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1. Men Who Have Sex with Both Men and Women in West Africa: Factors Associated with a High Behavioral Risk of Acquiring HIV from Male Partners and Transmission to Women (CohMSM ANRS 12324—Expertise France)

Author

Fiorentino, Marion, Coulibaly, Bakary, Couderc, Clotilde, Keita, Bintou Dembélé, Anoma, Camille, Dah, Elias, Mensah, Ephrem, Aka, Thomas Niamkey, Touré, Juste Rodrigue, Camara, Drissa, Kokouba, Anouwarsadat Rodolphe, Maradan, Gwenaëlle, Mora, Marion, Bourrelly, Michel, Riegel, Lucas, Rojas-Castro, Daniela, Spire, Bruno, Laurent, Christian, and Sagaon-Teyssier, Luis

Published
2024
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6. Socio-behavioral correlates of pre-exposure prophylaxis use and correct adherence in men who have sex with men in West Africa

Author

Eubanks, August, Coulibaly, Bakary, Dembélé Keita, Bintou, Anoma, Camille, Dah, Ter Tiero Elias, Mensah, Ephrem, Kaba, Sékou, Lokrou, Kpassou Julien, Ouedraogo, Faïçal Rodrigue, Badjassim, Alèda M. Fidèle, Maradan, Gwenaëlle, Bourrelly, Michel, Mora, Marion, Riegel, Lucas, Rojas Castro, Daniela, Yaya, Issifou, Spire, Bruno, Laurent, Christian, and Sagaon-Teyssier, Luis

Published
2022
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11. HIV pre-exposure prophylaxis for men who have sex with men in west Africa: a multicountry demonstration study

Author

Laurent, Christian, Yaya, Issifou, Ouedraogo, Sayouba, Granouillac, Bruno, Le Guicher, Gwenvael, Serrano, Laetitia, Peeters, Martine, Couderc, Clotilde, Spire, Bruno, Sagaon-Teyssier, Luis, Mora, Marion, Maradan, Gwenaëlle, Bourrelly, Michel, Mimi, Mohamed, Berenger, Cyril, Boyer, Sylvie, Rojas Castro, Daniela, Riegel, Lucas, Palvadeau, Paméla, Vuylsteke, Bea, De Baetselier, Irith, Reyniers, Thijs, Dembélé Keita, Bintou, Diallo, Fodié, Coulibaly, Alou, Maïga, Alassane Kader, Camara, Drissa, Diarra, Mahamadou, Ouologuem, Aly, Sangaré, Naboh, Keita, Abdoul Aziz, Cissé, Oumar, Traoré, Fodé, Ouary, Bréhima Abdrahamane, Kanta, Ibrahima, Anoma, Camille, Malan, Jean-Baptiste, Kotchi, Rachelle, Aka, Niamkey Thomas, Lokrou, Kpassou Julien, Coulibaly, Noufo Hamed, Koffi, Ekissi Jean Armel, N'guessan, Dibi Frédéric, Babo Yoro, Stéphane-Alain, Cissé, Adama, Dah, Ter Tiero Elias, Traoré, Issa, Rajaonarivelo, Camille, Ouedraogo, Fayçal Rodrique, Ouedraogo, Joseph, Coulibaly, Christian, Ouedraogo, Mamadou, Ilboudo, Ousseni, Traoré, Abdoulazziz, Comsiambo, Honoré, Mensah, Ephrem, Agboyibor, Mawuényégan Kouamivi, Attisso, Anani, Kokouba, Anouwarsadat, Badjassim, Aléda Mawuli, Agbomadji, Kouakou Kokouvi Selom, Attiogbe, Messan, Yaka, Kossi Jeff, Ekon, Agbégnigan Lorette, Bimba, Julien, Dagnra, Claver Anoumou, Tegueni, Kokou Dominique, Agboyibor, Mawuényégan K, Eubanks, August, Fayé-Ketté, Hortense, Koné, Amadou, Diandé, Souba, Dagnra, Claver A, and Dah, Ter Tiero E

