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Lack of community involvement in social and religious activities in the environment around the mosque is one of the problems that needs attention to create a human resource that has faith as the foundation of one's life, especially in Islamic spiritual field. The decreasing level of community involvement in this mosque environment demands the holding of community-based education in order to meet the learning needs of the community as adults. One of the activities that play a role in meeting social and religious needs is Sunday morning recitation activities with informal learning and the learning process can occur anywhere, including in a non-formal educational institution such as a taklim assembly. The aims of this research are 1). Describe the needs of adults in improving religious knowledge through Sunday morning recitation activities, 2). Describe the process of implementing Sunday morning recitation at the Baiturrahman Mosque in facilitating the learning needs of adults. This study uses a qualitative research method with a case study research type. This research was conducted at the Baiturrahman Tepus Mosque. The informants in this study were the chairman of the takmir, the vice chairman of the takmir, and the Sunday morning recitation congregation. Data collection techniques were carried out by interviews, observation, and documentation. Data analysis techniques used are data reduction, data presentation, and efforts to draw conclusions. Meanwhile, in this study, data validity was tested using source triangulation and technical triangulation. The research results obtained from this study are that the Sunday Morning Recitation Activities at the Baiturrahman Mosque are one of the informal learning facilities or containers that focus on the needs of Islamic religious learning for adults. In Sunday morning recitation activities, humans as adults need religious knowledge because humans as adults have obligations and responsibilities to God, therefore humans are required to continue learning in fulfilling the necessities of life and their religion as religious beings in this world. As for the process of implementing Sunday morning recitation activities in facilitating the learning needs of adults, starting from planning, organizing, implementing, and evaluating. Planning is carried out by holding meetings and deliberations to discuss the planning of Sunday morning activities. Organizing by forming a committee for Sunday morning recitation activities. Sunday morning recitation activities are held on Sunday or Sunday every two weeks. Evaluate activities to measure the success and constraints of the program that has been implemented as an evaluation of improvements for further activities. Abstrak: Minimnya keterlibatan masyarakat dalam kegiatan-kegiatan sosial dan keagamaan di lingkungan sekitar masjid merupakan salah satu permasalahan yang perlu diperhatikan untuk menciptakan suatu sumber daya manusia yang mempunyai keyakinan sebagai pondasi hidup seseorang khususnya di bidang spiritual keagamaan Islam. Menurunnya tingkat keterlibatan masyarakat di lingkungan masjid ini, menuntut diselenggarakannya pendidikan berbasis masyarakat dalam rangka memenuhi kebutuhan belajar masyarakat sebagai orang dewasa. Salah satu kegiatan yang berperan dalam memenuhi kebutuhan sosial dan keagamaan yaitu kegiatan pengajian ahad pagi dengan pembelajaran informal dan proses pembelajarannya dapat terjadi dimana saja, termasuk didalam sebuah lembaga pendidikan nonformal seperti majelis taklim. Tujuan dalam penelitian ini adalah 1). Mendeskripsikan kebutuhan orang dewasa dalam meningkatkan ilmu keagamaan melalui kegiatan pengajian ahad pagi, 2). Mendeskripsikan proses pelaksanaan pengajian ahad pagi di Masjid Baiturrahman dalam memfasilitasi kebutuhan belajar orang dewasa. Penelitian ini menggunakan metode penelitian kualitatif dengan jenis penelitian studi kasus. Penelitian ini dilaksanakan di Masjid Baiturrahman Tepus. Informan dalam penelitian ini adalah ketua takmir, wakil ketua takmir, dan jamaah pengajian ahad pagi. Teknik pengumpulan data dilakukan dengan wawancara, observasi, dan dokumentasi. Teknik analisis data yang digunakan yaitu reduksi data, penyajian data, dan upaya penarikan kesimpulan. Sedangkan dalam penelitian ini, uji keabsahan data menggunakan triangulasi sumber dan triangulasi teknik. Hasil penelitian yang diperoleh dari penelitian ini adalah Kegiatan Pengajian Ahad Pagi di Masjid Baiturrahman merupakan salah satu sarana atau wadah pembelajaran informal yang berfokus pada kebutuhan belajar keagamaan Islam bagi orang dewasa. Dalam kegiatan pengajian ahad pagi, manusia sebagai orang dewasa membutuhkan ilmu keagamaan karena manusia sebagai orang dewasa memiliki kewajiban dan tanggung jawab kepada Tuhan, oleh karena itu manusia dituntut untuk terus belajar dalam memenuhi kebutuhan hidup dan agamanya sebagai makhluk hidup yang beragama di dunia ini. Adapun proses pelaksanaan kegiatan pengajian ahad pagi dalam memfasilitasi kebutuhan belajar orang dewasa yaitu mulai dari perencanaan, pengorganisasian, pelaksanaan, dan evaluasi. Perencanaan dilakukan dengan mengadakan kegiatan pertemuan dan musyawarah membahas perencanaan kegiatan ahad pagi. Pengorganisasian dengan membentuk pengurus kegiatan pengajian ahad pagi. Pelaksanaan kegiatan pengajian ahad pagi dilaksanakan pada hari Minggu atau Ahad setiap dua minggu sekali. Melakukan evaluasi kegiatan untuk mengukur keberhasilan dan kendala program yang telah dilaksanakan sebagai evaluasi perbaikan untuk kegiatan selanjutnya.

