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1. Body mass index stratified meta-analysis of genome-wide association studies of polycystic ovary syndrome in women of European ancestry

Author

Burns, Kharis, Mullin, Benjamin H., Moolhuijsen, Loes M. E., Laisk, Triin, Tyrmi, Jaakko S., Cui, Jinrui, Actkins, Ky’Era V., Louwers, Yvonne V., Davis, Lea K., Dudbridge, Frank, Azziz, Ricardo, Goodarzi, Mark O., Laivuori, Hannele, Mägi, Reedik, Visser, Jenny A., Laven, Joop S. E., Wilson, Scott G., Day, Felix R., and Stuckey, Bronwyn G. A.

Published
2024
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2. The normal and abnormal menstrual cycle

Author

Laven, Joop S. E., Lambalk, Nils C. B., Steegers, Eric A.P., editor, de Groot, Christianne J.M., editor, Hilders, Carina G.J.M., editor, Hoek, Annemieke, editor, Jaddoe, Vincent W.V., editor, Schoenmakers, Sam, editor, and Zweemer, Ronald P., editor

Published
2024
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6. Clustering Identifies Subtypes With Different Phenotypic Characteristics in Women With Polycystic Ovary Syndrome.

Author

van der Ham, Kim, Moolhuijsen, Loes M E, Brewer, Kelly, Sisk, Ryan, Dunaif, Andrea, Laven, Joop S E, Louwers, Yvonne V, and Visser, Jenny A

Subjects
DIASTOLIC blood pressure, POLYCYSTIC ovary syndrome, ANTI-Mullerian hormone, BODY mass index, HIERARCHICAL clustering (Cluster analysis)
Abstract

Context Hierarchical clustering (HC) identifies subtypes of polycystic ovary syndrome (PCOS). Objective This work aimed to identify clinically significant subtypes in a PCOS cohort diagnosed with the Rotterdam criteria and to further characterize the distinct subtypes. Methods Clustering was performed using the variables body mass index (BMI), luteinizing hormone (LH), follicle-stimulating hormone, dehydroepiandrosterone sulfate, sex hormone–binding globulin (SHBG), testosterone, insulin, and glucose. Subtype characterization was performed by analyzing the variables estradiol, androstenedione, dehydroepiandrosterone, cortisol, anti-Müllerian hormone (AMH), total follicle count (TFC), lipid profile, and blood pressure. Study participants were girls and women who attended our university hospital for reproductive endocrinology screening between February 1993 and February 2021. In total, 2502 female participants of European ancestry, aged 13 to 45 years with PCOS (according to the Rotterdam criteria), were included. A subset of these (n = 1067) fulfilled the National Institutes of Health criteria (ovulatory dysfunction and hyperandrogenism). Main outcome measures included the identification of distinct PCOS subtypes using cluster analysis. Additional clinical variables associated with these subtypes were assessed. Results Metabolic, reproductive, and background PCOS subtypes were identified. In addition to high LH and SHBG levels, the reproductive subtype had the highest TFC and levels of AMH (all P <.001). In addition to high BMI and insulin levels, the metabolic subtype had higher low-density lipoprotein levels and higher systolic and diastolic blood pressure (all P <.001). The background subtype had lower androstenedione levels and features of the other 2 subtypes. Conclusion Reproductive and metabolic traits not used for subtyping differed significantly in the subtypes. These findings suggest that the subtypes capture distinct PCOS causal pathways. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Communication and ethical considerations for fertility preservation for patients with childhood, adolescent, and young adult cancer: recommendations from the PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group