Published
2021
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17. Revealing Alzheimer’s disease genes spectrum in the whole-genome by machine learning

Author

Xiaoyan Huang, Hankui Liu, Xinming Li, Liping Guan, Jiankang Li, Laurent Christian Asker M. Tellier, Huanming Yang, Jian Wang, and Jianguo Zhang

Subjects
Alzheimer’s disease, Gene, Machine learning, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Background Alzheimer’s disease (AD) is an important, progressive neurodegenerative disease, with a complex genetic architecture. A key goal of biomedical research is to seek out disease risk genes, and to elucidate the function of these risk genes in the development of disease. For this purpose, expanding the AD-associated gene set is necessary. In past research, the prediction methods for AD related genes has been limited in their exploration of the target genome regions. We here present a genome-wide method for AD candidate genes predictions. Methods We present a machine learning approach (SVM), based upon integrating gene expression data with human brain-specific gene network data, to discover the full spectrum of AD genes across the whole genome. Results We classified AD candidate genes with an accuracy and the area under the receiver operating characteristic (ROC) curve of 84.56% and 94%. Our approach provides a supplement for the spectrum of AD-associated genes extracted from more than 20,000 genes in a genome wide scale. Conclusions In this study, we have elucidated the whole-genome spectrum of AD, using a machine learning approach. Through this method, we expect for the candidate gene catalogue to provide a more comprehensive annotation of AD for researchers.

Published
2018
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21. Strategies to improve PrEP uptake among West African men who have sex with men: a multi-country qualitative study

Author

Reyniers, Thijs, primary, Babo, Stéphane Alain Yoro, additional, Ouedraogo, Mamadou, additional, Kanta, Ibrahima, additional, Ekon Agbégnigan, Laurette, additional, Rojas, Daniela, additional, Eubanks, August, additional, Anoma, Camille, additional, Dah, Ter Tiero Elias, additional, Mensah, Ephrem, additional, Dembélé Keita, Bintou, additional, Spire, Bruno, additional, Vuylsteke, Bea, additional, and Laurent, Christian, additional

Published
2023
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24. Frequent chlamydia and gonorrhoea but very infrequent syphilis among men who have sex with men using HIV pre-exposure prophylaxis in West Africa

Author

Dah, Ter Tiero Elias, De Baetselier, Irith, Cuer, Benjamin, Anoma, Camille, Mensah, Ephrem, Koné, Amadou, Diandé, Souba, Dagnra, Claver Anoumou, Faye-Kette, Hortense Yaobla, Yeo, Alain, Yaya, Issifou, Spire, Bruno, Keita, Bintou Dembélé, Crucitti, Tania, Vuylsteke, Bea, and Laurent, Christian

Abstract

ObjectivesAlthough oral pre-exposure prophylaxis (PrEP) for HIV is being rolled out in West Africa, data on sexually transmitted infections (STIs) in PrEP users are scarce. We assessed the prevalence, incidence and determinants of bacterial STIs in men who have sex with men (MSM) taking PrEP in Burkina Faso, Côte d’Ivoire, Mali and Togo.MethodsA prospective cohort study among MSM initiating PrEP as part of a comprehensive HIV prevention package was conducted between 2017 and 2021 in community-based clinics in the four study countries. Molecular screening for Chlamydia trachomatis(CT) and Neisseria gonorrhoeae(NG) was performed at months 0, 6 and 12. Serological testing for syphilis was performed every 3 months over the first year of follow-up. Determinants of CT and/or NG incidence were identified using Poisson generalised linear mixed models.ResultsA total of 598 participants with a median age of 24.7 years were included. Prevalence of CT and/or NG was 24.4% (95% CI 21.0 to 28.1), 22.4% (95% CI 18.4 to 26.8) and 29.0% (95% CI 24.2 to 34.1) at months 0, 6 and 12, respectively. The prevalence of syphilis ranged from 0.2% (95% CI 0.0 to 0.9) at month 0 to 0.8% (95% CI 0.2 to 2.4) at month 12. Ninety incident CT and/or NG infections occurred during a total follow-up time of 280.6 person-years (incidence rate 32.1 per 100 person-years, 95% CI 25.8 to 39.4). Three incident syphilis infections were detected during a total follow-up time of 459.7 person-years (incidence rate 0.7 per 100 person-years, 95% CI 0.1 to 1.9). CT and/or NG incidence was associated with condomless insertive anal sex (adjusted incidence rate ratio 1.96, 95% CI 1.04 to 3.71, p=0.038).ConclusionsCT and NG were frequent but syphilis was very infrequent in MSM using HIV PrEP in West Africa. HIV programme managers should integrate STI services into PrEP programmes.

