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1. Characteristics and Prognosis Factors of Pneumocystis jirovecii Pneumonia According to Underlying Disease: A Retrospective Multicenter Study

Author

Raffi, Francois, Boutoille, David, Biron, Charlotte, Lefebvre, Maeva, Gaborit, Benjamin Jean, Le Turnier, Paul, Deschanvres, Colin, Lecomte, Raphael, Chauveau, Marie, Lécuyer, Romain, Asquier-Khati, Antoine, Le Pape, Patrice, Morio, Florent, Lavergne, Rose-Anne, Jeddi, Fakhri, Corvec, Stéphane, Bemer, Pascale, Caillon, Jocelyne, Guillouzouic, Aurélie, Leroy, Anne-Gaëlle, Lakhal, Karim, Cinotti, Raphaël, Roquilly, Antoine, Emmanuel Canet, Jean Reignier, Blanc, François Xavier, Bretonniere, Cédric, Morin, Paul, Camou, Fabrice, Issa, Nahéma, Guisset, Olivier, Mourissoux, Gaelle, Accoceberry, Isabelle, Gabriel, Frederic, Coron, Noémie, Delhaes, Laurence, Imbert, Sébastien, Lefranc, Maxime, Lussac-Sorton, Florian, Rougeron, Amandine, Gousseff, Marie, Crabol, Yoann, Corvaisier, Grégory, Lautredoux, Florent, Cady, Anne, Auger, Myriam, Pouedras, Pascal, Lavergne, Rose-anne, Canet, Emmanuel, Raffi, François, Néel, Antoine, Tessoulin, Benoît, and Gaborit, Benjamin

Published
2024
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2. Should we reconsider Pneumocystis pneumonia presentation and treatment according to its underlying disease? An unsupervised cluster analysis of a retrospective multicentre study

Author

Gaborit, Benjamin, primary, Lécuyer, Romain, additional, Issa, Nahéma, additional, Camou, Fabrice, additional, Lavergne, Rose-anne, additional, Gabriel, Frederic, additional, Morio, Florent, additional, Canet, Emmanuel, additional, Raffi, François, additional, Boutoille, David, additional, Cady, Anne, additional, Gousseff, Marie, additional, Crabol, Yoann, additional, Néel, Antoine, additional, Tessoulin, Benoît, additional, Raffi, Francois, additional, Biron, Charlotte, additional, Lefebvre, Maeva, additional, Le Turnier, Paul, additional, Deschanvres, Colin, additional, Lecomte, Raphael, additional, Chauveau, Marie, additional, Asquier-Khati, Antoine, additional, Pineau, Valentin, additional, Prime, Marie, additional, Delaunay, Clarisse, additional, Essid, Hakim, additional, Le Pape, Patrice, additional, Jeddi, Fakhri, additional, Corvec, Stéphane, additional, Bemer, Pascale, additional, Caillon, Jocelyne, additional, Guillouzouic, Aurélie, additional, Leroy, Anne-Gaëlle, additional, Lakhal, Karim, additional, Cinotti, Raphaël, additional, Roquilly, Antoine, additional, Vourc’h, Mickael, additional, Reignier, Jean, additional, Blanc, François Xavier, additional, Bretonniere, Cédric, additional, Morin, Jean, additional, Le Blanc, Camille, additional, Alami, Hakim, additional, Guisset, Olivier, additional, Mourissoux, Gaelle, additional, Accoceberry, Isabelle, additional, Coron, Noémie, additional, Delhaes, Laurence, additional, Imbert, Sébastien, additional, Lefranc, Maxime, additional, Lussac-Sorton, Florian, additional, Rougeron, Amandine, additional, Corvaisier, Grégory, additional, Lautredoux, Florent, additional, Auger, Myriam, additional, and Pouedras, Pascal, additional

Published
2024
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4. Should We Reconsider PneumocystisPneumonia Presentation and Treatment According to Its Underlying Disease?