Author

Anderson, Richard A, Barnbrock, Anke, Beck, Joern D, Bos, Annelies M E, Calaminus, Gabriele, Constine, Louis S, Demeestere, Isabelle, Denzer, Christian, Grabow, Desiree, di Iorgi, Natascia, Hoefgen, Holly R, Jahnukainen, Kirsi, Kaatsch, Peter, Kebudi, Rejin, Lambalk, Cornelis, Langer, Thorsten, Loonen, Jacqueline, Lorenzo, Armando, Meacham, Lillian R, Meissner, Andreas, Mitchell, Rod T, Nahata, Leena, Ranft, Andreas, Dinkelman-Smit, Marij, Stern, Catharyn, Stutz-Grunder, Eveline, Tournaye, Herman, van Dorp, Wendy, van Pelt, Ans M M, de Vries, Andrica, Yu, Richard, Mulder, Renée L, Font-Gonzalez, Anna, van Dulmen-den Broeder, Eline, Quinn, Gwendolyn P, Ginsberg, Jill P, Loeffen, Erik A H, Hudson, Melissa M, Burns, Karen C, van Santen, Hanneke M, Berger, Claire, Diesch, Tamara, Dirksen, Uta, Giwercman, Aleksander, Gracia, Clarisa, Hunter, Sarah E, Kelvin, Joanne F, Klosky, James L, Laven, Joop S E, Lockart, Barbara A, Neggers, Sebastian J C M M, Peate, Michelle, Phillips, Bob, Reed, Damon R, Tinner, Eva Maria E, Byrne, Julianne, Veening, Margreet, van de Berg, Marleen, Verhaak, Chris M, Anazodo, Antoinette, Rodriguez-Wallberg, Kenny, van den Heuvel-Eibrink, Marry M, Asogwa, Ogechukwu A, Brownsdon, Alexandra, Wallace, W Hamish, Green, Daniel M, Skinner, Roderick, Haupt, Riccardo, Kenney, Lisa B, Levine, Jennifer, van de Wetering, Marianne D, Tissing, Wim J E, Paul, Norbert W, Kremer, Leontien C M, and Inthorn, Julia

Published
2021
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13. Fertility preservation for female patients with childhood, adolescent, and young adult cancer: recommendations from the PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group

Author

Berger, Claire, Diesch, Tamara, Dirksen, Uta, Ginsberg, Jill, Giwercman, Aleksander, Grabow, Desiree, Gracia, Clarisa, Hunter, Sarah E, Inthorn, Julia, Kaatsch, Peter, Kelvin, Joanne F, Klosky, James L, Laven, Joop S E, Lockart, Barbara A, Neggers, Sebastian JCMM, Paul, Norbert W, Peate, Michelle, Phillips, Bob, Reed, Damon R, Tinner, Eva Maria E, van den Berg, Marleen, Verhaak, Chris, Mulder, Renée L, Font-Gonzalez, Anna, Hudson, Melissa M, van Santen, Hanneke M, Loeffen, Erik A H, Burns, Karen C, Quinn, Gwendolyn P, van Dulmen-den Broeder, Eline, Byrne, Julianne, Haupt, Riccardo, Wallace, W Hamish, van den Heuvel-Eibrink, Marry M, Anazodo, Antoinette, Anderson, Richard A, Barnbrock, Anke, Beck, Joern D, Bos, Annelies M E, Demeestere, Isabelle, Denzer, Christian, Di Iorgi, Natascia, Hoefgen, Holly R, Kebudi, Rejin, Lambalk, Cornelis, Langer, Thorsten, Meacham, Lillian R, Rodriguez-Wallberg, Kenny, Stern, Catharyn, Stutz-Grunder, Eveline, van Dorp, Wendy, Veening, Margreet, Veldkamp, Saskia, van der Meulen, Eline, Constine, Louis S, Kenney, Lisa B, van de Wetering, Marianne D, Kremer, Leontien C M, Levine, Jennifer, and Tissing, Wim J E

Published
2021
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14. Fertility preservation for male patients with childhood, adolescent, and young adult cancer: recommendations from the PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group

Author

Berger, Claire, Diesch, Tamara, Giwercman, Aleksander, Grabow, Desiree, Gracia, Clarisa, Hunter, Sarah E, Inthorn, Julia, Kaatsch, Peter, Kelvin, Joanne F, Klosky, James L, Laven, Joop S E, Lockart, Barbara A, Neggers, Sebastian JCMM, Paul, Norbert W, Peate, Michelle, Phillips, Bob, Quinn, Gwendolyn P, Reed, Damon R, Tinner, Eva Maria E, van den Berg, Marleen, Verhaak, Chris, Mulder, Renée L, Font-Gonzalez, Anna, Green, Daniel M, Loeffen, Erik A H, Hudson, Melissa M, Loonen, Jacqueline, Yu, Richard, Ginsberg, Jill P, Mitchell, Rod T, Byrne, Julianne, Skinner, Roderick, Anazodo, Antoinette, Constine, Louis S, de Vries, Andrica, Jahnukainen, Kirsi, Lorenzo, Armando, Meissner, Andreas, Nahata, Leena, Dinkelman-Smit, Marij, Tournaye, Herman, Haupt, Riccardo, van den Heuvel-Eibrink, Marry M, van Santen, Hanneke M, van Pelt, Ans M M, Dirksen, Uta, den Hartogh, Jaap, van Dulmen-den Broeder, Eline, Wallace, W Hamish, Levine, Jennifer, Tissing, Wim J E, Kremer, Leontien C M, Kenney, Lisa B, and van de Wetering, Marianne D

