67 results on '"Laurenzi F"'
Search Results
2. Can Ventricular Rate Stabilisation Reduce Symptoms of Atrial Fibrillation?
- Author
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Dini, P., Laurenzi, F., and Raviele, Antonio, editor
- Published
- 2002
- Full Text
- View/download PDF
3. SSS Patients: Atrial or Dual-Chamber Pacing?
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Dini, P., Adinolfi, E., Avella, A., Laurenzi, F., Pappalardo, A., and Raviele, Antonio, editor
- Published
- 2000
- Full Text
- View/download PDF
4. Experimental and computational analysis of immiscible liquid–liquid dispersions in stirred vessels
- Author
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Laurenzi, F., Coroneo, M., Montante, G., Paglianti, A., and Magelli, F.
- Published
- 2009
- Full Text
- View/download PDF
5. ACCURACY OF 3D RIGHT VENTRICLE RECONSTRUCTION PERFORMED WITH CARTOSOUND SYSTEMS IN ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY: 23.8
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Avella, A., De Girolamo, P., Pappalardo, A., Re, F., Laurenzi, F., Dottori, S., Baratta, P., dʼAmati, G., and Zachara, E.
- Published
- 2011
6. COMBINED USE OF CRYO-BALLOON AND FOCAL OPEN-IRRIGATION RADIOFREQUENCY ABLATION FOR THE TREATMENT OF PERSISTENT ATRIAL FIBRILLATION: ACUTE AND LONG TERM RESULTS: 16.8
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Pappalardo, A., Forleo, G., Avella, A., De Girolamo, P., Laurenzi, F., Ruskin, J., Tondo, C., and Mansour, M.
- Published
- 2011
7. PV ISOLATION USING A COMBINED APPROACH WITH PHASED-RF DUTY CYCLE CATHETER AND NAVX MAPPING SYSTEM: 10.4
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Laurenzi, F., De Girolamo, P., Avella, A., Pappalardo, A., Forleo, G., and Benedetti, S.
- Published
- 2011
8. DUTY-CYCLED BIPOLAR/UNIPOLAR RF ENERGY ABLATION OF THE CAVOTRICUSPID ISTHMUS: SINGLE CENTER INITIAL EXPERIENCE WITH AN INNOVATIVE HEXAPOLAR LINEAR ABLATION CATHETER: 1.2
- Author
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Avella, A., De Girolamo, P., Laurenzi, F., Pappalardo, A., and Benedetti, S.
- Published
- 2011
9. A COMBINED CRYOENERGY AND RADIOFREQUENCY APPROACH TO CATHETER ABLATION OF PERSISTENT ATRIAL FIBRILLATION: PRELIMINARY RESULTS FROM A PILOT STUDY: 10.6
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Tondo, C., Forleo, G. B., Pappalardo, A., Heist, E. K., Avella, A., Laurenzi, F., De Girolamo, P., Bencardino, G., Dello Russo, A., Casella, M., Barret, C., Ruskin, J. N., and Mansour, M.
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- 2009
10. INITIAL EXPERIENCE IN THE USE OF CARTOSOUND SYSTEM TO PERFORM 3D ANATOMY RECONSTRUCTION OF VENTRICULAR CHAMBERS: 6.2
- Author
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Avella, A., De Girolamo, P., Pappalardo, A., Laurenzi, F., Bencardino, G., Pelargonio, G., Casella, M., Visigalli, L., and Tondo, C.
- Published
- 2009
11. INITIAL EXPERIENCE IN THE USE OF CARTOSOUNDTM SYSTEM TO GUIDE RADIOFREQUENCY CATHETER ABLATION OF SEVERELY SYMPTOMATIC MONOMORPHIC VENTRICULAR PREMATURE BEATS: 6.3
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Avella, A., De Girolamo, P., Laurenzi, F., Pappalardo, A., Bencardino, G., Zecchi, P., Visigalli, L., and Tondo, C.
- Published
- 2009
12. SSS Patients: Atrial or Dual-Chamber Pacing?
- Author
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Dini, P., primary, Adinolfi, E., additional, Avella, A., additional, Laurenzi, F., additional, and Pappalardo, A., additional
- Published
- 2000
- Full Text
- View/download PDF
13. Impact of mitral regurgitation on the outcome of patients treated with CRT-D: Data from the InSync ICD Italian registry
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Giuseppe, Boriani, M. D., H. D., P, Maurizio, Gasparini, † MAURIZIO LANDOLINA, ‡ MAURIZIO LUNATI, MAURO BIFFI, Massimo, Santini, LUIGI PADELETTI, Giulio, Molon, †† GIANLUCA BOTTO, ‡‡ TIZIANA DE SANTO, B. S., and SERGIO VALSECCHI, Gasparini, M., Galimberti, P., Regoli, F., Ceriotti, C., Istituto Clinico Humanitas, Rozzano-, Milano, Lunati, M., Cattafi, G., Magenta, G., Paolucci, M., Vecchi, R., Niguarda, Hospital, Milano, Santini, M., Ricci, R., San Filippo Neri, Roma, Gaita, F., Bocchiardo, M., Didonna, P., Caponi, D., Civile, Hospital, Asti, Tavazzi, L., Landolina, M., Rordorf, R., Petracci, B., Vicentini, A., Savastano, S., Matteo, Pol. S., Pavia, Padeletti, L., Pieragnoli, P., Careggi, Firenze, Vincenti, A., Deceglia, S., Cir ` o, A., Gerardo Dei Tintori, S., Monza(MI), Curnis, A., Mascioli, G., Spedali, Civili, Brescia, Puglisi, A., Bianchi, S., Peraldo, C., Fatebenefratelli, Roma, Sassara, M., Achilli, A., Turreni, F., Rossi, P., Belcolle, Hospital, Viterbo, Perego, Gb., Luca Auxologico, S., Ravazzi, P. A., Diotallevi, P., Antonio e Biagio, Ss., Alessandria, Tritto, M., Mater, Domini, Castellanza, (VA), Carboni, A., Ardissino, D., Gonzi, G., Serra, V., Civile, Parma, Vergara, G., Maria Del Carmine, S., Rovereto, (TN), Boriani, G., Biffi, M., Martignani, C., Diemberger, I., Orsola-Mailpighi, S., Bologna, Luzzi, G., Policlinico, Bari, Laurenzi, F., Camillo, S., Pistis, G., Mauriziano, Torino, Cesario, A., Grassi, G. B., Ostia, (RM), Zanotto, G., Civile, Verona, Orazi, S., Rieti, Ometto, R., Bonanno, C., Bortolo, S., Vicenza, Molon, G., Barbieri, E., Cuore, S., Negrar, (VR), Raviele, A., Gasparini, G., Umbertoi, Mestre, (VE), Botto, G., Luzi, M., Sagone, A., Anna, S., Como, Vado, A., Croce, S., Cuneo, Montenero, A., Multimedica, Giovanni (MI), Sestos., Inama, G., Maggiore, Crema, Sassone, B., Civile, Bentivoglio, (BO), Briedda, M., Zardo, F., Maria, S., Pordenone, E. Bertaglia, Mirano (VE), Proclemer, A., Udine, Zanon, F., Civile, Rovigo, Disertori, M., Gramegna, L., Delgreco, M., Dallafior, D., Chiara, S., Trento, Tomasi, C., Maresta, A., Piancastelli, M., Maria Croci, S., Ravenna, Bridda, A., Martino, S., Belluno, Mantovan, R., C`afoncello, Treviso, Fusco, A., Pederzoli, Peschiera, (VR), Baraldi, P., Agostino, S., Modena, G. Lonardi, Legnago (VR), Rahue, W., Maurizio, S., Bolzano, P. Delise, Conegliano (TV), Menozzi, C., Marianuova, S., Reggioemilia, Babudri, P., Borgoroma, Verona, Marconi, R., Mazzoni, Ascolipiceno, Alfano, G. DeFabrizio F., Moscati, G., Avellino, Barbato, G., Maggiore, Bologna, P. Gelmini, Desenzano (BS), Disabato, Leopoldo, S., Merate, (LC), Ricci, S., Ramazzini, Carpi, (MO), Aulerio, M. D., Biagio, S., Domodossola, (VB), Morgagni, G. L., Latini, R., Macerata, Bardelli, G., Fornaroli, Magenta, (MI), R. Paulichl, F. Tappeiner Merano (BZ), Bernasconi, M., Marzegalli, M., Carlo, S., Neri, G., Montebelluna, Treviso, E. Occhetta, Novara, Bocconcelli, P., Salvatore, S., Pesaro, A. Capucci, Piacenza, Campana, A., Giovanni, S., Salerno, N. Dibelardino, Velletri (RM), Vaglio, A., Giovanni, e Paolo, Venezi, A., Boriani G, Gasparini M, Landolina M, Lunati M, Biffi M, Santini M, Padeletti L, Molon G, Botto G, de Santo T, Valsecchi S, and InSync/InSync ICD Italian Registry Investigators.
