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3 results on '"Laurence Fauconnier"'

1. Interleukin-7 regulates adipose tissue mass and insulin sensitivity in high-fat diet-fed mice through lymphocyte-dependent and independent mechanisms.

Author

Stéphanie Lucas, Solenne Taront, Christophe Magnan, Laurence Fauconnier, Myriam Delacre, Laurence Macia, Anne Delanoye, Claudie Verwaerde, Corentin Spriet, Pasquine Saule, Gautier Goormachtigh, Laurent Héliot, Alain Ktorza, Jamileh Movassat, Renata Polakowska, Claude Auriault, Odile Poulain-Godefroy, James Di Santo, Philippe Froguel, and Isabelle Wolowczuk

Subjects
Medicine, Science
Abstract

Although interleukin (IL)-7 is mostly known as a key regulator of lymphocyte homeostasis, we recently demonstrated that it also contributes to body weight regulation through a hypothalamic control. Previous studies have shown that IL-7 is produced by the human obese white adipose tissue (WAT) yet its potential role on WAT development and function in obesity remains unknown. Here, we first show that transgenic mice overexpressing IL-7 have reduced adipose tissue mass associated with glucose and insulin resistance. Moreover, in the high-fat diet (HFD)-induced obesity model, a single administration of IL-7 to C57BL/6 mice is sufficient to prevent HFD-induced WAT mass increase and glucose intolerance. This metabolic protective effect is accompanied by a significant decreased inflammation in WAT. In lymphocyte-deficient HFD-fed SCID mice, IL-7 injection still protects from WAT mass gain. However, IL-7-triggered resistance against WAT inflammation and glucose intolerance is lost in SCID mice. These results suggest that IL-7 regulates adipose tissue mass through a lymphocyte-independent mechanism while its protective role on glucose homeostasis would be relayed by immune cells that participate to WAT inflammation. Our observations establish a key role for IL-7 in the complex mechanisms by which immune mediators modulate metabolic functions.

Published
2012
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2. Un jour de pluie

Author

Laurence Fauconnier and Laurence Fauconnier

Abstract

'Un jour de pluie'est un témoignage bouleversant qui pourrait transformer votre vision de la vie. Laure y partage sa perception de l'existence, une vie qu'elle endure plus qu'elle ne la vit. À travers ses réflexions et ses expériences, elle finit par réaliser que la vie vaut la peine d'être pleinement vécue. Malheureusement, cette prise de conscience arrive trop tard. Déterminée à transmettre cette précieuse leçon à sa fille, elle se heurte à l'impitoyable fuite du temps, et son message semble se perdre. « Rien n'allait, rien ne va, et rien n'ira jamais », se dit-elle.À PROPOS DE L'AUTRICELaurence Fauconnier trouve refuge dans l'écriture, un sanctuaire où elle libère les pensées et les inquiétudes qui emplissent son esprit. Que ce soit sur un post-it, une feuille de papier ou une page Word, elle partage ses réflexions avec le monde, chaque texte surpassant le précédent. Son écriture est une quête d'allégement de l'âme et une invitation à la découverte.

Published
2024

3. Interleukin-7 Regulates Adipose Tissue Mass and Insulin Sensitivity in High-Fat Diet-Fed Mice through Lymphocyte-Dependent and Independent Mechanisms

