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141 results on '"Lavallee, M."'

5. Cognitive Digital Biomarkers from Automated Transcription of Spoken Language

Author

Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory, Tavabi, N., Stück, D., Signorini, A., Karjadi, C., Hanai, T. A., Sandoval, M., Lemke, C., Glass, J., Hardy, S., Lavallee, M., Wasserman, B., Ang, T. F. A., Nowak, C. M., Kainkaryam, R., Foschini, L., Au, Rhoda, Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory, Tavabi, N., Stück, D., Signorini, A., Karjadi, C., Hanai, T. A., Sandoval, M., Lemke, C., Glass, J., Hardy, S., Lavallee, M., Wasserman, B., Ang, T. F. A., Nowak, C. M., Kainkaryam, R., Foschini, L., and Au, Rhoda

Abstract

Background Although patients with Alzheimer’s disease and other cognitive-related neurodegenerative disorders may benefit from early detection, development of a reliable diagnostic test has remained elusive. The penetration of digital voice-recording technologies and multiple cognitive processes deployed when constructing spoken responses might offer an opportunity to predict cognitive status. Objective To determine whether cognitive status might be predicted from voice recordings of neuropsychological testing Design Comparison of acoustic and (para)linguistic variables from low-quality automated transcriptions of neuropsychological testing (n = 200) versus variables from high-quality manual transcriptions (n = 127). We trained a logistic regression classifier to predict cognitive status, which was tested against actual diagnoses. Setting Observational cohort study. Participants 146 participants in the Framingham Heart Study. Measurements Acoustic and either paralinguistic variables (e.g., speaking time) from automated transcriptions or linguistic variables (e.g., phrase complexity) from manual transcriptions. Results Models based on demographic features alone were not robust (area under the receiver-operator characteristic curve [AUROC] 0.60). Addition of clinical and standard acoustic features boosted the AUROC to 0.81. Additional inclusion of transcription-related features yielded an AUROC of 0.90. Conclusions The use of voice-based digital biomarkers derived from automated processing methods, combined with standard patient screening, might constitute a scalable way to enable early detection of dementia.

Published
2022

6. Evaluating the performance of temporal pattern discovery: new application using statins and rhabdomyolysis in OMOP databases

Author

Asiimwe A, Golozar A, Yu T, Bosco C, Hemelrijck Mv, Evans L, and Lavallee M

Subjects
Databases, Factual, Drug-Related Side Effects and Adverse Reactions, Computer science, business.industry, Health Policy, Computer applications to medicine. Medical informatics, R858-859.7, Statins, Health Informatics, Computational biology, medicine.disease, Rhabdomyolysis, Computer Science Applications, Text mining, Adverse events, Temporal pattern discover, medicine, Adverse Drug Reaction Reporting Systems, Electronic Health Records, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, business, Research Article
Abstract

Background Temporal pattern discovery (TPD) is a method of signal detection using electronic healthcare databases, serving as an alternative to spontaneous reporting of adverse drug events. Here, we aimed to replicate and optimise a TPD approach previously used to assess temporal signals of statins with rhabdomyolysis (in The Health Improvement Network (THIN) database) by using the OHDSI tools designed for OMOP data sources. Methods We used data from the Truven MarketScan US Commercial Claims and the Commercial Claims and Encounters (CCAE). Using an extension of the OHDSI ICTemporalPatternDiscovery package, we ran positive and negative controls through four analytical settings and calculated sensitivity, specificity, bias and AUC to assess performance. Results Similar to previous findings, we noted an increase in the Information Component (IC) for simvastatin and rhabdomyolysis following initial exposure and throughout the surveillance window. For example, the change in IC was 0.266 for the surveillance period of 1–30 days as compared to the control period of − 180 to − 1 days. Our modification of the existing OHDSI software allowed for faster queries and more efficient generation of chronographs. Conclusion Our OMOP replication matched the we can account forwe can account for of the original THIN study, only simvastatin had a signal. The TPD method is a useful signal detection tool that provides a single statistic on temporal association and a graphical depiction of the temporal pattern of the drug outcome combination. It remains unclear if the method works well for rare adverse events, but it has been shown to be a useful risk identification tool for longitudinal observational databases. Future work should compare the performance of TPD with other pharmacoepidemiology methods and mining techniques of signal detection. In addition, it would be worth investigating the relative TPD performance characteristics using a variety of observational data sources.

Published
2022

18. Internalization and trafficking of neurotensin via NTS3 receptors in HT29 cells

Author

Morinville, A., Martin, S., Lavallee, M., Vincent, J.-P., Beaudet, A., Mazella, J., Institut de pharmacologie moléculaire et cellulaire (IPMC), Université Nice Sophia Antipolis (... - 2019) (UNS), and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)

Published
2004

36. Ecological value of Bem's gender schema theory explored through females' traditional and...

Author

Lavallee, M. and Pelletier, R.

Subjects
*PSYCHOLOGY
Abstract

Discusses a study which aimed to verify the ecological adequateness of Bem's gender schema theory by evaluating four female samples, their occupations, and the nature of their occupations' settings. Traditional vs. nontraditional; Hypothesis; French adaptation of the Bem Sex-Role Inventory; Gender-schematic categories identified; Male-oriented activities; Implications; Method; Results and discussion; More.

Published
1992

37. Effects of Coronary Artery Reperfusion on Recovery of Regional Myocardial Function In Conscious Dogs.

Author

Lavallee, M., Cox, D. A., and Vatner, S. F.

Abstract

The effects of coronary artery occlusion and reperfusion at 1 h (1-h group), 2 h (2-h group) and 3-h (3-h group) were compared with a permanently occluded group (P group) on measurements of overall left ventricular (LV) and regional endocardial function over a 4-wk period. The experiments were conducted in conscious dogs 1–3 wk after recovery from instrumentation with solid-state LV pressure gauges, aortic and left atrial catheters, hydraulic occluders and Doppler flow transducers on the left circumflex coronary artery, and multiple pairs of ultrasonic transducers implanted in the endocardial third of the LV free wall to measure endocardial segment shortening. During coronary artery occlusion, similar haemodynamic effects were observed in each of the four groups. At 1 h after coronary artery occlusion, systolic shortening was depressed by over 100%. In the P group, systolic shortening remained depressed by 86 ± 6·8% 4 wk later. Considerable return of function occurred in the 1-h group—i.e., shortening remained depressed by only 30 ± 7·4%. Systolic shortening remained depressed by 58 ± 9·1% in the 2-h group and by 78 ± 5·6% in the 3-h group. Thus, in the conscious dog, coronary artery reperfusion at 1h after coronary artery occlusion results in substantial return of endocardial function in the most severely ischaemic myocardium. However, after 3 h of coronary artery occlusion, little salvage of regional endocardial myocardial function can be induced by acute reperfusion in this model. [ABSTRACT FROM PUBLISHER]

Published
1985
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38. Bicycles in the Attack.

Author

LaVallee, M. P.

Subjects
MILITARY cycling, INFANTRY, SUSTAINABILITY, TRANSPORTATION
Abstract

The article offers information on the usage of cargo bicycles to support light infantry operations by the U.S. Marine Corps in Afghanistan. The author discusses the bicycle's capacity, mobility, and sustainability. Moreover, he concludes that cargo bicycles provide unique capabilities that complement the equipment to meet transportation needs in austere environments.

Published
2010

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