Published
2021
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15. Interindividual variation in ovarian reserve after gonadotoxic treatment in female childhood cancer survivors - a genome-wide association study: results from PanCareLIFE

Author

MS VPG/Gynaecologie, Cancer, Speerpunt, Zorg en O&O, Child Health, van der Perk, M E Madeleine, Broer, Linda, Yasui, Yutaka, Laven, Joop S E, Robison, Leslie L, Tissing, Wim J E, Versluys, Birgitta, Bresters, Dorine, Kaspers, Gertjan J L, Lambalk, Cornelis B, Overbeek, Annelies, Loonen, Jacqueline J, Beerendonk, Catharina C M, Byrne, Julianne, Berger, Claire, Clemens, Eva, van Dulmen-den Broeder, Eline, Dirksen, Uta, van der Pal, Helena J, de Vries, Andrica C H, Winther, Jeanette Falck, Ranft, Andreas, Fosså, Sophie D, Grabow, Desiree, Muraca, Monica, Kaiser, Melanie, Kepák, Tomáš, Kruseova, Jarmila, Modan-Moses, Dalit, Spix, Claudia, Zolk, Oliver, Kaatsch, Peter, Kremer, Leontien C M, Brooke, Russell J, Wang, Fan, Baedke, Jessica L, Uitterlinden, André G, Bos, Annelies M E, van Leeuwen, Flora E, Ness, Kirsten K, Hudson, Melissa M, van der Kooi, Anne-Lotte L F, van den Heuvel-Eibrink, Marry M, PanCareLIFE Consortium, MS VPG/Gynaecologie, Cancer, Speerpunt, Zorg en O&O, Child Health, van der Perk, M E Madeleine, Broer, Linda, Yasui, Yutaka, Laven, Joop S E, Robison, Leslie L, Tissing, Wim J E, Versluys, Birgitta, Bresters, Dorine, Kaspers, Gertjan J L, Lambalk, Cornelis B, Overbeek, Annelies, Loonen, Jacqueline J, Beerendonk, Catharina C M, Byrne, Julianne, Berger, Claire, Clemens, Eva, van Dulmen-den Broeder, Eline, Dirksen, Uta, van der Pal, Helena J, de Vries, Andrica C H, Winther, Jeanette Falck, Ranft, Andreas, Fosså, Sophie D, Grabow, Desiree, Muraca, Monica, Kaiser, Melanie, Kepák, Tomáš, Kruseova, Jarmila, Modan-Moses, Dalit, Spix, Claudia, Zolk, Oliver, Kaatsch, Peter, Kremer, Leontien C M, Brooke, Russell J, Wang, Fan, Baedke, Jessica L, Uitterlinden, André G, Bos, Annelies M E, van Leeuwen, Flora E, Ness, Kirsten K, Hudson, Melissa M, van der Kooi, Anne-Lotte L F, van den Heuvel-Eibrink, Marry M, and PanCareLIFE Consortium

Published
2024

16. The normal and abnormal menstrual cycle

Author

Laven, Joop S. E., Lambalk, Nils B., Steegers, Eric A.P., editor, Fauser, Bart C.J.M., editor, Hilders, Carina G.J.M., editor, Jaddoe, Vincent W.V., editor, Massuger, Leon F.A.G., editor, van der Post, Joris A.M., editor, and Schoenmakers, Sam, editor

Published
2019
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22. OR20-02 Trans-Ethnic Analysis Of PCOS Subtype Genomewide Association Signals Reveals 3 Shared Subtype-Specific Loci

Author

Brewer, Kelly, primary, Sisk, Ryan, additional, Lee, Hyejin, additional, Elisabeth Moolhuijsen, Loes Melanie, additional, van der Ham, Kim, additional, Louwers, Yvonne, additional, Visser, Jenny A, additional, Dapas, Matthew, additional, Franks, Stephen, additional, Laven, Joop S E, additional, Li, Chun, additional, and Dunaif, Andrea Elizabeth, additional

