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Researchers from Nestle Research in Lausanne, Switzerland, conducted a study on the use of dielectric barrier discharge ionization (DBDI) as an alternative soft ionization technique for the quantitative determination of fluorotelomer alcohols (FTOHs) and acrylates (FTACs) in environmental, biological, or food samples by gas chromatography-mass spectrometry. The study found that GC-DBDI-HRMS provided dominant molecular adducts for the compounds, offering potential for method development applicable to various materials. The research, published in Microchemical Journal, confirmed structure assignments using stable isotope-labeled analogs and concluded that there is room for further method development in analyzing polyfluoroalkyl substances (PFAS) in different sample types. [Extracted from the article]

A recent study conducted by the Nestle Institute of Health Sciences in Lausanne, Switzerland, focused on the impact of nicotinamide and pyridoxine on muscle stem cell expansion and regenerative capacity during aging. The research found that these natural molecules from food can stimulate muscle stem cells and enhance muscle regeneration, potentially addressing age-related muscle decline. The study suggests that a combination of nicotinamide and pyridoxine could serve as a new nutritional intervention to improve muscle health and function in aging individuals. [Extracted from the article]

A recent study conducted at the Swiss Federal Institute of Technology Lausanne (EPFL) focused on programming the Scalable Optical Learning Operator with spatial-spectral optimization to address issues related to memory transfer and high energy consumption in electronic computers. The research, funded by various organizations including the Swiss National Science Foundation and Google-EPFL Collaboration Grant, demonstrated that optical techniques could offer higher speed and reduced energy consumption compared to electronic counterparts. By utilizing a combination of front-end and spatial-spectral programming, the study achieved an 89.9% classification accuracy on a dataset of chest X-ray images from COVID-19 patients, while significantly reducing the number of tunable parameters. The research concluded that the performance of the programmed SOLO system was comparable to cutting-edge electronic computing platforms with fewer electronic operations. [Extracted from the article]

A study conducted at Lausanne University Hospital in Switzerland identified 23 competencies necessary for generalist nurses to care for sick children and their families in hospital and home-care settings. The competencies were developed through a 3-round Delphi e-survey involving 129 and 132 participants. The study highlighted the importance of competencies such as Advocacy and Moral Agency, Diversity Families Responsiveness, Collaboration, and Clinical Judgment and Inquiry in providing appropriate and safe care to pediatric patients. This research aims to enhance nursing undergraduate programs in Switzerland and beyond to better prepare nurses for pediatric care. [Extracted from the article]

A recent study conducted in Lausanne, Switzerland, focused on the diagnostic features of paediatric myelodysplastic syndrome with UBTF-internal tandem duplication (UBTF-TD). The research highlighted the unique histopathological characteristics observed in bone marrow biopsies of 14 paediatric MDS patients with UBTF-TD, including hypercellularity, dysplasia, and specific abnormalities in hematopoietic lineages. The findings suggest the importance of genetic testing to confirm UBTF aberrations and identify potential genetic alterations, aiming to improve treatment approaches for high-risk paediatric MDS patients. This peer-reviewed research contributes to a better understanding of the disease mechanism and may lead to more targeted therapies for affected individuals. [Extracted from the article]

A recent study conducted at the University of Lausanne Hospital in Switzerland focused on the impact of respiratory illnesses and airborne diseases on Swiss mortality between the 16th and 21st centuries. The research utilized an innovative multidisciplinary approach to analyze historical, demographical, statistical, medical, and bioarchaeological data to understand the social and environmental factors influencing the risk of respiratory diseases. The study highlighted the effects of industrialization on respiratory health in perialpine populations and emphasized the importance of considering past respiratory health dynamics for future management strategies. The results of the study may be valuable for scholars, clinicians, and health policymakers addressing respiratory health challenges in the context of global urbanization. [Extracted from the article]

Researchers from the Swiss Federal Institute of Technology Lausanne have explored the potential of type 2 cytokine Fc-IL-4 in revitalizing exhausted CD8+ T cells against cancer. Their study suggests that Fc-IL-4 can enhance the antitumor efficacy of type 1 immunity-centric therapies and induce durable remission in various tumor models. By modulating metabolic pathways, Fc-IL-4 shows promise as a potent immunotherapy that synergizes with type 1 immunity for long-lasting responses against cancer. This research sheds light on the synergy between different immune responses and offers an innovative strategy for advancing next-generation cancer immunotherapy. [Extracted from the article]