Published
2024
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25. The Perceived Added Value of Bimonthly Injectable Pre-Exposure Prophylaxis According to West African Men Who Have Sex with Men: A Focus Group Study.

Author

Reyniers, Thijs, Fiorentino, Marion, Babo, Stéphane Alain Yoro, Ouedraogo, Mamadou, Kanta, Ibrahima, Agbegnigan, Laurette Ekon, Rojas, Daniela, Anoma, Camille, Dah, Ter Tiero Elias, Mensah, Ephrem, Keita, Bintou Dembélé, Spire, Bruno, Vuylsteke, Bea, and Laurent, Christian

Subjects
INJECTIONS, FOCUS groups, GROUNDED theory, MEN, PRE-exposure prophylaxis, SEXUALLY transmitted diseases, HEALTH behavior, RESEARCH funding, MEN who have sex with men, SEXUAL excitement, CONDOMS
Abstract

Bimonthly long-acting injectable pre-exposure prophylaxis (LAI-PrEP) can become an important additional tool for HIV prevention among West African men who have sex with men (MSM). The objective was to explore the perceived added value of LAI-PrEP as an HIV prevention tool among MSM in Burkina Faso, Côte d'Ivoire, Mali, and Togo. We conducted eight focus group discussions among 62 HIV-negative MSM between April and May 2021. Participants were recruited via local community-based clinics. Data collection and analysis were guided by grounded theory and community-based participatory approaches. Participants were generally knowledgeable about HIV, and explained particular barriers for HIV prevention in their communities (e.g., denial of HIV). The added value of LAI-PrEP relative to condoms was similar to oral pre-exposure prophylaxis (PrEP) in terms of perceived advantages (e.g., improved sexual satisfaction) or disadvantages (e.g., no protection against other sexually transmitted infections). Compared with oral PrEP, LAI-PrEP was perceived to provide better protection against HIV and to be more convenient (e.g., no need to be mindful of intake and less risk for stigma). Concerns included fear of needles, doubts about efficacy, potential side effects, and difficulties for ensuring timely injections (e.g., when traveling abroad). The results demonstrate that injectable PrEP can be of particular interest to subgroups of West African MSM, although existing HIV prevention tools such as condoms and oral PrEP will remain valuable alongside of, or instead of, LAI-PrEP. Increasing awareness about HIV and tackling discrimination based on sexual orientation continue to be crucial factors to be addressed for HIV prevention. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Human Immunodeficiency Virus Seroconversion Among Men Who Have Sex With Men Who Use Event-Driven or Daily Oral Pre-Exposure Prophylaxis (CohMSM-PrEP): A Multi-Country Demonstration Study From West Africa.