Published
2023
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23. SAT363 The Prevalence And Phenotype Of Polycystic Ovary Syndrome (PCOS) In A Community-Based Population In Sub-Sahara Africa: The Nigeria-PEP Study

Author

Makwe, Christian Chigozie, primary, Olamijulo, Joseph A, additional, Balogun, Mobolanle R, additional, Akinkugbe, Awesha O, additional, Samuel, Aderonke, additional, Udenze, Kristy, additional, Bril, Fernando, additional, Buyalos, Richard P, additional, Laven, Joop S E, additional, and Azziz, Ricardo, additional

Published
2023
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25. Trabecular bone density in middle-aged women with reproductive disorders

Author

van Zwol-Janssens, Charissa, primary, Hage, Aglaia, additional, van der Ham, Kim, additional, Velthuis, Birgitta K, additional, Budde, Ricardo P J, additional, Koster, Maria P H, additional, Franx, Arie, additional, Fauser, Bart C J M, additional, Boersma, Eric, additional, Bos, Daniel, additional, Laven, Joop S E, additional, Louwers, Yvonne V, additional, and _, _, additional

Published
2023
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27. Reference ranges of anti‐Müllerian hormone and interaction with placental biomarkers in early pregnancy:the Generation R Study, a population-based prospective cohort study

Author

Dykgraaf, Ramon H M, Schalekamp-Timmermans, Sarah, Adank, M C, van den Berg, Sjoerd A A, van de Lang-Born, Brigitta M N, Korevaar, Tim Im, Kumar, Ajay, Kalra, Bahnu, Savjani, Gopal V, Steegers, Eric A P, Louwers, Yvonne V, Laven, Joop S E, Dykgraaf, Ramon H M, Schalekamp-Timmermans, Sarah, Adank, M C, van den Berg, Sjoerd A A, van de Lang-Born, Brigitta M N, Korevaar, Tim Im, Kumar, Ajay, Kalra, Bahnu, Savjani, Gopal V, Steegers, Eric A P, Louwers, Yvonne V, and Laven, Joop S E

Abstract

Objective: The primary objective of this study is to establish maternal reference values of anti‐Müllerian hormone (AMH) in a fertile multi-ethnic urban pregnant population and to evaluate the effect of gestational age. The secondary objective of this study is to explore the association between AMH and placental biomarkers. Design: This study was embedded in the Generation R Study, an ongoing population-based prospective cohort study from early pregnancy onwards. Setting: City of Rotterdam, the Netherlands, out of hospital setting. Patients: In 5806 women, serum AMH levels were determined in early pregnancy (median 13.5 weeks; 95% range 10.5–17.2). Intervention(s): None. Main outcome measures: Maternal AMH levels in early pregnancy and its association with placental biomarkers, including human chorionic gonadotrophin (hCG), soluble fms-like tyrosine kinase-1 (sFLT), and placental growth factor (PLGF). Results: A nomogram of AMH in early pregnancy was developed. Serum AMH levels showed a decline with advancing gestational age. Higher AMH levels were associated with a higher level of the placental biomarkers hCG and sFLT in early pregnancy. This last association was predominantly mediated by hCG. AMH levels were negatively associated with PLGF levels. Conclusion: In this large study, we show that AMH levels in early pregnancy decrease with advancing gestational age. The association between AMH and the placental biomarkers hCG, sFLT, and PLGF suggests a better placental development with lower vascular resistance in mothers with higher AMH levels. Hence, AMH might be useful in predicting adverse pregnancy outcomes due to impaired placental development.