Lanjut usia atau lansia merupakan seseorang dengan usia lebih dari 60 tahun. Lansia dibagimenjadi tiga kategori yaitu lansia muda (60-69 tahun), lansia madya (70-79 tahun) dan lansia tua(>80 tahun). Dirjen Kesmas menjelaskan upaya “BAHAGIA” untuk mencapai keadaan sehat sertabahagia untuk lansia. Lansia disarankan menghindari berat badan berlebih, atur makan dengan giziseimbang, hindari faktor risiko penyakit tidak menular. Penyakit tidak menular pada pra-lansia (45-59 tahun) didapatkan obesitas (26,10%), hipertensi (21,2%), penyakit sendi (12%), diabetes melitus(4,5%). Hal yang sama juga terjadi lansia yaitu hipertensi (32,5%), penyakit sendi (18%), obesitas(14,6%) dan diabetes melitus (5,7%).Kegiatan ini dilakukan Selasa, 9 Agustus 2022. Tempat pelaksanaan kegiatan pengabdiankepada masyarakat (PkM) di komunitas RW 16-2 Kebon Melati Jakarta Pusat. Kegiatan iniberkerjasama dengan Puskesmas Kelurahan Kebon Melati Tanah Abang, Jakarta Pusat. Kegiatandilakukan secara luring, dihadiri oleh kader lansia, perawat dari puskesmas, masyarakat, mahasiswadan dosen STIK Budi Kemuliaan dengan protokol kesehatan. Kegiatan ini dihadiri oleh 41 pra lansiadan lansia.Hasil edukasi gizi sehat pada lansia ini didapatkan hasil yang baik. Dari tiga materi (10 pesangizi seimbang, bahan makanan yang dianjurkan dan dihindari) didapatkan sebagian besar lansiadapat menjawab secara lisan dengan baik. Terdapat tiga lansia memiliki kadar GDS >200mg/dl dansudah dilakukan rujukan ke puskesmas kelurahan secara langsung. Saran untuk kegiatan pengabdiankepada masyarakat dengan target lansia, dilakukan evaluasi pengetahuan secara tertulismenggunakan teknologi serta menambah jumlah posyandu lansia.

This study aimed to analyze the effect of audit delay, debt default and company growth on going concern audit opinion with auditor reputation as a moderating variable. This research is a quantitative study using logistic regression with the SPSS 26 analysis tool. The sample of this research is the mining sub-sector companies listed on the Indonesia Stock Exchange in 2018-2020. The research sample was taken using purposive sampling method which resulted in 96 samples. Based on the hypothesis test, this research reveals that mining sub-sector companies listed on the Indonesia Stock Exchange during 2018-2020 will receive a going concern audit opinion if the company fails to pay its debts. On the other side, audit delay and company growth do not cause the company to accept a going concern audit opinion. The reputation of the auditor has not been able to encourage the acceptance of a going concern audit opinion. Keywords : audit delay, debt default, compony growth, reputasi auditor, going concern audit opinion

This study aims to determine the relationship between the 2018 Final Year Students who Compose Thesis at the Psychology Study Program, University of Muhammadiyah Sidoarjo. This research is a type of quantitative research with a correlational approach. The variables in this study are hardiness as the independent variable and academic procrastination as the dependent variable. This research was conducted at Muhammadiyah University of Sidoarjo with a population of 154 students. The sample in this study were 113 students who were taken using simple random sampling technique. Data analysis used the Pearson Product Moment correlation technique with the help of the JASP 0.16 program. The results of data analysis showed that the correlation coefficient was -0.698 with a significance of