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Male ,Mitral Valve Insufficiency ,Socio-culturale ,heart failure ,Comorbidity ,CARDIAC RESYNCHRONIZATION THERAPY ,mitral regurgitation ,Risk Assessment ,Survival Analysis ,Survival Rate ,Treatment Outcome ,Italy ,Risk Factors ,Prevalence ,Humans ,Female ,Registries ,Aged - Abstract
We assessed the influence of clinically significant mitral regurgitation (MR) on clinical-echocardiographic response and outcome in heart failure (HF) patients treated with a biventricular defibrillator (cardiac resynchronization therapy defibrillator [CRT-D]). METHODS AND RESULTS: A total of 659 HF patients underwent successful implantation of CRT-D and were enrolled in a multicenter prospective registry (median follow-up of 15 months). Following baseline echocardiographic evaluation, patients were stratified into two groups according to the severity of MR: 232 patients with more than mild MR (Group MR+: grade 2, 3, and 4 MR) versus 427 patients with mild (grade 1) or no functional MR (Group MR-). On 6- and 12-month echocardiographic evaluation, MR was seen to have improved in the vast majority of MR+ patients, while it remained unchanged in most MR- patients. On 12-month follow-up evaluation, a comparable response to CRT was observed in the two groups, in terms of the extent of left ventricular reverse remodeling and combined clinical and echocardiographic response. During long-term follow-up, event-free survival did not differ between MR+ and MR- patients, even when subpopulations of patients with ischemic heart disease and with dilated cardiomyopathy were analyzed separately. On multivariate analysis, the only independent predictor of death from any cause was the lack of β-blocker use. CONCLUSIONS: This observational analysis supports the use of CRT-D in HF patients with clinically significant MR; MR had no major influence on patient outcome.
- Published
- 2012
14. Effectiveness of cardiac resynchronization therapy in heart failure patients with valvular heart disease: comparison with patients affected by ischaemic heart disease or dilated cardiomyopathy. The InSync/InSync ICD Italian Registry
- Author
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Boriani, G, Gasparini, M, Landolina, M, Lunati, M, Biffi, M, Santini, M, Padeletti, L, Molon, G, Botto, G, De Santo, T, Valsecchi, S, Galimberti, P, Regoli, F, Ceriotti, C, Cattafi, G, Magenta, G, Paolucci, M, Vecchi, R, Ricci, R, Gaita, F, Bocchiardo, M, Didonna, P, Caponi, D, Tavazzi, L, Rordorf, R, Petracci, B, Vicentini, A, Savastano, S, Matteo, Ps, Pieragnoli, P, Vincenti, A, Deceglia, S, Ciró, A, Gerardo Dei Tintori, S, Curnis, A, Mascioli, G, Puglisi, A, Bianchi, S, Peraldo, C, Sassara, M, Achilli, A, Turreni, F, Rossi, P, Perego, Gb, Ravazzi, Pa, Diotallevi, P, Antonio, e Biagio SS, Tritto, M, Carboni, A, Ardissino, D, Gonzi, G, Serra, V, Vergara, G, Maria Del Carmine, S, Martignani, C, Frabetti, L, Orsola-Mailpighi, S, Luzzi, G, Laurenzi, F, Camillo, S, Pistis, G, Cesario, A, Grassi, Gb, Zanotto, G, Orazi, S, Ometto, R, Bonanno, C, Bortolo, S, Barbieri, E, Cuore, S, Raviele, A, Gasparini, G, Luzi, M, Sagone, A, Anna, S, Vado, A, Croce, S, Montenero, A, Giovanni, Ss, Inama, G, Sassone, B, Briedda, M, Zardo, F, Maria, S, Bertaglia, E, Proclemer, A, Zanon, F, Disertori, M, Gramegna, L, Delgreco, M, Dallafior, D, Chiara, S, Tomasi, C, Maresta, A, Piancastelli, M, Maria Croci, S, Bridda, A, Martino, S, Mantovan, R, Fusco, A, Baraldi, P, Agostino, S, Lonardi, G, Rahue, W, Maurizio, S, Delise, P, Menozzi, C, Marianuova, S, Babudri, P, Marconi, R, Defabrizio, G, Alfano, F, Moscati, G, Barbato, G, Gelmini, P, Disabato, Leopoldo, S, Ricci, S, Aulerio, Md, Biagio, S, Morgagni, Gl, Latini, R, Bardelli, G, Paulichl, R, Tappeiner Merano, F, Bernasconi, M, Marzegalli, M, Carlo, S, Neri, G, Occhetta, E, Bocconcelli, P, Salvatore, S, Capucci, A, Campana, A, Giovanni, S, Dibelardino, N, Vaglio, A, Boriani G, Gasparini M, Landolina M, Lunati M, Biffi M, Santini M, Padeletti L, Molon G, Botto G, De Santo T, and Valsecchi S
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Cardiomyopathy, Dilated ,Male ,medicine.medical_specialty ,Pacemaker, Artificial ,medicine.medical_treatment ,Cardiac resynchronization therapy ,Cardiomyopathy ,Heart Valve Diseases ,Myocardial Ischemia ,Socio-culturale ,Heart failure ,Aged ,Atrial Fibrillation ,Defibrillators, Implantable ,Female ,Heart Failure ,Humans ,Middle Aged ,Registries ,Treatment Outcome ,Ventricular Remodeling ,Cardiac Pacing, Artificial ,Clinical Research ,Internal medicine ,medicine ,cardiovascular diseases ,Remodelling ,Valvular heart disease ,Heart transplantation ,Ejection fraction ,business.industry ,valvular heart disease ,Atrial fibrillation ,Dilated cardiomyopathy ,medicine.disease ,Cardiology ,cardiovascular system ,Cardiology and Cardiovascular Medicine ,business - Abstract
Aims To analyse the effectiveness of cardiac resynchronization therapy (CRT) in patients with valvular heart disease (a subset not specifically investigated in randomized controlled trials) in comparison with ischaemic heart disease or dilated cardiomyopathy patients. Methods and results Patients enrolled in a national registry were evaluated during a median follow-up of 16 months after CRT implant. Patients with valvular heart disease treated with CRT ( n = 108) in comparison with ischaemic heart disease ( n = 737) and dilated cardiomyopathy ( n = 635) patients presented: (i) a higher prevalence of chronic atrial fibrillation, with atrioventricular node ablation performed in around half of the cases; (ii) a similar clinical and echocardiographic profile at baseline; (iii) a similar improvement of LVEF and a similar reduction in ventricular volumes at 6–12 months; (iv) a favourable clinical response at 12 months with an improvement of the clinical composite score similar to that occurring in patients with dilated cardiomyopathy and more pronounced than that observed in patients with ischaemic heart disease; (v) a long-term outcome, in term of freedom from death or heart transplantation, similar to patients affected by ischaemic heart disease and basically more severe than that of patients affected by dilated cardiomyopathy. Conclusion In ‘real world’ clinical practice, CRT appears to be effective also in patients with valvular heart disease. However, in this group of patients the outcome after CRT does not precisely overlap any of the two other groups of patients, for which much more data are currently available.
- Published
- 2009
15. Heart rate variability monitored by the implanted device predicts response to CRT and long-term clinical outcome in patients with advanced heart failure
- Author
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Landolina, M, Gasparini, M, Lunati, M, Santini, M, Rodorf, R, Vincenti, A, Montenero AS, Diotallevi P., Bonanno, C, Desanto, T, Valsecchi, S, Padeletti, L, Galimberti, P, Regoli, F, Gronda, E, Cattafi, G, Magenta, G, Paolucci, M, Vecchi, R, Niguarda, Ricci, R, Gaita, F, Bocchiardo, M, Didonna, P, Caponi, D, Tavazzi, L, Rordorf, R, Petracci, B, Vicentini, A, Savastano, S, Pieragnoli, P, Deceglia, S, Cirò, A, Curnis, A, Mascioli, G, Puglisi, A, Bianchi, S, Peraldo, C, Sassara, M, Achilli, A, Turreni, F, Rossi, P, B Perego, G, A Ravazzi, P, Diotallevi, P, Carboni, A, Ardissino, D, Gonzi, G, Serra, V, Boriani, G, Biffi, M, Martignani, C, Frabetti, L, Luzzi, G, Laurenzi, F, Pistis, G, Cesario, A, Zanotto, G, Orazi, S, Ometto, R, Molon, G, Barbieri, E, Raviele, A, Gasparini, G, Botto, G, Luzi, M, Sagone, A, Vado, A, Montenero, A, Inama, G, Sassone, B, Briedda, M, Zardo, F, Bertaglia, E, Proclemer, A, Zanon, F, Disertori, M, Gramegna, L, Delgreco, M, Dallafior, D, Tomasi, C, Maresta, A, Piancastelli, M, Bridda, A, Mantovan, R, Fusco, A, Baraldi, P, Lonardi, G, Rahue, W, Delise, P, Menozzi, C, Babudri, P, Marconi, R, G De Fabrizio, Alfano, F, Barbato, G, Gelmini, P, Disabato, Ricci, S, D Aulerio, M, L Morgagni, G, Latini, R, Bardelli, G, Paulichl, R, Bernasconi, M, Marzegalli, M, Neri, G, Occhetta, E, Bocconcelli, P, Capucci, A, Campana, A, Dibelardino, N, Vaglio, A, Landolina M, Gasparini M, Lunati M, Santini M, Rordorf R, Vincenti A, Diotallevi P, Montenero AS, Bonanno C, De Santo T, Valsecchi S, Padeletti L, and InSync/InSync ICD Italian Registry Investigators [.., Boriani G,..]