Published
2023

32. Individualized versus standard FSH dosing in women starting IVF/ICSI: an RCT. Part 1: The predicted poor responder

Author

van Tilborg, Theodora C, Torrance, Helen L, Oudshoorn, Simone C, Eijkemans, Marinus J C, Koks, Carolien A M, Verhoeve, Harold R, Nap, Annemiek W, Scheffer, Gabrielle J, Manger, A Petra, Schoot, Benedictus C, Sluijmer, Alexander V, Verhoeff, Arie, Groen, Henk, Laven, Joop S E, Mol, Ben Willem J, Broekmans, Frank J M, van Tilborg, Theodora C, Oudshoorn, Simone C, Eijkemans, Marinus J C, Mochtar, Monique H, Koks, Carolien A M, van Golde, Ron J T, Verhoeve, Harold R, Nap, Annemiek W, Scheffer, Gabrielle J, Manger, A Petra, Hoek, Annemieke, Schoot, Bendictus C, Oosterhuis, G Jur E, Kuchenbecker, Walter K H, Fleischer, Kathrin, de Bruin, Jan Peter, Sluijmer, Alexander V, Friederich, Jaap, Verhoeff, Arie, van Hooff, Marcel H A, van Santbrink, Evert J P, Brinkhuis, Egbert A, Smeenk, Jesper M J, Kwee, Janet, de Koning, Corry H, Groen, Henk, van Wely, Madelon, Lambalk, Cornelis B, Laven, Joop S E, Mol, Ben Willem J, Broekmans, Frank J M, and Torrance, Helen L

Published
2017
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33. Individualized FSH dosing based on ovarian reserve testing in women starting IVF/ICSI: a multicentre trial and cost-effectiveness analysis

Author

van Tilborg, Theodora C, Oudshoorn, Simone C, Eijkemans, Marinus J C, Mochtar, Monique H, van Golde, Ron J T, Hoek, Annemieke, Kuchenbecker, Walter K H, Fleischer, Kathrin, de Bruin, Jan Peter, Groen, Henk, van Wely, Madelon, Lambalk, Cornelis B, Laven, Joop S E, Mol, Ben Willem J, Broekmans, Frank J M, Torrance, Helen L, van Tilborg, Theodora C, Oudshoorn, Simone C, Eijkemans, Marinus J C, Mochtar, Monique H, Koks, Carolien A M, van Golde, Ron J T, Verhoeve, Harold R, Nap, Annemiek W, Scheffer, Gabrielle J, Manger, A Petra, Hoek, Annemieke, Schoot, Bendictus C, Oosterhuis, G Jur E., Kuchenbecker, Walter K H, Fleischer, Kathrin, de Bruin, Jan Peter, Sluijmer, Alexander V, Friederich, Jaap, Verhoeff, Arie, van Hooff, Marcel H A, van Santbrink, Evert J P, Brinkhuis, Egbert A, Smeenk, Jesper M J, Kwee, Janet, de Koning, Corry H, Groen, Henk, van Wely, Madelon, Lambalk, Cornelis B, Laven, Joop S E, Mol, Ben Willem J, Broekmans, Frank J M, and Torrance, Helen L

Published
2017
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34. BMJ Open

Author

Evans-Hoeker, Emily, Wang, Zheng, Groen, Henk, Cantineau, Astrid E. P., Thurin-Kjellberg, Ann, Bergh, Christina, Laven, Joop S. E., Dietz De Loos, Alexandra, Jiskoot, Geranne, Baillargeon, Jean-Patrice, Palomba, Stefano, Sim, Kyra, Moran, Lisa J., Espinós, Juan J., Moholdt, Trine, Rothberg, Amy E., Shoupe, Donna, Hoek, Annemieke, Legro, Richard S., Mol, Ben W., and Wang, Rui

Subjects
Comparative Effectiveness Research, Venus-IPD Collaboration, Contraception/Reproduction, Prevention, Clinical Trials and Supportive Activities, Subfertility, Reproductive health and childbirth, Overweight, Cardiovascular, Perinatology, Diet, Stroke, Meta-Analysis as Topic, Clinical Research, Pregnancy, Infertility, Humans, Reproductive medicine, Female, Obesity, Nutrition & dietetics, Exercise, Nutrition, Cancer, Systematic Reviews as Topic
Abstract

Introduction: Dietary and/or physical activity interventions are often recommended for women with overweight or obesity as the first step prior to fertility treatment. However, randomised controlled trials (RCTs) so far have shown inconsistent results. Therefore, we propose this individual participant data meta-analysis (IPDMA) to evaluate the effectiveness and safety of dietary and/or physical activity interventions in women with infertility and overweight or obesity on reproductive, maternal and perinatal outcomes and to explore if there are subgroup(s) of women who benefit from each specific intervention or their combination (treatment-covariate interactions). Methods and analysis: We will include RCTs with dietary and/or physical activity interventions as core interventions prior to fertility treatment in women with infertility and overweight or obesity. The primary outcome will be live birth. We will search MEDLINE, Embase, Cochrane Central Register of Controlled Trials and trial registries to identify eligible studies. We will approach authors of eligible trials to contribute individual participant data (IPD). We will perform risk of bias assessments according to the Risk of Bias 2 tool and a random-effects IPDMA. We will then explore treatment-covariate interactions for important participant-level characteristics. Ethics and dissemination: Formal ethical approval for the project (Venus-IPD) was exempted by the medical ethics committee of the University Medical Center Groningen (METc code: 2021/563, date: 17 November 2021). Data transfer agreement will be obtained from each participating institute/hospital. Outcomes will be disseminated internationally through the collaborative group, conference presentations and peer-reviewed publication. PROSPERO registration number CRD42021266201. Published version