Author

Laurent, Christian, Yaya, Issifou, Cuer, Benjamin, Sagaon-Teyssier, Luis, Mensah, Ephrem, Dah, Ter Tiero Elias, Coulibaly, Alou, Kouamé, Malan Jean-Baptiste, Peytavin, Gilles, Serrano, Laetitia, Eubanks, August, Traoré, Issa, Diallo, Fodié, Riegel, Lucas, Castro, Daniela Rojas, Dagnra, Claver A, Anoma, Camille, Vuylsteke, Bea, Keita, Bintou Dembélé, and Spire, Bruno

Subjects
*HIV infection epidemiology, *SOCIAL determinants of health, *CONFIDENCE intervals, *ORAL drug administration, *MULTIVARIATE analysis, *SEROCONVERSION, *REGRESSION analysis, *DISEASE incidence, *PRE-exposure prophylaxis, *DESCRIPTIVE statistics, *RESEARCH funding, *MEN who have sex with men, *SOCIODEMOGRAPHIC factors, *DATA analysis software, *HIV, *LONGITUDINAL method, *POISSON distribution
Abstract

Background Data on human immunodeficiency virus (HIV) seroconversion among men who have sex with men (MSM) using pre-exposure prophylaxis (PrEP) in West Africa are needed. This study aimed to document HIV seroconversion and associated determinants, PrEP adherence, plasma drug concentrations, and HIV drug resistance in MSM using event-driven or daily PrEP in Burkina Faso, Côte d'Ivoire, Mali, and Togo. Methods A prospective cohort study was conducted in 2017–2021 among HIV-seronegative MSM aged 18 or over who were at high risk of HIV infection. Participants could choose between event-driven and daily PrEP, switch regimens, and discontinue or restart PrEP. The determinants of HIV incidence were investigated using a multivariate mixed-effects Poisson regression analysis. Results A total of 647 participants were followed for a total time of 1229.3 person-years. Of 5371 visits, event-driven PrEP was chosen in 3873 (72.1%), and daily PrEP in 1400 (26.1%). HIV incidence was 2.4 per 100 person-years (95% confidence interval [CI] 1.5–3.6) for event-driven PrEP, and 0.6 per 100 person-years (95% CI.1–2.3) for daily PrEP (adjusted incidence rate ratio 4.40, 95% CI 1.00–19.36, P =.050). Adequate adherence was lower with event-driven than daily PrEP (44.3% vs 74.9%, P <.001). Plasma drug concentrations were undetectable in 92 (97.9%) of the 94 measures taken for 23 participants who seroconverted. Only 1 participant had resistance to PrEP drugs. Conclusions HIV seroconversions mainly occurred in participants who chose event-driven PrEP. The study's data highlighted major difficulties with adherence to this regimen. Improving adherence to event-driven PrEP constitutes a major research and public health priority in this context. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Treatment interruption in HIV‐positive patients followed up in Cameroonʼs antiretroviral treatment programme: individual and health care supply‐related factors (ANRS‐12288 EVOLCam survey)