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Male ,medicine.medical_specialty ,Time Factors ,Cardiac pacing ,medicine.medical_treatment ,Socio-culturale ,Heart Rate ,Internal medicine ,Heart rate variability ,Medicine ,Humans ,In patient ,Implanted device ,Aged ,Monitoring, Physiologic ,Retrospective Studies ,Heart transplantation ,Heart Failure ,Ventricular Remodeling ,business.industry ,Follow up studies ,Cardiac Pacing, Artificial ,Retrospective cohort study ,Equipment Design ,medicine.disease ,Prognosis ,Survival Rate ,Heart failure ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies - Abstract
Background: Few data exist on the long-term changes and the prognostic value of heart rate variability (HRV) assessed by implanted devices in heart failure (HF) patients treated with resynchronization therapy (CRT). Aims: To analyze the long-term changes in the standard deviation of 5-minute median atrial–atrial sensed intervals (SDANN), and assess its role in predicting CRT efficacy and major cardiovascular events. Methods and results: We included 509 consecutive patients implanted with CRT devices. At 12-month follow-up, 44 patients had died and 86 patients had at least one HF hospitalisation. A significant increase in SDANN occurred after 4 weeks of CRT (from 69±22 ms to 82±27 ms, p
- Published
- 2008
16. Follow-up of CRT-ICD: implications for the use of remote follow-up systems. Data from the InSync ICD italian Registry
- Author
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Lunati, M, Gasparini, M, Santini, M, Landolina, M, Perego, Gb, Pappone, C, Galimberti, P, Regoli, F, Gronda, E, Cattafi, G, Magenta, G, Paolucci, M, Vecchi, R, Ricci, R, Gaita, F, Bocchiardo, M, Didonna, P, Caponi, D, Tavazzi, L, Rordorf, R, Petracci, B, Vicentini, A, Deceglia, S, Cirò, A, Curnis, A, Mascioli, G, Puglisi, A, Bianchi, S, Sassara, M, Achilli, A, Turreni, F, Rossi, P, B Perego, G, A Ravazzi, P, Diotallevi, P, Tritto, M, Carboni, A, Ardissino, D, Gonzi, G, Serra, V, Vergara, G, Boriani, G, Biffi, M, Martignani, C, Frabetti, L, Orsola, S, Luzzi, G, Laurenzi, F, Pistis, G, Cesario, A, Zanotto, G, Orazi, S, Ometto, R, Bonanno, G, Molon, G, Barbieri, E, Raviele, A, Gasparini, G, Botto, G, Luzi, M, Sagone, A, Vado, A, Montenero, A, Inama, G, Sassone, B, Briedda, M, Zardo, F, Bertaglia, E, Proclemer, A, Zanon, F, Disertori, M, Gramegna, L, Delgreco, M, Dallafior, D, Tomasi, C, Maresta, A, Piancastelli, M, Bridda, A, Mantovan, R, Fusco, A, Baraldi, P, Lonardi, G, Rahue, W, Delise, P, Menozzi, C, Babudri, P, Marconi, R, De Fabrizio, F Alfano, Moscati, G, Barbato, G, Gelmini, P, Disabato, Ricci, S, D Aulerio, M, L Morgagni, G, Latini, R, Bardelli, G, Paulichl, R, Bernasconi, M, Marzegalli, M, Vicedomini, G, Augello, G, Paglino, G, Neri, G, Occhetta, E, Bocconcelli, P, Capucci, A, Campana, A, Dibelardino, N, and Vaglio, A
- Subjects
Socio-culturale - Published
- 2008
17. Rabeprazole is equivalent to omeprazole in the treatment of erosive gastro-oesophageal reflux disease. A randomised, double-blind, comparative study of rabeprazole and omeprazole 20 mg in acute treatment of reflux oesophagitis, followed by a maintenance open-label, low-dose therapy with rabeprazole
- Author
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Pace, F., Annese, V., Prada, A., Zambelli, A., Casalini, S., Nardini, P., Bianchi Porro, G., Rossi, Z., Fenderico, P., Molinari, F., Molinari, A., Poletti, M., Benedetti, A., Bolognini, L., Cercamondi, P., Piergallini, S., Pieroni, N., Ridolfi, F., Palazzi, A., Agnolucci, A., Ceccatelli, P., Laurenzi, F., Grassini, M., Iaquinto, G., D'Onofrio, V., Giardullo, N., Pasquale, L., Sedici, A., Moschetta, R., Maurogiovanni, G., Costan, F., Germana, B., Lecis, P., Negrini, F., Signorelli, S., Landi, P., Malaguti, P., Roda, E., De, E., Gandolfi, L., Torresan, F., Chilovi, F., Benvenuti, S., Grasso, T., Adamo, S., Azzurro, M., Carrara, M., Rubbiani, C., P. V., Di, Di, M., Belvedere, F., Di, A., Giglio, A., De Medici, A., Rodino, S., Sacca, N., Neri, M., Carbone, F., Laterza, F., Trimboli, V., Accattatis, G. C., Rizzuti, L. F., Sabatino, A., Lupinacci, G., Faleo, D., De Francesco, V., Lombardi, L. P, Minenna, M., Nocchiero, M. C., Tonti, P., Bocchini, R., D'Imperio, N., Giaccari, S., Tronci, S., Dall'Acqua, S., Berrini, E., Garatti, S., Putignano, R., Sferrazzo, A., Giacosa, A., Blanchi, S., Munizzi, F., Morlando, L., Bruno, G., Guardascione, F., Benedetti, E., Orzes, N., Pincione, F., Dell'Amico, I., Vannucci, P., Maurano, A., Calabrese, A., Napoli, G., Quagliariello, G., Sabarese, G., Pracanica, G., Gullotti, G., Princiotta, A., Rando, L., Anderloni, A., Pallotta, S., Fesce, E., Abbiati, D., Crippa, C., Ideo, G. M., Mannucci, P. M., Abbiati, C., De Franchis, R., Fazzini, L., Rossi, A., Bini, M., Chahin, N. J., Testoni, P. A., Fossati, D., Frego, R., Passaretti, S., Catanzano, C., Siciliano, S., Sivero, L., Cattaneo, D., Di Martino, V., Inzirillo, A., Lavelli, M., Del Genio, A., Maffettone, V., Napolitano, V., Del Piano, M., Ballare, M., Garello, E., Orsello, M., Capezzuto, E., Amuso, M., Marino, M., Reina, G., Craxi, A., Arini, A., Di Pisa, M., Peralta, S., Ficano, L., Miceli, D., Tarantello, M., Orlando, A., Perego, M., Alvisi, C., Pozzi, L., Torello Viera, F., Marchi, S., Arpe, P., Bellini, M., Costa, F., Da Massa Carrara, P., Manghetti, M., Meletis, P., Romano, A., Torelli, E., Garcea, M. R., Lombardi, M., Tristaino, B., Farroni, F., Di Cicco, M., Proietti, M., Tanzilli, A., Benedetti, G., Guido, E., Lacchin, T., Sablich, R., Vitalba, A., Casetti, T., Cantoni, F., Salzetta, A., Polimeni, F., Bortoli, A., Buono, M., Gozzini, C., Barberani, F., Boschetto, S., Giovannone, M., Casale, V., Assisi, D., Grassi, A., Lapenta, R., Stigliano, V., Fedeli, G., Pirozzi, G. A., Pippa, G., Bazuro, M. E., Romano, M., Borgheresi, P., Andriulli, A., Fiorella, S., De Rocco, R., Greco, G., Meloni, M., Fina, G., Frosini, G., Macchiarelli, R., Virgilio, C., Borina, E., Lauria, M., Cappelletti, F., Puglisi, F., Ravizza, M., Emanuelli, G., Battaglia, E., Dughera, L., Navino, M., Ferrari, A., Martinoglio, P., Turco, D., Pera, A., Daperno, M., Lombardo, L., Gusmaroli, R., Milesi, F., Zilli, M., Brosolo, P., De, G., Zoratti, L., Curzio, M., Amato, A., Bisso, G., Feliziani, M., Gianfrate, L., Natale, C., Petillo, A., Spadaccini, A., Meddi, P., Sciampa, G., and Ubalducci, G. M.
