin, total cholesterol and homocysteine., Results: Four hundred and twenty-three HIV-infected patients were studied. The median carotid IMT measurement was 0.54 mm (range: 0.50-0.60). Lipodystrophy syndrome was diagnosed in 161 HIV-infected patients (38.1%). In univariate linear regression, IMT was significantly higher (P<0.05) with older age, male gender, higher body mass index, higher waist-to-hip ratio, increased systolic blood pressure, total cholesterol, glucose disorders and homocysteine, regular smoking and alcohol consumption, lipodystrophy and HAART. In a multivariate analysis, the effect of lipodystrophy and HAART disappeared after adjustment for other cardiovascular risk factors., Conclusions: It was concluded that only conventional cardiovascular risk factors are independently associated with increased IMT in HIV-infected patients.
- Published
- 2002
- Full Text
- View/download PDF
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