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Extralabel drug use is the use of a Food and Drug Administration (FDA)-approved drug in a manner different from what is stipulated on the approved label. Compounding is the process of preparing a medication in a manner not indicated on the label to create a formulation specifically tailored to the needs of an individual patient. Extralabel drug use and compounding are vital aspects of safe and effective drug delivery to patients in exotic animal practice. There are few FDA-approved drugs for exotic animal species, and many approved drugs for other species are not available in suitable formulations for use in exotic animals.

The ferret was domesticated in Europe some 2000 years ago and has since been used to control rodent populations, hunt rabbits, and as a biomedical research model. Currently, ferrets are popular pets in many parts of the world. Ferrets are strict carnivores and their anatomy and physiology are similar to other small carnivores, although there are important differences in their reproductive physiology.

Cranial kinesis of the avian beak is complex; particularly in birds with prokinetic beak movement, such as psittacine birds. A number of diseases can result in damage to the bony and soft tissue structures of the beak and can lead to secondary pathology, such as beak deviation, abnormal rhamphothecal growth and wear, and opportunistic infections. A solid understanding of species-specific anatomic variations is essential before attempting rhamphothecal restoration or surgical repair. Many diseases of the oral cavity can appear similar on initial clinical evaluation and therefore warrant appropriate diagnostic testing.

Proventricular infection with the anamorphic, ascomycetous yeast Macrorhabdus ornithogaster and disease associated with infection (macrorhabdiosis) have been widely reported in budgerigars ( Melopsittacus undulatus). Proventricular adenocarcinoma has also been previously reported in this species. In a retrospective archival search of clinical cases submitted to a zoo animal and exotic pet pathology service between 1998 and 2013, a total of 28 128 avian submissions were identified, which included 1006 budgerigars kept in zoos or aviaries or as pets. Of these budgerigars, 177 were identified histologically as infected with M. orthithogaster at the time of necropsy. Histologic examination of tissues from budgerigars infected with M. orthithogaster identified an apparent continuum in the development of proventricular isthmus lesions associated with M. ornithogaster that included inflammation, mucosal hyperplasia, glandular dysplasia, and adenocarcinoma. Proventricular adenocarcinoma was identified histologically in 21 budgerigars. Budgerigars with proventricular adenocarcinoma were significantly more likely to have macrorhabdiosis than budgerigars without proventricular adenocarcinoma. Based on odds ratios for archival data, budgerigars were 41 times (95% confidence interval [CI], 33–52) more likely to have macrorhabdiosis than other avian species and 19 times (95% CI, 11–33) more likely to have proventricular adenocarcinoma than other birds. Budgerigars were 323 times (95% CI, 42–2490) more likely to be affected by both diseases simultaneously compared with other avian species. These findings suggest that macrorhabdiosis may be an associated factor for proventricular adenocarcinoma, although the explanation for this statistically significant correlation remains unknown and further investigation is warranted.

Many pufferfish possess tetrodotoxin (TTX). Unaware of this fact, the owner of a 3-mo-old pet Cuvier's dwarf caiman (Paleosuchus palpebrosus) fed the caiman a green spotted pufferfish (Tetraodon nigroviridis), acquired from a local discount department store. The caiman was nonresponsive within an hour of consumption of the fish. The caiman was presented for veterinary evaluation but died despite intensive medical care. High-performance liquid chromatography and a competitive inhibition enzyme immunoassay were used to determine whether the pufferfish was tetrodotoxic and whether the deceased caiman had TTX in its system. Skin and liver of the pufferfish harbored high concentrations of TTX, and the caiman had TTX in the blood, liver, and kidney. The clinical signs and presence of TTX in the caiman suggest that the caiman succumbed to tetrodotoxicosis. The implication is that lethally poisonous species are available commercially and pose a danger to other pets and possibly small children.

The domestic ferret, Mustela putorius furo, is a popular companion animal and is used in biomedical research. When compared with other companion mammals, primary bacterial and parasitic infections are less common in domestic ferrets. In countries such as the United States, pet ferrets are generally kept indoors, and the risk for exposure to primary bacterial and parasitic infectious agents is low. Companion, breeding, and working ferrets are commonly kept outdoors in other parts of the world, placing them at comparatively greater risk for exposure to infectious diseases. This article discusses clinical signs, diagnosis, and treatment of bacterial and parasitic diseases of ferrets.

Psittacine birds are challenging to medicate, because they can deliver a painful bite and can learn to resist drug administration. Some drug delivery systems require restraint or sedation for placement, which may not be tolerated by critically ill birds. In this article, drug-delivery strategies will be discussed regarding psittacine species, including the benefits and risks of each method as well as practical guidance based on the experience of this and other authors.

Exotic small mammal species can pose interesting and unique challenges for drug delivery. Many species are inherently difficult to medicate, such as African pygmy hedgehogs ( Atelerix albiventris ). Options for drug administration may be limited by small patient size. This article will review commonly used routes of delivery for drug administration and discuss the advantages, limitations, and practical tips of each strategy.