Penelitian ini bertujuan untuk memberikan bukti empiris pengaruh shift kerja terhadap kinerja karyawan, pengaruh motivasi terhadap kinerja karyawan, dan pengaruh shift kerja melalui motivasi sebagai variabel intervening terhadap kinerja karyawan di Ruang UGD rumah sakit di Kota Madiun. Penelitian ini dilaksanakan di ruang UGD rumah sakit-rumah sakit yang ada di Kota Madiun. Penelitian ini menggunakan pendekatan kuantitatif dengan desain penelitian asosiatif. Populasi penelitian ini adalah seluruh sebagai karyawan bagian UGD rumah sakit di Kota Madiun yaitu: RSUD dr. Soedono Madiun, RSUD Kota Madiun, dan RS Paru Manguharjo, Rumah Sakit Islam Siti Aisyah Madiun, Rumah Sakit Griya Husada, Rumah Sakit Santa Clara, Rumah Sakit Ibu dan Anak Al-Hasanah, serta Rumah Sakit DKT miliki TNI Angkatan Darat yang berjumlah 155 orang. Teknik sampling yang digunakan adalah sampling jenuh. Instrumen penelitian kuesioner. Teknik analisis data menggunakan path analysis. Hasil penelitian membuktikan bahwa: (1) Shift kerja berpengaruh positif dan signifikan terhadap kinerja karyawan di Ruang UGD rumah sakit di Kota Madiun. (2) Shift kerja berpengaruh positif dan signifikan terhadap motivasi karyawan di Ruang UGD rumah sakit di Kota Madiun. (3) Motivasi berpengaruh positif dan signifikan terhadap kinerja karyawan di Ruang UGD rumah sakit di Kota Madiun. (4) Shift kerja melalui motivasi sebagai variabel intervening tidak berpengaruh terhadap kinerja karyawan di Ruang UGD rumah sakit di Kota Madiun. Kata Kunci: shift kerja, kinerja karyawan, motivasi

Understanding changes in gene expression under the effects of a perturbation is a key goal of systems biology. A powerful approach to address this goal uses gene networks and describes the perturbation’s effects as a rewiring of each gene’s connections. This approach is known as differential network (DN) analysis. Here, we used DNs to analyze RNA-sequencing time series datasets, focusing on expression changes: (i) In the saliva of a human subject after vaccination with a pneumococcal vaccine (PPSV23), and (ii) in B cells treatedex vivowith a monoclonal antibody drug (Rituximab). Using network community detection, we revealed the collective behavior of clusters of genes, and detected communities of genes based on their longitudinal behavior, and corresponding pathway activations. We identified biological pathways consistent with the mechanism of action of the vaccine and with Rituximab’s targets. The approach may be useful in drug development by providing an effective analysis of expressing changes in response to a drug.

Saliva omics has immense potential for non-invasive diagnostics, including monitoring very young or elderly populations, or individuals in remote locations. In this study, multiple saliva omics from an individual were monitored over three periods (100 timepoints) involving: (1) hourly sampling over 24 h without intervention, (2) hourly sampling over 24 h including immune system activation using the standard 23-valent pneumococcal polysaccharide vaccine, (3) daily sampling for 33 days profiling the post-vaccination response. At each timepoint total saliva transcriptome and proteome, and small RNA from salivary extracellular vesicles were profiled, including mRNA, miRNA, piRNA and bacterial RNA. The two 24-h periods were used in a paired analysis to remove daily variation and reveal vaccination responses. Over 18,000 omics longitudinal series had statistically significant temporal trends compared to a healthy baseline. Various immune response and regulation pathways were activated following vaccination, including interferon and cytokine signaling, and MHC antigen presentation. Immune response timeframes were concordant with innate and adaptive immunity development, and coincided with vaccination and reported fever. Overall, mRNA results appeared more specific and sensitive (timewise) to vaccination compared to other omics. The results suggest saliva omics can be consistently assessed for non-invasive personalized monitoring and immune response diagnostics.