Published
2022

36. Dietary and/or physical activity interventions in women with overweight or obesity prior to fertility treatment: protocol for a systematic review and individual participant data meta-analysis

Author

Evans-Hoeker, Emily, primary, Wang, Zheng, additional, Groen, Henk, additional, Cantineau, Astrid E P, additional, Thurin‐Kjellberg, Ann, additional, Bergh, Christina, additional, Laven, Joop S E, additional, Dietz de Loos, Alexandra, additional, Jiskoot, Geranne, additional, Baillargeon, Jean-Patrice, additional, Palomba, Stefano, additional, Sim, Kyra, additional, Moran, Lisa J, additional, Espinós, Juan J, additional, Moholdt, Trine, additional, Rothberg, Amy E, additional, Shoupe, Donna, additional, Hoek, Annemieke, additional, Legro, Richard S, additional, Mol, Ben W, additional, and Wang, Rui, additional

Published
2022
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37. Gonadotrophins Versus Clomifene Citrate With or Without Intrauterine Insemination in Women With Normogonadotropic Anovulation and Clomifene Failure (M-OVIN): A Randomized, Two-by-Two Factorial Trial

Author

Weiss, Nienke S., Nahuis, Marleen J., Bordewijk, Esmee, Oosterhuis, Jurjen E., Smeenk, Jesper M. J., Hoek, Annemieke, Broekmans, Frank J. M., Fleischer, Kathrin, de Bruin, Jan Peter, Kaaijk, Eugenie M., Laven, Joop S. E., Hendriks, Dave J., Gerards, Marie H., van Rooij, Ilse A. J., Bourdrez, Petra, Gianotten, Judith, Koks, Carolien, Lambalk, Cornelis B., Hompes, Peter G., van der Veen, Fulco, Mol, Ben Willem J., and van Wely, Madelon

Published
2018
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39. Genetic variation in gonadal impairment in female survivors of childhood cancer: a PanCareLIFE study protocol

Author

van der Kooi, Anne-Lotte L. F., Clemens, Eva, Broer, Linda, Zolk, Oliver, Byrne, Julianne, Campbell, Helen, van den Berg, Marleen, Berger, Claire, Calaminus, Gabriele, Dirksen, Uta, Winther, Jeanette Falck, Fosså, Sophie D, Grabow, Desiree, Haupt, Riccardo, Kaiser, Melanie, Kepak, Tomas, Kremer, Leontien, Kruseova, Jarmila, Modan-Moses, Dalit, Ranft, Andreas, Spix, Claudia, Kaatsch, Peter, Laven, Joop S. E., van Dulmen-den Broeder, Eline, Uitterlinden, André G., van den Heuvel-Eibrink, Marry M., and on behalf of the PanCareLIFE Consortium

Published
2018
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41. Dietary and/or physical activity interventions in women with overweight or obesity prior to fertility treatment: protocol for a systematic review and individual participant data meta-analysis

Author

Evans-Hoeker, Emily, Wang, Zheng, Groen, Henk, Cantineau, Astrid E. P., Thurin-Kjellberg, Ann, Bergh, Christina, Laven, Joop S. E., Dietz De Loos, Alexandra, Jiskoot, Geranne, Baillargeon, Jean-Patrice, Palomba, Stefano, Sim, Kyra, Moran, Lisa J., Espinós, Juan J., Moholdt, Trine, Rothberg, Amy E., Shoupe, Donna, Hoek, Annemieke, Legro, Richard S., Mol, Ben W., Wang, Rui, Evans-Hoeker, Emily, Wang, Zheng, Groen, Henk, Cantineau, Astrid E. P., Thurin-Kjellberg, Ann, Bergh, Christina, Laven, Joop S. E., Dietz De Loos, Alexandra, Jiskoot, Geranne, Baillargeon, Jean-Patrice, Palomba, Stefano, Sim, Kyra, Moran, Lisa J., Espinós, Juan J., Moholdt, Trine, Rothberg, Amy E., Shoupe, Donna, Hoek, Annemieke, Legro, Richard S., Mol, Ben W., and Wang, Rui