The University of Lausanne (UNIL) has developed a 3-arm on-demand open Dexter Robotic System that combines the precision of robot-assisted surgery with the flexibility of laparoscopy. This system allows for seamless switching between robotic and laparoscopic approaches during procedures, providing advantages for different types of surgical steps. Clinical experience with this system has shown safety and feasibility for right colonic resections and ventral mesh rectopexies. The research has been peer-reviewed and offers insights into the potential benefits of on-demand robotics in surgical procedures. [Extracted from the article]

A recent study conducted by the Nestle Institute of Health Sciences in Switzerland aimed to develop a nutrient-based score to assess the nutritional balance of meals consumed by Filipino adults. The score, based on nutrient composition data, was applied to over 69,000 meals reported by Filipino adults aged 20 to 59. Results showed that meals designed by local nutrition experts scored higher in nutritional quality compared to meals reported by survey participants. The study suggests that this scoring system could potentially help users identify nutritionally balanced meals. [Extracted from the article]

A recent study conducted at the University of Lausanne Hospital in Switzerland examined the prevalence of modifiable cardiovascular risk factors among young adults hospitalized with acute coronary syndromes (ACS) between 2000 and 2019. The research found that young ACS patients in Switzerland had a high prevalence of risk factors, with smoking being the most prevalent, followed by dyslipidemia, hypertension, obesity, and diabetes. The study highlighted a significant increase in the prevalence of hypertension and obesity among young ACS patients over the 20-year period, emphasizing the need for public health initiatives targeting risk factors in young adults in Switzerland. [Extracted from the article]

A recent report from the University of Lausanne discusses new research findings on the molecular basis of sleep dysfunctions in neurological diseases, focusing on the modulation of the SREBP metabolic axis in Drosophila. The study identifies a mechanism that affects sleep homeostasis by altering the NADP+/NADPH ratio, leading to disturbances in sleep patterns. The research suggests that targeting the SREBP metabolic axis could be a potential therapeutic avenue for addressing sleep disorders. For more information, readers can refer to the article "Srebp Modulates the Nadp+/nadph Cycle To Control Night Sleep In drosophila" published in Nature Communications. [Extracted from the article]

A recent study conducted by the University of Lausanne in Switzerland examined the stress responses of mothers and infants following traumatic childbirth. The research found that while mothers and infants reported subjective stress, their physiological stress responses were limited. The study focused on the impact of childbirth-related posttraumatic stress symptoms (CB-PTSD symptoms) on mother-infant synchrony and stress responses. This peer-reviewed research sheds light on the complex interplay between psychological and physiological stress responses in mothers and infants after traumatic childbirth. [Extracted from the article]

A recent study conducted by Lausanne University Hospital and University of Lausanne in Switzerland explored mental health professionals' perceptions and attitudes towards seclusion in psychiatric units. The research found that while many professionals believed seclusion had therapeutic benefits, they also acknowledged its potential negative effects and dangers for patients. Additionally, there was a consensus that seclusion increased the overall feeling of safety, but concerns were raised about the clarity of the Swiss legal framework regulating seclusion. The study highlighted the complex challenges that mental health professionals face in utilizing seclusion and emphasized the need for careful guidance from competent authorities to ensure high-quality care when implementing this coercive measure. [Extracted from the article]

Researchers at the University of Lausanne conducted a study on the effects of a 72-hour abstinence from Instant Messaging (IM) on craving, withdrawal, and affect among undergraduates who regularly engaged in IM. The results showed a decrease in craving and negative affect during and after the abstinence period, while withdrawal-like symptoms and positive affect remained stable. The study suggests that short-term abstinence from IM may reduce preoccupation with its use and lower negative affect, supporting recommendations for users experiencing negative affect states. Further research is needed to explore strategies to support users in regulating their digital device use. [Extracted from the article]

A recent study conducted by the University of Lausanne focused on the mental health of young talented football players in Africa, highlighting the prevalence of anxiety and depressive symptoms among these athletes. The research, supported by FIFA, aimed to address the lack of attention and tailored support for mental health issues in young African players. The study identified three profiles of mental health conditions, emphasizing the need for increased awareness and targeted interventions in this population. [Extracted from the article]

A study conducted at University Hospital Center in Lausanne, Switzerland, focused on the long-term outcomes of children with unilateral cleft lip and palate (uCLP) who underwent the Malek surgical technique. The research found that while the Malek procedure was associated with a high risk of fistula, it resulted in good long-term phonatory outcomes. The study included a retrospective review of 79 cases, with 20% of children undergoing a Le Fort procedure and one-third requiring secondary lip surgery and rhinoplasty. This research was published in The Cleft Palate Craniofacial Journal and has been peer-reviewed. [Extracted from the article]