Author

Gaborit, Benjamin, Lécuyer, Romain, Issa, Nahéma, Camou, Fabrice, Lavergne, Rose-anne, Gabriel, Frederic, Morio, Florent, Canet, Emmanuel, Raffi, François, Boutoille, David, Cady, Anne, Gousseff, Marie, Crabol, Yoann, Néel, Antoine, Tessoulin, Benoît, Raffi, Francois, Boutoille, David, Biron, Charlotte, Lefebvre, Maeva, Gaborit, Benjamin Jean, Le Turnier, Paul, Deschanvres, Colin, Lecomte, Raphael, Chauveau, Marie, Lécuyer, Romain, Asquier-Khati, Antoine, Pineau, Valentin, Prime, Marie, Delaunay, Clarisse, Essid, Hakim, Le Pape, Patrice, Morio, Florent, Lavergne, Rose-Anne, Jeddi, Fakhri, Corvec, Stéphane, Bemer, Pascale, Caillon, Jocelyne, Guillouzouic, Aurélie, Leroy, Anne-Gaëlle, Lakhal, Karim, Cinotti, Raphaël, Roquilly, Antoine, Jean Reignier, Mickael Vourc’h;, Canet, Emmanuel, Blanc, François Xavier, Bretonniere, Cédric, Morin, Jean, Le Blanc, Camille, Alami, Hakim, Camou, Fabrice, Issa, Nahéma, Guisset, Olivier, Mourissoux, Gaelle, Accoceberry, Isabelle, Gabriel, Frederic, Coron, Noémie, Delhaes, Laurence, Imbert, Sébastien, Lefranc, Maxime, Lussac-Sorton, Florian, Rougeron, Amandine, Gousseff, Marie, Crabol, Yoann, Corvaisier, Grégory, Lautredoux, Florent, Anne Cady, Romain Lécuyerand, Auger, Myriam, and Pouedras, Pascal

Published
2024
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5. Should We Reconsider Pneumocystis Pneumonia Presentation and Treatment According to Its Underlying Disease?: An Unsupervised Cluster Analysis of a Retrospective Multicenter Study

Author

Raffi, Francois, Boutoille, David, Biron, Charlotte, Lefebvre, Maeva, Gaborit, Benjamin Jean, Le Turnier, Paul, Deschanvres, Colin, Lecomte, Raphael, Chauveau, Marie, Lécuyer, Romain, Asquier-Khati, Antoine, Pineau, Valentin, Prime, Marie, Delaunay, Clarisse, Essid, Hakim, Le Pape, Patrice, Morio, Florent, Lavergne, Rose-Anne, Jeddi, Fakhri, Corvec, Stéphane, Bemer, Pascale, Caillon, Jocelyne, Guillouzouic, Aurélie, Leroy, Anne-Gaëlle, Lakhal, Karim, Cinotti, Raphaël, Roquilly, Antoine, Jean Reignier, Mickael Vourc’h, Canet, Emmanuel, Blanc, François Xavier, Bretonniere, Cédric, Morin, Jean, Le Blanc, Camille, Alami, Hakim, Camou, Fabrice, Issa, Nahéma, Guisset, Olivier, Mourissoux, Gaelle, Accoceberry, Isabelle, Gabriel, Frederic, Coron, Noémie, Delhaes, Laurence, Imbert, Sébastien, Lefranc, Maxime, Lussac-Sorton, Florian, Rougeron, Amandine, Gousseff, Marie, Crabol, Yoann, Corvaisier, Grégory, Lautredoux, Florent, Anne Cady, Romain Lécuyerand, Auger, Myriam, Pouedras, Pascal, Gaborit, Benjamin, Lavergne, Rose-anne, Raffi, François, Cady, Anne, Néel, Antoine, and Tessoulin, Benoît

Published
2024
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7. Characteristics and Prognosis Factors of Pneumocystis jiroveciiPneumonia According to Underlying Disease