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Adult ,Male ,Gastrointestinal ,Time Factors ,Severity of Illness Index ,2-Pyridinylmethylsulfinylbenzimidazoles ,Endoscopy, Gastrointestinal ,Helicobacter Infections ,Dose-Response Relationship ,Gastro-oesophageal reflux disease ,Double-Blind Method ,Heartburn ,Esophagitis ,Humans ,Esophagitis, Peptic ,Curative/maintenance therapy ,Peptic ,Hepatology ,Dose-Response Relationship, Drug ,Helicobacter pylori ,Rabeprazole ,Antacids ,Anti-Ulcer Agents ,Benzimidazoles ,Female ,Gastroesophageal Reflux ,Middle Aged ,Omeprazole ,Patient Satisfaction ,Treatment Outcome ,Gastroenterology ,Endoscopy ,Drug - Abstract
Previous studies have shown similar effects of rabeprazole and omeprazole, when used at the same dose in the treatment of reflux oesophagitis. However, such studies have been conducted as superiority studies but interpreted as equivalence ones.To properly assess the comparative efficacy of rabeprazole and omeprazole in inducing complete endoscopic healing and symptom relief in patients with reflux oesophagitis.Patients (n=560) with Savary-Miller grade I-III reflux oesophagitis were randomised in a double-blind, double-dummy fashion to rabeprazole or omeprazole 20 mg once daily for 4-8 weeks. Then, patients endoscopically healed and symptomatically relieved were openly maintained with rabeprazole 10 mg or 2x10 mg once daily (in the event of clinical and/or endoscopic relapse) for a maximum of 48 weeks.After 4-8 weeks of treatment, healing (primary end-point) was observed in 228/233 (97.9%) patients in the rabeprazole group and in 231/237 (97.5%) in the omeprazole one (equivalence effect demonstrated by p0.0001 at Blackwelder test and an upper confidence limit at 97.5% of 0.023). However, rabeprazole was faster in inducing heartburn relief than omeprazole (2.8+/-0.2 versus 4.7+/-0.5 days of therapy to reach the first day with satisfactory heartburn relief, p=0.0045 at log-rank test). In the maintenance phase, 15.2% of patients had an endoscopic and/or clinical relapse.Rabeprazole is equivalent to omeprazole in healing reflux oesophagitis, but shows a faster activity on reflux symptoms in the early treatment phase.
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- 2005
18. Full-haplotype mismatched hematopoietic stem cell transplantation in patients with high risk hematological malignancies
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Dentamaro, T, Cudillo, L, Rainaldi, A, Picardi, A, Postorino, M, De Laurenzi, F, Maurillo, L, Buccisano, F, Adorno, G, Ballatore, G, Mariani, M, Sconocchia, G, and Amadori, S
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- 2000
19. Poster Session 1: Ablation of atrial fibrillation
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Marti Almor, J., primary, Bazan, V., additional, Matiello, M., additional, Cian, D., additional, Oliva, X., additional, Altaba, C., additional, Guijo, M. A., additional, Bruguera, J., additional, Fiala, M., additional, Sknouril, M., additional, Dorda, M., additional, Chovancik, J., additional, Nevralova, R., additional, Jiravsky, O., additional, Jiravska-Godula, B., additional, Branny, M., additional, Elvan, A., additional, Beukema, W. P., additional, Smit, J. J. J., additional, Delnoy, P. P. H. M., additional, Ramdat Misier, A. R., additional, Tuan, J., additional, Chung, I., additional, Jeilan, M., additional, Kundu, S., additional, Osman, F., additional, Stafford, P., additional, Ng, G. A., additional, Vergara, P., additional, Mazzone, P., additional, Paglino, G., additional, Saviano, M., additional, Crisa, S., additional, Maida, G., additional, Vicedomini, G., additional, Pappone, C., additional, Miyazaki, S., additional, Wright, M., additional, Hocini, M., additional, Jais, P., additional, Haissaguerre, M., additional, Yoshitani, K., additional, Kaitani, K., additional, Hanazawa, K., additional, Nakagawa, Y., additional, Yokokawa, M., additional, Tada, H., additional, Naito, S., additional, Oshima, S., additional, Taniguchi, K., additional, Romanov, A., additional, Pokushalov, E., additional, Shugaev, P., additional, Artemenko, S., additional, Turov, A., additional, Gindele, F. M., additional, Wiedemann, M., additional, Ewertsen, C., additional, Heiderfazel, S., additional, Andresen, D., additional, Miyake, M., additional, Motooka, M., additional, Izumi, T., additional, Izumi, C., additional, Sunthorn, H., additional, Burri, H. B., additional, Gentil, P. G., additional, Shah, D. S., additional, Sugiura, S., additional, Fujii, E., additional, Senga, M., additional, Yamazato, S., additional, Nakamura, M., additional, Ito, M., additional, Den Uijl, D. W., additional, Delgado, V., additional, Tops, L. F., additional, Trines, S. A. I. P., additional, Zeppenfeld, K., additional, Van Der Wall, E. E., additional, Schalij, M. J., additional, Bax, J. J., additional, Pappalardo, A., additional, Forleo, G. B., additional, Avella, A., additional, Bencardino, G., additional, De Girolamo, P. G., additional, Dello Russo, A., additional, Laurenzi, F., additional, Tondo, C., additional, Mueller, H., additional, Burri, H., additional, Gentil-Baron, P., additional, Lerch, R., additional, Shah, D., additional, Shirokova, N., additional, Pedrote Martinez, A. A., additional, Arana, E., additional, Garcia-Riesco, L., additional, Urbano-Moral, J. A., additional, Frutos-Lopez, M., additional, Sanchez-Brotons, J. A., additional, Torres-Llergo, J., additional, Martinez-Martinez, A., additional, Matsuda, H., additional, Harada, T., additional, Nakano, E., additional, Takai, M., additional, Fujita, S., additional, Sasaki, T., additional, Mizuno, K., additional, Miyake, F., additional, Doshi, A., additional, Hummel, J., additional, Daoud, E., additional, Augostini, R., additional, Weiss, R., additional, Hart, D., additional, Houmsse, M., additional, Kalbfleisch, S., additional, Gorzolka, J., additional, Bulkova, V., additional, Wojnarova, D., additional, Neuwirth, R., additional, Januska, J., additional, Cerrato, E., additional, Amellone, C., additional, Tizzani, E., additional, Antolini, M., additional, Massa, R., additional, Golzio, P. G., additional, Comoglio, C., additional, Rinaldi, M., additional, El-Domiaty, H. A., additional, Kamal, H. M., additional, Moubarak, A. M., additional, Mansy, M. M., additional, El-Kerdawy, H., additional, Ahmed, S., additional, Klinkenberg, T. J., additional, Ten Hagen, A., additional, Wiesfeld, A. C. P., additional, Tan, E. S., additional, and Van Gelder, I. C., additional
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- 2009
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20. Electroanatomic Voltage Mapping in Arrhythmogenic Right Ventricular Cardiomyopathy
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AVELLA, A, primary, ZACHARA, E, additional, LAURENZI, F, additional, PAPPALARDO, A, additional, DIRENZI, P, additional, RE, F, additional, ALBI, F, additional, MESSINA, G, additional, and TONDO, C, additional
- Published
- 2005
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21. 78 Cardiac resynchronization therapy in NYHA II patients: the Insync/Insync ICD Italian registries
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Bocchiardo, M., primary, Gasparini, M., additional, Lunati, M., additional, Vergara, G., additional, Pistis, G., additional, Laurenzi, F., additional, Ravazzi, A., additional, and Indino, B., additional
- Published
- 2005
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22. 539 Selection of candidates for cardiac resynchronization therapy (SCART): study design and preliminary results
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PERALDO, C, primary, PUGLISI, A, additional, SASSARA, M, additional, GIARRATANA, G, additional, CESARIO, A, additional, LAURENZI, F, additional, DISEGNI, M, additional, APICELLA, G, additional, and DENARO, A, additional
- Published
- 2003
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23. A39-3 Selection of candidates for cardiac resynchronization therapy (SCART): Study design and preliminary results
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Puglisi, A., primary, Peraldo, C., additional, Sassara, M., additional, Achilli, A., additional, Lombardo, E., additional, Giarratana, G., additional, Cesario, A., additional, Laurenzi, F., additional, Apicella, G., additional, and Denaro, A., additional
- Published
- 2003
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24. 19.3 Etiologic definition of syncope in hypertrophic cardiomyopathy (HCM): The role of loop-recorder
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Avella, A., primary, Laurenzi, F., additional, Zachara, E., additional, Pappalardo, A., additional, Re, F., additional, Adinolfi, E., additional, Messina, G., additional, and Vajola, S.F., additional
- Published
- 2003
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25. Influence of myocardial viability on responsiveness to cardiac resynchronization in ischemic dilated cardiomyopathy: a prospective observational cohort study.
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Pugliese M, Minardi G, Vitali A, Natale E, De Girolamo P, Zampi G, Leggio M, Chiarelli A, Pappalardo A, Avella A, Laurenzi F, and Fera MS
- Abstract
OBJECTIVE: To understand whether patients with post-ischemic dilated cardiomyopathy and myocardial viability (MV) could benefit from cardiac resynchronization therapy (CRT) in terms of clinical, echocardiographic and neuro- hormonal parameters compared to patients without MV. METHODS: One hundred and four consecutive patients were enrolled in a prospective observational cohort study. Using dobutamine stress echocardiography, 2 groups were identified: group A of 51 patients with MV and group B of 53 patients without MV. All patients were implanted with biventricular pacing devices combined with an internal cardioverter-defibrillator. Clinical, echocardiographic and neuro-hormonal parameters were evaluated at baseline and at six month follow-up. Analysis of variance for repeated measures on each variable suggestive of remodeling was performed. We considered responder every patient with: decrease of > 15% in left ventricular volumes and/or improvement in left ventricular ejection fraction of > 5% in addition to NYHA class improvement. RESULTS: All the variables improved in both groups (time effect). Comparing the two groups (group effect), the following variables were significantly better in group A: N-terminal pro-B-type natriuretic peptide (p=0.02), NYHA class (p=0.003), reverse remodeling (RR) (p=0.007), dP/dt (p=0.005), left ventricular ejection fraction (p=0.009), 3rd sound (p=0.01), and left ventricular end-systolic volume after the first week (p=0.035). RR occurred at the first week after CRT only in Group A and was maintained for all the time of this study. The maximum difference of the decrease of left ventricular volumes between the two groups occurred after the first week (p<0.001). CONCLUSION: Patients with MV responded better than patients without MV with a significant improvement after the first week from CRT. [ABSTRACT FROM AUTHOR]
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- 2012
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26. Biventricular upgrading in patients with conventional pacing system and congestive heart failure: results and response predictors.