Researchers at the University of Lausanne have conducted a study on the glucagon-like peptide-1 receptor (GLP-1R) and its role in regulating blood glucose levels and food intake. The study revisited a classic article from 1993 by Thorens et al., which provided insights into the cloning, sequencing, and functional expression of the human GLP-1R. This research has implications for the treatment of type 2 diabetes and obesity therapy, with financial support from various organizations. The findings have been published in the journal Diabetes and are available for further exploration. [Extracted from the article]

A study conducted at the University of Lausanne Hospital in Switzerland examined the quantitative and functional changes in platelets and fibrinogen following cardiopulmonary bypass (CPB) in children with congenital heart diseases. The research found that platelet count, fibrinogen concentration, and their activities decreased after CPB, with the duration of CPB directly linked to reductions in platelet count and fibrinogen level. The study concluded that post-CPB coagulopathy is multifactorial and involves functional changes in coagulation cascade components, particularly affecting young children, patients requiring prolonged CPB surgery, or those experiencing hypothermia. [Extracted from the article]

The research study from the Center for Primary Care and Public Health in Lausanne, Switzerland, explores the effectiveness of forming implementation intentions to regulate emotions, specifically disgust, through perspective taking. The study found that participants who formed a goal intention linked to a perspective taking implementation intention showed a significant decrease in disgust compared to other groups. The study highlights the importance of creating a mental link between situational cues and goal-directed responses for effective emotion regulation. This peer-reviewed research provides valuable insights into the role of implementation intentions in downregulating negative emotions like disgust. [Extracted from the article]

A recent study conducted by the University of Lausanne in Switzerland examined the lack of evidence for cultural heterogeneity in the replication of psychological effects. The research, funded by various organizations, found little cultural variability and low power to detect cultural heterogeneity effects in the Many Labs 2 data. The study suggests that future research on cultural heterogeneity should consider theoretical and methodological planning to improve the detection of effects. This peer-reviewed research provides valuable insights into the replication of psychological effects across different cultures. [Extracted from the article]

A recent systematic review conducted by Lausanne University Hospital and University of Lausanne explores the relationship between irritability and self-regulatory control processes in children and adolescents. The review, which included 82 articles from 74 studies, suggests that irritability is associated with lower effortful control, cognitive control, and delay intolerance. Additionally, the research highlights the importance of regulation skills for positive and negative emotions, as well as the influence of parenting practices on a child's irritability. This study provides valuable insights into understanding irritability in psychopathology and identifies areas for further research. [Extracted from the article]

A recent study conducted by investigators from the University of Lausanne examined the effects of birthplace altitude and training volume on hematological characteristics in young male Colombian cyclists. The research found that altitude-native athletes may have advantages in total hemoglobin mass (tHb(mass)), hematocrit percentage, and hemoglobin concentration compared to low-altitude athletes. These findings could impact talent identification and development strategies in cycling. The study was published in the International Journal of Sports Physiology and Performance and was peer-reviewed. [Extracted from the article]

Researchers at the Swiss Federal Institute of Technology Lausanne have developed a 3D printable ink made from kappa-carrageenan, a polysaccharide extracted from algae. This ink can be used to create load-bearing structures at room temperature through a process called direct ink writing. By adding metal ions and glucose, the stiffness and strength of the structures can be increased significantly. The researchers believe that this algae-derived ink could be a viable alternative to animal-based gelatin for tissue engineering and food applications. [Extracted from the article]

A recent study conducted at the University of Lausanne in Switzerland aimed to validate a French version of the City Birth Trauma Scale (partner version) (City BiTS (P)) to measure symptoms of childbirth-related posttraumatic stress disorder (CB-PTSD) in fathers. The study found that the two-factor model with birth-related symptoms (BRS) and general symptoms (GS) provided the best fit to the data, and the City BiTS-F (P) was found to be a reliable and validated tool to assess CB-PTSD symptoms in French-speaking partners. The researchers recommend using the total score in addition to the BRS and GS subscale scores. [Extracted from the article]