Author

Tong, Christelle, Suzan‐Monti, Marie, Sagaon‐Teyssier, Luis, Mimi, Mohamed, Laurent, Christian, Maradan, Gwenaëlle, Mengue, Marie‐Thérèse, Spire, Bruno, Kuaban, Christopher, Vidal, Laurent, Boyer, Sylvie, Ambani, A, Ndalle, O, Momo, P, Boyer, V, March, L, Mora, M, de Sèze, M, Liégeois, F, Delaporte, E, Boyer, V, Eymard‐Duvernay, S, Chabrol, F, Kouakam, E, Ossanga, O, Essama Owona, H, Biloa, C, Mpoudi‐Ngolé, E, Fouda, P.J, Kouanfack, C, Abessolo, H, Noumssi, N, Defo, M, Meli, H, Nanga, Z, Perfura, Y, Ngo Tonye, M, Kouambo, O, Olinga, U, Soh, E, Ejangue, C, Njom Nlend, E, Simo Ndongo, A, Abeng Mbozoʼo, E, Mpoudi Ngole, M, Manga, N, Danwe, C, Ayangma, L, Taman, B, Njitoyap Ndam, E.C, Fangam Molu, B, Meli, J, Hadja, H, Lindou, J, Bob Oyono, J.M, Beke, S, Eloundou, D, Touko, G, Ze, J.J, Fokoua, M, Ngum, L, Ewolo, C, Bondze, C, Ngan Bilong, J.D, Maninzou, D.S, Nono Toche, A, Tsoungi Akoa, M, Ateba, P, Abia, S, Guterrez, A, Garcia, R, Thumerel, P, Belley Priso, E, Mapoure, Y, Malongue, A, Meledie Ndjong, A.P, Mbatchou, B, Hachu, J, Ngwane, S, Dissongo, J, Mbangue, M, Penda, Ida, Mossi, H, Tchatchoua, G, Ngongang, Yoyo, Nouboue, C, Wandji, I, Ndalle, L, Djene, J, Gomez, M.J, Mafuta, A, Mgantcha, M, Moby, E.H, Kuitcheu, M.C, Mawe, A.L, Engonwei, Ngam, Bitang, L.J, Ndam, M, Pallawo, R.B, Adamou, Issiakou, Temgoua, G, Ndjie Essaga, C, Tchimou, C, Yeffou, A, Ngo, I, Fokam, H, Nyemb, H, Njock, L.R, Omgnesseck, S, Kamto, E, Takou, B, Buffeteau, L.J.‐G, Ndoumbe, F, Noah, J.‐D., and Seyep, I

Published
2018
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31. Socio-behavioral correlates of pre-exposure prophylaxis use and correct adherence in men who have sex with men in West Africa

Author

Eubanks, August, primary, Coulibaly, Bakary, additional, Keita, Bintou Dembélé, additional, Anoma, Camille, additional, Dah, Ter Tiero Elias, additional, Mensah, Ephrem, additional, Kaba, Sékou, additional, Lokrou, Kpassou Julien, additional, Ouedraogo, Faïçal Rodrigue, additional, Badjassim, Alèda M. Fidèle, additional, Maradan, Gwenaëlle, additional, Bourrelly, Michel, additional, Mora, Marion, additional, Riegel, Lucas, additional, Castro, Daniela Rojas, additional, Yaya, Issifou, additional, Spire, Bruno, additional, Laurent, Christian, additional, and Group, Luis Sagaon-Teyssier on behalf of the CohMSM-PrEP Study, additional

Published
2022
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32. Monitoring of HIV viral load, CD4 cell count, and clinical assessment versus clinical monitoring alone for antiretroviral therapy in low-resource settings (Stratall ANRS 12110/ESTHER): a cost-effectiveness analysis

Author

Boyer, Sylvie, March, Laura, Kouanfack, Charles, Laborde-Balen, Gabrièle, Marino, Patricia, Aghokeng, Avelin Fobang, Mpoudi-Ngole, Eitel, Koulla-Shiro, Sinata, Delaporte, Eric, Carrieri, Maria Patrizia, Spire, Bruno, Laurent, Christian, and Moatti, Jean-Paul

Published
2013
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33. Prediction of HIV Drug Resistance Based on Virologic, Immunologic, Clinical, and/or Adherence Criteria in the Stratall ANRS 12110/ESTHER Trial in Cameroon

Author

Stratall ANRS 12110/ESTHER Study Group, Boullé, Charlotte, Kouanfack, Charles, Laborde-Balen, Gabrièle, Aghokeng, Avelin Fobang, Boyer, Sylvie, Carrieri, Maria Patrizia, Kazé, Serge, Mben, Jean-Marc, Dontsop, Marlise, Spire, Bruno, Peeters, Martine, Mpoudi-Ngolé, Eitel, Delaporte, Eric, and Laurent, Christian

Published
2013
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34. Plasmodium falciparum-like parasites infecting wild apes in southern Cameroon do not represent a recurrent source of human malaria