Author

Lécuyer, Romain, Issa, Nahéma, Camou, Fabrice, Lavergne, Rose-anne, Gabriel, Frederic, Morio, Florent, Canet, Emmanuel, Raffi, François, Boutoille, David, Cady, Anne, Gousseff, Marie, Crabol, Yoann, Néel, Antoine, Tessoulin, Benoît, Gaborit, Benjamin, Raffi, Francois, Boutoille, David, Biron, Charlotte, Lefebvre, Maeva, Gaborit, Benjamin Jean, Le Turnier, Paul, Deschanvres, Colin, Lecomte, Raphael, Chauveau, Marie, Lécuyer, Romain, Asquier-Khati, Antoine, Le Pape, Patrice, Morio, Florent, Lavergne, Rose-Anne, Jeddi, Fakhri, Corvec, Stéphane, Bemer, Pascale, Caillon, Jocelyne, Guillouzouic, Aurélie, Leroy, Anne-Gaëlle, Lakhal, Karim, Cinotti, Raphaël, Roquilly, Antoine, Emmanuel Canet, Jean Reignier, Blanc, François Xavier, Bretonniere, Cédric, Morin, Paul, Camou, Fabrice, Issa, Nahéma, Guisset, Olivier, Mourissoux, Gaelle, Accoceberry, Isabelle, Gabriel, Frederic, Accoceberry, Isabelle, Coron, Noémie, Delhaes, Laurence, Imbert, Sébastien, Lefranc, Maxime, Lussac-Sorton, Florian, Rougeron, Amandine, Gousseff, Marie, Crabol, Yoann, Corvaisier, Grégory, Lautredoux, Florent, Lécuyer, Romain, Cady, Anne, Auger, Myriam, and Pouedras, Pascal

Abstract

Pneumocystis jiroveciipneumonia (PcP) remains associated with high rates of mortality, and the impact of immunocompromising underlying disease on the clinical presentation, severity, and mortality of PcP has not been adequately evaluated.

Published
2024
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8. Immunoglobulin Abnormalities in Gaucher Disease: an Analysis of 278 Patients Included in the French Gaucher Disease Registry.

Author

Nguyen, Yann, Stirnemann, Jérôme, Lautredoux, Florent, Cador, Bérengère, Bengherbia, Monia, Yousfi, Karima, Hamroun, Dalil, Astudillo, Leonardo, Billette de Villemeur, Thierry, Brassier, Anaïs, Camou, Fabrice, Dalbies, Florence, Dobbelaere, Dries, Gaches, Francis, Leguy-Seguin, Vanessa, Masseau, Agathe, Pers, Yves-Marie, Pichard, Samia, Serratrice, Christine, and Berger, Marc G.

Subjects
MEDICAL registries, GAUCHER'S disease, HEMATOLOGIC malignancies, MULTIPLE myeloma, LYSOSOMAL storage diseases, MYASTHENIA gravis, LYSOSOMES, LEUKAPHERESIS
Abstract

Gaucher disease (GD) is a rare lysosomal autosomal-recessive disorder due to deficiency of glucocerebrosidase; polyclonal gammopathy (PG) and/or monoclonal gammopathy (MG) can occur in this disease. We aimed to describe these immunoglobulin abnormalities in a large cohort of GD patients and to study the risk factors, clinical significance, and evolution. Data for patients enrolled in the French GD Registry were studied retrospectively. The risk factors of PG and/or MG developing and their association with clinical bone events and severe thrombocytopenia, two markers of GD severity, were assessed with multivariable Cox models and the effect of GD treatment on gammaglobulin levels with linear/logarithmic mixed models. Regression of MG and the occurrence of hematological malignancies were described. The 278 patients included (132 males, 47.5%) were followed up during a mean (SD) of 19 (14) years after GD diagnosis. PG occurred in 112/235 (47.7%) patients at GD diagnosis or during follow-up and MG in 59/187 (31.6%). Multivariable analysis retained age at GD diagnosis as the only independent risk factor for MG (> 30 vs. ≤30 years, HR 4.71, 95%CI [2.40–9.27]; p < 0.001). Risk of bone events or severe thrombocytopenia was not significantly associated with PG or MG. During follow-up, non-Hodgkin lymphoma developed in five patients and multiple myeloma in one. MG was observed in almost one third of patients with GD. Immunoglobulin abnormalities were not associated with the disease severity. However, prolonged surveillance of patients with GD is needed because hematologic malignancies may occur. [ABSTRACT FROM AUTHOR]

Published
2020
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