- Author
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Laurenzi F, Achilli A, Avella A, Peraldo C, Orazi S, Perego GB, Cesario A, Valsecchi S, DE Santo T, Puglisi A, and Tondo C
- Abstract
Background: There are few studies on cardiac resynchronization therapy (CRT) in heart failure (HF) patients with preexisting right ventricular (RV) pacing. The purpose of this study was to determine the efficacy of CRT upgrading in RV-paced patients and the predictivity of electromechanical dyssynchrony parameters (EDP) evaluated by standard echocardiography (ECHO) and tissue Doppler imaging (TDI). Methods: Thirty-eight consecutive patients with HF [New York Heart Association (NYHA) class III or IV, LVEF < 35%], prior continuous RV pacing, and absence of atrial fibrillation were enrolled in the presence of a paced QRS >/= 150 ms and evaluated by ECHO and TDI. A responder was defined as a patient with a favorable change in NYHA class and neither HF hospitalization nor death, plus an absolute increase of LVEF >/= 10 units. Results: At six-months follow-up, the whole study population had significant improvement in symptoms, systolic function, and QRS duration (P < 0.001); 32 (84%) patients had a favorable clinical outcome, 25 (66%) were considered responders according to the previous definition. Postimplant QRS was similarly reduced in both responders and nonresponders, whereas EDP had a significant improvement only in responders (P < 0.05). Using EDP, 23 (79%) patients were responders compared with 2 (22%) patients without mechanical dyssynchrony (P = 0.002). Conclusions: In HF patients with previous RV pacing, CRT is effective to improve clinical, functional outcome, and LV performance and to reduce electromechanical dyssynchrony in a large proportion of patients. Dyssynchrony evaluated by standard and TDI ECHO can be useful for CRT selection of paced patients. [ABSTRACT FROM AUTHOR]
- Published
- 2007
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27. A comparison of the assessment of mitral valve area by continuous wave Doppler and by cross sectional echocardiography.
- Author
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Loperfido, F, Laurenzi, F, Gimigliano, F, Pennestri, F, Biasucci, L M, Vigna, C, De Santis, F, Favuzzi, A, Rossi, E, and Manzoli, U
- Abstract
Transmitral pressure half time (PHT) was assessed by continuous wave Doppler in 44 patients with rheumatic mitral valve stenosis (14, pure mitral valve stenosis; 15, combined mitral stenosis and regurgitation; and 15 with associated aortic valve regurgitation). The mitral valve area, derived from transmitral pressure half time by the formula 220/pressure half time, was compared with that estimated by cross sectional echocardiography. The transmitral pressure half time correlated well with the mitral valve area estimated by cross sectional echocardiography. The correlation between pressure half time and the cross sectional echocardiographic mitral valve area was also good for patients with pure mitral stenosis and for those with associated mitral or aortic regurgitation. The regression coefficients in the three groups of patients were significantly different. Nevertheless, a transmitral pressure half time of 175 ms correctly identified 20 of 21 patients with cross sectional echocardiographic mitral valve areas less than 1.5 cm2. There were no false positives. The Doppler formula significantly underestimated the mitral valve area determined by cross sectional echocardiography by 28(9)% in 19 patients with an echocardiographic area greater than 2 cm2 and by 14.8 (8)% in 25 patients with area of less than 2 cm2. In thirteen patients with pure mitral valve stenosis Gorlin's formula was used to calculate the mitral valve area. This was overestimated by cross sectional echocardiography by 0.16 (0.19) cm2 and underestimated by Doppler by 0.13 (0.12) cm2. Continuous wave Doppler underestimated the echocardiographic mitral valve area in patients with mild mitral stenosis. The Doppler formula mitral valve area = 220/pressure half time was more accurate in predicting functional (haemodynamic) than anatomical (echocardiographic) mitral valve area. [ABSTRACT FROM PUBLISHER]
- Published
- 1987
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28. Full-haplotype mismatched hematopoietic stem cell transplantation in patients with high risk hematological malignancies
- Author
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Dentamaro, T., Cudillo, L., Rainaldl, A., Picardi, A., massimiliano postorino, and Laurenzi, F.
29. A comparison of the assessment of mitral valve area by continuous wave Doppler and by cross sectional echocardiography.
- Author
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Loperfido, F, primary, Laurenzi, F, additional, Gimigliano, F, additional, Pennestri, F, additional, Biasucci, L M, additional, Vigna, C, additional, De Santis, F, additional, Favuzzi, A, additional, Rossi, E, additional, and Manzoli, U, additional
- Published
- 1987
- Full Text
- View/download PDF
30. Prediction of response to cardiac resynchronization therapy: the selection of candidates for CRT (SCART) study.
- Author
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Achilli A, Peraldo C, Sassara M, Orazi S, Bianchi S, Laurenzi F, Donati R, Perego GB, Spampinato A, Valsecchi S, Denaro A, Puglisi A, and SCART Study Investigators
- Abstract
Background: The aim of this study was to evaluate the ability of baseline clinical and echocardiographic parameters to predict a positive response to CRT. Methods: We analyzed 6-month data from the first 133 consecutive patients enrolled in a multicenter prospective study. These patients had symptomatic heart failure (HF) refractory to pharmacological therapy (NYHA class II-IV), left ventricular ejection fraction (LVEF) <=35%, and prespecified electrocardiographic, echocardiographic or tissue Doppler imaging markers of left ventricular (LV) dyssynchrony. Results: After a follow-up period of 6 months, 1 patient died and 13 were hospitalized for worsening HF. There were significant (P < 0.01) clinical, functional, and echocardiographic improvements that included: New York heart Association Class, Quality-of-Life Score, QRS duration, LVEF, LV end-diastolic and end-systolic diameter (LVESD), and severity of mitral regurgitation A positive response was documented in 90/133 (68%) patients who presented an improved clinical composite score associated to an increase in LVEF >= 5 units. A multivariate analysis identified that a smaller LVESD (OR = 0.957, 95% CI 0.920-0.996; P = 0.030) and longer interventricular mechanical delay (IVMD) (OR = 1.017, 95% CI 1.005-1.029, P = 0.007) as independent predictors of a positive response. Receiver-operating curve analysis showed that a positive response to CRT may be predicted in patients with IVMD > 44 ms (with a sensitivity of 66% and a specificity of 55%) or with LVESD < 60 mm (with a sensitivity of 66% and a specificity of 61%). Conclusions: Our results confirm the limited value of QRS duration in the selection of patients for CRT. A less-advanced stage of disease and echocardiographic evidence of interventricular dyssynchrony demonstrated to predict response to CRT, while intraventricular dyssynchrony did not predict response. [ABSTRACT FROM AUTHOR]
- Published
- 2006
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31. 13. Brugada Syndrome, LQTS, and ARVC.
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Avella, A., Zachara, E., Laurenzi, F., Pappalardo, A., Di Renzi, P., Re, F., Albi, F., Messina, G., and Tondo, C.
- Abstract
Background Electroanatomic (EA) voltage mapping of the right ventricle (RV) by CARTO System has recently been proposed as a new diagnostic tool to identify dysplastic regions in patients affected with arrhythmogenic right ventricular cardiomyopathy (ARVC). Three-dimensional reconstruction of endocavitary electrogram distribution, performed by CARTO System, would allow the identification of RV low voltage areas, reflecting fibrofatty myocardial replacement. The purpose of our study was to compare EA voltage mapping during sinus rhythm with RV non-invasive assessment in ARVC patients. Methods we enrolled ten consecutive patients fulfilling standardized diagnostic criteria for ARVC (age range: 28-46 years, 5 males), with indication to electrophysiological test to evaluate ventricular electrical vulnerability or to validate an empirically selected antiarrhythmic treatment. After an integrated ECHO + MRI evaluation, an invasive EA reconstruction of RV was performed sampling multiple endocardial sites (202 ± 61) during sinus rhythm. Voltage map analysis was performed with a 0.5-1.5 mV colour range setting of voltage display. Results in all patients voltage mapping documented very low voltage areas (= 0.5 mV) consisting with transmural fibrofatty replacement. Voltage analysis demonstrated in all patients different degrees of involvement of RV segments and a marked dispersion of amplitude and duration values (unipolar and bipolar). Analysis of EA distribution of low voltage areas documented a greater involvement of outflow and inflow tracts compared with RV apex and evidenced a lesser involvement of septal wall compared with free wall. In all patients concordance was noted between EA mapping results and non-invasive morphological-functional RV evaluation. Conclusions voltage mapping appears to be a promising method to study ARVC. [ABSTRACT FROM PUBLISHER]
- Published
- 2005
32. A39-3 Selection of candidates for cardiac resynchronization therapy (SCART): Study design and preliminary results.
- Author
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Puglisi, A., Peraldo, C., Sassara, M., Achilli, A., Lombardo, E., Giarratana, G., Cesario, A., Laurenzi, F., Apicella, G., and Denaro, A.