Author

Sundararaman, Sesh A., Liu, Weimin, Keele, Brandon F., Learn, Gerald H., Bittinger, Kyle, Mouacha, Fatima, Ahuka-Mundeke, Steve, Manske, Magnus, Sherrill-Mix, Scott, Li, Yingying, Malenke, Jordan A., Delaporte, Eric, Laurent, Christian, Ngole, Eitel Mpoudi, Kwiatkowski, Dominic P., Shaw, George M., Rayner, Julian C., Peeters, Martine, Sharp, Paul M., Bushman, Frederic D., and Hahn, Beatrice H.

Published
2013

38. Hepatitis B testing, treatment, and virologic suppression in HIV-infected patients in Cameroon (ANRS 12288 EVOLCAM)

Author

Liégeois, Florian, Boyer, S., Eymard-Duvernay, Sabrina, Carrieri, P., Kouanfack, C., Domyeum, J., Maradan, G., Ducos, J., Mpoudi-Ngole, E., Spire, B., Delaporte, E., Kuaban, C., Vidal, Laurent, Laurent, Christian, and EVOLCAM Study Group

Subjects
Treatment, Africa, Testing, HBV, virus diseases, HIV, lcsh:RC109-216, lcsh:Infectious and parasitic diseases
Abstract

Background Hepatitis B is a major concern in Africa, especially in HIV-infected patients. Unfortunately, access to hepatitis B virus (HBV) testing and adequate treatment remains a challenge in the continent. We investigated HBV testing, treatment, and virologic suppression in HIV-infected patients followed up as part of Cameroon’s national antiretroviral programme. Methods A cross-sectional survey was performed in adult patients receiving antiretroviral therapy (ART) in 19 hospitals in the Centre and Littoral regions in Cameroon. The proportions of patients tested for hepatitis B surface antigen (HBsAg) prior to the study were compared among all study hospitals using the Chi-square test. The association of individual and hospital-related characteristics with HBV testing and virologic suppression was assessed using multilevel logistic regression models. Results Of 1706 patients (women 74%, median age 42 years, median time on ART 3.9 years), 302 (17.7%) had been tested for HBsAg prior to the study. The proportion of HBV-tested patients ranged from 0.8 to 72.5% according to the individual hospital (p

Published
2020

40. Additional file 2 of Examining educational attainment and allostatic load in non-Hispanic Black women

Author

Williams, Brittany Marie, Laurent, Christian, Chawla, Rishab, and Moore, Justin Xavier

Abstract

Additional file 2: Supplemental Table 2. Association Between Education and High Allostatic Load Stratified by Age Groups, Presented as Prevalence Ratios (PRs) and Associated 95% Confidence Intervals (CIs), among 4,177 participants, using NHANES weighting an estimated 9,494,904 US Black Women.

Published
2022
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43. Low Levels of Antiretroviral-Resistant HIV Infection in a Routine Clinic in Cameroon That Uses the World Health Organization (WHO) Public Health Approach to Monitor Antiretroviral Treatment and Adequacy with the WHO Recommendation for Second-Line Treatment

Author

Kouanfack, Charles, Montavon, Celine, Laurent, Christian, Aghokeng, Avelin, Kenfack, Alain, Bourgeois, Anke, Koulla-Shiro, Sinata, Mpoudi-Ngole, Eitel, Peeters, Martine, and Delaporte, Eric

Published
2009
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44. Monitoring of HIV viral loads, CD4 cell counts, and clinical assessments versus clinical monitoring alone for antiretroviral therapy in rural district hospitals in Cameroon (Stratall ANRS 12110/ESTHER): a randomised non-inferiority trial