Psittacines pose interesting and challenging dilemmas for restraint, sample collection, and treatment. Critically ill birds often cannot tolerate prolonged handling or sedation. Although most procedures used in canine and feline patients are easily adapted to the psittacine, anatomic and physiologic differences obligate practitioners to familiarize themselves with the unique features of these patients. Many procedures performed in psittacines are unique to birds owing to these differences. This article reviews procedures commonly used to handle and restrain the psittacine, to collect diagnostic samples, and to deliver therapeutic agents.

Objective—To describe morbidity, function, outcome, and owner satisfaction associated with limb amputation in domestic rabbits. Design—Retrospective case series. Animals—34 client-owned domestic rabbits. Procedures—Medical records of domestic rabbits undergoing limb amputation for any cause between 2000 and 2009 were reviewed. The Kaplan-Meier method was used to estimate survival rate and median survival time, and variables were analyzed for relationship to risk of morbidity resulting in euthanasia and to outcome (survival vs nonsurvival [death or euthanasia]). Owners were interviewed to determine satisfaction with outcome of the procedure. Results—28 rabbits underwent pelvic limb amputation, and 6 underwent thoracic limb amputation. At the last follow-up, 18 rabbits were dead, 9 were alive, and 7 were lost to follow-up. Median overall survival time was 720 days (range, 4 to 3,250 days). Acute and delayed or chronic complications were observed in 22 of 34 and 19 of 32 rabbits, respectively, most commonly difficulty ambulating, hygiene issues, and pododermatitis (cutaneous ulcers at the hock). Six rabbits were euthanized because of complications at a median of 104 days (range, 4 to 399 days) after surgery. Risk of morbidity resulting in euthanasia increased with heavier body weight and concurrent disease affecting ambulation at the time of amputation. Weight, age, and pododermatitis at the time of amputation were significantly negatively associated with survival time. Thirty-one (91%) owners were satisfied with the outcome. Conclusions and Clinical Relevance—Although limb amputation was tolerated by most rabbits and most owners were satisfied, complications resulted in death in 6 of 34 (18%) rabbits, and 19 of 32 (59%) developed chronic complications. Amputation in heavy rabbits or those with concurrent pododermatitis, musculoskeletal disease, or neurologic disease should be considered carefully. Because of the small sample size and retrospective nature of this study, results should be interpreted as exploratory and hypothesis generating.

Chlamydiosis is an important cause of morbidity and mortality in cockatiels (Nymphicus hollandicus); however, little published information is available regarding effective treatment options for this species. This preliminary study was conducted to determine if adequate plasma concentrations of doxycycline, the antibiotic of choice for treating chlamydiosis in pet birds, could be achieved in cockatiels by using different methods of administration. Doxycycline hyclate was administered to 5 groups comprising 3 to 6 birds each by intramuscular injection (100 mg/kg IM every 10 days for 5 injections) or by mixing with drinking water (0.28 or 0.83 mg/ml), seeds (500 mg/kg wet weight), or mash (1000 mg/kg). Three additional groups of birds received unmedicated food and water and served as controls. Plasma doxycycline concentrations were measured periodically during the 45-day trial. Birds given doxycycline by intramuscular injection had variable, localized tissue reactions and a mean trial plasma concent...

Postnatal changes in wing morphology, flight ability, muscle morphology, and histochemistry were investigated in the little brown bat, Myotis lucifugus. The pectoralis major, acromiodeltoideus, and quadriceps femoris muscles were examined using stains for myofibrillar ATPase, succinate dehydrogenase (SDH), and mitochondrial α-glycerophosphate dehydrogenase (α-GPDH) enzyme reactions. Bats first exhibited spontaneous, drop-evoked flapping behavior at 10 days, short horizontal flight at 17 days, and sustained flight at 24 days of age. Wing loading decreased and aspect ratio increased during postnatal development, each reaching adult range before the onset of sustained flight. Histochemically, fibers from the three muscles were undifferentiated at birth and had lower oxidative and glycolytic capacities compared to other age groups. Cross-sectional areas of fibers from the pectoralis and acromiodeltoideus muscles increased significantly at an age when dropevoked flapping behavior was first observed, suggesting that the neuromuscular mechanism controlling flapping did not develop until this time. Throughout the postnatal growth period, pectoralis and acromiodeltoideus muscle mass and fiber cross-sectional area increased significantly. By day 17 the pectoralis muscle had become differentiated in glycolytic capacity, as indicated by the mosaic staining pattern for α-GPDH. By contrast, the quadriceps fibers were relatively large at birth and slowly increased in size during the postnatal period. Fiber differentiation was evident at the time young bats began to fly, as indicated by a mosaic pattern of staining for myosin ATPase. These results indicate that flight muscles (pectoralis and acromiodeltoideus) are less well developed at birth and undergo rapid development just before the onset of flight. By contrast the quadriceps femoris muscle, which is required for postural control, is more developed at birth than the flight muscles and grows more slowly during subsequent development.

An adult Moluccan cockatoo (Cacatua moluccensis) was diagnosed with a cystadenocarcinoma in the right axillary region that was treated symptomatically with surgical debulking and periodic drainage. The bird eventually died and a necropsy was performed. The neoplasm extended through the humerus, and small neoplastic foci were seen within the ipsilateral lung parenchyma. Rare groupings of microvilli were observed lining intercellular canalicular lumens on electron microscopy within the axillary tumor. These findings suggest a respiratory neoplasm, although the tissue of origin remained undetermined.