- Published
- 2002
33. 19.3 Etiologic definition of syncope in hypertrophic cardiomyopathy (HCM): The role of loop-recorder.
- Author
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Avella, A., Laurenzi, F., Zachara, E., Pappalardo, A., Re, F., Adinolfi, E., Messina, G., and Vajola, S.F.
- Published
- 2002
34. STUDIO MONOCENTRICO RANDOMIZZATO SULLA PERFUSIONE IPOTERMICA OSSIGENATA VS. CONSERVAZIONE STATICA NEL TRAPIANTO DI FEGATO CON DONATORI CON CRITERI ESTESI: ANALISI AD INTERIM PRELIMINARE
- Author
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M. Ravaioli, G. Germinario, L. Maroni, F. Odaldi, G. Frascaroli, C. Zanfi, V. R. Bertuzzo, M. Del Gaudio, M. Serenari, A. Laurenzi, F. Vasuri, G. Sangiorgi, A. D'Errico, M. C. Morelli, M. Cescon, and M. Ravaioli, G. Germinario, L. Maroni, F. Odaldi, G. Frascaroli, C. Zanfi, V.R. Bertuzzo, M. Del Gaudio, M. Serenari, A. Laurenzi, F. Vasuri, G. Sangiorgi, A. D'Errico, M.C. Morelli, M. Cescon
- Subjects
PERFUSIONE IPOTERMICA OSSIGENATA DONATORI CON CRITERI ESTESI - Published
- 2021
35. Comparison of the Effects of Cardiac Resynchronization Therapy in Patients With Class II Versus Class III and IV Heart Failure (from the InSync/InSync ICD Italian Registry)
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Landolina M, Lunati M, Gasparini M, Santini M, Padeletti L, Achilli A, Bianchi S, Laurenzi F, Curnis A, Vincenti A, Valsecchi S, Denaro A, and InSync/InSync ICD Italian Registry Investigators
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- 2007
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36. A study on some effects of a drag-reducing agent on the performance of a stirred vessel
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Alessandro Paglianti, Franco Magelli, Giuseppina Maria Rosa Montante, Fabio Laurenzi, Montante G., Laurenzi F., Paglianti A., and Magelli F.
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VELOCITY FLUCTUATIONS ,Drag reducing agent ,MIXING ,General Chemical Engineering ,Barium chloride ,Mixing (process engineering) ,Analytical chemistry ,General Chemistry ,Mechanics ,MIXING PROGRESS ,PRECIPITATION REACTION ,DRUG REDUCTION ,Rushton turbine ,Impeller ,chemistry.chemical_compound ,chemistry ,Turbulence kinetic energy ,Particle-size distribution ,Mean flow - Abstract
The influence of the addition of a drag reducing agent (100 ppm PAA) to a pure liquid (water) in a stirred vessel has been studied. The vessel was stirred with two types of agitators, a Rushton turbine and an axial A310 impeller. This study was meant to implement previous findings with new data and various types of measurements were performed to determine a number of parameters. It is confirmed that the drag-reducing agent decreases power draw and increases mixing time. Mean flow and the fluctuating velocities were determined (with the PIV technique) and notable reduction in turbulence intensity was detected. The mechanism of tracer dispersion (followed by the PLIF technique) was also documented qualitatively. Finally, the influence of the drag-reducing agent on the particle size distribution of the solid product of a precipitation reaction (reaction of barium chloride and sodium sulphate) was shown.
- Published
- 2011
37. Two-phase flow and bubble size distribution in air-sparged and surface-aerated vessels stirred by a dual impeller
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Alessandro Paglianti, Giuseppina Maria Rosa Montante, Franco Magelli, Fabio Laurenzi, Montante G., Laurenzi F., Paglianti A., and Magelli F.
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Work (thermodynamics) ,Materials science ,SELF-INDUCING ,Turbulence ,General Chemical Engineering ,Bubble ,Computer Science::Neural and Evolutionary Computation ,General Chemistry ,Mechanics ,Turbine ,Industrial and Manufacturing Engineering ,BSD ,Physics::Fluid Dynamics ,PIV ,Impeller ,Computer Science::Systems and Control ,Computer Science::Computational Engineering, Finance, and Science ,GAS-LIQUID ,STIRRED TANK ,Two-phase flow ,Aeration - Abstract
The aim of this work is to investigate the turbulent hydrodynamic features of a fully baffled gas-liquid stirred vessel equipped with a dual turbine consisting of a radial concave-blade turbine and a downflow pitched blade turbine (PBT). Two different operating modes are analyzed, namely air sparged and surface aerated. A two-phase particle image velocimetry (PIV) technique, based on a single laser sheet source and two cameras, each provided with a filter for separately catching the light scattered by the liquid seeding particles or the bubbles, was adopted for detecting independently and simultaneously the liquid and bubble phase velocities. The mean flow fields of the gas and liquid phases, the rms velocity fluctuation maps of the two phases, and a comparison with the corresponding velocity measurements effected in single-phase conditions are presented. The typical bubble size distribution (BSD) in the two gas-liquid systems obtained by a digital image processing method is also presented, and its dependency on the gas feeding configuration and on the dimensionless Weber number is shown. The effects on the hydrodynamic behavior of the gas-liquid dispersion of liquid viscosity as well as of gas flow rate or impeller speed for the air-sparged and surface-aerated systems, respectively, are discussed. The results suggest that simultaneous detection of the flow fields of the two phases is required for appropriate, detailed evaluation of the system features. Even a limited viscosity change has a significant impact on the system hydrodynamics, since it affects both the flow field and the BSD.
- Published
- 2010
38. Paroxysmal and persistent atrial fibrillation ablation outcomes with the pulmonary vein ablation catheter GOLD duty-cycled phased radiofrequency ablation catheter: quality of life and 12-month efficacy results from the GOLD Atrial Fibrillation Registry.
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Boersma L, Koźluk E, Maglia G, de Sousa J, Grebe O, Eckardt L, Hokanson RB, Hemingway LA, Ostern E, Park HS, Rovaris G, Arribas F, Scharf C, Csanádi Z, Arenal Á, Laurenzi F, Klaver M, and Goette A
- Subjects
- Catheters, Female, Humans, Male, Middle Aged, Prospective Studies, Quality of Life, Recurrence, Registries, Treatment Outcome, Atrial Fibrillation diagnosis, Atrial Fibrillation surgery, Catheter Ablation adverse effects, Pulmonary Veins surgery
- Abstract
Aims: The GOLD AF Registry has been designed to prospectively assess the population, indications, and outcomes using second-generation phased radiofrequency (RF) ablation (pulmonary vein ablation catheter GOLD) in a global examination of standard-of-care use for the treatment of paroxysmal and persistent atrial fibrillation (AF)., Methods and Results: GOLD AF (NCT02433613) is a prospective, observational, multi-centre registry designed to characterize efficacy and safety of phased RF ablation in patients with AF. The primary endpoint was freedom from AF recurrence at 12-month follow-up after a 90-day blanking period. Ancillary objectives include safety, procedural efficiency, and quality of life (QoL). The QoL assessment using the Atrial Fibrillation Effect on QualiTy-of-Life (AFEQT) and the European Heart Rhythm Association (EHRA) Score of AF-related symptoms was collected at baseline and 12 months. In total, 1054 patients were included in this analysis (age 60.6, 67.6% male, 26.5% PersAF). Kaplan-Meier estimate of freedom from AF recurrence was 77.7% at 12 months. Peri-procedural device or procedure-related complications were observed in 26 (2.5%) patients, with a low stroke rate of 0.3%. One-year post-ablation, the EHRA AF Symptom score decreased in 68% of patients. The AFEQT score improvement was observed in 88.4% and 90.4% of patients who completed the questionnaire in-person or interviewed by phone at 12 month follow-up, respectively., Conclusion: Phased RF ablation for the treatment of paroxysmal and persistent AF demonstrated a 77.7% freedom from AF recurrence at 12 months in addition to a significant reduction in arrhythmia symptoms and clinically meaningful improved QoL. Low peri-procedural complication rate of <3% was reported., (© The Author(s) 2020. Published by Oxford University Press on behalf of the European Society of Cardiology.)
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- 2020
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39. Clinical outcomes of AF patients treated with the first and second-generation of circular mapping and ablation catheter: insights from a real world multicenter experience.