Author

Laurent, Christian, Kouanfack, Charles, Laborde-Balen, Gabrièle, Aghokeng, Avelin Fobang, Mbougua, Jules Brice Tchatchueng, Boyer, Sylvie, Carrieri, Maria Patrizia, Mben, Jean-Marc, Dontsop, Marlise, Kazé, Serge, Molinari, Nicolas, Bourgeois, Anke, Mpoudi-Ngolé, Eitel, Spire, Bruno, Koulla-Shiro, Sinata, and Delaporte, Eric

Published
2011
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46. The Performance of Immunoassays to Measure Antibodies to the Chlamydia trachomatis Antigen Pgp3 in Different Epidemiological Settings for Trachoma

Author

Gwyn, Sarah, primary, Nute, Andrew W., additional, Sata, Eshetu, additional, Tadesse, Zerihun, additional, Chernet, Ambahun, additional, Haile, Mahteme, additional, Zeru, Taye, additional, Bethea, Danaya, additional, Laurent, Christian, additional, Callahan, E. Kelly, additional, Nash, Scott D., additional, and Martin, Diana L., additional

Published
2021
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47. Loss to Follow-Up from HIV Pre-Exposure Prophylaxis Care in Men Who Have Sex with Men in West Africa.

Author

Eubanks, August, Coulibaly, Bakary, Keita, Bintou Dembélé, Anoma, Camille, Dah, Ter Tiero Elias, Mensah, Ephrem, Maradan, Gwenaëlle, Bourrelly, Michel, Mora, Marion, Riegel, Lucas, Rojas Castro, Daniela, Yaya, Issifou, Spire, Bruno, Laurent, Christian, and Sagaon-Teyssier, Luis

Subjects
HIV, PRE-exposure prophylaxis, HIV infections
Abstract

Loss to follow-up (LTFU) from HIV pre-exposure prophylaxis (PrEP) care compromises the goal of HIV elimination. We investigated the proportion of LTFU and associated risk factors among men who have sex with men (MSM) enrolled in a PrEP demonstration project in Burkina Faso, Côte d'Ivoire, Mali, and Togo. CohMSM-PrEP, a prospective cohort study, was conducted between November 2017 and June 2021 in community-based clinics. MSM aged 18 years or older at substantial risk of HIV infection received a comprehensive prevention package, including PrEP and peer education. LTFU was defined as not returning to the clinic for six months. Associated risk factors were investigated using a time-varying Cox's model. Of 647 participants followed up for a median time of 15 months, 372 were LTFU (57.5%). LTFU was associated with younger age (adjusted hazard ratio [95% Confidence Interval]; 1.50 [1.17–1.94]), unemployment (1.33 [1.03–1.71]), depression (1.63 [1.12–2.38]), and perceiving no HIV risk with stable male partners (1.61 [1.23–2.10]). Contacting peer educators outside of scheduled visits was protective (0.74 [0.56–0.97]). Our findings show that LTFU from PrEP care in West African MSM is a major challenge to achieving HIV elimination, but that the involvement of peer educators in PrEP delivery helps to limit LTFU by providing users with adequate support. [ABSTRACT FROM AUTHOR]

Published
2022
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48. Mycoplasma genitalium and Antimicrobial Resistance Among a Cohort of West African Men Who Have Sex With Men Using Preexposure Prophylaxis (CohMSM-PrEP ANRS 12369-Expertise France Study).

Author

Baetselier, Irith De, Vuylsteke, Bea, Cuylaerts, Vicky, Cuer, Benjamin, Yaya, Issifou, Mensah, Ephrem, Dah, Elias, Anoma, Camille, Koné, Amadou, Diandé, Souba, Dagnra, Anoumou, Fayé-Ketté, Hortense, Yeo, Alain, Smet, Hilde, Bossche, Dorien Van den, Keita, Bintou Dembélé, Spire, Bruno, Laurent, Christian, Crucitti, Tania, and Group, CohMSM-PrEP Study

Subjects
DRUG resistance in microorganisms, AFRICANS, MYCOPLASMA, HIV, RIBOSOMAL RNA
Abstract