Abstract

Introduction: Dietary and/or physical activity interventions are often recommended for women with overweight or obesity as the first step prior to fertility treatment. However, randomised controlled trials (RCTs) so far have shown inconsistent results. Therefore, we propose this individual participant data meta-analysis (IPDMA) to evaluate the effectiveness and safety of dietary and/or physical activity interventions in women with infertility and overweight or obesity on reproductive, maternal and perinatal outcomes and to explore if there are subgroup(s) of women who benefit from each specific intervention or their combination (treatment-covariate interactions). Methods and analysis: We will include RCTs with dietary and/or physical activity interventions as core interventions prior to fertility treatment in women with infertility and overweight or obesity. The primary outcome will be live birth. We will search MEDLINE, Embase, Cochrane Central Register of Controlled Trials and trial registries to identify eligible studies. We will approach authors of eligible trials to contribute individual participant data (IPD). We will perform risk of bias assessments according to the Risk of Bias 2 tool and a random-effects IPDMA. We will then explore treatment-covariate interactions for important participant-level characteristics. Ethics and dissemination: Formal ethical approval for the project (Venus-IPD) was exempted by the medical ethics committee of the University Medical Center Groningen (METc code: 2021/563, date: 17 November 2021). Data transfer agreement will be obtained from each participating institute/hospital. Outcomes will be disseminated internationally through the collaborative group, conference presentations and peer-reviewed publication. PROSPERO registration number CRD42021266201.

Published
2022

42. Sex steroids and sex steroid-binding globulin levels amongst middle-aged and elderly men and women from general population

Author

Aribas, Elif, van Lennep, Jeanine E. Roeters, De Rijke, Yolanda B., Laven, Joop S. E., Ikram, Mohammad Arfan, Peeters, Robin P., Kavousi, Maryam, Aribas, Elif, van Lennep, Jeanine E. Roeters, De Rijke, Yolanda B., Laven, Joop S. E., Ikram, Mohammad Arfan, Peeters, Robin P., and Kavousi, Maryam

Abstract

Background and Aims Availability of age- and sex-specific reference values for sex steroids and sex steroid-binding globulin (SHBG) levels allows for appropriate interpretation of research findings and their clinical applications. We report the sex-specific distribution and reference levels of sex steroids, including total estradiol, total testosterone and (calculated) free androgen index (cFAI), SHBG and other androgens dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulphate (DHEAS) and androstenedione across age. Methods Using data from 3291 participants from the prospective population-based Rotterdam Study (2006-2008), we visualised the distribution of sex steroids and SHBG levels by calculating and depicting the 5th, 25th, 50th, 75th and 95th percentiles per year and per age-year across 5-year age bands to provide reference value ranges in men and women. Total estradiol and SHBG were measured using automated immunoassay and androgens using liquid chromatography-mass spectrometry (LC-MS/MS). Result Mean age was 56.8 (range 45.6-79.9) years in men and 56.9 (range 45.7-79.9) years in women. Amongst men, total estradiol and SHBG showed an increasing trend from 45 years onwards. In women, total estradiol and SHBG showed a decreasing trend from 45 years until the age of 60. From 60 years onwards, SHBG showed an increasing trend. For total testosterone, a clear declining trend was observed amongst men but not women. Other androgens showed a similar decreasing trend in both sexes from 45 years onwards. Discussion and Conclusion Our study underlines sex-specific trends in sex steroids and SHBG levels with ageing. This warrants taking into account sex- and age-specific reference values for sex steroids and SHBG when investigating their impact on health outcomes to prevent controversial results and allow for their appropriate clinical application.