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Rovaris G, De Filippo P, Laurenzi F, Zanotto G, Bottoni N, Pozzi M, Giofrè F, De Girolamo P, Visentin E, Piazzi E, and Ferrari P
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- Aged, Atrial Fibrillation mortality, Cardiac Catheters, Catheter Ablation mortality, Cohort Studies, Equipment Design, Equipment Safety, Female, Fluoroscopy methods, Follow-Up Studies, Humans, Male, Middle Aged, Operative Time, Pulmonary Veins diagnostic imaging, Recurrence, Retrospective Studies, Risk Assessment, Severity of Illness Index, Survival Rate, Time Factors, Treatment Outcome, Atrial Fibrillation diagnostic imaging, Atrial Fibrillation surgery, Body Surface Potential Mapping instrumentation, Catheter Ablation methods, Pulmonary Veins surgery
- Abstract
Purpose: Complete pulmonary vein isolation (PVI) is the best documented target for catheter ablation, and different technologies have shown comparable outcomes. The multielectrode phased-RF/duty cycled (PhRF/DC) pulmonary vein ablation catheter (PVAC) and its second generation (PVAC-GOLD) have shown promising clinical results in single and multicenter experiences. Our aim is to assess and compare the safety and efficacy in the real clinical practice among two generations of circular PhRF/DC catheters by performing PVI in patients suffering from recurrent atrial fibrillation (AF)., Methods: Eighty-four AF patients treated with PVAC and 64 with PVAC-GOLD were prospectively followed in five Italian cardiology centers in the mainframe of the 1STOP-ClinicalService project., Results: Fluoroscopic and total procedure time were significantly different in the two groups. In particular, in the PVAC-GOLD group, the mean fluoroscopic time was 22.8 ± 12.7 min vs 31.6 ± 18.9 in the PVAC group (p = 0.002), and the mean total procedure duration was 117.6 ± 36.0 vs 147.4 ± 40.6, in the PVAC-GOLD group and the PVAC group, respectively (p = 0.001). Only two out of 148 patients reported a peri-procedural complication. Over 20.9 ± 12.0 months of follow-up, AF recurrence occurred in 58 patients. Kaplan-Meier freedom from AF recurrence did not differ between the two groups (64.1 ± 10% in the PVAC group vs 68.2 ± 9% in the PVAC-GOLD group at 1 year, p = ns)., Conclusions: In our multicenter analysis, AF ablation using two generations of circular PhRF/DC catheters is safe and effective. No difference was observed in terms of safety and efficacy of the AF ablation between the two catheters, with the mean procedural time being shorter in the PVAC-GOLD group.
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- 2017
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40. Isolated subtricuspid low-voltage segment in arrhythmogenic right ventricular cardiomyopathy: structural characterization by intracardiac echocardiography.
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Avella A, Re F, Pino PG, Girolamo PD, Laurenzi F, Pappalardo A, and Zachara E
- Subjects
- Action Potentials, Adipose Tissue diagnostic imaging, Adipose Tissue pathology, Adult, Arrhythmogenic Right Ventricular Dysplasia pathology, Arrhythmogenic Right Ventricular Dysplasia physiopathology, Female, Heart Ventricles pathology, Heart Ventricles physiopathology, Humans, Predictive Value of Tests, Voltage-Sensitive Dye Imaging, Arrhythmogenic Right Ventricular Dysplasia diagnostic imaging, Echocardiography, Heart Ventricles diagnostic imaging
- Published
- 2012
- Full Text
- View/download PDF
41. Catheter ablation of atrial fibrillation in patients with diabetes mellitus type 2: results from a randomized study comparing pulmonary vein isolation versus antiarrhythmic drug therapy.
- Author
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Forleo GB, Mantica M, De Luca L, Leo R, Santini L, Panigada S, De Sanctis V, Pappalardo A, Laurenzi F, Avella A, Casella M, Dello Russo A, Romeo F, Pelargonio G, and Tondo C
- Subjects
- Female, Humans, Italy, Male, Middle Aged, Treatment Outcome, Anti-Arrhythmia Agents therapeutic use, Atrial Fibrillation complications, Atrial Fibrillation therapy, Catheter Ablation methods, Diabetes Mellitus, Type 2 complications, Diabetes Mellitus, Type 2 therapy, Heart Conduction System surgery, Pulmonary Veins surgery
- Abstract
Introduction: Atrial fibrillation (AF) and diabetes mellitus type 2 (DM2) often coexist; however, a small number of patients with DM2 undergoing catheter ablation (CA) of AF have been included in previous studies. The aim of this study was to evaluate safety and efficacy of ablation therapy in DM2 patients with drug refractory AF., Methods and Results: From January 2005 to September 2006, 70 patients with a diagnosis of DM2 and paroxysmal (n = 29) or persistent (n = 41) AF were randomized to receive either pulmonary vein isolation or a new antiarrhythmic drug treatment (ADT) with a 1-year follow-up. The primary endpoint was the time to first AF recurrence. By Kaplan-Meier analysis, at the end of follow-up, 42.9% of patients in the ADT group and 80% of patients who received a single ablation procedure and were without medications were free of AF (P = 0.001). In the ablation group, a significant improvement in quality-of-life (QoL) scores as compared with ADT group was observed. Six patients in the ADT group (17.1%) developed significant adverse drug effects. Hospitalization rate during follow-up was higher in the ADT group (P = 0.01). The only complication attributable to ablation was one significant access-site hematoma., Conclusion: In patients with DM2, CA of AF provides significant clinical benefits over the ADT and appears to be a reasonable approach regarding feasibility, effectiveness, and low procedural risk.
- Published
- 2009
- Full Text
- View/download PDF
42. Diagnostic value of endomyocardial biopsy guided by electroanatomic voltage mapping in arrhythmogenic right ventricular cardiomyopathy/dysplasia.
- Author
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Avella A, d'Amati G, Pappalardo A, Re F, Silenzi PF, Laurenzi F, DE Girolamo P, Pelargonio G, Dello Russo A, Baratta P, Messina G, Zecchi P, Zachara E, and Tondo C
- Subjects
- Adult, Female, Humans, Male, Reproducibility of Results, Sensitivity and Specificity, Surgery, Computer-Assisted methods, Arrhythmogenic Right Ventricular Dysplasia diagnosis, Biopsy, Needle methods, Body Surface Potential Mapping methods
- Abstract
Unlabelled: Voltage Mapping-Guided Biopsy in ARVC/D., Introduction: To improve the endomyocardial biopsy (EMB) diagnostic sensitivity for arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D), we hypothesized a biopsy sampling focused on selected right ventricle (RV) low-voltage areas identified by electroanatomic voltage mapping., Methods and Results: The study population (22 patients, 10 men; mean age 34 +/- 10 years) included 11 patients with overt ARVC/D (group A) and 11 patients with suspected ARVC/D (group B), according to both arrhythmic profile and standardized noninvasive diagnostic criteria. In all 22 patients, an RV bipolar voltage mapping was performed with CARTO system sampling multiple endocardial sites (262 +/- 61), during sinus rhythm, with a 0.5-1.5 mV color range setting of voltage display. All 11 (100%) group A patients and 8 of the 11 (73%) group B patients (P = nonsignificant [NS]) presented RV low-voltage areas (<0.5 mV). In 8 group A patients and in all 8 group B patients with a pathological RV voltage map, an EMB focused on the low-voltage areas was performed. In 6 (75%) group A patients and in 7 (87%) group B patients (P = NS), voltage mapping-guided EMB was diagnostic for ARVC/D. In the remaining 3 patients, only nonspecific histological findings were observed., Conclusions: The results of our study (1) confirm the high diagnostic sensitivity of RV voltage mapping in patients with overt ARVC/D, (2) document a high prevalence of RV low-voltage areas even in patients with suspected ARVC/D, and (3) demonstrate that in patients with clinical evidence or suspicion for ARVC/D, presenting RV low-voltage areas, EMB guided by voltage mapping may provide ARVC/D diagnosis confirmation.
- Published
- 2008
- Full Text
- View/download PDF
43. Initial experience with the Mesh catheter for pulmonary vein isolation in patients with paroxysmal atrial fibrillation.
- Author
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Mansour M, Forleo GB, Pappalardo A, Heist EK, Avella A, Laurenzi F, De Girolamo P, Bencardino G, Dello Russo A, Mantica M, Ruskin JN, and Tondo C
- Subjects
- Aged, Feasibility Studies, Female, Humans, Male, Treatment Outcome, Atrial Fibrillation surgery, Catheter Ablation instrumentation, Heart Conduction System surgery, Pulmonary Veins surgery
- Abstract
Background: A novel catheter design (HD Mesh ablator, Bard) combining high-density circumferential mapping and direct radiofrequency (RF) energy delivery has been developed to map and isolate the pulmonary veins (PVs)., Objective: The purpose of this study was to assess the feasibility of the Mesh catheter for PV isolation in patients with paroxysmal atrial fibrillation (AF)., Methods: Twenty consecutive patients (mean age 56.4 +/- 12.2 years; 16 men) with paroxysmal drug-refractory AF were referred for ablation. The procedure was performed in a stepwise manner: PV isolation was initially attempted with the Mesh ablator, and if that was not successful, a conventional ablation approach was then used., Results: A total of 73 PVs including seven veins with left common ostium were targeted. Successful deployment of the Mesh was achieved in all but four veins (94.5%). Using the Mesh catheter for ablation, PV isolation was achieved in 46 (63%) of the 73 PVs. The mean (RF) ablation time required to achieve complete isolation was 12.4 +/- 6.1 minutes per PV. The Mesh-only approach allowed isolation of all veins in eight (40%) patients. In combination with conventional ablation, successful PV isolation was achieved in 71 (97%) of 73 PVs. No complications attributable to the Mesh ablator occurred in this series., Conclusions: PV isolation using the Mesh catheter is feasible and may simplify the current PV isolation procedures. With the current catheter design, PV isolation could be achieved in 63% of PVs. A larger Mesh diameter with an over-the-wire design may help improve the acute success rate.