Author

Laurence Fauconnier, Laurent Héliot, Corentin Spriet, Christophe Magnan, Odile Poulain-Godefroy, Gautier Goormachtigh, Claude Auriault, Renata Polakowska, Solenne Taront, Isabelle Wolowczuk, Stéphanie Lucas, Philippe Froguel, Laurence Macia, Anne Delanoye, Alain Ktorza, Pasquine Saule, Claudie Verwaerde, James P. Di Santo, Jamileh Movassat, Myriam Delacre, Médecine cellulaire et moléculaire (MCM), Université de Lille, Sciences et Technologies-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS), Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 (GI3M), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physiopathologie de la nutrition (LPN), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Immunopathologie cellulaire des maladies infectieuses (ICMI), Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche Interdisciplinaire [Villeneuve d'Ascq] (IRI), Centre National de la Recherche Scientifique (CNRS)-Université de Lille, Droit et Santé-Université de Lille, Sciences et Technologies, Centre National de la Recherche Scientifique (CNRS), Université Paris Diderot - Paris 7 (UPD7), Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U1172 Inserm - U837 (JPArc), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Lille Nord de France (COMUE)-Université de Lille, Immunité Innée, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), The work was supported by the Pasteur Institute in Lille, the Institut Fédératif de Recherche 142 and the Centre National de la Recherche Scientifique. S. L. was supported by a post-doctoral grant from the French Région Nord/Pas-de-Calais., Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 (EGENODIA (GI3M)), Université de Lille, Sciences et Technologies-Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 (JPArc), Université Lille Nord de France (COMUE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER], and Mécanismes de la Tumorigénèse et Thérapies Ciblées - UMR 8161 [M3T]

Subjects
Male, Anatomy and Physiology, B Cells, Mouse, medicine.medical_treatment, Adipose tissue, lcsh:Medicine, White adipose tissue, Mice, SCID, Monocytes, Mice, 0302 clinical medicine, Endocrinology, Lymphocyte homeostasis, Immune Physiology, Glucose homeostasis, Lymphocytes, lcsh:Science, 0303 health sciences, Multidisciplinary, Interleukin, food and beverages, Organ Size, Animal Models, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Cytokines, Medicine, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, lipids (amino acids, peptides, and proteins), hormones, hormone substitutes, and hormone antagonists, Research Article, medicine.medical_specialty, Adipose Tissue, White, Immune Cells, Immunology, Blood sugar, Endocrine System, Immunopathology, Biology, Diet, High-Fat, Protective Agents, 03 medical and health sciences, Insulin resistance, Model Organisms, Internal medicine, Glucose Intolerance, medicine, Animals, Humans, Obesity, 030304 developmental biology, Nutrition, Inflammation, Diabetic Endocrinology, Receptors, Interleukin-7, Endocrine Physiology, Insulin, Interleukin-7, lcsh:R, Immunity, nutritional and metabolic diseases, Feeding Behavior, Molecular Development, Diabetes Mellitus Type 2, medicine.disease, Mice, Inbred C57BL, Immune System, Metabolic Disorders, lcsh:Q, Clinical Immunology, Insulin Resistance, Stromal Cells, Physiological Processes, Energy Metabolism, 030217 neurology & neurosurgery, Developmental Biology
Abstract

International audience; Although interleukin (IL)-7 is mostly known as a key regulator of lymphocyte homeostasis, we recently demonstrated that it also contributes to body weight regulation through a hypothalamic control. Previous studies have shown that IL-7 is produced by the human obese white adipose tissue (WAT) yet its potential role on WAT development and function in obesity remains unknown. Here, we first show that transgenic mice overexpressing IL-7 have reduced adipose tissue mass associated with glucose and insulin resistance. Moreover, in the high-fat diet (HFD)-induced obesity model, a single administration of IL-7 to C57BL/6 mice is sufficient to prevent HFD-induced WAT mass increase and glucose intolerance. This metabolic protective effect is accompanied by a significant decreased inflammation in WAT. In lymphocyte-deficient HFD-fed SCID mice, IL-7 injection still protects from WAT mass gain. However, IL-7-triggered resistance against WAT inflammation and glucose intolerance is lost in SCID mice. These results suggest that IL-7 regulates adipose tissue mass through a lymphocyte-independent mechanism while its protective role on glucose homeostasis would be relayed by immune cells that participate to WAT inflammation. Our observations establish a key role for IL-7 in the complex mechanisms by which immune mediators modulate metabolic functions.

Published
2012
Full Text
View/download PDF

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