Background Antimicrobial resistance to macrolides and fluoroquinolones in Mycoplasma genitalium (MG) among men who have sex with men (MSM) is worryingly high in high-resource countries. Data in Africa are lacking. We aimed to assess the burden of MG including the presence of resistance-associated mutations (RAMs) in MG among MSM using human immunodeficiency virus preexposure prophylaxis in Burkina Faso, Côte d'Ivoire, Mali, and Togo. Methods MSM were included in a prospective cohort study (2017–2021). Molecular detection of MG in urine, anorectal, and pharyngeal samples was performed at baseline and after 6 and 12 months. Detection of RAMs to macrolides and fluoroquinolones was performed by sequencing the 23S ribosomal RNA, parC , and gyrA genes. A sample was found to be possibly resistant to fluoroquinolones if alterations were found in ParC position 83/87. Results Of 598 participants, 173 (28.9%) were positive at least once for MG and global point-prevalence was 19.4%. Interestingly, 238 of 250 (95.2%) infections were asymptomatic and 72 of 138 MG infections with follow-up data (52.2%) cleared during the study. Only 1 macrolide RAM was found (0.6%). Prevalence of fluoroquinolones RAMs was 11.3% overall, ranging from 2.4% in Burkina Faso to 17.5% in Mali. Conclusions Although MG was highly prevalent in these MSM, macrolide resistance was almost nonexistent. Nevertheless, >10% of the samples were possibly resistant to fluoroquinolones. Heterogeneity in the prevalence of fluoroquinolone RAMs between countries may be explained by different antimicrobial consumption in humans and animals. [ABSTRACT FROM AUTHOR]

Published
2022
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49. Combined sexual behavioral profiles in HIV-seronegative men who have sex with men in West Africa (CohMSM ANRS 12324-Expertise France)

Author

Coulaud, P. J., Sagaon Teyssier, Luis, Mrenda, B. M., Maradan, G., Mora, M., Bourrelly, M., Keita, B. D., Keita, A. A., Anoma, C., Yoro, S. A. B., Dah, T. T. E., Coulibaly, C., Mensah, E., Agbomadji, S., Bernier, A., Couderc, C., Laurent, Christian, Spire, B., Granouillac, Bruno (collab.), Izard, Suzanne (collab.), Laurent, Christian (collab.), March, Laura (collab.), Peeters, Martine (collab.), and CohMSM ANRS 12324 Study Group

Subjects
Sexual behavior, Identity, HIV risk, West Africa, virus diseases, Sexual orientation, MSM
Abstract

Understanding the dynamics of HIV infection in men who have sex with men (MSM) can help improve efficiency in existing prevention strategies. We aimed to identify and describe the sexual behaviors of MSM most at risk of HIV infection in West Africa. HIV-negative MSM were provided a quarterly preventive follow-up package in the community-based cohort CohMSM. They completed face-to-face sociobehavioral questionnaires every 6 months. This sub-study on 520 participants used a baseline, 6-, 12- and 18-month data cluster analysis to categorize two profiles (high risk [HRE] and moderate risk [MRE] of exposure to HIV) based on three risky sexual practices over the previous 6 months. HRE-MSM (61%) were more engaged in receptive practices, had a higher proportion of inconsistent condom use during anal sex, and reported more sexual partners than MRE-MSM (39%). The proportion of HIV seroconversions observed during the first 18 months of follow-up using sexual behavioral profiles (92% are HRE-MSM) was higher than using the three risky sexual practices separately. Factors associated with the HRE-MSM profile were being younger (18-21 years), reporting stigma, and having had no female partner while being attracted only to men. Our findings suggest that in order to identify MSM most at risk of HIV infection, several risky sexual practices need to be evaluated in a combined approach. Prevention programs should pay particular attention to younger MSM, and implement activities addressing questions of MSM identity and stigma in order to reduce the dynamic of HIV infection in Western African MSM.

Published
2020

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