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- 2008
- Full Text
- View/download PDF
44. Results of the SCART study: selection of candidates for cardiac resynchronisation therapy.
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Peraldo C, Achilli A, Orazi S, Bianchi S, Sassara M, Laurenzi F, Cesario A, Fratianni G, Lombardo E, Valsecchi S, Denaro A, and Puglisi A
- Subjects
- Aged, Echocardiography, Doppler, Female, Heart Failure complications, Humans, Male, Prospective Studies, Stroke Volume, Ventricular Dysfunction, Left complications, Ventricular Dysfunction, Left diagnostic imaging, Cardiac Pacing, Artificial, Heart Failure therapy, Patient Selection
- Abstract
Objective: To prospectively determine whether prespecified electrocardiographic, echocardiographic and tissue Doppler imaging (TDI) selection criteria may predict a positive response to cardiac resynchronisation therapy (CRT)., Methods: In this multicentre, prospective, non-randomised study, 96 heart failure patients with New York Heart Association class III-IV symptoms, an ejection fraction of < or =35%, and at least one marker of ventricular dyssynchrony according to prespecified electrocardiographic, echocardiographic or TDI criteria were enrolled. The primary endpoint was an improvement in the clinical composite score at 6 months., Results: At enrolment, 70 patients fulfilled the electrocardiographic criterion (QRS duration > or =150 ms), 77 patients showed echocardiographic signs of dyssynchrony, and 37 patients met the TDI dyssynchrony criteria. The overall responder rate was 78/96 (81%). In particular, the primary endpoint was reached in 68 patients who fulfilled the echocardiographic criteria as compared with 10 patients who did not (88 vs. 53%, P = 0.001). The patients who met the echocardiographic criteria showed a significant greater reduction in left ventricular end-systolic diameter (P = 0.029) and a higher improvement in quality of life (P = 0.017) than patients who did not. Neither electrocardiographic nor TDI criteria seemed to predict a positive response to CRT., Conclusions: In our patient population, mechanical indexes of dyssynchrony as assessed by echocardiography appeared to identify CRT responders. Although TDI is useful for evaluating ventricular dyssynchrony after CRT, the prespecified TDI inclusion criteria adopted in this investigation did not increase the number of CRT responders.
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- 2007
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- View/download PDF
45. Endomyocardial biopsy guided by electroanatomic voltage mapping in arrhythmogenic right ventricular cardiomyopathy: a case report.
- Author
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Avella A, Pappalardo A, d'Amati G, Dello Russo A, Laurenzi F, Mancini M, Re F, Zachara E, Zecchi P, and Tondo C
- Subjects
- Adult, Cardiomyopathies complications, Humans, Male, Tachycardia, Ventricular diagnosis, Tachycardia, Ventricular etiology, Ventricular Dysfunction, Right complications, Biopsy, Needle methods, Body Surface Potential Mapping methods, Cardiomyopathies pathology, Myocardium pathology, Tachycardia, Ventricular pathology, Ventricular Dysfunction, Right pathology
- Abstract
A positive endomyocardial biopsy (EMB) is a major diagnostic criterion for arrhythmogenic right ventricular cardiomyopathy (ARVC). Nevertheless, its sensitivity is low due to the focal nature of the disease. Moreover, myocardial samples are usually taken from the uncommonly involved interventricular septum to minimize the risk of perforation. In this report, we describe a novel bioptical approach for ARVC diagnosis guided by the identification of right ventricle (RV) affected regions by means of electroanatomical voltage mapping.
- Published
- 2007
- Full Text
- View/download PDF
46. Pulmonary vein vestibule ablation for the control of atrial fibrillation in patients with impaired left ventricular function.
- Author
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Tondo C, Mantica M, Russo G, Avella A, De Luca L, Pappalardo A, Fagundes RL, Picchio E, Laurenzi F, Piazza V, and Bisceglia I
- Subjects
- Feasibility Studies, Female, Humans, Male, Middle Aged, Treatment Outcome, Atrial Fibrillation complications, Atrial Fibrillation surgery, Catheter Ablation methods, Pulmonary Veins surgery, Ventricular Dysfunction, Left etiology, Ventricular Dysfunction, Left prevention & control
- Abstract
Introduction: Congestive heart failure (CHF) and atrial fibrillation (AF) are frequently linked, and when associated produce additive deleterious effects. In this prospective study, the effects of catheter ablation for AF in patients with impaired left ventricular (LV) function are presented., Methods: Baseline data and clinical outcome have been prospectively collected in 105 consecutive patients who underwent pulmonary vein ablation for the control of AF. We evaluated 40 patients affected by LV dysfunction with ejection fraction (EF)<40% and compared them to the remaining 65 patients with normal ventricular function in terms of changes in LV function, maintenance of sinus rhythm, and quality of life during follow-up., Results: After a mean follow-up of 14+/-2 months, 87% of patients with impaired LV function and 92% of patients with normal ventricular function were in sinus rhythm, with or without antiarrhythmic therapy (P=NS). A significant improvement in LVEF and fractional shortening was documented in patients with CHF (33+/-2% vs 47+/-3%, and 19+/-4% vs 30+/-3%, P<0.01 for both comparisons). Evaluation of exercise capacity and quality of life documented better improvements in patients with CHF compared to patients without CHF., Conclusions: Catheter ablation in patients with LV dysfunction is feasible, not associated with higher procedural complications, and provides a significant improvement in LV performance, symptoms, and quality of life during follow-up.
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- 2006
- Full Text
- View/download PDF
47. [Role of electrophysiology in the prognosis and therapy of cardiomyopathies].
- Author
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Laurenzi F, Avella A, Adinolfi E, and Dini P
- Subjects
- Adrenergic beta-Antagonists therapeutic use, Amiodarone therapeutic use, Anti-Arrhythmia Agents therapeutic use, Arrhythmias, Cardiac drug therapy, Arrhythmias, Cardiac prevention & control, Arrhythmias, Cardiac therapy, Cardiomyopathies mortality, Cardiomyopathies physiopathology, Clinical Trials as Topic, Defibrillators, Implantable, Electrophysiology, Female, Follow-Up Studies, Hemodynamics, Humans, Male, Meta-Analysis as Topic, Myocardial Infarction etiology, Myocardial Infarction prevention & control, Primary Prevention, Prognosis, Randomized Controlled Trials as Topic, Risk Factors, Sotalol therapeutic use, Time Factors, Vasodilator Agents therapeutic use, Cardiomyopathies diagnosis, Cardiomyopathies therapy
- Published
- 1999
48. Pulsed-wave Doppler quantitation of aortic regurgitation associated with mitral stenosis.
- Author
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Favuzzi A, Pennestrì F, Biasucci LM, Gimigliano F, Lombardo A, Amico CM, Vigna C, Laurenzi F, and Loperfido F
- Subjects
- Adolescent, Adult, Aged, Aortic Valve Insufficiency complications, Aortic Valve Insufficiency diagnostic imaging, Aortography, Child, Female, Humans, Male, Middle Aged, Mitral Valve Stenosis complications, Mitral Valve Stenosis diagnostic imaging, Aortic Valve Insufficiency diagnosis, Echocardiography methods, Mitral Valve Stenosis diagnosis
- Published
- 1988
49. Dissection of the anterior mitral leaflet causing mitral regurgitation in aortic valve endocarditis.
- Author
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Pennestrí F, Favuzzi A, Laurenzi F, Mazzari M, and Loperfido F
- Subjects
- Adult, Echocardiography, Endocarditis, Bacterial physiopathology, Humans, Male, Mitral Valve Insufficiency physiopathology, Aortic Valve, Endocarditis, Bacterial complications, Mitral Valve Insufficiency etiology, Staphylococcal Infections
- Published
- 1987
- Full Text
- View/download PDF
50. [Usefulness of supplemental treatment with glypressin during the eradication phase of esophageal varices using endoscopic sclerotherapy].
- Author
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Palazzi A, Laurenzi F, Tiburzi C, and Ottaviani O
- Subjects
- Adult, Endoscopy, Female, Humans, Lypressin administration & dosage, Lypressin therapeutic use, Male, Middle Aged, Randomized Controlled Trials as Topic, Terlipressin, Time Factors, Esophageal and Gastric Varices therapy, Lypressin analogs & derivatives, Sclerosing Solutions therapeutic use
- Abstract
The response of 20 patients with oesophageal varices randomly assigned to treatment by endoscopic sclerotherapy with or without adjuvant Glipressina was assessed on the basis of the following parameters: mean eradication time for oesophageal varices and frequency of bleeding during that period. The preliminary results suggest that the drug may have a favourable influence on both eradication time and bleeding in sclerotherapy.
- Published
- 1989
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