A recent study conducted by the Nestle Institute of Health Sciences in Lausanne, Switzerland, has found that a biological age clock based on clinical blood tests can predict the health trajectories and mortality risk in dogs. The researchers compared correlations of standard clinical blood parameters with survival probability in humans, cats, and dogs, and developed an algorithm that predicts biological age in canines. The study also showed that restricted caloric intake can lower biological age in dogs. This research has important implications for veterinary practice and further research in the field of aging. [Extracted from the article]

A recent study conducted at the University of Lausanne Hospital in Switzerland examined the grading of lung squamous cell carcinoma (LUSC) and the histomorphologic feature of tumor budding (TB). The researchers aimed to compare TB between preoperative biopsies and resection specimens and assess interobserver variability. The study found that the TB score obtained from preoperative biopsies was insufficient in establishing the final TB score of the resected tumor. The research highlights the reproducibility of TB as a factor in LUSC but also identifies areas of scoring ambiguity. [Extracted from the article]

A report from the University of Lausanne in Switzerland discusses the prevalence and assessment practices of pain, sedation, iatrogenic withdrawal syndrome, and delirium in European pediatric intensive care units (PICUs). The study found that while most PICUs assessed pain and sedation, there was variability in the assessment practices and a lack of adherence to recommendations, particularly for delirium. The research highlights the need for improved dissemination and investigation of barriers and implementation strategies to enhance evidence-based assessment practices in PICUs. [Extracted from the article]

A recent study conducted at the University of Lausanne Hospital in Switzerland examined the perception of coercion in psychiatry. The researchers compared the perceived severity of formal coercion (such as involuntary hospitalization) with four domains of severe informal coercion (finance, housing, criminal justice, and child custody) among 456 psychiatric patients. The study found that all four domains of severe informal coercion were perceived as more severe than formal coercion, with child custody being perceived as the most severe. The researchers concluded that the degree of severity of coercion may not align with the experiences of the patients. This research has been peer-reviewed and published in Psychiatry Psychology and Law. [Extracted from the article]

A recent study conducted by the Nestle Institute of Health Sciences in Lausanne, Switzerland, examined the impact of complexation or complex coacervation of lactoferrin (LF) and osteopontin (OPN) on simulated infant gastrointestinal digestion, intestinal inflammation, and in vivo bone development. The research found that LF-OPN complexation and complex coacervation can delay the digestion of LF in infants and protect or improve the bioactivity of the proteins. In preclinical models, the complexation of LF and OPN improved bone structures and increased the levels of certain proteins related to bone development. This research suggests potential benefits for infant gut and bone health. [Extracted from the article]

A recent report from Nestle Research in Lausanne, Switzerland discusses the detection of gluten peptides in human duodenal fluids using immuno-liquid chromatography-mass spectrometry. The researchers aimed to develop a mass spectrometry-based method for measuring gluten peptides in biological samples. They used isotopically labeled peptides as references and designed a targeted liquid chromatography mass spectrometry assay. The researchers concluded that their method was sensitive, quantitative, and reproducible. This research has been peer-reviewed and provides valuable insights for individuals suffering from gluten-related disorders. [Extracted from the article]

A recent study conducted at the University Hospital Lausanne in Switzerland aimed to identify and visualize patient clusters in refractory musculoskeletal pain syndromes using a variety of clinical variables. The study involved 202 patients, with 78% meeting the criteria for fibromyalgia and 77% having a concomitant psychiatric-mediated disorder. Five patient phenotypes were identified through unsupervised machine learning, and a predictive model for pain response was generated. The researchers suggest that digital personas and avatars created through this process could potentially be used in the development of personalized therapeutic modalities and clinical trials. [Extracted from the article]

New research conducted by Nestle Research in Lausanne, Switzerland explores the use of the Molecular Networking (MN) approach to identify chemicals that may migrate from packaging materials into food. The study found that the MN approach facilitated the identification of unknown chemicals, improving the safety assessment of packaging materials. This research provides valuable insights into the complexity of chemicals in food packaging and their potential impact on consumer exposure. For more information, refer to the article "Deciphering the complexity of the chemicals in food packaging materials using molecular networks" published in Food Chemistry. [Extracted from the article]

A report from University Hospital Lausanne in Switzerland discusses the treatment of peritonitis in a child on automated peritoneal dialysis. The researchers found that there is no guidance on how to administer vancomycin in children on this type of dialysis. They present a dosing strategy based on a review of the literature, highlighting the importance of a sufficient dwell period to allow for optimal distribution of vancomycin. The study concludes that this dosing strategy is critical for treating pediatric patients on automated peritoneal dialysis. [Extracted from the article]