Background Type 2 Diabetes (T2DM) is a global public health priority affecting 425 million adults with 352 million more at risk of developing T2DM. Intensive group programmes focusing on weight loss and physical activity can prevent or postpone the development of T2DM, but certain groups (e.g working age) find it difficult to attend sessions. Digital options offer a flexible alternative with the potential to widen access and increase uptake. The National Health Service of England (NHSE) has initiated a pilot of a national digital Diabetes Prevention Programme (DPP) to determine its feasibility, acceptability and impact. This is the first national digital DPP in the world, and lessons learnt will be of interest internationally. Methods Single arm, pre-post design located in 9 geographic areas with a total population of 5.6 million adults. Adults identified in primary care as being at risk of T2DM were referred to a digital diabetes prevention intervention (DDPI). Baseline data included demographic details (age, gender, ethnicity, highest level of education achieved) and clinical data (weight (kg), Body Mass Index (BMI) and glycated haemoglobin (HbA1c mmol/mol)). Clinical data were collected at baseline, 6 and 12 months, with the primary outcome change in HbA1c at 12 months. Results The programme was effectively implemented in all 9 areas with a total of 5,053 referrals. 3,228 (64%) of those referred registered with a DDPI. Mean baseline values for registered patients was BMI 31.1, Weight 87.7 kg and HbA1c 43.4 mmol/mol. To date, 2,687 patients have reached the 6 month point, of whom 867 dropped out. Mean (95% CI) HbA1c change was -1.6 (-1.8 to -1.4) mmol/mol (n = 1,264) and mean (95% CI) weight change was -4 (-4.3 to -3.7) kg (n = 1,184). Conclusions A national digital DPP is feasible, acceptable to patients and healthcare providers, and appears to be associated with beneficial impacts on HbA1c and weight in those who participate. Key messages A digital DPP is feasible, acceptable and associated with reductions in weight and HbA1c amongst participants. A digital DPP could be a useful part of a public health strategy to combat T2DM.

Chronic obstructive pulmonary disease (COPD) was classified by the Centers for Disease Control and Prevention in 2014 as the 3rd leading cause of death in the United States (US). The main cause of COPD is exposure to tobacco smoke and air pollutants. Problems associated with COPD include under-diagnosis of the disease and an increase in the number of smokers worldwide. The goal of our study is to identify disease variability in the gene expression profiles of COPD subjects compared to controls. We used pre-existing, publicly available microarray expression datasets to conduct a meta-analysis. Our inclusion criteria for microarray datasets selected for smoking status, age and sex of blood donors reported. Our datasets used Affymetrix, Agilent microarray platforms (7 datasets, 1,262 samples). We re-analyzed the curated raw microarray expression data using R packages, and used Box-Cox power transformations to normalize datasets. To identify significant differentially expressed genes we ran an analysis of variance with a linear model with disease state, age, sex, smoking status and study as effects that also included binary interactions. We found 1,513 statistically significant (Benjamini-Hochberg-adjusted p-value

Alzheimer’s disease (AD) has been categorized by the Centers for Disease Control and Prevention (CDC) as the 6thleading cause of death in the United States. AD is a significant health-care burden because of its increased occurrence (specifically in the elderly population) and the lack of effective treatments and preventive methods. With an increase in life expectancy, the CDC expects AD cases to rise to 15 million by 2060. Aging has been previously associated with susceptibility to AD, and there are ongoing efforts to effectively differentiate between normal and AD age-related brain degeneration and memory loss. AD targets neuronal function and can cause neuronal loss due to the buildup of amyloid-beta plaques and intracellular neurofibrillary tangles.Our study aims to identify temporal changes within gene expression profiles of healthy controls and AD subjects. We conducted a meta-analysis using publicly available microarray expression data from AD and healthy cohorts. For our meta-analysis, we selected datasets that reported donor age and gender, and used Affymetrix and Illumina microarray platforms (8 datasets, 2,088 samples). Raw microarray expression data were re-analyzed, and normalized across arrays. We then performed an analysis of variance, using a linear model that incorporated age, tissue type, sex, and disease state as effects, as well as study to account for batch effects, and including binary interaction between factors. Our results identified 3,735 statistically significant (Bonferroni adjusted pOverall our approach allowed us to effectively combine multiple available microarray datasets and identify gene expression differences between AD and healthy individuals including full age and tissue type considerations. Our findings provide potential gene and pathway associations that can be targeted to improve AD diagnostics and potentially treatment or prevention. (US).