Published
2022

43. Individualized versus standard FSH dosing in women starting IVF/ICSI: an RCT. Part 2: The predicted hyper responder

Author

Oudshoorn, Simone C, van Tilborg, Theodora C, Eijkemans, Marinus J C, Oosterhuis, G Jur E, Friederich, Jaap, van Hooff, Marcel H A, van Santbrink, Evert J P, Brinkhuis, Egbert A, Smeenk, Jesper M J, Kwee, Janet, de Koning, Corry H, Groen, Henk, Lambalk, Cornelis B, Mol, Ben Willem J, Broekmans, Frank J M, Torrance, Helen L, van Tilborg, Theodora C, Oudshoorn, Simone C, Eijkemans, Marinus J C, Mochtar, Monique H, Koks, Carolien A M, van Golde, Ron J T, Verhoeve, Harold R, Nap, Annemiek W, Scheffer, Gabrielle J, Manger, A Petra, Hoek, Annemieke, Schoot, Bendictus C, Oosterhuis, G Jur E, Kuchenbecker, Walter K H, Fleischer, Kathrin, de Bruin, Jan Peter, Sluijmer, Alexander V, Friederich, Jaap, Verhoeff, Arie, van Hooff, Marcel H A, van Santbrink, Evert J P, Brinkhuis, Egbert A, Smeenk, Jesper M J, Kwee, Janet, de Koning, Corry H, Groen, Henk, van Wely, Madelon, Lambalk, Cornelis B, Laven, Joop S E, Mol, Ben Willem J, Broekmans, Frank J M, and Torrance, Helen L

Published
2017
Full Text
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46. Additional file 3 of Longitudinal surface measurements of human blastocysts show that the dynamics of blastocoel expansion are associated with fertilization method and ongoing pregnancy

Author

van Marion, Eva S., Chavli, Effrosyni A., Laven, Joop S. E., Steegers-Theunissen, R��gine P. M., Koster, Maria P. H., and Baart, Esther B.

Abstract

Additional file 3. Linearmixed model analysis of blastocyst expansion surface measurementsover time and the expansion rate, of freshembryo transfers (SET and DET resulting in either noimplantationor implantation of both embryos) compared between no pregnancy and biochemicalpregnancy.

Published
2022
Full Text
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47. Additional file 4 of Longitudinal surface measurements of human blastocysts show that the dynamics of blastocoel expansion are associated with fertilization method and ongoing pregnancy

Author

van Marion, Eva S., Chavli, Effrosyni A., Laven, Joop S. E., Steegers-Theunissen, R��gine P. M., Koster, Maria P. H., and Baart, Esther B.

Abstract

Additional file 4. Linear mixed model analysis of blastocystexpansion surface measurements over time compared between different ovarianstimulation protocols and different culture media.

Published
2022
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48. Additional file 2 of Longitudinal surface measurements of human blastocysts show that the dynamics of blastocoel expansion are associated with fertilization method and ongoing pregnancy

Author

van Marion, Eva S., Chavli, Effrosyni A., Laven, Joop S. E., Steegers-Theunissen, R��gine P. M., Koster, Maria P. H., and Baart, Esther B.

Abstract

Additional file 2. Baselinecharacteristics of cycles of fresh embryo transfers (SET and DETresulting in either no ongoing pregnancy or atwin ongoing pregnancy).

Published
2022
Full Text
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49. Additional file 1 of Longitudinal surface measurements of human blastocysts show that the dynamics of blastocoel expansion are associated with fertilization method and ongoing pregnancy

Author

van Marion, Eva S., Chavli, Effrosyni A., Laven, Joop S. E., Steegers-Theunissen, R��gine P. M., Koster, Maria P. H., and Baart, Esther B.

Subjects
animal structures, embryonic structures
Abstract

Additional file 1. Baselinecharacteristics and treatment outcomes of excluded cycles (cycleswithout embryos that reached the fullblastocyst stage).

Published
2022
Full Text
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50. Additional file 5 of Longitudinal surface measurements of human blastocysts show that the dynamics of blastocoel expansion are associated with fertilization method and ongoing pregnancy

Author

van Marion, Eva S., Chavli, Effrosyni A., Laven, Joop S. E., Steegers-Theunissen, R��gine P. M., Koster, Maria P. H., and Baart, Esther B.

Abstract

Additional file 5. Linear mixed model analysis of blastocystexpansion surface measurements over time and expansion rate, of fresh embryotransfers (SET and DET resulting in either no ongoing pregnancy or a twinongoing pregnancy) compared between IVF, ICSI with ejaculated sperm andTESE-ICSI.

Published
2022
Full Text
View/download PDF

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